Back to Search
Start Over
Use and Outcomes of Antiretroviral Monotherapy and Treatment Interruption in Adolescents With Perinatal HIV Infection in Asia
- Publication Year :
- 2019
-
Abstract
- PURPOSE: Antiretroviral monotherapy and treatment interruption are potential strategies for perinatally HIV-infected adolescents (PHIVA) who face challenges maintaining effective combination antiretroviral therapy (ART). We assessed the use and outcomes for adolescents receiving monotherapy or undergoing treatment interruption in a regional Asian cohort. METHODS: Regional Asian data (2001–2016) were analyzed to describe PHIVA who experienced ≥2 weeks of lamivudine or emtricitabine monotherapy or treatment interruption and trends in CD4 count and HIV viral load during and after episodes. Survival analyses were used for World Health Organization (WHO) stage III/IV clinical and immunologic event-free survival during monotherapy or treatment interruption, and a Poisson regression to determine factors associated with monotherapy or treatment interruption. RESULTS: Of 3,448 PHIVA, 84 (2.4%) experienced 94 monotherapy episodes, and 147 (4.3%) experienced 174 treatment interruptions. Monotherapy was associated with older age, HIV RNA >400 copies/mL, younger age at ART initiation, and exposure to ≥2 combination ART regimens. Treatment interruption was associated with CD4 count
- Subjects :
- Adult
Pediatrics
medicine.medical_specialty
Asia
Combination therapy
Adolescent
Anti-HIV Agents
HIV Infections
Emtricitabine
Article
Medication Adherence
Cohort Studies
03 medical and health sciences
symbols.namesake
Young Adult
0302 clinical medicine
Pharmacotherapy
Pregnancy
030225 pediatrics
Antiretroviral Therapy, Highly Active
medicine
Humans
030212 general & internal medicine
Poisson regression
Child
business.industry
Public Health, Environmental and Occupational Health
Lamivudine
Viral Load
CD4 Lymphocyte Count
Psychiatry and Mental health
Tolerability
Case-Control Studies
Pediatrics, Perinatology and Child Health
Cohort
symbols
Disease Progression
Female
business
Viral load
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e7410328908e256967082f8fb8a6bd9d