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1. Health planning for the future: comparative risk assessment of five major lifestyle risk factors: evidence from the Wirral, UK

Author: Möller, H., Dherani, M., Harwood, C., Kinsella, T., and Pope, D.
Published: 2012

2. Ramadan and eye-drops: perspective of Muslims in the UK

Author: Kumar, N, Dherani, M, and Jivan, S
Published: 2009
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3. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Author: Shi, T, McAllister, DA, O'Brien, KL, Simoes, EAF, Madhi, SA, Gessner, BD, Polack, FP, Balsells, E, Acacio, S, Aguayo, C, Alassani, I, Ali, A, Antonio, M, Awasthi, S, Awori, JO, Azziz-Baumgartner, E, Baggett, HC, Baillie, VL, Balmaseda, A, Barahona, A, Basnet, S, Bassat, Q, Basualdo, W, Bigogo, G, Bont, L, Breiman, RF, Brooks, WA, Broor, S, Bruce, N, Bruden, D, Buchy, P, Campbell, S, Carosone-Link, P, Chadha, M, Chipeta, J, Chou, M, Clara, W, Cohen, C, de Cuellar, E, Dang, DA, Dash-yandag, B, Deloria-Knoll, M, Dherani, M, Eap, T, Ebruke, BE, Echavarria, M, de Freitas Lázaro Emediato, CC, Fasce, RA, Feikin, DR, Feng, L, Gentile, A, Gordon, A, Goswami, D, Goyet, S, Groome, M, Halasa, N, Hirve, S, Homaira, N, Howie, SRC, Jara, J, Jroundi, I, Kartasasmita, CB, Khuri-Bulos, N, Kotloff, KL, Krishnan, A, Libster, R, Lopez, O, Lucero, MG, Lucion, F, Lupisan, SP, Marcone, DN, McCracken, JP, Mejia, M, Moisi, JC, Montgomery, JM, Moore, DP, Moraleda, C, Moyes, J, Munywoki, P, Mutyara, K, Nicol, MP, Nokes, DJ, Nymadawa, P, da Costa Oliveira, MT, Oshitani, H, Pandey, N, Paranhos-Baccalà, G, Phillips, LN, Picot, VS, Rahman, M, Rakoto-Andrianarivelo, M, Rasmussen, ZA, Rath, BA, Robinson, A, Romero, C, Russomando, G, Salimi, V, Sawatwong, P, Scheltema, N, Schweiger, B, Shi, T, McAllister, DA, O'Brien, KL, Simoes, EAF, Madhi, SA, Gessner, BD, Polack, FP, Balsells, E, Acacio, S, Aguayo, C, Alassani, I, Ali, A, Antonio, M, Awasthi, S, Awori, JO, Azziz-Baumgartner, E, Baggett, HC, Baillie, VL, Balmaseda, A, Barahona, A, Basnet, S, Bassat, Q, Basualdo, W, Bigogo, G, Bont, L, Breiman, RF, Brooks, WA, Broor, S, Bruce, N, Bruden, D, Buchy, P, Campbell, S, Carosone-Link, P, Chadha, M, Chipeta, J, Chou, M, Clara, W, Cohen, C, de Cuellar, E, Dang, DA, Dash-yandag, B, Deloria-Knoll, M, Dherani, M, Eap, T, Ebruke, BE, Echavarria, M, de Freitas Lázaro Emediato, CC, Fasce, RA, Feikin, DR, Feng, L, Gentile, A, Gordon, A, Goswami, D, Goyet, S, Groome, M, Halasa, N, Hirve, S, Homaira, N, Howie, SRC, Jara, J, Jroundi, I, Kartasasmita, CB, Khuri-Bulos, N, Kotloff, KL, Krishnan, A, Libster, R, Lopez, O, Lucero, MG, Lucion, F, Lupisan, SP, Marcone, DN, McCracken, JP, Mejia, M, Moisi, JC, Montgomery, JM, Moore, DP, Moraleda, C, Moyes, J, Munywoki, P, Mutyara, K, Nicol, MP, Nokes, DJ, Nymadawa, P, da Costa Oliveira, MT, Oshitani, H, Pandey, N, Paranhos-Baccalà, G, Phillips, LN, Picot, VS, Rahman, M, Rakoto-Andrianarivelo, M, Rasmussen, ZA, Rath, BA, Robinson, A, Romero, C, Russomando, G, Salimi, V, Sawatwong, P, Scheltema, N, and Schweiger, B
Abstract: Background We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on RSV has yielded substantial new data from developing countries. With a considerably expanded dataset from a large international collaboration, we aimed to estimate the global incidence, hospital admission rate, and mortality from RSV-ALRI episodes in young children in 2015. Methods We estimated the incidence and hospital admission rate of RSV-associated ALRI (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions from a systematic review of studies published between Jan 1, 1995, and Dec 31, 2016, and unpublished data from 76 high quality population-based studies. We estimated the RSV-ALRI incidence for 132 developing countries using a risk factor-based model and 2015 population estimates. We estimated the in-hospital RSV-ALRI mortality by combining in-hospital case fatality ratios with hospital admission estimates from hospital-based (published and unpublished) studies. We also estimated overall RSV-ALRI mortality by identifying studies reporting monthly data for ALRI mortality in the community and RSV activity. Findings We estimated that globally in 2015, 33·1 million (uncertainty range [UR] 21·6–50·3) episodes of RSV-ALRI, resulted in about 3·2 million (2·7–3·8) hospital admissions, and 59 600 (48 000–74 500) in-hospital deaths in children younger than 5 years. In children younger than 6 months, 1·4 million (UR 1·2–1·7) hospital admissions, and 27 300 (UR 20 700–36 200) in-hospital deaths were due to RSV-ALRI. We also estimated that the overall RSV-ALRI mortality could be as high as 118 200 (UR 94 600–149 400). Incidence and mortality varied substantially from year to year in any given population. Interpretation Globally, RSV is a com
Published: 2017

4. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: A systematic analysis for the Global Burden of Disease Study 2016

Author: Wang, H, Abajobir, A, Abate, K, Abbafati, C, Abbas, K, Abd-Allah, F, Abera, S, Abraha, H, Abu-Raddad, L, Abu-Rmeileh, N, Adedeji, I, Adedoyin, R, Adetifa, I, Adetokunboh, O, Afshin, A, Aggarwal, R, Agrawal, A, Agrawal, S, Ahmad Kiadaliri, A, Ahmed, M, Aichour, A, Aichour, I, Aichour, M, Aiyar, S, Akanda, A, Akinyemiju, T, Akseer, N, Al-Eyadhy, A, Al Lami, F, Alabed, S, Alahdab, F, Al-Aly, Z, Alam, K, Alam, N, Alasfoor, D, Aldridge, R, Alene, K, Alhabib, S, Ali, R, Alizadeh-Navaei, R, Aljunid, S, Alkaabi, J, Alkerwi, A, Alla, F, Allam, S, Allebeck, P, Al-Raddadi, R, Alsharif, U, Altirkawi, K, Martin, E, Alvis-Guzman, N, Amare, A, Ameh, E, Amini, E, Ammar, W, Amoako, Y, Anber, N, Andrei, C, Androudi, S, Ansari, H, Ansha, M, Antonio, C, Anwari, P, Ärnlöv, J, Arora, M, Artaman, A, Aryal, K, Asayesh, H, Asgedom, S, Asghar, R, Assadi, R, Atey, T, Atre, S, Avila-Burgos, L, Avokpaho, E, Awasthi, A, Ayala Quintanilla, B, Babalola, T, Bacha, U, Badawi, A, Balakrishnan, K, Balalla, S, Barac, A, Barber, R, Barboza, M, Barker-Collo, S, Bärnighausen, T, Barquera, S, Barregard, L, Barrero, L, Baune, B, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Béjot, Y, Bekele, B, Bell, M, Bello, A, Bennett, D, Bennett, J, Bensenor, I, Benson, J, Berhane, A, Berhe, D, Bernabé, E, Beuran, M, Beyene, A, Bhala, N, Bhansali, A, Bhaumik, S, Bhutta, Z, Bikbov, B, Birungi, C, Biryukov, S, Bisanzio, D, Bizuayehu, H, Bjerregaard, P, Blosser, C, Boneya, D, Boufous, S, Bourne, R, Brazinova, A, Breitborde, N, Brenner, H, Brugha, T, Bukhman, G, Bulto, L, Bumgarner, B, Burch, M, Butt, Z, Cahill, L, Cahuana-Hurtado, L, Campos-Nonato, I, Car, J, Car, M, Cárdenas, R, Carpenter, D, Carrero, J, Carter, A, Castañeda-Orjuela, C, Castillo Rivas, J, Castro, F, Castro, R, Catalá-López, F, Chen, H, Chiang, P, Chibalabala, M, Chisumpa, V, Chitheer, A, Choi, J, Christensen, H, Christopher, D, Ciobanu, L, Cirillo, M, Cohen, A, Colquhoun, S, Coresh, J, Criqui, M, Cromwell, E, Crump, J, Dandona, L, Dandona, R, Dargan, P, Das Neves, J, Davey, G, Davitoiu, D, Davletov, K, De Courten, B, De Leo, D, Degenhardt, L, Deiparine, S, Dellavalle, R, Deribe, K, Deribew, A, Des Jarlais, D, Dey, S, Dharmaratne, S, Dherani, M, Diaz-Torné, C, Ding, E, Dixit, P, Djalalinia, S, Do, H, Doku, D, Donnelly, C, Dos Santos, K, Douwes-Schultz, D, Driscoll, T, Duan, L, Dubey, M, Duncan, B, Dwivedi, L, Ebrahimi, H, El Bcheraoui, C, Ellingsen, C, Enayati, A, Endries, A, Ermakov, S, Eshetie, S, Eshrati, B, Eskandarieh, S, Esteghamati, A, Estep, K, Fanuel, F, Faro, A, Farvid, M, Farzadfar, F, Feigin, V, Fereshtehnejad, S, Fernandes, J, Feyissa, T, Filip, I, Fischer, F, Foigt, N, Foreman, K, Frank, T, Franklin, R, Fraser, M, Friedman, J, Frostad, J, Fullman, N, Fürst, T, Furtado, J, Futran, N, Gakidou, E, Gambashidze, K, Gamkrelidze, A, Gankpé, F, Garcia-Basteiro, A, Gebregergs, G, Gebrehiwot, T, Gebrekidan, K, Gebremichael, M, Gelaye, A, Geleijnse, J, Gemechu, B, Gemechu, K, Genova-Maleras, R, Gesesew, H, Gething, P, Gibney, K, Gill, P, Gillum, R, Giref, A, Girma, B, Giussani, G, Goenka, S, Gomez, B, Gona, P, Gopalani, S, Goulart, A, Graetz, N, Gugnani, H, Gupta, P, Gupta, R, Gupta, T, Gupta, V, Haagsma, J, Hafezi-Nejad, N, Haghparast Bidgoli, H, Hakuzimana, A, Halasa, Y, Hamadeh, R, Hambisa, M, Hamidi, S, Hammami, M, Hancock, J, Handal, A, Hankey, G, Hao, Y, Harb, H, Hareri, H, Harikrishnan, S, Haro, J, Hassanvand, M, Havmoeller, R, Hay, R, Hay, S, He, F, Heredia-Pi, I, Herteliu, C, Hilawe, E, Hoek, H, Horita, N, Hosgood, H, Hostiuc, S, Hotez, P, Hoy, D, Hsairi, M, Htet, A, Hu, G, Huang, H, Huang, J, Iburg, K, Igumbor, E, Ileanu, B, Inoue, M, Irenso, A, Irvine, C, Islam, N, Jacobsen, K, Jaenisch, T, Jahanmehr, N, Jakovljevic, M, Javanbakht, M, Jayatilleke, A, Jeemon, P, Jensen, P, Jha, V, Jin, Y, John, D, John, O, Johnson, S, Jonas, J, Jürisson, M, Kabir, Z, Kadel, R, Kahsay, A, Kalkonde, Y, Kamal, R, Kan, H, Karch, A, Karema, C, Karimi, S, Karthikeyan, G, Kasaeian, A, Kassaw, N, Kassebaum, N, Kastor, A, Katikireddi, S, Kaul, A, Kawakami, N, Kazanjan, K, Keiyoro, P, Kelbore, S, Kemp, A, Kengne, A, Keren, A, Kereselidze, M, Kesavachandran, C, Ketema, E, Khader, Y, Khalil, I, Khan, E, Khan, G, Khang, Y, Khera, S, Khoja, A, Khosravi, M, Kibret, G, Kieling, C, Kim, C, Kim, D, Kim, P, Kim, S, Kim, Y, Kimokoti, R, Kinfu, Y, Kishawi, S, Kissimova-Skarbek, K, Kissoon, N, Kivimaki, M, Knudsen, A, Kokubo, Y, Kopec, J, Kosen, S, Koul, P, Koyanagi, A, Kravchenko, M, Krohn, K, Kuate Defo, B, Kucuk Bicer, B, Kuipers, E, Kulikoff, X, Kulkarni, V, Kumar, G, Kumar, P, Kumsa, F, Kutz, M, Lachat, C, Lagat, A, Lager, A, Lal, D, Lalloo, R, Lambert, N, Lan, Q, Van Lansingh, C, Larson, H, Larsson, A, Laryea, D, Lavados, P, Laxmaiah, A, Lee, P, Leigh, J, Leung, J, Leung, R, Levi, M, Li, Y, Liao, Y, Liben, M, Lim, S, Linn, S, Lipshultz, S, Liu, S, Lodha, R, Logroscino, G, Lorch, S, Lorkowski, S, Lotufo, P, Lozano, R, Lunevicius, R, Lyons, R, Ma, S, Macarayan, E, Machado, I, Mackay, M, Magdy Abd El Razek, M, Magis-Rodriguez, C, Mahdavi, M, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Malhotra, R, Malta, D, Mantovani, L, Manyazewal, T, Mapoma, C, Marczak, L, Marks, G, Martinez-Raga, J, Martins-Melo, F, Massano, J, Maulik, P, Mayosi, B, Mazidi, M, Mcalinden, C, Mcgarvey, S, Mcgrath, J, Mckee, M, Mehata, S, Mehndiratta, M, Mehta, K, Meier, T, Mekonnen, T, Meles, K, Memiah, P, Memish, Z, Mendoza, W, Mengesha, M, Mengistie, M, Mengistu, D, Menon, G, Menota, B, Mensah, G, Meretoja, A, Meretoja, T, Mezgebe, H, Micha, R, Mikesell, J, Miller, T, Mills, E, Minnig, S, Mirarefin, M, Mirrakhimov, E, Misganaw, A, Mishra, S, Mohammad, K, Mohammadi, A, Mohammed, K, Mohammed, S, Mohan, M, Mohanty, S, Mokdad, A, Molla Assaye, A, Mollenkopf, S, Molokhia, M, Monasta, L, Montañez Hernandez, J, Montico, M, Mooney, M, Moore, A, Moradi-Lakeh, M, Moraga, P, Morawska, L, Moreno Velasquez, I, Mori, R, Morrison, S, Mruts, K, Mueller, U, Mullany, E, Muller, K, Murthy, G, Murthy, S, Musa, K, Nachega, J, Nagata, C, Nagel, G, Naghavi, M, Naidoo, K, Nanda, L, Nangia, V, Nascimento, B, Natarajan, G, Negoi, I, Nguyen, C, Nguyen, G, Nguyen, Q, Nguyen, T, Ningrum, D, Nisar, M, Nomura, M, Nong, V, Norheim, O, Norrving, B, Noubiap, J, Nyakarahuka, L, Obermeyer, C, O'Donnell, M, Ogbo, F, Oh, I, Okoro, A, Oladimeji, O, Olagunju, A, Olusanya, B, Olusanya, J, Oren, E, Ortiz, A, Osgood-Zimmerman, A, Ota, E, Owolabi, M, Oyekale, A, Mahesh, P, Pacella, R, Pakhale, S, Pana, A, Panda, B, Panda-Jonas, S, Park, E, Parsaeian, M, Patel, T, Patten, S, Patton, G, Paudel, D, Pereira, D, Perez-Padilla, R, Perez-Ruiz, F, Perico, N, Pervaiz, A, Pesudovs, K, Peterson, C, Petri, W, Petzold, M, Phillips, M, Piel, F, Pigott, D, Pishgar, F, Plass, D, Polinder, S, Popova, S, Postma, M, Poulton, R, Pourmalek, F, Prasad, N, Purwar, M, Qorbani, M, Rabiee, R, Radfar, A, Rafay, A, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rahman, S, Rai, R, Rajsic, S, Ram, U, Rana, S, Ranabhat, C, Rao, P, Rawaf, S, Ray, S, Rego, M, Rehm, J, Reiner, R, Remuzzi, G, Renzaho, A, Resnikoff, S, Rezaei, S, Rezai, M, Ribeiro, A, Rokni, M, Ronfani, L, Roshandel, G, Roth, G, Rothenbacher, D, Roy, A, Rubagotti, E, Ruhago, G, Saadat, S, Sabde, Y, Sachdev, P, Sadat, N, Safdarian, M, Safi, S, Safiri, S, Sagar, R, Sahathevan, R, Sahebkar, A, Sahraian, M, Salama, J, Salamati, P, Salomon, J, Salvi, S, Samy, A, Sanabria, J, Sanchez-Niño, M, Santos, I, Santric Milicevic, M, Sarmiento-Suarez, R, Sartorius, B, Satpathy, M, Sawhney, M, Saxena, S, Saylan, M, Schmidt, M, Schneider, I, Schutte, A, Schwebel, D, Schwendicke, F, Seedat, S, Seid, A, Sepanlou, S, Servan-Mori, E, Shackelford, K, Shaheen, A, Shahraz, S, Shaikh, M, Shamsipour, M, Shamsizadeh, M, Islam, S, Sharma, J, Sharma, R, She, J, Shen, J, Shetty, B, Shi, P, Shibuya, K, Shigematsu, M, Shiri, R, Shiue, I, Shrime, M, Sigfusdottir, I, Silberberg, D, Silpakit, N, Silva, D, Silva, J, Silveira, D, Sindi, S, Singh, A, Singh, J, Singh, P, Singh, V, Sinha, D, Skiadaresi, E, Sligar, A, Smith, D, Sobaih, B, Sobngwi, E, Soneji, S, Soriano, J, Sreeramareddy, C, Srinivasan, V, Stathopoulou, V, Steel, N, Stein, D, Steiner, C, Stöckl, H, Stokes, M, Strong, M, Sufiyan, M, Suliankatchi, R, Sunguya, B, Sur, P, Swaminathan, S, Sykes, B, Szoeke, C, Tabarés-Seisdedos, R, Tadakamadla, S, Tadese, F, Tandon, N, Tanne, D, Tarajia, M, Tavakkoli, M, Taveira, N, Tehrani-Banihashemi, A, Tekelab, T, Tekle, D, Temam Shifa, G, Temsah, M, Terkawi, A, Tesema, C, Tesssema, B, Theis, A, Thomas, N, Thompson, A, Thomson, A, Thrift, A, Tiruye, T, Tobe-Gai, R, Tonelli, M, Topor-Madry, R, Topouzis, F, Tortajada, M, Tran, B, Truelsen, T, Trujillo, U, Tsilimparis, N, Tuem, K, Tuzcu, E, Tyrovolas, S, Ukwaja, K, Undurraga, E, Uthman, O, Uzochukwu, B, Van Boven, J, Varakin, Y, Varughese, S, Vasankari, T, Vasconcelos, A, Venketasubramanian, N, Vidavalur, R, Violante, F, Vishnu, A, Vladimirov, S, Vlassov, V, Vollset, S, Vos, T, Waid, J, Wakayo, T, Wang, Y, Weichenthal, S, Weiderpass, E, Weintraub, R, Werdecker, A, Wesana, J, Wijeratne, T, Wilkinson, J, Wiysonge, C, Woldeyes, B, Wolfe, C, Workicho, A, Workie, S, Xavier, D, Xu, G, Yaghoubi, M, Yakob, B, Yalew, A, Yan, L, Yano, Y, Yaseri, M, Ye, P, Yimam, H, Yip, P, Yirsaw, B, Yonemoto, N, Yoon, S, Yotebieng, M, Younis, M, Zaidi, Z, El Sayed Zaki, M, Zeeb, H, Zenebe, Z, Zerfu, T, Zhang, A, Zhang, X, Zodpey, S, Zuhlke, L, Lopez, A, Murray, C, Abajobir, AA, Abate, KH, Abbas, KM, Abera, SF, Abraha, HN, Abu-Raddad, LJ, Abu-Rmeileh, NME, Adedeji, IA, Adedoyin, RA, Adetifa, IMO, Ahmed, MB, Aichour, Amani N, Aichour, MTE, Akanda, AS, Akinyemiju, TF, Al Lami, FH, Aldridge, RW, Alene, KA, Aljunid, SM, Alkaabi, JM, Allam, SD, Altirkawi, KA, Martin, EA, Amare, AT, Ameh, EA, Amoako, YA, Andrei, CL, Ansha, MG, Antonio, CAT, Aryal, KK, Asgedom, SW, Asghar, RJ, Atey, TM, Atre, SR, Avokpaho, EFGA, Ayala Quintanilla, BP, Babalola, TK, Barber, RM, Barboza, MA, Barker-Collo, SL, Barrero, LH, Baune, BT, Bekele, BB, Bell, ML, Bello, AK, Bennett, DA, Bennett, JR, Bensenor, IM, Berhe, DF, Beyene, AS, Bhutta, ZA, Bizuayehu, HM, Blosser, CD, Boneya, DJ, Bourne, RRA, Breitborde, NJK, Brugha, TS, Bulto, LNB, Bumgarner, BR, Butt, ZA, Cahill, LE, Campos-Nonato, IR, Carpenter, DO, Carrero, JJ, Castañeda-Orjuela, CA, Castro, FF, Castro, RE, Chiang, Peggy PC, Chisumpa, VH, Chitheer, AA, Choi, JYJ, Christopher, DJ, Ciobanu, LG, Cohen, AJ, Colquhoun, SM, Criqui, MH, Cromwell, EA, Crump, JA, Dargan, PI, Davitoiu, DV, Dellavalle, RP, Des Jarlais, DC, Dharmaratne, SD, Dherani, MK, Ding, EL, Do, HP, Doku, DT, Donnelly, CA, Dos Santos, KPB, Driscoll, TR, Duncan, BB, Dwivedi, LK, Ellingsen, CL, Endries, AY, Ermakov, SP, Fanuel, FBB, Farvid, MS, Feigin, VL, Fereshtehnejad, SM, Fernandes, JG, Fernandes, JC, Feyissa, TR, Foreman, KJ, Franklin, RC, Frostad, JJ, Furtado, JM, Futran, ND, Gankpé, FG, Garcia-Basteiro, AL, Gebregergs, GB, Gebrehiwot, TT, Gebrekidan, KG, Gebremichael, MW, Gelaye, AA, Geleijnse, JM, Gemechu, BL, Gemechu, KS, Gesesew, HA, Gething, PW, Gibney, KB, Gill, PS, Gillum, RF, Giref, AZ, Girma, BW, Gopalani, SV, Goulart, AC, Gugnani, HC, Gupta, PC, Haagsma, JA, Haghparast Bidgoli, Hassan, Hakuzimana, Alex, Halasa, Yara A., Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Hareri, Habtamu Abera, Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Roderick J., Hay, Simon I., He, Fei, Heredia-Pi, Ileana Beatriz, Herteliu, Claudiu, Hilawe, Esayas Haregot, Hoek, Hans W., Horita, Nobuyuki, Hosgood, H. Dean, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian G., Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, Hsiang, Huang, John J., Iburg, Kim Moesgaard, Igumbor, Ehimario Uche, Ileanu, Bogdan Vasile, Inoue, Manami, Irenso, Asnake Ararsa, Irvine, Caleb M. S., Islam, Nazrul, Jacobsen, Kathryn H., Jaenisch, Thomas, Jahanmehr, Nader, Jakovljevic, Mihajlo B., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jensen, Paul N., Jha, Vivekanand, Jin, Ye, John, Denny, John, Oommen, Johnson, Sarah Charlotte, Jonas, Jost B., Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, André, Karema, Corine Kakizi, Karimi, Seyed M., Karthikeyan, Ganesan, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J., Kastor, Anshul, Katikireddi, Srinivasa Vittal, Kaul, Anil, Kawakami, Norito, Kazanjan, Konstantin, Keiyoro, Peter Njenga, Kelbore, Sefonias Getachew, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kereselidze, Maia, Kesavachandran, Chandrasekharan Nair, Ketema, Ezra Belay, Khader, Yousef Saleh, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khera, Sahil, Khoja, Abdullah Tawfih Abdullah, Khosravi, Mohammad Hossein, Kibret, 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Haghparast Bidgoli, Hassan, Hakuzimana, Alex, Halasa, Yara A., Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Hareri, Habtamu Abera, Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Roderick J., Hay, Simon I., He, Fei, Heredia-Pi, Ileana Beatriz, Herteliu, Claudiu, Hilawe, Esayas Haregot, Hoek, Hans W., Horita, Nobuyuki, Hosgood, H. Dean, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian G., Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, Hsiang, Huang, John J., Iburg, Kim Moesgaard, Igumbor, Ehimario Uche, Ileanu, Bogdan Vasile, Inoue, Manami, Irenso, Asnake Ararsa, Irvine, Caleb M. S., Islam, Nazrul, Jacobsen, Kathryn H., Jaenisch, Thomas, Jahanmehr, Nader, Jakovljevic, Mihajlo B., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jensen, Paul N., Jha, Vivekanand, Jin, Ye, John, Denny, John, Oommen, Johnson, Sarah Charlotte, Jonas, Jost B., Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, André, Karema, Corine Kakizi, Karimi, Seyed M., Karthikeyan, Ganesan, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J., Kastor, Anshul, Katikireddi, Srinivasa Vittal, Kaul, Anil, Kawakami, Norito, Kazanjan, Konstantin, Keiyoro, Peter Njenga, Kelbore, Sefonias Getachew, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kereselidze, Maia, Kesavachandran, Chandrasekharan Nair, Ketema, Ezra Belay, Khader, Yousef Saleh, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khera, Sahil, Khoja, Abdullah Tawfih Abdullah, Khosravi, Mohammad Hossein, Kibret, Getiye Dejenu, Kieling, Christian, Kim, Cho-Il, Kim, Daniel, Kim, Pauline, Kim, Sungroul, Kim, Yun Jin, Kimokoti, Ruth W., Kinfu, Yohannes, Kishawi, Sami, Kissimova-Skarbek, Katarzyna A., Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kopec, JA, Koul, PA, Krohn, KJ, Kuipers, EJ, Kulikoff, XR, Kulkarni, VS, Kumar, GA, Kumsa, FA, Lagat, AK, Lager, ACJ, Lal, DK, Larson, HJ, Laryea, DO, Lavados, PM, Lee, PH, Liben, ML, Lim, SS, Lipshultz, SE, Lorch, SA, Lotufo, PA, Lyons, RA, Macarayan, ERK, Machado, IE, Mackay, MT, Malta, DC, Mantovani, LG, Mapoma, CC, Marczak, LB, Marks, GB, Martins-Melo, FR, Maulik, PK, Mayosi, BM, McAlinden, C, McGarvey, ST, McGrath, JJ, McKee, M, Mehndiratta, MM, Mehta, KM, Mekonnen, TC, Meles, KG, Memish, ZA, Mengesha, MM, Mengistie, MA, Mengistu, DT, Menon, GR, Menota, BG, Mensah, GA, Meretoja, TJ, Mezgebe, HB, Miller, TR, Mills, EJ, Mirrakhimov, EM, Mishra, SR, Mohammad, KA, Mohammed, KE, Mohan, MBV, Mohanty, SK, Mokdad, AH, Mollenkopf, SK, Montañez Hernandez, JC, Mooney, MD, Moore, AR, Morrison, SD, Mruts, KB, Mueller, UO, Murthy, GVS, Musa, KI, Nachega, JB, Naidoo, KS, Nascimento, BR, Nguyen, CT, Nguyen, QL, Nguyen, TH, Ningrum, DNA, Nisar, MI, Nong, VM, Norheim, OF, Noubiap, JJN, Obermeyer, CM, O'Donnell, MJ, Ogbo, FA, Oh, IH, Olagunju, AT, Olusanya, BO, Olusanya, JO, Owolabi, MO, Oyekale, AS, Mahesh, PA, Pacella, RE, Panda, BK, Park, EK, Patten, SB, Patton, GC, Pereira, DM, Peterson, CB, Petri, WA, Phillips, MR, Piel, FB, Pigott, DM, Postma, MJ, Poulton, RG, Rabiee, RHS, Rahman, MHU, Rahman, SU, Rai, RK, Rana, SM, Ranabhat, CL, Rao, PV, Rego, MAS, Reiner, RC, Renzaho, AMNN, Rezai, MS, Ribeiro, AL, Rokni, MB, Roth, GA, Ruhago, GM, Sabde, YD, Sachdev, PS, Sahraian, MA, Salomon, JA, Salvi, SS, Samy, AM, Sanabria, JR, Sanchez-Niño, MD, Santos, IS, Santric Milicevic, MM, Saylan, MI, Schmidt, MI, Schneider, IJC, Schutte, AE, Schwebel, DC, Seid, AM, Sepanlou, SG, Servan-Mori, EE, Shackelford, KA, Shaikh, MA, Islam, SMS, Shetty, BP, Shrime, MG, Sigfusdottir, ID, Silberberg, DH, Silva, DAS, Silva, JP, Silveira, DGA, Singh, JA, Singh, PK, Sinha, DN, Smith, DL, Sobaih, BHA, Soriano, JB, Sreeramareddy, CT, Stein, DJ, Stokes, MA, Sufiyan, Muawiyyah B, Suliankatchi, Rizwan A, Sunguya, BF, Sur, PJ, Sykes, BL, Szoeke, CEI, Tadakamadla, SK, Tekle, Dejen Y, Temsah, MH, Terkawi, AS, Tesema, CL, Thompson, AH, Thomson, AJ, Thrift, AG, Tiruye, TY, Tran, BX, Tuem, KB, Tuzcu, EM, Ukwaja, KN, Undurraga, EA, Uthman, OA, Uzochukwu, BSC, Van Boven, JFM, Varakin, YY, Vasconcelos, AMN, Violante, FS, Vladimirov, SK, Vlassov, VV, Vollset, SE, Waid, JL, Wang, YP, Weintraub, RG, Wilkinson, JD, Wiysonge, CS, Woldeyes, BG, Wolfe, CDA, Workie, SB, Yalew, AZ, Yan, LL, Yimam, HH, Yirsaw, BD, Yoon, SJ, Younis, MZ, Zenebe, ZM, Zerfu, TA, Zhang, AL, Zuhlke, LJ, Lopez, AD, and Murray, CJL
Abstract: Background: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. Methods: We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to
Published: 2017

5. A cost effectiveness analysis of salt reduction policies to reduce coronary heart disease in four Eastern Mediterranean countries

Author: Mason, Helen, Shoaibi, Azza, Ghandour, Rula, O'Flaherty, Martin, Capewell, Simon, Khatib, Rana, Jabr, Samer, Unal, Belgin, Sozmen, Kaan, Arfa, Chokri, Aissi, Wafa, Ben Romdhane, Habiba, Fouad, Fouad, Al-Ali, Radwan, Husseini, Abdullatif, Critchley, J., Ahmad, B., Phillimore, P., Zaman, S., Dherani, M., Vartjes, I., Bennett, K., Altun, D., Arik, H., Aslan, O., Demiral, Y., Doganay, S., Ergor, G., Gerceklioglu, G., Kilic, B., Saatli, G., Simsek, H., Satman, I., Gogen, S., Kalaca, S., Elias, M., Rastam, S., Soulaiman, N., Moukeh, G., Maziak, W., Abou Mayaleh, M., Abu-Rmeileh, N., Jaber, S., Khatib, R., Mikki, N., Abu-Kteish, H., Allani, R., Beltaifa, L., Ben Mansour, N., Lassoued, O., Saidi, O., Tlili, F., Achour, N., Ben Salah, N., Collins, M., Roglic, G., Fadhil, I., and Unwin, N.
Subjects: Palestine, Policy Models, economic evaluation, food industry, Turkey, Non-Clinical Medicine, health promotion, Epidemiology, Economics, Cost-Benefit Analysis, Economic Models, Coronary Disease, Coronary Artery Disease, Political Aspects of Health, Cardiovascular, Global Health, Social and Behavioral Sciences, Turkey (republic), Cost Effectiveness, Environmental protection, Health care, Medicine, Socioeconomics, health care economics and organizations, 2. Zero hunger, Multidisciplinary, Cost–benefit analysis, 1. No poverty, blood pressure regulation, health care cost, Cost-effectiveness analysis, salt intake, 3. Good health, Health Education and Awareness, health care policy, Quality-Adjusted Life Years, Public Health, Research Article, Operations Research, Tunisia, Clinical Research Design, Science, Political Science, Cost-Effectiveness Analysis, Public policy, Public Policy, Health Promotion, Syrian Arab Republic, Middle East, Health Economics, food composition, food processing, health education, Humans, Salt intake, Sodium Chloride, Dietary, sodium restriction, Cardiovascular Disease Epidemiology, cost control, Nutrition, Health economics, Health Care Policy, Syria, business.industry, cost effectiveness analysis, Modeling, Health Risk Analysis, ischemic heart disease, Quality-adjusted life year, Economic evaluation, Preventive Medicine, business, food packaging
Abstract: Background: Coronary Heart Disease (CHD) is rising in middle income countries. Population based strategies to reduce specific CHD risk factors have an important role to play in reducing overall CHD mortality. Reducing dietary salt consumption is a potentially cost-effective way to reduce CHD events. This paper presents an economic evaluation of population based salt reduction policies in Tunisia, Syria, Palestine and Turkey. Methods and Findings: Three policies to reduce dietary salt intake were evaluated: a health promotion campaign, labelling of food packaging and mandatory reformulation of salt content in processed food. These were evaluated separately and in combination. Estimates of the effectiveness of salt reduction on blood pressure were based on a literature review. The reduction in mortality was estimated using the IMPACT CHD model specific to that country. Cumulative population health effects were quantified as life years gained (LYG) over a 10 year time frame. The costs of each policy were estimated using evidence from comparable policies and expert opinion including public sector costs and costs to the food industry. Health care costs associated with CHDs were estimated using standardized unit costs. The total cost of implementing each policy was compared against the current baseline (no policy). All costs were calculated using 2010 PPP exchange rates. In all four countries most policies were cost saving compared with the baseline. The combination of all three policies (reducing salt consumption by 30%) resulted in estimated cost savings of $235,000,000 and 6455 LYG in Tunisia; $39,000,000 and 31674 LYG in Syria; $6,000,000 and 2682 LYG in Palestine and $1,3000,000,000 and 378439 LYG in Turkey. Conclusion: Decreasing dietary salt intake will reduce coronary heart disease deaths in the four countries. A comprehensive strategy of health education and food industry actions to label and reduce salt content would save both money and lives. European Community' Seventh Framework Programme (FP7/2007-2013) under grant agreement n223075 the MedCHAMPS project. Scopus
Published: 2014

6. Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, south Asia, and Latin America for 2012: A systematic review and meta-analysis

Author: Seale, AC, Blencowe, H, Manu, AA, Nair, H, Bahl, R, Qazi, SA, Zaidi, AK, Berkley, JA, Cousens, SN, Lawn, JE, Agustian, D, Althabe, F, Azziz-Baumgartner, E, Baqui, AH, Bausch, DG, Belizan, JM, Qar Bhutta, Z, Black, RE, Broor, S, Bruce, N, Buekens, P, Campbell, H, Carlo, WA, Chomba, E, Costello, A, Derman, RJ, Dherani, M, El-Arifeen, S, Engmann, C, Esamai, F, Ganatra, H, Garcés, A, Gessner, BD, Gill, C, Goldenberg, RL, Goudar, SS, Hambidge, KM, Hamer, DH, Hansen, NI, Hibberd, PL, Khanal, S, Kirkwood, B, Kosgei, P, Koso-Thomas, M, Liechty, EA, McClure, EM, Mitra, D, Mturi, N, Mullany, LC, Newton, CR, Nosten, F, Parveen, S, Patel, A, Romero, C, Saville, N, Semrau, K, Simões, AF, Soofi, S, Stoll, BJ, Sunder, S, Syed, S, Tielsch, JM, Tinoco, YO, Turner, C, and Vergnano, S
Abstract: Background: Bacterial infections are a leading cause of the 2·9 million annual neonatal deaths. Treatment is usually based on clinical diagnosis of possible severe bacterial infection (pSBI). To guide programme planning, we have undertaken the first estimates of neonatal pSBI, by sex and by region, for sub-Saharan Africa, south Asia, and Latin America. Methods: We included data for pSBI incidence in neonates of 32 weeks' gestation or more (or birthweight ≥1500 g) with livebirth denominator data, undertaking a systematic review and forming an investigator group to obtain unpublished data. We calculated pooled risk estimates for neonatal pSBI and case fatality risk, by sex and by region. We then applied these risk estimates to estimates of livebirths in sub-Saharan Africa, south Asia, and Latin America to estimate cases and associated deaths in 2012. Findings: We included data from 22 studies, for 259 944 neonates and 20 196 pSBI cases, with most of the data (18 of the 22 studies) coming from the investigator group. The pooled estimate of pSBI incidence risk was 7·6% (95% CI 6·1-9·2%) and the case-fatality risk associated with pSBI was 9·8% (7·4-12·2). We estimated that in 2012 there were 6·9 million cases (uncertainty range 5·5 million-8·3 million) of pSBI in neonates needing treatment: 3·5 million (2·8 million-4·2 million) in south Asia, 2·6 million (2·1 million-3·1 million) in sub-Saharan Africa, and 0·8 million (0·7 million-1·0 million) in Latin America. The risk of pSBI was greater in boys (risk ratio 1·12, 95% CI 1·06-1·18) than girls. We estimated that there were 0·68 million (0·46 million-0·92 million) neonatal deaths associated with pSBI in 2012. Interpretation: The need-to-treat population for pSBI in these three regions is high, with ten cases of pSBI diagnosed for each associated neonatal death. Deaths and disability can be reduced through improved prevention, detection, and case management. Funding: The Wellcome Trust and the Bill and Melinda Gates Foundation through grants to Child Health Epidemiology Reference Group (CHERG) and Save the Children's Saving Newborn Lives programme. © 2014 Seale et al.
Published: 2014

7. Changes in health in England, with analysis by English regions and areas of deprivation, 1990-2013 : A systematic analysis for the Global Burden of Disease Study 2013

Author: Newton, J. N., Briggs, A. D. M., Murray, C. J. L., Dicker, D., Foreman, K. J., Wang, H., Naghavi, M., Forouzanfar, M. H., Ohno, S. L., Barber, R. M., Vos, T., Stanaway, J. D., Schmidt, J. C., Hughes, A. J., Fay, D. F. J., Ecob, R., Gresser, C., McKee, M., Rutter, H., Abubakar, I., Ali, R., Anderson, H. R., Banerjee, A., Bennett, D. A., Bernabé, E., Bhui, K. S., Biryukov, S. M., Bourne, R. R., Brayne, C. E. G., Bruce, N. G., Brugha, T. S., Burch, M., Capewell, S., Casey, D., Chowdhury, R., Coates, M. M., Cooper, C., Critchley, J. A., Dargan, P. I., Dherani, M. K., Elliott, P., Ezzati, M., Fenton, K. A., Fraser, M. S., Fürst, T., Greaves, F., Green, M. A., Gunnell, D. J., Hannigan, B. M., Hay, R. J., Hay, S. I., Hemingway, H., Larson, H. J., Looker, K. J., Lunevicius, R., Lyons, R. A., Marcenes, W., Mason-Jones, A. J., Matthews, F. E., Moller, H., Murdoch, M. E., Newton, C. R., Pearce, N., Piel, F. B., Pope, D., Rahimi, K., Rodriguez, Alina, Scarborough, P., Schumacher, A. E., Shiue, I., Smeeth, L., Tedstone, A., Valabhji, J., Williams, H. C., Wolfe, C. D. A., Woolf, A. D., Davis, A. C. J., Newton, J. N., Briggs, A. D. M., Murray, C. J. L., Dicker, D., Foreman, K. J., Wang, H., Naghavi, M., Forouzanfar, M. H., Ohno, S. L., Barber, R. M., Vos, T., Stanaway, J. D., Schmidt, J. C., Hughes, A. J., Fay, D. F. J., Ecob, R., Gresser, C., McKee, M., Rutter, H., Abubakar, I., Ali, R., Anderson, H. R., Banerjee, A., Bennett, D. A., Bernabé, E., Bhui, K. S., Biryukov, S. M., Bourne, R. R., Brayne, C. E. G., Bruce, N. G., Brugha, T. S., Burch, M., Capewell, S., Casey, D., Chowdhury, R., Coates, M. M., Cooper, C., Critchley, J. A., Dargan, P. I., Dherani, M. K., Elliott, P., Ezzati, M., Fenton, K. A., Fraser, M. S., Fürst, T., Greaves, F., Green, M. A., Gunnell, D. J., Hannigan, B. M., Hay, R. J., Hay, S. I., Hemingway, H., Larson, H. J., Looker, K. J., Lunevicius, R., Lyons, R. A., Marcenes, W., Mason-Jones, A. J., Matthews, F. E., Moller, H., Murdoch, M. E., Newton, C. R., Pearce, N., Piel, F. B., Pope, D., Rahimi, K., Rodriguez, Alina, Scarborough, P., Schumacher, A. E., Shiue, I., Smeeth, L., Tedstone, A., Valabhji, J., Williams, H. C., Wolfe, C. D. A., Woolf, A. D., and Davis, A. C. J.
Abstract: Background In the Global Burden of Disease Study 2013 (GBD 2013), knowledge about health and its determinants has been integrated into a comparable framework to inform health policy. Outputs of this analysis are relevant to current policy questions in England and elsewhere, particularly on health inequalities. We use GBD 2013 data on mortality and causes of death, and disease and injury incidence and prevalence to analyse the burden of disease and injury in England as a whole, in English regions, and within each English region by deprivation quintile. We also assess disease and injury burden in England attributable to potentially preventable risk factors. England and the English regions are compared with the remaining constituent countries of the UK and with comparable countries in the European Union (EU) and beyond. Methods We extracted data from the GBD 2013 to compare mortality, causes of death, years of life lost (YLLs), years lived with a disability (YLDs), and disability-adjusted life-years (DALYs) in England, the UK, and 18 other countries (the first 15 EU members [apart from the UK] and Australia, Canada, Norway, and the USA [EU15+]). We extended elements of the analysis to English regions, and subregional areas defined by deprivation quintile (deprivation areas). We used data split by the nine English regions (corresponding to the European boundaries of the Nomenclature for Territorial Statistics level 1 [NUTS 1] regions), and by quintile groups within each English region according to deprivation, thereby making 45 regional deprivation areas. Deprivation quintiles were defined by area of residence ranked at national level by Index of Multiple Deprivation score, 2010. Burden due to various risk factors is described for England using new GBD methodology to estimate independent and overlapping attributable risk for five tiers of behavioural, metabolic, and environmental risk factors. We present results for 306 causes and 2337 sequelae, and 79 risks or risk clu, Export Date: 21 December 2015 CODEN: LANCA Correspondence Address: Newton, J.N.; Public Health England, Wellington HouseUnited Kingdom; email: john.newton@phe.gov.uk References: Murray C.J.L., Richards M.A., Newton J.N., UK health performance: Findings of the Global Burden of Disease Study 2010 (2013) Lancet, 381, pp. 997-1020; Greer S.L., Devolution and divergence in UK health policies (2008) BMJ, 337, p. a2616; England N.H.S., (2014) Five Year Forward View, , http://www.england.nhs.uk/ourwork/futurenhs/, (accessed Aug 24, 2015); Naghavi M., Wang H., Lozano R., Global, regional and national levels of age-specific mortality and 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013 (2015) Lancet, 385, pp. 117-171; Global, regional, and national incidence, prevalence, and years lived with disabilities for 301 acute and chronic diseases and injuries for 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013 (2015) Lancet, 386, pp. 743-800; Global, regional, and national comparative risk assessment of 76 behavioural, environmental, occupational, and metabolic risks or clusters of risks in 188 countries 1990-2013: A systematic analysis for the Global Burden of Disease study 2013 (2015) Lancet, , http://dx.doi.org/10.1016/S0140-6736(15)00128-2, published online Sept 11; Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: Quantifying the epidemiological transition (2015) Lancet, , http://dx.doi.org/10.1016/S0140-6736(15)61340-X, published online Aug 27; Vos T., Flaxman A.D., Naghavi M., Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010 (2012) Lancet, 380, pp. 2163-2196; Murray C.J.L., Ezzati M., Flaxman A.D., GBD 2010: Design, definitions, and metrics (2012) Lancet, 380, p
Published: 2015
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8. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Author: Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Lim, S.S., Vos, T., Flaxman, A.D., Danaei, G., Shibuya, K., Adair-Rohani, H., Amann, M., Anderson, H.R., Andrews, K.G., Aryee, M., Atkinson, C., Bacchus, L.J., Bahalim, A.N., Balakrishnan, K., Balmes, J., Barker-Collo, S., Baxter, A., Bell, M.L., Blore, J.D., Blyth, F., Bonner, C., Borges, G., Bourne, R., Boussinesq, M., Brauer, M., Brooks, P., Bruce, N.G., Brunekreef, B., Bryan-Hancock, C., Bucello, C., Buchbinder, R., Bull, F., Burnett, R.T., Byers, T.E., Calabria, B., Carapetis, J., Carnahan, E., Chafe, Z., Charlson, F., Chen, H., Chen, J.S., Cheng, A.T., Child, J.C., Cohen, A., Colson, K.E., Cowie, B.C., Darby, S., Darling, S., Davis, A., Degenhardt, L., Dentener, F., Des Jarlais, D.C., Devries, K., Dherani, M., Ding, E.L., Dorsey, E.R., Driscoll, T., Edmond, K., Ali, S.E., Engell, R.E., Erwin, P.J., Fahimi, S., Falder, G., Farzadfar, F., Ferrari, A., Finucane, M.M., Flaxman, S., Fowkes, F.G.R., Freedman, G., Freeman, M.K., Gakidou, E., Ghosh, S., Giovannucci, E., Gmel, G., Graham, K., Grainger, R., Grant, B., Gunnell, D., Gutierrez, H.R., Hall, W., Hoek, H.W., Hogan, A., Hosgood, H.D., Hoy, D., Hu, H., Hubbell, B.J., Hutchings, S.J., Ibeanusi, S.E., Jacklyn, G.L., Jasrasaria, R., Jonas, J.B., Kan, H., Kanis, J.A., Kassebaum, N., Kawakami, N., Khang, Y-H., Khatibzadeh, S., Khoo, J-P., de Kok, C., Laden, F., Lalloo, R., Lan, Q., Lathlean, T., Leasher, J.L., Leigh, J., Li, Y., Lin, J.K., Lipshultz, S.E., London, S., Lozano, R., Lu, Y., Mak, J., Malekzadeh, R., Mallinger, L., Marcenes, W., March, L., Marks, R., Martin, R., McGale, P., McGrath, J., Mehta, S., Mensah, G.A., Merriman, T.R., Micha, R., Michaud, C., Mishra, V., Hanafiah, K.M., Mokdad, A.A., Morawska, L., Mozaffarian, D., Murphy, T., Naghavi, M., Neal, B., Nelson, P.K., Nolla, J.M., Norman, R., Olives, C., Omer, S. B, Orchard, J., Osborne, R., Ostro, B., Page, A., Pandey, K.D., Parry, C.D.H., Passmore, E., Patra, J., Pearce, N., Pelizzari, P.M., Petzold, M., Phillips, M.R., Pope, D., Pope, C.A., Powles, J., Rao, M., Razavi, H., Rehfuess, E.A., Rehm, J.T., Ritz, B., Rivara, F.P., Roberts, T., Robinson, C., Rodriguez-Portales, J.A., Romieu, I., Room, R., Rosenfeld, L.C., Roy, A., Rushton, L., Salomon, J.A., Sampson, U., Sanchez-Riera, L., Sanman, E., Sapkota, A., Seedat, S., Shi, P., Shield, K., Shivakoti, R., Singh, G.M., Sleet, D.A., Smith, E., Smith, K.R., Stapelberg, N.J.C., Steenland, K., Stöckl, H., Stovner, L.J., Straif, K., Straney, L., Thurston, G.D., Tran, J.H., van Dingenen, R., van Donkelaar, A., Veerman, J.L., Vijayakumar, L., Weintraub, R., Weissman, M.M., White, R.A., Whiteford, H., Wiersma, S.T., Wilkinson, J.D., Williams, H.C., Williams, W., Wilson, N., Woolf, A.D., Yip, P., Zielinski, J.M., Lopez, A.D., Murray, C.J.L., Ezzati, M., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Lim, S.S., Vos, T., Flaxman, A.D., Danaei, G., Shibuya, K., Adair-Rohani, H., Amann, M., Anderson, H.R., Andrews, K.G., Aryee, M., Atkinson, C., Bacchus, L.J., Bahalim, A.N., Balakrishnan, K., Balmes, J., Barker-Collo, S., Baxter, A., Bell, M.L., Blore, J.D., Blyth, F., Bonner, C., Borges, G., Bourne, R., Boussinesq, M., Brauer, M., Brooks, P., Bruce, N.G., Brunekreef, B., Bryan-Hancock, C., Bucello, C., Buchbinder, R., Bull, F., Burnett, R.T., Byers, T.E., Calabria, B., Carapetis, J., Carnahan, E., Chafe, Z., Charlson, F., Chen, H., Chen, J.S., Cheng, A.T., Child, J.C., Cohen, A., Colson, K.E., Cowie, B.C., Darby, S., Darling, S., Davis, A., Degenhardt, L., Dentener, F., Des Jarlais, D.C., Devries, K., Dherani, M., Ding, E.L., Dorsey, E.R., Driscoll, T., Edmond, K., Ali, S.E., Engell, R.E., Erwin, P.J., Fahimi, S., Falder, G., Farzadfar, F., Ferrari, A., Finucane, M.M., Flaxman, S., Fowkes, F.G.R., Freedman, G., Freeman, M.K., Gakidou, E., Ghosh, S., Giovannucci, E., Gmel, G., Graham, K., Grainger, R., Grant, B., Gunnell, D., Gutierrez, H.R., Hall, W., Hoek, H.W., Hogan, A., Hosgood, H.D., Hoy, D., Hu, H., Hubbell, B.J., Hutchings, S.J., Ibeanusi, S.E., Jacklyn, G.L., Jasrasaria, R., Jonas, J.B., Kan, H., Kanis, J.A., Kassebaum, N., Kawakami, N., Khang, Y-H., Khatibzadeh, S., Khoo, J-P., de Kok, C., Laden, F., Lalloo, R., Lan, Q., Lathlean, T., Leasher, J.L., Leigh, J., Li, Y., Lin, J.K., Lipshultz, S.E., London, S., Lozano, R., Lu, Y., Mak, J., Malekzadeh, R., Mallinger, L., Marcenes, W., March, L., Marks, R., Martin, R., McGale, P., McGrath, J., Mehta, S., Mensah, G.A., Merriman, T.R., Micha, R., Michaud, C., Mishra, V., Hanafiah, K.M., Mokdad, A.A., Morawska, L., Mozaffarian, D., Murphy, T., Naghavi, M., Neal, B., Nelson, P.K., Nolla, J.M., Norman, R., Olives, C., Omer, S. B, Orchard, J., Osborne, R., Ostro, B., Page, A., Pandey, K.D., Parry, C.D.H., Passmore, E., Patra, J., Pearce, N., Pelizzari, P.M., Petzold, M., Phillips, M.R., Pope, D., Pope, C.A., Powles, J., Rao, M., Razavi, H., Rehfuess, E.A., Rehm, J.T., Ritz, B., Rivara, F.P., Roberts, T., Robinson, C., Rodriguez-Portales, J.A., Romieu, I., Room, R., Rosenfeld, L.C., Roy, A., Rushton, L., Salomon, J.A., Sampson, U., Sanchez-Riera, L., Sanman, E., Sapkota, A., Seedat, S., Shi, P., Shield, K., Shivakoti, R., Singh, G.M., Sleet, D.A., Smith, E., Smith, K.R., Stapelberg, N.J.C., Steenland, K., Stöckl, H., Stovner, L.J., Straif, K., Straney, L., Thurston, G.D., Tran, J.H., van Dingenen, R., van Donkelaar, A., Veerman, J.L., Vijayakumar, L., Weintraub, R., Weissman, M.M., White, R.A., Whiteford, H., Wiersma, S.T., Wilkinson, J.D., Williams, H.C., Williams, W., Wilson, N., Woolf, A.D., Yip, P., Zielinski, J.M., Lopez, A.D., Murray, C.J.L., and Ezzati, M.
Published: 2012

9. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Author: Vos, T, Flaxman, AD, Naghavi, M, Lozano, R, Michaud, C, Ezzati, M, Shibuya, K, Salomon, JA, Abdalla, S, Aboyans, V, Abraham, J, Ackerman, I, Aggarwal, R, Ahn, SY, Ali, MK, Alvarado, M, Anderson, HR, Anderson, LM, Andrews, KG, Atkinson, C, Baddour, LM, Bahalim, AN, Barker-Collo, S, Barrero, LH, Bartels, DH, Basanez, M-G, Baxter, A, Bell, ML, Benjamin, EJ, Bennett, D, Bernabe, E, Bhalla, K, Bhandari, B, Bikbov, B, Bin Abdulhak, A, Birbeck, G, Black, JA, Blencowe, H, Blore, JD, Blyth, F, Bolliger, I, Bonaventure, A, Boufous, SA, Bourne, R, Boussinesq, M, Braithwaite, T, Brayne, C, Bridgett, L, Brooker, S, Brooks, P, Brugha, TS, Bryan-Hancock, C, Bucello, C, Buchbinder, R, Buckle, GR, Budke, CM, Burch, M, Burney, P, Burstein, R, Calabria, B, Campbell, B, Canter, CE, Carabin, H, Carapetis, J, Carmona, L, Cella, C, Charlson, F, Chen, H, Cheng, AT-A, Chou, D, Chugh, SS, Coffeng, LE, Colan, SD, Colquhoun, S, Colson, KE, Condon, J, Connor, MD, Cooper, LT, Corriere, M, Cortinovis, M, de Vaccaro, KC, Couser, W, Cowie, BC, Criqui, MH, Cross, M, Dabhadkar, KC, Dahiya, M, Dahodwala, N, Damsere-Derry, J, Danaei, G, Davis, A, De Leo, D, Degenhardt, L, Dellavalle, R, Delossantos, A, Denenberg, J, Derrett, S, Des Jarlais, DC, Dharmaratne, SD, Dherani, M, Diaz-Torne, C, Dolk, H, Dorsey, ER, Driscoll, T, Duber, H, Ebel, B, Edmond, K, Elbaz, A, Ali, SE, Erskine, H, Erwin, PJ, Espindola, P, Ewoigbokhan, SE, Farzadfar, F, Feigin, V, Felson, DT, Ferrari, A, Ferri, CP, Fevre, EM, Finucane, MM, Flaxman, S, Flood, L, Foreman, K, Forouzanfar, MH, Fowkes, FGR, Franklin, R, Fransen, M, Freeman, MK, Gabbe, BJ, Gabriel, SE, Gakidou, E, Ganatra, HA, Garcia, B, Gaspari, F, Gillum, RF, Gmel, G, Gosselin, R, Grainger, R, Groeger, J, Guillemin, F, Gunnell, D, Gupta, R, Haagsma, J, Hagan, H, Halasa, YA, Hall, W, Haring, D, Maria Haro, J, Harrison, JE, Havmoeller, R, Hay, RJ, Higashi, H, Hill, C, Hoen, B, Hoffman, H, Hotez, PJ, Hoy, D, Huang, JJ, Ibeanusi, SE, Jacobsen, KH, James, SL, Jarvis, D, Jasrasaria, R, Jayaraman, S, Johns, N, Jonas, JB, Karthikeyan, G, Kassebaum, N, Kawakami, N, Keren, A, Khoo, J-P, King, CH, Knowlton, LM, Kobusingye, O, Koranteng, A, Krishnamurthi, R, Lalloo, R, Laslett, LL, Lathlean, T, Leasher, JL, Lee, YY, Leigh, J, Lim, SS, Limb, E, Lin, JK, Lipnick, M, Lipshultz, SE, Liu, W, Loane, M, Ohno, SL, Lyons, R, Ma, J, Mabweijano, J, MacIntyre, MF, Malekzadeh, R, Mallinger, L, Manivannan, S, Marcenes, W, March, L, Margolis, DJ, Marks, GB, Marks, R, Matsumori, A, Matzopoulos, R, Mayosi, BM, McAnulty, JH, McDermott, MM, McGill, N, McGrath, J, Elena Medina-Mora, M, Meltzer, M, Mensah, GA, Merriman, TR, Meyer, A-C, Miglioli, V, Miller, M, Miller, TR, Mitchell, PB, Mocumbi, AO, Moffitt, TE, Mokdad, AA, Monasta, L, Montico, M, Moradi-Lakeh, M, Moran, A, Morawska, L, Mori, R, Murdoch, ME, Mwaniki, MK, Naidoo, K, Nair, MN, Naldi, L, Narayan, KMV, Nelson, PK, Nelson, RG, Nevitt, MC, Newton, CR, Nolte, S, Norman, P, Norman, R, O'Donnell, M, O'Hanlon, S, Olives, C, Omer, SB, Ortblad, K, Osborne, R, Ozgediz, D, Page, A, Pahari, B, Pandian, JD, Rivero, AP, Patten, SB, Pearce, N, Perez Padilla, R, Perez-Ruiz, F, Perico, N, Pesudovs, K, Phillips, D, Phillips, MR, Pierce, K, Pion, S, Polanczyk, GV, Polinder, S, Pope, CA, Popova, S, Porrini, E, Pourmalek, F, Prince, M, Pullan, RL, Ramaiah, KD, Ranganathan, D, Razavi, H, Regan, M, Rehm, JT, Rein, DB, Remuzzi, G, Richardson, K, Rivara, FP, Roberts, T, Robinson, C, De Leon, FR, Ronfani, L, Room, R, Rosenfeld, LC, Rushton, L, Sacco, RL, Saha, S, Sampson, U, Sanchez-Riera, L, Sanman, E, Schwebel, DC, Scott, JG, Segui-Gomez, M, Shahraz, S, Shepard, DS, Shin, H, Shivakoti, R, Singh, D, Singh, GM, Singh, JA, Singleton, J, Sleet, DA, Sliwa, K, Smith, E, Smith, JL, Stapelberg, NJC, Steer, A, Steiner, T, Stolk, WA, Stovner, LJ, Sudfeld, C, Syed, S, Tamburlini, G, Tavakkoli, M, Taylor, HR, Taylor, JA, Taylor, WJ, Thomas, B, Thomson, WM, Thurston, GD, Tleyjeh, IM, Tonelli, M, Towbin, JRA, Truelsen, T, Tsilimbaris, MK, Ubeda, C, Undurraga, EA, van der Werf, MJ, van Os, J, Vavilala, MS, Venketasubramanian, N, Wang, M, Wang, W, Watt, K, Weatherall, DJ, Weinstock, MA, Weintraub, R, Weisskopf, MG, Weissman, MM, White, RA, Whiteford, H, Wiersma, ST, Wilkinson, JD, Williams, HC, Williams, SRM, Witt, E, Wolfe, F, Woolf, AD, Wulf, S, Yeh, P-H, Zaidi, AKM, Zheng, Z-J, Zonies, D, Lopez, AD, Murray, CJL, Vos, T, Flaxman, AD, Naghavi, M, Lozano, R, Michaud, C, Ezzati, M, Shibuya, K, Salomon, JA, Abdalla, S, Aboyans, V, Abraham, J, Ackerman, I, Aggarwal, R, Ahn, SY, Ali, MK, Alvarado, M, Anderson, HR, Anderson, LM, Andrews, KG, Atkinson, C, Baddour, LM, Bahalim, AN, Barker-Collo, S, Barrero, LH, Bartels, DH, Basanez, M-G, Baxter, A, Bell, ML, Benjamin, EJ, Bennett, D, Bernabe, E, Bhalla, K, Bhandari, B, Bikbov, B, Bin Abdulhak, A, Birbeck, G, Black, JA, Blencowe, H, Blore, JD, Blyth, F, Bolliger, I, Bonaventure, A, Boufous, SA, Bourne, R, Boussinesq, M, Braithwaite, T, Brayne, C, Bridgett, L, Brooker, S, Brooks, P, Brugha, TS, Bryan-Hancock, C, Bucello, C, Buchbinder, R, Buckle, GR, Budke, CM, Burch, M, Burney, P, Burstein, R, Calabria, B, Campbell, B, Canter, CE, Carabin, H, Carapetis, J, Carmona, L, Cella, C, Charlson, F, Chen, H, Cheng, AT-A, Chou, D, Chugh, SS, Coffeng, LE, Colan, SD, Colquhoun, S, Colson, KE, Condon, J, Connor, MD, Cooper, LT, Corriere, M, Cortinovis, M, de Vaccaro, KC, Couser, W, Cowie, BC, Criqui, MH, Cross, M, Dabhadkar, KC, Dahiya, M, Dahodwala, N, Damsere-Derry, J, Danaei, G, Davis, A, De Leo, D, Degenhardt, L, Dellavalle, R, Delossantos, A, Denenberg, J, Derrett, S, Des Jarlais, DC, Dharmaratne, SD, Dherani, M, Diaz-Torne, C, Dolk, H, Dorsey, ER, Driscoll, T, Duber, H, Ebel, B, Edmond, K, Elbaz, A, Ali, SE, Erskine, H, Erwin, PJ, Espindola, P, Ewoigbokhan, SE, Farzadfar, F, Feigin, V, Felson, DT, Ferrari, A, Ferri, CP, Fevre, EM, Finucane, MM, Flaxman, S, Flood, L, Foreman, K, Forouzanfar, MH, Fowkes, FGR, Franklin, R, Fransen, M, Freeman, MK, Gabbe, BJ, Gabriel, SE, Gakidou, E, Ganatra, HA, Garcia, B, Gaspari, F, Gillum, RF, Gmel, G, Gosselin, R, Grainger, R, Groeger, J, Guillemin, F, Gunnell, D, Gupta, R, Haagsma, J, Hagan, H, Halasa, YA, Hall, W, Haring, D, Maria Haro, J, Harrison, JE, Havmoeller, R, Hay, RJ, Higashi, H, Hill, C, Hoen, B, Hoffman, H, Hotez, PJ, Hoy, D, Huang, JJ, Ibeanusi, SE, Jacobsen, KH, James, SL, Jarvis, D, Jasrasaria, R, Jayaraman, S, Johns, N, Jonas, JB, Karthikeyan, G, Kassebaum, N, Kawakami, N, Keren, A, Khoo, J-P, King, CH, Knowlton, LM, Kobusingye, O, Koranteng, A, Krishnamurthi, R, Lalloo, R, Laslett, LL, Lathlean, T, Leasher, JL, Lee, YY, Leigh, J, Lim, SS, Limb, E, Lin, JK, Lipnick, M, Lipshultz, SE, Liu, W, Loane, M, Ohno, SL, Lyons, R, Ma, J, Mabweijano, J, MacIntyre, MF, Malekzadeh, R, Mallinger, L, Manivannan, S, Marcenes, W, March, L, Margolis, DJ, Marks, GB, Marks, R, Matsumori, A, Matzopoulos, R, Mayosi, BM, McAnulty, JH, McDermott, MM, McGill, N, McGrath, J, Elena Medina-Mora, M, Meltzer, M, Mensah, GA, Merriman, TR, Meyer, A-C, Miglioli, V, Miller, M, Miller, TR, Mitchell, PB, Mocumbi, AO, Moffitt, TE, Mokdad, AA, Monasta, L, Montico, M, Moradi-Lakeh, M, Moran, A, Morawska, L, Mori, R, Murdoch, ME, Mwaniki, MK, Naidoo, K, Nair, MN, Naldi, L, Narayan, KMV, Nelson, PK, Nelson, RG, Nevitt, MC, Newton, CR, Nolte, S, Norman, P, Norman, R, O'Donnell, M, O'Hanlon, S, Olives, C, Omer, SB, Ortblad, K, Osborne, R, Ozgediz, D, Page, A, Pahari, B, Pandian, JD, Rivero, AP, Patten, SB, Pearce, N, Perez Padilla, R, Perez-Ruiz, F, Perico, N, Pesudovs, K, Phillips, D, Phillips, MR, Pierce, K, Pion, S, Polanczyk, GV, Polinder, S, Pope, CA, Popova, S, Porrini, E, Pourmalek, F, Prince, M, Pullan, RL, Ramaiah, KD, Ranganathan, D, Razavi, H, Regan, M, Rehm, JT, Rein, DB, Remuzzi, G, Richardson, K, Rivara, FP, Roberts, T, Robinson, C, De Leon, FR, Ronfani, L, Room, R, Rosenfeld, LC, Rushton, L, Sacco, RL, Saha, S, Sampson, U, Sanchez-Riera, L, Sanman, E, Schwebel, DC, Scott, JG, Segui-Gomez, M, Shahraz, S, Shepard, DS, Shin, H, Shivakoti, R, Singh, D, Singh, GM, Singh, JA, Singleton, J, Sleet, DA, Sliwa, K, Smith, E, Smith, JL, Stapelberg, NJC, Steer, A, Steiner, T, Stolk, WA, Stovner, LJ, Sudfeld, C, Syed, S, Tamburlini, G, Tavakkoli, M, Taylor, HR, Taylor, JA, Taylor, WJ, Thomas, B, Thomson, WM, Thurston, GD, Tleyjeh, IM, Tonelli, M, Towbin, JRA, Truelsen, T, Tsilimbaris, MK, Ubeda, C, Undurraga, EA, van der Werf, MJ, van Os, J, Vavilala, MS, Venketasubramanian, N, Wang, M, Wang, W, Watt, K, Weatherall, DJ, Weinstock, MA, Weintraub, R, Weisskopf, MG, Weissman, MM, White, RA, Whiteford, H, Wiersma, ST, Wilkinson, JD, Williams, HC, Williams, SRM, Witt, E, Wolfe, F, Woolf, AD, Wulf, S, Yeh, P-H, Zaidi, AKM, Zheng, Z-J, Zonies, D, Lopez, AD, and Murray, CJL
Abstract: BACKGROUND: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs). METHODS: Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis. FINDINGS: Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350,000 cases per 1 million people. Prevalence and severity of health loss were weakly cor
Published: 2012

10. Does Reduced Indoor Air Pollution Exposure have Similar Impact on Upper and Lower Respiratory Symptoms?

Author: Bruce, N, primary, Pope, D, additional, Diaz, E, additional, Dherani, M, additional, Diaz, A, additional, and Smith-Sivertsen, T, additional
Published: 2007
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11. Indoor Air Pollution and Childhood Pneumonia: Impact of Reduced Exposure on Severity and Clinical Features

Author: Dherani, M K, primary, Diaz, A, additional, Jenny, A, additional, Thomsan, L, additional, Smith, K, additional, and Bruce, N, additional
Published: 2007
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12. Indoor air pollution from unprocessed solid fuel use and pneumonia risk in children aged under five years: a systematic review and meta-analysis.

Author: Dherani M, Pope D, Mascarenhas M, Smith KR, Weber M, and Bruce N
Abstract: Reduction of indoor air pollution (IAP) exposure from solid fuel use is a potentially important intervention for childhood pneumonia prevention. This review updates a prior meta-analysis and investigates whether risk varies by etiological agent and pneumonia severity among children aged less than 5 years who are exposed to unprocessed solid fuels. Searches were made of electronic databases (including Africa, China and Latin America) without language restriction. Search terms covered all sources of IAP and wide-ranging descriptions of acute lower respiratory infections, including viral and bacterial agents. From 5317 studies in the main electronic databases (plus 307 African and Latin American, and 588 Chinese studies, in separate databases), 25 were included in the review and 24 were suitable for meta-analysis. Due to substantial statistical heterogeneity, random effects models were used. The overall pooled odds ratio was 1.78 (95% confidence interval, CI: 1.45-2.18), almost unchanged at 1.79 (95% CI: 1.26-2.21) after exclusion of studies with low exposure prevalence (< 15%) and one high outlier. There was evidence of publication bias, and the implications for the results are explored. Sensitivity subanalyses assessed the impact of control selection, adjustment for confounding, exposure and outcome assessment, and age, but no strong effects were identified. Evidence on respiratory syncytial virus was conflicting, while risk for severe or fatal pneumonia was similar to or higher than that for all pneumonia. Despite heterogeneity, this analysis demonstrated sufficient consistency to conclude that risk of pneumonia in young children is increased by exposure to unprocessed solid fuels by a factor of 1.8. Greater efforts are now required to implement effective interventions. [ABSTRACT FROM AUTHOR]
Published: 2008

13. Pneumonia case-finding in the RESPIRE Guatemala indoor air pollution trial: standardizing methods for resource-poor settings.

Author: Bruce N, Weber M, Arana B, Diaz A, Jenny A, Thompson L, McCracken J, Dherani M, Juarez D, Ordonez S, Klein R, and Smith KR
Abstract: OBJECTIVE: Trials of environmental risk factors and acute lower respiratory infections (ALRI) face a double challenge: implementing sufficiently sensitive and specific outcome assessments, and blinding. We evaluate methods used in the first randomized exposure study of pollution indoors and respiratory effects (RESPIRE): a controlled trial testing the impact of reduced indoor air pollution on ALRI, conducted among children 90% of children meeting ALRI criteria, of whom about 70% attended a physician. Referrals for cough without respiratory signs and self-referrals contributed 19.0% and 17.9% of physician-diagnosed ALRI cases respectively. Intervention group attendance following ALRI referral was 7% higher than controls, a trend also seen in compliance with RSV tests and CXR. There was no evidence of bias by intervention status in fieldworker classification or physician diagnosis. Incidence of fieldworker ALRI (1.12 episodes/child/year) is consistent with high sensitivity and low specificity; incidence of physician-diagnosed ALRI (0.44 episodes/child/year) is consistent with comparable studies. CONCLUSION: The combination of case-finding methods achieved good sensitivity and specificity, but intervention cases had greater likelihood of reaching the physician and being investigated. There was no evidence of bias in fieldworkers classifications despite lack of concealment at home visits. Pulse oximetry offers practical, objective severity assessment for field studies of ALRI. Copyright © 2007 World Health Organization [ABSTRACT FROM AUTHOR]
Published: 2007
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14. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author: Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abera, Semaw Ferede, Abraha, Haftom Niguse, Abu-Raddad, Laith J., Abu-Rmeileh, Niveen M. E., Adedeji, Isaac Akinkunmi, Adedoyin, Rufus Adesoji, Adetifa, Ifedayo Morayo O., Adetokunboh, Olatunji, Afshin, Ashkan, Aggarwal, Rakesh, Agrawal, Anurag, Agrawal, Sutapa, Ahmad Kiadaliri, Aliasghar, Ahmed, Muktar Beshir, Aichour, Miloud Taki Eddine, Aichour, Amani Nidhal, Aichour, Ibthiel, Aiyar, Sneha, Akanda, Ali Shafqat, Akinyemiju, Tomi F., Akseer, Nadia, Al Lami, Faris Hasan, Alabed, Samer, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alasfoor, Deena, Aldridge, Robert William, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Alhabib, Samia, Ali, Raghib, Alizadeh-Navaei, Reza, Aljunid, Syed M., Alkaabi, Juma M., Alkerwi, Ala'a, Alla, François, Allam, Shalini D., Allebeck, Peter, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Amare, Azmeraw T., Ameh, Emmanuel A., Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T., Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon Weldegebreal, Asghar, Rana Jawad, Assadi, Reza, Assaye, Ashagre Molla, Atey, Tesfay Mehari, Atre, Sachin R., Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Babalola, Tesleem Kayode, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Balalla, Shivanthi, Barac, Aleksandra, Barber, Ryan M., Barboza, Miguel A., Barker-Collo, Suzanne L., Bärnighausen, Till, Barquera, Simon, Barregard, Lars, Barrero, Lope H., Baune, Bernhard T., Bazargan-Hejazi, Shahrzad, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L., Bello, Aminu K., Bennett, Derrick A., Bennett, James R., Bensenor, Isabela M., Benson, Jennifer, Berhane, Adugnaw, Berhe, Derbew Fikadu, Bernabé, Eduardo, Beuran, Mircea, Beyene, Addisu Shunu, Bhala, Neeraj, Bhansali, Anil, Bhaumik, Soumyadeep, Bhutta, Zulfiqar A., Bicer, Burcu Kucuk, Bidgoli, Hassan Haghparast, Bikbov, Boris, Birungi, Charles, Biryukov, Stan, Bisanzio, Donal, Bizuayehu, Habtamu Mellie, Bjerregaard, Peter, Blosser, Christopher D., Boneya, Dube Jara, Boufous, Soufiane, Bourne, Rupert R. A., Brazinova, Alexandra, Breitborde, Nicholas J. K., Brenner, Hermann, Brugha, Traolach S., Bukhman, Gene, Bulto, Lemma Negesa Bulto, Bumgarner, Blair Randal, Burch, Michael, Butt, Zahid A., Cahill, Leah E., Cahuana-Hurtado, Lucero, Campos-Nonato, Ismael Ricardo, Car, Josip, Car, Mate, Cárdenas, Rosario, Carpenter, David O., Carrero, Juan Jesus, Carter, Austin, Castañeda-Orjuela, Carlos A., Castro, Franz F., Castro, Ruben Estanislao, Catalá-López, Ferrán, Chen, Honglei, Chiang, Peggy Pei-Chia, Chibalabala, Mirriam, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Choi, Jee-Young Jasmine, Christensen, Hanne, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Cirillo, Massimo, Cohen, Aaron J., Colquhoun, Samantha M., Coresh, Josef, Criqui, Michael H., Cromwell, Elizabeth A., Crump, John A., Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., das Neves, José, Davey, Gail, Davitoiu, Dragos V., Davletov, Kairat, de Courten, Barbora, De Leo, Diego, Degenhardt, Louisa, Deiparine, Selina, Dellavalle, Robert P., Deribe, Kebede, Deribew, Amare, Des Jarlais, Don C., Dey, Subhojit, Dharmaratne, Samath D., Dherani, Mukesh K., Diaz-Torné, Cesar, Ding, Eric L., Dixit, Priyanka, Djalalinia, Shirin, Do, Huyen Phuc, Doku, David Teye, Donnelly, Christl Ann, dos Santos, Kadine Priscila Bender, Douwes-Schultz, Dirk, Driscoll, Tim R., Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Dwivedi, Laxmi Kant, Ebrahimi, Hedyeh, El Bcheraoui, Charbel, Ellingsen, Christian Lycke, Enayati, Ahmadali, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Eshetie, Setegn, Eshrati, Babak, Eskandarieh, Sharareh, Esteghamati, Alireza, Estep, Kara, Fanuel, Fanuel Belayneh Bekele, Faro, André, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Fernandes, João C., Feyissa, Tesfaye Regassa, Filip, Irina, Fischer, Florian, Foigt, Nataliya, Foreman, Kyle J., Frank, Tahvi, Franklin, Richard C., Fraser, Maya, Friedman, Joseph, Frostad, Joseph J., Fullman, Nancy, Fürst, Thomas, Furtado, Joao M., Futran, Neal D., Gakidou, Emmanuela, Gambashidze, Ketevan, Gamkrelidze, Amiran, Gankpé, Fortuné Gbètoho, Garcia-Basteiro, Alberto L., Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebrekidan, Kahsu Gebrekirstos, Gebremichael, Mengistu Welday, Gelaye, Amha Admasie, Geleijnse, Johanna M., Gemechu, Bikila Lencha, Gemechu, Kasiye Shiferaw, Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W., Gibney, Katherine B., Gill, Paramjit, Gillum, Richard F., Giref, Ababi Zergaw, Girma, Bedilu Weji, Giussani, Giorgia, Goenka, Shifalika, Gomez, Beatriz, Gona, Philimon N., Gopalani, Sameer Vali, Goulart, Alessandra Carvalho, Graetz, Nicholas, Gugnani, Harish Chander, Gupta, Prakash C., Gupta, Rahul, Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Haagsma, Juanita A., Hafezi-Nejad, Nima, Hakuzimana, Alex, Halasa, Yara A., Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Hareri, Habtamu Abera, Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Roderick J., Hay, Simon I., He, Fei, Heredia-Pi, Ileana Beatriz, Herteliu, Claudiu, Hilawe, Esayas Haregot, Hoek, Hans W., Horita, Nobuyuki, Hosgood, H Dean, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian G., Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, John J., Huang, Hsiang, Iburg, Kim Moesgaard, Igumbor, Ehimario Uche, Ileanu, Bogdan Vasile, Inoue, Manami, Irenso, Asnake Ararsa, Irvine, Caleb M. S., Islam, Sheikh Mohammed Shariful, Islam, Nazrul, Jacobsen, Kathryn H., Jaenisch, Thomas, Jahanmehr, Nader, Jakovljevic, Mihajlo B., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jensen, Paul N., Jha, Vivekanand, Jin, Ye, John, Denny, John, Oommen, Johnson, Sarah Charlotte, Jonas, Jost B., Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, André, Karema, Corine Kakizi, Karimi, Seyed M., Karthikeyan, Ganesan, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J., Kastor, Anshul, Katikireddi, Srinivasa Vittal, Kaul, Anil, Kawakami, Norito, Kazanjan, Konstantin, Keiyoro, Peter Njenga, Kelbore, Sefonias Getachew, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kereselidze, Maia, Kesavachandran, Chandrasekharan Nair, Ketema, Ezra Belay, Khader, Yousef Saleh, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khera, Sahil, Khoja, Abdullah Tawfih Abdullah, Khosravi, Mohammad Hossein, Kibret, Getiye Dejenu, Kieling, Christian, Kim, Yun Jin, Kim, Cho-il, Kim, Daniel, Kim, Pauline, Kim, Sungroul, Kimokoti, Ruth W., Kinfu, Yohannes, Kishawi, Sami, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kopec, Jacek A., Kosen, Soewarta, Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael, Krohn, Kristopher J., Kuate Defo, Barthelemy, Kuipers, Ernst J., Kulikoff, Xie Rachel, Kulkarni, Veena S., Kumar, G. Anil, Kumar, Pushpendra, Kumsa, Fekede Asefa, Kutz, Michael, Lachat, Carl, Lagat, Abraham K., Lager, Anton Carl Jonas, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lambert, Nkurunziza, Lan, Qing, Lansingh, Van C., Larson, Heidi J., Larsson, Anders, Laryea, Dennis Odai, Lavados, Pablo M., Laxmaiah, Avula, Lee, Paul H., Leigh, James, Leung, Janni, Leung, Ricky, Levi, Miriam, Li, Yongmei, Liao, Yu, Liben, Misgan Legesse, Lim, Stephen S, Linn, Shai, Lipshultz, Steven E.., Liu, Shiwei, Lodha, Rakesh, Logroscino, Giancarlo, Lopez, Alan D., Lorch, Scott A., Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Lunevicius, Raimundas, Lyons, Ronan A., Ma, Stefan, Macarayan, Erlyn RachelleKing, Machado, Isis Eloah, Mackay, Mark T., Magdy Abd El Razek, Mohammed, Magis-Rodriguez, Carlos, Mahdavi, Mahdi, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Mantovani, Lorenzo G., Manyazewal, Tsegahun, Mapoma, Chabila C., Marczak, Laurie B., Marks, Guy B., Martin, Elena Alvarez, Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlândio, Massano, João, Maulik, Pallab K., Mayosi, Bongani M., Mazidi, Mohsen, McAlinden, Colm, McGarvey, Stephen Theodore, McGrath, John J., McKee, Martin, Mehata, Suresh, Mehndiratta, Man Mohan, Mehta, Kala M., Meier, Toni, Mekonnen, Tefera Chane, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A., Mendoza, Walter, Mengesha, Melkamu Merid, Mengistie, Mubarek Abera, Mengistu, Desalegn Tadese, Menon, Geetha R., Menota, Bereket Gebremichael, Mensah, George A., Meretoja, Tuomo J., Meretoja, Atte, Mezgebe, Haftay Berhane, Micha, Renata, Mikesell, Joseph, Miller, Ted R., Mills, Edward J., Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M., Misganaw, Awoke, Mishra, Shiva Raj, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Kedir Endris, Mohammed, Shafiu, Mohan, Murali B. V., Mohanty, Sanjay K., Mokdad, Ali H., Mollenkopf, Sarah K., Molokhia, Mariam, Monasta, Lorenzo, Montañez Hernandez, Julio Cesar, Montico, Marcella, Mooney, Meghan D., Moore, Ami R., Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Mori, Rintaro, Morrison, Shane D., Mruts, Kalayu Birhane, Mueller, Ulrich O., Mullany, Erin, Muller, Kate, Murray, Christopher J. L., Murthy, Gudlavalleti Venkata Satyanarayana, Murthy, Srinivas, Musa, Kamarul Imran, Nachega, Jean B., Nagata, Chie, Nagel, Gabriele, Naghavi, Mohsen, Naidoo, Kovin S., Nanda, Lipika, Nangia, Vinay, Nascimento, Bruno Ramos, Natarajan, Gopalakrishnan, Negoi, Ionut, Nguyen, Cuong Tat, Nguyen, Quyen Le, Nguyen, Trang Huyen, Nguyen, Grant, Ningrum, Dina Nur Anggraini, Nisar, Muhammad Imran, Nomura, Marika, Nong, Vuong Minh, Norheim, Ole F., Norrving, Bo, Noubiap, Jean Jacques N, Nyakarahuka, Luke, O'Donnell, Martin J, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Oladimeji, Olanrewaju, Olagunju, Andrew Toyin, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oren, Eyal, Ortiz, Alberto, Osgood-Zimmerman, Aaron, Ota, Erika, Owolabi, Mayowa O., Oyekale, Abayomi Samuel, PA, Mahesh, Pacella, Rosana E., Pakhale, Smita, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Park, Eun-Kee, Parsaeian, Mahboubeh, Patel, Tejas, Patten, Scott B., Patton, George C., Paudel, Deepak, Pereira, David M., Perez-Padilla, Rogelio, Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie Beth, Petri, William Arthur, Petzold, Max, Phillips, Michael Robert, Piel, Frédéric B., Pigott, David M., Pishgar, Farhad, Plass, Dietrich, Polinder, Suzanne, Popova, Svetlana, Postma, Maarten J., Poulton, Richie G., Pourmalek, Farshad, Prasad, Narayan, Purwar, Manorama, Qorbani, Mostafa, Quintanilla, Beatriz Paulina Ayala, Rabiee, Rynaz H. S., Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Afarin, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rahman, Mahfuzar, Rai, Rajesh Kumar, Rajsic, Sasa, Ram, Usha, Rana, Saleem M., Ranabhat, Chhabi Lal, Rao, Paturi Vishnupriya, Rawaf, Salman, Ray, Sarah E., Rego, Maria Albertina Santiago, Rehm, Jürgen, Reiner, Robert C., Remuzzi, Giuseppe, Renzaho, Andre M. N., Resnikoff, Serge, Rezaei, Satar, Rezai, Mohammad Sadegh, Ribeiro, Antonio L., Rivas, Jacqueline Castillo, Rokni, Mohammad Bagher, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A., Rothenbacher, Dietrich, Roy, Ambuj, Rubagotti, Enrico, Ruhago, George Mugambage, Saadat, Soheil, Sabde, Yogesh Damodar, Sachdev, Perminder S., Sadat, Nafis, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Salama, Joseph, Salamati, Payman, Salomon, Joshua A., Salvi, Sundeep Santosh, Samy, Abdallah M., Sanabria, Juan Ramon, Sanchez-Niño, Maria Dolores, Santos, Itamar S., Santric Milicevic, Milena M., Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Sawhney, Monika, Saxena, Sonia, Saylan, Mete I., Schmidt, Maria Inês, Schneider, Ione J. C., Schulhofer-Wohl, Sam, Schutte, Aletta E., Schwebel, David C., Schwendicke, Falk, Seedat, Soraya, Seid, Abdulbasit Musa, Sepanlou, Sadaf G., Servan-Mori, Edson E., Shackelford, Katya Anne, Shaheen, Amira, Shahraz, Saeid, Shaikh, Masood Ali, Shamsipour, Mansour, Shamsizadeh, Morteza, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Shen, Jiabin, Shetty, Balakrishna P., Shi, Peilin, Shibuya, Kenji, Shifa, Girma Temam, Shigematsu, Mika, Shiri, Rahman, Shiue, Ivy, Shrime, Mark G., Sigfusdottir, Inga Dora, Silberberg, Donald H., Silpakit, Naris, Silva, Diego Augusto Santos, Silva, João Pedro, Silveira, Dayane Gabriele Alves, Sindi, Shireen, Singh, Jasvinder A., Singh, Prashant Kumar, Singh, Abhishek, Singh, Virendra, Sinha, Dhirendra Narain, Skarbek, Katarzyna A. Kissimova, Skiadaresi, Eirini, Sligar, Amber, Smith, David L., Sobaih, Badr H. A., Sobngwi, Eugene, Soneji, Samir, Soriano, Joan B., Sreeramareddy, Chandrashekhar T., Srinivasan, Vinay, Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J., Steiner, Caitlyn, Stöckl, Heidi, Stokes, Mark Andrew, Strong, Mark, Sufiyan, Muawiyyah Babale, Suliankatchi, Rizwan Abdulkader, Sunguya, Bruno F., Sur, Patrick J., Swaminathan, Soumya, Sykes, Bryan L., Szoeke, Cassandra E. I., Tabarés-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Tadese, Fentaw, Tandon, Nikhil, Tanne, David, Tarajia, Musharaf, Tavakkoli, Mohammad, Taveira, Nuno, Tehrani-Banihashemi, Arash, Tekelab, Tesfalidet, Tekle, Dejen Yemane, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Tesema, Cheru Leshargie, Tesssema, Belay, Theis, Andrew, Thomas, Nihal, Thompson, Alex H., Thomson, Alan J., Thrift, Amanda G., Tiruye, Tenaw Yimer, Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Tortajada, Miguel, Tran, Bach Xuan, Truelsen, Thomas, Trujillo, Ulises, Tsilimparis, Nikolaos, Tuem, Kald Beshir, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley Nnanna, Undurraga, Eduardo A., Uthman, Olalekan A., Uzochukwu, Benjamin S. Chudi, van Boven, Job F. M., Varakin, Yuri Y., Varughese, Santosh, Vasankari, Tommi, Vasconcelos, Ana Maria Nogales, Velasquez, Ilais Moreno, Venketasubramanian, Narayanaswamy, Vidavalur, Ramesh, Violante, Francesco S., Vishnu, Abhishek, Vladimirov, Sergey K., Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Vos, Theo, Waid, Jillian L., Wakayo, Tolassa, Wang, Haidong, Wang, Yuan-Pang, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Wesana, Joshua, Wijeratne, Tissa, Wilkinson, James D., Wiysonge, Charles Shey, Woldeyes, Belete Getahun, Wolfe, Charles D. A., Workicho, Abdulhalik, Workie, Shimelash Bitew, Xavier, Denis, Xu, Gelin, Yaghoubi, Mohsen, Yakob, Bereket, Yalew, Ayalnesh Zemene, Yan, Lijing L., Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yimam, Hassen Hamid, Yip, Paul, Yirsaw, Biruck Desalegn, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z., Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zeeb, Hajo, Zenebe, Zerihun Menlkalew, Zerfu, Taddese Alemu, Zhang, Anthony Lin, Zhang, Xueying, Zodpey, Sanjay, Zuhlke, Liesl Joanna, HASH(0x5651ca1ecb00), Viðskiptadeild (HR), School of Business (RU), Háskólinn í Reykjavík, Reykjavik University, Wang, Haidong, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abera, Semaw Ferede, Abraha, Haftom Niguse, Abu-Raddad, Laith J., Abu-Rmeileh, Niveen M.E., Adedeji, Isaac Akinkunmi, Adedoyin, Rufus Adesoji, Adetifa, Ifedayo Morayo O., Adetokunboh, Olatunji, Afshin, Ashkan, Aggarwal, Rakesh, Agrawal, Anurag, Agrawal, Sutapa, Ahmad Kiadaliri, Aliasghar, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibthiel, Aichour, Miloud Taki Eddine, Aiyar, Sneha, Akanda, Ali Shafqat, Akinyemiju, Tomi F., Akseer, Nadia, Al-Eyadhy, Ayman, Al Lami, Faris Hasan, Alabed, Samer, Alahdab, Fare, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alasfoor, Deena, Aldridge, Robert William, Alene, Kefyalew Addi, Alhabib, Samia, Ali, Raghib, Alizadeh-Navaei, Reza, Aljunid, Syed M., Alkaabi, Juma M., Alkerwi, Ala'a, Alla, Françoi, Allam, Shalini D., Allebeck, Peter, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A., Martin, Elena Alvarez, Alvis-Guzman, Nelson, Amare, Azmeraw T., Ameh, Emmanuel A., Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T., Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon Weldegebreal, Asghar, Rana Jawad, Assadi, Reza, Atey, Tesfay Mehari, Atre, Sachin R., Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G. 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Geleijnse, J, Gemechu, B, Gemechu, K, Genova-Maleras, R, Gesesew, H, Gething, P, Gibney, K, Gill, P, Gillum, R, Giref, A, Girma, B, Giussani, G, Goenka, S, Gomez, B, Gona, P, Gopalani, S, Goulart, A, Graetz, N, Gugnani, H, Gupta, P, Gupta, R, Gupta, T, Gupta, V, Haagsma, J, Hafezi-Nejad, N, Haghparast Bidgoli, H, Hakuzimana, A, Halasa, Y, Hamadeh, R, Hambisa, M, Hamidi, S, Hammami, M, Hancock, J, Handal, A, Hankey, G, Hao, Y, Harb, H, Hareri, H, Harikrishnan, S, Haro, J, Hassanvand, M, Havmoeller, R, Hay, R, Hay, S, He, F, Heredia-Pi, I, Herteliu, C, Hilawe, E, Hoek, H, Horita, N, Hosgood, H, Hostiuc, S, Hotez, P, Hoy, D, Hsairi, M, Htet, A, Hu, G, Huang, H, Huang, J, Iburg, K, Igumbor, E, Ileanu, B, Inoue, M, Irenso, A, Irvine, C, Islam, N, Jacobsen, K, Jaenisch, T, Jahanmehr, N, Jakovljevic, M, Javanbakht, M, Jayatilleke, A, Jeemon, P, Jensen, P, Jha, V, Jin, Y, John, D, John, O, Johnson, S, Jonas, J, Jürisson, M, Kabir, Z, Kadel, R, Kahsay, A, Kalkonde, Y, Kamal, R, Kan, H, Karch, A, Karema, C, Karimi, S, Karthikeyan, G, Kasaeian, A, Kassaw, N, Kassebaum, N, Kastor, A, Katikireddi, S, Kaul, A, Kawakami, N, Kazanjan, K, Keiyoro, P, Kelbore, S, Kemp, A, Kengne, A, Keren, A, Kereselidze, M, Kesavachandran, C, Ketema, E, Khader, Y, Khalil, I, Khan, E, Khan, G, Khang, Y, Khera, S, Khoja, A, Khosravi, M, Kibret, G, Kieling, C, Kim, C, Kim, D, Kim, P, Kim, S, Kim, Y, Kimokoti, R, Kinfu, Y, Kishawi, S, Kissimova-Skarbek, K, Kissoon, N, Kivimaki, M, Knudsen, A, Kokubo, Y, Kopec, J, Kosen, S, Koul, P, Koyanagi, A, Kravchenko, M, Krohn, K, Kuate Defo, B, Kucuk Bicer, B, Kuipers, E, Kulikoff, X, Kulkarni, V, Kumar, G, Kumar, P, Kumsa, F, Kutz, M, Lachat, C, Lagat, A, Lager, A, Lal, D, Lalloo, R, Lambert, N, Lan, Q, Van Lansingh, C, Larson, H, Larsson, A, Laryea, D, Lavados, P, Laxmaiah, A, Lee, P, Leigh, J, Leung, J, Leung, R, Levi, M, Li, Y, Liao, Y, Liben, M, Lim, S, Linn, S, Lipshultz, S, Liu, S, Lodha, R, Logroscino, G, Lorch, S, Lorkowski, S, Lotufo, P, Lozano, R, Lunevicius, R, Lyons, R, Ma, S, Macarayan, E, Machado, I, Mackay, M, Magdy Abd El Razek, M, Magis-Rodriguez, C, Mahdavi, M, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Malhotra, R, Malta, D, Mantovani, L, Manyazewal, T, Mapoma, C, Marczak, L, Marks, G, Martinez-Raga, J, Martins-Melo, F, Massano, J, Maulik, P, Mayosi, B, Mazidi, M, Mcalinden, C, Mcgarvey, S, Mcgrath, J, Mckee, M, Mehata, S, Mehndiratta, M, Mehta, K, Meier, T, Mekonnen, T, Meles, K, Memiah, P, Memish, Z, Mendoza, W, Mengesha, M, Mengistie, M, Mengistu, D, Menon, G, Menota, B, Mensah, G, Meretoja, A, Meretoja, T, Mezgebe, H, Micha, R, Mikesell, J, Miller, T, Mills, E, Minnig, S, Mirarefin, M, Mirrakhimov, E, Misganaw, A, Mishra, S, Mohammad, K, Mohammadi, A, Mohammed, K, Mohammed, S, Mohan, M, Mohanty, S, Mokdad, A, Molla Assaye, A, Mollenkopf, S, Molokhia, M, Monasta, L, Montañez Hernandez, J, Montico, M, Mooney, M, Moore, A, Moradi-Lakeh, M, Moraga, P, Morawska, L, Moreno Velasquez, I, Mori, R, Morrison, S, Mruts, K, Mueller, U, Mullany, E, Muller, K, Murthy, G, Murthy, S, Musa, K, Nachega, J, Nagata, C, Nagel, G, Naghavi, M, Naidoo, K, Nanda, L, Nangia, V, Nascimento, B, Natarajan, G, Negoi, I, Nguyen, C, Nguyen, G, Nguyen, Q, Nguyen, T, Ningrum, D, Nisar, M, Nomura, M, Nong, V, Norheim, O, Norrving, B, Noubiap, J, Nyakarahuka, L, Obermeyer, C, O'Donnell, M, Ogbo, F, Oh, I, Okoro, A, Oladimeji, O, Olagunju, A, Olusanya, B, Olusanya, J, Oren, E, Ortiz, A, Osgood-Zimmerman, A, Ota, E, Owolabi, M, Oyekale, A, Mahesh, P, Pacella, R, Pakhale, S, Pana, A, Panda, B, Panda-Jonas, S, Park, E, Parsaeian, M, Patel, T, Patten, S, Patton, G, Paudel, D, Pereira, D, Perez-Padilla, R, Perez-Ruiz, F, Perico, N, Pervaiz, A, Pesudovs, K, Peterson, C, Petri, W, Petzold, M, Phillips, M, Piel, F, Pigott, D, Pishgar, F, Plass, D, Polinder, S, Popova, S, Postma, M, Poulton, R, Pourmalek, F, Prasad, N, Purwar, M, Qorbani, M, Rabiee, R, Radfar, A, Rafay, A, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rahman, S, Rai, R, Rajsic, S, Ram, U, Rana, S, Ranabhat, C, Rao, P, Rawaf, S, Ray, S, Rego, M, Rehm, J, Reiner, R, Remuzzi, G, Renzaho, A, Resnikoff, S, Rezaei, S, Rezai, M, Ribeiro, A, Rokni, M, Ronfani, L, Roshandel, G, Roth, G, Rothenbacher, D, Roy, A, Rubagotti, E, Ruhago, G, Saadat, S, Sabde, Y, Sachdev, P, Sadat, N, Safdarian, M, Safi, S, Safiri, S, Sagar, R, Sahathevan, R, Sahebkar, A, Sahraian, M, Salama, J, Salamati, P, Salomon, J, Salvi, S, Samy, A, Sanabria, J, Sanchez-Niño, M, Santos, I, Santric Milicevic, M, Sarmiento-Suarez, R, Sartorius, B, Satpathy, M, Sawhney, M, Saxena, S, Saylan, M, Schmidt, M, Schneider, I, Schutte, A, Schwebel, D, Schwendicke, F, Seedat, S, Seid, A, Sepanlou, S, Servan-Mori, E, Shackelford, K, Shaheen, A, Shahraz, S, Shaikh, M, Shamsipour, M, Shamsizadeh, M, Islam, S, Sharma, J, Sharma, R, She, J, Shen, J, Shetty, B, Shi, P, Shibuya, K, Shigematsu, M, Shiri, R, Shiue, I, Shrime, M, Sigfusdottir, I, Silberberg, D, Silpakit, N, Silva, D, Silva, J, Silveira, D, Sindi, S, Singh, A, Singh, J, Singh, P, Singh, V, Sinha, D, Skiadaresi, E, Sligar, A, Smith, D, Sobaih, B, Sobngwi, E, Soneji, S, Soriano, J, Sreeramareddy, C, Srinivasan, V, Stathopoulou, V, Steel, N, Stein, D, Steiner, C, Stöckl, H, Stokes, M, Strong, M, Sufiyan, M, Suliankatchi, R, Sunguya, B, Sur, P, Swaminathan, S, Sykes, B, Szoeke, C, Tabarés-Seisdedos, R, Tadakamadla, S, Tadese, F, Tandon, N, Tanne, D, Tarajia, M, Tavakkoli, M, Taveira, N, Tehrani-Banihashemi, A, Tekelab, T, Tekle, D, Temam Shifa, G, Temsah, M, Terkawi, A, Tesema, C, Tesssema, B, Theis, A, Thomas, N, Thompson, A, Thomson, A, Thrift, A, Tiruye, T, Tobe-Gai, R, Tonelli, M, Topor-Madry, R, Topouzis, F, Tortajada, M, Tran, B, Truelsen, T, Trujillo, U, Tsilimparis, N, Tuem, K, Tuzcu, E, Tyrovolas, S, Ukwaja, K, Undurraga, E, Uthman, O, Uzochukwu, B, Van Boven, J, Varakin, Y, Varughese, S, Vasankari, T, Vasconcelos, A, Venketasubramanian, N, Vidavalur, R, Violante, F, Vishnu, A, Vladimirov, S, Vlassov, V, Vollset, S, Vos, T, Waid, J, Wakayo, T, Wang, Y, Weichenthal, S, Weiderpass, E, Weintraub, R, Werdecker, A, Wesana, J, Wijeratne, T, Wilkinson, J, Wiysonge, C, Woldeyes, B, Wolfe, C, Workicho, A, Workie, S, Xavier, D, Xu, G, Yaghoubi, M, Yakob, B, Yalew, A, Yan, L, Yano, Y, Yaseri, M, Ye, P, Yimam, H, Yip, P, Yirsaw, B, Yonemoto, N, Yoon, S, Yotebieng, M, Younis, M, Zaidi, Z, El Sayed Zaki, M, Zeeb, H, Zenebe, Z, Zerfu, T, Zhang, A, Zhang, X, Zodpey, S, Zuhlke, L, Lopez, A, Murray, C, Erasmus MC other, Emergency Medicine, Rehabilitation Medicine, Gastroenterology & Hepatology, Public Health, and Neurology
Subjects: Dánarmein, Heilsufar, Dánartíðni, Lífslíkur, Epidemiology, Aldurshópar, ALCOHOL, Börn, Medicine and Health Sciences, Psychology, DEVELOPING-COUNTRIES, Children, Konur, Ungbörn, Tölfræði, Educational status, Aldraðir, Medicine (all), Global burden of disease/statistics and numerical data, DEATH, Men, Þjóðir, Staðtölur, Stillbirth, Sálfræði, World health, SURVIVAL, Income, CHILD-MORTALITY, HEALTH, Burðarmálsdauði, Infants, Age distribution, HIV infections, Child mortality, Alnæmi, Menntun, GBD, Fæðingartíðni, RUSSIAN MORTALITY, Birth rate, Life Expectancy, SDG 3 - Good Health and Well-being, Women, Mortality, METAANALYSIS, Faraldsfræði, HIV, Frjósemi, Fertility, Socioeconomic Factors, Karlar, Barnadauði, Félagshagfræði, Tekjur, Older people, Cause of death/trends, RA
Abstract: Correction in: Group Author(s): GBD 2016 Mortality Collaborators LANCET Volume: 390 Issue: 10106 Pages: E38-E38 Published: OCT 28 2017, Background Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. Methods We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to estimate age-specific and sex-specific death rates for each location-year. Using various international databases, we identified fatal discontinuities, which we defined as increases in the death rate of more than one death per million, resulting from conflict and terrorism, natural disasters, major transport or technological accidents, and a subset of epidemic infectious diseases; these were added to estimates in the relevant years. In 47 countries with an identified peak adult prevalence for HIV/AIDS of more than 0.5% and where VR systems were less than 65% complete, we informed our estimates of age-sex-specific mortality using the Estimation and Projection Package (EPP)-Spectrum model fitted to national HIV/AIDS prevalence surveys and antenatal clinic serosurveillance systems. We estimated stillbirths, early neonatal, late neonatal, and childhood mortality using both survey and VR data in spatiotemporal Gaussian process regression models. We estimated abridged life tables for all location-years using age-specific death rates. We grouped locations into development quintiles based on the Sociodemographic Index (SDI) and analysed mortality trends by quintile. Using spline regression, we estimated the expected mortality rate for each age-sex group as a function of SDI. We identified countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone. Findings Completeness in the registration of deaths increased from 28% in 1970 to a peak of 45% in 2013; completeness was lower after 2013 because of lags in reporting. Total deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age of 25 years. The distribution of annualised rates of change in age-specific mortality rate differed over the period 2000 to 2016 compared with earlier decades: increasing annualised rates of change were less frequent, although rising annualised rates of change still occurred in some locations, particularly for adolescent and younger adult age groups. Rates of stillbirths and under-5 mortality both decreased globally from 1970. Evidence for global convergence of death rates was mixed; although the absolute difference between age-standardised death rates narrowed between countries at the lowest and highest levels of SDI, the ratio of these death rates-a measure of relative inequality-increased slightly. There was a strong shift between 1970 and 2016 toward higher life expectancy, most noticeably at higher levels of SDI. Among countries with populations greater than 1 million in 2016, life expectancy at birth was highest for women in Japan, at 86.9 years (95% UI 86.7-87.2), and for men in Singapore, at 81.3 years (78.8-83.7) in 2016. Male life expectancy was generally lower than female life expectancy between 1970 and 2016, and the gap between male and female life expectancy increased with progression to higher levels of SDI. Some countries with exceptional health performance in 1990 in terms of the difference in observed to expected life expectancy at birth had slower progress on the same measure in 2016. Interpretation Globally, mortality rates have decreased across all age groups over the past five decades, with the largest improvements occurring among children younger than 5 years. However, at the national level, considerable heterogeneity remains in terms of both level and rate of changes in age-specific mortality; increases in mortality for certain age groups occurred in some locations. We found evidence that the absolute gap between countries in age-specific death rates has declined, although the relative gap for some age-sex groups increased. Countries that now lead in terms of having higher observed life expectancy than that expected on the basis of development alone, or locations that have either increased this advantage or rapidly decreased the deficit from expected levels, could provide insight into the means to accelerate progress in nations where progress has stalled., Bill & Melinda Gates Foundation, and the National Institute on Aging and the National Institute of Mental Health of the National Institutes of Health.
Published: 2017

15. Multicomponent Behavioural Intervention during Pregnancy to Reduce Home Exposure to Second-Hand Smoke: A Pilot Randomised Controlled Trial in Bangladesh and India.

Author: Satyanarayana VA, Jackson C, Siddiqi K, Dherani M, Parrott S, Li J, Huque R, Chandra PS, and Rahman A
Subjects: Humans, Female, Pregnancy, Bangladesh, India, Pilot Projects, Adult, Cotinine analysis, Young Adult, Saliva chemistry, Male, Behavior Therapy methods, Tobacco Smoke Pollution prevention & control
Abstract: Background: Pregnant women exposed to second-hand smoke (SHS) are at increased risk of poor birth outcomes. We piloted multicomponent behavioural intervention and trial methods in Bangalore, India, and Comilla, Bangladesh., Methods: A pilot individual randomised controlled trial with economic and process evaluation components was conducted. Non-tobacco-using pregnant women exposed to SHS were recruited from clinics and randomly allocated to intervention or control (educational leaflet) arms. The process evaluation captured feedback on the trial methods and intervention components. The economic component piloted a service use questionnaire. The primary outcome was saliva cotinine 3 months post-intervention., Results: Most pregnant women and many husbands engaged with the intervention and rated the components highly, although the cotinine report elicited some anxiety. Forty-eight (Comilla) and fifty-four (Bangalore) women were recruited. The retention at 3 months was 100% (Comilla) and 78% (Bangalore). Primary outcome data were available for 98% (Comilla) and 77% (Bangalore)., Conclusions: The multicomponent behavioural intervention was feasible to deliver and was acceptable to the interventionists, pregnant women, and husbands. With the intervention, it was possible to recruit, randomise, and retain pregnant women in Bangladesh and India. The cotinine data will inform sample size calculations for a future definitive trial.
Published: 2024
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16. A behaviour change intervention to reduce home exposure to second hand smoke during pregnancy in India and Bangladesh: a theory and evidence-based approach to development.

Author: Satyanarayana VA, Jackson C, Siddiqi K, Chandra PS, Huque R, Dherani M, Nasreen S, Murthy P, and Rahman A
Abstract: Background: Home exposure to secondhand smoke (SHS) is highly prevalent amongst pregnant women in low- and middle-income countries like India and Bangladesh. The literature on the efficacy of behaviour change interventions to reduce home exposure to SHS in pregnancy is scarce., Methods: We employed a theory and evidence-based approach to develop an intervention using pregnant women as agents of change for their husband's smoking behaviours at home. A systematic review of SHS behaviour change interventions led us to focus on developing a multicomponent intervention and informed selection of behaviour change techniques (BCTs) for review in a modified Delphi survey. The modified Delphi survey provided expert consensus on the most effective BCTs in reducing home exposure to SHS. Finally, a qualitative interview study provided context and detailed understanding of knowledge, attitudes and practices around SHS. This insight informed the content and delivery of the proposed intervention components., Results: The final intervention consisted of four components: a report on saliva cotinine levels of the pregnant woman, a picture booklet containing information about SHS and its impact on health as well strategies to negotiate a smoke-free home, a letter from the future baby to their father encouraging him to provide a smoke-free home, and automated voice reminder and motivational messages delivered to husbands on their mobile phone. Intervention delivery was in a single face-to-face session with a research assistant who explained the cotinine report, discussed key strategies for ensuring a smoke-free environment at home and practised with pregnant women how they would share the booklet and letter with their husband and supportive family members., Conclusion: A theory and evidence-based approach informed the development of a multicomponent behaviour change intervention, described here. The acceptability and feasibility of the intervention which was subsequently tested in a pilot RCT in India and Bangladesh will be published later.
Published: 2021
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17. Post-traumatic stress disorder and association with low birth weight in displaced population following conflict in Malakand division, Pakistan: a case control study.

Author: Rashid HU, Khan MN, Imtiaz A, Ullah N, Dherani M, and Rahman A
Subjects: Adult, Birth Weight, Case-Control Studies, Female, Humans, Infant, Newborn, Logistic Models, Pakistan epidemiology, Pregnancy, Pregnant People psychology, Risk Factors, Socioeconomic Factors, Young Adult, Armed Conflicts psychology, Infant, Low Birth Weight psychology, Refugees psychology, Stress Disorders, Post-Traumatic epidemiology
Abstract: Background: The northern part of the province of Khyber Pakhtunkhwa in Pakistan experienced armed conflict since September 2007 till the autumn of 2011. Conflict involved widespread insurgency activity and military intervention including in 2009 internally displacing the 2.5 million people of the valley of Swat to live in camps, with relatives, or in rented accommodation across the region for approximately 4 months. It was during this period the current study was conducted to determine whether Post-Traumatic Stress Disorder in pregnant women was independently associated with Low Birth Weight (LBW) in an area affected by conflict and militancy., Methods: A case control study was conducted in tertiary care hospitals of district Peshawar, Khyber Pakhtunkhwa. Two hundred twenty-five cases (neonates with birth weight < 2.5 kg) and 225 controls (neonates with birth weight of > 2.5 kg) were enrolled within 24 h of delivery. Post-Traumatic Stress Disorder was assessed through the MINI Neuropsychiatric Interview 5.0, a validated questionnaire along with the birth weight of the newborn. Maternal anthropometry, anemia and other sociodemographic details were also obtained during data collection. Data was analyzed using statistical package (STATA version 14). Logistic regression analysis of the association between LBW and all variables collected with a p-value of < 0.25 on uni-variate analysis were entered., Results: A total of 450 newborn and mother pairs participated in the study with 225 cases and 225 controls. On univariate analysis factors significantly associated with LBW include: less than 5 years of paternal schooling and PTSD. On logistic regression, PTSD was independently associated with low birth weight in the presence of other factors like maternal/paternal schooling, gravida, history of preterm, BMI of the mother and maternal anemia., Conclusion: PTSD was found to be independently associated with LBW. In light of the current findings and other similar literature, intervention programs should be considered for pregnant women exposed to traumatic events.
Published: 2020
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18. Evaluating feasibility and acceptability of a local psycho-educational intervention for pregnant women with common mental problems affected by armed conflict in Swat, Pakistan: A parallel randomized controlled feasibility trial.

Author: Khan MN, Dherani M, Chiumento A, Atif N, Bristow K, Sikander S, and Rahman A
Subjects: Adult, Community Health Workers, Cross-Sectional Studies, Feasibility Studies, Female, Humans, Pakistan, Pregnancy, Self Report, Young Adult, Armed Conflicts psychology, Help-Seeking Behavior, Patient Education as Topic methods, Pregnant People psychology
Abstract: Background: The current research was conducted in the Swat valley, where widespread conflict and militancy had been experienced prior to the field activities. The aim of this trial was to evaluate the feasibility and acceptability of a locally developed psycho-educational intervention., Methods: This mixed-methods study incorporated a quantitative and qualitative component. For the quantitative component, trial participants were identified from a cross-sectional study conducted in the earlier phase of the research, with Self-Reporting Questionnaire (SRQ) score of ≥9. Participants with suicidal ideation, severe mental or medical illness, recently given birth or living with another woman with an SRQ score of 9 or above were excluded. Participants fulfilling eligibility were randomized on a 1:1 allocation ratio using simple randomization to the psycho-educational intervention or routine care arm. The intervention arm received two psycho-educational sessions at their homes delivered by local community health worker from the study area. The primary outcome was help-seeking for psychological distress, measured by a semi-structured interview by a researcher blind to the allocation status at 2 months post-intervention. Secondary outcomes include psychological distress and social support measured by SRQ and Multidimensional Scale of Perceived Social Support (MSPSS), respectively, at 2 months post-intervention. Intervention acceptability was explored through in-depth interviews., Results: Local community health workers with no mental health experience successfully delivered the psycho-educational sessions in the community. The uptake of intervention was good and the intervention was taken well by the families and the community health workers. The outcome evaluation was not powered; however, more women sought assistance for their distress from their community health workers in the intervention arm, compared to women in the control arm., Conclusion: This trial showed good acceptance and feasible delivery of a locally developed psycho-educational intervention through community health workers following conflict, giving way for further adaptation and evaluation.
Published: 2017
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19. Behaviour change interventions to reduce second-hand smoke exposure at home in pregnant women - a systematic review and intervention appraisal.

Author: Dherani M, Zehra SN, Jackson C, Satyanaryana V, Huque R, Chandra P, Rahman A, and Siddiqi K
Subjects: Female, Humans, Maternal Exposure adverse effects, Pregnancy, Smoking psychology, Smoking Cessation psychology, Tobacco Smoke Pollution adverse effects, Behavior Therapy methods, Maternal Exposure prevention & control, Prenatal Care methods, Smoking Cessation methods, Tobacco Smoke Pollution prevention & control
Abstract: Background: Second-hand smoke (SHS) exposure during pregnancy is associated with poor pregnancy and foetal outcomes. Theory-based behaviour change interventions (BCI) have been used successfully to change smoking related behaviours and offer the potential to reduce exposure of SHS in pregnant women. Systematic reviews conducted so far do not evaluate the generalisability and scalability of interventions. The objectives of this review were to (1) report the BCIs for reduction in home exposure to SHS for pregnant women; and (2) critically appraise intervention-reporting, generalisability, feasibility and scalability of the BCIs employed., Methods: Standard methods following PRISMA guidelines were employed. Eight databases were searched from 2000 to 2015 in English. The studies included used BCIs on pregnant women to reduce their home SHS exposure by targeting husbands/partners. The Workgroup for Intervention Development and Evaluation Research (WIDER) guidelines were used to assess intervention reporting. Generalisability, feasibility and scalability were assessed against criteria described by Bonell and Milat., Results: Of 3479 papers identified, six studies met the inclusion criteria. These studies found that BCIs led to increased knowledge about SHS harms, reduction or husbands quitting smoking, and increased susceptibility and change in level of actions to reduce SHS at home. Two studies reported objective exposure measures, and one reported objective health outcomes. The studies partially followed WIDER guidelines for reporting, and none met all generalisability, feasibility and scalability criteria., Conclusions: There is a dearth of literature in this area and the quality of studies reviewed was moderate to low. The BCIs appear effective in reducing SHS, however, weak study methodology (self-reported exposure, lack of objective outcome assessment, short follow-up, absence of control group) preclude firm conclusion. Some components of the WIDER checklist were followed for BCI reporting, scalability and feasibility of the studies were not described. More rigorous studies using biochemical and clinical measures for exposures and health outcomes in varied study settings are required. Studies should report interventions in detail using WIDER checklist and assess them for generalisability, feasibility and scalability., Trial Registration: CRD40125026666.
Published: 2017
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20. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study.

Author: Shi T, McAllister DA, O'Brien KL, Simoes EAF, Madhi SA, Gessner BD, Polack FP, Balsells E, Acacio S, Aguayo C, Alassani I, Ali A, Antonio M, Awasthi S, Awori JO, Azziz-Baumgartner E, Baggett HC, Baillie VL, Balmaseda A, Barahona A, Basnet S, Bassat Q, Basualdo W, Bigogo G, Bont L, Breiman RF, Brooks WA, Broor S, Bruce N, Bruden D, Buchy P, Campbell S, Carosone-Link P, Chadha M, Chipeta J, Chou M, Clara W, Cohen C, de Cuellar E, Dang DA, Dash-Yandag B, Deloria-Knoll M, Dherani M, Eap T, Ebruke BE, Echavarria M, de Freitas Lázaro Emediato CC, Fasce RA, Feikin DR, Feng L, Gentile A, Gordon A, Goswami D, Goyet S, Groome M, Halasa N, Hirve S, Homaira N, Howie SRC, Jara J, Jroundi I, Kartasasmita CB, Khuri-Bulos N, Kotloff KL, Krishnan A, Libster R, Lopez O, Lucero MG, Lucion F, Lupisan SP, Marcone DN, McCracken JP, Mejia M, Moisi JC, Montgomery JM, Moore DP, Moraleda C, Moyes J, Munywoki P, Mutyara K, Nicol MP, Nokes DJ, Nymadawa P, da Costa Oliveira MT, Oshitani H, Pandey N, Paranhos-Baccalà G, Phillips LN, Picot VS, Rahman M, Rakoto-Andrianarivelo M, Rasmussen ZA, Rath BA, Robinson A, Romero C, Russomando G, Salimi V, Sawatwong P, Scheltema N, Schweiger B, Scott JAG, Seidenberg P, Shen K, Singleton R, Sotomayor V, Strand TA, Sutanto A, Sylla M, Tapia MD, Thamthitiwat S, Thomas ED, Tokarz R, Turner C, Venter M, Waicharoen S, Wang J, Watthanaworawit W, Yoshida LM, Yu H, Zar HJ, Campbell H, and Nair H
Subjects: Child, Preschool, Developing Countries, Global Health, Hospital Mortality, Humans, Incidence, Infant, Infant, Newborn, Risk Factors, Hospitalization statistics & numerical data, Models, Statistical, Respiratory Syncytial Viruses isolation & purification, Respiratory Tract Infections epidemiology
Abstract: Background: We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on RSV has yielded substantial new data from developing countries. With a considerably expanded dataset from a large international collaboration, we aimed to estimate the global incidence, hospital admission rate, and mortality from RSV-ALRI episodes in young children in 2015., Methods: We estimated the incidence and hospital admission rate of RSV-associated ALRI (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions from a systematic review of studies published between Jan 1, 1995, and Dec 31, 2016, and unpublished data from 76 high quality population-based studies. We estimated the RSV-ALRI incidence for 132 developing countries using a risk factor-based model and 2015 population estimates. We estimated the in-hospital RSV-ALRI mortality by combining in-hospital case fatality ratios with hospital admission estimates from hospital-based (published and unpublished) studies. We also estimated overall RSV-ALRI mortality by identifying studies reporting monthly data for ALRI mortality in the community and RSV activity., Findings: We estimated that globally in 2015, 33·1 million (uncertainty range [UR] 21·6-50·3) episodes of RSV-ALRI, resulted in about 3·2 million (2·7-3·8) hospital admissions, and 59 600 (48 000-74 500) in-hospital deaths in children younger than 5 years. In children younger than 6 months, 1·4 million (UR 1·2-1·7) hospital admissions, and 27 300 (UR 20 700-36 200) in-hospital deaths were due to RSV-ALRI. We also estimated that the overall RSV-ALRI mortality could be as high as 118 200 (UR 94 600-149 400). Incidence and mortality varied substantially from year to year in any given population., Interpretation: Globally, RSV is a common cause of childhood ALRI and a major cause of hospital admissions in young children, resulting in a substantial burden on health-care services. About 45% of hospital admissions and in-hospital deaths due to RSV-ALRI occur in children younger than 6 months. An effective maternal RSV vaccine or monoclonal antibody could have a substantial effect on disease burden in this age group., Funding: The Bill & Melinda Gates Foundation., (Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.)
Published: 2017
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21. Real-life effectiveness of 'improved' stoves and clean fuels in reducing PM 2.5 and CO: Systematic review and meta-analysis.

Author: Pope D, Bruce N, Dherani M, Jagoe K, and Rehfuess E
Subjects: Developing Countries, Environmental Exposure, Environmental Monitoring, Family Characteristics, Humans, Rural Population, Air Pollutants analysis, Air Pollution, Indoor analysis, Carbon Monoxide analysis, Cooking instrumentation, Particulate Matter analysis
Abstract: Background: 2.8 billion people cook with solid fuels, resulting in almost 3 million premature deaths from household air pollution (HAP). To date, no systematic assessment of impacts on HAP of 'improved' stove and clean fuel interventions has been conducted., Objective: This systematic review synthesizes evidence for changes in kitchen and personal PM 2.5 and carbon monoxide (CO) following introduction of 'improved' solid fuel stoves and cleaner fuels in low- and middle-income countries (LMIC)., Methods: Searches of published and unpublished literature were conducted through databases and specialist websites. Eligible studies reported mean (24 or 48h) small particulate matter (majority PM 2.5 ) and/or CO. Eligible interventions were solid fuel stoves (with/without chimneys, advanced combustion), clean fuels (liquefied petroleum gas, biogas, ethanol, electricity, solar) and mixed. Data extraction and quality appraisal were undertaken using standardized forms, and publication bias assessed. Baseline and post-intervention values and percentage changes were tabulated and weighted averages calculated. Meta-analyses of absolute changes in PM and CO were conducted., Results: Most of the 42 included studies (112 estimates) addressed solid fuel stoves. Large reductions in pooled kitchen PM 2.5 (ranging from 41% (29-50%) for advanced combustion stoves to 83% (64-94%) for ethanol stoves), and CO (ranging from 39% (11-55%) for solid fuel stoves without chimneys to 82% (75-95%) for ethanol stoves. Reductions in personal exposure of 55% (19-87%) and 52% (-7-69%) for PM 2.5 and CO respectively, were observed for solid fuel stoves with chimneys. For the majority of interventions, post-intervention kitchen PM 2.5 levels remained well above WHO air quality guideline (AQG) limit values, although most met the AQG limit value for CO. Subgroup and sensitivity analyses did not substantially alter findings; publication bias was evident for chimney stove interventions but this was restricted to before-and-after studies., Conclusions: In everyday use in LMIC, neither 'improved' solid fuel stoves nor clean fuels (probably due to neighbourhood contamination) achieve PM 2.5 concentrations close to 24-hour AQG limit values. Household energy policy should prioritise community-wide use of clean fuels., (Copyright © 2017. Published by Elsevier Ltd.)
Published: 2017
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22. "He Doesn't Listen to My Words at All, So I Don't Tell Him Anything"-A Qualitative Investigation on Exposure to Second Hand Smoke among Pregnant Women, Their Husbands and Family Members from Rural Bangladesh and Urban India.

Author: Jackson C, Huque R, Satyanarayana V, Nasreen S, Kaur M, Barua D, Bhowmik PN, Guha M, Dherani M, Rahman A, Siddiqi K, and Chandra PS
Subjects: Bangladesh, Female, Humans, India, Male, Pregnancy, Rural Population, Urban Population, Environmental Exposure, Pregnant People psychology, Spouses psychology, Tobacco Smoke Pollution analysis
Abstract: Second hand smoke (SHS) exposure during pregnancy is associated with poor pregnancy and fetal outcomes. To design interventions to reduce exposure, an in depth understanding of social and cultural factors of smoking behavior at home is important, especially in South Asia where SHS exposure is high. This study aimed to explore pregnant women's, their husbands' and other family members' knowledge, attitudes and practices regarding home SHS exposure. Semi-structured interviews were conducted with 33 participants in Comilla, Bangladesh and 31 in Bangalore, India (36 pregnant women, 18 husbands, and 10 family members). Data were analyzed using the Framework approach. Husbands smoked in various living areas inside the home, often in the presence of their pregnant wives. Most had never tried to stop smoking at home. Knowledge of the risks was generally poor. Most women had repeatedly asked their husband to smoke outside with little success and only few family members had reprimanded the husbands. Husbands who had stopped did so because of requests from children and their mother. Potential strategies to decrease SHS exposure at home were educating the husband about risks and supporting the pregnant women in negotiation. Interventions must also enlist family support to enhance the woman's self-efficacy., Competing Interests: The authors declare no conflicts of interest.
Published: 2016
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23. Contrasting cardiovascular mortality trends in Eastern Mediterranean populations: Contributions from risk factor changes and treatments.

Author: Critchley J, Capewell S, O'Flaherty M, Abu-Rmeileh N, Rastam S, Saidi O, Sözmen K, Shoaibi A, Husseini A, Fouad F, Ben Mansour N, Aissi W, Ben Romdhane H, Unal B, Bandosz P, Bennett K, Dherani M, Al Ali R, Maziak W, Arık H, Gerçeklioğlu G, Altun DU, Şimşek H, Doganay S, Demiral Y, Aslan Ö, Unwin N, Phillimore P, Achour N, Aissi W, Allani R, Arfa C, Abu-Kteish H, Abu-Rmeileh N, Al Ali R, Altun D, Ahmad B, Arık H, Aslan Ö, Beltaifa L, Ben Mansour N, Bennett K, Ben Romdhane H, Ben Salah N, Collins M, Critchley J, Capewell S, Dherani M, Demiral Y, Doganay S, Elias M, Ergör G, Fadhil I, Fouad F, Gerçeklioğlu G, Ghandour R, Göğen S, Husseini A, Jaber S, Kalaca S, Khatib R, Khatib R, Koudsie S, Kilic B, Lassoued O, Mason H, Maziak W, Mayaleh MA, Mikki N, Moukeh G, Flaherty MO, Phillimore P, Rastam S, Roglic G, Saidi O, Saatli G, Satman I, Shoaibi A, Şimşek H, Soulaiman N, Sözmen K, Tlili F, Unal B, Unwin N, Yardim N, and Zaman S
Subjects: Adult, Aged, Cardiovascular Diseases diagnosis, Female, Humans, Hypertension diagnosis, Hypertension mortality, Hypertension therapy, Male, Mediterranean Region epidemiology, Middle Aged, Mortality trends, Risk Factors, Smoking adverse effects, Smoking mortality, Smoking therapy, Syria epidemiology, Treatment Outcome, Tunisia epidemiology, Turkey epidemiology, Cardiovascular Diseases mortality, Cardiovascular Diseases therapy, Population Surveillance methods
Abstract: Background: Middle income countries are facing an epidemic of non-communicable diseases, especially coronary heart disease (CHD). We used a validated CHD mortality model (IMPACT) to explain recent trends in Tunisia, Syria, the occupied Palestinian territory (oPt) and Turkey., Methods: Data on populations, mortality, patient numbers, treatments and risk factor trends from national and local surveys in each country were collated over two time points (1995-97; 2006-09); integrated and analysed using the IMPACT model., Results: Risk factor trends: Smoking prevalence was high in men, persisting in Syria but decreasing in Tunisia, oPt and Turkey. BMI rose by 1-2 kg/m(2) and diabetes prevalence increased by 40%-50%. Mean systolic blood pressure and cholesterol levels increased in Tunisia and Syria. Mortality trends: Age-standardised CHD mortality rates rose by 20% in Tunisia and 62% in Syria. Much of this increase (79% and 72% respectively) was attributed to adverse trends in major risk factors, occurring despite some improvements in treatment uptake. CHD mortality rates fell by 17% in oPt and by 25% in Turkey, with risk factor changes accounting for around 46% and 30% of this reduction respectively. Increased uptake of community treatments (drug treatments for chronic angina, heart failure, hypertension and secondary prevention after a cardiac event) accounted for most of the remainder., Discussion: CHD death rates are rising in Tunisia and Syria, whilst oPt and Turkey demonstrate clear falls, reflecting improvements in major risk factors with contributions from medical treatments. However, smoking prevalence remains very high in men; obesity and diabetes levels are rising dramatically., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
Published: 2016
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24. Psychological distress and its associations with past events in pregnant women affected by armed conflict in Swat, Pakistan: a cross sectional study.

Author: Khan MN, Chiumento A, Dherani M, Bristow K, Sikander S, and Rahman A
Abstract: Background: The public health significance of maternal mental health is well established. Armed conflicts expose populations to events that could have long-term negative consequences for mental health of pregnant women and their children. This study explores the prevalence and associated risk factors for psychological distress of women during pregnancy, including exposure to past conflict-related potentially traumatic events, in a population exposed to armed conflict in the Swat region of Pakistan., Methods: A community-based cross-sectional survey of 349 pregnant women in two union councils in Swat was conducted. Psychological distress was measured using the Self-Reporting Questionnaire (SRQ). Conflict-related potentially traumatic events (PTEs) were measured through an adapted version of the Harvard Trauma Questionnaire. Information was also collected on major life events (Life Events Checklist), social support (Multidimensional Scale of Perceived Social Support), and demographic and socio-economic variables., Results: Prevalence of current psychological distress was 38.1 % (95 % CI: 33.1, 43.3). Psychological distress was significantly associated with three or more potentially traumatic events (PTEs) experienced during the conflict (OR = 2.62, 95 % CI: 1.22, 5.61); three or more major life events in the year following the conflict (OR = 3.25, 95 % CI: 1.82, 5.82) and inversely associated with family support (OR = 0.91, 95 % CI: 0.88, 0.95)., Conclusion: This is one of the first community based cross sectional surveys in Swat valley, Pakistan to assess the prevalence of psychological distress during pregnancy in an area affected by conflict. Over a third of women show evidence of significant psychological distress. Exposure to potentially traumatic events remained independently associated with psychological distress 1 year after conflict ended, suggesting that conflict exposure may have long-term impacts upon maternal mental health. Combining this with findings relating to the cumulative impact of major life-events, and the protective factor of family support highlights the importance of developing culturally appropriate psychological interventions accessible to pregnant women rebuilding their lives following conflict.
Published: 2015
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25. Does household use of biomass fuel cause lung cancer? A systematic review and evaluation of the evidence for the GBD 2010 study.

Author: Bruce N, Dherani M, Liu R, Hosgood HD 3rd, Sapkota A, Smith KR, Straif K, Lan Q, and Pope D
Subjects: Air Pollution, Indoor adverse effects, Female, Humans, Male, Wood, Biomass, Cooking, Energy-Generating Resources, Heating, Lung Neoplasms etiology
Abstract: Background: Around 2.4 billion people use traditional biomass fuels for household cooking or heating. In 2006, the International Agency for Research on Cancer (IARC) concluded emissions from household coal combustion are a Group 1 carcinogen, while those from biomass were categorised as 2A due to epidemiologic limitations. This review updates the epidemiologic evidence and provides risk estimates for the 2010 Global Burden of Disease study., Methods: Searches were conducted of 10 databases to July 2012 for studies of clinically diagnosed or pathologically confirmed lung cancer associated with household biomass use for cooking and/or heating., Findings: Fourteen eligible studies of biomass cooking or heating were identified: 13 had independent estimates (12 cooking only), all were case-control designs and provided 8221 cases and 11 342 controls. The ORs for lung cancer risk with biomass for cooking and/or heating were OR 1.17 (95% CI 1.01 to 1.37) overall, and 1.15 (95% CI 0.97 to 1.37) for cooking only. Publication bias was not detected, but more than half the studies did not explicitly describe a clean reference category. Sensitivity analyses restricted to studies with adequate adjustment and a clean reference category found ORs of 1.21 (95% CI 1.05 to 1.39) for men (two reports, compiling five studies) and 1.95 (95% CI 1.16 to 3.27) for women (five reports, compiling eight studies). Exposure-response evidence was seen for men, and higher risk for women in developing compared with developed countries, consistent with higher exposures in the former., Conclusions: There is now stronger evidence for biomass fuel use causing lung cancer, but future studies need better exposure assessment to strengthen exposure-response evidence., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
Published: 2015
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26. Millions dead: how do we know and what does it mean? Methods used in the comparative risk assessment of household air pollution.

Author: Smith KR, Bruce N, Balakrishnan K, Adair-Rohani H, Balmes J, Chafe Z, Dherani M, Hosgood HD, Mehta S, Pope D, and Rehfuess E
Subjects: Age Factors, Global Health, Humans, Quality-Adjusted Life Years, Risk Assessment, Risk Factors, Sex Factors, Smoking adverse effects, Tobacco Smoke Pollution adverse effects, Air Pollution, Indoor adverse effects, Air Pollution, Indoor statistics & numerical data, Cooking methods, Environmental Exposure adverse effects, Environmental Exposure statistics & numerical data
Abstract: In the Comparative Risk Assessment (CRA) done as part of the Global Burden of Disease project (GBD-2010), the global and regional burdens of household air pollution (HAP) due to the use of solid cookfuels, were estimated along with 60+ other risk factors. This article describes how the HAP CRA was framed; how global HAP exposures were modeled; how diseases were judged to have sufficient evidence for inclusion; and how meta-analyses and exposure-response modeling were done to estimate relative risks. We explore relationships with the other air pollution risk factors: ambient air pollution, smoking, and secondhand smoke. We conclude with sensitivity analyses to illustrate some of the major uncertainties and recommendations for future work. We estimate that in 2010 HAP was responsible for 3.9 million premature deaths and ∼4.8% of lost healthy life years (DALYs), ranking it highest among environmental risk factors examined and one of the major risk factors of any type globally.
Published: 2014
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27. UK health performance: findings of the Global Burden of Disease Study 2010.

Author: Murray CJ, Richards MA, Newton JN, Fenton KA, Anderson HR, Atkinson C, Bennett D, Bernabé E, Blencowe H, Bourne R, Braithwaite T, Brayne C, Bruce NG, Brugha TS, Burney P, Dherani M, Dolk H, Edmond K, Ezzati M, Flaxman AD, Fleming TD, Freedman G, Gunnell D, Hay RJ, Hutchings SJ, Ohno SL, Lozano R, Lyons RA, Marcenes W, Naghavi M, Newton CR, Pearce N, Pope D, Rushton L, Salomon JA, Shibuya K, Vos T, Wang H, Williams HC, Woolf AD, Lopez AD, and Davis A
Subjects: Adolescent, Adult, Aged, Benchmarking, Cause of Death, Child, Child, Preschool, Chronic Disease mortality, Cost of Illness, Persons with Disabilities statistics & numerical data, Female, Health Policy, Humans, Infant, Life Expectancy trends, Male, Middle Aged, Quality-Adjusted Life Years, United Kingdom, Young Adult, Health Status
Abstract: Background: The UK has had universal free health care and public health programmes for more than six decades. Several policy initiatives and structural reforms of the health system have been undertaken. Health expenditure has increased substantially since 1990, albeit from relatively low levels compared with other countries. We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) to examine the patterns of health loss in the UK, the leading preventable risks that explain some of these patterns, and how UK outcomes compare with a set of comparable countries in the European Union and elsewhere in 1990 and 2010., Methods: We used results of GBD 2010 for 1990 and 2010 for the UK and 18 other comparator nations (the original 15 members of the European Union, Australia, Canada, Norway, and the USA; henceforth EU15+). We present analyses of trends and relative performance for mortality, causes of death, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE). We present results for 259 diseases and injuries and for 67 risk factors or clusters of risk factors relevant to the UK. We assessed the UK's rank for age-standardised YLLs and DALYs for their leading causes compared with EU15+ in 1990 and 2010. We estimated 95% uncertainty intervals (UIs) for all measures., Findings: For both mortality and disability, overall health has improved substantially in absolute terms in the UK from 1990 to 2010. Life expectancy in the UK increased by 4·2 years (95% UI 4·2-4·3) from 1990 to 2010. However, the UK performed significantly worse than the EU15+ for age-standardised death rates, age-standardised YLL rates, and life expectancy in 1990, and its relative position had worsened by 2010. Although in most age groups, there have been reductions in age-specific mortality, for men aged 30-34 years, mortality rates have hardly changed (reduction of 3·7%, 95% UI 2·7-4·9). In terms of premature mortality, worsening ranks are most notable for men and women aged 20-54 years. For all age groups, the contributions of Alzheimer's disease (increase of 137%, 16-277), cirrhosis (65%, ?15 to 107), and drug use disorders (577%, 71-942) to premature mortality rose from 1990 to 2010. In 2010, compared with EU15+, the UK had significantly lower rates of age-standardised YLLs for road injury, diabetes, liver cancer, and chronic kidney disease, but significantly greater rates for ischaemic heart disease, chronic obstructive pulmonary disease, lower respiratory infections, breast cancer, other cardiovascular and circulatory disorders, oesophageal cancer, preterm birth complications, congenital anomalies, and aortic aneurysm. Because YLDs per person by age and sex have not changed substantially from 1990 to 2010 but age-specific mortality has been falling, the importance of chronic disability is rising. The major causes of YLDs in 2010 were mental and behavioural disorders (including substance abuse; 21·5% [95 UI 17·2-26·3] of YLDs), and musculoskeletal disorders (30·5% [25·5-35·7]). The leading risk factor in the UK was tobacco (11·8% [10·5-13·3] of DALYs), followed by increased blood pressure (9·0 % [7·5-10·5]), and high body-mass index (8·6% [7·4-9·8]). Diet and physical inactivity accounted for 14·3% (95% UI 12·8-15·9) of UK DALYs in 2010., Interpretation: The performance of the UK in terms of premature mortality is persistently and significantly below the mean of EU15+ and requires additional concerted action. Further progress in premature mortality from several major causes, such as cardiovascular diseases and cancers, will probably require improved public health, prevention, early intervention, and treatment activities. The growing burden of disability, particularly from mental disorders, substance use, musculoskeletal disorders, and falls deserves an integrated and strategic response., Funding: Bill & Melinda Gates Foundation., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
Published: 2013
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28. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.

Author: Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fèvre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Franklin R, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gosselin R, Grainger R, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Ma J, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA 3rd, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Leòn FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, Murray CJ, AlMazroa MA, and Memish ZA
Subjects: Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Prevalence, Sex Factors, Young Adult, Global Health statistics & numerical data, Health Status, Quality-Adjusted Life Years, Wounds and Injuries epidemiology
Abstract: Background: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs)., Methods: Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis., Findings: Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350,000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient -0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa., Interpretation: Rates of YLDs per 100,000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world., Funding: Bill & Melinda Gates Foundation., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
Published: 2012
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29. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.

Author: Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, Amann M, Anderson HR, Andrews KG, Aryee M, Atkinson C, Bacchus LJ, Bahalim AN, Balakrishnan K, Balmes J, Barker-Collo S, Baxter A, Bell ML, Blore JD, Blyth F, Bonner C, Borges G, Bourne R, Boussinesq M, Brauer M, Brooks P, Bruce NG, Brunekreef B, Bryan-Hancock C, Bucello C, Buchbinder R, Bull F, Burnett RT, Byers TE, Calabria B, Carapetis J, Carnahan E, Chafe Z, Charlson F, Chen H, Chen JS, Cheng AT, Child JC, Cohen A, Colson KE, Cowie BC, Darby S, Darling S, Davis A, Degenhardt L, Dentener F, Des Jarlais DC, Devries K, Dherani M, Ding EL, Dorsey ER, Driscoll T, Edmond K, Ali SE, Engell RE, Erwin PJ, Fahimi S, Falder G, Farzadfar F, Ferrari A, Finucane MM, Flaxman S, Fowkes FG, Freedman G, Freeman MK, Gakidou E, Ghosh S, Giovannucci E, Gmel G, Graham K, Grainger R, Grant B, Gunnell D, Gutierrez HR, Hall W, Hoek HW, Hogan A, Hosgood HD 3rd, Hoy D, Hu H, Hubbell BJ, Hutchings SJ, Ibeanusi SE, Jacklyn GL, Jasrasaria R, Jonas JB, Kan H, Kanis JA, Kassebaum N, Kawakami N, Khang YH, Khatibzadeh S, Khoo JP, Kok C, Laden F, Lalloo R, Lan Q, Lathlean T, Leasher JL, Leigh J, Li Y, Lin JK, Lipshultz SE, London S, Lozano R, Lu Y, Mak J, Malekzadeh R, Mallinger L, Marcenes W, March L, Marks R, Martin R, McGale P, McGrath J, Mehta S, Mensah GA, Merriman TR, Micha R, Michaud C, Mishra V, Mohd Hanafiah K, Mokdad AA, Morawska L, Mozaffarian D, Murphy T, Naghavi M, Neal B, Nelson PK, Nolla JM, Norman R, Olives C, Omer SB, Orchard J, Osborne R, Ostro B, Page A, Pandey KD, Parry CD, Passmore E, Patra J, Pearce N, Pelizzari PM, Petzold M, Phillips MR, Pope D, Pope CA 3rd, Powles J, Rao M, Razavi H, Rehfuess EA, Rehm JT, Ritz B, Rivara FP, Roberts T, Robinson C, Rodriguez-Portales JA, Romieu I, Room R, Rosenfeld LC, Roy A, Rushton L, Salomon JA, Sampson U, Sanchez-Riera L, Sanman E, Sapkota A, Seedat S, Shi P, Shield K, Shivakoti R, Singh GM, Sleet DA, Smith E, Smith KR, Stapelberg NJ, Steenland K, Stöckl H, Stovner LJ, Straif K, Straney L, Thurston GD, Tran JH, Van Dingenen R, van Donkelaar A, Veerman JL, Vijayakumar L, Weintraub R, Weissman MM, White RA, Whiteford H, Wiersma ST, Wilkinson JD, Williams HC, Williams W, Wilson N, Woolf AD, Yip P, Zielinski JM, Lopez AD, Murray CJ, Ezzati M, AlMazroa MA, and Memish ZA
Subjects: Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Mortality, Quality-Adjusted Life Years, Risk Assessment methods, Risk Factors, Sex Factors, Young Adult, Global Health
Abstract: Background: Quantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a disease-by-disease analysis. No complete revision of global disease burden caused by risk factors has been done since a comparative risk assessment in 2000, and no previous analysis has assessed changes in burden attributable to risk factors over time., Methods: We estimated deaths and disability-adjusted life years (DALYs; sum of years lived with disability [YLD] and years of life lost [YLL]) attributable to the independent effects of 67 risk factors and clusters of risk factors for 21 regions in 1990 and 2010. We estimated exposure distributions for each year, region, sex, and age group, and relative risks per unit of exposure by systematically reviewing and synthesising published and unpublished data. We used these estimates, together with estimates of cause-specific deaths and DALYs from the Global Burden of Disease Study 2010, to calculate the burden attributable to each risk factor exposure compared with the theoretical-minimum-risk exposure. We incorporated uncertainty in disease burden, relative risks, and exposures into our estimates of attributable burden., Findings: In 2010, the three leading risk factors for global disease burden were high blood pressure (7·0% [95% uncertainty interval 6·2-7·7] of global DALYs), tobacco smoking including second-hand smoke (6·3% [5·5-7·0]), and alcohol use (5·5% [5·0-5·9]). In 1990, the leading risks were childhood underweight (7·9% [6·8-9·4]), household air pollution from solid fuels (HAP; 7·0% [5·6-8·3]), and tobacco smoking including second-hand smoke (6·1% [5·4-6·8]). Dietary risk factors and physical inactivity collectively accounted for 10·0% (95% UI 9·2-10·8) of global DALYs in 2010, with the most prominent dietary risks being diets low in fruits and those high in sodium. Several risks that primarily affect childhood communicable diseases, including unimproved water and sanitation and childhood micronutrient deficiencies, fell in rank between 1990 and 2010, with unimproved water and sanitation accounting for 0·9% (0·4-1·6) of global DALYs in 2010. However, in most of sub-Saharan Africa childhood underweight, HAP, and non-exclusive and discontinued breastfeeding were the leading risks in 2010, while HAP was the leading risk in south Asia. The leading risk factor in Eastern Europe, most of Latin America, and southern sub-Saharan Africa in 2010 was alcohol use; in most of Asia, North Africa and Middle East, and central Europe it was high blood pressure. Despite declines, tobacco smoking including second-hand smoke remained the leading risk in high-income north America and western Europe. High body-mass index has increased globally and it is the leading risk in Australasia and southern Latin America, and also ranks high in other high-income regions, North Africa and Middle East, and Oceania., Interpretation: Worldwide, the contribution of different risk factors to disease burden has changed substantially, with a shift away from risks for communicable diseases in children towards those for non-communicable diseases in adults. These changes are related to the ageing population, decreased mortality among children younger than 5 years, changes in cause-of-death composition, and changes in risk factor exposures. New evidence has led to changes in the magnitude of key risks including unimproved water and sanitation, vitamin A and zinc deficiencies, and ambient particulate matter pollution. The extent to which the epidemiological shift has occurred and what the leading risks currently are varies greatly across regions. In much of sub-Saharan Africa, the leading risks are still those associated with poverty and those that affect children., Funding: Bill & Melinda Gates Foundation., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
Published: 2012
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30. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.

Author: Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fèvre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Laden F, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Levinson D, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mock C, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA 3rd, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Leòn FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiebe N, Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, AlMazroa MA, and Memish ZA
Subjects: Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Prevalence, Sex Factors, Young Adult, Global Health statistics & numerical data, Health Status, Quality-Adjusted Life Years, Wounds and Injuries epidemiology
Abstract: Background: Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time., Methods: We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were calculated as prevalence of 1160 disabling sequelae, by age, sex, and cause, and weighted by new disability weights for each health state. Neither YLLs nor YLDs were age-weighted or discounted. Uncertainty around cause-specific DALYs was calculated incorporating uncertainty in levels of all-cause mortality, cause-specific mortality, prevalence, and disability weights., Findings: Global DALYs remained stable from 1990 (2·503 billion) to 2010 (2·490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income North America, and Australasia), rising to over 80% of DALYs in sub-Saharan Africa. In 1990, 47% of DALYs worldwide were from communicable, maternal, neonatal, and nutritional disorders, 43% from non-communicable diseases, and 10% from injuries. By 2010, this had shifted to 35%, 54%, and 11%, respectively. Ischaemic heart disease was the leading cause of DALYs worldwide in 2010 (up from fourth rank in 1990, increasing by 29%), followed by lower respiratory infections (top rank in 1990; 44% decline in DALYs), stroke (fifth in 1990; 19% increase), diarrhoeal diseases (second in 1990; 51% decrease), and HIV/AIDS (33rd in 1990; 351% increase). Major depressive disorder increased from 15th to 11th rank (37% increase) and road injury from 12th to 10th rank (34% increase). Substantial heterogeneity exists in rankings of leading causes of disease burden among regions., Interpretation: Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account. Because of improved definitions, methods, and data, these results for 1990 and 2010 supersede all previously published Global Burden of Disease results., Funding: Bill & Melinda Gates Foundation., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
Published: 2012
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31. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis.

Author: Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, O'Brien KL, Roca A, Wright PF, Bruce N, Chandran A, Theodoratou E, Sutanto A, Sedyaningsih ER, Ngama M, Munywoki PK, Kartasasmita C, Simões EA, Rudan I, Weber MW, and Campbell H
Subjects: Age Distribution, Ambulatory Care Facilities, Child, Preschool, Developed Countries, Developing Countries, Global Health, Hospitalization, Humans, Incidence, Infant, Infant, Newborn, Severity of Illness Index, Respiratory Syncytial Virus Infections epidemiology
Abstract: Background: The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005., Methods: We estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality., Findings: In 2005, an estimated 33.8 (95% CI 19.3-46.2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3.4 (2.8-4.3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000-199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting., Interpretation: Globally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority., Funding: WHO; Bill & Melinda Gates Foundation., (Copyright 2010 Elsevier Ltd. All rights reserved.)
Published: 2010
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32. Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population.

Author: Dherani M, Murthy GV, Gupta SK, Young IS, Maraini G, Camparini M, Price GM, John N, Chakravarthy U, and Fletcher AE
Subjects: Aged, Body Constitution, Cataract diagnosis, Cataract ethnology, Chromatography, High Pressure Liquid, Cross-Sectional Studies, Female, Humans, India epidemiology, Male, Middle Aged, Odds Ratio, Photography, Risk Factors, Rural Population statistics & numerical data, Surveys and Questionnaires, Ascorbic Acid blood, Carotenoids blood, Cataract blood, Vitamin A blood
Abstract: Purpose: To examine the association of blood antioxidants with cataract., Methods: Cross-sectional study of people aged >or=50 years identified from a household enumeration of 11 randomly sampled villages in North India. Participants were interviewed for putative risk factors (tobacco, alcohol, biomass fuel use, sunlight exposure, and socioeconomic status) and underwent lens photography and blood sampling. Lens photographs (nuclear, cortical, and posterior subcapsular) were graded according to the Lens Opacities Classification System (LOCS II). Cataract was defined as LOCS II grade >or=2 for any opacity or ungradable, because of dense opacification or history of cataract surgery. People without cataract were defined as LOCS II <2 on all three types of opacity, with absence of previous surgery., Results: Of 1443 people aged >or=50 years, 94% were interviewed, 87% attended an eye examination, and 78% gave a blood sample; 1112 (77%) were included in the analyses. Compared with levels in Western populations, antioxidants were low, especially vitamin C. Vitamin C was inversely associated with cataract. Odds ratios (OR) for the highest (>or=15 micromol/L) compared with the lowest (
Published: 2008
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33. Prevalence of early and late age-related macular degeneration in a rural population in northern India: the INDEYE feasibility study.

Author: Gupta SK, Murthy GV, Morrison N, Price GM, Dherani M, John N, Fletcher AE, and Chakravarthy U
Subjects: Age Distribution, Aged, Feasibility Studies, Female, Humans, India epidemiology, Macular Degeneration classification, Male, Middle Aged, Photography, Pilot Projects, Prevalence, Risk Factors, Sex Distribution, Macular Degeneration epidemiology, Rural Population statistics & numerical data
Abstract: Purpose: To assess the prevalence of age-related macular degeneration (AMD) in a rural population in Northern India., Methods: In a pilot feasibility study, 1443 people (median age, 60 years; 52% women), were identified from enumeration of the 50+ age group in 11 randomly sampled villages from a rural, periurban district of Haryana, Northern India. Of those identified, 87% attended an eye examination that included digital fundus photography. Fundus images were graded at a single reading center using definitions from the Wisconsin Age-Related Maculopathy Grading System., Results: Fundus photographs were available for 1101 participants. Overall, 28.8% of participants had ungradable fundus images due to cataract. Including all with ungradable images in the denominator, the prevalence of soft drusen was 34.0% (95% confidence interval [CI] 26.1-42.9); of soft indistinct drusen, 2.2% (95% CI, 1.1-4.4); and of pigmentary irregularities, 10.8% (95% CI, 7.1-16.1). There were 15 (1.4%) cases of late-stage AMD (95% CI, 0.8-2.3) with the prevalence rising from 0.4% in the 50- to 59-year age range to 4.6% in those aged 70 years or older., Conclusions: Drusen and pigmentary irregularities are common among the rural northern Indian population. The prevalence of late AMD is similar to that encountered in Western settings and is likely to contribute significantly to the burden of vision loss in older people in the developing world.
Published: 2007
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34. Prevalence of lens opacities in North India: the INDEYE feasibility study.

Author: Murthy GV, Gupta SK, Maraini G, Camparini M, Price GM, Dherani M, John N, Chakravarthy U, and Fletcher AE
Subjects: Aged, Cataract diagnosis, Feasibility Studies, Female, Humans, India epidemiology, Male, Middle Aged, Photography, Prevalence, Rural Population statistics & numerical data, Cataract epidemiology
Abstract: Purpose: To obtain estimates of the prevalence of lens opacities in an Indian setting by using photographically acquired lens images., Methods: In 11 randomly sampled villages from a rural district of Haryana, North India, 1443 people (median age 60 years), 52% women, were identified from enumeration of the > or =50-year age group; 87% attended an eye examination. Digital images of cortical and posterior subcapsular opacities and photographs of nuclear opacities were graded using the Lens Opacity Classification System (LOCS) II. The prevalence of opacities was based on a grade of 2 or higher in the worse eye for nuclear, cortical, or posterior subcapsular opacities., Results: Of the participants, 1071 people had gradable images; a further 163 had undergone surgery or had dense opacities. Nuclear opacities were the most common type, with an overall prevalence of 56.9% (95% CI, 53.0-60.6). Posterior subcapsular opacities occurred in 20.6% (95% CI, 17.9-25.8) and cortical opacities in 21.6% (95% CI, 17.9-25.8). Prevalence rose steeply with age for all opacities and was higher in the women than in the men for cortical opacities (P = 0.03). The prevalence of any type of lens opacity including surgical cases and dense opacities was 75.3% (95% CI, 71.4-78.81)., Conclusions: These results highlight the substantial excess of lens opacities in India compared with Western populations.
Published: 2007
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34 results on '"Dherani M"'

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2. Ramadan and eye-drops: perspective of Muslims in the UK

3. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

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14. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016

15. Multicomponent Behavioural Intervention during Pregnancy to Reduce Home Exposure to Second-Hand Smoke: A Pilot Randomised Controlled Trial in Bangladesh and India.

16. A behaviour change intervention to reduce home exposure to second hand smoke during pregnancy in India and Bangladesh: a theory and evidence-based approach to development.

17. Post-traumatic stress disorder and association with low birth weight in displaced population following conflict in Malakand division, Pakistan: a case control study.

18. Evaluating feasibility and acceptability of a local psycho-educational intervention for pregnant women with common mental problems affected by armed conflict in Swat, Pakistan: A parallel randomized controlled feasibility trial.

19. Behaviour change interventions to reduce second-hand smoke exposure at home in pregnant women - a systematic review and intervention appraisal.

20. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study.

21. Real-life effectiveness of 'improved' stoves and clean fuels in reducing PM 2.5 and CO: Systematic review and meta-analysis.

22. "He Doesn't Listen to My Words at All, So I Don't Tell Him Anything"-A Qualitative Investigation on Exposure to Second Hand Smoke among Pregnant Women, Their Husbands and Family Members from Rural Bangladesh and Urban India.

23. Contrasting cardiovascular mortality trends in Eastern Mediterranean populations: Contributions from risk factor changes and treatments.

24. Psychological distress and its associations with past events in pregnant women affected by armed conflict in Swat, Pakistan: a cross sectional study.

25. Does household use of biomass fuel cause lung cancer? A systematic review and evaluation of the evidence for the GBD 2010 study.

26. Millions dead: how do we know and what does it mean? Methods used in the comparative risk assessment of household air pollution.

27. UK health performance: findings of the Global Burden of Disease Study 2010.

28. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.

29. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.

30. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.

31. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis.

32. Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population.

33. Prevalence of early and late age-related macular degeneration in a rural population in northern India: the INDEYE feasibility study.

34. Prevalence of lens opacities in North India: the INDEYE feasibility study.

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