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504 results on '"Di Tommaso, M."'

5. PO-2301 Interobserver variability of target volumes in Accelerated Partial Breast Irradiation

Author

Borgia, M., primary, Lucarelli, M., additional, Nuzzo, M., additional, Ursini, L.A., additional, Caravatta, L., additional, Augurio, A., additional, Di Tommaso, M., additional, Raspanti, D., additional, Aristei, C., additional, Palumbo, I., additional, Perrucci, E., additional, Di Lena, L., additional, Becchetti, A.G., additional, and Genovesi, D., additional

Published
2023
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16. Neonatal outcomes in an expectantly managed prospective cohort of late preterm prelabor rupture of membranes

Author

Benuzzi, M., primary, Tramontano, A.L., additional, Menichini, D., additional, Semprini, M., additional, Del Villano, N., additional, Zinani, I., additional, Berardi, A., additional, Rigoli, F., additional, Costa, P., additional, Consonni, S., additional, Di Tommaso, M., additional, Orlandi, G., additional, Strambi, N., additional, Facchinetti, F., additional, Locatelli, A., additional, Chiossi, G., additional, and Monari, F., additional

Published
2023
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21. Valacyclovir for prevention and treatment of fetal cmv infection: Inclusion in the law 648/96 list and launch of the italian multicentre observational prospective study “megal-itali”

Author

Zammarchi, L, Lazzarotto, T, Di Tommaso, M, Tomasoni, L, Pasquini, L, Galli, L, Simonazzi, G, Castelli, F, Borchi, B, Campolmi, I, Ornaghi, S, Bartoloni, A, Andreoni, M, Pagano, I, Petraglia, S, Ramenghi, L, Clerici, P, Tavio, M, Trotta, M, Zammarchi L., Lazzarotto T., Di Tommaso M., Tomasoni L., Pasquini L., Galli L., Simonazzi G., Castelli F., Borchi B., Campolmi I., Ornaghi S., Bartoloni A., Andreoni M., Pagano I., Petraglia S., Ramenghi L., Clerici P., Tavio M., Trotta M., Zammarchi, L, Lazzarotto, T, Di Tommaso, M, Tomasoni, L, Pasquini, L, Galli, L, Simonazzi, G, Castelli, F, Borchi, B, Campolmi, I, Ornaghi, S, Bartoloni, A, Andreoni, M, Pagano, I, Petraglia, S, Ramenghi, L, Clerici, P, Tavio, M, Trotta, M, Zammarchi L., Lazzarotto T., Di Tommaso M., Tomasoni L., Pasquini L., Galli L., Simonazzi G., Castelli F., Borchi B., Campolmi I., Ornaghi S., Bartoloni A., Andreoni M., Pagano I., Petraglia S., Ramenghi L., Clerici P., Tavio M., and Trotta M.

Published
2021

22. Neonatal outcomes and risk of neonatal sepsis in an expectantly managed cohort of late preterm prelabor rupture of membranes

Author

Chiossi, G, Di Tommaso, M, Monari, F, Consonni, S, Strambi, N, Zoccoli, S, Seravalli, V, Comerio, C, Betti, M, Cappello, A, Vergani, P, Facchinetti, F, Locatelli, A, Chiossi G., Di Tommaso M., Monari F., Consonni S., Strambi N., Zoccoli S. G., Seravalli V., Comerio C., Betti M., Cappello A., Vergani P., Facchinetti F., Locatelli A., Chiossi, G, Di Tommaso, M, Monari, F, Consonni, S, Strambi, N, Zoccoli, S, Seravalli, V, Comerio, C, Betti, M, Cappello, A, Vergani, P, Facchinetti, F, Locatelli, A, Chiossi G., Di Tommaso M., Monari F., Consonni S., Strambi N., Zoccoli S. G., Seravalli V., Comerio C., Betti M., Cappello A., Vergani P., Facchinetti F., and Locatelli A.

Abstract

Objective: Expectant management in patients with prelabor preterm rupture of membranes between between 340/7 and 36 6/7 weeks (late preterm pPROM or LpPROM) has been shown to decrease the burden of prematurity, when compared to immediate delivery. As the severity of prematurity depends on gestational age (GA) at PROM, and PROM to delivery interval, we first investigated how such variables affect neonatal outcomes (NO). Second, we assessed the risk of neonatal sepsis. Study design: retrospective cohort study on neonatal morbidity among singleton infants born to expectantly managed mothers with LpPROM in five hospitals affiliated with three Italian academic institutions. The primary NO was a composite of neonatal death, non-invasive (cPAP) or invasive (mechanical ventilation) respiratory support, hypoglycemia (< 44 mg/dl needing therapy), newborn sepsis, confirmed seizures, stroke, intraventricular hemorrhage (IVH), basal nuclei anomalies, cardiopulmonary resuscitation, umbilical-cord-blood arterial pH < 7.0 or base excess < -12.5, and prolonged hospitalization (≥ 5 days). Univariate analysis described differences in the population according to GA at delivery. Multivariate logistic regression was then used to investigate the effects of GA at PROM, and PROM to delivery interval on the NO. Results: 258/606 (42.6 %) women with LpPROM were expectantly managed, as they did not deliver within the first 24 h. The median latency duration was 2 (95 %CI 1−3) days, having no effect on neonatal morbidity on multivariate analysis. Multivariate analysis also showed increased risks of adverse NO among PROM at 34 (OR 2.3 95 %CI 1.03−5.1) but not at 35 weeks when compared to 36 weeks, and among women receiving antenatal corticosteroids (OR 3.6 95 %CI 1.3−9.7), while antibiotic treatment showed a non-significant protective effect (OR 0.2 95 %CI 0.04−1.02). Prevalence of neonatal sepsis was 0.8 % (2/258) Conclusion: Expectant management of LpPROM should be encouraged especially

Published
2021

23. Valacyclovir for prevention and treatment of fetal CMV infection: inclusion in the Law 648/96 list and launch of the Italian multicentre observational prospective study 'MEGAL-ITALI'

Author

Zammarchi, L., Lazzarotto, T., Di Tommaso, M., Tomasoni, L., Pasquini, L., Galli, L., Simonazzi, G., Castelli, F., Borchi, B., Campolmi, I., SARA ORNAGHI, Bartoloni, A., Andreoni, M., Pagano, I., Petraglia, S., Ramenghi, L., Clerici, P., Tavio, M., Trotta, M., Zammarchi L, Lazzarotto T, Di Tommaso M, Tomasoni L, Pasquini L, Galli L, Simonazzi G, Castelli F, Borchi B, Campolmi I, Ornaghi S, Bartoloni A, Andreoni M, Pagano I, Petraglia S, Ramenghi L, Clerici P, Tavio M, Trotta M., Zammarchi, L, Lazzarotto, T, Di Tommaso, M, Tomasoni, L, Pasquini, L, Galli, L, Simonazzi, G, Castelli, F, Borchi, B, Campolmi, I, Ornaghi, S, Bartoloni, A, Andreoni, M, Pagano, I, Petraglia, S, Ramenghi, L, Clerici, P, Tavio, M, and Trotta, M

Subjects
Valacyclovir, Citomegalovirus, pregnancy, Italy, Valacyclovir, Cytomegalovirus Infections, Infant, Newborn, Humans, Infant, Antiviral Agents, Newborn, valacyclovir, congenital, cytomegalovirus
Abstract

not available

Published
2021

28. EP17.11: Microvascular function assessed by laser speckle contrast imaging in pregnancies complicated by pre‐eclampsia and fetal growth restriction.

Author

Seravalli, V., Huri, M., Abati, I., Vallario, A., Bartolini, C., Impastato, G., Santalucia, M., and Di Tommaso, M.

Subjects
SPECKLE interference, FETAL growth retardation, SPECKLE interferometry, PREECLAMPSIA, GESTATIONAL age, ECLAMPSIA
Abstract

This article, published in the journal "Ultrasound in Obstetrics & Gynecology," examines the microvascular function in pregnancies complicated by pre-eclampsia and fetal growth restriction (FGR) compared to uncomplicated pregnancies. The study involved 25 women with pre-eclampsia and/or FGR and 25 uncomplicated pregnancies as controls. The researchers used laser speckle contrast imaging (LSCI) combined with post-occlusive reactive hyperemia (PORH) to assess microvascular function. The results showed that microvascular function was impaired in pregnancies with placental-related diseases, particularly pre-eclampsia. The authors suggest further investigation into the use of LSCI as a tool for predicting and diagnosing pre-eclampsia. [Extracted from the article]

Published
2024
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29. ZOOMICS: comparative metabolomics of red blood cells from dogs, cows, horses and donkeys during refrigerated storage for up to 42 days

Author

Miglio, A, Maslanka, M, Di Tommaso, M, Rocconi, F, Nemkov, T, Buehler, Pw, Antognoni, Mt, Spitalnik, Sl, and D’Alessandro, A.

Subjects
comparative biology, erythrocyte, hemolysis, metabolomics, comparative biology, erythrocyte, hemolysis, metabolomics
Abstract

The use of omics technologies in human transfusion medicine has improved our understanding of the red blood cell (RBC) storage lesion(s). Despite significant progress towards understanding the storage lesion(s) of human RBCs, a comparison of basal and post-storage RBC metabolism across multiple species using omics technologies has not yet been reported, and is the focus of this study.Blood was collected in a standard bag system (CPD-SAG-Mannitol) from dogs (n=8), horses, bovines, and donkeys (n=6). All bags were stored at 4°C for up to 42 days (i.e., the end of the shelf life in Italian veterinary clinics) and sampled weekly for metabolomics analyses. In addition, data comparisons to on our ongoing Zoomics project are included to compare this study's results with those of non-human primates and humans.Significant interspecies differences in RBC metabolism were observed at baseline, at the time of donation, with bovine showing significantly higher levels of metabolites in the tryptophan/kynurenine pathway; dogs showing elevated levels of high-energy compounds (especially adenosine triphosphate and S-adenosyl-methionine) and equine (donkey and horse) RBCs showing almost overlapping phenotypes, with the highest levels of free branched chain amino acids, glycolytic metabolites (including 2,3-diphosphoglycerate), higher total glutathione pools, and elevated metabolites of the folate pathway compared to the other species. Strikingly, previously described metabolic markers of the storage lesion(s) in humans followed similar trends across all species, though the rate of accumulation/depletion of metabolites in energy and redox metabolism varied by species, with equine blood showing the lowest degree of storage lesion(s).These results interrogate RBC metabolism across a range of mammalian species and improve our understanding of both human and veterinary blood storage and transfusion.

Published
2022

31. Serial cervical length measurements after the 1st episode of threatened preterm labor improve prediction of spontaneous delivery prior to 37 weeks' gestation

Author

Chiossi, G, Facchinetti, F, Vergani, P, Di Tommaso, M, Marozio, L, Acaia, B, Pignatti, L, Locatelli, A, Spitaleri, M, Benedetto, C, Zaina, B, D'Amico, R, Chiossi, G, Facchinetti, F, Vergani, P, Di Tommaso, M, Marozio, L, Acaia, B, Pignatti, L, Locatelli, A, Spitaleri, M, Benedetto, C, Zaina, B, and D'Amico, R

Subjects
threatened preterm labor, spontaneous preterm birth, cervical length
Abstract

Objective: To assess whether repeat cervical-length (CL) measurement in women discharged from hospital after their first episode of threatened preterm labor can predict their risk of spontaneous preterm birth. Methods: This was a secondary analysis of a randomized controlled trial of maintenance tocolysis, in which CL was measured on transvaginal ultrasound at the time of hospital discharge and after 2, 4, 8 and 12 weeks, in women who remained undelivered after their first episode of threatened preterm labor. After univariate analysis, multivariate logistic regression analysis was used to assess whether CL < 10 mm at the time of hospital discharge or at any follow-up evaluation could predict spontaneous delivery prior to 37 weeks of gestation. Results: Of 226 women discharged after a diagnosis of threatened preterm labor, 57 (25.2%) delivered spontaneously prior to 37 weeks' gestation. The risk of spontaneous preterm birth was higher among women with CL < 10 mm at hospital discharge compared to those with CL ≥ 10 mm (adjusted odds ratio (aOR), 3.3; 95% CI, 1.2–9.2). Moreover, spontaneous preterm delivery was more common when CL < 10 mm was detected up to 2 weeks (aOR, 2.9; 95% CI, 1.1–7.3) or up to 4 weeks (aOR, 7.3; 95% CI, 2.3–22.8) post discharge, as compared with when CL was persistently ≥ 10 mm. The association was not significant when considering CL measurements at 8 weeks, and there was insufficient information to assess the effect of measurements obtained at 12 weeks. Conclusions: Women who remain undelivered after their first episode of threatened preterm labor continue to be at high risk of spontaneous preterm birth if their CL is below 10 mm at the time of hospital discharge or at any follow-up visit up to 4 weeks later. CL measurement could be included in the antenatal care of these women in order to stratify their risk of preterm birth, rationalize resource utilization and help clinicians improve pregnancy outcome. © 2020 International Society of Ultrasound in Obstetrics and Gynecology.

Published
2021

38. PO-1137 A prospective study on Quality of life in patients treated with radiotherapy for early breast cancer

Author

Di Guglielmo, F.C., primary, Ursini, L.A., additional, Nuzzo, M., additional, Rosa, C., additional, Di Tommaso, M., additional, Trignani, M., additional, Borgia, M., additional, Allajbej, A., additional, Patani, F., additional, Di Carlo, C., additional, Porreca, A., additional, Di Nicola, M., additional, Genovesi, D., additional, and Caravatta, L., additional

Published
2021
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41. Una strategia di resilienza intelligente per il dopo coronavirus. Sulla centralità della domanda e offerta di politica industriale

Author

Di Tommaso, M. R. and Di Tommaso, M. R.

Subjects
Coronavirus, Economica, Covid19, Coronavirus, Structural Change, Industrial Policy, Resilience, Sustainability, Resilience, Sustainability, SH2_2, Coronaviru, SH1_2, Socio-culturale, SH1_5, Structural Change, Industrial Policy, Covid19
Abstract

This paper focuses on the process of structural change triggered by the covid19 shock and on industrial policy, meant as one of the possible tools able to govern this complex economic and social transformation process. With reference to a wide national and international literature, a smart resilient industrial and development strategy is defined and discussed. This strategy has two main goals: a) granting economic and social sustainability; b) offering concrete solutions to those government failures emphasised by Economics and Political Economy literature. This article highlights strengths and weaknesses of the current debate, suggesting the need of rethinking industrial policy governance, implementation and management with the aim of going beyond unproductive ideological positions and offering a contribute to theoretical issues and policy-making problems.

Published
2020

42. Tackling the Gender Gap in Mathematics with Active Learning Methodologies

Author

Di Tommaso, M. L., Contini, D., De Rosa, D., Ferrara, F., Piazzalunga, D., and Robutti, O.

Subjects
mathematics, school achievement, active learning, randomized controlled trial, gender gap, teaching methodologies, gender gap, mathematics, school achievement, primary school, active learning, teaching methodologies, randomized controlled trial, primary school
Published
2021

43. Treatment volume, dose prescription and delivery techniques for dose-intensification in Rectal Cancer: A national survey

Author

Caravatta, L., Lupattelli, M., Mantello, G., Gambacorta, Maria Antonietta, Chiloiro, Giuditta, Di Tommaso, M., Rosa, C., Gasparini, L., Morganti, Alessio Giuseppe, Picardi, V., Niespolo, R. M., Osti, M. F., Montrone, S., Simoni, N., Boso, C., Facchin, F., Deidda, M. A., Piva, C., Guida, C., Ziccarelli, L., Munoz, F., Ivaldi, G. B., Marchetti, V., Franzone, P., Spatola, C., Franco, P., Donato, V., Genovesi, D., Gambacorta M. A. (ORCID:0000-0001-5455-8737), Chiloiro G., Morganti A. G., Caravatta, L., Lupattelli, M., Mantello, G., Gambacorta, Maria Antonietta, Chiloiro, Giuditta, Di Tommaso, M., Rosa, C., Gasparini, L., Morganti, Alessio Giuseppe, Picardi, V., Niespolo, R. M., Osti, M. F., Montrone, S., Simoni, N., Boso, C., Facchin, F., Deidda, M. A., Piva, C., Guida, C., Ziccarelli, L., Munoz, F., Ivaldi, G. B., Marchetti, V., Franzone, P., Spatola, C., Franco, P., Donato, V., Genovesi, D., Gambacorta M. A. (ORCID:0000-0001-5455-8737), Chiloiro G., and Morganti A. G.

Abstract

Background/Aim: The aim of the study was to investigate boost volume definition, doses, and delivery techniques for rectal cancer dose intensification. Patients and Methods: An online survey was made on 25 items (characteristics, simulation, imaging, volumes, doses, planning and treatment). Results: Thirty-eight radiation oncologists joined the study. Twenty-one delivered long-course radiotherapy with dose intensification. Boost volume was delineated on diagnostic magnetic resonance imaging (MRI) in 18 centres (85.7%), and computed tomography (CT) and/or positron emission tomography-CT in 9 (42.8%); 16 centres (76.2%) performed co-registration with CT-simulation. Boost dose was delivered on gross tumor volume in 10 centres (47.6%) and on clinical target volume in 11 (52.4%). The most common total dose was 54-55 Gy (71.4%), with moderate hypofractionation (85.7%). Intensity-modulated radiotherapy (IMRT) was used in all centres, with simultaneous integrated boost in 17 (80.8%) and image-guidance in 18 (85.7%). Conclusion: A high quality of treatment using dose escalation can be inferred by widespread multidisciplinary discussion, MRI-based treatment volume delineation, and radiation delivery relying on IMRT with accurate image-guided radiation therapy protocols.

Published
2021

48. PD-0656: A contouring atlas on MRI of emerging pelvic female organs at risk for daily practice radiotherapy

Author

Allajbej, A., primary, Patani, F., additional, Gasparini, L., additional, Di Guglielmo, F.C., additional, Bonfiglio, C., additional, Fasciolo, D., additional, Rosa, C., additional, Trignani, M., additional, Vinciguerra, A., additional, Caravatta, L., additional, Di Tommaso, M., additional, Cianci, R., additional, Basilico, R., additional, Augurio, A., additional, and Genovesi, D., additional

Published
2020
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