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A Shape-Restorable hierarchical polymer membrane composite system for enhanced antibacterial and antiadhesive efficiency.

Authors :
Tang Y
Qin Z
Yan X
Song Y
Zhang L
Li B
Sun H
Wang G
Source :
Journal of colloid and interface science [J Colloid Interface Sci] 2024 Oct 15; Vol. 672, pp. 161-169. Date of Electronic Publication: 2024 May 31.
Publication Year :
2024

Abstract

Intelligent shape memory polymer can be potentially used in manufacturing implantable devices that enables a benign variation of implant dimensions with the external stimuli, thus effectively lowering insertion forces and evading associated risks. However, in surgical implantation, biomaterials-associated infection has imposed a huge burden to healthcare system that urgently requires an efficacious replacement of antibiotic usages. Preventing the initial attachment and harvesting a biocidal function upon native surfaces may be deemed as a preferable strategy to tackle the issues of bacterial infection. Herein, a functionalized polylactic acid (PLA) composite membrane assembled with graphene (GE, a widely used photothermal agent) was fabricated through a blending process and then polydimethylsiloxane utilized as binders to pack hydrophobic SiO <subscript>2</subscript> tightly onto polymer surface (denoted as PLA-GE/SiO <subscript>2</subscript> ). Such an active platform exhibited a moderate shape-memory performance upon near-infrared (NIR) light stimulation, which was feasible for programmed deformation and shape recovery. Particularly stirring was that PLA-GE/SiO <subscript>2</subscript> exerted a pronounced bacteria-killing effect under NIR illumination, 99.9 % of E. coli and 99.8 % of S. aureus were effectively eradicated in a lean period of 5 min. Furthermore, the obtained composite membrane manifested excellent antiadhesive properties, resulting in a bacteria-repelling efficacy of up to 99 % for both E. coli and S. aureus species. These findings demonstrated the potential value of PLA-GE/SiO <subscript>2</subscript> as a shape-restorable platform in "kill&repel" integration strategy, further expanding its applications for clinical anti-infective treatment.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1095-7103
Volume :
672
Database :
MEDLINE
Journal :
Journal of colloid and interface science
Publication Type :
Academic Journal
Accession number :
38838625
Full Text :
https://doi.org/10.1016/j.jcis.2024.05.219