1. A Shape-Restorable hierarchical polymer membrane composite system for enhanced antibacterial and antiadhesive efficiency.
- Author
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Tang Y, Qin Z, Yan X, Song Y, Zhang L, Li B, Sun H, and Wang G
- Subjects
- Silicon Dioxide chemistry, Silicon Dioxide pharmacology, Surface Properties, Membranes, Artificial, Particle Size, Bacterial Adhesion drug effects, Polymers chemistry, Polymers pharmacology, Infrared Rays, Dimethylpolysiloxanes chemistry, Dimethylpolysiloxanes pharmacology, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Escherichia coli drug effects, Staphylococcus aureus drug effects, Polyesters chemistry, Polyesters pharmacology, Graphite chemistry, Graphite pharmacology, Microbial Sensitivity Tests
- Abstract
Intelligent shape memory polymer can be potentially used in manufacturing implantable devices that enables a benign variation of implant dimensions with the external stimuli, thus effectively lowering insertion forces and evading associated risks. However, in surgical implantation, biomaterials-associated infection has imposed a huge burden to healthcare system that urgently requires an efficacious replacement of antibiotic usages. Preventing the initial attachment and harvesting a biocidal function upon native surfaces may be deemed as a preferable strategy to tackle the issues of bacterial infection. Herein, a functionalized polylactic acid (PLA) composite membrane assembled with graphene (GE, a widely used photothermal agent) was fabricated through a blending process and then polydimethylsiloxane utilized as binders to pack hydrophobic SiO
2 tightly onto polymer surface (denoted as PLA-GE/SiO2 ). Such an active platform exhibited a moderate shape-memory performance upon near-infrared (NIR) light stimulation, which was feasible for programmed deformation and shape recovery. Particularly stirring was that PLA-GE/SiO2 exerted a pronounced bacteria-killing effect under NIR illumination, 99.9 % of E. coli and 99.8 % of S. aureus were effectively eradicated in a lean period of 5 min. Furthermore, the obtained composite membrane manifested excellent antiadhesive properties, resulting in a bacteria-repelling efficacy of up to 99 % for both E. coli and S. aureus species. These findings demonstrated the potential value of PLA-GE/SiO2 as a shape-restorable platform in "kill&repel" integration strategy, further expanding its applications for clinical anti-infective treatment., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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