1,649 results on '"Diagnosi"'
Search Results
2. Disprassia verbale evolutiva (DVE): Caratteristiche cliniche, diagnosi, diagnosi differenziale e proposta di protocollo di valutazione.
- Author
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Mariani, Mirella
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EXECUTIVE function ,SPEECH apraxia ,SPEECH therapy ,SPEECH disorders ,APRAXIA ,SPEECH evaluation ,DIFFERENTIAL diagnosis ,ARTICULATION disorders ,MEDICAL protocols ,COMMUNICATIVE disorders ,HEALTH care teams ,PHONETICS ,CEREBRAL palsy ,SYMPTOMS ,CHILDREN - Abstract
Copyright of Logopedia e Comunicazione is the property of Edizioni Centro Studi Erickson SpA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
- Full Text
- View/download PDF
3. Acidosi ruminale subclinica: le basi cliniche e patogenetiche.
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Francesio, Andrea and Ferrari, Elisa
- Abstract
Copyright of Summa, Animali da Reddito is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
4. The role of EUS-FNA in the diagnosis and staging of NonSmall Cell Lung Cancer (NSCLC).
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Petrarulo, Simone, Ravaglia, Claudia, Dubini, Alessandra, Piciucchi, Sara, Spagnolo, Paolo, and Poletti, Venerino
- Abstract
A 38-year-old lifelong smoker woman with a diagnosis of lung adenocarcinoma was referred to us to perform an endoscopic ultrasound with fine-needle aspiration (EUS-FNA) procedure in order to define liver lesions suspicious for metastases. She had already performed a percutaneous procedure with ultrasound guidance, which turned out to be not diagnostic. EUS-FNA is an endoscopic technique that is increasingly acquiring a key role in the diagnosis, staging and therapy of lung cancer and lung cancer metastases. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
- View/download PDF
5. Attualità sulla peritonite infettiva felina e sui coronavirus felini.
- Author
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Boullier, Séverine and Bertagnoli, Stéphane
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
6. Proteinuria e albuminuria nelle discrasie plasmacellulari.
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Basset, Marco, Milani, Paolo, Bosoni, Tiziana, Nuvolone, Mario, Albertini, Riccardo, Merlini, Giampaolo, and Palladini, Giovanni
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PLASMA cell diseases , *IMMUNOGLOBULIN light chains , *FANCONI syndrome , *BONE marrow cells , *KIDNEY failure - Abstract
Plasma cell dyscrasias (PCDs) are characterized by a bone marrow plasma cell clone producing a monoclonal component (MC). This heterogeneous group comprehends malignant diseases as multiple myeloma (MM), conditions requiring only observation, like monoclonal gammopathy of undetermined significance (MGUS), and rarer entities where the MC causes organ dysfunction in absence of malignant PCD [(i.e. monoclonal gammopathy of clinical significance (MGCS)]. The evaluation of urine proteins has a key role in the management of PCDs, particularly quantification of proteinuria and albuminuria in the diagnostic workflow and clinical management of MGCS with renal involvement. In immunoglobulin light chain (AL) amyloidosis, proteinuria (cut-off: 0.5 g/24h) and urine albumin/creatinine ratio (UACR; cut-off: 300 mg/g) are used for diagnosis of renal involvement. These biomarkers are also included in staging systems that stratify the severity of renal involvement (proteinuria cut-off: 5 g/24h; UACR cut-off: 3 600 mg/g) and in renal response criteria (decrease of proteinuria/UACR >30% from baseline). In light chain deposition disease (LCDD), relatively low grade proteinuria (cut-off: 2 g/24h) results in higher risk of end-stage renal failure and its reduction after treatment (>50% from baseline) associates with better outcome. Finally, the presence of a MC and tubular proteinuria raises suspicion of light chain proximal tubulopathy (LCPT) with acquired Fanconi syndrome, especially in presence of other abnormalities at the urine examination (e.g. glycosuria, phosphaturia, uricosuria). The clinical laboratory, with the determination of biomarkers in urine provides crucial data in PCD management: for the diagnostic workflow, assessment of severity of the disease and evaluation of treatment effectiveness. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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7. Oestrus ovis nei piccoli ruminanti.
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Tamponi, Claudia, Carta, Carlo, Fahad, Ahmed, Cavallo, Lia, Porcu, Francesca, Scala, Antonio, and Varcasia, Antonio
- Abstract
Copyright of Summa, Animali da Reddito is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
8. Frozen shoulder: di cosa parliamo?
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Pulina, Fabrizio
- Abstract
Frozen shoulder is an idiopathic disorder of the glenohumeral joint. Over the years, many authors have endeavoured to try to identify the specific clinical parameters to diagnose FS, but even today this diagnosis is not easy, due to the complex classification, the wide spectrum of presentations, the variable course and the lack of specific tests, especially in the pre-clinical stages of the disease. [ABSTRACT FROM AUTHOR]
- Published
- 2023
9. Impact of the healthcare reorganization of the Local Health Authority services in Rieti (Italy) during the SARS-CoV-2 pandemic.
- Author
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De Luca, A., Flammini, G., Vittorini, P., Muselli, M., Mastrantonio, R., Cipollone, C., Gentile, M., Petti, A., D'Innocenzo, M., and Fabiani, L.
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MEDICAL care ,COVID-19 pandemic ,MEDICAL emergencies ,HEALTH facilities - Abstract
Background. The need to contain the spread of the SARS-CoV-2 pandemic has forced national and local organizations to define and implement targeted emergency response and management measures. As the knowledge about the infection grew, a wider range of organizational measures were deployed. Methods. This study involves the SARS-CoV-2 infected people managed by the Local Health Authority of Rieti (Italy). Diagnostic test waiting times and hospital admission rates in the Province of Rieti are investigated as the pandemic evolved. Trends were analyzed in relation to the tempora spreading of SARS-CoV-2, to the organizational actions taken by the Local Health Authority of Rieti, and to the deployment of actions across the territory. A municipalities classification of the province of Rieti was conducted after a cluster analysis based on the diagnostic test waiting times and the hospital admission rates. Results. Our findings show a declining trend, thus indicating a possible positive effect of the measures taken to contain the pandemic. The cluster analysis of the municipalities of the Province of Rieti makes evident an inhomogeneous geographical distribution of examined parameters (diagnostic test waiting times and the hospital admission rates), demonstrating the capability of Local Health Authority of Rieti to reach even the most disadvantaged areas and implying that the differences are due to the demographical variabilities. Conclusion. Despite some limitations, this study outlines the importance of management measures in response of the pandemic. These measures should adapt to social, cultural and geographical nature of the territory involved. The findings of the present study will contribute to the update of further pandemic preparedness plans of the Local Health Authorities. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Selezione di nuovi marker diagnostici per l’infezione da Dirofilaria repens mediante la tecnica phage display.
- Author
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Pękacz, Mateusz, Basałaj, Katarzyna, Kalinowska, Alicja, Klockiewicz, Maciej, Stopka, Diana, Bąska, Piotr, Długosz, Ewa, Karabowicz, Justyna, Młocicki, Daniel, Wiśniewski, Marcin, and Zawistowska‑Deniziak, Anna
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
11. I biomarcatori di infiammazione nell’enteropatia cronica canina.
- Author
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Bonnet, Laurie
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
12. Questionnaire survey sulle dirofilariosi: del cane e del gatto in Italia: seconda edizione.
- Author
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Genchi, Marco, Kramer, Laura, Rinaldi, Laura, Venco, Luigi, and Vismarra, Alice
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Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
13. Aggressività su base ansiosa nel cane.
- Author
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Michelazzi, Manuela
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
14. Toxoplasma gondii eNeospora caninum negli ovi-caprini.
- Author
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Vismarra, Alice, Genchi, Marco, and Kramer, Laura
- Abstract
Copyright of Summa, Animali da Reddito is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
15. Antielmintico resistenza nei ruminanti: mito o realtà?
- Author
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Rinaldi, Laura and Bosco, Antonio
- Abstract
Copyright of Summa, Animali da Reddito is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
16. Tumori nel coniglio, i principi per una corretta gestione.
- Author
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Sayag, David, Navarro, José Rosas, and Quinton, Jean-François
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
17. Diagnosing, Managing, and Controlling COVID-19 using Clinical Decision Support Systems: A Study to Introduce CDSS Applications
- Author
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Khadijeh Moulaei and Kambiz Bahaadinbeigy
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decision support systems ,covid-19 ,coronavirus ,diagnosi ,disease management ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Coronavirus disease (COVID-19) as an emerging disease decreases security among people from different countries. Sense of security can be raised via quick diagnosis of COVID-19, and its management and control using clinical decision support systems (CDSS) to prevent further spread of the disease. So, the aim of this study is to identify and introduce the applications of a CDSS in the diagnosis, management, and control of COVID-19. This cross-sectional study was conducted to identify and introduce the applications of CDSS in the diagnosis, management, and control of COVID-19. Based on the results of some meetings with infectious disease specialists and a general practitioner as well as reviewing the related literature, information about COVID-19 and CDSS was obtained. Then based on the information obtained, a questionnaire was designed electronically and distributed in a two-round Delphi method among 19 experts in the three fields of medical informatics, health information management, and infectious disease specialists. According to the literature and expert opinions, 35 applications of CDSS applications were identified in the four main groups of “diagnosis”, “medication”, “monitoring”, and “health services”. Eventually, a collective agreement was reached on 30 applications in the first and second rounds of Delphi. Among all the applications, the highest means were assigned to “monitoring the vital signs” and “helping diagnose infections and damaged lung tissue through CT scan”. Introducing these applications can provide general, basic knowledge of the design and implementation of clinical decision support systems in the real world to prevent irreversible complications and even many people’s death.
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- 2022
- Full Text
- View/download PDF
18. Pulci e pidocchi, stato dell’arte.
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Vismarra, Alice, Genchi, Marco, and Kramer, Laura
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
19. L'evoluzione dei modelli di psicopatologia: quali implicazioni nella clinica?
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Lang, Margherita and Michelotti, Clara
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MENTAL illness , *SYMPTOMS , *PSYCHODIAGNOSTICS , *MEDICAL personnel , *INFANTS - Abstract
The critical issues of the most widespread categorical diagnostic models, such as the ICD and the DSM, elicit some reflections: Clinicians must interface with the way psychopathology is considered and how the psychopathology model influences the diagnostic phase and the indication/contraindication to treatment. Recent research has emphasized the importance of embedding the signs and symptoms with neurobiological functioning and a developmental perspective. Recent classification systems [i.e., the Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood - DC: 0-5TM and the Research Domain Criteria - RdoC (Insel et al., 2010)] aim to identify criteria that are useful to the clinician and that overcome the limitations of traditional models. The article outlines the main points of the most up-to-date models of psychopathology, particularly how they integrate different components of the person's functioning with the developmental and neurobiological levels and the environment. These radical changes make clinicians reflect on how to use psychodiagnostic instruments: Testing was born when different models of psychopathology prevailed. The authors emphasize the importance of using more consciously existing tests, referring to a more current view of psychopathology. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
20. "No theory, no party": senza teoria non c'è cambiamento.
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Cubelli, Roberto and Balboni, Giulia
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NEUROPSYCHOLOGY , *DYSLEXIA , *NEURAL development , *COMMUNICATIONS research , *ADULTS - Abstract
The "transdiagnostic" approach to neurodevelopmental disorders can foster research and communication, but lacks theory. Without a theoretical model, identifying the causes of cognitive and behavioral disorders beyond their description and categorization is impossible. A first step towards change is to overcome the methodological dist inct ion between developmental neuropsychology and adult neuropsychology. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
21. Cambiare paradigma per i disturbi del neurosviluppo? Dalla ricerca alla pratica clinica.
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Antonietti, Alessandro, Borgatti°, Renato, and Giorgetti, Marisa
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SCIENTIFIC community , *NEURAL development , *RESEARCH questions , *OPEN-ended questions , *COMORBIDITY - Abstract
The paper provides the scientific community and the clinic practitioners dealing with neurodevelopmental disorders with a list of open questions about research and diagnosis. Such questions are elicited by the evidence coming from neuroscience investigations and from the outline of a different framework to understand disorders with onset in the developmental period. The broad heterogeneity that characterizes the diagnostic categories of neurodevelopmental disorders has favored the emergence of constructs referable to complexity, multidimensionality, and comorbidity. The reflection is carried-out according to the Research Domain Criteria (RDoC) approach. RDoC is a dimensional diagnostic system with the aim of shifting the focus of research and clinical practice away from the existing diagnostic categories towards dimensions of observable behavior and neurobiological measures. The transdiagnostic perspective of the RDoc approach is used here both as a possible criticism of the dominant research paradigms and as a challenge to rethink neurodevelopmental disorders and as a potential solution to intercept the specificities of the phenotypes. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
- View/download PDF
22. Un nuovo paradigma: impressioni sulla clinica contemporanea.
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Rosaria Chieffo, Daniela Pia
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DEVELOPMENTAL psychology , *COGNITIVE ability , *COGNITIVE development , *TOUCH screens , *DIGITAL natives - Abstract
In recent years, and in particular in the current post-pandemic scenario, the need for a diagnostic paradigm shift has been highlighted for developmental psychology, and mainly for neurodevelopmental disorders. Defining the needs of clinical populations also in relation to any comorbidities from a bio-psychosocial perspective comes to light. In particular, it is interesting to consider how the advent of new technologies has impacted the development of some cognitive abilities especially in digital natives. The use of virtual screens, touchscreens, and digital technologies should be considered as a fundamental element in the investigation of new cognitive profiles. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
23. Cestodi del cane e del gatto.
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Tamponi, Claudia, Varcasia, Antonio, Cavallo, Lia, Dessì, Giorgia, Scala, Antonio, Nonnis, Francesca, and Pentcheva, Plamena
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
24. Artificial intelligence–based algorithms for the diagnosis of prostate cancer: A systematic review
- Author
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Marletta, S, Eccher, A, Martelli, F, Santonicco, N, Girolami, I, Scarpa, A, Pagni, F, L’Imperio, V, Pantanowitz, L, Gobbo, S, Seminati, D, Dei Tos, A, Parwani, A, Marletta, Stefano, Eccher, Albino, Martelli, Filippo Maria, Santonicco, Nicola, Girolami, Ilaria, Scarpa, Aldo, Pagni, Fabio, L’Imperio, Vincenzo, Pantanowitz, Liron, Gobbo, Stefano, Seminati, Davide, Dei Tos, Angelo Paolo, Parwani, Anil, Marletta, S, Eccher, A, Martelli, F, Santonicco, N, Girolami, I, Scarpa, A, Pagni, F, L’Imperio, V, Pantanowitz, L, Gobbo, S, Seminati, D, Dei Tos, A, Parwani, A, Marletta, Stefano, Eccher, Albino, Martelli, Filippo Maria, Santonicco, Nicola, Girolami, Ilaria, Scarpa, Aldo, Pagni, Fabio, L’Imperio, Vincenzo, Pantanowitz, Liron, Gobbo, Stefano, Seminati, Davide, Dei Tos, Angelo Paolo, and Parwani, Anil
- Abstract
Objectives: The high incidence of prostate cancer causes prostatic samples to significantly affect pathology laboratories workflow and turnaround times (TATs). Whole-slide imaging (WSI) and artificial intelligence (AI) have both gained approval for primary diagnosis in prostate pathology, providing physicians with novel tools for their daily routine. Methods: A systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was carried out in electronic databases to gather the available evidence on the application of AI-based algorithms to prostate cancer. Results: Of 6290 articles, 80 were included, mostly (59%) dealing with biopsy specimens. Glass slides were digitized to WSI in most studies (89%), roughly two-thirds of which (66%) exploited convolutional neural networks for computational analysis. The algorithms achieved good to excellent results about cancer detection and grading, along with significantly reduced TATs. Furthermore, several studies showed a relevant correlation between AI-identified histologic features and prognostic predictive variables such as biochemical recurrence, extraprostatic extension, perineural invasion, and disease-free survival. Conclusions: The published evidence suggests that AI can be reliably used for prostate cancer detection and grading, assisting pathologists in the time-consuming screening of slides. Further technologic improvement would help widening AI's adoption in prostate pathology, as well as expanding its prognostic predictive potential.
- Published
- 2024
25. The diagnostic approach and management of hypertension in the emergency department
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Manolis, A, Kallistratos, M, Koutsaki, M, Doumas, M, Poulimenos, L, Parissis, J, Polyzogopoulou, E, Pittaras, A, Muiesan, M, Mancia, G, Manolis A. J., Kallistratos M. S., Koutsaki M., Doumas M., Poulimenos L. E., Parissis J., Polyzogopoulou E., Pittaras A., Muiesan M. L., Mancia G., Manolis, A, Kallistratos, M, Koutsaki, M, Doumas, M, Poulimenos, L, Parissis, J, Polyzogopoulou, E, Pittaras, A, Muiesan, M, Mancia, G, Manolis A. J., Kallistratos M. S., Koutsaki M., Doumas M., Poulimenos L. E., Parissis J., Polyzogopoulou E., Pittaras A., Muiesan M. L., and Mancia G.
- Abstract
Hypertension urgency and emergency represents a challenging condition in which clinicians should determine the assessment and/or treatment of these patients. Whether the elevation of blood pressure (BP) levels is temporary, in need of treatment, or reflects a chronic hypertensive state is not always easy to unravel. Unfortunately, current guidelines provide few recommendations concerning the diagnostic approach and treatment of emergency department patients presenting with severe hypertension. Target organ damage determines: the timeframe in which BP should be lowered, target BP levels as well as the drug of choice to use. It's important to distinguish hypertensive emergency from hypertensive urgency, usually a benign condition that requires more likely an outpatient visit and treatment.
- Published
- 2024
26. Radiomics and liver: Where we are and where we are headed?
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Maino, C, Vernuccio, F, Cannella, R, Franco, P, Giannini, V, Dezio, M, Pisani, A, Blandino, A, Faletti, R, De Bernardi, E, Ippolito, D, Gatti, M, Inchingolo, R, Maino C., Vernuccio F., Cannella R., Franco P. N., Giannini V., Dezio M., Pisani A. R., Blandino A. A., Faletti R., De Bernardi E., Ippolito D., Gatti M., Inchingolo R., Maino, C, Vernuccio, F, Cannella, R, Franco, P, Giannini, V, Dezio, M, Pisani, A, Blandino, A, Faletti, R, De Bernardi, E, Ippolito, D, Gatti, M, Inchingolo, R, Maino C., Vernuccio F., Cannella R., Franco P. N., Giannini V., Dezio M., Pisani A. R., Blandino A. A., Faletti R., De Bernardi E., Ippolito D., Gatti M., and Inchingolo R.
- Abstract
Hepatic diffuse conditions and focal liver lesions represent two of the most common scenarios to face in everyday radiological clinical practice. Thanks to the advances in technology, radiology has gained a central role in the management of patients with liver disease, especially due to its high sensitivity and specificity. Since the introduction of computed tomography (CT) and magnetic resonance imaging (MRI), radiology has been considered the non-invasive reference modality to assess and characterize liver pathologies. In recent years, clinical practice has moved forward to a quantitative approach to better evaluate and manage each patient with a more fitted approach. In this setting, radiomics has gained an important role in helping radiologists and clinicians characterize hepatic pathological entities, in managing patients, and in determining prognosis. Radiomics can extract a large amount of data from radiological images, which can be associated with different liver scenarios. Thanks to its wide applications in ultrasonography (US), CT, and MRI, different studies were focused on specific aspects related to liver diseases. Even if broadly applied, radiomics has some advantages and different pitfalls. This review aims to summarize the most important and robust studies published in the field of liver radiomics, underlying their main limitations and issues, and what they can add to the current and future clinical practice and literature.
- Published
- 2024
27. CARE-radiology statement explanation and elaboration: reporting guideline for radiological case reports
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Wang, M, Luo, X, Xiao, X, Zhang, L, Wang, Q, Wang, S, Wang, X, Xue, H, Chen, Y, Lei, J, Štupnik, T, Scarci, M, Fiorelli, A, Laisaar, T, Fruscio, R, Elkhayat, H, Novoa, N, Davoli, F, Waseda, R, Estill, J, Norris, S, Riley, D, Tian, J, Wang, Mengshu, Luo, Xufei, Xiao, Xiaojuan, Zhang, Linlin, Wang, Qi, Wang, Shiyu, Wang, Ximing, Xue, Huadan, Zhang, Longjiang, Chen, Yaolong, Lei, Junqiang, Štupnik, Tomaž, Scarci, Marco, Fiorelli, Alfonso, Laisaar, Tanel, Fruscio, Robert, Elkhayat, Hussein, Novoa, Nuria M, Davoli, Fabio, Waseda, Ryuichi, Estill, Janne, Norris, Susan L, Riley, David S, Tian, Jinhui, Wang, M, Luo, X, Xiao, X, Zhang, L, Wang, Q, Wang, S, Wang, X, Xue, H, Chen, Y, Lei, J, Štupnik, T, Scarci, M, Fiorelli, A, Laisaar, T, Fruscio, R, Elkhayat, H, Novoa, N, Davoli, F, Waseda, R, Estill, J, Norris, S, Riley, D, Tian, J, Wang, Mengshu, Luo, Xufei, Xiao, Xiaojuan, Zhang, Linlin, Wang, Qi, Wang, Shiyu, Wang, Ximing, Xue, Huadan, Zhang, Longjiang, Chen, Yaolong, Lei, Junqiang, Štupnik, Tomaž, Scarci, Marco, Fiorelli, Alfonso, Laisaar, Tanel, Fruscio, Robert, Elkhayat, Hussein, Novoa, Nuria M, Davoli, Fabio, Waseda, Ryuichi, Estill, Janne, Norris, Susan L, Riley, David S, and Tian, Jinhui
- Abstract
Despite the increasing number of radiological case reports, the majority lack a standardised methodology of writing and reporting. We therefore develop a reporting guideline for radiological case reports based on the CAse REport (CARE) statement. We established a multidisciplinary group of experts, comprising 40 radiologists, methodologists, journal editors and researchers, to develop a reporting guideline for radiological case reports according to the methodology recommended by the Enhancing the QUAlity and Transparency Of health Research network. The Delphi panel was requested to evaluate the significance of a list of elements for potential inclusion in a guideline for reporting mediation analyses. By reviewing the reporting guidelines and through discussion, we initially drafted 46 potential items. Following a Delphi survey and discussion, the final CARE-radiology checklist is comprised of 38 items in 16 domains. CARE-radiology is a comprehensive reporting guideline for radiological case reports developed using a rigorous methodology. We hope that compliance with CARE-radiology will help in the future to improve the completeness and quality of case reports in radiology.
- Published
- 2024
28. Neuropsychological profile of chronic pain: implications for diagnosis and treatments
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Telesca, A, ROMERO LAURO, LEONOR JOSEFINA, TELESCA, ALESSANDRA, Telesca, A, ROMERO LAURO, LEONOR JOSEFINA, and TELESCA, ALESSANDRA
- Abstract
Chronic pain is a complex phenomenon with a multidimensional nature that involves both biology and psychology, as well as socio-cultural influences. While its primary function is to protect us from environmental and endogenous dangers, ensuring the survival of the species, when it becomes chronic it can be threatening to us, causing important physical and mental burden. In this complex phenomenon, psychology may play two important roles: the first is to provide a key to understanding the mechanisms beyond the chronification by exploring the various domains related to cognition, behaviours and psychological functions. The second role deals with non-invasive and non-pharmacological therapeutic approaches that, also by mean of psychology, can contribute to improving patients' conditions and the socio-economic management of the burden of chronic pain. In this framework, my research focused on both of these aspects. The first chapter will introduce the context of chronic pain, the specific characteristics of the different clinical conditions characterised by it, and provide a brief description of the main pathways connecting the central nervous system with the periphery, and vice versa. Furthermore, the neural correlates typical of chronic pain conditions will be briefly presented, and the main therapeutic approaches, currently known and applied in the broad field of chronic pain, will be illustrated. The second chapter will be focused on presenting the different experimental studies constituting my research activity. In particular, the first paragraph will present four research works focused on cognitive, behavioural and psychological functioning of three different populations affected by chronic pain, namely (i) small fibre neuropathy, a specific painful peripheral neuropathy, (ii) chronic primary pain conditions, and (iii) cluster headache. The results will address the issue of better characterizing their psychological functioning and will support the effective need f, Chronic pain is a complex phenomenon with a multidimensional nature that involves both biology and psychology, as well as socio-cultural influences. While its primary function is to protect us from environmental and endogenous dangers, ensuring the survival of the species, when it becomes chronic it can be threatening to us, causing important physical and mental burden. In this complex phenomenon, psychology may play two important roles: the first is to provide a key to understanding the mechanisms beyond the chronification by exploring the various domains related to cognition, behaviours and psychological functions. The second role deals with non-invasive and non-pharmacological therapeutic approaches that, also by mean of psychology, can contribute to improving patients' conditions and the socio-economic management of the burden of chronic pain. In this framework, my research focused on both of these aspects. The first chapter will introduce the context of chronic pain, the specific characteristics of the different clinical conditions characterised by it, and provide a brief description of the main pathways connecting the central nervous system with the periphery, and vice versa. Furthermore, the neural correlates typical of chronic pain conditions will be briefly presented, and the main therapeutic approaches, currently known and applied in the broad field of chronic pain, will be illustrated. The second chapter will be focused on presenting the different experimental studies constituting my research activity. In particular, the first paragraph will present four research works focused on cognitive, behavioural and psychological functioning of three different populations affected by chronic pain, namely (i) small fibre neuropathy, a specific painful peripheral neuropathy, (ii) chronic primary pain conditions, and (iii) cluster headache. The results will address the issue of better characterizing their psychological functioning and will support the effective need f
- Published
- 2024
29. Estimating risk of endometrial malignancy and other intracavitary uterine pathology in women without abnormal uterine bleeding using IETA-1 multinomial regression model: validation study
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Heremans, R, Wynants, L, Valentin, L, Leone, F, Pascual, M, Fruscio, R, Testa, A, Buonomo, F, Guerriero, S, Epstein, E, Bourne, T, Timmerman, D, Van den Bosch, T, Leone, FPG, Pascual, MA, Testa, AC, Heremans, R, Wynants, L, Valentin, L, Leone, F, Pascual, M, Fruscio, R, Testa, A, Buonomo, F, Guerriero, S, Epstein, E, Bourne, T, Timmerman, D, Van den Bosch, T, Leone, FPG, Pascual, MA, and Testa, AC
- Abstract
Objectives: To assess the ability of the International Endometrial Tumor Analysis (IETA)-1 polynomial regression model to estimate the risk of endometrial cancer (EC) and other intracavitary uterine pathology in women without abnormal uterine bleeding. Methods: This was a retrospective study, in which we validated the IETA-1 model on the IETA-3 study cohort (n = 1745). The IETA-3 study is a prospective observational multicenter study. It includes women without vaginal bleeding who underwent a standardized transvaginal ultrasound examination in one of seven ultrasound centers between January 2011 and December 2018. The ultrasonography was performed either as part of a routine gynecological examination, during follow-up of non-endometrial pathology, in the work-up before fertility treatment or before treatment for uterine prolapse or ovarian pathology. Ultrasonographic findings were described using IETA terminology and were compared with histology, or with results of clinical and ultrasound follow-up of at least 1 year if endometrial sampling was not performed. The IETA-1 model, which was created using data from patients with abnormal uterine bleeding, predicts four histological outcomes: (1) EC or endometrial intraepithelial neoplasia (EIN); (2) endometrial polyp or intracavitary myoma; (3) proliferative or secretory endometrium, endometritis, or endometrial hyperplasia without atypia; and (4) endometrial atrophy. The predictors in the model are age, body mass index and seven ultrasound variables (visibility of the endometrium, endometrial thickness, color score, cysts in the endometrium, non-uniform echogenicity of the endometrium, presence of a bright edge, presence of a single dominant vessel). We analyzed the discriminative ability of the model (area under the receiver-operating-characteristics curve (AUC); polytomous discrimination index (PDI)) and evaluated calibration of its risk estimates (observed/expected ratio). Results: The median age of the women in the
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- 2024
30. La funzione del reato nell'autismo ad alto funzionamento ed implicazioni clinico forensi Aspetti di diagnosi differenziale e comorbilità psichiatrica
- Author
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Virginia D'Angelo
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autismo ,diagnosi ,comorbilità ,Pathology ,RB1-214 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Il presente lavoro analizza la funzione del reato nell’autismo ad alto funzionamento esaminando le molteplici aree psico-emotive coinvolte in questo processo. Si approfondiscono gli aspetti di diagnosi differenziale e comorbilità psichiatrica con alcuni disturbi maggiormente correlati all’autismo di livello 1. Si evidenziano, dunque, le conseguenti implicazioni sul piano clinico e forense. L’elaborato parte dall’esame di come il sistema giuridico italiano si interfaccia con il disturbo mentale. È messo in luce il ruolo che il sistema giuridico attribuisce alle neuroscienze nell’analisi del profilo di responsabilità di un soggetto con disturbo mentale ed, in particolare, di un soggetto con autismo di livello 1 che commette un reato. A tale proposito è esaminata la funzione dei reati più comuni. Si evidenziano le differenze dell’autismo di livello 1 con il disturbo antisociale e schizofrenico. L’attenzione è sull’esplorazione della sintomatologia clinica in termini di funzione. Attraverso un’analisi critica degli studi evidenziati in letteratura, è descritto il fattore fondamentale per la corretta individuazione della diagnosi differenziale e, di conseguenza, della comorbilità psichiatrica. Esso è rappresentato dall’esame del processo difensivo dal quale i sintomi hanno origine. Una stessa manifestazione sintomatologica può, infatti, rappresentare problematiche e patologie differenti. Il focus è dunque posto sull’importanza di una valutazione clinico forense particolarmente approfondita in cui sono esaminati i meccanismi di difesa. La finalità di questo articolo è evidenziare l’opportunità di applicare nel contesto giuridico nuovi e più completi strumenti di valutazione e diagnosi.
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- 2021
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31. La performance dell’ecografia nella diagnosi di carcinoma midollare della tiroide è subottimale. Nuovi dati evidence-based
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Caironi, Verdiana, Ferrarazzo, Giulia, and Trimboli, Pierpaolo
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- 2023
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32. Alcune riflessioni sul modello formativo organizzato sulla valutazione e la diagnosi nel contesto scuola.
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Valentini, Simone
- Abstract
The school and its clients, pupils, and families are facing critical change. The presence of foreign students and cultural diversity is growing. These changes are accompanied by an exponential growth in the use of diagnoses, with the production of an almost infinite descriptive taxonomy: disabilities, learning difficulties, and cultural differences blend, all becoming deficits. Without a clear definition of the problems that the school context, as a system of productive relationships, is facing, one moves towards confusion that leads to placing the cause of every complex educational relationship on the individual pupils, with the production of an infinite number of deficit certificates. In this scenery, diagnosis becomes a tool for activating resources, with the imagination - starting from those - of being able to solve a vast range of problems which, upon closer inspection, are problems of coexistence. This dynamic makes it difficult for the school to think about its complexity, causing it lose sight of its mandate: to train to the wider social context, grasp its changes, and promote them. In this work, an intervention proposal is made which uses the reference to a psychology of the individual-context relationship, based on the hypothesis of the unconscious collusive dynamic that organizes the social and organizational relationship in the school, useful for reading the changes taking place and promoting its objectives of development. [ABSTRACT FROM AUTHOR]
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- 2022
33. “Revolution in asma”: un nuovo paradigma nei programmi di aggiornamento e implementazione delle linee guida per la gestione dell’asma.
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Vaghi, Adriano, Asero, Riccardo, Calderazzo, Massimo, Carone, Mauro, Michele, Fausto De, Gasparini, Stefano, Harari, Sergio, Insalaco, Giuseppe, Micheletto, Claudio, Musarra, Antonino, Poletti, Venerino, Pomponio, Giovanni, Scala, Raffaele, Tognella, Silvia, Zerbino, Carlo, and Zuccatosta, Lina
- Abstract
Introduction. Asthma is one of the most common chronic diseases in both pediatric age and adulthood, often underdiagnosed and undertreated. Over the past 20 years, numerous guidelines have been published with the aim of translating evidence into recommendations for good clinical practice; however, their impact was modest. The multilevel training program “Revolution in asthma” was created with the dual objective of improving the knowledge of the main guidelines on asthma and investigating the level of agreement of the participants with the recommendations of the guidelines, as well as their real-life application. Materials and methods. The survey was conducted from February to October 2021 on a representative sample of 400 Italian general practitioners, pulmonologists and algologists. Four guidelines (BTS/SIGN, NICE, AEPP-NHLBI-EPR and GINA) were compared and the concordances/ discrepancies between the recommendations of the guidelines relating to seven thematic areas were analyzed. Agreement/disagreement with the recommendations was measured with a Likert scale. The level of adherence in clinical practice was also assessed through questions aimed at estimating participants’ “opinions/beliefs” (as indicator of self-efficacy, i.e., confidence that the recommendations can be applied in daily practice). Results and conclusions. This e-learning project increased the participants’ guidelines knowledge (at the end of the course, 80% of the participants thought it was more useful to use several guidelines than one). The analysis highlighted the areas of agreement with the guidelines, and the “grey areas”, i.e. the areas with moderate agreement, such as patients monitoring and PEF use. Besides, barriers that interfere with the application of the recommendations into clinical practice were identified. In conclusion, the project allowed the participants to re-elaborate their own “mental guidelines” and to compare them with the published ones, thus driving a paradigm shift in everyday clinical practice. [ABSTRACT FROM AUTHOR]
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- 2022
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34. Protozoi intestinali del gatto, non solo coccidi.
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Morganti, Giulia, Colombo, Mariasole, Rigamonti, Giulia, and Morelli, Simone
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
35. L’algoritmo ISarcoPRM per la diagnosi di sarcopenia.
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Moneta, Beatrice, Salce, Gregorio, Ricci, Vincenzo, Gervasoni, Fabrizio, and Andreoli, Arnaldo
- Abstract
In early 2021, the ISarcoPRM – the special interest group on sarcopenia of the International Society of Physical and Rehabilitation Medicine (ISPRM) – proposed a new diagnostic algorithm that enables effective and early diagnosis of sarcopenia. The diagnosis is made through four tests, all of which can be administered in both inpatient and outpatient settings. A validated diagnostic algorithm for sarcopenia contributes to the standardization of clinical practices and promotes better communication among health professionals. This allows to obtain consistent and comparable results in different healthcare facilities, facilitating clinic research and the identification of the best therapeutic approaches to counteract this condition. [ABSTRACT FROM AUTHOR]
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- 2023
36. Il DNA tumorale circolante, un biomarker del futuro in oncologia veterinaria.
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Hédan, Benoît and Prouteau, Anaïs
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
37. I marker tumorali.
- Author
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Vazquez, Léa
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
38. Diagnosing, Managing, and Controlling COVID-19 using Clinical Decision Support Systems: A Study to Introduce CDSS Applications.
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Moulaei, Khadijeh and Bahaadinbeigy, Kambiz
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CLINICAL decision support systems ,MEDICAL informatics ,COVID-19 ,DIAGNOSIS ,INFORMATION resources management ,COMMUNICABLE diseases ,COLLECTIVE labor agreements - Abstract
Coronavirus disease (COVID-19) as an emerging disease decreases security among people from different countries. Sense of security can be raised via quick diagnosis of COVID-19, and its management and control using clinical decision support systems (CDSS) to prevent further spread of the disease. So, the aim of this study is to identify and introduce the applications of a CDSS in the diagnosis, management, and control of COVID-19. This cross-sectional study was conducted to identify and introduce the applications of CDSS in the diagnosis, management, and control of COVID-19. Based on the results of some meetings with infectious disease specialists and a general practitioner as well as reviewing the related literature, information about COVID-19 and CDSS was obtained. Then based on the information obtained, a questionnaire was designed electronically and distributed in a two-round Delphi method among 19 experts in the three fields of medical informatics, health information management, and infectious disease specialists. According to the literature and expert opinions, 35 applications of CDSS applications were identified in the four main groups of "diagnosis", "medication", "monitoring", and "health services". Eventually, a collective agreement was reached on 30 applications in the first and second rounds of Delphi. Among all the applications, the highest means were assigned to "monitoring the vital signs" and "helping diagnose infections and damaged lung tissue through CT scan". Introducing these applications can provide general, basic knowledge of the design and implementation of clinical decision support systems in the real world to prevent irreversible complications and even many people's death. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
- View/download PDF
39. La diagnosi della mastite e le nuove normative in tema di terapia antibiotica Prima parte.
- Author
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Zecconi, Alfonso and Cipolla, Micaela
- Abstract
Copyright of Summa, Animali da Reddito is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
40. La diagnosi della mastite e le nuove normative in tema di terapia antibiotica Seconda parte .
- Author
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Zecconi, Alfonso and Cipolla, Micaela
- Abstract
Copyright of Summa, Animali da Reddito is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
41. Le nuove tecnologie in sala di mungitura e la diagnosi di mastite: una possibile alternativa al laboratorio?.
- Author
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Zecconi, Alfonso and Cipolla, Micaela
- Abstract
Copyright of Summa, Animali da Reddito is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
42. Come cambia l'immagine dello psicologo entro una cultura della convivenza in crisi: Una ricerca.
- Author
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Paniccia, Rosa Maria and Dolcetti, Francesca Romana
- Abstract
The presented research explores the expectations of a group of 40 Roman citizens about the psychologist. Open interviews were conducted and analyzed through the ETA (Emotional Text Analysis). In the 2000s, research on this subject continued to point out, alongside the one concerning a form of psychotherapy aimed at the individual, the presence of a demand, addressed to the psychologist, to intervene on the crisis in relationships and in systems of coexistence. The University, the Order of Psychologists, the professional community more generally seem not to have given an adequate response. While the perception of a crisis in the systems of coexistence seems to grow and the demand concerning it is confirmed in this research, at the same time the connection with the psychological profession loses strength. The fact remains that the demand persists, requiring intervention initiatives from a psychology capable of proposing them. [ABSTRACT FROM AUTHOR]
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- 2022
43. Acromegalia: differenze di sesso e genere
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Gagliardi, Irene, Aliberti, Ludovica, Medici, Margherita, Zatelli, Maria Chiara, and Ambrosio, Maria Rosaria
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- 2023
- Full Text
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44. Diagnosi di laboratorio delle zoonosi da parassiti intestinali del cane e del gatto.
- Author
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Simonato, Giulia, Morelli, Simone, Colombo, Mariasole, Grillini, Marika, Cesare, Angela Di, Traversa, Donato, and di Regalbono, Antonio Frangipane
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
45. Öyküsünde karbonmonoksit zehirlenmesi olan geç başlangıçlı psikotik bozukluk: Bir olgu sunumu.
- Author
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Salihoğlu, Gözde and Hocaoğlu, Çiçek
- Abstract
Carbon monoxide (CO) poisoning can cause severe neuropsychiatric disorders. However, no sufficient attention has been paid to this issue in literature. The definition, treatment and clinical course of neuropsychiatric symptoms that occur especially after poisoning are not known exactly. In the studies conducted to date, neurological symptoms, cognitive, mood and personality disorders have been observed in the cases years after CO poisoning. However, the hypotheses regarding the etiopathology of long-term neuropsychiatric findings have not clarified the subject completely. The interaction of environmental and neurobiological complex factors related to the patient's clinical symptomatology may be a risk factor for the emergence of long-term neuropsychiatric disorders. In this study, a 45-year-old female patient who presented to our clinic with late-onset psychotic symptoms and suffered from CO poisoning 15 years ago is presented in the light of literature findings. After CO poisoning, a close follow-up with neuropsychiatric evaluation and regular neuroimaging should be planned. The diagnosis and treatment of neuropsychiatric symptoms and disorders caused by CO poisoning, which is the leading cause of intoxication-related deaths all over the world, is important. Clinicians should be careful about medical evaluations in patients with atypical features and late-onset psychotic complaints and a history of CO poisoning. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
46. Significato clinico delle perdite vaginali nel bovino da latte.
- Author
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Gnemmi, Giovanni, Gnemmi, Benedetta, and Maraboli, Cristina
- Abstract
Copyright of Summa, Animali da Reddito is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
47. Dermatite allergica alla puntura di pulce: diagnosi e terapie.
- Author
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Graziano, Lisa
- Abstract
Copyright of Summa, Animali da Compagnia is the property of Point Veterinaire Italie s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
48. Radionuclide Imaging of Infective Endocarditis
- Author
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Ferro, Paola, Boni, Roberto, Bartoli, Francesco, Lazzeri, Francesca, Slart, Riemer H J A, Erba, Paola A, Ferro, P, Boni, R, Bartoli, F, Lazzeri, F, Slart, R, and Erba, P
- Subjects
diagnosi ,Duke/ESC criteria ,Labeled leukocyte (WBC) imaging ,PET/CT imaging ,Echocardiography ,Infections associated with cardiovascular implantable electronic devices (CIED) ,General Medicine ,SPECT/CT imaging ,Cardiology and Cardiovascular Medicine ,Infectious endocarditis (IE) - Abstract
Infective endocarditis (IE) is associated with high morbidity and mortality. Early diagnosis is crucial for adequate patient management. Due to difficulties in the diagnosis, a multidisciplinary discussion in addition to the integration of clinical signs, microbiology data, and imaging data is used. Imaging, including echocardiography, molecular imaging techniques, and coronary CT angiography (CTA) is central to detect infections involving heart valves and implanted cardiovascular devices, also allowing for early detection of septic emboli and metastatic. This article describes the main clinical application of white blood cell SPECT/CT and [18F]FDG-PET/CT and CTA in IE and infections associated with cardiovascular implantable electronic devices.
- Published
- 2023
49. La sclerosi multipla in età pediatrica e adolescenziale
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Carrozzi, Marco, Iacono, Alessandra, Gortani, Giulia, Piscaglia, Maria Grazia, Marchetti, Federico, Barbi, Egidio, Carrozzi, Marco, Iacono, Alessandra, Gortani, Giulia, Piscaglia, Maria Grazia, Marchetti, Federico, and Barbi, Egidio
- Subjects
Diagnosis ,Pediatrics, Perinatology and Child Health ,Disease-modifying treatment ,Review ,Paediatric-onset multiple sclerosis ,Paediatric-onset multiple sclerosi ,Diagnosi - Abstract
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelin of the brain and spinal cord; it is characterized by recurrent episodes of demyelination in the central nervous system. Paediatric-onset multiple sclerosis (POMS) is a rare disease, with an estimated frequency of approximately 0.05-2.85 per 100,000 children. The diagnosis requires the spatial and temporal dissemination of the disease with clinical evaluation and with laboratory tests such as oligoclonal bands in the liquor and MRI of the brain and spinal cord. The treatment of the acute episode involves cortisone in high doses, then the immunomodulatory treatment (disease-modifying treatment - DMT) is started to prevent the recurrence of the episodes with consequent stabilization of the lesions that could anticipate the time of permanent disability. Hence, the paper aims to review the literature on POMS to guide physicians on the current understanding of its diagnosis and management.
- Published
- 2023
50. The molecular landscape of breast mucoepidermoid carcinoma
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Konstantinos Venetis, Elham Sajjadi, Mariia Ivanova, Silvia Andaloro, Simona Pessina, Chiara Zanetti, Alberto Ranghiero, Gabriele Citelli, Chiara Rossi, Marco Lucioni, Umberto Malapelle, Fabio Pagni, Massimo Barberis, Elena Guerini‐Rocco, Giuseppe Viale, Nicola Fusco, Venetis, Konstantino, Sajjadi, Elham, Ivanova, Mariia, Andaloro, Silvia, Pessina, Simona, Zanetti, Chiara, Ranghiero, Alberto, Citelli, Gabriele, Rossi, Chiara, Lucioni, Marco, Malapelle, Umberto, Pagni, Fabio, Barberis, Massimo, Guerini-Rocco, Elena, Viale, Giuseppe, Fusco, Nicola, Venetis, K, Sajjadi, E, Ivanova, M, Andaloro, S, Pessina, S, Zanetti, C, Ranghiero, A, Citelli, G, Rossi, C, Lucioni, M, Malapelle, U, Pagni, F, Barberis, M, Guerini-Rocco, E, Viale, G, and Fusco, N
- Subjects
diagnosi ,Cancer Research ,breast cancer ,Oncology ,molecular profiling ,rare tumor ,triple-negative breast cancer ,biomarker ,Radiology, Nuclear Medicine and imaging ,mucoepidermoid carcinoma - Abstract
Mucoepidermoid carcinoma (MEC) of the breast is an extremely rare salivary gland-type tumor characterized by epidermoid, basaloid, intermediate, and/or mucinous cells arranged in solid and cystic patterns. Despite their triple-negative phenotype, breast MECs are generally considered low-risk malignancies but their biology is largely unexplored; therefore, guidelines for clinical management are lacking. Here, we sought to characterize the molecular landscape of breast MECs. Thirteen cases were histologically reviewed, characterized for tumor-infiltrating lymphocytes (TILs), and were subjected to immunohistochemistry for programmed death-ligand 1 (PD-L1, clone 22C3), EGFR, and amphiregulin (AREG). Rearrangements in MAML2 and EWSR1 were investigated by fluorescent in situ hybridization. Targeted next-generation sequencing of 161 genes was performed on eight cases. Most MECs had low histological grade (n = 10, 77%), with the presence of TILs (n = 9/12; 75%) and PD-L1 combined positive score ranging from 10 to 20 (n = 4/6; 67%). All cases showed EGFR and AREG overexpression and were fusion negative. Enrichment of genetic alterations was observed in PI3K/AKT/mTOR and cell cycle regulation pathways, while only one case harbored TP53 mutations. This is the first study providing extensive molecular data on breast MECs and the largest collection of cases available to date in the literature. Breast MECs lack TP53 mutations found in high-grade forms of triple-negative breast cancers and MAML2 or EWSR1 rearrangements pathognomonic of salivary MECs. Triple-negativity and PD-L1 positivity suggest a window of opportunity for immunotherapy in these patients. The EGFR/AREG axis activation, coupled with the mutational patterns in PI3K/AKT/mTOR and cell cycle pathways warrants caution in considering MECs as low-risk neoplasms.
- Published
- 2023
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