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2,363 results on '"Devred, A."'

3. Physical controls and ecological implications of the timing of the spring phytoplankton bloom on the Newfoundland and Labrador shelf

Author

Frédéric Cyr, Keith Lewis, David Bélanger, Paul Regular, Stephanie Clay, and Emmanuel Devred

Subjects
Oceanography, GC1-1581
Abstract

Abstract The timing of spring phytoplankton blooms is crucial to many species that have adapted their development to benefit from the enhanced feeding opportunity they offer. Any change to their timing may affect the productivity of an entire ecosystem. This study explores the relationship between the ocean climate, the timing of the spring bloom and the secondary production on the Newfoundland and Labrador shelf. It is found that over interannual cycles, the ocean climate is significantly correlated with the timing of the bloom and the abundance of Calanus finmarchicus, a key zooplankton species for the ecosystem. It also appears that the spring bloom is initiated by the onset of ocean re‐stratification following winter mixing. Understanding how annual variation in climate relates to the timing of the spring bloom and zooplankton abundance, that is, the base of the marine food web, can inform the development of ecosystem‐informed models for higher trophic levels.

Published
2024
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4. Optimizing the use of pressurized bladders for the assembly of HL-LHC MQXFB magnets

Author

Troitino, J. Ferradas, Ambrosio, G., Bourcey, N., Cheng, D., Devred, A., Felice, H., Ferracin, P., Guinchard, M., Bermudez, S. Izquierdo, Kandemir, K., Lusa, N., Milanese, A., Mugnier, S., Perez, J. C., Todesco, E., Triquet, S., and Vallone, G.

Subjects
Physics - Accelerator Physics
Abstract

The use of pressurized bladders for stress control of superconducting magnets was firstly proposed at Lawrence Berkeley National Laboratory (LBNL) in the early 2000s. Since then, the so-called bladders and keys procedure has become one of the reference techniques for the assembly of high-field accelerator magnets and demonstrators. Exploiting the advantages of this method is today of critical importance for Nb3Sn-based accelerator magnets, whose production requires the preservation of tight stress targets in the superconducting coils to limit the effects of the strain sensitivity and brittleness of the conductor. The present manuscript reports on the results of an experimental campaign focused on the optimization of the bladders and keys assembly process in the MQXFB quadrupoles. These 7.2 m long magnets shall be among the first Nb3Sn cryomagnets to be installed in a particle accelerator as a part of the High Luminosity upgrade of the LHC. One of the main practical implications of the bladders technique, especially important when applied to long magnets like MQXFB, is that to insert the loading keys, the opening of a certain clearance in the support structure is required. The procedure used so far for MQXF magnets involved an overstress in the coils during bladder inflation. The work presented here shows that such an overshoot can be eliminated thanks to additional bladders properly positioned in the structure. This optimized method was validated in a short model magnet and in a full-length mechanical model, becoming the new baseline for the series production at CERN. Furthermore, the results are supported by numerical predictions using Finite Element models.

Published
2023
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5. Challenges and Lessons Learned from fabrication, testing and analysis of eight MQXFA Low Beta Quadrupole magnets for HL-LHC

Author

Ambrosio, G., Amm, K., Anerella, M., Apollinari, G., Izquierdo, G. Arnau, Baldini, M., Ballarino, A., Barth, C., Yahia, A. Ben, Blowers, J., De Sousa, P. Borges, Bossert, R., Bulat, B., Carcagno, R., Cheng, D. W., Chlachidze, G., Cooley, L., Crouvizier, M., Devred, A., DiMarco, J., Feher, S., Ferracin, P., Troitino, J. Ferradas, Fajardo, L. Garcia, Gourlay, S., Hocker, H. M., Bermudez, S. Izquierdo, Joshi, P., Krave, S., Lee, E. M., Levitan, J., Lombardo, V., Lu, J., Marchevsky, M., Marinozzi, V., Moros, A., Muratore, J., Naus, M., Nobrega, F., Page, T., Pong, I., Perez, J. C., Prestemon, S., Ravaioli, E., Ray, K. L., Sabbi, G., Schmalzle, J., Seyl, J., Sgobba, S., Stoynev, S., Strauss, T., Todesco, E., Turrioni, D., Vallone, G., Van Weelderen, R., Wanderer, P., Wang, X., and Yu, M.

Subjects
Physics - Accelerator Physics
Abstract

By the end of October 2022, the US HL-LHC Accelerator Upgrade Project (AUP) had completed fabrication of ten MQXFA magnets and tested eight of them. The MQXFA magnets are the low beta quadrupole magnets to be used in the Q1 and Q3 Inner Triplet elements of the High Luminosity LHC. This AUP effort is shared by BNL, Fermilab, and LBNL, with strand verification tests at NHMFL. An important step of the AUP QA plan is the testing of MQXFA magnets in a vertical cryostat at BNL. The acceptance criteria that could be tested at BNL were all met by the first four production magnets (MQXFA03-MQXFA06). Subsequently, two magnets (MQXFA07 and MQXFA08) did not meet some criteria and were disassembled. Lessons learned during the disassembly of MQXFA07 caused a revision to the assembly specifications that were used for MQXFA10 and subsequent magnets. In this paper, we present a summary of: 1) the fabrication and test data of all the MQXFA magnets; 2) the analysis of MQXFA07/A08 test results with characterization of the limiting mechanism; 3) the outcome of the investigation, including the lessons learned during MQXFA07 disassembly; and 4) the finite element analysis correlating observations with test performance.

Published
2023
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6. 11T Dipole and New Connection Cryostats for Collimators

Author

Bordini, Bernardo, primary, Bottura, Luca, additional, Devred, Arnaud, additional, Fiscarelli, Lucio, additional, Karppinen, Mikko, additional, Rijk, Gijs de, additional, Rossi, Lucio, additional, Savary, Frédéric, additional, Schörling, Daniel, additional, and Willering, Gerard, additional

Published
2024
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7. A Metallurgical Inspection Method to Assess the Damage in Performance-Limiting Nb3Sn Accelerator Magnet Coils

Author

Moros, Alice, Crouvizier, Mickael Denis, Santillana, Ignacio Aviles, Sgobba, Stefano, Bermudez, Susana Izquierdo, Lusa, Nicholas, Troitino, Jose Ferradas, Milanese, Attilio, Todesco, Ezio, Devred, Arnaud, Ambrosio, Giorgio, Baldini, Maria, Ferracin, Paolo, Schmalzle, Jesse, and Vallone, Giorgio

Subjects
Physics - Accelerator Physics
Abstract

The design and production of Nb3Sn-based dipole and quadrupole magnets is critical for the realization of the High-Luminosity Large Hadron Collider (HL-LHC) at the European Organization for Nuclear Research (CERN). Nb3Sn superconducting coils are aimed at enhancing the bending and focusing strengths of accelerator magnets for HL-LHC and beyond. Due to the brittle nature of Nb3Sn, the coil fabrication steps are very challenging and require very careful QA/QC. Flaws in the Nb3Sn filaments may lead to quenches, and eventually, performance limitation below nominal during magnet testing. A novel inspection method, including advanced non-destructive and destructive techniques, was developed to explore the root-causes of quenches occurring in performance-limiting coils. The most relevant results obtained for MQXF coils through this innovative inspection method are presented. This approach allows for precise assessment of the physical events associated to the quenches experienced b y magnet coils, mainly occurring under the form of damaged strands with transversely broken sub-elements. Coil-slice preparation, micro-optical observations of transverse and longitudinal cross-sections, and a deep etching technique of copper will be illustrated in the present work, with a focus on the results achieved for a CERN coil from a non-conforming quadrupole magnet prototype, and two coils fabricated in the US, in the framework of the Accelerator Upgrade Project (AUP) collaboration, from two different non-conforming quadrupole magnets, respectively. The results obtained through the proposed inspection method will be illustrated., Comment: Applied Superconductivity Conference 2022

Published
2022
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8. Challenges and Lessons Learned From Fabrication, Testing, and Analysis of Eight MQXFA Low Beta Quadrupole Magnets for HL-LHC

Author

Ambrosio, Giorgio, Amm, Kathleen, Anerella, Michael, Apollinari, Giorgio, Izquierdo, Gonzalo Arnau, Baldini, Maria, Ballarino, Amalia, Barth, Christian, Yahia, Anis Ben, Blowers, James, De Sousa, P Borges, Bossert, R, Bulat, Bartosz Wojciech, Carcagno, Ruben H, Cheng, Daniel W, Chlachidze, G, Cooley, Lance, Crouvizier, Mickael, Devred, Arnaud, DiMarco, Joseph, Feher, Sandor, Ferracin, Paolo, Troitino, Jose Ferradas, Fajardo, Laura Garcia, Gourlay, S, Hocker, Henry M, Bermudez, Susana Izquierdo, Joshi, Piyush, Krave, Steven T, Lee, Elizabeth Marie, Levitan, Jeremy W, Lombardo, Vito, Lu, Jun, Marchevsky, Maxim, Marinozzi, Vittorio, Moros, Alice, Muratore, Joseph F, Naus, Michael, Nobrega, Alfred, Page, T, Pong, Ian, Perez, JC, Prestemon, Soren, Ray, Katherine L, Sabbi, GianLuca, Schmalzle, Jesse, Seyl, J, Sgobba, Stefano, Stoynev, S, Strauss, T, Todesco, Ezio, Turrioni, Daniele, Vallone, Giorgio, Van Weelderen, R, Wanderer, P, Wang, X, and Yu, Miao

Subjects
Nuclear and Plasma Physics, Physical Sciences, Accelerator magnets, HL-LHC, Nb3Sn, super-conducting magnets, ATAP-GENERAL, ATAP-SMP, ATAP-2023, Condensed Matter Physics, Electrical and Electronic Engineering, Materials Engineering, General Physics, Electrical engineering, Condensed matter physics
Abstract

By the end of October 2022, the US HL-LHC Accelerator Upgrade Project (AUP) had completed fabrication of ten MQXFA magnets and tested eight of them. The MQXFA magnets are the low-beta quadrupole magnets to be used in the Q1 and Q3 Inner Triplet elements of the High Luminosity LHC. This AUP effort is shared by BNL, Fermilab, and LBNL, with strand verification tests at NHMFL. An important step of the AUP QA plan is the testing of MQXFA magnets in a vertical cryostat at BNL. The acceptance criteria that could be tested at BNL were all met by the first four production magnets (MQXFA03-MQXFA06). Subsequently, two magnets (MQXFA07 and MQXFA08) did not meet some of the criteria and were disassembled. Lessons learned during the disassembly of MQXFA07 caused a revision to the assembly specifications that were used for MQXFA10 and subsequent magnets. In this article, we present a summary of: 1) the fabrication and test data for all the MQXFA magnets; 2) the analysis of MQXFA07/A08 test results with characterization of the limiting mechanism; 3) the outcome of the investigation, including the lessons learned during MQXFA07 disassembly; and 4) the finite element analysis correlating observations with test performance.

Published
2023

12. Incidence and risk factors of neonatal bacterial infections: a community-based cohort from Madagascar (2018–2021)

Author

Devred, Ines, Rambliere, Lison, Herindrainy, Perlinot, Andriamarohasina, Lovarivelo, Harimanana, Aina, Randrianirina, Frederique, Ratsima, Elisoa Hariniaina, Hivernaud, Delphine, Kermorvant-Duchemin, Elsa, Andrianirina, Zafitsara Zo, Abdou, Armya Youssouf, Delarocque-Astagneau, Elisabeth, Guillemot, Didier, Crucitti, Tania, Collard, Jean-Marc, and Huynh, Bich-Tram

Published
2023
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14. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trialsResearch in context

Author

Ilias I. Siempos, Andre C. Kalil, Drifa Belhadi, Viviane Cordeiro Veiga, Alexandre Biasi Cavalcanti, Westyn Branch-Elliman, Eleni Papoutsi, Konstantinos Gkirgkiris, Nikoleta A. Xixi, Anastasia Kotanidou, Olivier Hermine, Raphaël Porcher, Xavier Mariette, Philippe Ravaud, Serge Bureau, Maxime Dougados, Matthieu Resche-Rigon, Pierre-Louis Tharaux, Annick Tibi, Elie Azoulay, Jacques Cadranel, Joseph Emmerich, Muriel Fartoukh, Bertrand Guidet, Marc Humbert, Karine Lacombe, Matthieu Mahevas, Frédéric Pene, Valerie Pourchet-Martinez, Frédéric Schlemmer, Yazdan Yazdanpanah, Gabriel Baron, Elodie Perrodeau, Damien Vanhoye, Cécile Kedzia, Lauren Demerville, Anne Gysembergh-Houal, Alexandre Bourgoin, Nabil Raked, Lakhdar Mameri, Claire Montlahuc, Lucie Biard, St.phanie Alary, Samir Hamiria, Thinhinane Bariz, Hala Semri, Dhiaa Meriem Hai, Moustafa Benafla, Mohamed Belloul, Pernelle Vauboin, Saskia Flamand, Claire Pacheco, Anouk Walter-Petrich, Emilia Stan, Souad Benarab, Corine Nyanou, Robin Charreteur, Céline Dupre, Kévin Cardet, Blandine Lehmann, Kamyl Baghli, Claire Madelaine, Eric D'Ortenzio, Oriane Puéchal, Caroline Semaille, Laurent Savale, Anatole Harrois, Samy Figueiredo, Jacques Duranteau, Nadia Anguel, Arthur Pavot, Xavier Monnet, Christian Richard, Jean-Louis Teboul, Philippe Durand, Pierre Tissieres, Mitja Jevnikar, David Montani, Stephan Pavy, Gaétane Nocturne, Samuel Bitoun, Nicolas Noel, Olivier Lambotte, Lelia Escaut, Stephane Jauréguiberry, Elodie Baudry, Christiane Verny, Edouard Lefevre, Mohamad Zaidan, Domitille Molinari, Gaël Leprun, Alain Fourreau, Laurent Cylly, Lamiae Grimaldi, Myriam Virlouvet, Ramdane Meftali, Soléne Fabre, Marion Licois, Asmaa Mamoune, Yacine Boudali, Clotilde Le Tiec, Céline Verstuyft, Anne-Marie Roques, Sophie Georgin-Lavialle, Patricia Senet, Gilles Pialoux, Angele Soria, Antoine Parrot, Helene François, Nathalie Rozensztajn, Emmanuelle Blin, Pascaline Choinier, Juliette Camuset, Jean-Simon Rech, Antony Canellas, Camille Rolland-Debord, Nadege Lemarié, Nicolas Belaube, Marine Nadal, Martin Siguier, Camille Petit-Hoang, Julie Chas, Elodie Drouet, Matthieu Lemoine, Audrey Phibel, Lucie Aunay, Eliane Bertrand, Sylviane Ravato, Marie Vayssettes, Anne Adda, Celine Wilpotte, Pélagie Thibaut, Julie Fillon, Isabelle Debrix, Soraya Fellahi, Jean-Philippe Bastard, Guillaume Lefévre, Jacques-Eric Gottenberg, Yves Hansmann, Frédéric Blanc, Sophie Ohlmann-Caillard, Vincent Castelain, Emmanuel Chatelus, Eva Chatron, Olivier Collange, François Danion, Frédéric De Blay, Pierre Diemunsch, Sophie Diemunsch, Renaud Felten, Bernard Goichot, Valentin Greigert, Aurelien Guffroy, Bob Heger, Charlotte Kaeuffer, Loic Kassegne, Anne Sophie Korganow, Pierrick Le Borgne, Nicolas Lefebvre, Paul-Michel Mertes, Eric Noll, Mathieu Oberlin, Vincent Poindron, Julien Pottecher, Yvon Ruch, François Weill, Nicolas Meyer, Emmanuel Andres, Eric Demonsant, Hakim Tayebi, Gabriel Nisand, Stéphane Brin, Cédric Sublon, Guillaume Becker, Anne Hutt, Tristan Martin, Sophie Bayer, Catherine Metzger, Arsene Mekinian, Noémie Abisror, Amir Adedjouma, Diane Bollens, Marion Bonneton, Nathalie Bourcicaux, Anne Bourrier, Maria Chauchard Thibault Chiarabiani, Doroth.e Chopin, Jonathan Cohen, Ines Devred, Bruno Donadille, Olivier Fain, Geoffrey Hariri, Vincent Jachiet, Patrick Ingliz, Marc Garnier, Marc Gatfosse, Etienne Ghrenassia, Delphine Gobert, Jessica Krause le Garrec, Cecilia Landman, Jean Remy Lavillegrand, Benedicte Lefebvre, Thibault Mahevas, Sandie Mazerand, Jean Luc Meynard, Marjolaine Morgand, Zineb Ouaz.ne, Jerome Pacanowski, S.bastien Riviere, Philippe Seksik, Harry Sokol, Heithem Soliman, Nadia Valin, Thomas Urbina, Chloé McAvoy, Maria Pereira Miranda, Gladys Aratus, Laurence Berard, Tabassome Simon, Anne Daguenel Nguyen, Elise Girault, Cl.mentine Mayala-Kanda, Marie Antignac, Céline Leplay, Jean-Benoit Arlet, Jean-Luc Diehl, Florence Bellenfant, Anne Blanchard, Alexandre Buffet, Bernard Cholley, Antoine Fayol, Edouard Flamarion, Anne Godier, Thomas Gorget, Sophie-Rym Hamada, Caroline Hauw-Berlemont, Jean-Sébastien Hulot, David Lebeaux, Marine Livrozet, Adrien Michon, Arthur Neuschwander, Marie-Aude Pennet, Benjamin Planquette, Brigitte Ranque, Olivier Sanchez, Geoffroy Volle, Sandrine Briois, Mathias Cornic, Virginie Elisee, Jesuthasan Denis, Juliette Djadi-Prat, Pauline Jouany, Ramon Junquera, Mickael Henriques, Amina Kebir, Isabelle Lehir, Jeanne Meunier, Florence Patin, Val.rie Paquet, Anne Tréhan, Véronique Vigna, Brigitte Sabatier, Damien Bergerot, Charléne Jouve, Camille Knosp, Olivia Lenoir, Nassim Mahtal, Léa Resmini, Xavier Lescure, Jade Ghosn, Antoine Bachelard, Anne Rachline, Valentina Isernia, Bao-chau, Phung, Dorothée Vallois, Aurelie Sautereau, Catherine Neukrich, Antoine Dossier, Raphaël Borie, Bruno Crestani, Gregory Ducrocq, Philippe Gabriel Steg, Philippe Dieude, Thomas Papo, Estelle Marcault, Marhaba Chaudhry, Charléne Da Silveira, Annabelle Metois, Ismahan Mahenni, Meriam Meziani, Cyndie Nilusmas, Sylvie Le Gac, Awa Ndiaye, Fran.oise Louni, Malikhone Chansombat, Zelie Julia, Solaya Chalal, Lynda Chalal, Laura Kramer, Jeniffer Le Grand, Kafif Ouifiya, Valentine Piquard, Sarah Tubiana, Yann Nguyen, Vasco Honsel, Emmanuel Weiss, Anais Codorniu, Virginie Zarrouk, Victoire de Lastours, Matthieu Uzzan, Naura Gamany, Agathe Claveirole, Alexandre Navid, Tiffanie Fouque, Yonathan Cohen, Maya Lupo, Constance Gilles, Roza Rahli, Zeina Louis, David Boutboul, Lionel Galicier, Yaël Amara, Gabrielle Archer, Amira Benattia, Anne Bergeron, Louise Bondeelle, Nathalie de Castro, Melissa Clément, Michaël Darmon, Blandine Denis, Clairelyne Dupin, Elsa Feredj, Delphine Feyeux, Adrien Joseph, Etienne Lenglin, Pierre Le Guen, Geoffroy Liégeon, Gwenaël Lorillon, Asma Mabrouki, Eric Mariotte, Grégoire Martin de Frémont, Adrien Mirouse, Jean-Michel Molina, Régis Peffault de Latour, Eric Oksenhendler, Julien Saussereau, Abdellatif Tazi, Jean-Jacques Tudesq, Lara Zafrani, Isabelle Brindele, Emmanuelle Bugnet, Karine Celli Lebras, Julien Chabert, Lamia Djaghout, Catherine Fauvaux, Anne Lise Jegu, Ewa Kozakiewicz, Martine Meunier, Marie-Thérèse Tremorin, Claire Davoine, Isabelle Madelaine, Sophie Caillat-Zucman, Constance Delaugerre, Florence Morin, Damien Sène, Ruxandra Burlacu, Benjamin Chousterman, Bruno Mégarbanne, Pascal Richette, Jean-Pierre Riveline, Aline Frazier, Eric Vicaut, Laure Berton, Tassadit Hadjam, Miguel Alejandro Vazquez-Ibarra, Clément Jourdaine, Olivia Tran, Véronique Jouis, Aude Jacob, Julie Smati, Stéphane Renaud, Claire Pernin, Lydia Suarez, Luca Semerano, Sébastien Abad, Ruben B. nainous, Nicolas Bonnet, Celine Comparon, Yves Cohen, Hugues Cordel, Robin Dhote, Nathalie Dournon, Boris Duchemann, Nathan Ebstein, Thomas Gille, Benedicte Giroux-Leprieur, Jeanne Goupil de Bouille, Hilario Nunes, Johanna Oziel, Dominique Roulot, Lucile Sese, ClaireTantet, Yurdagul Uzunhan, Coralie Bloch-Queyrat, Vincent Levy, Fadhila Messani, Mohammed Rahaoui, Myléne Petit, Sabrina Brahmi, Vanessa Rathoin, Marthe Rigal, Nathalie Costedoat-Chalumeau, Liem Binh Luong, Zakaria Ait Hamou, Sarah Benghanem, Philippe Blanche, Nicolas Carlier, Benjamin Chaigne, Remy Gauzit, Hassan Joumaa, Mathieu Jozwiak, Marie Lachétre, Hélène Lafoeste, Odie Launay, Paul Legendre, Jonathan Marey, Caroline Morbieu, Lola-Jade Palmieri, Tali-Anne Szwebel, Hendy Abdoul, Alexandra Bruneau, Audrey Beclin-Clabaux, Charly Larrieu, Pierre Montanari, Eric Dufour, Ada Clarke, Catherine Le Bourlout, Nathalie Marin, Nathalie Menage, Samira Saleh-Mghir, Mamadou Salif Cisse, Kahina Cheref, Corinne Guerin, Jérémie Zerbit, Marc Michel, Sébastien Gallien, Etienne Crickx, Benjamin Le Vavasseur, Emmanuelle Kempf, Karim Jaffal, William Vindrios, Julie Oniszczuk, Constance Guillaud, Pascal Lim, Elena Fois, Giovanna Melica, Marie Matignon, Maud Jalabert, Jean-Daniel Lelièvre, David Schmitz, Marion Bourhis, Sylia Belazouz, Laetitia Languille, Caroline Boucle, Nelly Cita, Agnés Didier, Fahem Froura, Katia Ledudal, Thiziri Sadaoui, Alaki Thiemele, Delphine Le Febvre De Bailly, Muriel Carvhalo Verlinde, Julien Mayaux, Patrice Cacoub, David Saadoun, Mathieu Vautier, Héléne Bugaut, Olivier Benveniste, Yves Allenbach, Gaëlle Leroux, Aude Rigolet, Perrine Guillaume-Jugnot, Fanny Domont, Anne Claire Desbois, Chloé Comarmond, Nicolas Champtiaux, Segolene Toquet, Amine Ghembaza, Matheus Vieira, Georgina Maalouf, Goncalo Boleto, Yasmina Ferfar, Jean-Christophe Corvol, C.line Louapre, Sara Sambin, Louise-Laure Mariani, Carine Karachi, Florence Tubach, Candice Estellat, Linda Gimeno, Karine Martin, Aicha Bah, Vixra Keo, Sabrine Ouamri, Yasmine Messaoudi, Nessima Yelles, Pierre Faye, Sebastien Cavelot, Cecile Larcheveque, Laurence Annonay, Jaouad Benhida, Aida Zahrate-Ghoul, Soumeya Hammal, Ridha Belilita, Fanny Charbonnier, Claire Aguilar, Fanny Alby-Laurent, Carole Burger, Clara Campos-Vega, Nathalie Chavarot, Benjamin Fournier, Claire Rouzaud, Damien Vimpére, Caroline Elie, Prissile Bakouboula, Laure Choupeaux, Sophie Granville, Elodie Issorat, Christine Broissand, Marie-Alexandra Alyanakian, Guillaume Geri, Nawal Derridj, Naima Sguiouar, Hakim Meddah, Mourad Djadel, Héléne Chambrin-Lauvray, Jean-Charles Duclos-vallée, Faouzi Saliba, Sophie-Caroline Sacleux, Ilias Kounis, Sonia Tamazirt, Eric Rudant, Jean-Marie Michot, Annabelle Stoclin, Emeline Colomba, Fanny Pommeret, Christophe Willekens, Rosa Da Silva, Valérie Dejean, Yasmina Mekid, Ines Ben-Mabrouk, Florence Netzer, Caroline Pradon, Laurence Drouard, Valérie Camara-Clayette, Alexandre Morel, Gilles Garcia, Abolfazl Mohebbi, Férial Berbour, Mélanie Dehais, Anne-Lise Pouliquen, Alison Klasen, Loren Soyez-Herkert, Jonathan London, Younes Keroumi, Emmanuelle Guillot, Guillaume Grailles, Younes El amine, Fanny Defrancq, Hanane Fodil, Chaouki Bouras, Dominique Dautel, Nicolas Gambier, Thierno Dieye, Boris Bienvenu, Victor Lancon, Laurence Lecomte, Kristina Beziriganyan, Belkacem Asselate, Laure Allanic, Elena Kiouris, Marie-Héléne Legros, Christine Lemagner, Pascal Martel, Vincent Provitolo, Félix Ackermann, Mathilde Le Marchand, Aurélie Chan Hew Wai, Dimitri Fremont, Elisabeth Coupez, Mireille Adda, Frédéric Duée, Lise Bernard, Antoine Gros, Estelle Henry, Claire Courtin, Anne Pattyn, Pierre-Grégoire Guinot, Marc Bardou, Agnes Maurer, Julie Jambon, Amélie Cransac, Corinne Pernot, Bruno Mourvillier, Eric Marquis, Philippe Benoit, Damien Roux, Coralie Gernez, Cécile Yelnik, Julien Poissy, Mandy Nizard, Fanette Denies, Helene Gros, Jean-Jacques Mourad, Emmanuelle Sacco, Sophie Renet, F. Ader, Y. Yazdanpanah, F. Mentre, N. Peiffer-Smadja, F.X. Lescure, J. Poissy, L. Bouadma, J.F. Timsit, B. Lina, F. Morfin-Sherpa, M. Bouscambert, A. Gaymard, G. Peytavin, L. Abel, J. Guedj, C. Andrejak, C. Burdet, C. Laouenan, D. Belhadi, A. Dupont, T. Alfaiate, B. Basli, A. Chair, S. Laribi, J. Level, M. Schneider, M.C. Tellier, A. Dechanet, D. Costagliola, B. Terrier, M. Ohana, S. Couffin-Cadiergues, H. Esperou, C. Delmas, J. Saillard, C. Fougerou, L. Moinot, L. Wittkop, C. Cagnot, S. Le Mestre, D. Lebrasseur-Longuet, V. Petrov-Sanchez, A. Diallo, N. Mercier, V. Icard, B. Leveau, S. Tubiana, B. Hamze, A. Gelley, M. Noret, E. D’Ortenzio, O. Puechal, C. Semaille, T. Welte, J.A. Paiva, M. Halanova, M.P. Kieny, E. Balssa, C. Birkle, S. Gibowski, E. Landry, A. Le Goff, L. Moachon, C. Moins, L. Wadouachi, C. Paul, A. Levier, D. Bougon, F. Djossou, L. Epelboin, J. Dellamonica, C.H. Marquette, C. Robert, S. Gibot, E. Senneville, V. Jean-Michel, Y. Zerbib, C. Chirouze, A. Boyer, C. Cazanave, D. Gruson, D. Malvy, P. Andreu, J.P. Quenot, N. Terzi, K. Faure, C. Chabartier, V. Le Moing, K. Klouche, T. Ferry, F, Valour, B. Gaborit, E. Canet, P. Le Turnier, D. Boutoille, F. Bani-Sadr, F. Benezit, M. Revest, C. Cameli, A. Caro, MJ Ngo Um Tegue, Y. Le Tulzo, B. Laviolle, F. Laine, G. Thiery, F. Meziani, Y. Hansmann, W. Oulehri, C. Tacquard, F. Vardon-Bounes, B. Riu-Poulenc, M. Murris-Espin, L. Bernard, D. Garot, O. Hinschberger, M. Martinot, C. Bruel, B. Pilmis, O. Bouchaud, P. Loubet, C. Roger, X. Monnet, S. Figueiredo, V. Godard, J.P. Mira, M. Lachatre, S. Kerneis, J. Aboab, N. Sayre, F. Crockett, D. Lebeaux, A. Buffet, J.L. Diehl, A. Fayol, J.S. Hulot, M. Livrozet, A Mekontso- Dessap, C. Ficko, F. Stefan, J. Le Pavec, J. Mayaux, H. Ait-Oufella, J.M. Molina, G. Pialoux, M. Fartoukh, J. Textoris, M. Brossard, A. Essat, E. Netzer, Y. Riault, M. Ghislain, L. Beniguel, M. Genin, L. Gouichiche, C. Betard, L. Belkhir, A. Altdorfer, V Fraipont Centro, S. Braz, JM Ferreira Ribeiro, R Roncon Alburqueque, M. Berna, M. Alexandre, B. Lamprecht, A. Egle, R. Greil, M. Joannidis, Thomas F. Patterson, Philip O. Ponce, Barbara S. Taylor, Jan E. Patterson, Jason E. Bowling, Heta Javeri, LuAnn Larson, Angela Hewlett, Aneesh K. Mehta, Nadine G. Rouphael, Youssef Saklawi, Nicholas Scanlon, Jessica J. Traenkner, Ronald P. Trible, Jr., Emmanuel B. Walter, Noel Ivey, Thomas L. Holland, Guillermo M. Ruiz-Palacios, Alfredo Ponce de León, Sandra Rajme, Lanny Hsieh, Alpesh N. Amin, Miki Watanabe, Helen S. Lee, Susan Kline, Joanne Billings, Brooke Noren, Hyun Kim, Tyler D. Bold, Victor Tapson, Jonathan Grein, Fayyaz Sutterwala, Nicole Iovine, Lars K. Beattie, Rebecca Murray Wakeman, Matthew Shaw, Mamta K. Jain, Satish Mocherla, Jessica Meisner, Amneris Luque, Daniel A. Sweeney, Constance A. Benson, Farhana Ali, Robert L. Atmar, Hana M. El Sahly, Jennifer Whitaker, Ann R. Falsey, Angela R. Branche, Cheryl Rozario, Justino Regalado Pineda, José Arturo Martinez-Orozco, David Chien Lye, Sean WX. Ong, Po Ying Chia, Barnaby E. Young, Uriel Sandkovsky, Mezgebe Berhe, Clinton Haley, Emma Dishner, Valeria D. Cantos, Colleen F. Kelley, Paulina A. Rebolledo Esteinou, Sheetal Kandiah, Sarah B. Doernberg, Pierre-Cedric B. Crouch, Hannah Jang, Anne F. Luetkemeyer, Jay Dwyer, Stuart H. Cohen, George R. Thompson, 3rd, Hien H. Nguyen, Robert W. Finberg, Jennifer P. Wang, Juan Perez-Velazquez, Mireya Wessolossky, Patrick E.H. Jackson, Taison D. Bell, Miranda J. West, Babafemi Taiwo, Karen Krueger, Johnny Perez, Triniece Pearson, Catharine I. Paules, Kathleen G. Julian, Danish Ahmad, Alexander G. Hajduczok, Henry Arguinchona, Christa Arguinchona, Nathaniel Erdmann, Paul Goepfert, Neera Ahuja, Maria G. Frank, David Wyles, Heather Young, Myoung-don Oh, Wan Beom Park, Chang Kyung Kang, Vincent Marconi, Abeer Moanna, Sushma Cribbs, Telisha Harrison, Eu Suk Kim, Jongtak Jung, Kyoung-Ho Song, Hong Bin Kim, Seow Yen Tan, Humaira Shafi, MF Jaime Chien, Raymond KC. Fong, Daniel D. Murray, Jens Lundgren, Henrik Nielsen, Tomas Jensen, Barry S. Zingman, Robert Grossberg, Paul F. Riska, Otto O. Yang, Jenny Ahn, Rubi Arias, Rekha R. Rapaka, Naomi Hauser, James D. Campbell, William R. Short, Pablo Tebas, Jillian T. Baron, Susan L.F. McLellan, Lucas S. Blanton, Justin B. Seashore, C. Buddy Creech, Todd W. Rice, Shannon Walker, Isaac P. Thomsen, Diego Lopez de Castilla, Jason W. Van Winkle, Francis X. Riedo, Surinder Kaur Pada, Alvin DY. Wang, Li Lin, Michelle Harkins, Gregory Mertz, Nestor Sosa, Louis Yi Ann Chai, Paul Anantharajah Tambyah, Sai Meng Tham, Sophia Archuleta, Gabriel Yan, David A. Lindholm, Ana Elizabeth Markelz, Katrin Mende, Richard Mularski, Elizabeth Hohmann, Mariam Torres-Soto, Nikolaus Jilg, Ryan C. Maves, Gregory C. Utz, Sarah L. George, Daniel F. Hoft, James D. Brien, Roger Paredes, Lourdes Mateu, Cora Loste, Princy Kumar, Sarah Thornton, Sharmila Mohanraj, Noreen A. Hynes, Lauren M. Sauer, Christopher J. Colombo, Christina Schofield, Rhonda E. Colombo, Susan E. Chambers, Richard M. Novak, Andrea Wendrow, Samir K. Gupta, Tida Lee, Tahaniyat Lalani, Mark Holodniy, Aarthi Chary, Nikhil Huprikar, Anuradha Ganesan, Norio Ohmagari, Ayako Mikami, D. Ashley Price, Christopher J.A. Duncan, Kerry Dierberg, Henry J. Neumann, Stephanie N. Taylor, Alisha Lacour, Najy Masri, Edwin Swiatlo, Kyle Widmer, James D. Neaton, Mary Bessesen, David S. Stephens, Timothy H. Burgess, Timothy M. Uyeki, Robert Walker, G. Lynn Marks, Anu Osinusi, Huyen Cao, Anabela Cardoso, Stephanie de Bono, Douglas E. Schlichting, Kevin K. Chung, Jennifer L. Ferreira, Michelle Green, Mat Makowski, Michael R. Wierzbicki, Tom M. Conrad, Jill Ann El-Khorazaty, Heather Hill, Tyler Bonnett, Nikki Gettinger, Theresa Engel, Teri Lewis, Jing Wang, John H. Beigel, Kay M. Tomashek, Varduhi Ghazaryan, Tatiana Beresnev, Seema Nayak, Lori E. Dodd, Walla Dempsey, Effie Nomicos, Marina Lee, Rhonda Pikaart-Tautges, Mohamed Elsafy, Robert Jurao, Hyung Koo, Michael Proschan, Tammy Yokum, Janice Arega, Ruth Florese, Jocelyn D. Voell, Richard Davey, Ruth C. Serrano, Zanthia Wiley, Varun K. Phadke, Paul A. Goepfert, Carlos A. Gomez, Theresa A. Sofarelli, Laura Certain, Hannah N. Imlay, Cameron R. Wolfe, Emily R. Ko, John J. Engemann, Nora Bautista Felix, Claire R. Wan, Sammy T. Elmor, Laurel R. Bristow, Michelle S. Harkins, Nicole M. Iovine, Marie-Carmelle Elie-Turenne, Victor F. Tapson, Pyoeng Gyun Choe, Richard A. Mularski, Kevin S. Rhie, Rezhan H. Hussein, Dilek Ince, Patricia L. Winokur, Jin Takasaki, Sho Saito, Kimberly McConnell, PharmD, David L. Wyles, Ellen Sarcone, Kevin A. Grimes, Katherine Perez, Charles Janak, Jennifer A. Whitaker, Paulina A. Rebolledo, John Gharbin, Allison A. Lambert, Diego F. Zea, Emma Bainbridge, David C. Hostler, Jordanna M. Hostler, Brian T. Shahan, Evelyn Ling, Minjoung Go, Fleesie A. Hubbard, Melony Chakrabarty, Maryrose Laguio-Vila, Edward E. Walsh, Faheem Guirgis, Vincent C. Marconi, Christian Madar, Scott A. Borgetti, Corri Levine, Joy Nock, Keith Candiotti, Julia Rozman, Fernando Dangond, Yann Hyvert, Andrea Seitzinger, Kaitlyn Cross, Stephanie Pettibone, Seema U. Nayak, and Gregory A. Deye

Subjects
Acute respiratory distress syndrome, Acute hypoxemic respiratory failure, Pneumonia, Critically ill, Cancer, Medicine (General), R5-920
Abstract

Summary: Background: Although immunomodulators have established benefit against the new coronavirus disease (COVID-19) in general, it is uncertain whether such agents improve outcomes without increasing the risk of secondary infections in the specific subgroup of previously immunocompromised patients. We assessed the effect of immunomodulators on outcomes of immunocompromised patients hospitalized for COVID-19. Methods: The protocol was prospectively registered with PROSPERO (CRD42022335397). MEDLINE, Cochrane Central Register of Controlled Trials and references of relevant articles were searched up to 01-06-2022. Authors of potentially eligible randomized controlled trials were contacted to provide data on immunocompromised patients randomized to immunomodulators vs control (i.e., placebo or standard-of-care). Findings: Eleven randomized controlled trials involving 397 immunocompromised patients hospitalized for COVID-19 were included. Ten trials had low risk of bias. There was no difference between immunocompromised patients randomized to immunomodulators vs control regarding mortality [30/182 (16.5%) vs 41/215 (19.1%); RR 0.93, 95% CI 0.61–1.41; p = 0.74], secondary infections (RR 1.00, 95% CI 0.64–1.58; p = 0.99) and change in World Health Organization ordinal scale from baseline to day 15 (weighed mean difference 0.27, 95% CI -0.09–0.63; p = 0.15). In subgroup analyses including only patients with hematologic malignancy, only trials with low risk of bias, only trials administering IL-6 inhibitors, or only trials administering immunosuppressants, there was no difference between comparators regarding mortality. Interpretation: Immunomodulators, compared to control, were not associated with harmful or beneficial outcomes, including mortality, secondary infections, and change in ordinal scale, when administered to immunocompromised patients hospitalized for COVID-19. Funding: Hellenic Foundation for Research and Innovation.

Published
2024
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16. Incidence and risk factors of neonatal bacterial infections: a community-based cohort from Madagascar (2018–2021)

Author

Ines Devred, Lison Rambliere, Perlinot Herindrainy, Lovarivelo Andriamarohasina, Aina Harimanana, Frederique Randrianirina, Elisoa Hariniaina Ratsima, Delphine Hivernaud, Elsa Kermorvant-Duchemin, Zafitsara Zo Andrianirina, Armya Youssouf Abdou, Elisabeth Delarocque-Astagneau, Didier Guillemot, Tania Crucitti, Jean-Marc Collard, and Bich-Tram Huynh

Subjects
Neonatal, Severe Bacterial Infection, Antibiotic resistance, Madagascar, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Few studies on neonatal severe bacterial infection are available in LMICs. Data are needed in these countries to prioritize interventions and decrease neonatal infections which are a primary cause of neonatal mortality. The BIRDY project (Bacterial Infections and Antimicrobial Drug Resistant among Young Children) was initially conducted in Madagascar, Senegal and Cambodia (BIRDY 1, 2012–2018), and continued in Madagascar only (BIRDY 2, 2018–2021). We present here the BIRDY 2 project whose objectives were (1) to estimate the incidence of neonatal severe bacterial infections and compare these findings with those obtained in BIRDY 1, (2) to identify determinants associated with severe bacterial infection and (3) to specify the antibiotic resistance pattern of bacteria in newborns. Methods The BIRDY 2 study was a prospective community-based mother and child cohort, both in urban and semi-rural areas. All pregnant women in the study areas were identified and enrolled. Their newborns were actively and passively followed-up from birth to 3 months. Data on clinical symptoms developed by the children and laboratory results of all clinical samples investigated were collected. A Cox proportional hazards model was performed to identify risk factors associated with possible severe bacterial infection. Findings A total of 53 possible severe bacterial infection and 6 confirmed severe bacterial infection episodes were identified among the 511 neonates followed-up, with more than half occurring in the first 3 days. For the first month period, the incidence of confirmed severe bacterial infection was 11.7 per 1,000 live births indicating a 1.3 -fold decrease compared to BIRDY 1 in Madagascar (p = 0.50) and the incidence of possible severe bacterial infection was 76.3, indicating a 2.6-fold decrease compared to BIRDY 1 in Madagascar (p

Published
2023
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17. Global Ocean dimethylsulfide photolysis rates quantified with a spectrally and vertically resolved model

Author

Martí Galí, Emmanuel Devred, Gonzalo L. Pérez, David J. Kieber, and Rafel Simó

Subjects
Oceanography, GC1-1581
Abstract

Abstract Photochemical reactions initiated by ultraviolet radiation remove the climate‐active gas dimethylsulfide (DMS) from the ocean's surface layer. Here, we quantified DMS photolysis using a satellite‐based model that accounts for spectral irradiance attenuation in the water column, its absorption by chromophoric dissolved organic matter, and the apparent quantum yields (AQYs) with which absorbed photons degrade DMS. Models with two alternative parameterizations for AQY estimate global DMS photolysis at between 17 and 20 Tg S yr−1, equivalent to 13–15 Tg C yr−1, of which ~ 73% occurs in the Southern hemisphere. This asymmetry results mostly from the high AQYs found south of 40° S, which more than counteract the prevailing low irradiance and deep mixing in that region. Simplified schemes currently used in biogeochemical models, whereby photolysis follows the vertical attenuation of visible radiation, overestimate DMS photolysis by around 150% globally. We propose relevant corrections and simple adjustments to those models.

Published
2023
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18. Prophylaxis by doravirine-lamivudine-tenofovir disoproxil fumarate or elvitegravir-cobicistat-emtricitabine-tenofovir alafenamide after sexual exposure to HIV

Author

Inès Devred, Kick Kayembe, Nadia Valin, Hayette Rougier, Bruce Wuembulua Shinga, Sidonie Lambert-Niclot, Thibault Chiarabini, Marie-Caroline Meyohas, and Karine Lacombe

Subjects
Post-exposure prophylaxis, Doravirine, HIV, Adherence, Completion rate, Infectious and parasitic diseases, RC109-216
Abstract

Abstract HIV post- exposure prophylaxis (PEP) is a prevention tool for individuals with a recent potential exposure to HIV. Doravirine has been available since 2019 in combination with tenofovir disoproxil fumarate and lamivudine and has not been evaluated as a PEP. DOR/3TC/TDF is our department’s most commonly prescribed PEP treatment since 2021. This study evaluates the completion rate of the DOR/3TC/TDF as compared to EVG/c/FTC/TAF for PEP, which was the regimen prescribed until 2020 in our hospital. This retrospective observational study was conducted between January 2020 and September 2021. The subjects included consecutively were adults who consulted for an HIV sexual exposure accident and for whom DOR/3TC/TDF in 2021 or EVG/c/FTC/TAF in 2020 was prescribed. The outcomes were the completion rate to the end of treatment (28 days), the seroconversion rate, and the description of side effects. During the study period, 311 people were included: 140 treated with DOR/3TC/TDF and 171 treated with EVGc/FTC/TAF. Considering subjects with a follow-up visit, the completion rate was 96.8% (90/93) in the DOR/3TC/TDF group, and 94.6% (123/130) in the EVG/c/FTC/TAF group (p-value: 0.53). The number of people lost to follow-up was nearly equivalent in both groups: 27.1% (38/140) in the DOR/3TC/TDF group and 23.4% (40/171) in the EVG/c/FTC/TAF group (p-value: 0.45). A side effect was described for 38% (36/94) in the DOR/3TC/TDF group, and 29.7% (38/128) in the EVG/c/FTC/TAF group. No cases of seroconversion were observed. DOR/3TC/TDF appears to have a similar safety profile to EVG/c/FTC/TAF. Due to its lower cost, it seems to be a treatment option for consideration in the context of HIV-exposure accidents.

Published
2023
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19. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials

Author

Hermine, Olivier, Mariette, Xavier, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Resche-Rigon, Matthieu, Tharaux, Pierre-Louis, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Porcher, Raphaël, Pourchet-Martinez, Valerie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Raked, Nabil, Mameri, Lakhdar, Montlahuc, Claire, Biard, Lucie, Alary, St.phanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Charreteur, Robin, Dupre, Céline, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, Laurent, Harrois, Anatole, Figueiredo, Samy, Duranteau, Jacques, Anguel, Nadia, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Teboul, Jean-Louis, Durand, Philippe, Tissieres, Pierre, Jevnikar, Mitja, Montani, David, Pavy, Stephan, Nocturne, Gaétane, Bitoun, Samuel, Noel, Nicolas, Lambotte, Olivier, Escaut, Lelia, Jauréguiberry, Stephane, Baudry, Elodie, Verny, Christiane, Lefevre, Edouard, Zaidan, Mohamad, Molinari, Domitille, Leprun, Gaël, Fourreau, Alain, Cylly, Laurent, Grimaldi, Lamiae, Virlouvet, Myriam, Meftali, Ramdane, Fabre, Soléne, Licois, Marion, Mamoune, Asmaa, Boudali, Yacine, Le Tiec, Clotilde, Verstuyft, Céline, Roques, Anne-Marie, Georgin-Lavialle, Sophie, Senet, Patricia, Pialoux, Gilles, Soria, Angele, Parrot, Antoine, François, Helene, Rozensztajn, Nathalie, Blin, Emmanuelle, Choinier, Pascaline, Camuset, Juliette, Rech, Jean-Simon, Canellas, Antony, Rolland-Debord, Camille, Lemarié, Nadege, Belaube, Nicolas, Nadal, Marine, Siguier, Martin, Petit-Hoang, Camille, Chas, Julie, Drouet, Elodie, Lemoine, Matthieu, Phibel, Audrey, Aunay, Lucie, Bertrand, Eliane, Ravato, Sylviane, Vayssettes, Marie, Adda, Anne, Wilpotte, Celine, Thibaut, Pélagie, Fillon, Julie, Debrix, Isabelle, Fellahi, Soraya, Bastard, Jean-Philippe, Lefévre, Guillaume, Gottenberg, Jacques-Eric, Hansmann, Yves, Blanc, Frédéric, Ohlmann-Caillard, Sophie, Castelain, Vincent, Chatelus, Emmanuel, Chatron, Eva, Collange, Olivier, Danion, François, De Blay, Frédéric, Diemunsch, Pierre, Diemunsch, Sophie, Felten, Renaud, Goichot, Bernard, Greigert, Valentin, Guffroy, Aurelien, Heger, Bob, Kaeuffer, Charlotte, Kassegne, Loic, Korganow, Anne Sophie, Le Borgne, Pierrick, Lefebvre, Nicolas, Mertes, Paul-Michel, Noll, Eric, Oberlin, Mathieu, Poindron, Vincent, Pottecher, Julien, Ruch, Yvon, Weill, François, Meyer, Nicolas, Andres, Emmanuel, Demonsant, Eric, Tayebi, Hakim, Nisand, Gabriel, Brin, Stéphane, Sublon, Cédric, Becker, Guillaume, Hutt, Anne, Martin, Tristan, Bayer, Sophie, Metzger, Catherine, Mekinian, Arsene, Abisror, Noémie, Adedjouma, Amir, Bollens, Diane, Bonneton, Marion, Bourcicaux, Nathalie, Bourrier, Anne, Thibault Chiarabiani, Maria Chauchard, Chopin, Doroth.e, Cohen, Jonathan, Devred, Ines, Donadille, Bruno, Fain, Olivier, Hariri, Geoffrey, Jachiet, Vincent, Ingliz, Patrick, Garnier, Marc, Gatfosse, Marc, Ghrenassia, Etienne, Gobert, Delphine, Krause le Garrec, Jessica, Landman, Cecilia, Lavillegrand, Jean Remy, Lefebvre, Benedicte, Mahevas, Thibault, Mazerand, Sandie, Meynard, Jean Luc, Morgand, Marjolaine, Ouaz.ne, Zineb, Pacanowski, Jerome, Riviere, S.bastien, Seksik, Philippe, Sokol, Harry, Soliman, Heithem, Valin, Nadia, Urbina, Thomas, McAvoy, Chloé, Miranda, Maria Pereira, Aratus, Gladys, Berard, Laurence, Simon, Tabassome, Nguyen, Anne Daguenel, Girault, Elise, Mayala-Kanda, Cl.mentine, Antignac, Marie, Leplay, Céline, Arlet, Jean-Benoit, Diehl, Jean-Luc, Bellenfant, Florence, Blanchard, Anne, Buffet, Alexandre, Cholley, Bernard, Fayol, Antoine, Flamarion, Edouard, Godier, Anne, Gorget, Thomas, Hamada, Sophie-Rym, Hauw-Berlemont, Caroline, Hulot, Jean-Sébastien, Lebeaux, David, Livrozet, Marine, Michon, Adrien, Neuschwander, Arthur, Pennet, Marie-Aude, Planquette, Benjamin, Ranque, Brigitte, Sanchez, Olivier, Volle, Geoffroy, Briois, Sandrine, Cornic, Mathias, Elisee, Virginie, Denis, Jesuthasan, Djadi-Prat, Juliette, Jouany, Pauline, Junquera, Ramon, Henriques, Mickael, Kebir, Amina, Lehir, Isabelle, Meunier, Jeanne, Patin, Florence, Paquet, Val.rie, Tréhan, Anne, Vigna, Véronique, Sabatier, Brigitte, Bergerot, Damien, Jouve, Charléne, Knosp, Camille, Lenoir, Olivia, Mahtal, Nassim, Resmini, Léa, Lescure, Xavier, Ghosn, Jade, Bachelard, Antoine, Rachline, Anne, Isernia, Valentina, Bao-chau, Phung, Vallois, Dorothée, Sautereau, Aurelie, Neukrich, Catherine, Dossier, Antoine, Borie, Raphaël, Crestani, Bruno, Ducrocq, Gregory, Steg, Philippe Gabriel, Dieude, Philippe, Papo, Thomas, Marcault, Estelle, Chaudhry, Marhaba, Da Silveira, Charléne, Metois, Annabelle, Mahenni, Ismahan, Meziani, Meriam, Nilusmas, Cyndie, Le Gac, Sylvie, Ndiaye, Awa, Louni, Fran.oise, Chansombat, Malikhone, Julia, Zelie, Chalal, Solaya, Chalal, Lynda, Kramer, Laura, Le Grand, Jeniffer, Ouifiya, Kafif, Piquard, Valentine, Tubiana, Sarah, Nguyen, Yann, Honsel, Vasco, Weiss, Emmanuel, Codorniu, Anais, Zarrouk, Virginie, de Lastours, Victoire, Uzzan, Matthieu, Gamany, Naura, Claveirole, Agathe, Navid, Alexandre, Fouque, Tiffanie, Cohen, Yonathan, Lupo, Maya, Gilles, Constance, Rahli, Roza, Louis, Zeina, Boutboul, David, Galicier, Lionel, Amara, Yaël, Archer, Gabrielle, Benattia, Amira, Bergeron, Anne, Bondeelle, Louise, de Castro, Nathalie, Clément, Melissa, Darmon, Michaël, Denis, Blandine, Dupin, Clairelyne, Feredj, Elsa, Feyeux, Delphine, Joseph, Adrien, Lenglin, Etienne, Le Guen, Pierre, Liégeon, Geoffroy, Lorillon, Gwenaël, Mabrouki, Asma, Mariotte, Eric, Martin de Frémont, Grégoire, Mirouse, Adrien, Molina, Jean-Michel, Peffault de Latour, Régis, Oksenhendler, Eric, Saussereau, Julien, Tazi, Abdellatif, Tudesq, Jean-Jacques, Zafrani, Lara, Brindele, Isabelle, Bugnet, Emmanuelle, Lebras, Karine Celli, Chabert, Julien, Djaghout, Lamia, Fauvaux, Catherine, Jegu, Anne Lise, Kozakiewicz, Ewa, Meunier, Martine, Tremorin, Marie-Thérèse, Davoine, Claire, Madelaine, Isabelle, Caillat-Zucman, Sophie, Delaugerre, Constance, Morin, Florence, Sène, Damien, Burlacu, Ruxandra, Chousterman, Benjamin, Mégarbanne, Bruno, Richette, Pascal, Riveline, Jean-Pierre, Frazier, Aline, Vicaut, Eric, Berton, Laure, Hadjam, Tassadit, Vazquez-Ibarra, Miguel Alejandro, Jourdaine, Clément, Tran, Olivia, Jouis, Véronique, Jacob, Aude, Smati, Julie, Renaud, Stéphane, Pernin, Claire, Suarez, Lydia, Semerano, Luca, Abad, Sébastien, nainous, Ruben B., Bonnet, Nicolas, Comparon, Celine, Cohen, Yves, Cordel, Hugues, Dhote, Robin, Dournon, Nathalie, Duchemann, Boris, Ebstein, Nathan, Gille, Thomas, Giroux-Leprieur, Benedicte, Goupil de Bouille, Jeanne, Nunes, Hilario, Oziel, Johanna, Roulot, Dominique, Sese, Lucile, ClaireTantet, Uzunhan, Yurdagul, Bloch-Queyrat, Coralie, Levy, Vincent, Messani, Fadhila, Rahaoui, Mohammed, Petit, Myléne, Brahmi, Sabrina, Rathoin, Vanessa, Rigal, Marthe, Costedoat-Chalumeau, Nathalie, Luong, Liem Binh, Hamou, Zakaria Ait, Benghanem, Sarah, Blanche, Philippe, Carlier, Nicolas, Chaigne, Benjamin, Gauzit, Remy, Joumaa, Hassan, Jozwiak, Mathieu, Lachétre, Marie, Lafoeste, Hélène, Launay, Odie, Legendre, Paul, Marey, Jonathan, Morbieu, Caroline, Palmieri, Lola-Jade, Szwebel, Tali-Anne, Abdoul, Hendy, Bruneau, Alexandra, Beclin-Clabaux, Audrey, Larrieu, Charly, Montanari, Pierre, Dufour, Eric, Clarke, Ada, Le Bourlout, Catherine, Marin, Nathalie, Menage, Nathalie, Saleh-Mghir, Samira, Cisse, Mamadou Salif, Cheref, Kahina, Guerin, Corinne, Zerbit, Jérémie, Michel, Marc, Gallien, Sébastien, Crickx, Etienne, Le Vavasseur, Benjamin, Kempf, Emmanuelle, Jaffal, Karim, Vindrios, William, Oniszczuk, Julie, Guillaud, Constance, Lim, Pascal, Fois, Elena, Melica, Giovanna, Matignon, Marie, Jalabert, Maud, Lelièvre, Jean-Daniel, Schmitz, David, Bourhis, Marion, Belazouz, Sylia, Languille, Laetitia, Boucle, Caroline, Cita, Nelly, Didier, Agnés, Froura, Fahem, Ledudal, Katia, Sadaoui, Thiziri, Thiemele, Alaki, Le Febvre De Bailly, Delphine, Verlinde, Muriel Carvhalo, Mayaux, Julien, Cacoub, Patrice, Saadoun, David, Vautier, Mathieu, Bugaut, Héléne, Benveniste, Olivier, Allenbach, Yves, Leroux, Gaëlle, Rigolet, Aude, Guillaume-Jugnot, Perrine, Domont, Fanny, Desbois, Anne Claire, Comarmond, Chloé, Champtiaux, Nicolas, Toquet, Segolene, Ghembaza, Amine, Vieira, Matheus, Maalouf, Georgina, Boleto, Goncalo, Ferfar, Yasmina, Corvol, Jean-Christophe, Louapre, C.line, Sambin, Sara, Mariani, Louise-Laure, Karachi, Carine, Tubach, Florence, Estellat, Candice, Gimeno, Linda, Martin, Karine, Bah, Aicha, Keo, Vixra, Ouamri, Sabrine, Messaoudi, Yasmine, Yelles, Nessima, Faye, Pierre, Cavelot, Sebastien, Larcheveque, Cecile, Annonay, Laurence, Benhida, Jaouad, Zahrate-Ghoul, Aida, Hammal, Soumeya, Belilita, Ridha, Charbonnier, Fanny, Aguilar, Claire, Alby-Laurent, Fanny, Burger, Carole, Campos-Vega, Clara, Chavarot, Nathalie, Fournier, Benjamin, Rouzaud, Claire, Vimpére, Damien, Elie, Caroline, Bakouboula, Prissile, Choupeaux, Laure, Granville, Sophie, Issorat, Elodie, Broissand, Christine, Alyanakian, Marie-Alexandra, Geri, Guillaume, Derridj, Nawal, Sguiouar, Naima, Meddah, Hakim, Djadel, Mourad, Chambrin-Lauvray, Héléne, Duclos-vallée, Jean-Charles, Saliba, Faouzi, Sacleux, Sophie-Caroline, Kounis, Ilias, Tamazirt, Sonia, Rudant, Eric, Michot, Jean-Marie, Stoclin, Annabelle, Colomba, Emeline, Pommeret, Fanny, Willekens, Christophe, Da Silva, Rosa, Dejean, Valérie, Mekid, Yasmina, Ben-Mabrouk, Ines, Netzer, Florence, Pradon, Caroline, Drouard, Laurence, Camara-Clayette, Valérie, Morel, Alexandre, Garcia, Gilles, Mohebbi, Abolfazl, Berbour, Férial, Dehais, Mélanie, Pouliquen, Anne-Lise, Klasen, Alison, Soyez-Herkert, Loren, London, Jonathan, Keroumi, Younes, Guillot, Emmanuelle, Grailles, Guillaume, El amine, Younes, Defrancq, Fanny, Fodil, Hanane, Bouras, Chaouki, Dautel, Dominique, Gambier, Nicolas, Dieye, Thierno, Bienvenu, Boris, Lancon, Victor, Lecomte, Laurence, Beziriganyan, Kristina, Asselate, Belkacem, Allanic, Laure, Kiouris, Elena, Legros, Marie-Héléne, Lemagner, Christine, Martel, Pascal, Provitolo, Vincent, Ackermann, Félix, Le Marchand, Mathilde, Chan Hew Wai, Aurélie, Fremont, Dimitri, Coupez, Elisabeth, Adda, Mireille, Duée, Frédéric, Bernard, Lise, Gros, Antoine, Henry, Estelle, Courtin, Claire, Pattyn, Anne, Guinot, Pierre-Grégoire, Bardou, Marc, Maurer, Agnes, Jambon, Julie, Cransac, Amélie, Pernot, Corinne, Mourvillier, Bruno, Marquis, Eric, Benoit, Philippe, Roux, Damien, Gernez, Coralie, Yelnik, Cécile, Poissy, Julien, Nizard, Mandy, Denies, Fanette, Gros, Helene, Mourad, Jean-Jacques, Sacco, Emmanuelle, Renet, Sophie, Ader, F., Yazdanpanah, Y., Mentre, F., Peiffer-Smadja, N., Lescure, F.X., Poissy, J., Bouadma, L., Timsit, J.F., Lina, B., Morfin-Sherpa, F., Bouscambert, M., Gaymard, A., Peytavin, G., Abel, L., Guedj, J., Andrejak, C., Burdet, C., Laouenan, C., Belhadi, D., Dupont, A., Alfaiate, T., Basli, B., Chair, A., Laribi, S., Level, J., Schneider, M., Tellier, M.C., Dechanet, A., Costagliola, D., Terrier, B., Ohana, M., Couffin-Cadiergues, S., Esperou, H., Delmas, C., Saillard, J., Fougerou, C., Moinot, L., Wittkop, L., Cagnot, C., Le Mestre, S., Lebrasseur-Longuet, D., Petrov-Sanchez, V., Diallo, A., Mercier, N., Icard, V., Leveau, B., Tubiana, S., Hamze, B., Gelley, A., Noret, M., D’Ortenzio, E., Puechal, O., Semaille, C., Welte, T., Paiva, J.A., Halanova, M., Kieny, M.P., Balssa, E., Birkle, C., Gibowski, S., Landry, E., Le Goff, A., Moachon, L., Moins, C., Wadouachi, L., Paul, C., Levier, A., Bougon, D., Djossou, F., Epelboin, L., Dellamonica, J., Marquette, C.H., Robert, C., Gibot, S., Senneville, E., Jean-Michel, V., Zerbib, Y., Chirouze, C., Boyer, A., Cazanave, C., Gruson, D., Malvy, D., Andreu, P., Quenot, J.P., Terzi, N., Faure, K., Chabartier, C., Le Moing, V., Klouche, K., Ferry, T., F, Valour, Gaborit, B., Canet, E., Le Turnier, P., Boutoille, D., Bani-Sadr, F., Benezit, F., Revest, M., Cameli, C., Caro, A., Um Tegue, MJ Ngo, Le Tulzo, Y., Laviolle, B., Laine, F., Thiery, G., Meziani, F., Hansmann, Y., Oulehri, W., Tacquard, C., Vardon-Bounes, F., Riu-Poulenc, B., Murris-Espin, M., Bernard, L., Garot, D., Hinschberger, O., Martinot, M., Bruel, C., Pilmis, B., Bouchaud, O., Loubet, P., Roger, C., Monnet, X., Figueiredo, S., Godard, V., Mira, J.P., Lachatre, M., Kerneis, S., Aboab, J., Sayre, N., Crockett, F., Lebeaux, D., Buffet, A., Diehl, J.L., Fayol, A., Hulot, J.S., Livrozet, M., Dessap, A Mekontso, Ficko, C., Stefan, F., Le Pavec, J., Mayaux, J., Ait-Oufella, H., Molina, J.M., Pialoux, G., Fartoukh, M., Textoris, J., Brossard, M., Essat, A., Netzer, E., Riault, Y., Ghislain, M., Beniguel, L., Genin, M., Gouichiche, L., Betard, C., Belkhir, L., Altdorfer, A., Centro, V Fraipont, Braz, S., Ribeiro, JM Ferreira, Alburqueque, R Roncon, Berna, M., Alexandre, M., Lamprecht, B., Egle, A., Greil, R., Joannidis, M., Patterson, Thomas F., Ponce, Philip O., Taylor, Barbara S., Patterson, Jan E., Bowling, Jason E., Javeri, Heta, Kalil, Andre C., Larson, LuAnn, Hewlett, Angela, Mehta, Aneesh K., Rouphael, Nadine G., Saklawi, Youssef, Scanlon, Nicholas, Traenkner, Jessica J., Trible, Ronald P., Jr., Walter, Emmanuel B., Ivey, Noel, Holland, Thomas L., Ruiz-Palacios, Guillermo M., Ponce de León, Alfredo, Rajme, Sandra, Hsieh, Lanny, Amin, Alpesh N., Watanabe, Miki, Lee, Helen S., Kline, Susan, Billings, Joanne, Noren, Brooke, Kim, Hyun, Bold, Tyler D., Tapson, Victor, Grein, Jonathan, Sutterwala, Fayyaz, Iovine, Nicole, Beattie, Lars K., Wakeman, Rebecca Murray, Shaw, Matthew, Jain, Mamta K., Mocherla, Satish, Meisner, Jessica, Luque, Amneris, Sweeney, Daniel A., Benson, Constance A., Ali, Farhana, Atmar, Robert L., El Sahly, Hana M., Whitaker, Jennifer, Falsey, Ann R., Branche, Angela R., Rozario, Cheryl, Pineda, Justino Regalado, Martinez-Orozco, José Arturo, Lye, David Chien, Ong, Sean WX., Chia, Po Ying, Young, Barnaby E., Sandkovsky, Uriel, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Cantos, Valeria D., Kelley, Colleen F., Rebolledo Esteinou, Paulina A., Kandiah, Sheetal, Doernberg, Sarah B., Crouch, Pierre-Cedric B., Jang, Hannah, Luetkemeyer, Anne F., Dwyer, Jay, Cohen, Stuart H., Thompson, George R., 3rd, Nguyen, Hien H., Finberg, Robert W., Wang, Jennifer P., Perez-Velazquez, Juan, Wessolossky, Mireya, Jackson, Patrick E.H., Bell, Taison D., West, Miranda J., Taiwo, Babafemi, Krueger, Karen, Perez, Johnny, Pearson, Triniece, Paules, Catharine I., Julian, Kathleen G., Ahmad, Danish, Hajduczok, Alexander G., Arguinchona, Henry, Arguinchona, Christa, Erdmann, Nathaniel, Goepfert, Paul, Ahuja, Neera, Frank, Maria G., Wyles, David, Young, Heather, Oh, Myoung-don, Park, Wan Beom, Kang, Chang Kyung, Marconi, Vincent, Moanna, Abeer, Cribbs, Sushma, Harrison, Telisha, Kim, Eu Suk, Jung, Jongtak, Song, Kyoung-Ho, Kim, Hong Bin, Tan, Seow Yen, Shafi, Humaira, Chien, Jaime, Fong, Raymond KC., Murray, Daniel D., Lundgren, Jens, Nielsen, Henrik, Jensen, Tomas, Zingman, Barry S., Grossberg, Robert, Riska, Paul F., Yang, Otto O., Ahn, Jenny, Arias, Rubi, Rapaka, Rekha R., Hauser, Naomi, Campbell, James D., Short, William R., Tebas, Pablo, Baron, Jillian T., McLellan, Susan L.F., Blanton, Lucas S., Seashore, Justin B., Creech, C. Buddy, Rice, Todd W., Walker, Shannon, Thomsen, Isaac P., Lopez de Castilla, Diego, Van Winkle, Jason W., Riedo, Francis X., Pada, Surinder Kaur, Wang, Alvin DY., Lin, Li, Harkins, Michelle, Mertz, Gregory, Sosa, Nestor, Ann Chai, Louis Yi, Tambyah, Paul Anantharajah, Tham, Sai Meng, Archuleta, Sophia, Yan, Gabriel, Lindholm, David A., Markelz, Ana Elizabeth, Mende, Katrin, Mularski, Richard, Hohmann, Elizabeth, Torres-Soto, Mariam, Jilg, Nikolaus, Maves, Ryan C., Utz, Gregory C., George, Sarah L., Hoft, Daniel F., Brien, James D., Paredes, Roger, Mateu, Lourdes, Loste, Cora, Kumar, Princy, Thornton, Sarah, Mohanraj, Sharmila, Hynes, Noreen A., Sauer, Lauren M., Colombo, Christopher J., Schofield, Christina, Colombo, Rhonda E., Chambers, Susan E., Novak, Richard M., Wendrow, Andrea, Gupta, Samir K., Lee, Tida, Lalani, Tahaniyat, Holodniy, Mark, Chary, Aarthi, Huprikar, Nikhil, Ganesan, Anuradha, Ohmagari, Norio, Mikami, Ayako, Price, D. Ashley, Duncan, Christopher J.A., Dierberg, Kerry, Neumann, Henry J., Taylor, Stephanie N., Lacour, Alisha, Masri, Najy, Swiatlo, Edwin, Widmer, Kyle, Neaton, James D., Bessesen, Mary, Stephens, David S., Burgess, Timothy H., Uyeki, Timothy M., Walker, Robert, Marks, G. Lynn, Osinusi, Anu, Cao, Huyen, Cardoso, Anabela, de Bono, Stephanie, Schlichting, Douglas E., Chung, Kevin K., Ferreira, Jennifer L., Green, Michelle, Makowski, Mat, Wierzbicki, Michael R., Conrad, Tom M., El-Khorazaty, Jill Ann, Hill, Heather, Bonnett, Tyler, Gettinger, Nikki, Engel, Theresa, Lewis, Teri, Wang, Jing, Beigel, John H., Tomashek, Kay M., Ghazaryan, Varduhi, Beresnev, Tatiana, Nayak, Seema, Dodd, Lori E., Dempsey, Walla, Nomicos, Effie, Lee, Marina, Pikaart-Tautges, Rhonda, Elsafy, Mohamed, Jurao, Robert, Koo, Hyung, Proschan, Michael, Yokum, Tammy, Arega, Janice, Florese, Ruth, Voell, Jocelyn D., Davey, Richard, Serrano, Ruth C., Wiley, Zanthia, Phadke, Varun K., Goepfert, Paul A., Gomez, Carlos A., Sofarelli, Theresa A., Certain, Laura, Imlay, Hannah N., Wolfe, Cameron R., Ko, Emily R., Engemann, John J., Felix, Nora Bautista, Wan, Claire R., Elmor, Sammy T., Bristow, Laurel R., Harkins, Michelle S., Iovine, Nicole M., Elie-Turenne, Marie-Carmelle, Tapson, Victor F., Choe, Pyoeng Gyun, Mularski, Richard A., Rhie, Kevin S., Hussein, Rezhan H., Ince, Dilek, Winokur, Patricia L., Takasaki, Jin, Saito, Sho, McConnell, Kimberly, Wyles, David L., Sarcone, Ellen, Grimes, Kevin A., Perez, Katherine, Janak, Charles, Whitaker, Jennifer A., Rebolledo, Paulina A., Gharbin, John, Lambert, Allison A., Zea, Diego F., Bainbridge, Emma, Hostler, David C., Hostler, Jordanna M., Shahan, Brian T., Ling, Evelyn, Go, Minjoung, Hubbard, Fleesie A., Chakrabarty, Melony, Laguio-Vila, Maryrose, Walsh, Edward E., Guirgis, Faheem, Marconi, Vincent C., Madar, Christian, Borgetti, Scott A., Levine, Corri, Nock, Joy, Candiotti, Keith, Rozman, Julia, Dangond, Fernando, Hyvert, Yann, Seitzinger, Andrea, Cross, Kaitlyn, Pettibone, Stephanie, Nayak, Seema U., Deye, Gregory A., Siempos, Ilias I., Belhadi, Drifa, Veiga, Viviane Cordeiro, Cavalcanti, Alexandre Biasi, Branch-Elliman, Westyn, Papoutsi, Eleni, Gkirgkiris, Konstantinos, Xixi, Nikoleta A., and Kotanidou, Anastasia

Published
2024
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20. An AI-powered blood test to detect cancer using nanoDSF

Author

Tsvetkov, Philipp O., Eyraud, Rémi, Ayache, Stéphane, Bougaev, Anton A., Malesinski, Soazig, Benazha, Hamed, Gorokhova, Svetlana, Buffat, Christophe, Dehais, Caroline, Sanson, Marc, Bielle, Franck, Figarella-Branger, Dominique, Chinot, Olivier, Tabouret, Emeline, and Devred, François

Subjects
Quantitative Biology - Quantitative Methods, Computer Science - Machine Learning, Quantitative Biology - Tissues and Organs
Abstract

We describe a novel cancer diagnostic method based on plasma denaturation profiles obtained by a non-conventional use of Differential Scanning Fluorimetry. We show that 84 glioma patients and 63 healthy controls can be automatically classified using denaturation profiles with the help of machine learning algorithms with 92% accuracy. Proposed high throughput workflow can be applied to any type of cancer and could become a powerful pan-cancer diagnostic and monitoring tool from a simple blood test.

Published
2020

21. First CERN Cold Masses for the HL-LHC Interaction Regions

Author

Prin, Herve, primary, Axensalva, Jerome, additional, Bampton, Tavis, additional, Bourcey, Nicolas, additional, Devred, Arnaud, additional, Ramos, Delio Duarte, additional, Troitino, Jose Ferradas, additional, Bermudez, Susana Izquierdo, additional, Milanese, Attilio, additional, Pentella, Mariano, additional, Petrone, Carlo, additional, Principe, Rosario, additional, Rogacki, Piotr, additional, Straarup, Simon, additional, and Todesco, Ezio, additional

Published
2024
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22. Nunataryuk field campaigns: understanding the origin and fate of terrestrial organic matter in the coastal waters of the Mackenzie Delta region

Author

M. Lizotte, B. Juhls, A. Matsuoka, P. Massicotte, G. Mével, D. O. J. Anikina, S. Antonova, G. Bécu, M. Béguin, S. Bélanger, T. Bossé-Demers, L. Bröder, F. Bruyant, G. Chaillou, J. Comte, R.-M. Couture, E. Devred, G. Deslongchamps, T. Dezutter, M. Dillon, D. Doxaran, A. Flamand, F. Fell, J. Ferland, M.-H. Forget, M. Fritz, T. J. Gordon, C. Guilmette, A. Hilborn, R. Hussherr, C. Irish, F. Joux, L. Kipp, A. Laberge-Carignan, H. Lantuit, E. Leymarie, A. Mannino, J. Maury, P. Overduin, L. Oziel, C. Stedmon, C. Thomas, L. Tisserand, J.-É. Tremblay, J. Vonk, D. Whalen, and M. Babin

Subjects
Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract

Climate warming and related drivers of soil thermal change in the Arctic are expected to modify the distribution and dynamics of carbon contained in perennially frozen grounds. Thawing of permafrost in the Mackenzie River watershed of northwestern Canada, coupled with increases in river discharge and coastal erosion, triggers the release of terrestrial organic matter (OMt) from the largest Arctic drainage basin in North America into the Arctic Ocean. While this process is ongoing and its rate is accelerating, the fate of the newly mobilized organic matter as it transits from the watershed through the delta and into the marine system remains poorly understood. In the framework of the European Horizon 2020 Nunataryuk programme, and as part of the Work Package 4 (WP4) Coastal Waters theme, four field expeditions were conducted in the Mackenzie Delta region and southern Beaufort Sea from April to September 2019. The temporal sampling design allowed the survey of ambient conditions in the coastal waters under full ice cover prior to the spring freshet, during ice breakup in summer, and anterior to the freeze-up period in fall. To capture the fluvial–marine transition zone, and with distinct challenges related to shallow waters and changing seasonal and meteorological conditions, the field sampling was conducted in close partnership with members of the communities of Aklavik, Inuvik and Tuktoyaktuk, using several platforms, namely helicopters, snowmobiles, and small boats. Water column profiles of physical and optical variables were measured in situ, while surface water, groundwater, and sediment samples were collected and preserved for the determination of the composition and sources of OMt, including particulate and dissolved organic carbon (POC and DOC), and colored dissolved organic matter (CDOM), as well as a suite of physical, chemical, and biological variables. Here we present an overview of the standardized datasets, including hydrographic profiles, remote sensing reflectance, temperature and salinity, particle absorption, nutrients, dissolved organic carbon, particulate organic carbon, particulate organic nitrogen, CDOM absorption, fluorescent dissolved organic matter intensity, suspended particulate matter, total particulate carbon, total particulate nitrogen, stable water isotopes, radon in water, bacterial abundance, and a string of phytoplankton pigments including total chlorophyll. Datasets and related metadata can be found in Juhls et al. (2021) (https://doi.org/10.1594/PANGAEA.937587).

Published
2023
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23. An innovative Superconducting Recoil Separator for HIE-ISOLDE

Author

Martel, I., Acosta, L., Aguado, J.L., Assie, M., Al-Aqeel, M.A.M., Ballarino, A., Barna, D., Berjillos, R., Bonora, M., Bontoiu, C., Borge, M.J.G., Briz, J.A., Bustinduy, I., Bottura, L., Catalina-Medina, L., Catford, W., Cederkäll, J., Davinson, T., de Angelis, G., Devred, A., Díaz-Martín, C., Ekelöf, T., Felice, H., Fynbo, H., Foussat, A.P., Florin, R., Freeman, S.J., Gaffney, L., García-Ramos, C., Gentini, L., Gonzalez-Cordero, C.A., Guazzoni, C., Haziot, A., Heinz, A., Jimenez, J.M., Johnston, K., Jonson, B., Kirby, G., Kirby, O., Kurtukian-Nieto, T., Labiche, M., Liebsch, M., Losasso, M., Laird, A., Muñoz, J.L., Nara Singh, B.S., Neyens, G., Napiorkowski, P.J., O'Donnell, D., Page, R.D., Perini, D., Resta-López, J., Riddone, G., Rodriguez, J.A., Rodin, V., Russenschuck, S., Sharma, V.R., Salguero-Andújar, F., Sánchez-Segovia, J., Riisager, K., Sánchez-Benítez, A.M., Shepherd, B., Siesling, E., Smallcombe, J., Stanoiu, M., Tengblad, O., Thermeau, J.P., Tommasini, D., Uusitalo, J., Varnasseri, S., Welsch, C.P., and Willering, G.

Published
2023
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24. Exploring the Influence of Zinc Ions on the Conformational Stability and Activity of Protein Disulfide Isomerase

Author

Ana Iochabel Soares Moretti, Viktoria E. Baksheeva, Andrei Yu. Roman, Tiphany Coralie De Bessa, François Devred, Hervé Kovacic, and Philipp O. Tsvetkov

Subjects
neurophysiopathology, thiol proteins, protein disulfide isomerase, zinc binding, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

The interplay between metal ion binding and the activity of thiol proteins, particularly within the protein disulfide isomerase family, remains an area of active investigation due to the critical role that these proteins play in many vital processes. This research investigates the interaction between recombinant human PDIA1 and zinc ions, focusing on the subsequent implications for PDIA1’s conformational stability and enzymatic activity. Employing isothermal titration calorimetry and differential scanning calorimetry, we systematically compared the zinc binding capabilities of both oxidized and reduced forms of PDIA1 and assessed the structural consequences of this interaction. Our results demonstrate that PDIA1 can bind zinc both in reduced and oxidized states, but with significantly different stoichiometry and more pronounced conformational effects in the reduced form of PDIA1. Furthermore, zinc binding was observed to inhibit the catalytic activity of reduced-PDIA1, likely due to induced alterations in its conformation. These findings unveil a potential regulatory mechanism in PDIA1, wherein metal ion binding under reductive conditions modulates its activity. Our study highlights the potential role of zinc in regulating the catalytic function of PDIA1 through conformational modulation, suggesting a nuanced interplay between metal binding and protein stability in the broader context of cellular redox regulation.

Published
2024
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25. Environmental drivers of beluga whale distribution in a changing climate: a case study of summering aggregations in the Mackenzie Estuary and Tarium Niryutait Marine Protected Area

Author

Aurélie Noel, John Iacozza, Emmanuel Devred, Marianne Marcoux, Claire Hornby, and Lisa L. Loseto

Subjects
Resource Selection Function, beluga whales, summer habitat, TNMPA, species distribution model, fonction de sélection de ressources, Environmental sciences, GE1-350, Environmental engineering, TA170-171
Abstract

During summer, the Eastern Beaufort Sea beluga whale (Delphinapterus leucas (Pallas, 1776)) population aggregates in the waters of the Mackenzie Estuary and Tarium Niryutait Marine Protected Area (TNMPA). Guided by local communities’ priorities, this study aimed to better understand beluga summer habitat selection and to examine whether shifts in beluga distribution are expected under a changing climate. We used a resource selection function (RSF) based on aerial survey data and satellite remote sensing images to estimate the likelihood of beluga presence as a function of environmental conditions. The RSF revealed that belugas selected warm and turbid waters, with suspended particulate matter concentrations and sea surface temperatures ranging above average estuarine values. These specific conditions support hypotheses on the ecological roles of estuaries for belugas such as providing a thermal advantage for their calves or for beluga epidermal moulting. Using a diachronic analysis, we found a distribution shift towards coastal and inshore waters, areas already experiencing effects of climate change. Thus, the current distribution may reflect beluga responses to a changing climate, selecting warmer and more turbid areas. Our finding provides insight into current and evolving beluga habitat and habitat selection under a changing climate, which may help inform beluga management in the TNMPA.

Published
2022
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28. Test Results of the CERN HL-LHC Low-$\beta$ Quadrupole Short Models MQXFS3c and MQXFS4

Author

Mangiarotti, Franco, Bajas, Hugues, Ambrosio, Giorgio, Bajko, Marta, Bordini, Bernardo, Bourcey, Nicolas, Duda, Michal, Desbiolles, Vincent, Feuvrier, Jerome, Fleiter, Jerome, Bermudez, Susana Izquierdo, Chiuchiolo, Antonella, Devred, Arnaud, Ferracin, Paolo, Fiscarelli, Lucio, Mentink, Matthias, Nobrega, Alfred, Pepitone, Kevin, Ravaioli, Emmanuele, Schmalzle, Jesse, Todesco, Ezio, Perez, Juan Carlos, Vallone, Giorgio, Willering, Gerard, and Yu, Miao

Subjects
Nb3Sn, low beta quadrupole, quench, superconducting magnets, Condensed Matter Physics, Electrical and Electronic Engineering, Materials Engineering, General Physics
Abstract

For the high luminosity upgrade of the CERN large hadron collider, lower β∗ quadrupole magnets based on advanced Nb3Sn conductors will be installed on each side of the ATLAS and compact muon solenoid (CMS) experiment insertion zones. As part of the technological developments needed to achieve the required field gradient of 132.6 T/m within a 150-mm aperture, short length model magnets, named MQXFS, are tested both at the CERN SM18 and Fermilab test facilities. The model magnets rely on two types of Nb3Sn conductors (restack rod process (RRP) and powder-in-tube (PIT)) and on an innovative bladders and keys design to provide mechanical support against the Lorentz forces. In 2016 and 2017, the powering tests of the first two models MQXFS3 (RRP) and MQXFS5 (PIT) proved that nominal performance (16.5 kA) could be reached with excellent memory of the quench current after thermal cycle. However both magnets showed a slow training behavior with clear observations of voltage disturbances before the quench. Besides, only MQXFS5 could reach ultimate current (17.9 kA) whereas erratic behavior was observed on MQXFS3 due to conductor local degradation at the head of one of the coils. In 2018, this limiting coil was changed and the applied azimuthal prestress increased. While ultimate current could then be reached, no stable current could be maintained due to identified defect on the outer layer of the new coil. Finally the outcome of the test of the new model MQXFS4, featuring the final RRP conductors that will be used for the series production and variation on the inner layer quench heater designs are here reported in details.

Published
2019

29. Mechanical analysis of the Nb 3 Sn 11 T dipole short models for the High Luminosity Large Hadron Collider

Author

Izquierdo Bermudez, S, Nilsson, E, Bottura, L, Bourcey, N, Devred, A, Ferracin, P, Ferradas Troitino, S, Fiscarelli, L, Guinchard, M, Löffler, C, Mazet, J, Perez, JC, Prin, H, Savary, F, Sequeira Tavares, S, Vallone, G, and Willering, G

Subjects
high luminosity LHC, high field Nb3Sn magnet, 11T dipole, Condensed Matter Physics, Electrical and Electronic Engineering, Materials Engineering, General Physics
Abstract

For the Large Hadron Collider luminosity upgrade, two of the NbTi 8.3 T main bending dipoles will be replaced by two shorter Nb3Sn 11.2 T dipoles to create space for the installation of collimators in the dispersion suppression region. With the aim to verify the design features, several 2 m long 11 T models have been constructed and tested at CERN. During the fabrication and assembly of, so far, seven single and two double aperture short model magnets, several challenges were identified and tackled. These include reproducibility in coil fabrication and assembly procedure, as well as control of mechanical stresses in the conductor and surrounding structure. In order to limit coil over-compression and improve reproducibility, the cable insulation was re-optimized. In addition, a review of the collaring procedure of the 11 T magnet was launched with the goal of reducing the risk of conductor degradation due to excessive stress. In this paper, the main fabrication and assembly steps are described, including the description of the actions taken to resolve the identified weakness.

Published
2019

30. Test Results of the CERN HL-LHC Low-β Quadrupole Short Models MQXFS3c and MQXFS4

Author

Mangiarotti, F, Bajas, H, Ambrosio, G, Bajko, M, Bordini, B, Bourcey, N, Duda, M, Desbiolles, V, Feuvrier, J, Fleiter, J, Bermudez, SI, Chiuchiolo, A, Devred, A, Ferracin, P, Fiscarelli, L, Mentink, M, Nobrega, A, Pepitone, K, Ravaioli, E, Schmalzle, J, Todesco, E, Perez, JC, Vallone, G, Willering, G, and Yu, M

Subjects
Nb3Sn, low beta quadrupole, quench, superconducting magnets, Electrical and Electronic Engineering, Condensed Matter Physics, Materials Engineering, General Physics
Abstract

For the high luminosity upgrade of the CERN large hadron collider, lower β∗ quadrupole magnets based on advanced Nb3Sn conductors will be installed on each side of the ATLAS and compact muon solenoid (CMS) experiment insertion zones. As part of the technological developments needed to achieve the required field gradient of 132.6 T/m within a 150-mm aperture, short length model magnets, named MQXFS, are tested both at the CERN SM18 and Fermilab test facilities. The model magnets rely on two types of Nb3Sn conductors (restack rod process (RRP) and powder-in-tube (PIT)) and on an innovative bladders and keys design to provide mechanical support against the Lorentz forces. In 2016 and 2017, the powering tests of the first two models MQXFS3 (RRP) and MQXFS5 (PIT) proved that nominal performance (16.5 kA) could be reached with excellent memory of the quench current after thermal cycle. However both magnets showed a slow training behavior with clear observations of voltage disturbances before the quench. Besides, only MQXFS5 could reach ultimate current (17.9 kA) whereas erratic behavior was observed on MQXFS3 due to conductor local degradation at the head of one of the coils. In 2018, this limiting coil was changed and the applied azimuthal prestress increased. While ultimate current could then be reached, no stable current could be maintained due to identified defect on the outer layer of the new coil. Finally the outcome of the test of the new model MQXFS4, featuring the final RRP conductors that will be used for the series production and variation on the inner layer quench heater designs are here reported in details.

Published
2019

31. Mechanical analysis of the Nb3Sn 11 T dipole short models for the High Luminosity Large Hadron Collider

Author

Izquierdo Bermudez, S, Nilsson, E, Bottura, L, Bourcey, N, Devred, A, Ferracin, P, Ferradas Troitino, S, Fiscarelli, L, Guinchard, M, Löffler, C, Mazet, J, Perez, JC, Prin, H, Savary, F, Sequeira Tavares, S, Vallone, G, and Willering, G

Subjects
high luminosity LHC, high field Nb3Sn magnet, 11T dipole, General Physics, Condensed Matter Physics, Materials Engineering, Electrical and Electronic Engineering
Abstract

For the Large Hadron Collider luminosity upgrade, two of the NbTi 8.3 T main bending dipoles will be replaced by two shorter Nb3Sn 11.2 T dipoles to create space for the installation of collimators in the dispersion suppression region. With the aim to verify the design features, several 2 m long 11 T models have been constructed and tested at CERN. During the fabrication and assembly of, so far, seven single and two double aperture short model magnets, several challenges were identified and tackled. These include reproducibility in coil fabrication and assembly procedure, as well as control of mechanical stresses in the conductor and surrounding structure. In order to limit coil over-compression and improve reproducibility, the cable insulation was re-optimized. In addition, a review of the collaring procedure of the 11 T magnet was launched with the goal of reducing the risk of conductor degradation due to excessive stress. In this paper, the main fabrication and assembly steps are described, including the description of the actions taken to resolve the identified weakness.

Published
2019

35. Production and utilization of pseudocobalamin in marine Synechococcus cultures and communities.

Author

Bannon, Catherine C., Soto, Maria A., Rowland, Elden, Chen, Nan, Gleason, Anna, Devred, Emmanuel, LaRoche, Julie, and Bertrand, Erin M.

Subjects
SUPPLY & demand, VITAMIN B12, MICROBIAL communities, SYNECHOCOCCUS, LOW temperatures
Abstract

Cobalamin influences marine microbial communities because an exogenous source is required by most eukaryotic phytoplankton, and demand can exceed supply. Pseudocobalamin is a cobalamin analogue produced and used by most cyanobacteria but is not directly available to eukaryotic phytoplankton. Some microbes can remodel pseudocobalamin into cobalamin, but a scarcity of pseudocobalamin measurements impedes our ability to evaluate its importance for marine cobalamin production. Here, we perform simultaneous measurements of pseudocobalamin and methionine synthase (MetH), the key protein that uses it as a co‐factor, in Synechococcus cultures and communities. In Synechococcus sp. WH8102, pseudocobalamin quota decreases in low temperature (17°C) and low nitrogen to phosphorus ratio, while MetH did not. Pseudocobalamin and MetH quotas were influenced by culture methods and growth phase. Despite the variability present in cultures, we found a comparably consistent quota of 300 ± 100 pseudocobalamin molecules per cyanobacterial cell in the Northwest Atlantic Ocean, suggesting that cyanobacterial cell counts may be sufficient to estimate pseudocobalamin inventories in this region. This work offers insights into cellular pseudocobalamin metabolism, environmental and physiological conditions that may influence it, and provides environmental measurements to further our understanding of when and how pseudocobalamin can influence marine microbial communities. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Enhanced chlorophyll-a concentration in the wake of Sable Island, eastern Canada, revealed by two decades of satellite observations: a response to grey seal population dynamics?

Author

E. Devred, A. Hilborn, and C. E. den Heyer

Subjects
Ecology, QH540-549.5, Life, QH501-531, Geology, QE1-996.5
Abstract

Elevated surface chlorophyll-a (chl-a) concentration ([chl-a]), an index of phytoplankton biomass, has been previously observed and documented by remote sensing in the waters to the southwest of Sable Island (SI) on the Scotian Shelf in eastern Canada. Here, we present an analysis of this phenomenon using a 21-year time series of satellite-derived [chl-a], paired with information on the particle backscattering coefficient at 443 nm (bbp(443), a proxy for particle suspension) and the detritus/gelbstoff absorption coefficient at 443 nm (adg(443), a proxy to differentiate water masses and presence of dissolved organic matter) in an attempt to explain some possible mechanisms that lead to the increase in surface biomass in the surroundings of SI. We compared the seasonal cycle, 8 d climatology and seasonal trends of surface waters near SI to two control regions located both upstream and downstream of the island, away from terrigenous inputs. Application of the self-organising map (SOM) approach to the time series of satellite-derived [chl-a] over the Scotian Shelf revealed the annual spatio-temporal patterns around SI and, in particular, persistently high phytoplankton biomass during winter and spring in the leeward side of SI, a phenomenon that was not observed in the control boxes. In the vicinity of SI, a significant increase in [chl-a] and adg(443) during the winter months occurred at a rate twice that of the ones observed in the control boxes, while no significant trends were found for the other seasons. In addition to the increase in [chl-a] and adg(443) within the plume southwest of SI, the surface area of the plume itself expanded by a factor of 5 over the last 21 years. While the island mass effect (IME) explained the enhanced biomass around SI, we hypothesised that the large increase in [chl-a] over the last 21 years was partly due to an injection of nutrients by the island's grey seal colony, which has increased by 200 % during the same period. This contribution of nutrients from seals may sustain high phytoplankton biomass at a time of year when it is usually low following the fall bloom. A conceptual model was developed to estimate the standing stock of chl-a that can be sustained by the release of nitrogen (N) by seals. Comparison between satellite observations and model simulations showed a good temporal agreement between the increased abundance of seal on SI during the breeding season and the phytoplankton biomass increase during the winter. We found that about 20 % of chl-a standing stock increase over the last 21 years could be due to seal N fertilisation, the remaining being explained by climate forcing and oceanographic processes. Although without in situ measurements for ground truthing, the satellite data analysis provided evidence of the impact of marine mammals on lower trophic levels through a fertilisation mechanism that is coupled with the IME with potential implications for conservation and fisheries.

Published
2021
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39. Seasonal and decadal variations in absorption properties of phytoplankton and non-algal particulate matter in three oceanic regimes of the Northwest Atlantic

Author

Emmanuel Devred, Tim Perry, and Philippe Massicotte

Subjects
phytoplankton, absorption, chlorophyll-a concentration, phytoplankton apparent absorption wavelength (PAAW), Northwest Atlantic, time series analysis, Science, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract

Seasonal and inter-annual absorption properties of phytoplankton and non-algal particulate matter were studied in relation to phytoplankton biomass, as indexed by chlorophyll-a concentration, and presence of diatoms, as indexed by fucoxanthin concentration, using a 20-year time series of in situ data collected in the Northwest Atlantic. We found significant differences in the spatiotemporal variations of the bio-optical properties for three oceanic regimes: mesotrophic (Scotian Shelf), oligotrophic (Northwest Atlantic Basin, NAB), and subartic (Labrador Sea). The Scotian Shelf and NAB exhibited similar phenology with the spring and autumn blooms associated with low phytoplankton specific absorption, while only relatively high fucoxanthin concentration occurred in spring. The NAB showed a smaller seasonal variation than the Scotian Shelf in agreement with its oceanic conditions. The Labrador Sea showed a single phytoplankton bloom in spring followed by a continuous decrease in biomass the rest of the year. The relationship between phytoplankton absorption coefficient at 443 nm and chlorophyll-a concentration was consistent with other studies with coefficients that were region-dependent. Absorption by non-algal particulate matter remained between 5% and 60% of phytoplankton absorption with a mean of 15%. The slope of the non-algal particulate absorption varied with seasons and regions and appeared to depend on the trophic status with high values (i.e., up to 0.04) occurring during bloom conditions. We also introduced a new index, the phytoplankton apparent absorption wavelength (PAAW), a wavelength-weighted sum of absorption expressed in nanometers that provides information on the phytoplankton biomass and assemblage in a simple manner. Time series analysis of the PAAW revealed a decrease of this property in spring on the Scotian Shelf, NAB, and Labrador Sea and an increase in autumn on the Scotian Shelf and NAB, suggesting a shift in these ecosystems.

Published
2022
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42. Statistical analysis of the Nb3Sn strand production for the ITER toroidal field coils

Author

Vostner, A, Jewell, M, Pong, I, Sullivan, N, Devred, A, Bessette, D, Bevillard, G, Mitchell, N, Romano, G, and Zhou, C

Subjects
Manufacturing Engineering, Engineering, Condensed Matter Physics, Electrical and Electronic Engineering, Materials Engineering, General Physics, Materials engineering, Condensed matter physics
Abstract

The ITER toroidal field (TF) strand procurement initiated the largest Nb3Sn superconducting strand production hitherto. The industrial-scale production started in Japan in 2008 and finished in summer 2015. Six ITER partners (so-called Domestic Agencies, or DAs) are in charge of the procurement and involved eight different strand suppliers all over the world, of which four are using the bronze route (BR) process and four the internal-tin (IT) process. In total more than 500 tons have been produced including excess material covering losses during the conductor manufacturing process, in particular the cabling. The procurement is based on a functional specification where the main strand requirements like critical current, hysteresis losses, Cu ratio and residual resistance ratio are specified but not the strand production process or layout. This paper presents the analysis on the data acquired during the quality control (QC) process that was carried out to ensure the same conductor performance requirements are met by the different strand suppliers regardless of strand design. The strand QC is based on 100% billet testing and on applying statistical process control (SPC) limits. Throughout the production, samples adjacent to the strand pieces tested by the suppliers are cross-checked ('verified') by their respective DAs reference labs. The level of verification was lowered from 100% at the beginning of the procurement progressively to approximately 25% during the final phase of production. Based on the complete dataset of the TF strand production, an analysis of the SPC limits of the critical strand parameters is made and the related process capability indices are calculated. In view of the large-scale production and costs, key manufacturing parameters such as billet yield, number of breakages and piece-length distribution are also discussed. The results are compared among all the strand suppliers, focusing on the difference between BR and IT processes. Following the completion of the largest Nb3Sn strand production, our experience gained from monitoring the execution of the QC activities and from auditing the results from the measurements is summarised for future superconducting strand material procurement activities.

Published
2017

43. Towards MQXFB Series Coils

Author

Lusa, Nicholas, Devred, Arnaud, Troitino, Jose Ferradas, Bermudez, Susana Izquierdo, Milanese, Attilio, Quassolo, Penelope Matilde, Straarup, Simon, and Todesco, Ezio

Abstract

The cold powering test of the first two MQXFB prototype quadrupoles, the Nb3Sn inner triplet magnets to be installed in the HL-LHC, has found performance limitations. This prompted putting on hold the coil fabrication, to review in depth the full manufacturing process, while in parallel performing destructive inspections on selected coils. In particular, the post-mortem analysis of the limiting coil in MQXFBP1 identified a recurrent defect on top of the inner layer pole turn in the 2D cross-section, in correspondence to the titanium pole-to-pole transitions in the longitudinal direction. The next two magnets, MQXFBP3 and MQXFB02, reached the required performance for operation in the machine at 1.9 K. However, they still showed a limitation at 4.5 K, with a phenomenology similar to the one observed on MQXFBP1 and MQXFBP2. The review of the coil manufacturing process pointed to some improvement axes, which are being treated in a systematic manner. With the aim of addressing the potential root causes, the coil production gradually restarted, with transition coils, where additional measurements were carried out and selected changes in the procedure implemented. This article presents the challenges of fabricating 7.2-m-long accelerator quality Nb3Sn coils, together with the solutions specifically adopted for MQXFB, which could be instrumental also for future projects.

Published
2024
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44. Curved-Canted-Cosine-Theta (CCCT) Dipole Prototype Development at CERN

Author

Haziot, Ariel, Kirby, Glyn, Dallocchio, Alessandro, Devred, Arnaud, Foussat, Arnaud, Gentini, Luca, Mangiarotti, Franco J., Pentella, Mariano, Petrone, Carlo, Pincot, Francois-Olivier, Rigaud, Jean-Sebastien, and Guardia-Valenzuela, Jorge

Abstract

Due to its flexibility in generating advanced field harmonic corrections and potential for low cost compared to traditional designs, the Canted Cosine Theta (CCT) configuration is particularly interesting for compact particle accelerators and gantries for medical applications. This article presents the design of a curved demonstrator named Fusillo, a Canted Cosine Theta Nb-Ti dipole magnet that is being developed at CERN, featuring a large aperture of 236 mm, a small bending radius of 1 m, a bending angle of 90$^{\circ }$, and multi-harmonic field correction, with a 3.61 T conductor peak field. We detail the magnetic coil design, incorporating high-order magnetic field correction of the errors produced by the heavily curved coil, peak field reduction at the coil ends, the development of a new rope type cable, and the mechanical design and the development of the former that supports the coil and provides the curved shape. We also present the first results of a subscale model used to qualify the coil's former manufacturing process, the rope cable, the coil winding optimization, and the coil impregnation system.

Published
2024
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45. Proof-of-Principle of an Energy-Efficient, Iron-Dominated Electromagnet for Physics Experiments

Author

Devred, A., Ballarino, A., Bourcey, N., Mangiarotti, F., Milanese, A., and Petrone, C.

Abstract

A number of physics experiments call for the use of iron-dominated, normal-conducting electromagnets to produce moderate fields (2 T range) in a large gap or over a large volume. Although robust and reliable, these magnets require significant electrical power, in the MW range, and can thus be costly to operate, especially in DC mode. We report on the design and test of a superconducting, proof-of-principle demonstrator that makes use of technological developments carried out for the High Luminosity upgrade of the Large Hadron Collider at CERN (HL-LHC). The demonstrator includes a superconducting coil, wound from a MgB2 cable, and mounted inside an iron yoke with a 62 mm gap. As a first phase, the demonstrator was successfully tested in liquid helium at 4.5 K, generating a magnetic flux density of 1.95 T at a current of 5 kA. In a second phase, currently under preparation, the demonstrator will be tested in gaseous helium at 20 K. The design concepts of the demonstrator can be scaled up to large, iron-dominated electromagnets.

Published
2024
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46. Delineation of Eastern Beaufort Sea Sub-regions Using Self-Organizing Maps Applied to 17 Years of MODIS-Aqua Data

Author

Andrea Hilborn and Emmanuel Devred

Subjects
ocean colour, Beaufort Sea, chlorophyll-a concentration, suspended particulate matter, sea surface temperature, biogeochemical regions, Science, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract

Satellite observations are an integral component of long-term Arctic Ocean monitoring and help identifying changes resulting from climate warming. A Self-Organizing Maps (SOM) approach was applied to four-day composite satellite images of the Eastern Beaufort Sea (EBS) acquired by the MODerate resolution Imaging Spectroradiometer over the period 2003–2019. Using sea-surface temperature (SST), suspended particulate matter concentration (SPM) and chlorophyll-a concentration (Chl-a) as input the EBS was partitioned into six biogeochemical regions. The SOM approach revealed region-specific mean conditions and seasonal cycles for all properties, particularly for SPM and Chl-a. Three of the six regions, located on the continental shelf, had the highest SST, SPM and Chl-a with earlier maxima compared to the remaining three regions which comprised the shelf edge, Canada Basin and Amundsen Gulf. While mean and maximum SST did not exhibit significant trends over the 17 years of observations, the annual maximum SST in Amundsen Gulf was reached significantly earlier in recent years compared to the start of the time series. With the exception of Amundsen Gulf, sea-ice concentration (SIC) derived from microwave satellites declined throughout the study area; monthly trends showed dramatic SIC declines in regions on the shelf during May and June, and in Canada Basin during August. Correlation analysis of properties within and between regions showed that SST and SIC were driven by large scale processes while SPM and Chl-a showed regional features. SST and Chl-a in the regions nearest the Mackenzie River showed a strong relationship during seasonal warming. The SOM approach, applied to 17 years of satellite data, revealed spatially distinct marine units with unique characteristics, emphasizing the need for regional considerations when assessing the impact of climate warming in the Arctic Ocean.

Published
2022
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47. Tear nanoDSF Denaturation Profile Is Predictive of Glaucoma

Author

Viktoriia E. Baksheeva, Veronika V. Tiulina, Elena N. Iomdina, Sergey Yu. Petrov, Olga M. Filippova, Nina Yu. Kushnarevich, Elena A. Suleiman, Rémi Eyraud, François Devred, Marina V. Serebryakova, Natalia G. Shebardina, Dmitry V. Chistyakov, Ivan I. Senin, Vladimir A. Mitkevich, Philipp O. Tsvetkov, and Evgeni Yu. Zernii

Subjects
biomarker, diagnostic, glaucoma, POAG, tear fluid, tear proteins, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Primary open-angle glaucoma (POAG) is a frequent blindness-causing neurodegenerative disorder characterized by optic nerve and retinal ganglion cell damage most commonly due to a chronic increase in intraocular pressure. The preservation of visual function in patients critically depends on the timeliness of detection and treatment of the disease, which is challenging due to its asymptomatic course at early stages and lack of objective diagnostic approaches. Recent studies revealed that the pathophysiology of glaucoma includes complex metabolomic and proteomic alterations in the eye liquids, including tear fluid (TF). Although TF can be collected by a non-invasive procedure and may serve as a source of the appropriate biomarkers, its multi-omics analysis is technically sophisticated and unsuitable for clinical practice. In this study, we tested a novel concept of glaucoma diagnostics based on the rapid high-performance analysis of the TF proteome by differential scanning fluorimetry (nanoDSF). An examination of the thermal denaturation of TF proteins in a cohort of 311 ophthalmic patients revealed typical profiles, with two peaks exhibiting characteristic shifts in POAG. Clustering of the profiles according to peaks maxima allowed us to identify glaucoma in 70% of cases, while the employment of artificial intelligence (machine learning) algorithms reduced the amount of false-positive diagnoses to 13.5%. The POAG-associated alterations in the core TF proteins included an increase in the concentration of serum albumin, accompanied by a decrease in lysozyme C, lipocalin-1, and lactotransferrin contents. Unexpectedly, these changes were not the only factor affecting the observed denaturation profile shifts, which considerably depended on the presence of low-molecular-weight ligands of tear proteins, such as fatty acids and iron. Overall, we recognized the TF denaturation profile as a novel biomarker of glaucoma, which integrates proteomic, lipidomic, and metallomic alterations in tears, and monitoring of which could be adapted for rapid non-invasive screening of the disease in a clinical setting.

Published
2023
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50. Physical controls and ecological implications of the timing of the spring phytoplankton bloom on the Newfoundland and Labrador shelf.

Author

Cyr, Frédéric, Lewis, Keith, Bélanger, David, Regular, Paul, Clay, Stephanie, and Devred, Emmanuel

Subjects
ALGAL blooms, SPRING, CALANUS finmarchicus, MARINE zooplankton, CLIMATE change, PHYTOPLANKTON, FOOD chains
Abstract

The timing of spring phytoplankton blooms is crucial to many species that have adapted their development to benefit from the enhanced feeding opportunity they offer. Any change to their timing may affect the productivity of an entire ecosystem. This study explores the relationship between the ocean climate, the timing of the spring bloom and the secondary production on the Newfoundland and Labrador shelf. It is found that over interannual cycles, the ocean climate is significantly correlated with the timing of the bloom and the abundance of Calanus finmarchicus, a key zooplankton species for the ecosystem. It also appears that the spring bloom is initiated by the onset of ocean re‐stratification following winter mixing. Understanding how annual variation in climate relates to the timing of the spring bloom and zooplankton abundance, that is, the base of the marine food web, can inform the development of ecosystem‐informed models for higher trophic levels. [ABSTRACT FROM AUTHOR]

Published
2024
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