1. Use and Outcomes of Antiretroviral Monotherapy and Treatment Interruption in Adolescents With Perinatal HIV Infection in Asia
- Author
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P. Mohamad, Kulkanya Chokephaibulkit, Dina Muktiarti, Q. T. Du, V.C. Do, Suvaporn Anugulruengkit, I.B. Ramajaya, K. Chokephaibulkit, Keswadee Lapphra, M. Lim, Wanatpreeya Phongsamart, N. Kumarasamy, F. Daut, P. Lumbiganon, K.H. Truong, P. Kosalaraksa, Dewi Kumara Wati, M.R. Drawis, O. N. Le, P. Tharnprisan, Adam W. Bartlett, A. Kongphonoi, N. Kurniati, R. Nadsasarn, Nia Kurniati, T. M. Ha, R. Nallusamy, Chuenkamol Sethaputra, Thanyawee Puthanakit, Rawiwan Hansudewechakul, Pradthana Ounchanum, L. V. Nguyen, Sirintip Sricharoenchai, Revathy Nallusamy, S. Denjanta, T. Puthanakit, V. T. An, Penh Sun Ly, Annette H. Sohn, T. Sudjaritruk, Moy Siew Fong, Virat Sirisanthana, Joseph D. Tucker, T. Udomphanit, D. Vedaswari, P. S. Ly, L. T. Nguyen, Nik Khairuddin Nik Yusoff, R. Hansudewechakul, Lam Van Nguyen, Gonzague Jourdain, Nagalingeswaran Kumarasamy, S. M. Fong, J.L. Ross, D. T. K. Khu, Azar Kariminia, M.G. Law, Dewi K. Watu, Watsamon Jantarabenjakul, Nik Khairulddin Nik Yusoff, Pagakrong Lumbiganon, Viet Chau Do, Khanh Huu Truong, Vohith Khol, Tavitiya Sudjaritruk, A. H. Sohn, T.J. Mohamed, A. N. Pham, Thahira Jamal Mohamed, Linda Aurpibul, K. C. Chan, Ezhilarasi Chandrasekaran, Matthew Law, and C. H. Nguyen
- Subjects
Adult ,Pediatrics ,medicine.medical_specialty ,Asia ,Combination therapy ,Adolescent ,Anti-HIV Agents ,HIV Infections ,Emtricitabine ,Article ,Medication Adherence ,Cohort Studies ,03 medical and health sciences ,symbols.namesake ,Young Adult ,0302 clinical medicine ,Pharmacotherapy ,Pregnancy ,030225 pediatrics ,Antiretroviral Therapy, Highly Active ,medicine ,Humans ,030212 general & internal medicine ,Poisson regression ,Child ,business.industry ,Public Health, Environmental and Occupational Health ,Lamivudine ,Viral Load ,CD4 Lymphocyte Count ,Psychiatry and Mental health ,Tolerability ,Case-Control Studies ,Pediatrics, Perinatology and Child Health ,Cohort ,symbols ,Disease Progression ,Female ,business ,Viral load ,medicine.drug - Abstract
PURPOSE: Antiretroviral monotherapy and treatment interruption are potential strategies for perinatally HIV-infected adolescents (PHIVA) who face challenges maintaining effective combination antiretroviral therapy (ART). We assessed the use and outcomes for adolescents receiving monotherapy or undergoing treatment interruption in a regional Asian cohort. METHODS: Regional Asian data (2001–2016) were analyzed to describe PHIVA who experienced ≥2 weeks of lamivudine or emtricitabine monotherapy or treatment interruption and trends in CD4 count and HIV viral load during and after episodes. Survival analyses were used for World Health Organization (WHO) stage III/IV clinical and immunologic event-free survival during monotherapy or treatment interruption, and a Poisson regression to determine factors associated with monotherapy or treatment interruption. RESULTS: Of 3,448 PHIVA, 84 (2.4%) experienced 94 monotherapy episodes, and 147 (4.3%) experienced 174 treatment interruptions. Monotherapy was associated with older age, HIV RNA >400 copies/mL, younger age at ART initiation, and exposure to ≥2 combination ART regimens. Treatment interruption was associated with CD4 count
- Published
- 2019