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Your search keyword '"Dewan, Kalyan K."' showing total 29 results
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29 results on '"Dewan, Kalyan K."'

1. Modeling Immune Evasion and Vaccine Limitations by Targeted Nasopharyngeal Bordetella pertussis Inoculation in Mice

Author

Soumana, Illiassou Hamidou, Linz, Bodo, Dewan, Kalyan K., Sarr, Demba, Gestal, Monica C., Howard, Laura K., Caulfield, Amanda D., Rada, Balazs, and Harvill, Eric T.

Subjects
Pertussis vaccines -- Testing, Immune response -- Models -- Health aspects, Bordetella pertussis -- Models -- Care and treatment -- Development and progression, Health
Abstract

Less than a century ago, Bordetella pertussis was rampant worldwide, causing pertussis (whooping cough) that killed millions of persons every year, mostly infants and children (1). Whole-cell pertussis vaccines (wP), [...]

Published
2021
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2. Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis

Author

Ma, Longhuan, Caulfleld, Amanda, Dewan, Kalyan K., and Harvill, Eric T.

Subjects
Medical research, Medicine, Experimental, Pertussis vaccines -- Research, Antigens -- Health aspects, Bordetella pertussis -- Genetic aspects, Membrane proteins -- Health aspects, Whooping-cough -- Prevention -- Care and treatment, Health
Abstract

Bordetella pertussis, the causative agent of pertussis (whooping cough), continues to reemerge in countries that have high vaccine coverage, such as the United States, and has accelerated since the switch [...]

Published
2021
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11. Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity

Author

Markley, Rachel L., primary, Restori, Katherine H., additional, Katkere, Bhuvana, additional, Sumner, Sarah E., additional, Nicol, McKayla J., additional, Tyryshkina, Anastasia, additional, Nettleford, Shaneice K., additional, Williamson, David R., additional, Place, David E., additional, Dewan, Kalyan K., additional, Shay, Ashley E., additional, Carlson, Bradley A., additional, Girirajan, Santhosh, additional, Prabhu, K. Sandeep, additional, and Kirimanjeswara, Girish S., additional

Published
2021
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17. Correction: A model of chronic, transmissible Otitis Media in mice

Author

Dewan, Kalyan K., primary, Taylor-Mulneix, Dawn L., additional, Campos, Laura L., additional, Skarlupka, Amanda L., additional, Wagner, Shannon M., additional, Ryman, Valerie E., additional, Gestal, Monica C., additional, Ma, Longhuan, additional, Blas-Machado, Uriel, additional, Faddis, Brian T., additional, and Harvill, Eric T., additional

Published
2019
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18. A model of chronic, transmissible Otitis Media in mice

Author

Dewan, Kalyan K., primary, Taylor-Mulneix, Dawn L., additional, Campos, Laura L., additional, Skarlupka, Amanda L., additional, Wagner, Shannon M., additional, Ryman, Valerie E., additional, Gestal, Monica C., additional, Ma, Longhua, additional, Blas-Machado, Uriel, additional, Faddis, Brian T., additional, and Harvill, Eric T., additional

Published
2019
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21. Development of macrolide resistance in Bordetella bronchiseptica is associated with the loss of virulence

Author

Dewan, Kalyan K, primary, Skarlupka, Amanda L, additional, Rivera, Israel, additional, Cuff, Laura E, additional, Gestal, Monica C, additional, Taylor-Mulneix, Dawn L, additional, Wagner, Shannon, additional, Ryman, Valerie E, additional, Rodriguez, Coralis, additional, Hamidou Soumana, Illiassou, additional, Levin, Bruce R, additional, and Harvill, Eric T, additional

Published
2018
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25. Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector

Author

Taylor-Mulneix, Dawn L., primary, Bendor, Liron, additional, Linz, Bodo, additional, Rivera, Israel, additional, Ryman, Valerie E., additional, Dewan, Kalyan K., additional, Wagner, Shannon M., additional, Wilson, Emily F., additional, Hilburger, Lindsay J., additional, Cuff, Laura E., additional, West, Christopher M., additional, and Harvill, Eric T., additional

Published
2017
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26. Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication

Author

Goralski, Tyler D. P., primary, Dewan, Kalyan K., additional, Alumasa, John N., additional, Avanzato, Victoria, additional, Place, David E., additional, Markley, Rachel L., additional, Katkere, Bhuvana, additional, Rabadi, Seham M., additional, Bakshi, Chandra Shekhar, additional, Keiler, Kenneth C., additional, and Kirimanjeswara, Girish S., additional

Published
2016
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27. Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication

Author

Goralski, Tyler D.P., primary, Dewan, Kalyan K., additional, Alumasa, John N., additional, Avanzato, Victoria, additional, Place, David E., additional, Markley, Rachel L., additional, Katkere, Bhuvana, additional, Rabadi, Seham M., additional, Bakshi, Chandra Shekhar, additional, Keiler, Kenneth C., additional, and Kirimanjeswara, Girish S., additional

Published
2016
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28. Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensisat All Stages of Intracellular Replication

Author

Goralski, Tyler D. P., Dewan, Kalyan K., Alumasa, John N., Avanzato, Victoria, Place, David E., Markley, Rachel L., Katkere, Bhuvana, Rabadi, Seham M., Bakshi, Chandra Shekhar, Keiler, Kenneth C., and Kirimanjeswara, Girish S.

Abstract

ABSTRACTBacteria require at least one pathway to rescue ribosomes stalled at the ends of mRNAs. The primary pathway for ribosome rescue is trans-translation, which is conserved in >99% of sequenced bacterial genomes. Some species also have backup systems, such as ArfA or ArfB, which can rescue ribosomes in the absence of sufficient trans-translation activity. Small-molecule inhibitors of ribosome rescue have broad-spectrum antimicrobial activity against bacteria grown in liquid culture. These compounds were tested against the tier 1 select agent Francisella tularensisto determine if they can limit bacterial proliferation during infection of eukaryotic cells. The inhibitors KKL-10 and KKL-40 exhibited exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensisin vitroand during ex vivoinfection. Addition of KKL-10 or KKL-40 to macrophages or liver cells at any time after infection by F. tularensisprevented further bacterial proliferation. When macrophages were stimulated with the proinflammatory cytokine gamma interferon before being infected by F. tularensis, addition of KKL-10 or KKL-40 reduced intracellular bacteria by >99%, indicating that the combination of cytokine-induced stress and a nonfunctional ribosome rescue pathway is fatal to F. tularensis. Neither KKL-10 nor KKL-40 was cytotoxic to eukaryotic cells in culture. These results demonstrate that ribosome rescue is required for F. tularensisgrowth at all stages of its infection cycle and suggest that KKL-10 and KKL-40 are good lead compounds for antibiotic development.

Published
2016
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