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BackgroundClozapine belongs to atypical antipsychotic drugs that has shown significant efficacy in treating schizophrenia. However， clozapine can induce arrhythmias in patients. Currently， there is a lack of systematic research on the types and incidence of clozapine-induced arrhythmias.ObjectiveTo explore the types and incidence of arrhythmias in patients with schizophrenia induced by clozapine through Meta-analysis， so as to provide references for clinical treatment.MethodsOn October 31， 2022， a search was conducted through PubMed， Embase， Cochrane Library and China National Knowledge Infrastructure （CNKI） to collect relevant literature on clozapine-induced arrhythmia in patients with schizophrenia. Joanna Briggs Institute （JBI） was used to evaluate the quality of the included literature. Meta-analysis was conducted using Review Manager 5.4.ResultsA total of 12 studies were included， involving 42 490 schizophrenia patients taking clozapine. The incidence of arrhythmias caused by clozapine was 23% （95% CI： 0.16~0.29）. Among them， the incidence of tachycardia was 25% （95% CI： 0.15~0.35）， atrial arrhythmia was 6% （95% CI： -0.02~0.14）， ventricular arrhythmia was 7% （95% CI： -0.02~0.16）， conduction block was 2% （95% CI： 0~0.04）， QTc prolongation was 4% （95% CI： -0.04~0.12） and T-wave changes was 23% （95% CI： 0.16~0.30）.ConclusionSchizophrenia patients taking clozapine may increase their risk of developing arrhythmia， with tachycardia being the most prevalent. ［Funded by Graduate Innovation Fund of Kunming Medical University （number， 2023S302）］

Abstract We explore the impact of initial state soft gluon radiations on the azimuthal angle asymmetries in photo-production of hard di-jet via coherent diffraction in ultraperipheral heavy ion collisions, as well as in electron-proton (ep) and electron-nucleus (eA) collisions. The primary production mechanism is identified as the diffractive production of two hard jets, accompanied by a collinear gluon emission along the beam direction. In contrast, the diffractive exclusive di-jet production, where the initial state radiation is absent, is suppressed due to color transparency. Our analysis shows that azimuthal asymmetries, traditionally attributed to final state gluon emissions, are reduced by the presence of initial state radiations. The sensitivity of azimuthal asymmetries to both initial and final state radiations suggests that they could provide novel insights into the mechanisms of di-jet production in diffractive processes.

Abstract We compute the gluon beam function for jet-veto resummation to next-to-next-to-leading order (NNLO) in the strong-coupling expansion. Our calculation is based on an automated framework that was previously used for the computation of the respective quark beam function, and which we significantly extended for the present calculation. In particular, the perturbative matching kernels are directly calculated in momentum space, without the need to perform an additional Mellin transform. We present results for both gluon and quark-initiated processes, which we cross-checked with an independent semi-analytical method that exploits the similarity of the beam functions to the more familiar case of transverse-momentum resummation. Our computation is relevant for jet-veto resummations at NNLL′ accuracy.

Background In patients with untreated CD20-positive diffuse large B-cell lymphoma (DLBCL), a phase 3 trial was carried out to evaluate the efficacy and safety of zuberitamab plus CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone; Hi-CHOP) versus rituximab plus CHOP (R-CHOP) treatment regimens.Methods In a 2:1 ratio, eligible patients were assigned randomly to receive treatment of six cycles of either 375 mg/m2 zuberitamab or rituximab together with conventional CHOP chemotherapy. The objective response rate (ORR) at C6D50 served as the primary endpoint, and a non-inferiority margin of 10% was established. The secondary endpoints included the complete response (CR) rate at C6D50, duration of response (DOR), progression-free survival (PFS) and event-free survival (EFS) judged by blinded-independent review committee (BIRC), overall survival (OS) and safety outcomes.Results Of the 487 randomized patients, 423 patients including 287 in the Hi-CHOP and 136 in the R-CHOP groups completed the C6D50 assessment. For the full analysis set (FAS) and per-protocol set (PPS), BIRC-assessed ORR at C6D50 for the Hi-CHOP and R-CHOP groups were 83.5% versus 81.4% and 95.3% versus 93.7%, respectively. The non-inferiority was confirmed as the lower limit of the two-sided 95% CI for the intergroup differences of −5.2% and −3.3%; both were >−10% in the FAS and PPS. The BIRC-assessed CR rate of Hi-CHOP was significantly higher in PPS (85.7% vs 77.3%, p=0.038), but comparable in FAS (75.2% vs 67.9%, p=0.092). After a median follow-up of 29.6 months, patients in the Hi-CHOP group had a slight advantage with regard to the DOR (HR 0.74, p=0.173), PFS (HR 0.67, p=0.057), EFS (HR 0.90, p=0.517) and OS (HR 0.60, p=0.059). Patients with the germinal-center B cell-like subtype who received Hi-CHOP exhibited statistically significant improvements in ORR (p=0.034) and CR rate (p=0.038) at C6D50, EFS (p=0.046) and OS (p=0.014). Treatment-emergent adverse event occurrence rates were comparable across groups (all p>0.05). Infusion-related responses occurred more often in the Hi-CHOP group (32.1% vs 19.9%, p=0.006), all of grade 1–3 severity.Conclusions Zuberitamab (375 mg/m2) plus CHOP was non-inferior to R-CHOP regarding ORR but exhibited a higher CR rate and was well tolerated in CD20-positive, previously untreated Chinese patients with DLBCL.Trial registration number Chinese Clinical Trial Registry, ChiCTR2000040602, retrospectively registered.

Abstract In this study, we explore the azimuthal angle decorrelation of lepton-jet pairs in e-p and e-A collisions as a means for precision measurements of the three-dimensional structure of bound and free nucleons. Utilizing soft-collinear effective theory, we perform the first-ever resummation of this process in e-p collisions at NNLL accuracy using a recoil-free jet axis. Our results are validated against Pythia simulations. In e-A collisions, we address the complex interplay between three characteristic length scales: the medium length L, the mean free path of the energetic parton in the medium λ, and the hadronization length L h . We demonstrate that in the thin-dilute limit, where L ≪ L h and L ~ λ, this process can serve as a robust probe of the three-dimensional structure for bound nucleons. We conclude by offering predictions for future experiments at the Electron-Ion Collider within this limit.

Abstract We study the azimuthal angle dependence of the energy-energy correlators $$\langle \mathcal{E}\left({\widehat{n}}_{1}\right)\mathcal{E}\left({\widehat{n}}_{2}\right)\rangle $$ in the back-to-back region for e + e − annihilation and deep inelastic scattering (DIS) processes with general polarization of the proton beam. We demonstrate that the polarization information of the beam and the underlying partons from the hard scattering is propagated into the azimuthal angle dependence of the energy-energy correlators. In the process, we define the Collins-type EEC jet functions and introduce a new EEC observable using the lab-frame angles in the DIS process. Furthermore, we extend our formalism to explore the two-point energy correlation between hadrons with different quantum numbers $${\mathbb{S}}_{i}$$ in the back-to-back limit $$\langle {\mathcal{E}}_{{\mathbb{S}}_{1}}\left({\widehat{n}}_{1}\right){\mathcal{E}}_{{\mathbb{S}}_{2}}\left({\widehat{n}}_{2}\right)\rangle $$ . We find that in the Operator Product Expansion (OPE) region the nonperturbative information is entirely encapsulated by a single number. Using our formalism, we present several phenomenological studies that showcase how energy correlators can be used to probe transverse momentum dependent structures.

Background: To investigate the predictive value of specific immunoglobulin E (sIgE), interleukin-6 (IL-6) and regulatory T cells (Treg) on the risk of postoperative recurrence in patients with eosinophilic Chronic rhinosinusitis with nasal polyps (EcRswNP). Methods: A total of 198 patients with EcRswNP collected to our Hospital from January 2019 to December 2021 were selected as the research subjects. All patients underwent functional endoscopic sinus surgery. The patients were selected to recurrence group (RG, n = 48) and nonrecurrence group (NRG, n = 150) on the basis of the recurrence after 1 year of follow-up. The related factors of postoperative recurrence of EcRswNP were analyzed. The ROC was used to analyze the dangerous of sIgE, IL-6 and Treg in predicting postoperative recurrence of EcRswNP patients. Results: The proportion of asthma patients, nasal congestion VAS score, and peripheral blood Eos% content in the RG exceeded that in the NRG, and the Organization Neu % and peripheral blood Neu% levels were less than those in the NRGp (P all < 0.05). The serum sIgE and serum IL6 in the RG were higher than those in the NRG, while the level of peripheral blood Treg was lower than that in the NRG (P < 0.05). Logistic regression analysis showed that high levels of serum sIgE, serum IL-6 and low Treg levels were risk factors for postoperative recurrence (P < 0.05). ROC showed that the AUC of peripheral blood sIgE level, IL-6 and Treg levels alone in predicting the dangerous of postoperative recurrence in patients with EcRswNP were 0.786, 0.707 and 0.636, respectively (all P < 0.05); The AUC of combined prediction of peripheral blood sIgE, IL-6 and Treg levels for postoperative recurrence dangerous in patients with EcRswNP was 0.973, indicating that the efficacy of jointed prediction was exceed than that of single prediction (P < 0.05). Conclusions: The high levels of sIgE, IL6 and low Treg levels in patients with EcRswNP before operation will increase the risk of postoperative recurrence, which is a risk factor affecting postoperative recurrence, and the three indicators have good predictive value for predicting postoperative recurrence in patients with EcRswNP, and the combination of the three indicators has better value in predicting postoperative recurrence.

Abstract HLX01 (HanliKang®) is a rituximab biosimilar that showed bioequivalence to reference rituximab in untreated CD20-positive diffuse large B-cell lymphoma (DLBCL) in the phase 3 HLX01-NHL03 study. Here, we report the 5-year follow-up results from the open-label extension part. Patients were randomised to either rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or HLX01 plus CHOP (H-CHOP) every 21 days for up to six cycles. The primary efficacy endpoint was overall survival (OS), and secondary efficacy endpoint was progression-free survival (PFS). Of the 407 patients enrolled in HLX01-NHL03, 316 patients (H-CHOP = 157; R-CHOP = 159) were included in the 5-year follow-up for a median duration of 65.1 (range, 2.2–76.5) months. 96.5% of the patients had an International Prognostic Index (IPI) of 1 or 2, and 17.7% had bone marrow involvement. The 5-year OS rates were 81.0% (95% CI: 74.9–87.5%) and 75.4% (95% CI: 68.9–82.6%)( HR: 0.75, 95% CI 0.47–1.20; p = 0.23) while 5-year PFS rates were 77.7% (95% CI: 71.4–84.6%) and 73.0% (95% CI: 66.3–80.3%) (HR: 0.84, 95% CI 0.54–1.30; p = 0.43) in the H-CHOP and R-CHOP groups, respectively. Treatment outcomes did not differ between groups regardless of IPI score and were consistent with the primary analysis. H-CHOP and R-CHOP provided no significant difference in 5-year OS or PFS in previously untreated patients with low or low-intermediate risk DLBCL.

Corn is abundant in carbohydrate, protein, carbohydrates and other nutrients. However, because of its large embryo, it is easy to be infected by microorganisms and insects, which leads to the deterioration of corn quality. Therefore, the quality preservation and storage of corn is a challenge. So it is necessary to clarify the rule and change of corn storage quality. Corns with initial water content of 13.04%, 14.03% and 14.99% were taken as reasearch objects in this paper. During storage between 70% relative humidity and 20 ℃ (quasi-low temperature environment) , the changes laws of quality indexes such as bulk density, fatty acid value, germination rate, mold activity and microstructure of corn grain were studied emphatically. Otherwise changes of storage quality of corn at 70% relative humidity and 25 ℃ (room temperature environment) were compared. Therefore it can provide reference for safe storage of high-quality corn. The results demonstrated that the germination rate, fatty acid value and bulk density of corn under 20 ℃ were slower than those under 25 ℃. And they were in the suitable storage range in accordance with the national standard. The number of fungal spores increased sharply with the prolonged storage time. Meanwhile it showed significant correlation with the initial moisture content of corn. In other words, the number of fungal spores for corn under 14.99%w.b was stored for 120 d, and the safe storage periods of corn under 13.04%w.b, 14.03%w.b and 14.99%w.b were 180 d, 180 d and 100 d, respectively. The microstructure of corn kernel changed gradually during storage. It means the appearance changed from smooth and tidy to concave and convex folds. Furthermore, the arrangement of starch granules changed from tight structure to sparse and disordered structure. The main factors of corn quality and microstructure change were corn initial water content and storage time, during storage at quasi-low temperature environment. So the change laws of corn storage quality with different water content were explored, so as to provide new research perspective for maize post-harvest to reduce loss and guarantee qualtiy.

Abstract We present a systematic formalism based on a factorization theorem in soft-collinear effective theory to describe non-global observables at hadron colliders, such as gap-between-jets cross sections. The cross sections are factorized into convolutions of hard functions, capturing the dependence on the partonic center-of-mass energy s ̂ $$ \sqrt{\hat{s}} $$ , and low-energy matrix elements, which are sensitive to the low scale Q 0 ≪ s ̂ $$ \sqrt{\hat{s}} $$ characteristic of the veto imposed on energetic emissions into the gap between the jets. The scale evolution of both objects is governed by a renormalization-group equation, which we derive at one-loop order. By solving the evolution equation for the hard functions for arbitrary 2 → M jet processes in the leading logarithmic approximation, we accomplish for the first time the all-order resummation of the so-called “super-leading logarithms” discovered in 2006, thereby solving an old problem of quantum field theory. We study the numerical size of the corresponding effects for different partonic scattering processes and explain why they are sizable for pp → 2 jets processes, but suppressed in H/Z and H/Z + jet production. The super-leading logarithms are given by an alternating series, whose individual terms can be much larger than the resummed result, even in very high orders of the loop expansion. Resummation is therefore essential to control these effects. We find that the asymptotic fall-off of the resummed series is much weaker than for standard Sudakov form factors.

As artificial intelligence (AI) permeates almost all aspects of our lives, university students need to acquire relevant knowledge, skills, and attitudes to adapt to the challenges it poses. This study reports the development and validation of a scale called the Artificial Intelligence Learning Intention Scale (AILIS). AILIS was designed to measure the different factors that shape university students’ behavioral intentions to learn about AI and their AI learning. We recruited 907 Chinese university students who answered the survey. The scale is comprised of 9 factors that are categorized into various dimensions pertaining to epistemic capacity (AI basic knowledge, programming efficacy, designing AI for social good), facilitating environments (actual use of AI systems, subjective norms, access to support and technology), psychological attitudes (resilience, optimism, personal relevance), and focal outcomes (behavioral intention to learn AI, actual learning of AI). Reliability analyses and confirmatory factor analyses indicated that the scale has acceptable reliability and construct validity. Structural equational modeling results demonstrated the critical role played by epistemic capacity, facilitating environments, and psychological attitudes in promoting students’ behavioral intentions and actual learning of AI. Overall, the findings revealed that university students express a strong intention to learn about AI, and this behavioral intention is positively associated with actual learning. The study contextualizes the theory of planned behavior for university AI education, provides guidelines on the design of AI curriculum courses, and proposes a possible tool to evaluate university AI curriculum.

Summary: Alzheimer’s disease (AD) is the most common neurodegenerative disease often associated with olfactory dysfunction. Aβ is a typical AD hall marker, but Aβ-induced molecular alterations in olfactory memory remain unclear. In this study, we used a 5xFAD mouse model to investigate Aβ-induced olfactory changes. Results showed that 4-month-old 5xFAD have olfactory memory impairment accompanied by piriform cortex neuron activity decline and no sound or working memory impairment. In addition, synapse and glia functional alteration is consistent across different ages at the proteomic level. Microglia and astrocyte specific proteins showed strong interactions in the conserved co-expression network module. Moreover, this interaction declines only in mild cognitive impairment patients in human postmortem brain proteomic data. This suggests that astrocytes-microglia interaction may play a leading role in the early stage of Aβ-induced olfactory memory impairment, and the decreasing of their synergy may accelerate the neurodegeneration.

Abstract We apply the joint threshold and transverse momentum dependent (TMD) factorization theorem to introduce new threshold-TMD distribution functions, including threshold-TMD parton distribution functions (PDFs) and fragmentation functions (FFs). We apply Soft-Collinear Effective Theory and renormalization group methods to carry out QCD evolution for both threshold-TMD PDFs and FFs. We show the universality of threshold-TMD functions among three standard processes, i.e. the Drell-Yan production in pp collisions, semi-inclusive deep-inelastic scattering and back-to-back two hadron production in e + e − collisions. In the end, we present the numerical predictions for different threshold-TMD functions and also transverse momentum distributions at pp, ep, and e + e − collisions.

Objective: The effects of freezing method and storage temperature on the quality of large yellow croaker during storage were investigated. Methods: Fresh large yellow croaker fillets were frozen with dry ice and air freezing (-40 ℃) to the central temperature of -18 ℃, and then stored at -40 ℃ and -18 ℃, respectively. Physical and chemical indexes such as freezing curve, ice crystal morphology, pH value, volatile base nitrogen, K value, Ca2+-ATPase activity, total sulfhydryl group, carbonyl group, protein degradation and texture characteristics of large yellow croaks were determined after freezing and during freezing storage. Results: The time of dry ice freezing through the maximum ice crystal formation zone was 40 min, which is 1/6 of that of air freezing at -40 ℃. The initial ice crystal cross-section area and equivalent diameter of dry ice frozen fish samples were (96.12±1.61) μm2 and (11.06±1.43) μm, respectively, which is significantly lower than that of air frozen fish samples. Conclusion: The effect of freezing temperature on fish myofibrillator protein was greater than that of freezing temperature, and a lower freezing temperature can result in a lower degradation degree of fish myofibrillator protein. Storage at -40 ℃ after dry ice freezing is beneficial to maintain freshness and quality stability of large yellow croaker.

Abstract We study the azimuthal angular decorrelations of dijet production in both proton-proton (pp) and proton-nucleus (pA) collisions. By utilizing soft-collinear effective theory, we establish the factorization and resummation formalism at the next-to-leading logarithmic accuracy for the azimuthal angular decorrelations in the back-to-back limit in pp collisions. We propose an approach where the nuclear modifications to dijet production in pA collisions are accounted for in the nuclear modified transverse momentum dependent parton distribution functions (nTMDPDFs), which contain both collinear and transverse dynamics. This approach naturally generalizes the well-established formalism related to the nuclear modified collinear parton distribution functions (nPDFs). We demonstrate strong consistency between our methodology and the CMS measurements in both pp and pA collisions, and make predictions for dijet production in the forward rapidity region in pA collisions at LHC kinematics and for mid-rapidity kinematics at sPHENIX. Throughout this paper, we focus on the application of this formalism to a simultaneous fit to both collinear and transverse momentum dependent contributions to the transverse momentum dependent distributions.

Objective To contrastive analyze the safety of percutaneous dilated tracheotomy under direct vision (PDTUDV) compared with standard percutaneous dilated tracheotomy (PDT) in severe neurosurgical patients. Methods A total of 420 severe neurosurgical patients were included from January 2012 to December 2021, with 163 cases received percutaneous dilated tracheotomy under direct vision and 257 cases received standard percutaneous dilated tracheotomy. Operation time, as well as complication rates of severe intraoperative bleeding, low oxygen, cardiac arrest, and subcutaneous emphysema, pneumothorax, mediastinal emphysema, tracheal catheter entering the outer airway space, posterior tracheal wall injury and incision infection were recorded. Results Percutaneous dilated tracheostomy under direct vision operation time was longer than standard percutaneous dilated tracheostomy [(21.74 ± 2.90) min vs. (12.74 ± 1.96) min; t = 38.050, P = 0.000]. The complication rate in the standard percutaneous dilation tracheostomy group was 7.78% (20/257), 5 cases (1.95%) with severe intraoperative bleeding, 4 cases (1.56%) with subcutaneous emphysema, one case (0.39%) with pneumothorax, 2 cases (0.78%) with mediastinal emphysema, 2 cases (0.78%) with tracheal catheter entering the outer airway space, 3 cases (1.17%) with posterior tracheal wall injury, and 3 cases (1.17%) with incision infection; the complication rate of percutaneous dilated tracheostomy under direct vision group was 4.29% (7/163), one case (0.61%) with severe intraoperative hemorrhage, 2 cases (1.23%) with subcutaneous emphysema, 2 cases (1.23%) with mediastinal emphysema, one case (0.61%) with tracheal catheter entering the outer airway space, one case (0.61%) with incision infection, there was no significant difference in the complication rate between 2 groups (χ2 = 2.017, P = 0.156). Conclusions Percutaneous dilated tracheostomy under direct vision can be effectively used in severe neurosurgical patients with standard percutaneous dilation tracheostomy uesd limited. It is easy to operate, minimally invasive, and does not increase the complication rate.

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is capable of large‐scale transmission and has caused the coronavirus disease 2019 (COVID‐19) pandemic. Patients with COVID‐19 may experience persistent long‐term health issues, known as long COVID. Both acute SARS‐CoV‐2 infection and long COVID have resulted in persistent negative impacts on global public health. The effective application and development of blood‐derived products are important strategies to combat the serious damage caused by COVID‐19. Since the emergence of COVID‐19, various blood‐derived products that target or do not target SARS‐CoV‐2 have been investigated for therapeutic applications. SARS‐CoV‐2‐targeting blood‐derived products, including COVID‐19 convalescent plasma, COVID‐19 hyperimmune globulin, and recombinant anti‐SARS‐CoV‐2 neutralizing immunoglobulin G, are virus‐targeting and can provide immediate control of viral infection in the short term. Non‐SARS‐CoV‐2‐targeting blood‐derived products, including intravenous immunoglobulin and human serum albumin exhibit anti‐inflammatory, immunomodulatory, antioxidant, and anticoagulatory properties. Rational use of these products can be beneficial to patients with SARS‐CoV‐2 infection or long COVID. With evidence accumulated since the pandemic began, we here summarize the progress of blood‐derived product therapies for COVID‐19, discuss the effective methods and scenarios regarding these therapies, and provide guidance and suggestions for clinical treatment.

Neutrophils are resident immune cells in the lung, which can release decondensed chromatin containing neutrophil elastases, myeloperoxidases, citrullinated histones and cytoskeletal proteins upon stimulation, namely neutrophil extracellular traps(NETs). NETs play an anti-infective role in lung diseases. But excessive NETs release potentially leads to cause lung tissue injury, enhances inflammatory response and promotes tumor metastasis. These results of research provide some new ideas for the development of potential drugs.

ObjectiveTo evaluate the reproductive toxicity of water extract of flower of Dendrobium devonianum Paxt.MethodsAccording to the reproductive toxicity evaluation from National Standard of the People’s Republic of China ‘Reproductive Toxicity Study’（GB 15193.15—2015）， 240 nine-week-old SD rats （120 male and 120 female） were randomly grouped by body weight at a dose of 0.0， 2.5， 5.0 and 15.0 g/kg∙BW， respectively. SD rats were administrated by gavage. The detection included the body weight and and ingestion variations from 1st to10th week， reproductive organ weights and coefficients of F0 rats； the sperm parameters of F0 male rats， and estrous cycles， fertility index （conception and pregnancy rate）， teratogenicity index （uterus weight， implantation number， corpus luteum number， living embryo number， resorption embryo number/rate and dead embryo number/rate） of F0 female rats； the survival rate and body weight variation during lactation period， anogenital distance， average litter size， sex ratio of F1 rats； the puberty onset （testis descending， foreskin separation， vaginal opening）， body weight variation， reproductive organ weights and coefficients， and sperm parameters of F1 rats； the pathological examination on harvested organs of F0 and F1 rats including testis， epididymis， uterus and ovaries.ResultsCompared with control group， no significant difference in reproductive toxicity to F0 and F1 rats was observed in three dose groups （P>0.05）. And no significant change was observed via histopathological examination.ConclusionIn this reproductive test， the no observed adverse effect level （NOAEL） of water extract of the flower of Dendrobium devonianum Paxt.is 15.0 g/kg∙BW.

Abstract The azimuthal angular decorrelation of a vector boson and jet is sensitive to QCD radiation, and can be used to probe the quark-gluon plasma in heavy-ion collisions. By using a recoil-free jet definition, the sensitivity to contamination from soft radiation on the measurement is reduced, and the complication of non-global logarithms is eliminated from our theoretical calculation. Specifically we will consider the p T n $$ {p}_T^n $$ recombination scheme, as well as the n → ∞ limit, known as the winner-take-all scheme. These jet definitions also significantly simplify the calculation for a track-based measurement, which is preferred due to its superior angular resolution. We present a detailed discussion of the factorization in Soft-Collinear Effective Theory, revealing why the transverse momentum q → T $$ {\overrightarrow{q}}_T $$ is more complicated than the azimuthal angle. We show that potential glauber contributions do not spoil our factorization formalism, at least up to and including order α s 3 $$ {\alpha}_s^3 $$ . The resummation is carried out using the renormalization group, and all necessary ingredients are collected or calculated. We conclude with a detailed phenomenological study, finding an enhanced matching correction for high jet p T due to the electroweak collinear enhancement of a boson emission off di-jets. We also compare with the Pythia event generator, finding that our observable is very robust to hadronization and the underlying event.

Abstract We study the azimuthal angular decorrelation of the dijet production via photon fusion in ultra-peripheral heavy ion collisions. The impact parameter dependent cross section of quark-antiquark pairs production is derived using the equivalent photon approximation, and the contribution from final-state QCD radiations to the azimuthal angular distribution are calculated within Soft-Collinear Effective Theory. We carry out the QCD resummation of large logarithms of the azimuthal angle as well as the jet radius at next-to-leading logarithmic accuracy. In the end we present the normalized differential cross section for azimuthal decorrelation of the dijet pair and find that our results are consistent with the measurements reported by the ATLAS collaboration.

Abstract The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated variants. Here, we report that the inactivated COVID-19 vaccine can stimulate immunity in recovered patients to maintain high levels of anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, and high neutralizing activity against the prototype, Delta, and Omicron strains was observed. Nevertheless, the antibody response decreased over time, and the Omicron variant exhibited more pronounced resistance to neutralization than the prototype and Delta strains. Moreover, the intensity of the SARS-CoV-2-specific CD4+ T cell response was also increased in recovered patients who received COVID-19 vaccines. Overall, the repeated antigen exposure provided by inactivated COVID-19 vaccination greatly boosted both the potency and breadth of the humoral and cellular immune responses against SARS-CoV-2, effectively protecting recovered individuals from reinfection by circulating SARS-CoV-2 and its variants.

The subgrade mud pumping of heavy-haul railway is widespread and harmful, which seriously affects the stability of tracks and the safety of train operation. The properties of railway subgrade soil, such as the particle gradation, the void ratio, have a significant impact on the characteristics of subgrade mud pumping under train load. In this study, a series of remolded samples consisting of silty clay and different content of Kaolin was subjected to mud pumping tests with a self-developed test model. The influence of varying particle gradations (Kaolin content) and initial dry densities (void ratio) on axial strain, excess pore water pressure, and fine particles migration under dynamic load were analyzed. The results show that with the increase in Kaolin content and initial dry density, the axial strain and the excess pore water pressure of the samples, the average migration height of fine particles, and the degree of subgrade mud pumping all decrease. We also find that the excess pore water pressure gradient is the leading factor driving the migration of fine particles in subgrade soil, and the interlayer has a promoting effect on the occurrence of subgrade mud pumping.

Functionalized carbon quantum dots (CQDs) show great potential for application in the field of food safety. CQDs have attracted widespread attention in this regard due to the wide range of sources of raw materials for their synthesis, and their good biocompatibility and stable fluorescence. This paper analyses the properties of CQDs and compares with those of conventional semiconductor quantum dots (SCQDs). It analyses the similarities and differences between hydrothermal carbonization, pyrolysis and microwave-assisted synthesis of CQDs, and reviews the principles and methods of functionalization of CQDs through surface modification and doping. Finally, it discusses the applications of functionalized CQDs in food safety, such as detection and sensing, bio-inhibition and photocatalytic degradation, and the mechanisms of detection.

The fundamental extraction principle, production process, and instrument of the subcritical fluid (including water) technology in terms of the aquatic products materials were introduced in this review, and the academic progress of SFE technology in extracting and separating nutritional components from the aquatic products within the recent 10 years were summarized, in terms of proteins/peptides, lipids and polysaccharides from aquatic products. The advantages of different processing factors for the extraction of specific components were summarized, and the future development direction of SFE equipment and technology in the deep processing of aquatic products was prospected.

Objectives This network meta-analysis aimed to compare the efficacy and safety of intravenous (IV) hydralazine, oral nifedipine, and IV labetalol with different dosage regimens in the treatment of severe hypertension during pregnancy. Methods A comprehensive literature search was performed on PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov for randomized controlled trials (RCTs) exploring the effects of hydralazine, nifedipine, and labetalol in the treatment of severe hypertension during pregnancy. Results A total of 21 RCTs with 2183 patients comparing 7 regimens (oral nifedipine 50,60,90 mg; hydralazine 15,25 mg; and labetalol 220,300 mg) were identified. Compared with IV labetalol 300 mg, nifedipine 50,60, and 90 mg significantly improved the successful treatment rate of severe hypertension during pregnancy, nifedipine 50 and 90 mg and IV hydralazine 25 mg required significantly fewer doses to achieve target blood pressure (BP), and nifedipine 50 mg took significantly shorter time to achieve target BP. Subgroup analysis showed that only nifedipine 50 mg tablets, not capsules, required a significantly shorter time and fewer doses to achieve target BP than IV labetalol 300 mg. Moreover, nifedipine 60,90 mg showed superior effectiveness than IV hydralazine 15,25 mg in the successful treatment rate of severe hypertension during pregnancy. SUCRA analysis suggested that nifedipine 50,60,90 mg as the better regimens with the lower rates of overall ADR and neonatal complications. Conclusion These findings demonstrated the superiority of oral nifedipine 50,60,90 mg, especially oral nifedipine 50 mg tablets, in the treatment of severe hypertension during pregnancy than IV labetalol 300 mg, while oral nifedipine 60,90 mg also showed superiority in the successful treatment rate of severe hypertension during pregnancy than IV hydralazine 15,25 mg. However, the limitations of the underlying data indicate that future large-scale and rigorous RCTs are needed to confirm such findings.

Purpose: Prostate cancer (PCa) poses a great threat to humans. The study aimed to evaluate the potential of TQB3720 in promoting ferroptosis to suppress prostate cancer, providing a theoretical basis for PCa therapy.Methods: PCa cells and nude mice models were divided into TQB3720, enzalutamide (ENZ), and control groups. Sulforhodamine B assay, colony formation assessment, organoids culture system, and the CCK8 assay were used for detecting proliferation. Western blot assay was processed to detect the expression of androgen receptor (AR), ferroptosis, and apoptosis-related genes. Flow cytometry was applied to measure the intracellular ROS levels. ELISA was performed to determine the cellular oxidized glutathione (GSSG) and malondialdehyde (MDA) levels. RT-qPCR was conducted to detect the mRNA expression of genes in AR signaling. BODIPYTM™ 581/591 was processed for detection of intracellular lipid peroxidation levels. The interaction of AR with other translational factor complex proteins was explored using Co-immunoprecipitation (Co-IP), and the chromatin immunoprecipitation (ChIP) assay was performed to detect the binding of AR-involved translational complex to downstream genes promoter. Luciferase reporter assay was conducted to examine the translation activity of GPX4 promoter, and immunohistochemistry (IHC) was conducted to analyze the levels of c-MYC, Ki-67 and AR in TQB3720-treated cancer tissues.Results: Here, we found TQB3720 inhibits the growth of prostate cancer in vitro and in vivo. TQB3720 treatment induced intracellular levels of GSSG and MDA significantly, by which hints AR antagonist caused ferroptosis-related cell death. Moreover, molecular evidence shown TQB3720 regulates downstream of AR signaling by binding AR resulting in inhibition of AR entry into the nucleus. Additional, we also proved that TQB3720 abrogates the interaction between AR and SP1 and leads to decrease GPX4 transcription.Conclusion: TQB3720 promotes ferroptosis in prostate cancer cells by reducing the AR/SP1 transcriptional complex binding to GPX4 promoter. As a result, it is suggested to be a potential drug for clinic prostate cancer treatment.

Background and objectives The adverse effects of plasma donation on the body has lowered the odds of donation. The aim of this study was to investigate the prevalence of abnormal serum calcium and total serum protein related to plasma donation, identify the influencing factors, and come up with suggestions to make plasma donation safer. Methods Donors from 10 plasmapheresis centers in five provinces of China participated in this study. Serum samples were collected before donation. Serum calcium was measured by arsenazo III colorimetry, and the biuret method was used for total serum protein assay. An automatic biochemical analyzer was used to conduct serum calcium and total serum protein tests. Results The mean serum calcium was 2.3 ± 0.15 mmol/L and total serum protein was 67.75 ± 6.02 g/L. The proportions of plasma donors whose serum calcium and total serum protein were lower than normal were 20.55% (815/3,966) and 27.99% (1,111/3,969), respectively. There were significant differences in mean serum calcium and total serum protein of plasma donors with different plasma donation frequencies, gender, age, regions, and body mass index (BMI), (all p

Abstract We study all the possible spin asymmetries that can arise in back-to-back electron-jet production, ep → e + jet + X, as well as the associated jet fragmentation process, ep → e+jet(h)+X, in electron-proton collisions. We derive the factorization formalism for these spin asymmetries and perform the corresponding phenomenology for the kinematics relevant to the future electron ion collider. In the case of unpolarized electron-proton scattering, we also give predictions for azimuthal asymmetries for the HERA experiment. This demonstrates that electron-jet production is an outstanding process for probing unpolarized and polarized transverse momentum dependent parton distribution functions and fragmentation functions.

Background: The aim of this study was to investigate the effects of intravenous immunoglobulins (IVIg) in the immunotherapy of in vitro fertilization and embryo transfer (IVF-ET) patients and to provide insights into the treatment strategy for implantation failure. Methods: A retrospective observational study of 245 patients with unexplained repeated implantation failure in our hospital from 2016 to 2021 was conducted. Among these patients, 124 were administered IVIg according to their preferences during the preparation of implantation, while the others were not given IVIg as a control group. The basic characteristics of the patients in the two groups did not show any significant differences. Biochemical pregnancy rate, clinical pregnancy rate, and live birth rate were compared in the two groups, and also in the IVIg group and the control group, by age (

COVID-19 pandemic is a global health risk, but our understanding on the induced durable immunity remains scarce. Here the authors assess antibody responses in 869 convalescent COVID-19 patients to find that specific antibody titers reduce with time, and the RBD-IgG positive rate exceed 70% at 12 month post diagnosis, with male and older patients showing stronger responses.

Abstract Using Soft-Collinear Effective Theory, we develop the transverse-momentum-dependent factorization formalism for heavy flavor dijet production in polarized-proton-electron collisions. We consider heavy flavor mass corrections in the collinear-soft and jet functions, as well as the associated evolution equations. Using this formalism, we generate a prediction for the gluon Sivers asymmetry for charm and bottom dijet production at the future Electron-Ion Collider. Furthermore, we compare theoretical predictions with and without the inclusion of finite quark masses. We find that the heavy flavor mass effects can give sizable corrections to the predicted asymmetry.

Mapping is a fundamental application of remote sensing images, and the accurate evaluation of remote sensing image information extraction using artificial intelligence is critical. However, the existing evaluation method, based on Intersection over Union (IoU), is limited in evaluating the extracted information’s boundary accuracy. It is insufficient for determining mapping accuracy. Furthermore, traditional remote sensing mapping methods struggle to match the inflection points encountered in artificial intelligence contour extraction. In order to address these issues, we propose the mean inflection point distance (MPD) as a new segmentation evaluation method. MPD can accurately calculate error values and solve the problem of multiple inflection points, which traditional remote sensing mapping cannot match. We tested three algorithms on the Vaihingen dataset: Mask R-CNN, Swin Transformer, and PointRend. The results show that MPD is highly sensitive to mapping accuracy, can calculate error values accurately, and is applicable for different scales of mapping accuracy while maintaining high visual consistency. This study helps to assess the accuracy of automatic mapping using remote sensing artificial intelligence.

Abstract We study the single spin asymmetry in the back-to-back dijet production in transversely polarized proton-proton collisions. Such an asymmetry is generated by the Sivers functions in the incoming polarized proton. We propose a QCD formalism in terms of the transverse momentum dependent parton distribution functions, which allow us to resum the large logarithms that arise in the perturbative calculations. We make predictions for the Sivers asymmetry of hadronic dijet production at the kinematic region that is relevant to the experiment at the Relativistic Heavy Ion Collider (RHIC). We further compute the spin asymmetries in the selected positive and negative jet charge bins, to separate the contributions from u- and d-quark Sivers functions. We find that both the sign and size of our numerical results are roughly consistent with the preliminary results from the STAR collaboration at the RHIC.

Abstract We derive the transverse momentum dependent (TMD) factorization and resummation formula of the unpolarized transverse momentum distribution (j T ) for the single hadron production with the thrust axis in an electron-positron collision. Two different kinematic regions are considered, including small transverse momentum limit j T « Q, and joint transverse momentum and threshold limit j T « Q(1 − z h ) « Q, where Q and z h are the hard scattering energy and the observed hadron momentum fraction. Using effective theory methods, we resum logarithms ln(Q/j T ) and ln(1 − z h ) to all orders. In the end, we present the differential cross sections and Gaussian widths calculated for the inclusive charged pion production and find that our results are consistent with the measurements reported by the Belle collaboration.

Abstract Coronavirus disease 2019 (COVID‐19) remains a global public health threat. Hence, more effective and specific antivirals are urgently needed. Here, COVID‐19 hyperimmune globulin (COVID‐HIG), a passive immunotherapy, is prepared from the plasma of healthy donors vaccinated with BBIBP‐CorV (Sinopharm COVID‐19 vaccine). COVID‐HIG shows high‐affinity binding to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike (S) protein, the receptor‐binding domain (RBD), the N‐terminal domain of the S protein, and the nucleocapsid protein; and blocks RBD binding to human angiotensin‐converting enzyme 2 (hACE2). Pseudotyped and authentic virus‐based assays show that COVID‐HIG displays broad‐spectrum neutralization effects on a wide variety of SARS‐CoV‐2 variants, including D614G, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Kappa (B.1.617.1), Delta (B.1.617.2), and Omicron (B.1.1.529) in vitro. However, a significant reduction in the neutralization titer is detected against Beta, Delta, and Omicron variants. Additionally, assessments of the prophylactic and treatment efficacy of COVID‐HIG in an Adv5‐hACE2‐transduced IFNAR−/− mouse model of SARS‐CoV‐2 infection show significantly reduced weight loss, lung viral loads, and lung pathological injury. Moreover, COVID‐HIG exhibits neutralization potency similar to that of anti‐SARS‐CoV‐2 hyperimmune globulin from pooled convalescent plasma. Overall, the results demonstrate the potential of COVID‐HIG against SARS‐CoV‐2 infection and provide reference for subsequent clinical trials.

Recycling is the most effective way to dispose of waste polymer materials. It can not only reduce the harm of polymer materials to the natural environment, but also achieve the purpose of saving cost and turning waste into treasure. A self-made melt differential electrospinning device was used to recover the degraded polypropylene (PP) non-woven fabric as a raw material, and the special powder for recycling and degrading PP non-woven fabric after acid treatment and adding different plasticizers with a mass fraction of 10%. A blend of materials of sodium stearate, acetyl tributyl citrate (ATBC), and dioctyl adipate (DOA) was spun, and a nanofiber membrane was prepared at 300 ℃. The optimum degradation time of PP nonwoven fabric spinning and the effect of adding different plasticizers on the morphology, oil absorption performance and reusability of PP-degraded non-woven fabric nanofibers were investigated. Studies have shown that the addition of plasticizer ATBC works best. When the spinning voltage is 40 kV, the spinning distance is 70 mm, the spinning temperature is 300 ℃, and the ATBC mass fraction is 10%, the fiber diameter is as fine as 1.13 μm. The fiber membrane oil absorption ratio is 115.4 g/g, and the oil retention ratio is 70.3 g/g, which are 4 times and 3 times that of the initially commercially available PP nonwoven fabric, and has good reusability.

Precipitation and evolution behavior of phases in Inconel 625 superalloy were reviewed, and the various types of phases in the alloy were emphatically introduced, including the γ' phase, γ″ phase, δ phase, Ni2(Cr,Mo) phase, three types of MC,M6C,M23C6 carbides and Laves phase. The precipitation and evolution behavior of phases in different forming processes, heat treatment and high temperature creep were elucidated. Further, the effects of different types of phases on the properties of the alloys were discussed. The main factors causing cracks during rapid forming and welding in Inconel 625 alloy were pointed out and it was proposed that an important development direction in the future is how to improve the thermal strength and thermal fatigue properties of the Inconel 625 alloy by selecting and controlling the phase precipitation.

Abstract Rituximab in combination with chemotherapy has shown efficacy in patients with diffuse large B-cell lymphoma (DLBCL) for more than 15 years. HLX01 was developed as the rituximab biosimilar following a stepwise approach to demonstrate biosimilarity in analytical, pre-clinical, and clinical investigations to reference rituximab. With demonstrated pharmacokinetic similarity, a phase 3 multi-center, randomized, parallel, double-blind study (HLX01-NHL03) was subsequently conducted to compare efficacy and safety between HLX01 plus cyclophosphamide, doxorubicin, vincristine, and prednisone (H-CHOP) and reference rituximab plus CHOP (R-CHOP) in a total of 407 treatment-naïve, CD20-positive DLBCL patients aged 18–80 years. The primary efficacy endpoint was best overall response rate (ORR) within six cycles of treatment in the per-protocol set (PPS). Secondary endpoints included 1-year efficacy outcomes, safety, and immunogenicity profile. The results showed difference in ORRs [H-CHOP 94.1%; R-CHOP 92.8%] between two treatment groups was 1.4% (95% confidence interval [CI], − 3.59 to 6.32, p = 0.608) which falls within the pre-defined equivalence margin of ± 12%. The safety profile was comparable between the treatment groups, with a similar overall incidence of treatment-emergent adverse events (H-CHOP 99.5%, R-CHOP 99.0%, p = 1.000) and serious adverse events (H-CHOP 34.0%, R-CHOP 32.5%, p = 0.752). This study established bioequivalence in efficacy and safety between HLX01 and reference rituximab. The trial was registered at http://www.chinadrugtrials.org.cn on 26 August 2015 [#CTR20150583].

This paper presents a GPS-derived slant water vapor technique for cloud monitoring in Singapore. The normalized slant wet delay (SWD) and slant water vapor (SWV) are introduced. The suitability of the normalized SWV over SWV for cloud monitoring is demonstrated, as it is not very sensitive to the satellite elevation angle. For better illustration and representation of the spatial distribution of the normalized SWV, the skyplot is discretized into different cells based on the azimuth and elevation angles to produce the spatial plot. The spatial plots are analyzed for cloud monitoring and compared alongside the sky images. The results show that the spatial plots of normalized SWV are generally consistent with the cloud formation observed in the sky images, hence demonstrating their usefulness for cloud monitoring. The probability distribution of the normalized SWV associated with cloudy and clear sky conditions is also analyzed, which shows that the mean values of normalized SWV associated with the former are higher. Finally, the time series of the normalized SWV is explored in relation to the solar irradiance. It is shown that the time series and spatial plots of normalized SWV are also consistent with the ratio of clear sky to measured irradiance.