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1. Intravenous Odatroltide for Acute Ischemic Stroke Within 24 Hours of Onset: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

Author: Chao AC, Lee TH, Pettigrew LC, Hannawi Y, Huang HY, Chi NF, Chan L, Chen PL, and Devlin T
Subjects: lt3001, ischemic stroke, rtpa, Therapeutics. Pharmacology, RM1-950
Abstract: A-Ching Chao,1,2 Tsong-Hai Lee,3 Luther C Pettigrew,4 Yousef Hannawi,5 Hung-Yu Huang,6 Nai-Fang Chi,7,8 Lung Chan,9,10 Po-Lin Chen,11 Thomas Devlin12,13 1Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 2College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Stroke Center and Department of Neurology, Linkou Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan; 4Department of Neurology, University of Kentucky Chandler Medical Center, Lexington, KY, USA; 5Division of Cerebrovascular Diseases and Neurocritical Care, Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; 6Department of Neurology, China Medical University Hospital, Taichung, Taiwan; 7School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; 8Division of Cerebrovascular Diseases, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; 9Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; 10Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 11Division of Neurology, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan; 12CHI Memorial Neuroscience Institute, Chattanooga, TN, USA; 13Department of Neurology, Morehouse School of Medicine, Atlanta, GA, USACorrespondence: Thomas Devlin, Chattanooga Center for Neurological Research, 725 Glenwood Drive, Suite 880-A, Chattanooga, TN, 37404, USA, Email devlinmdphd@gmail.comPurpose: Odatroltide (LT3001), a novel small synthetic peptide molecule designed to recanalize occluded blood vessels and reduce reperfusion injury, is safe and efficacious in multiple embolic stroke animal models. This study aimed to investigate the safety and tolerability of intravenous administration of odatroltide in patients with acute ischemic stroke within 24 hours of onset.Patients and Methods: Patients with National Institutes of Health Stroke Scale (NIHSS 4– 30) who were untreated with intravenous thrombolysis or endovascular thrombectomy were randomized (2:1) to receive a single dose of odatroltide (0.025 mg/kg) or placebo within 24 hours of stroke symptom onset. The primary safety outcome was symptomatic intracranial hemorrhage (sICH) occurrence within 36 hours.Results: Twenty-four patients were enrolled and randomized; of these 16 and 8 received intravenous odatroltide infusion and placebo, respectively. sICH did not occur in both groups, and other safety measures were comparable between the groups. The rate of excellent functional outcome (modified Rankin Scale score, 0– 1, at 90 days) was 21% and 14% in the odatroltide and placebo groups, respectively. Furthermore, 47% and 14% of patients in the odatroltide and placebo groups, respectively, showed major neurological improvement (NIHSS improvement ≥ 4 points from baseline to 30 days). Among the 9 odatroltide-treated patients with baseline NIHSS ≥ 6, 78% showed major neurological improvement.Conclusion: Compared with placebo, treatment with intravenous odatroltide within 24 hours following onset of ischemic stroke appears to be safe and may be associated with better neurological and functional outcomes. However, the efficacy and safety of odatroltide requires further confirmation in the next phase of clinical trials.Clinical Trial Registration: Clinicaltrials.gov identifier: NCT04091945.Keywords: LT3001, ischemic stroke, rtPA
Published: 2024

2. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Author: Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, Wechsler, L, Streib, S, Rangaraju, S, Campbell, D, Rocha, M, Gulati, D, Krings, T, Kalman, L, Cayley, A, Williams, J, Wiegner, R, Casaubon, LK, Jaigobin, C, del Campo, JM, Elamin, E, Schaafsma, JD, Agid, R, Farb, R, ter Brugge, K, Sapkoda, BL, Baxter, BW, Barton, K, Knox, A, Porter, A, Sirelkhatim, A, Devlin, T, Dellinger, C, Pitiyanuvath, N, Patterson, J, Nichols, J, Quarfordt, S, Calvert, J, Hawk, H, Fanale, C, Bitner, A, Novak, A, Huddle, D, Bellon, R, Loy, D, Wagner, J, Chang, I, Lampe, E, Spencer, B, Pratt, R, Bartt, R, Shine, S, Dooley, G, Nguyen, T, Whaley, M, McCarthy, K, Teitelbaum, J, Poon, W, Campbell, N, Cortes, M, Lum, C, Shamloul, R, Robert, S, Stotts, G, Shamy, M, Steffenhagen, N, Blacquiere, D, Hogan, M, AlHazzaa, M, Basir, G, Lesiuk, H, Iancu, D, Santos, M, Choe, H, Weisman, DC, Jonczak, K, Blue-Schaller, A, Shah, Q, MacKenzie, L, Klein, B, Kulandaivel, K, Kozak, O, Gzesh, DJ, Harris, LJ, Khoury, JS, Mandzia, J, Pelz, D, Crann, S, Fleming, L, Hesser, K, Beauchamp, B, Amato-Marzialli, B, Boulton, M, Lopez- Ojeda, P, Sharma, M, Lownie, S, Chan, R, Swartz, R, Howard, P, Golob, D, Gladstone, D, Boyle, K, Boulos, M, Hopyan, J, Yang, V, Da Costa, L, Holmstedt, CA, Turk, AS, Navarro, R, Jauch, E, Ozark, S, Turner, R, Phillips, S, Shankar, J, Jarrett, J, Gubitz, G, Maloney, W, Vandorpe, R, Schmidt, M, Heidenreich, J, Hunter, G, Kelly, M, Whelan, R, Peeling, L, Burns, PA, Hunter, A, Wiggam, I, Kerr, E, Watt, M, Fulton, A, Gordon, P, Rennie, I, Flynn, P, Smyth, G, O'Leary, S, Gentile, N, Linares, G, McNelis, P, Erkmen, K, Katz, P, Azizi, A, Weaver, M, Jungreis, C, Faro, S, Shah, P, Reimer, H, Kalugdan, V, Saposnik, G, Bharatha, A, Li, Y, Kostyrko, P, Marotta, T, Montanera, W, Sarma, D, Selchen, D, Spears, J, Heo, JH, Jeong, K, Kim, DJ, Kim, BM, Kim, YD, Song, D, Lee, K-J, Yoo, J, Bang, OY, Rho, S, Lee, J, Jeon, P, Kim, KH, Cha, J, Kim, SJ, Ryoo, S, Lee, MJ, Sohn, S-I, Kim, C-H, Ryu, H-G, Hong, J-H, Chang, H-W, Lee, C-Y, Rha, J, Davis, Stephen M, Donnan, Geoffrey A, Campbell, Bruce CV, Mitchell, Peter J, Churilov, Leonid, Yan, Bernard, Dowling, Richard, Yassi, Nawaf, Oxley, Thomas J, Wu, Teddy Y, Silver, Gabriel, McDonald, Amy, McCoy, Rachael, Kleinig, Timothy J, Scroop, Rebecca, Dewey, Helen M, Simpson, Marion, Brooks, Mark, Coulton, Bronwyn, Krause, Martin, Harrington, Timothy J, Steinfort, Brendan, Faulder, Kenneth, Priglinger, Miriam, Day, Susan, Phan, Thanh, Chong, Winston, Holt, Michael, Chandra, Ronil V, Ma, Henry, Young, Dennis, Wong, Kitty, Wijeratne, Tissa, Tu, Hans, Mackay, Elizabeth, Celestino, Sherisse, Bladin, Christopher F, Loh, Poh Sien, Gilligan, Amanda, Ross, Zofia, Coote, Skye, Frost, Tanya, Parsons, Mark W, Miteff, Ferdinand, Levi, Christopher R, Ang, Timothy, Spratt, Neil, Kaauwai, Lara, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Barber, P. Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, SJ, Lescher, S, Braun, H, Dehkharghani, S, Belagaje, SR, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, DK, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, JS, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, M, Göricke, S, Ringlestein, A, Wanke, I, Mönninghoff, C, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, WJ, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, Hussain, MS, Russman, A, Hui, F, Wisco, D, Uchino, K, Khawaja, Z, Katzan, I, Toth, G, Cheng-Ching, E, Bain, M, Man, S, Farrag, A, George, P, John, S, Shankar, L, Drofa, A, Dahlgren, R, Bauer, A, Itreat, A, Taqui, A, Cerejo, R, Richmond, A, Ringleb, P, Bendszus, M, Möhlenbruch, M, Reiff, T, Amiri, H, Purrucker, J, Herweh, C, Pham, M, Menn, O, Ludwig, I, Acosta, I, Villar, C, Morgan, W, Sombutmai, C, Hellinger, F, Allen, E, Bellew, M, Gandhi, R, Bonwit, E, Aly, J, Ecker, RD, Seder, D, Morris, J, Skaletsky, M, Belden, J, Baker, C, Connolly, LS, Papanagiotou, P, Roth, C, Kastrup, A, Politi, M, Brunner, F, Alexandrou, M, Merdivan, H, Ramsey, C, Given II, C, Renfrow, S, Deshmukh, V, Sasadeusz, K, Vincent, F, Thiesing, JT, Putnam, J, Bhatt, A, Kansara, A, Caceves, D, Lowenkopf, T, Yanase, L, Zurasky, J, Dancer, S, Freeman, B, Scheibe-Mirek, T, Robison, J, Roll, J, Clark, D, Rodriguez, M, Fitzsimmons, B-FM, Zaidat, O, Lynch, JR, Lazzaro, M, Larson, T, Padmore, L, Das, E, Farrow-Schmidt, A, Hassan, A, Tekle, W, Cate, C, Jansen, O, Cnyrim, C, Wodarg, F, Wiese, C, Binder, A, Riedel, C, Rohr, A, Lang, N, Laufs, H, Krieter, S, Remonda, L, Diepers, M, Añon, J, Nedeltchev, K, Kahles, T, Biethahn, S, Lindner, M, Chang, V, Gächter, C, Esperon, C, Guglielmetti, M, Arenillas Lara, JF, Martínez Galdámez, M, Calleja Sanz, AI, Cortijo Garcia, E, Garcia Bermejo, P, Perez, S, Mulero Carrillo, P, Crespo Vallejo, E, Ruiz Piñero, M, Lopez Mesonero, L, Reyes Muñoz, FJ, Brekenfeld, C, Buhk, J-H, Krützelmann, A, Thomalla, G, Cheng, B, Beck, C, Hoppe, J, Goebell, E, Holst, B, Grzyska, U, Wortmann, G, Starkman, S, Duckwiler, G, Jahan, R, Rao, N, Sheth, S, Ng, K, Noorian, A, Szeder, V, Nour, M, McManus, M, Huang, J, Tarpley, J, Tateshima, S, Gonzalez, N, Ali, L, Liebeskind, D, Hinman, J, Calderon-Arnulphi, M, Liang, C, Guzy, J, Koch, S, DeSousa, K, Gordon-Perue, G, Elhammady, M, Peterson, E, Pandey, V, Dharmadhikari, S, Khandelwal, P, Malik, A, Pafford, R, Gonzalez, P, Ramdas, K, Andersen, G, Damgaard, D, Von Weitzel-Mudersbach, P, Simonsen, C, Ruiz de Morales Ayudarte, N, Poulsen, M, Sørensen, L, Karabegovich, S, Hjørringgaard, M, Hjort, N, Harbo, T, Sørensen, K, Deshaies, E, Padalino, D, Swarnkar, A, Latorre, JG, Elnour, E, El-Zammar, Z, Villwock, M, Farid, H, Balgude, A, Cross, L, Hansen, K, Holtmannspötter, M, Kondziella, D, Hoejgaard, J, Taudorf, S, Soendergaard, H, Wagner, A, Cronquist, M, Stavngaard, T, Cortsen, M, Krarup, LH, Hyldal, T, Haring, H-P, Guggenberger, S, Hamberger, M, Trenkler, J, Sonnberger, M, Nussbaumer, K, Dominger, C, Bach, E, Jagadeesan, BD, Taylor, R, Kim, J, Shea, K, Tummala, R, Zacharatos, H, Sandhu, D, Ezzeddine, M, Grande, A, Hildebrandt, D, Miller, K, Scherber, J, Hendrickson, A, Jumaa, M, Zaidi, S, Hendrickson, T, Snyder, V, Killer-Oberpfalzer, M, Mutzenbach, J, Weymayr, F, Broussalis, E, Stadler, K, Jedlitschka, A, Malek, A, Mueller-Kronast, N, Beck, P, Martin, C, Summers, D, Day, J, Bettinger, I, Holloway, W, Olds, K, Arkin, S, Akhtar, N, Boutwell, C, Crandall, S, Schwartzman, M, Weinstein, C, Brion, B, Prothmann, S, Kleine, J, Kreiser, K, Boeckh-Behrens, T, Poppert, H, Wunderlich, S, Koch, ML, Biberacher, V, Huberle, A, Gora-Stahlberg, G, Knier, B, Meindl, T, Utpadel-Fischler, D, Zech, M, Kowarik, M, Seifert, C, Schwaiger, B, Puri, A, Hou, S, Wakhloo, A, Moonis, M, Henninger, N, Goddeau, R, Massari, F, Minaeian, A, Lozano, JD, Ramzan, M, Stout, C, Patel, A, Tunguturi, A, Onteddu, S, Carandang, R, Howk, M, Ribó, M, Sanjuan, E, Rubiera, M, Pagola, J, Flores, A, Muchada, M, Meler, P, Huerga, E, Gelabert, S, Coscojuela, P, Tomasello, A, Rodriguez, D, Santamarina, E, Maisterra, O, Boned, S, Seró, L, Rovira, A, Molina, CA, Millán, M, Muñoz, L, Pérez de la Ossa, N, Gomis, M, Dorado, L, López-Cancio, E, Palomeras, E, Munuera, J, García Bermejo, P, Remollo, S, Castaño, C, García-Sort, R, Cuadras, P, Puyalto, P, Hernández-Pérez, M, Jiménez, M, Martínez-Piñeiro, A, Lucente, G, Dávalos, A, Chamorro, A, Urra, X, Obach, V, Cervera, A, Amaro, S, Llull, L, Codas, J, Balasa, M, Navarro, J, Ariño, H, Aceituno, A, Rudilosso, S, Renu, A, Macho, JM, San Roman, L, Blasco, J, López, A, Macías, N, Cardona, P, Quesada, H, Rubio, F, Cano, L, Lara, B, de Miquel, MA, Aja, L, Serena, J, Cobo, E, Albers, Gregory W, Lees, Kennedy R, Arenillas, J, Roberts, R, Al-Ajlan, F, Zimmel, L, Patel, S, Martí-Fàbregas, J, Salvat-Plana, M, Bracard, S, Ducrocq, Xavier, Anxionnat, René, Baillot, Pierre-Alexandre, Barbier, Charlotte, Derelle, Anne-Laure, Lacour, Jean-Christophe, Richard, Sébastien, Samson, Yves, Sourour, Nader, Baronnet-Chauvet, Flore, Clarencon, Frédéric, Crozier, Sophie, Deltour, Sandrine, Di Maria, Federico, Le Bouc, Raphael, Leger, Anne, Mutlu, Gurkan, Rosso, Charlotte, Szatmary, Zoltan, Yger, Marion, Zavanone, Chiara, Bakchine, Serge, Pierot, Laurent, Caucheteux, Nathalie, Estrade, Laurent, Kadziolka, Krzysztof, Leautaud, Alexandre, Renkes, Céline, Serre, Isabelle, Desal, Hubert, Guillon, Benoît, Boutoleau-Bretonniere, Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, Bourgois, Nathalie, Cornut-Chauvinc, Catherine, Ferrier, Anna, Gabrillargues, Jean, Jean, Betty, Marques, Anna-Raquel, Vitello, Nicolas, Detante, Olivier, Barbieux, Marianne, Boubagra, Kamel, Favre Wiki, Isabelle, Garambois, Katia, Tahon, Florence, Ashok, Vasdev, Coskun, Oguzhan, Rodesch, Georges, Lapergue, Bertrand, Bourdain, Frédéric, Evrard, Serge, Graveleau, Philippe, Decroix, Jean Pierre, Wang, Adrien, Sellal, François, Ahle, Guido, Carelli, Gabriela, Dugay, Marie-Hélène, Gaultier, Claude, Lebedinsky, Ariel Pablo, Lita, Lavinia, Musacchio, Raul Mariano, Renglewicz-Destuynder, Catherine, Tournade, Alain, Vuillemet, Françis, Montoro, Francisco Macian, Mounayer, Charbel, Faugeras, Frederic, Gimenez, Laetitia, Labach, Catherine, Lautrette, Géraldine, Denier, Christian, Saliou, Guillaume, Chassin, Olivier, Dussaule, Claire, Melki, Elsa, Ozanne, Augustin, Puccinelli, Francesco, Sachet, Marina, Sarov, Mariana, Bonneville, Jean-François, Moulin, Thierry, Biondi, Alessandra, De Bustos Medeiros, Elisabeth, Vuillier, Fabrice, Courtheoux, Patrick, Viader, Fausto, Apoil-Brissard, Marion, Bataille, Mathieu, Bonnet, Anne-Laure, Cogez, Julien, Touze, Emmanuel, Leclerc, Xavier, Leys, Didier, Aggour, Mohamed, Aguettaz, Pierre, Bodenant, Marie, Cordonnier, Charlotte, Deplanque, Dominique, Girot, Marie, Henon, Hilde, Kalsoum, Erwah, Lucas, Christian, Pruvo, Jean-Pierre, Zuniga, Paolo, Arquizan, Caroline, Costalat, Vincent, Machi, Paolo, Mourand, Isabelle, Riquelme, Carlos, Bounolleau, Pierre, Arteaga, Charles, Faivre, Anthony, Bintner, Marc, Tournebize, Patrice, Charlin, Cyril, Darcel, Françoise, Gauthier-Lasalarie, Pascale, Jeremenko, Marcia, Mouton, Servane, Zerlauth, Jean-Baptiste, Lamy, Chantal, Hervé, Deramond, Hassan, Hosseini, Gaston, André, Barral, Francis-Guy, Garnier, Pierre, Beaujeux, Rémy, Wolff, Valérie, Herbreteau, Denis, Debiais, Séverine, Murray, Alicia, Ford, Gary, Muir, Keith W, White, Philip, Clifton, Andy, Freeman, Janet, Ford, Ian, Markus, Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Campbell, Bruce C V, Majoie, Charles B L M, Menon, Bijoy K, van Zwam, Wim H, van Oostenbrugge, Robert J, Demchuk, Andrew M, Guillemin, Francis, Dávalos, Antoni, Butcher, Kenneth S, Cherifi, Aboubaker, Marquering, Henk A, Macho Fernández, Juan M, Oppenheim, Catherine, Roos, Yvo B W E M, Shankar, Jai, Lingsma, Hester, Hernández-Pérez, María, Bharatha, Aditya, Levy, Elad I, Soudant, Marc, Aja, Lucia, Krings, Timo, Tisserand, Marie, San Román, Luis, Tomasello, Alejandro, Brown, Scott, Liebeskind, David S, Bracard, Serge, Dippel, Diederik W J, Jovin, Tudor G, and Hill, Michael D
Published: 2019
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3. Combining Holland tropical cyclone and global atmospheric winds, recent experience in Western Australia

Author: Australasian Port and Harbour Conference (16th : 2017 : Cairns, Qld.), Devlin, T, Smith, M, and McConochie, J
Published: 2017

4. Search for First-Generation Scalar Leptoquarks in $\bm{p \bar{p}}$ collisions at $\sqrt{s}$=1.96 TeV

Author: The CDF Collaboration, Acosta, D., Adelman, J., Affolder, T., Akimoto, T., Albrow, M. G., Ambrose, D., Amerio, S., Amidei, D., Anastassov, A., Anikeev, K., Annovi, A., Antos, J., Aoki, M., Apollinari, G., Arisawa, T., Arguin, J-F., Artikov, A., Ashmanskas, W., Attal, A., Azfar, F., Azzi-Bacchetta, P., Bacchetta, N., Bachacou, H., Badgett, W., Barbaro-Galtieri, A., Barker, G. J., Barnes, V. E., Barnett, B. A., Baroiant, S., Bauer, G., Bedeschi, F., Behari, S., Belforte, S., Bellettini, G., Bellinger, J., Belloni, A., Ben-Haim, E., Benjamin, D., Beretvas, A., Berry, T., Bhatti, A., Binkley, M., Bisello, D., Bishai, M., Blair, R. E., Blocker, C., Bloom, K., Blumenfeld, B., Bocci, A., Bodek, A., Bolla, G., Bolshov, A., Bortoletto, D., Boudreau, J., Bourov, S., Brau, B., Bromberg, C., Brubaker, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Bussey, P., Byrum, K. L., Cabrera, S., Campanelli, M., Campbell, M., Canelli, F., Canepa, A., Casarsa, M., Carlsmith, D., Carosi, R., Carron, S., Cavalli-Sforza, M., Castro, A., Catastini, P., Cauz, D., Cerri, A., Cerrito, L., Chapman, J., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Chlebana, F., Cho, I., Cho, K., Chokheli, D., Chou, J. P., Chuang, S., Chung, K., Chung, W-H., Chung, Y. S., Cijliak, M., Ciobanu, C. I., Ciocci, M. A., Clark, A. G., Clark, D., Coca, M., Connolly, A., Convery, M., Conway, J., Cooper, B., Copic, K., Cordelli, M., Cortiana, G., Cranshaw, J., Cuevas, J., Cruz, A., Culbertson, R., Currat, C., Cyr, D., Dagenhart, D., DaRonco, S., D'Auria, S., deBarbaro, P., DeCecco, S., Deisher, A., DeLentdecker, G., Dell'Orso, M., Demers, S., Demortier, L., Deninno, M., DePedis, D., Derwent, P. F., Devlin, T., Dionisi, C., Dittmann, J. R., DiTuro, P., Dörr, C., Dominguez, A., Donati, S., Donega, M., Donini, J., D'Onofrio, M., Dorigo, T., Ebina, K., Efron, J., Ehlers, J., Erbacher, R., Erdmann, M., Errede, D., Errede, S., Eusebi, R., Fang, H-C., Farrington, S., Fedorko, I., Fedorko, W. T., Feild, R. G., Feindt, M., Fernandez, J. P., Field, R. D., Flanagan, G., Flores-Castillo, L. R., Foland, A., Forrester, S., Foster, G. W., Franklin, M., Freeman, J. C., Fujii, Y., Furic, I., Gajjar, A., Gallinaro, M., Galyardt, J., Garcia-Sciveres, M., Garfinkel, A. F., Gay, C., Gerberich, H., Gerdes, D. W., Gerchtein, E., Giagu, S., Giannetti, P., Gibson, A., Gibson, K., Ginsburg, C., Giolo, K., Giordani, M., Giunta, M., Giurgiu, G., Glagolev, V., Glenzinski, D., Gold, M., Goldschmidt, N., Goldstein, D., Goldstein, J., Gomez, G., Gomez-Ceballos, G., Goncharov, M., González, O., Gorelov, I., Goshaw, A. T., Gotra, Y., Goulianos, K., Gresele, A., Griffiths, M., Grosso-Pilcher, C., Grundler, U., GuimaraesdaCosta, J., Haber, C., Hahn, K., Hahn, S. R., Halkiadakis, E., Hamilton, A., Han, B-Y., Handler, R., Happacher, F., Hara, K., Hare, M., Harr, R. F., Harris, R. M., Hartmann, F., Hatakeyama, K., Hauser, J., Hays, C., Hayward, H., Heinemann, B., Heinrich, J., Hennecke, M., Herndon, M., Hill, C., Hirschbuehl, D., Hocker, A., Hoffman, K. D., Holloway, A., Hou, S., Houlden, M. A., Huffman, B. T., Huang, Y., Hughes, R. E., Huston, J., Ikado, K., Incandela, J., Introzzi, G., Iori, M., Ishizawa, Y., Issever, C., Ivanov, A., Iwata, Y., Iyutin, B., James, E., Jang, D., Jayatilaka, B., Jeans, D., Jensen, H., Jeon, E. J., Jones, M., Joo, K. K., Jun, S. Y., Junk, T., Kamon, T., Kang, J., KaragozUnel, M., Karchin, P. E., Kato, Y., Kemp, Y., Kephart, R., Kerzel, U., Khotilovich, V., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, M. S., Kim, S. B., Kim, S. H., Kim, Y. K., Kirby, M., Kirsch, L., Klimenko, S., Klute, M., Knuteson, B., Ko, B. R., Kobayashi, H., Kong, D. J., Kondo, K., Konigsberg, J., Kordas, K., Korn, A., Korytov, A., Kotwal, A. V., Kovalev, A., Kraus, J., Kravchenko, I., Kreymer, A., Kroll, J., Kruse, M., Krutelyov, V., Kuhlmann, S. E., Kwang, S., Laasanen, A. T., Lai, S., Lami, S., Lammel, S., Lancaster, M., Lander, R., Lannon, K., Lath, A., Latino, G., Lazzizzera, I., Lecci, C., LeCompte, T., Lee, J., Lee, S. W., Lefèvre, R., Leonardo, N., Leone, S., Levy, S., Lewis, J. D., Li, K., Lin, C., Lin, C. S., Lindgren, M., Lipeles, E., Liss, T. M., Lister, A., Litvintsev, D. O., Liu, T., Liu, Y., Lockyer, N. S., Loginov, A., Loreti, M., Loverre, P., Lu, R-S., Lucchesi, D., Lujan, P., Lukens, P., Lungu, G., Lyons, L., Lys, J., Lysak, R., Lytken, E., MacQueen, D., Madrak, R., Maeshima, K., Maksimovic, P., Manca, G., Margaroli, F., Marginean, R., Marino, C., Martin, A., Martin, M., Martin, V., Martínez, M., Maruyama, T., Matsunaga, H., Mattson, M., Mazzanti, P., McFarland, K. S., McGivern, D., McIntyre, P. M., McNamara, P., McNulty, R., Mehta, A., Menzemer, S., Menzione, A., Merkel, P., Mesropian, C., Messina, A., Miao, T., Miladinovic, N., Miles, J., Miller, L., Miller, R., Miller, J. S., Mills, C., Miquel, R., Miscetti, S., Mitselmakher, G., Miyamoto, A., Moggi, N., Mohr, B., Moore, R., Morello, M., MovillaFernandez, P. A., Muelmenstaedt, J., Mukherjee, A., Mulhearn, M., Muller, T., Mumford, R., Munar, A., Murat, P., Nachtman, J., Nahn, S., Nakano, I., Napier, A., Napora, R., Naumov, D., Necula, V., Nielsen, J., Nelson, T., Neu, C., Neubauer, M. S., Nigmanov, T., Nodulman, L., Norniella, O., Ogawa, T., Oh, S. H., Oh, Y. D., Ohsugi, T., Okusawa, T., Oldeman, R., Orava, R., Orejudos, W., Osterberg, K., Pagliarone, C., Palencia, E., Paoletti, R., Papadimitriou, V., Paramonov, A. A., Pashapour, S., Patrick, J., Pauletta, G., Paulini, M., Paus, C., Pellett, D., Penzo, A., Phillips, T. J., Piacentino, G., Piedra, J., Pitts, K. T., Plager, C., Pondrom, L., Pope, G., Portell, X., Poukhov, O., Pounder, N., Prakoshyn, F., Pronko, A., Proudfoot, J., Ptohos, F., Punzi, G., Rademacker, J., Rahaman, M. A., Rakitine, A., Rappoccio, S., Ratnikov, F., Ray, H., Reisert, B., Rekovic, V., Renton, P., Rescigno, M., Rimondi, F., Rinnert, K., Ristori, L., Robertson, W. J., Robson, A., Rodrigo, T., Rolli, S., Roser, R., Rossin, R., Rott, C., Russ, J., Rusu, V., Ruiz, A., Ryan, D., Saarikko, H., Sabik, S., Safonov, A., Denis, R. St., Sakumoto, W. K., Salamanna, G., Saltzberg, D., Sanchez, C., Santi, L., Sarkar, S., Sato, K., Savard, P., Savoy-Navarro, A., Schlabach, P., Schmidt, E. E., Schmidt, M. P., Schmitt, M., Schwarz, T., Scodellaro, L., Scott, A. L., Scribano, A., Scuri, F., Sedov, A., Seidel, S., Seiya, Y., Semenov, A., Semeria, F., Sexton-Kennedy, L., Sfiligoi, I., Shapiro, M. D., Shears, T., Shepard, P. F., Sherman, D., Shimojima, M., Shochet, M., Shon, Y., Shreyber, I., Sidoti, A., Sill, A., Sinervo, P., Sisakyan, A., Sjolin, J., Skiba, A., Slaughter, A. J., Sliwa, K., Smirnov, D., Smith, J. R., Snider, F. D., Snihur, R., Soderberg, M., Soha, A., Somalwar, S. V., Spalding, J., Spezziga, M., Spinella, F., Squillacioti, P., Stadie, H., Stanitzki, M., Stelzer, B., Stelzer-Chilton, O., Stentz, D., Strologas, J., Stuart, D., Suh, J. S., Sukhanov, A., Sumorok, K., Sun, H., Suzuki, T., Taffard, A., Tafirout, R., Takano, H., Takashima, R., Takeuchi, Y., Takikawa, K., Tanaka, M., Tanaka, R., Tanimoto, N., Tecchio, M., Teng, P. K., Terashi, K., Tesarek, R. J., Tether, S., Thom, J., Thompson, A. S., Thomson, E., Tipton, P., Tiwari, V., Tkaczyk, S., Toback, D., Tollefson, K., Tomura, T., Tonelli, D., Tönnesmann, M., Torre, S., Torretta, D., Tourneur, S., Trischuk, W., Tsuchiya, R., Tsuno, S., Tsybychev, D., Turini, N., Ukegawa, F., Unverhau, T., Uozumi, S., Usynin, D., Vacavant, L., Vaiciulis, A., Varganov, A., VejcikIII, S., Velev, G., Veszpremi, V., Veramendi, G., Vickey, T., Vidal, R., Vila, I., Vilar, R., Vollrath, I., Volobouev, I., vonderMey, M., Wagner, P., Wagner, R. G., Wagner, R. L., Wagner, W., Wallny, R., Walter, T., Wan, Z., Wang, M. J., Wang, S. M., Warburton, A., Ward, B., Waschke, S., Waters, D., Watts, T., Weber, M., WesterIII, W. C., Whitehouse, B., Whiteson, D., Wicklund, A. B., Wicklund, E., Williams, H. H., Wilson, P., Winer, B. L., Wittich, P., Wolbers, S., Wolfe, C., Wolter, M., Worcester, M., Worm, S., Wright, T., Wu, X., Würthwein, F., Wyatt, A., Yagil, A., Yamashita, T., Yamamoto, K., Yamaoka, J., Yang, C., Yang, U. K., Yao, W., Yeh, G. P., Yoh, J., Yorita, K., Yoshida, T., Yu, I., Yu, S., Yun, J. C., Zanello, L., Zanetti, A., Zaw, I., Zetti, F., Zhou, J., and Zucchelli, S.
Subjects: High Energy Physics - Experiment
Abstract: We report on a search for pair production of first-generation scalar leptoquarks ($LQ$) in $p \bar{p}$ collisions at $\sqrt{s}$=1.96 TeV using an integrated luminosity of 203 $pb^{-1}$ collected at the Fermilab Tevatron collider by the CDF experiment. We observe no evidence for $LQ$ production in the topologies arising from $LQ \bar{LQ} \to eqeq$ and $LQ \bar{LQ} \to eq \nu q$, and derive 95% C.L. upper limits on the $LQ$ production cross section. %as a function of $\beta$, where $\beta$ is the branching fraction for $LQ \to eq$. The results are combined with those obtained from a separately reported CDF search in the topology arising from $LQ\bar{LQ} \to \nu q \nu q$ and 95% C.L. lower limits on the LQ mass as a function of $\beta = BR(LQ \to eq) $ are derived. The limits are 236, 205 and 145 GeV/c$^2$ for $\beta$ = 1, $\beta$ = 0.5 and $\beta$ = 0.1, respectively., Comment: submitted to PRL
Published: 2005
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5. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

Author: Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, Wechsler, L, Streib, S, Rangaraju, S, Campbell, D, Rocha, M, Gulati, D, Krings, T, Kalman, L, Cayley, A, Williams, J, Wiegner, R, Casaubon, LK, Jaigobin, C, del Campo, JM, Elamin, E, Schaafsma, JD, Agid, R, Farb, R, ter Brugge, K, Sapkoda, BL, Baxter, BW, Barton, K, Knox, A, Porter, A, Sirelkhatim, A, Devlin, T, Dellinger, C, Pitiyanuvath, N, Patterson, J, Nichols, J, Quarfordt, S, Calvert, J, Hawk, H, Fanale, C, Bitner, A, Novak, A, Huddle, D, Bellon, R, Loy, D, Wagner, J, Chang, I, Lampe, E, Spencer, B, Pratt, R, Bartt, R, Shine, S, Dooley, G, Nguyen, T, Whaley, M, McCarthy, K, Teitelbaum, J, Poon, W, Campbell, N, Cortes, M, Lum, C, Shamloul, R, Robert, S, Stotts, G, Shamy, M, Steffenhagen, N, Blacquiere, D, Hogan, M, AlHazzaa, M, Basir, G, Lesiuk, H, Iancu, D, Santos, M, Choe, H, Weisman, DC, Jonczak, K, Blue-Schaller, A, Shah, Q, MacKenzie, L, Klein, B, Kulandaivel, K, Kozak, O, Gzesh, DJ, Harris, LJ, Khoury, JS, Mandzia, J, Pelz, D, Crann, S, Fleming, L, Hesser, K, 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Ajlan, Fahad S, Reddy, Vivek, Dowlatshahi, Dar, Sourour, Nader-Antoine, Oppenheim, Catherine, Mitha, Alim P, Weimar, Christian, van Oostenbrugge, Robert J, Cobo, Erik, Demchuk, Andrew M, Boers, Anna M M, Ford, Gary A, Brown, B Scott, Jovin, Tudor, van Zwam, Wim H, Hill, Michael D, White, Phil, and Bracard, Serge
Published: 2018
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6. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Author: Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, 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Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Campbell, Bruce C V, van Zwam, Wim H, Menon, Bijoy K, Dippel, Diederik W J, Demchuk, Andrew M, Bracard, Serge, Dávalos, Antoni, Majoie, Charles B L M, Ford, Gary A, de la Ossa, Natalia Pérez, Kelly, Michael, Bourcier, Romain, Roos, Yvo B W E M, Bang, Oh Young, Nogueira, Raul G, Devlin, Thomas G, Clarençon, Frédéric, Burns, Paul, Carpenter, Jeffrey, Yavagal, Dileep R, Pereira, Vitor Mendes, Quesada, Helena, Epstein, Jonathan, Rubiera, Marta, Urra, Xabier, Micard, Emilien, Brown, Scott, Guillemin, Francis, van Oostenbrugge, Robert J, Jovin, Tudor G, and Hill, Michael D
Published: 2018
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7. Aggregation of Human Mesenchymal Stromal Cells Eliminates Their Ability to Suppress Human T Cells

Author: Anthony J. Burand, Lin Di, Lauren K. Boland, Devlin T. Boyt, Michael V. Schrodt, Donna A. Santillan, and James A. Ankrum
Subjects: mesenchymal stem cells (MSCs), budesonide, PGE2, synergy, T cell, proliferation, Immunologic diseases. Allergy, RC581-607
Abstract: Mesenchymal stromal cells (MSCs) are administered locally to treat sites of inflammation. Local delivery is known to cause MSCs to aggregate into “spheroids,” which alters gene expression and phenotype. While adherent MSCs are highly efficient in their inhibition of T cells, whether or not this property is altered upon MSC aggregation has not been thoroughly determined. In this study, we discovered that aggregation of MSCs into spheroids causes them to lose their T cell-suppressive abilities. Interestingly, adding budesonide, a topical glucocorticoid steroid, alongside spheroids partially restored MSC suppression of T cell proliferation. Through a series of inhibition and add-back studies, we determined budesonide acts synergistically with spheroid MSC-produced PGE2 to suppress T cell proliferation through the PGE2 receptors EP2 and EP4. These findings highlight critical differences between adherent and spheroid MSC interactions with human immune cells that have significant translational consequences. In addition, we uncovered a mechanism through which spheroid MSC suppression of T cells can be partly restored. By understanding the phenotypic changes that occur upon MSC aggregation and the impact of MSC drug interactions, improved immunosuppressive MSC therapies for localized delivery can be designed.
Published: 2020
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8. Aerobic granular sludge: State of the art, applications, and new perspectives

Author: Corsino, S. F., primary, Devlin, T. R., additional, Oleszkiewicz, J. A., additional, and Torregrossa, M., additional
Published: 2019
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9. Nature vs. Nurture: Defining the Effects of Mesenchymal Stromal Cell Isolation and Culture Conditions on Resiliency to Palmitate Challenge

Author: Lauren K. Boland, Anthony J. Burand, Devlin T. Boyt, Hannah Dobroski, Lin Di, Jesse N. Liszewski, Michael V. Schrodt, Maria K. Frazer, Donna A. Santillan, and James A. Ankrum
Subjects: mesenchymal stromal cells, umbilical cord mesenchymal stromal cells, obesity, palmitate, human platelet lysate, fetal bovine serum, Immunologic diseases. Allergy, RC581-607
Abstract: As MSC products move from early development to clinical translation, culture conditions shift from xeno- to xeno-free systems. However, the impact of isolation and culture-expansion methods on the long-term resiliency of MSCs within challenging transplant environments is not fully understood. Recent work in our lab has shown that palmitate, a saturated fatty acid elevated in the serum of patients with obesity, causes MSCs to convert from an immunosuppressive to an immunostimulatory state at moderate to high physiological levels. This demonstrated that metabolically-diseased environments, like obesity, alter the immunomodulatory efficacy of healthy donor MSCs. In addition, it highlighted the need to test MSC efficacy not only in ideal conditions, but within challenging metabolic environments. To determine how the choice of xeno- vs. xeno-free media during isolation and expansion would affect future immunosuppressive function, umbilical cord explants from seven donors were subdivided and cultured within xeno- (fetal bovine serum, FBS) or xeno-free (human platelet lysate, PLT) medias, creating 14 distinct MSC preparations. After isolation and primary expansion, umbilical cord MSCs (ucMSC) were evaluated according to the ISCT minimal criteria for MSCs. Following baseline characterization, ucMSC were exposed to physiological doses of palmitate and analyzed for metabolic health, apoptotic induction, and immunomodulatory potency in co-cultures with stimulated human peripheral blood mononuclear cells. The paired experimental design (each ucMSC donor grown in two distinct culture environments) allowed us to delineate the contribution of inherent (nature) vs. environmentally-driven (nurture) donor characteristics to the phenotypic response of ucMSC during palmitate exposure. Culturing MSCs in PLT-media led to more consistent growth characteristics during the isolation and expansion for all donors, resulting in faster doubling times and higher cell yields compared to FBS. Upon palmitate challenge, PLT-ucMSCs showed a higher susceptibility to palmitate-induced metabolic disturbance, but less susceptibility to palmitate-induced apoptosis. Most striking however, was that the PLT-ucMSCs resisted the conversion to an immunostimulatory phenotype better than their FBS counterparts. Interestingly, examining MSC suppression of PBMC proliferation at physiologic doses of palmitate magnified the differences between donors, highlighting the utility of evaluating MSC products in stress-based assays that reflect the challenges MSCs may encounter post-transplantation.
Published: 2019
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10. Global impact of COVID-19 on stroke care

Author: Nogueira, R.G. Abdalkader, M. Qureshi, M.M. Frankel, M.R. Mansour, O.Y. Yamagami, H. Qiu, Z. Farhoudi, M. Siegler, J.E. Yaghi, S. Raz, E. Sakai, N. Ohara, N. Piotin, M. Mechtouff, L. Eker, O. Chalumeau, V. Kleinig, T.J. Pop, R. Liu, J. Winters, H.S. Shang, X. Vasquez, A.R. Blasco, J. Arenillas, J.F. Martinez-Galdamez, M. Brehm, A. Psychogios, M.-N. Lylyk, P. Haussen, D.C. Al-Bayati, A.R. Mohammaden, M.H. Fonseca, L. Luís Silva, M. Montalverne, F. Renieri, L. Mangiafico, S. Fischer, U. Gralla, J. Frei, D. Chugh, C. Mehta, B.P. Nagel, S. Mohlenbruch, M. Ortega-Gutierrez, S. Farooqui, M. Hassan, A.E. Taylor, A. Lapergue, B. Consoli, A. Campbell, B.C.V. Sharma, M. Walker, M. Van Horn, N. Fiehler, J. Nguyen, H.T. Nguyen, Q.T. Watanabe, D. Zhang, H. Le, H.V. Nguyen, V.Q. Shah, R. Devlin, T. Khandelwal, P. Linfante, I. Izzath, W. Lavados, P.M. Olavarría, V.V. Sampaio Silva, G. de Carvalho Sousa, A.V. Kirmani, J. Bendszus, M. Amano, T. Yamamoto, R. Doijiri, R. Tokuda, N. Yamada, T. Terasaki, T. Yazawa, Y. Morris, J.G. Griffin, E. Thornton, J. Lavoie, P. Matouk, C. Hill, M.D. Demchuk, A.M. Killer-Oberpfalzer, M. Nahab, F. Altschul, D. Ramos-Pachón, A. Pérez de la Ossa, N. Kikano, R. Boisseau, W. Walker, G. Cordina, S.M. Puri, A. Luisa Kuhn, A. Gandhi, D. Ramakrishnan, P. Novakovic-White, R. Chebl, A. Kargiotis, O. Czap, A. Zha, A. Masoud, H.E. Lopez, C. Ozretic, D. Al-Mufti, F. Zie, W. Duan, Z. Yuan, Z. Huang, W. Hao, Y. Luo, J. Kalousek, V. Bourcier, R. Guile, R. Hetts, S. Al-Jehani, H.M. AlHazzani, A. Sadeghi-Hokmabadi, E. Teleb, M. Payne, J. Lee, J.S. Hong, J.M. Sohn, S.-I. Hwang, Y.-H. Shin, D.H. Roh, H.G. Edgell, R. Khatri, R. Smith, A. Malik, A. Liebeskind, D. Herial, N. Jabbour, P. Magalhaes, P. Ozdemir, A.O. Aykac, O. Uwatoko, T. Dembo, T. Shimizu, H. Sugiura, Y. Miyashita, F. Fukuda, H. Miyake, K. Shimbo, J. Sugimura, Y. Beer-Furlan, A. Joshi, K. Catanese, L. Abud, D.G. Neto, O.G. Mehrpour, M. Al Hashmi, A. Saqqur, M. Mostafa, A. Fifi, J.T. Hussain, S. John, S. Gupta, R. Sivan-Hoffmann, R. Reznik, A. Sani, A.F. Geyik, S. Akıl, E. Churojana, A. Ghoreishi, A. Saadatnia, M. Sharifipour, E. Ma, A. Faulder, K. Wu, T. Leung, L. Malek, A. Voetsch, B. Wakhloo, A. Rivera, R. Barrientos Iman, D.M. Pikula, A. Lioutas, V.-A. Thomalla, G. Birnbaum, L. Machi, P. Bernava, G. McDermott, M. Kleindorfer, D. Wong, K. Patterson, M.S. Fiorot, J.A., Jr. Huded, V. Mack, W. Tenser, M. Eskey, C. Multani, S. Kelly, M. Janardhan, V. Cornett, O. Singh, V. Murayama, Y. Mokin, M. Yang, P. Zhang, X. Yin, C. Han, H. Peng, Y. Chen, W. Crosa, R. Frudit, M.E. Pandian, J.D. Kulkarni, A. Yagita, Y. Takenobu, Y. Matsumaru, Y. Yamada, S. Kono, R. Kanamaru, T. Yamazaki, H. Sakaguchi, M. Todo, K. Yamamoto, N. Sonoda, K. Yoshida, T. Hashimoto, H. Nakahara, I. Cora, E. Volders, D. Ducroux, C. Shoamanesh, A. Ospel, J. Kaliaev, A. Ahmed, S. Rashid, U. Rebello, L.C. Pereira, V.M. Fahed, R. Chen, M. Sheth, S.A. Palaiodimou, L. Tsivgoulis, G. Chandra, R. Koyfman, F. Leung, T. Khosravani, H. Dharmadhikari, S. Frisullo, G. Calabresi, P. Tsiskaridze, A. Lobjanidze, N. Grigoryan, M. Czlonkowska, A. de Sousa, D.A. Demeestere, J. Liang, C. Sangha, N. Lutsep, H.L. Ayo-Martín, Ó. Cruz-Culebras, A. Tran, A.D. Young, C.Y. Cordonnier, C. Caparros, F. De Lecinana, M.A. Fuentes, B. Yavagal, D. Jovin, T. Spelle, L. Moret, J. Khatri, P. Zaidat, O. Raymond, J. Martins, S. Nguyen, T.
Abstract: Background: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. Aims: We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at the height of the pandemic (1 March–31 May 2020) compared with two control three-month periods (immediately preceding and one year prior). Methods: Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating centers. Results: The hospitalization volumes for any stroke, intracranial hemorrhage, and mechanical thrombectomy were 26,699, 4002, and 5191 in the three months immediately before versus 21,576, 3540, and 4533 during the first three pandemic months, representing declines of 19.2% (95%CI, −19.7 to −18.7), 11.5% (95%CI, −12.6 to −10.6), and 12.7% (95%CI, −13.6 to −11.8), respectively. The decreases were noted across centers with high, mid, and low COVID-19 hospitalization burden, and also across high, mid, and low volume stroke/mechanical thrombectomy centers. High-volume COVID-19 centers (−20.5%) had greater declines in mechanical thrombectomy volumes than mid- (−10.1%) and low-volume (−8.7%) centers (p < 0.0001). There was a 1.5% stroke rate across 54,366 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.9% (784/20,250) of all stroke admissions. Conclusion: The COVID-19 pandemic was associated with a global decline in the volume of overall stroke hospitalizations, mechanical thrombectomy procedures, and intracranial hemorrhage admission volumes. Despite geographic variations, these volume reductions were observed regardless of COVID-19 hospitalization burden and pre-pandemic stroke/mechanical thrombectomy volumes. © 2021 World Stroke Organization.
Published: 2021

11. Global impact of COVID-19 on stroke care

Author: Nogueira, RG, Abdalkader, M, Qureshi, MM, Frankel, MR, Mansour, OY, Yamagami, H, Qiu, Z, Farhoudi, M, Siegler, JE, Yaghi, S, Raz, E, Sakai, N, Ohara, N, Piotin, M, Mechtouff, L, Eker, O, Chalumeau, V, Kleinig, TJ, Pop, R, Liu, J, Winters, HS, Shang, X, Rodriguez Vasquez, A, Blasco, J, Arenillas, JF, Martinez-Galdamez, M, Brehm, A, Psychogios, M-N, Lylyk, P, Haussen, DC, Al-Bayati, AR, Mohammaden, MH, Fonseca, L, Luis Silva, M, Montalverne, F, Renieri, L, Mangiafico, S, Fischer, U, Gralla, J, Frei, D, Chugh, C, Mehta, BP, Nagel, S, Mohlenbruch, M, Ortega-Gutierrez, S, Farooqui, M, Hassan, AE, Taylor, A, Lapergue, B, Consoli, A, Campbell, BCV, Sharma, M, Walker, M, Van Horn, N, Fiehler, J, Huy, TN, Nguyen, QT, Watanabe, D, Zhang, H, Le, HV, Nguyen, VQ, Shah, R, Devlin, T, Khandelwal, P, Linfante, I, Izzath, W, Lavados, PM, Olavarria, VV, Silva, GS, de Carvalho Sousa, AV, Kirmani, J, Bendszus, M, Amano, T, Yamamoto, R, Doijiri, R, Tokuda, N, Yamada, T, Terasaki, T, Yazawa, Y, Morris, JG, Griffin, E, Thornton, J, Lavoie, P, Matouk, C, Hill, MD, Demchuk, AM, Killer-Oberpfalzer, M, Nahab, F, Altschul, D, Ramos-Pachon, A, Perez de la Ossa, N, Kikano, R, Boisseau, W, Walker, G, Cordina, SM, Puri, A, Kuhn, AL, Gandhi, D, Ramakrishnan, P, Novakovic-White, R, Chebl, A, Kargiotis, O, Czap, A, Zha, A, Masoud, HE, Lopez, C, Ozretic, D, Al-Mufti, F, Zie, W, Duan, Z, Yuan, Z, Huang, W, Hao, Y, Luo, J, Kalousek, V, Bourcier, R, Guile, R, Hetts, S, Al-Jehani, HM, AlHazzani, A, Sadeghi-Hokmabadi, E, Teleb, M, Payne, J, Lee, JS, Hong, JM, Sohn, S-I, Hwang, Y-H, Shin, DH, Roh, HG, Edgell, R, Khatri, R, Smith, A, Malik, A, Liebeskind, D, Herial, N, Jabbour, P, Magalhaes, P, Ozdemir, AO, Aykac, O, Uwatoko, T, Dembo, T, Shimizu, H, Sugiura, Y, Miyashita, F, Fukuda, H, Miyake, K, Shimbo, J, Sugimura, Y, Beer-Furlan, A, Joshi, K, Catanese, L, Abud, DG, Pontes Neto, O, Mehrpour, M, Al Hashmi, A, Saqqur, M, Mostafa, A, Fifi, JT, Hussain, S, John, S, Gupta, R, Sivan-Hoffmann, R, Reznik, A, Sani, AF, Geyik, S, Akil, ECR, Churojana, A, Ghoreishi, A, Saadatnia, M, Sharifipour, E, Ma, A, Faulder, K, Wu, T, Leung, L, Malek, A, Voetsch, B, Wakhloo, A, Rivera, R, Barrientos Iman, DM, Pikula, A, Lioutas, V-A, Thomalla, G, Birnbaum, L, Machi, P, Bernava, G, McDermott, M, Kleindorfer, D, Wong, K, Patterson, MS, Fiorot, JA, Huded, V, Mack, W, Tenser, M, Eskey, C, Multani, S, Kelly, M, Janardhan, V, Cornett, O, Singh, V, Murayama, Y, Mokin, M, Yang, P, Zhang, X, Yin, C, Han, H, Peng, Y, Chen, W, Crosa, R, Frudit, ME, Pandian, JD, Kulkarni, A, Yagita, Y, Takenobu, Y, Matsumaru, Y, Yamada, S, Kono, R, Kanamaru, T, Yamazaki, H, Sakaguchi, M, Todo, K, Yamamoto, N, Sonoda, K, Yoshida, T, Hashimoto, H, Nakahara, I, Cora, E, Volders, D, Ducroux, C, Shoamanesh, A, Ospel, J, Kaliaev, A, Ahmed, S, Rashid, U, Rebello, LC, Pereira, VM, Fahed, R, Chen, M, Sheth, SA, Palaiodimou, L, Tsivgoulis, G, Chandra, R, Koyfman, F, Leung, T, Khosravani, H, Dharmadhikari, S, Frisullo, G, Calabresi, P, Tsiskaridze, A, Lobjanidze, N, Grigoryan, M, Czlonkowska, A, de Sousa, DA, Demeestere, J, Liang, C, Sangha, N, Lutsep, HL, Ayo-Martin, O, Cruz-Culebras, A, Tran, AD, Young, CY, Cordonnier, C, Caparros, F, Alonso De Lecinana, M, Fuentes, B, Yavagal, D, Jovin, T, Spelle, L, Moret, J, Khatri, P, Zaidat, O, Raymond, J, Martins, S, Thanh, N, Nogueira, RG, Abdalkader, M, Qureshi, MM, Frankel, MR, Mansour, OY, Yamagami, H, Qiu, Z, Farhoudi, M, Siegler, JE, Yaghi, S, Raz, E, Sakai, N, Ohara, N, Piotin, M, Mechtouff, L, Eker, O, Chalumeau, V, Kleinig, TJ, Pop, R, Liu, J, Winters, HS, Shang, X, Rodriguez Vasquez, A, Blasco, J, Arenillas, JF, Martinez-Galdamez, M, Brehm, A, Psychogios, M-N, Lylyk, P, Haussen, DC, Al-Bayati, AR, Mohammaden, MH, Fonseca, L, Luis Silva, M, Montalverne, F, Renieri, L, Mangiafico, S, Fischer, U, Gralla, J, Frei, D, Chugh, C, Mehta, BP, Nagel, S, Mohlenbruch, M, Ortega-Gutierrez, S, Farooqui, M, Hassan, AE, Taylor, A, Lapergue, B, Consoli, A, Campbell, BCV, Sharma, M, Walker, M, Van Horn, N, Fiehler, J, Huy, TN, Nguyen, QT, Watanabe, D, Zhang, H, Le, HV, Nguyen, VQ, Shah, R, Devlin, T, Khandelwal, P, Linfante, I, Izzath, W, Lavados, PM, Olavarria, VV, Silva, GS, de Carvalho Sousa, AV, Kirmani, J, Bendszus, M, Amano, T, Yamamoto, R, Doijiri, R, Tokuda, N, Yamada, T, Terasaki, T, Yazawa, Y, Morris, JG, Griffin, E, Thornton, J, Lavoie, P, Matouk, C, Hill, MD, Demchuk, AM, Killer-Oberpfalzer, M, Nahab, F, Altschul, D, Ramos-Pachon, A, Perez de la Ossa, N, Kikano, R, Boisseau, W, Walker, G, Cordina, SM, Puri, A, Kuhn, AL, Gandhi, D, Ramakrishnan, P, Novakovic-White, R, Chebl, A, Kargiotis, O, Czap, A, Zha, A, Masoud, HE, Lopez, C, Ozretic, D, Al-Mufti, F, Zie, W, Duan, Z, Yuan, Z, Huang, W, Hao, Y, Luo, J, Kalousek, V, Bourcier, R, Guile, R, Hetts, S, Al-Jehani, HM, AlHazzani, A, Sadeghi-Hokmabadi, E, Teleb, M, Payne, J, Lee, JS, Hong, JM, Sohn, S-I, Hwang, Y-H, Shin, DH, Roh, HG, Edgell, R, Khatri, R, Smith, A, Malik, A, Liebeskind, D, Herial, N, Jabbour, P, Magalhaes, P, Ozdemir, AO, Aykac, O, Uwatoko, T, Dembo, T, Shimizu, H, Sugiura, Y, Miyashita, F, Fukuda, H, Miyake, K, Shimbo, J, Sugimura, Y, Beer-Furlan, A, Joshi, K, Catanese, L, Abud, DG, Pontes Neto, O, Mehrpour, M, Al Hashmi, A, Saqqur, M, Mostafa, A, Fifi, JT, Hussain, S, John, S, Gupta, R, Sivan-Hoffmann, R, Reznik, A, Sani, AF, Geyik, S, Akil, ECR, Churojana, A, Ghoreishi, A, Saadatnia, M, Sharifipour, E, Ma, A, Faulder, K, Wu, T, Leung, L, Malek, A, Voetsch, B, Wakhloo, A, Rivera, R, Barrientos Iman, DM, Pikula, A, Lioutas, V-A, Thomalla, G, Birnbaum, L, Machi, P, Bernava, G, McDermott, M, Kleindorfer, D, Wong, K, Patterson, MS, Fiorot, JA, Huded, V, Mack, W, Tenser, M, Eskey, C, Multani, S, Kelly, M, Janardhan, V, Cornett, O, Singh, V, Murayama, Y, Mokin, M, Yang, P, Zhang, X, Yin, C, Han, H, Peng, Y, Chen, W, Crosa, R, Frudit, ME, Pandian, JD, Kulkarni, A, Yagita, Y, Takenobu, Y, Matsumaru, Y, Yamada, S, Kono, R, Kanamaru, T, Yamazaki, H, Sakaguchi, M, Todo, K, Yamamoto, N, Sonoda, K, Yoshida, T, Hashimoto, H, Nakahara, I, Cora, E, Volders, D, Ducroux, C, Shoamanesh, A, Ospel, J, Kaliaev, A, Ahmed, S, Rashid, U, Rebello, LC, Pereira, VM, Fahed, R, Chen, M, Sheth, SA, Palaiodimou, L, Tsivgoulis, G, Chandra, R, Koyfman, F, Leung, T, Khosravani, H, Dharmadhikari, S, Frisullo, G, Calabresi, P, Tsiskaridze, A, Lobjanidze, N, Grigoryan, M, Czlonkowska, A, de Sousa, DA, Demeestere, J, Liang, C, Sangha, N, Lutsep, HL, Ayo-Martin, O, Cruz-Culebras, A, Tran, AD, Young, CY, Cordonnier, C, Caparros, F, Alonso De Lecinana, M, Fuentes, B, Yavagal, D, Jovin, T, Spelle, L, Moret, J, Khatri, P, Zaidat, O, Raymond, J, Martins, S, and Thanh, N
Abstract: BACKGROUND: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. AIMS: We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at the height of the pandemic (1 March-31 May 2020) compared with two control three-month periods (immediately preceding and one year prior). METHODS: Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating centers. RESULTS: The hospitalization volumes for any stroke, intracranial hemorrhage, and mechanical thrombectomy were 26,699, 4002, and 5191 in the three months immediately before versus 21,576, 3540, and 4533 during the first three pandemic months, representing declines of 19.2% (95%CI, -19.7 to -18.7), 11.5% (95%CI, -12.6 to -10.6), and 12.7% (95%CI, -13.6 to -11.8), respectively. The decreases were noted across centers with high, mid, and low COVID-19 hospitalization burden, and also across high, mid, and low volume stroke/mechanical thrombectomy centers. High-volume COVID-19 centers (-20.5%) had greater declines in mechanical thrombectomy volumes than mid- (-10.1%) and low-volume (-8.7%) centers (p < 0.0001). There was a 1.5% stroke rate across 54,366 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.9% (784/20,250) of all stroke admissions. CONCLUSION: The COVID-19 pandemic was associated with a global decline in the volume of overall stroke hospitalizations, mechanical thrombectomy procedures, and intracranial hemorrhage admission volumes. Despite geographic variations, these volume reductions were observed regardless of COVID-19 hospitalization burden and pre-pandemic stroke/mechanical thrombectomy volumes.
Published: 2021

12. The Simons Observatory: metamaterial microwave absorber and its cryogenic applications

Author: Xu, Z, Chesmore, G, Adachi, S, Ali, A, Bazarko, A, Coppi, G, Devlin, M, Devlin, T, Dicker, S, Gallardo, P, Golec, J, Gudmundsson, J, Harrington, K, Hattori, M, Kofman, A, Kiuchi, K, Kusaka, A, Limon, M, Matsuda, F, Mcmahon, J, Nati, F, Niemack, M, Suzuki, A, Teply, G, Thornton, R, Wollack, E, Zannoni, M, Zhu, N, Xu, Zhilei, Chesmore, Grace E., Adachi, Shunsuke, Ali, Aamir M., Bazarko, Andrew, Coppi, Gabriele, Devlin, Mark, Devlin, Tom, Dicker, Simon R., Gallardo, Patricio A., Golec, Joseph E., Gudmundsson, Jon E., Harrington, Kathleen, Hattori, Makoto, Kofman, Anna, Kiuchi, Kenji, Kusaka, Akito, Limon, Michele, Matsuda, Frederick, McMahon, Jeff, Nati, Federico, Niemack, Michael D., Suzuki, Aritoki, Teply, Grant P., Thornton, Robert J., Wollack, Edward J., Zannoni, Mario, Zhu, Ningfeng, Xu, Z, Chesmore, G, Adachi, S, Ali, A, Bazarko, A, Coppi, G, Devlin, M, Devlin, T, Dicker, S, Gallardo, P, Golec, J, Gudmundsson, J, Harrington, K, Hattori, M, Kofman, A, Kiuchi, K, Kusaka, A, Limon, M, Matsuda, F, Mcmahon, J, Nati, F, Niemack, M, Suzuki, A, Teply, G, Thornton, R, Wollack, E, Zannoni, M, Zhu, N, Xu, Zhilei, Chesmore, Grace E., Adachi, Shunsuke, Ali, Aamir M., Bazarko, Andrew, Coppi, Gabriele, Devlin, Mark, Devlin, Tom, Dicker, Simon R., Gallardo, Patricio A., Golec, Joseph E., Gudmundsson, Jon E., Harrington, Kathleen, Hattori, Makoto, Kofman, Anna, Kiuchi, Kenji, Kusaka, Akito, Limon, Michele, Matsuda, Frederick, McMahon, Jeff, Nati, Federico, Niemack, Michael D., Suzuki, Aritoki, Teply, Grant P., Thornton, Robert J., Wollack, Edward J., Zannoni, Mario, and Zhu, Ningfeng
Abstract: Controlling stray light at millimeter wavelengths requires special optical design and selection of absorptive materials that should be compatible with cryogenic operating environments. While a wide selection of absorptive materials exists, these typically exhibit high indices of refraction and reflect/scatter a significant fraction of light before absorption. For many lower index materials such as commercial microwave absorbers, their applications in cryogenic environments are challenging. In this paper, we present a new tool to control stray light: metamaterial microwave absorber tiles. These tiles comprise an outer metamaterial layer that approximates a lossy gradient index anti-reflection coating. They are fabricated via injection molding commercially available carbon-loaded polyurethane (25% by mass). The injection molding technology enables mass production at low cost. The design of these tiles is presented, along with thermal tests to 1 K. Room temperature optical measurements verify their control of reflectance to less than 1% up to 65∘ angles of incidence, and control of wide angle scattering below 0.01%. The dielectric properties of the bulk carbon-loaded material used in the tiles is also measured at different temperatures, confirming that the material maintains similar dielectric properties down to 3 K.
Published: 2021

13. The merci retrieval system for acute stroke: The southeast regional stroke center experience

Author: Devlin, T. G., Baxter, B. W., Feintuch, T. A., and Desbiens, N. A.
Published: 2007
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14. P02.39. Leveraging grant awards to enhance the research infrastructure at a CAM institution

Author: Pohlman K, Carber L, Vining R, Devlin T, Rice R, Salsbury S, Corber L, Hondras M, Long C, and Goertz C
Subjects: Other systems of medicine, RZ201-999
Published: 2012
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15. Free Communication Abstracts

Author: Kaul, Prashan T., Passafiume, Jasonm, O’Hara, Bruce F., Vetrivelan, Ramalingam, Mallick, Hruda Nanda, Kumar, Velayadhan Mohan, Zhan, G.-X., Serrano, F., Fenik, P., Hsu, R., Kong, L., Pratico, D., Klann, E., Veasey, S. C., Mahapatra, Ambika Prasad K., Kumar, Velayudhan Mohan, Kuwaki, Tomoyuki, Den, Ben-Shiang, Nakamura, Akira, Zhang, Wei, Yanagisawa, Masashi, Fukuda, Yasuichiro, Andersen, Monica L., Tufik, Sergio, Antunes, Isabela B., Perry, Juliana C., Tufik, S., Andersen, M. L., Batista, M. C., Calzavara, M. B., Costa, J. L., Frussa-Filho, Désarnaud, F., Murillo-Rodriguez, E., Gerashchenko, D., Shiromani, S., Lin, L., Nishino, S., Mignot, E., Shiromani, P. J., Blanco-Centurion, Carlos, Shiromani, Priyattam J., Ling, L., Xu, M., Blanco-Centurion, C., Mikko, Härmä, Mikael, Sallinen, Jain, Shamini, Mills, Paul J., Liu, Lianqi, Ancoli-Israel, Sonia, Haimov, I., Breznitz, N., Shiloh, S., Silvestri, R., Aricò, I., Mento, G., Gagliano, A., Calarese, T., di Perri, C., Epstein, R., Tzischinsky, O., Naveh, R., Herer, P., Pillar, G., Adami, H., Lavie, P., Marks, Gerald A., Sachs, Oren, Birabil, Christian C., Roky, Rachida, Benaji, Brahim, Benchekroun, Majda Taoudi, Chapotot, Florian, Buguet, Alain, Rao, Uma, Poland, Russell E., Puvanendran, K., Mishima, Yumiko, Mishima, Kazuo, Hozumi, Satoshi, Shimizu, Tetsuo, Hishikawa, Yasuo, Toledo, Juan C., Koyama, Yoshimasa, Kayama, Yukihiko, Iwasaki, Hiroshi, Kawauchi, Akihiro, Miki, Tsuneharo, Yaegashi, Hironobu, Takahashi, Yasuro, Inoue, Yuichi, Ishiura, Daiki, Yamamoto, Keisuke, Nakao, Mitsuyuki, Katayama, Norihito, Yamamoto, Mitsuaki, Matsumoto, Yasuhiro, Satoh, Kohtoku, Tozawa, Takuma, Lack, Leon, Bramwell, Toby, Wright, Helen, Gradisar, Michael, Storrs, P., Mckenna, F., Hume, K., Loshkarev, Alexander A., Rodionova, Elena I., Levichkina, Ekaterina V., Pigarev, Ivan N., de Koninck, Joseph, Maganti, Rama, Biswas, Amit, Kiyashchenko, Lyudmila I., Mileykovskiy, Boris Y., Siegel, Jerome M., Methippara, Melvi, Kumar, Sunil, Alam, Noor, Szymusiak, Ronald, Mcginty, Dennis, Richardson, Heidi L., Parslow, Peter M., Walker, Adrian M., Harding, Richard, Horne, Rosemary S. C., Tzchishinsky, O., Shochat, T., Nictren, A., Portnoy, T., Peled, R., Bootzin, Richard, Aparicio, S., Garau, C., Rial, R. V., Nicolau, M. C., Rivero, M., Esteban, S., Barriga, M. C., Kuenzel, H. E., Steiger, A., Held, K., Antonijevic, I. A., Frieboes, R. M., Murck, H., Mairesse, Olivier, de Valck, Elke, Theuns, Peter, Cluydts, Raymond, Gvilia, I., Turner, A., Mcginty, D., Szymusiak, R., Lyamin, O. I., Mukhametov, L. M., Kosenko, P. O., Vyssotski, A. L., Lapierre, J. L., Pokidchenko, T. M., Lipp, H. P., Hsieh, Kc, Nguyen, D., Lai, Y. Y., Ramanathan, Lalini, Bashir, Muhammad-Tariq, Guzman-Marin, Ruben, Xu, Feng, Chew, Keng-Tee, Cassaglia, P., Griffiths, R., Walker, A. M., Grant, D. A., Wild, G. Zoccoli, Matsuura, Noriko, Adachi, Naomi, Kaji, Megumi, Aritomi, Ryoji, Basishvili, T., Gogichadze, M., Rukhadze, I., Emukhvari, N., Fujita, Etsunori, Ogura, Yumi, Ochiai, Naoki, Murata, Kohji, Kamei, Tsutomu, Ueno, Yoshiyuki, Kaneko, Shigehiko, Voss, U., Tuin, I., Kessler, K. R., Morales, B., Ziemann, U., Steinmetz, H., Auburger, G., Mishra, J. P. N., Pedemonte, Marisa, Bentancor, Claudia, Velluti, Ricardo A., Zoccoli, Giovanna, Grant, Daniel A., Wild, Jennene, de Gennaro, Luigi, Curcio, Giuseppe, Fratello, Fabiana, Marzano, Cristina, Moroni, Fabio, Pellicciari, Maria Concetta, Ferrara, Michele, Sforza, Emilia, Pal, Dinesh, Mallick, Birendra Nath, Hornung, Orla P., Regen, Francesca, Danker-Hopfe, Heidi, Dorn, Hans, Schredl, Michael, Heuser, Isabella, Rai, Seema, Alam, Md Noor, Aschbacher, Kirstin, Dimsdale, Joel E., Calleran, Susan, Ziegler, Michael G., Patterson, Thomas L., Grant, Igor, Kang, J.-S., Youngstedt, S. D., Kline, C. E., Zielinski, M., Lee, A., Devlin, T. M., Kripke, D. F., Regen, F., Dorn, H., Danker-Hopfe, H., Bassi, Alejandro, Vivaldi, Ennio A., Ocampo-Garcés, Adrian, Galland, Barbara, Tan, Evan, Taylor, Barry, Goulden, Marie, Peled, Nir, Shitrit, David, Kramer, Mordechai R., Dunleavy, Mark, Lane, Donncha, O’Halloran, Ken, Bradford, Aidan, Sverteczki, Melinda, Sándor, Lázár Alpár, Linda, Havrán, TamÁs, Kis, Péter, Rigó, Szilvia, Csóka, Robert, Bódizs, Mccarley, Robert W., Basheer, Radhika, Strecker, Robert E., Farooqui, Ausaf A., Gulia, Kamalesh K., Balakrishnan, D., Thirunavukkarasu, S., Edwin, R., Virudhagirinathan, B. S., Kumar, Deependra, and Srividya, Rajagopalan
Published: 2005
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16. 51. Clinical Presentation and Quality of Life Burden Associated With Hyperhidrosis in Children and Adolescents

Author: Rice, Z.P., primary, Pieretti, L.J., additional, Wheeler, A., additional, Payne, J., additional, Gillard, K.K., additional, Devlin, T., additional, Sidbury, R., additional, and Hebert, A.A., additional
Published: 2021
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17. Dose and duration of interferon γ pre-licensing interact with donor characteristics to influence the expression and function of indoleamine-2,3-dioxygenase in mesenchymal stromal cells

Author: Boyt, Devlin T., primary, Boland, Lauren K., additional, Burand, Anthony J., additional, Brown, Alex J., additional, and Ankrum, James A., additional
Published: 2020
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18. Aggregation of Human Mesenchymal Stromal Cells Eliminates Their Ability to Suppress Human T Cells

Author: Burand, Anthony J., primary, Di, Lin, additional, Boland, Lauren K., additional, Boyt, Devlin T., additional, Schrodt, Michael V., additional, Santillan, Donna A., additional, and Ankrum, James A., additional
Published: 2020
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19. Effect of extra- and intra-mitochondrial calcium on citrulline synthesis

Author: Saavedra-Molina, A. and Devlin, T. M.
Published: 1997
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20. Dose and duration of IFNγ pre-licensing interact with donor characteristics to influence the expression and function of IDO in MSCs

Author: Devlin T. Boyt, James A. Ankrum, Anthony J. Burand, Lauren K. Boland, and Alexander J Brown
Subjects: 0303 health sciences, Donor selection, business.industry, Mesenchymal stem cell, Peripheral blood mononuclear cell, Cell therapy, 03 medical and health sciences, 0302 clinical medicine, Immune system, Mediator, In vivo, 030220 oncology & carcinogenesis, Cancer research, medicine, Interferon gamma, business, 030304 developmental biology, medicine.drug
Abstract: Human mesenchymal stromal cells (MSCs) are a leading cell therapy candidate for the treatment of immune and inflammatory diseases due to their potent regulation of immune cells. MSC expression of indoleamine-2,3-dioxygenase (IDO) upon interferon gamma exposure has been proposed as both a sentinel marker and key mediator of MSC immunomodulatory potency. Rather than wait for in vivo exposure to cytokines, MSCs can be pre-licensed during manufacturing to enhance IDO expression. In this study, we systematically examine the relative role the dose of interferon gamma, the duration of pre-licensing, and the donor of origin plays in dictating MSC production of functional IDO. We find that across three human MSC donors, MSCs increase their expression of IDO in response to both increased dose of interferon gamma and duration of pre-licensing. However, with extended pre-licensing, the expression of IDO no longer predicts MSCs ability to suppress activated peripheral blood mononuclear cells. In addition, pre-licensing dose and duration are revealed to be minor modifiers of MSCs inherent potency, and thus cannot be manipulated to boost poor donors to the levels of high-performing donors. Thus, the dose and duration of pre-licensing should be tailored to optimize performance of specific donors and an emphasis on donor selection is needed to realize significant benefits of pre-licensing.
Published: 2019
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21. Intramitochondrial localization of alanine aminotransferase in rat-liver mitochondria: comparison with glutaminase and aspartate aminotransferase

Author: Masola, B. and Devlin, T. M.
Published: 1995
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22. The left parietal and premotor cortices: motor attention and selection

Author: Rushworth, S. M.F., Johansen-Berg, H, Göbel, M. S., and Devlin, T. J.
Published: 2003
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23. Unstable social structure associated with a population crash in the Tasmanian native hen, Tribonyx mortierii

Author: Goldizen, A.W., Goldizen, A.R., and Devlin, T.
Subjects: Tasmania -- Natural history, Poultry -- Behavior, Animal populations -- Analysis, Zoology and wildlife conservation
Abstract: A pair of color-banded native hens, one near Geeveston in southern Tasmania, which underwent a disastrous decrease in numbers between Feb and Dec 1989, and another at Darlington on Maria Island, off Tasmania's east west, which maintained a stable population density between 1989 and Feb 1992, are compared. The differences in the social structure of these two populations has led to the population reduction at Geeveston. The Tasmanian native hen, Tribonyx mortierii, Rallidae, a flightless bird, generally resides in small, stable groups in regions with open pasture water and thick vegetation.
Published: 1993

24. Dose and duration of interferon γ pre-licensing interact with donor characteristics to influence the expression and function of indoleamine-2,3-dioxygenase in mesenchymal stromal cells

Author: Lauren K. Boland, Anthony J. Burand, Alexander J Brown, James A. Ankrum, and Devlin T. Boyt
Subjects: Biomedical Engineering, Biophysics, Bioengineering, Biochemistry, Peripheral blood mononuclear cell, Immunomodulation, Biomaterials, Cell therapy, Interferon-gamma, Mediator, Immune system, In vivo, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Medicine, Indoleamine 2,3-dioxygenase, Life Sciences–Engineering interface, Cells, Cultured, Cell Proliferation, Donor selection, business.industry, Mesenchymal stem cell, Mesenchymal Stem Cells, Leukocytes, Mononuclear, Cancer research, business, Biotechnology
Abstract: Human mesenchymal stromal cells (MSCs) are a leading cell therapy candidate for the treatment of immune and inflammatory diseases due to their potent regulation of immune cells. MSC expression of indoleamine-2,3-dioxygenase (IDO) upon interferon γ (IFNγ) exposure has been proposed as both a sentinel marker and key mediator of MSC immunomodulatory potency. Rather than wait for in vivo exposure to cytokines, MSCs can be pre-licensed during manufacturing to enhance IDO expression. In this study, we systematically examine the relative role that the dose of IFNγ, the duration of pre-licensing and the donor of origin play in dictating MSC production of functional IDO. We find that across three human MSC donors, MSCs increase their expression of IDO in response to both increased dose of IFNγ and duration of pre-licensing. However, with extended pre-licensing, the expression of IDO no longer predicts MSCs ability to suppress activated peripheral blood mononuclear cells. In addition, pre-licensing dose and duration are revealed to be minor modifiers of MSCs inherent potency, and thus cannot be manipulated to boost poor donors to the levels of high-performing donors. Thus, the dose and duration of pre-licensing should be tailored to optimize performance of specific donors and an emphasis on donor selection is needed to realize significant benefits of pre-licensing.
Published: 2020

25. Aerobic granular sludge: State of the art, applications, and new perspectives

Author: Corsino S. F., Devlin T. R., Oleszkiewicz J. A., Torregrossa M., Mannina G., Ekama G., Odegaard H., Olsson G., and Corsino S.F., Devlin T.R., Oleszkiewicz J. A., Torregrossa M.
Subjects: Settore ICAR/03 - Ingegneria Sanitaria-Ambientale, Aerobic granular sludge, continuous flow reactor, industrial wastewater, municipal wastewater, sequencing batch reactor
Abstract: The aerobic granular sludge (AGS) process has attracted significant interest over the last decade and is one of the most promising wastewater treatment technologies. AGS offers several advantages over conventional activated sludge (CAS) including excellent settling, and higher volumetric loading capacity. Because of porosity, concentration gradients develop and stratified aerobic, anoxic, and anaerobic layers develop throughout granule depth. This is the reason for simultaneous nutrient removal in a single tank. Aerobic granulation is influenced by many parameters including wastewater characteristics and operating conditions. Among these, the anaerobic upflow feeding strategy and a properly balanced feast/famine regime have most significantly influenced granule stability and nutrient removal efficiency. Hydraulic shear forces can improve the physical characteristics of the granules, whereas selective wasting also allows undesirable biomass with low density to be washed out. Implementation of AGS in full-scale requires some important retrofitting, including adequate grit and particulate organics removal from the wastewater. Furthermore, aerobic granular sludge cycles should be designed with flexibility to address variable influent loads. Considerations include equalization and flow balancing, dissolved oxygen control strategies, multiple draw points for selective wasting and swing-capabilities. Several studies and full-scale implementations have demonstrated that AGS is suited for the treatment of a wide variety of industrial wastewaters, as well as municipal wastewater. Full-scale implementations of AGS treating municipal wastewater have improved process stability, attained more stringent effluent quality (i.e., total nitrogen (TN)
Published: 2018

26. Anaerobic moving bed biofilm reactor followed by aerobic granular sludge for brewery wastewater treatment

Author: di Biase A., Corsino S. F., Devlin T. R., Torregrossa M., Munz G., Oleszkiewicz J. A., di Biase A., Corsino S.F., Devlin T.R., Torregrossa M., Munz G., and Oleszkiewicz J.A.
Subjects: Anaerobic moving bed biofilm reactor, Settore ICAR/03 - Ingegneria Sanitaria-Ambientale, Aerobic granular sludge
Abstract: Small and medium breweries discharging to municipal sewers without treatment generate significant loads with typical concentrations reported by Valta et al. (2014) as 2-6 g COD L-1, 25-80 mg TN L-1, 10-50 mg TP L-1, with pH between 4.5 and 12. Treatment of the high-strength wastewater requires specialized low footprint processes, such as aerobic granular sludge (AGS), capable of high-rate degradation, as well as simultaneous nitrogen and phosphorous removal (Wang et al., 2007). The objective of this study was to evaluate the start-up period of AGS receiving brewery wastewater after initial anaerobic pre-treatment.
Published: 2018

27. Nature vs. Nurture: Defining the Effects of Mesenchymal Stromal Cell Isolation and Culture Conditions on Resiliency to Palmitate Challenge

Author: Boland, Lauren K., primary, Burand, Anthony J., additional, Boyt, Devlin T., additional, Dobroski, Hannah, additional, Di, Lin, additional, Liszewski, Jesse N., additional, Schrodt, Michael V., additional, Frazer, Maria K., additional, Santillan, Donna A., additional, and Ankrum, James A., additional
Published: 2019
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28. Alveolar Regulatory T Cell Kinetics in Patients with Acute Respiratory Distress Syndrome

Author: Norton, D., primary, McCravy, M., additional, Tune, M.K., additional, Devlin, T., additional, Drummond, M.B., additional, Doerschuk, C.M., additional, and Mock, J.R., additional
Published: 2019
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29. Change in Transpulmonary Pressure with Prone Positioning in Acute Respiratory Distress Syndrome: A Case Report

Author: Norton, D., primary, Kannappan, A., additional, Devlin, T., additional, and Bice, T., additional
Published: 2019
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30. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Author: Campbell, Bruce C V, primary, Majoie, Charles B L M, additional, Albers, Gregory W, additional, Menon, Bijoy K, additional, Yassi, Nawaf, additional, Sharma, Gagan, additional, van Zwam, Wim H, additional, van Oostenbrugge, Robert J, additional, Demchuk, Andrew M, additional, Guillemin, Francis, additional, White, Philip, additional, Dávalos, Antoni, additional, van der Lugt, Aad, additional, Butcher, Kenneth S, additional, Cherifi, Aboubaker, additional, Marquering, Henk A, additional, Cloud, Geoffrey, additional, Macho Fernández, Juan M, additional, Madigan, Jeremy, additional, Oppenheim, Catherine, additional, Donnan, Geoffrey A, additional, Roos, Yvo B W E M, additional, Shankar, Jai, additional, Lingsma, Hester, additional, Bonafé, Alain, additional, Raoult, Hélène, additional, Hernández-Pérez, María, additional, Bharatha, Aditya, additional, Jahan, Reza, additional, Jansen, Olav, additional, Richard, Sébastien, additional, Levy, Elad I, additional, Berkhemer, Olvert A, additional, Soudant, Marc, additional, Aja, Lucia, additional, Davis, Stephen M, additional, Krings, Timo, additional, Tisserand, Marie, additional, San Román, Luis, additional, Tomasello, Alejandro, additional, Beumer, Debbie, additional, Brown, Scott, additional, Liebeskind, David S, additional, Bracard, Serge, additional, Muir, Keith W, additional, Dippel, Diederik W J, additional, Goyal, Mayank, additional, Saver, Jeffrey L, additional, Jovin, Tudor G, additional, Hill, Michael D, additional, Mitchell, Peter J, additional, Fransen, Puck SS, additional, van den Berg, Lucie A, additional, Lingsma, Hester F, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, additional, Williams, J, additional, Wiegner, R, additional, Casaubon, LK, additional, Jaigobin, C, additional, del Campo, JM, additional, Elamin, E, additional, Schaafsma, JD, additional, Agid, R, additional, Farb, R, additional, ter Brugge, K, additional, Sapkoda, BL, additional, Baxter, BW, additional, Barton, K, additional, Knox, A, additional, Porter, A, additional, Sirelkhatim, A, additional, Devlin, T, additional, Dellinger, C, additional, Pitiyanuvath, N, additional, Patterson, J, additional, Nichols, J, additional, Quarfordt, S, additional, Calvert, J, additional, Hawk, H, additional, Fanale, C, additional, Bitner, A, additional, Novak, A, additional, Huddle, D, additional, Bellon, R, additional, Loy, D, additional, Wagner, J, additional, Chang, I, additional, Lampe, E, additional, Spencer, B, additional, Pratt, R, additional, Bartt, R, additional, Shine, S, additional, Dooley, G, additional, Nguyen, T, additional, Whaley, M, additional, McCarthy, K, additional, Teitelbaum, J, additional, Poon, W, additional, Campbell, N, additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez- Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, P, additional, Golob, D, additional, 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additional, Lees, Kennedy R, additional, Arenillas, J, additional, Roberts, R, additional, Al-Ajlan, F, additional, Zimmel, L, additional, Patel, S, additional, Martí-Fàbregas, J, additional, Salvat-Plana, M, additional, Bracard, S, additional, Ducrocq, Xavier, additional, Anxionnat, René, additional, Baillot, Pierre-Alexandre, additional, Barbier, Charlotte, additional, Derelle, Anne-Laure, additional, Lacour, Jean-Christophe, additional, Samson, Yves, additional, Sourour, Nader, additional, Baronnet-Chauvet, Flore, additional, Clarencon, Frédéric, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Di Maria, Federico, additional, Le Bouc, Raphael, additional, Leger, Anne, additional, Mutlu, Gurkan, additional, Rosso, Charlotte, additional, Szatmary, Zoltan, additional, Yger, Marion, additional, Zavanone, Chiara, additional, Bakchine, Serge, additional, Pierot, Laurent, additional, Caucheteux, Nathalie, additional, Estrade, Laurent, additional, Kadziolka, Krzysztof, additional, Leautaud, Alexandre, additional, Renkes, Céline, additional, Serre, Isabelle, additional, Desal, Hubert, additional, Guillon, Benoît, additional, Boutoleau-Bretonniere, Claire, additional, Daumas-Duport, Benjamin, additional, De Gaalon, Solène, additional, Derkinderen, Pascal, additional, Evain, Sarah, additional, Herisson, Fanny, additional, Laplaud, David-Axel, additional, Lebouvier, Thibaud, additional, Lintia-Gaultier, Alina, additional, Pouclet-Courtemanche, Hélène, additional, Rouaud, Tiphaine, additional, Rouaud Jaffrenou, Violaine, additional, Schunck, Aurélia, additional, Sevin-Allouet, Mathieu, additional, Toulgoat, Frederique, additional, Wiertlewski, Sandrine, additional, Gauvrit, Jean-Yves, additional, Ronziere, Thomas, additional, Cahagne, Vincent, additional, Ferre, Jean-Christophe, additional, Pinel, Jean-François, additional, Mas, Jean-Louis, additional, Meder, Jean-François, additional, Al Najjar-Carpentier, Amen-Adam, additional, Birchenall, Julia, additional, Bodiguel, Eric, additional, Calvet, David, additional, Domigo, Valérie, additional, Godon-Hardy, Sylvie, additional, Guiraud, Vincent, additional, Lamy, Catherine, additional, Majhadi, Loubna, additional, Morin, Ludovic, additional, Naggara, Olivier, additional, Trystram, Denis, additional, Turc, Guillaume, additional, Berge, Jérôme, additional, Sibon, Igor, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Rouanet, François, additional, Debruxelles, Sabrina, additional, Kazadi, Annabelle, additional, Renou, Pauline, additional, Fleury, Olivier, additional, Pasco-Papon, Anne, additional, Dubas, Frédéric, additional, Caroff, Jildaz, additional, Godard Ducceschi, Sophie, additional, Hamon, Marie-Aurélie, additional, Lecluse, Alderic, additional, Marc, Guillaume, additional, Giroud, Maurice, additional, Ricolfi, Frédéric, additional, Bejot, Yannick, additional, Chavent, Adrien, additional, Gentil, Arnaud, additional, Kazemi, Apolline, additional, Osseby, Guy-Victor, additional, Voguet, Charlotte, additional, Mahagne, Marie-Hélène, additional, Sedat, Jacques, additional, Chau, Yves, additional, Suissa, Laurent, additional, Lachaud, Sylvain, additional, Houdart, Emmanuel, additional, Stapf, Christian, additional, Buffon Porcher, Frédérique, additional, Chabriat, Hugues, additional, Guedin, Pierre, additional, Herve, Dominique, additional, Jouvent, Eric, additional, Mawet, Jérôme, additional, Saint-Maurice, Jean-Pierre, additional, Schneble, Hans-Martin, additional, Nighoghossian, Norbert, additional, Berhoune, Nadia-Nawel, additional, Bouhour, Françoise, additional, Cho, Tae-Hee, additional, Derex, Laurent, additional, Felix, Sandra, additional, Gervais-Bernard, Hélène, additional, Gory, Benjamin, additional, Manera, Luis, additional, Mechtouff, Laura, additional, Ritzenthaler, Thomas, additional, Riva, Roberto, additional, Salaris Silvio, Fabrizio, additional, Tilikete, Caroline, additional, Blanc, Raphael, additional, Obadia, 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Charlin, Cyril, additional, Darcel, Françoise, additional, Gauthier-Lasalarie, Pascale, additional, Jeremenko, Marcia, additional, Mouton, Servane, additional, Zerlauth, Jean-Baptiste, additional, Lamy, Chantal, additional, Hervé, Deramond, additional, Hassan, Hosseini, additional, Gaston, André, additional, Barral, Francis-Guy, additional, Garnier, Pierre, additional, Beaujeux, Rémy, additional, Wolff, Valérie, additional, Herbreteau, Denis, additional, Debiais, Séverine, additional, Murray, Alicia, additional, Ford, Gary, additional, Clifton, Andy, additional, Freeman, Janet, additional, Ford, Ian, additional, Markus, Hugh, additional, Wardlaw, Joanna, additional, Molyneux, Andy, additional, Robinson, Thompson, additional, Lewis, Steff, additional, Norrie, John, additional, Robertson, Fergus, additional, Perry, Richard, additional, Dixit, Anand, additional, Clifton, Andrew, additional, Roffe, Christine, additional, Nayak, Sanjeev, additional, Lobotesis, Kyriakos, additional, Smith, Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional
Published: 2019
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31. Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke

Author: Saver, Jeffrey L, Goyal, Mayank, Bonafe, Alain, Diener, Hans Christoph, Levy, Elad I, Pereira, Vitor M, Albers, Gregory W, Cognard, Christophe, Cohen, David J, Hacke, Werner, Jansen, Olav, Jovin, Tudor G, Mattle, Heinrich P, Nogueira, Raul G, Siddiqui, Adnan H, Yavagal, Dileep R, Baxter, Blaise W, Devlin, Thomas G, Lopes, Demetrius K, Reddy, Vivek K, du Mesnil de Rochemont, Richard, Singer, Oliver C, Jahan, Reza, Devlin, T, Baxter, B, Hawk, H, Sapkota, B, Quarfordt, S, Sirelkhatim, A, Dellinger, C, Barton, K, Reddy, V K, Jovin, T G, Ducruet, A, Jadhav, A, Horev, A, Giurgiutiu, D-V, Totoraitis, V, Hammer, M, Jankowitz, B, Wechsler, L, Rocha, M, Gulati, D, Campbell, D, Star, M, Baxendell, L, Oakley, J, Siddiqui, A H, Hopkins, L N, Levy, E, Snyder, K, Sawyer, R, Hall, S, Bonafé, A, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, de Champfleur, N Menjot, Leboucq, N, Gascou, G, Moynier, M, du Mesnil de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, S-J, Lescher, S, Braun, H, Nogueira, R G, Dehkharghani, S, Belagaje, S R, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, D K, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, J S, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, Marc, Göricke, Sophia Luise, Ringlestein, A, Wanke, Isabel, Mönninghoff, Christoph, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, W J, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, Hussain, M S, Russman, A, Hui, F, Wisco, D, Uchino, K, Khawaja, Z, Katzan, I, Toth, G, Cheng-Ching, E, Bain, M, Man, S, Farrag, A, George, P, John, S, Shankar, L, Drofa, A, Dahlgren, R, Bauer, A, Itreat, A, Taqui, A, Cerejo, R, Richmond, A, Ringleb, P, Bendszus, M, Möhlenbruch, M, Reiff, T, Amiri, H, Purrucker, J, Herweh, C, Pham, M, Menn, O, Ludwig, I, Acosta, I, Villar, C, Morgan, W, Sombutmai, C, Hellinger, F, Allen, E, Bellew, M, Gandhi, R, Bonwit, E, Aly, J, Ecker, R D, Seder, D, Morris, J, Skaletsky, M, Belden, J, Baker, C, Connolly, L S, Papanagiotou, P, Roth, C, Kastrup, A, Politi, M, Brunner, F, Alexandrou, M, Merdivan, H, Ramsey, C, Given, C, Renfrow, S, Deshmukh, V, Sasadeusz, K, Vincent, F, Thiesing, J T, Putnam, J, Bhatt, A, Kansara, A, Caceves, D, Lowenkopf, T, Yanase, L, Zurasky, J, Dancer, S, Freeman, B, Scheibe-Mirek, T, Robison, J, Roll, J, Clark, D, Rodriguez, M, Fitzsimmons, B-F M, Zaidat, O, Lynch, J R, Lazzaro, M, Larson, T, Padmore, L, Das, E, Farrow-Schmidt, A, Hassan, A, Tekle, W, Cate, C, Jansen, O, Cnyrim, C, Wodarg, F, Wiese, C, Binder, A, Riedel, C, Rohr, A, Lang, N, Laufs, H, Krieter, S, Remonda, L, Diepers, M, Añon, J, Nedeltchev, K, Kahles, T, Biethahn, S, Lindner, M, Chang, V, Gächter, C, Esperon, C, Guglielmetti, M, Lara, J F Arenillas, Galdámez, M Martínez, Sanz, A I Calleja, Garcia, E Cortijo, Bermejo, P Garcia, Perez, S, Carrillo, P Mulero, Vallejo, E Crespo, Piñero, M Ruiz, Mesonero, L Lopez, Muñoz, F J Reyes, Brekenfeld, C, Buhk, J-H, Krützelmann, A, Thomalla, G, Cheng, B, Beck, C, Hoppe, J, Goebell, E, Holst, B, Grzyska, U, Wortmann, G, Starkman, S, Duckwiler, G, Jahan, R, Rao, N, Sheth, S, Ng, K, Noorian, A, Szeder, V, Nour, M, McManus, M, Huang, J, Tarpley, J, Tateshima, S, Gonzalez, N, Ali, L, Liebeskind, D, Hinman, J, Calderon-Arnulphi, M, Liang, C, Guzy, J, Yavagal, D R, Koch, S, DeSousa, K, Gordon-Perue, G, Elhammady, M, Peterson, E, Pandey, V, Dharmadhikari, S, Khandelwal, P, Malik, A, Pafford, R, Gonzalez, P, Ramdas, K, Andersen, G, Damgaard, D, Von Weitzel-Mudersbach, P, Simonsen, C, Ayudarte, N Ruiz de Morales, Poulsen, M, Sørensen, L, Karabegovich, S, Hjørringgaard, M, Hjort, N, Harbo, T, Sørensen, K, Deshaies, E, Padalino, D, Swarnkar, A, Latorre, J G, Elnour, E, El-Zammar, Z, Villwock, M, Farid, H, Balgude, A, Cross, L, Hansen, K, Holtmannspötter, M, Kondziella, D, Hoejgaard, J, Taudorf, S, Soendergaard, H, Wagner, A, Cronquist, M, Stavngaard, T, Cortsen, M, Krarup, L H, Hyldal, T, Haring, H-P, Guggenberger, S, Hamberger, M, Trenkler, J, Sonnberger, M, Nussbaumer, K, Dominger, C, Bach, E, Jagadeesan, B D, Taylor, R, Kim, J, Shea, K, Tummala, R, Zacharatos, H, Sandhu, D, Ezzeddine, M, Grande, A, Hildebrandt, D, Miller, K, Scherber, J, Hendrickson, A, Jumaa, M, Zaidi, S, Hendrickson, T, Snyder, V, Killer-Oberpfalzer, M, Mutzenbach, J, Weymayr, F, Broussalis, E, Stadler, K, Jedlitschka, A, Malek, A, Mueller-Kronast, N, Beck, P, Martin, C, Summers, D, Day, J, Bettinger, I, Holloway, W, Olds, K, Arkin, S, Akhtar, N, Boutwell, C, Crandall, S, Schwartzman, M, Weinstein, C, Brion, B, Prothmann, S, Kleine, J, Kreiser, K, Boeckh-Behrens, T, Poppert, H, Wunderlich, S, Koch, M L, Biberacher, V, Huberle, A, Gora-Stahlberg, G, Knier, B, Meindl, T, Utpadel-Fischler, D, Zech, M, Kowarik, M, Seifert, C, Schwaiger, B, Puri, A, Hou, S, Wakhloo, A, Moonis, M, Henniger, N, Goddeau, R, Massari, F, Minaeian, A, Lozano, J D, Ramzan, M, Stout, C, Patel, A, Tunguturi, A, Onteddu, S, Carandang, R, Howk, M, University of California [Los Angeles] (UCLA), University of California, Département de Neuroradiologie[Montpellier], Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and CHU Toulouse [Toulouse]
Subjects: Male, medicine.medical_specialty, Solitaire Cryptographic Algorithm, Randomization, Medizin, 610 Medicine & health, Brain Ischemia, law.invention, Fibrinolytic Agents, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Randomized controlled trial, Modified Rankin Scale, law, medicine, Humans, Intravenous tissue plasminogen activator, Stroke, Aged, Thrombectomy, Stent retriever, Groin, business.industry, Endovascular Procedures, General Medicine, Middle Aged, medicine.disease, Combined Modality Therapy, 3. Good health, Surgery, Treatment Outcome, medicine.anatomical_structure, Tissue Plasminogen Activator, Acute Disease, Administration, Intravenous, Female, Stents, business
Abstract: BACKGROUND: Among patients with acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, less than 40% regain functional independence when treated with intravenous tissue plasminogen activator (t-PA) alone. Thrombectomy with the use of a stent retriever, in addition to intravenous t-PA, increases reperfusion rates and may improve long-term functional outcome.METHODS: We randomly assigned eligible patients with stroke who were receiving or had received intravenous t-PA to continue with t-PA alone (control group) or to undergo endovascular thrombectomy with the use of a stent retriever within 6 hours after symptom onset (intervention group). Patients had confirmed occlusions in the proximal anterior intracranial circulation and an absence of large ischemic-core lesions. The primary outcome was the severity of global disability at 90 days, as assessed by means of the modified Rankin scale (with scores ranging from 0 [no symptoms] to 6 [death]).RESULTS: The study was stopped early because of efficacy. At 39 centers, 196 patients underwent randomization (98 patients in each group). In the intervention group, the median time from qualifying imaging to groin puncture was 57 minutes, and the rate of substantial reperfusion at the end of the procedure was 88%. Thrombectomy with the stent retriever plus intravenous t-PA reduced disability at 90 days over the entire range of scores on the modified Rankin scale (PCONCLUSIONS: In patients receiving intravenous t-PA for acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, thrombectomy with a stent retriever within 6 hours after onset improved functional outcomes at 90 days. (Funded by Covidien; SWIFT PRIME ClinicalTrials.gov number, NCT01657461.).
Published: 2015

32. IFN-γ and TNF-α Pre-licensing Protects Mesenchymal Stromal Cells from the Pro-inflammatory Effects of Palmitate

Author: Lauren K. Boland, Alex J. Brown, James A. Ankrum, Anthony J. Burand, Devlin T. Boyt, and Vitor A. Lira
Subjects: 0301 basic medicine, Stromal cell, endocrine system diseases, medicine.medical_treatment, Palmitates, Inflammation, Protective Agents, Peripheral blood mononuclear cell, Cell therapy, Immunomodulation, 03 medical and health sciences, Interferon-gamma, Drug Discovery, Genetics, medicine, Humans, Molecular Biology, Cells, Cultured, Cell Proliferation, Pharmacology, Cell Death, Chemistry, Tumor Necrosis Factor-alpha, Mesenchymal stem cell, nutritional and metabolic diseases, Mesenchymal Stem Cells, Janus Kinase 1, Janus Kinase 2, 030104 developmental biology, Cytokine, Glucose, Phenotype, Apoptosis, Cancer research, Molecular Medicine, Cytokines, Tumor necrosis factor alpha, Original Article, medicine.symptom, Inflammation Mediators, Energy Metabolism, Signal Transduction
Abstract: The use of mesenchymal stromal cell (MSC) therapy for the treatment of type 2 diabetes (T2D) and T2D complications is promising; however, the investigation of MSC function in the setting of T2D has not been thoroughly explored. In our current study, we investigated the phenotype and function of MSCs in a simulated in vitro T2D environment. We show that palmitate, but not glucose, exposure impairs MSC metabolic activity with moderate increases in apoptosis, while drastically affecting proliferation and morphology. In co-culture with peripheral blood mononuclear cells (PBMCs), we found that MSCs not only lose their normal suppressive ability in high levels of palmitate, but actively support and enhance inflammation, resulting in elevated PBMC proliferation and pro-inflammatory cytokine release. The pro-inflammatory effect of MSCs in palmitate was partially reversed via palmitate removal and fully reversed through pre-licensing MSCs with interferon-gamma and tumor necrosis factor alpha. Thus, palmitate, a specific metabolic factor enriched within the T2D environment, is a potent modulator of MSC immunosuppressive function, which may in part explain the depressed potency observed in MSCs isolated from T2D patients. Importantly, we have also identified a robust and durable pre-licensing regimen that protects MSC immunosuppressive function in the setting of T2D.
Published: 2017

33. Telephone-supported computerised cognitive–behavioural therapy: REEACT-2 large-scale pragmatic randomised controlled trial\ud

Author: Gilbody, S., Brabyn, S., Lovell, K., Kessler, D., Devlin, T., Smith, L., Araya, R., Barkham, M., Bower, P., Cooper, C., Knowles, S., Littlewood, E., Richards, D.A., Tallon, D., White, D., and Worthy, G.
Published: 2017

34. Effect of atorvastatin in elderly patients with a recent stroke or transient ischemic attack

Author: Chaturvedi, S, Zivin, J, Breazna, A, Amarenco, P, Callahan, A, Goldstein, LB, Hennerici, M, Sillesen, H, Rudolph, A, Welch, MA, SPARCL Investigators, Crimmins D, Davis S, Dimmitt S, Donnan G, Frayne J, Freilich D, Zagami A, Mikocki J, Schmidauer C, Schmidt R, De Bleecker J, Deceuninck F, Tack P, Thijs V, Gomes Fernandes J, Beaudry M, Cote R, Hoyte K, Lebrun LH, Mackey A, Sahlas D, Selchen D, Shuaib A, Spence JD, Teal P, Winger M, Matamala G, Cifkova R, Kalita Z, Rektor I, Rosolova H, Stipal R, Vaclavik D, Boysen G, Klingenberg H, Iversen, Sillesen H, Hillbom M, Kaste M, Numminen H, Pilke A, Salmivaara A, Sivenius J, Alamowitch S, Amarenco P, Boulliat J, De Broucker T, Chollet F, Mahagne MH, Milandre L, Moulin T, Bogdahn U, Diener HC, Dichgans M, Glahn J, Haberl R, Harms L, Hennerici MG, Knecht S, Kroczek G, Lichy C, Sander D, Schneider D, Kazis A, Karageorgiou C, Milonas I, Stathis P, Vogiatzoglou D, Bornstein N, Honigman S, Lampl Y, Streifler J, Capurso A, Comi G, Gandolfo C, Poloni M, Senin U, Rangel Guerra R, Boon AM, De Keyser JH, De Kort PL, Haas JA, Kamphuis DJ, Koudstaal PJ, Anderson N, Scott R, Singh G, Czlonkowska A, Drozdowski W, Gralewski Z, Kozubski W, Kuczynska Zardzewialy A, Podemski R, Stelmasiak Z, Szczudlik A, Da Costa Correia C, Ferro J, Salgueiro e. Cunha L, Lietava J, Raslova K, Carr J, Gardiner J, Kruger A, Alvarez Sabin J, Chamorro A, Diez Tejedor E, Fernández O, Trejo Gabriel y. Galán J, González Marcos J, Egido Herrero J, Jiménez Martínez M, Lago Martin A, Mostacero Miguel E, Vivancos Mora J, Moltó J, Viguera Romero J, Cuartero Rodriguez E, Rodriguez F, Serena J, Laska AC, Leijd B, Strand T, Terent A, Waegner A, Wallén T, Baumgartner R, Bogousslavsky J, Hungerbühler H, Lyrer P, Mattle H, Bath PM, Ekpo EB, Freeman A, Lees KR, MacLeod MJ, MacWalter RS, Sharma AK, Shetty HG, Albers G, Altafullah I, Benavente O, Book D, Broderick J, Callahan A. 3rd, Calder C, Carlini W, Chaturvedi S, Chippendale T, Clark W, Coull B, Davis P, Devlin T, Dick A, Dooneief G, Duff R, Estronza N, Forteza A, Frankel M, Frey J, Friday G, Graham G, Goldstein J, Hammer M, Harris J, Harper W, Hendin B, Hendin D, Hinton R, Hollander J, Hughes R, Kasner S, Kent T, Kim L, Kirshner H, LaMonte M, Ledbetter L, Lee Kwen P, Levin K, Libman R, Matlock J, McDowell P, McGee F. Jr, Meyer B, Minagar A, Moussouttas M, Munson R, Nash M, Nassief A, Orr S, Ratinov G, Salanga V, Silliman S, Singer R, Smith D, Sullivan H, Tietjen G, Thaler D, Tuchman M, Uskavitch D, Verro P, Vicari R, Weinstein R, Wilterdink J, Zweifler R, De Bastos M., FERRARESE, CARLO, Chaturvedi, S, Zivin, J, Breazna, A, Amarenco, P, Callahan, A, Goldstein, L, Hennerici, M, Sillesen, H, Rudolph, A, Welch, M, Sparcl, I, Crimmins, D, Davis, S, Dimmitt, S, Donnan, G, Frayne, J, Freilich, D, Zagami, A, Mikocki, J, Schmidauer, C, Schmidt, R, De Bleecker, J, Deceuninck, F, Tack, P, Thijs, V, Gomes Fernandes, J, Beaudry, M, Cote, R, Hoyte, K, Lebrun, L, Mackey, A, Sahlas, D, Selchen, D, Shuaib, A, Spence, J, Teal, P, Winger, M, Matamala, G, Cifkova, R, Kalita, Z, Rektor, I, Rosolova, H, Stipal, R, Vaclavik, D, Boysen, G, Klingenberg, H, Iversen, Hillbom, M, Kaste, M, Numminen, H, Pilke, A, Salmivaara, A, Sivenius, J, Alamowitch, S, Boulliat, J, De Broucker, T, Chollet, F, Mahagne, M, Milandre, L, Moulin, T, Bogdahn, U, Diener, H, Dichgans, M, Glahn, J, Haberl, R, Harms, L, Knecht, S, Kroczek, G, Lichy, C, Sander, D, Schneider, D, Kazis, A, Karageorgiou, C, Milonas, I, Stathis, P, Vogiatzoglou, D, Bornstein, N, Honigman, S, Lampl, Y, Streifler, J, Capurso, A, Comi, G, Ferrarese, C, Gandolfo, C, Poloni, M, Senin, U, Rangel Guerra, R, Boon, A, De Keyser, J, De Kort, P, Haas, J, Kamphuis, D, Koudstaal, P, Anderson, N, Scott, R, Singh, G, Czlonkowska, A, Drozdowski, W, Gralewski, Z, Kozubski, W, Kuczynska Zardzewialy, A, Podemski, R, Stelmasiak, Z, Szczudlik, A, Da Costa Correia, C, Ferro, J, Salgueiro e., C, Lietava, J, Raslova, K, Carr, J, Gardiner, J, Kruger, A, Alvarez Sabin, J, Chamorro, A, Diez Tejedor, E, Fernández, O, Trejo Gabriel y., G, González Marcos, J, Egido Herrero, J, Jiménez Martínez, M, Lago Martin, A, Mostacero Miguel, E, Vivancos Mora, J, Moltó, J, Viguera Romero, J, Cuartero Rodriguez, E, Rodriguez, F, Serena, J, Laska, A, Leijd, B, Strand, T, Terent, A, Waegner, A, Wallén, T, Baumgartner, R, Bogousslavsky, J, Hungerbühler, H, Lyrer, P, Mattle, H, Bath, P, Ekpo, E, Freeman, A, Lees, K, Macleod, M, Macwalter, R, Sharma, A, Shetty, H, Albers, G, Altafullah, I, Benavente, O, Book, D, Broderick, J, Callahan A., 3, Calder, C, Carlini, W, Chippendale, T, Clark, W, Coull, B, Davis, P, Devlin, T, Dick, A, Dooneief, G, Duff, R, Estronza, N, Forteza, A, Frankel, M, Frey, J, Friday, G, Graham, G, Goldstein, J, Hammer, M, Harris, J, Harper, W, Hendin, B, Hendin, D, Hinton, R, Hollander, J, Hughes, R, Kasner, S, Kent, T, Kim, L, Kirshner, H, Lamonte, M, Ledbetter, L, Lee Kwen, P, Levin, K, Libman, R, Matlock, J, Mcdowell, P, McGee F., J, Meyer, B, Minagar, A, Moussouttas, M, Munson, R, Nash, M, Nassief, A, Orr, S, Ratinov, G, Salanga, V, Silliman, S, Singer, R, Smith, D, Sullivan, H, Tietjen, G, Thaler, D, Tuchman, M, Uskavitch, D, Verro, P, Vicari, R, Weinstein, R, Wilterdink, J, Zweifler, R, and De Bastos, M
Subjects: Male, medicine.medical_specialty, Atorvastatin, medicine.medical_treatment, Coronary Disease, Pyrrole, Revascularization, Risk Assessment, Cohort Studies, Coronary artery disease, Internal medicine, Anticholesteremic Agent, Myocardial Revascularization, medicine, Clinical endpoint, Humans, Pyrroles, Age Factor, cardiovascular diseases, Stroke, Aged, Cerebral infarction, business.industry, Anticholesteremic Agents, Hazard ratio, Age Factors, Cholesterol, LDL, Middle Aged, medicine.disease, Surgery, Heptanoic Acid, Heptanoic Acids, Ischemic Attack, Transient, Cohort, Cardiology, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitor, Neurology (clinical), Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cohort Studie, business, Human, medicine.drug
Abstract: BACKGROUND: It is unclear whether patients age 65 years and over with a recent stroke or TIA benefit from statin treatment to a similar degree as younger patients. METHODS: The 4,731 patient cohort in the SPARCL study was divided into an elderly group (65 and over) and a younger group. The primary endpoint (fatal or nonfatal stroke) and secondary endpoints were analyzed, with calculation of the hazard ratio (HR) and p values from a Cox regression model. RESULTS: There were 2,249 patients in the elderly group and 2,482 in the younger group. The baseline LDL (133 mg/dL) and total cholesterol were comparable in the two groups. The elderly and younger groups had a 61.4 mg/dL and 58.7 mg/dL decrease in mean LDL during the trial. The primary endpoint was reduced by 26% in younger patients (HR 0.74, 0.57-0.96, p = 0.02) and by 10% in elderly subjects (HR 0.90, 0.73-1.11, p = 0.33). A test of heterogeneity for a treatment-age interaction was not significant (p = 0.52). The risk of stroke or TIA (HR 0.79, p = 0.01), major coronary events (HR 0.68, p = 0.035), any coronary heart disease event (HR 0.61, p = 0.0006), and revascularization procedures (HR 0.55, p = 0.0005) was reduced in the elderly group. CONCLUSIONS: There was no heterogeneity in the stroke reduction seen with atorvastatin in the elderly and younger groups. Cardiac events and revascularization procedures were also lower in both the elderly and younger subgroups treated with atorvastatin. These results support the use of atorvastatin in elderly patients with recent stroke or TIA.
Published: 2008

35. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

Author: Román, Luis San, primary, Menon, Bijoy K, additional, Blasco, Jordi, additional, Hernández-Pérez, María, additional, Dávalos, Antoni, additional, Majoie, Charles B L M, additional, Campbell, Bruce C V, additional, Guillemin, Francis, additional, Lingsma, Hester, additional, Anxionnat, René, additional, Epstein, Jonathan, additional, Saver, Jeffrey L, additional, Marquering, Henk, additional, Wong, John H, additional, Lopes, Demetrius, additional, Reimann, Gernot, additional, Desal, Hubert, additional, Dippel, Diederik W J, additional, Coutts, Shelagh, additional, du Mesnil de Rochemont, Richard, additional, Yavagal, Dileep, additional, Ferre, Jean Christophe, additional, Roos, Yvo B W E M, additional, Liebeskind, David S, additional, Lenthall, Robert, additional, Molina, Carlos, additional, Al Ajlan, Fahad S, additional, Reddy, Vivek, additional, Dowlatshahi, Dar, additional, Sourour, Nader-Antoine, additional, Oppenheim, Catherine, additional, Mitha, Alim P, additional, Davis, Stephen M, additional, Weimar, Christian, additional, van Oostenbrugge, Robert J, additional, Cobo, Erik, additional, Kleinig, Timothy J, additional, Donnan, Geoffrey A, additional, van der Lugt, Aad, additional, Demchuk, Andrew M, additional, Berkhemer, Olvert A, additional, Boers, Anna M M, additional, Ford, Gary A, additional, Muir, Keith W, additional, Brown, B Scott, additional, Jovin, Tudor, additional, van Zwam, Wim H, additional, Mitchell, Peter J, additional, Hill, Michael D, additional, White, Phil, additional, Bracard, Serge, additional, Goyal, Mayank, additional, Fransen, Puck SS, additional, Beumer, Debbie, additional, van den Berg, Lucie A, additional, Lingsma, Hester F, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, 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additional, Poon, W, additional, Campbell, N, additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez-Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, 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Christopher R, additional, Ang, Timothy, additional, Spratt, Neil, additional, Kaauwai, Lara, additional, Badve, Monica, additional, Rice, Henry, additional, de Villiers, Laetitia, additional, Barber, P. Alan, additional, McGuinness, Ben, additional, Hope, Ayton, additional, Moriarty, Maurice, additional, Bennett, Patricia, additional, Wong, Andrew, additional, Coulthard, Alan, additional, Lee, Andrew, additional, Jannes, Jim, additional, Field, Deborah, additional, Sharma, Gagan, additional, Salinas, Simon, additional, Cowley, Elise, additional, Snow, Barry, additional, Kolbe, John, additional, Stark, Richard, additional, King, John, additional, Macdonnell, Richard, additional, Attia, John, additional, D'Este, Cate, additional, Diener, Hans-Christoph, additional, Levy, Elad I., additional, Bonafé, Alain, additional, Mendes Pereira, Vitor, additional, Jahan, Reza, additional, Albers, Gregory W., additional, Cognard, Christophe, additional, Cohen, David J., additional, Hacke, Werner, additional, Jansen, Olav, additional, Jovin, Tudor G., additional, Mattle, Heinrich P., additional, Nogueira, Raul G., additional, Siddiqui, Adnan H., additional, Yavagal, Dileep R., additional, von Kummer, 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additional, Rao, N, additional, Sheth, S, additional, Ng, K, additional, Noorian, A, additional, Szeder, V, additional, Nour, M, additional, McManus, M, additional, Huang, J, additional, Tarpley, J, additional, Tateshima, S, additional, Gonzalez, N, additional, Ali, L, additional, Liebeskind, D, additional, Hinman, J, additional, Calderon-Arnulphi, M, additional, Liang, C, additional, Guzy, J, additional, Koch, S, additional, DeSousa, K, additional, Gordon-Perue, G, additional, Elhammady, M, additional, Peterson, E, additional, Pandey, V, additional, Dharmadhikari, S, additional, Khandelwal, P, additional, Malik, A, additional, Pafford, R, additional, Gonzalez, P, additional, Ramdas, K, additional, Andersen, G, additional, Damgaard, D, additional, Von Weitzel-Mudersbach, P, additional, Simonsen, C, additional, Ruiz de Morales Ayudarte, N, additional, Poulsen, M, additional, Sørensen, L, additional, Karabegovich, S, additional, Hjørringgaard, M, additional, Hjort, N, additional, Harbo, T, additional, Sørensen, K, additional, Deshaies, E, additional, Padalino, D, additional, Swarnkar, A, additional, Latorre, JG, additional, Elnour, E, additional, El-Zammar, Z, additional, Villwock, M, additional, Farid, H, additional, Balgude, A, additional, Cross, L, additional, Hansen, K, additional, Holtmannspötter, M, additional, Kondziella, D, additional, Hoejgaard, J, additional, Taudorf, S, additional, Soendergaard, H, additional, Wagner, A, additional, Cronquist, M, additional, Stavngaard, T, additional, Cortsen, M, additional, Krarup, LH, additional, Hyldal, T, additional, Haring, H-P, additional, Guggenberger, S, additional, Hamberger, M, additional, Trenkler, J, additional, Sonnberger, M, additional, Nussbaumer, K, additional, Dominger, C, additional, Bach, E, additional, Jagadeesan, BD, additional, Taylor, R, additional, Kim, J, additional, Shea, K, additional, Tummala, R, additional, Zacharatos, H, additional, Sandhu, D, additional, Ezzeddine, M, additional, Grande, A, additional, Hildebrandt, D, additional, Miller, K, additional, Scherber, J, additional, Hendrickson, A, additional, Jumaa, M, additional, Zaidi, S, additional, Hendrickson, T, additional, Snyder, V, additional, Killer-Oberpfalzer, M, additional, Mutzenbach, J, additional, Weymayr, F, additional, Broussalis, E, additional, Stadler, K, additional, Jedlitschka, A, additional, Malek, A, additional, Mueller-Kronast, N, additional, Beck, P, additional, Martin, C, additional, Summers, D, additional, Day, J, additional, Bettinger, I, additional, Holloway, W, additional, Olds, K, additional, Arkin, S, additional, Akhtar, N, additional, Boutwell, C, additional, Crandall, S, additional, Schwartzman, M, additional, Weinstein, C, additional, Brion, B, additional, Prothmann, S, additional, Kleine, J, additional, Kreiser, K, additional, Boeckh-Behrens, T, additional, Poppert, H, additional, Wunderlich, S, additional, Koch, ML, additional, Biberacher, V, additional, Huberle, A, additional, 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additional, Millán, M, additional, Muñoz, L, additional, Pérez de la Ossa, N, additional, Gomis, M, additional, Dorado, L, additional, López-Cancio, E, additional, Palomeras, E, additional, Munuera, J, additional, García Bermejo, P, additional, Remollo, S, additional, Castaño, C, additional, García-Sort, R, additional, Cuadras, P, additional, Puyalto, P, additional, Hernández-Pérez, M, additional, Jiménez, M, additional, Martínez-Piñeiro, A, additional, Lucente, G, additional, Dávalos, A, additional, Chamorro, A, additional, Urra, X, additional, Obach, V, additional, Cervera, A, additional, Amaro, S, additional, Llull, L, additional, Codas, J, additional, Balasa, M, additional, Navarro, J, additional, Ariño, H, additional, Aceituno, A, additional, Rudilosso, S, additional, Renu, A, additional, Macho, JM, additional, San Roman, L, additional, Blasco, J, additional, López, A, additional, Macías, N, additional, Cardona, P, additional, Quesada, H, additional, Rubio, F, additional, Cano, L, additional, Lara, B, additional, de Miquel, MA, additional, Aja, L, additional, Serena, J, additional, Cobo, E, additional, Albers, Gregory W, additional, Lees, Kennedy R, additional, Arenillas, J, additional, Roberts, R, additional, Al-Ajlan, F, additional, Zimmel, L, additional, Patel, S, additional, Martí-Fàbregas, J, additional, Salvat-Plana, M, additional, Bracard, S, additional, Ducrocq, Xavier, additional, Baillot, Pierre-Alexandre, additional, Barbier, Charlotte, additional, Derelle, Anne-Laure, additional, Lacour, Jean-Christophe, additional, Richard, Sébastien, additional, Samson, Yves, additional, Sourour, Nader, additional, Baronnet-Chauvet, Flore, additional, Clarencon, Frédéric, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Di Maria, Federico, additional, Le Bouc, Raphael, additional, Leger, Anne, additional, Mutlu, Gurkan, additional, Rosso, Charlotte, additional, Szatmary, Zoltan, additional, Yger, Marion, additional, Zavanone, Chiara, additional, Bakchine, Serge, additional, Pierot, Laurent, additional, Caucheteux, Nathalie, additional, Estrade, Laurent, additional, Kadziolka, Krzysztof, additional, Leautaud, Alexandre, additional, Renkes, Céline, additional, Serre, Isabelle, additional, Guillon, Benoît, additional, Boutoleau-Bretonniere, Claire, additional, Daumas-Duport, Benjamin, additional, De Gaalon, Solène, additional, Derkinderen, Pascal, additional, Evain, Sarah, additional, Herisson, Fanny, additional, Laplaud, David-Axel, additional, Lebouvier, Thibaud, additional, Lintia-Gaultier, Alina, additional, Pouclet-Courtemanche, Hélène, additional, Rouaud, Tiphaine, additional, Rouaud Jaffrenou, Violaine, additional, Schunck, Aurélia, additional, Sevin-Allouet, Mathieu, additional, Toulgoat, Frederique, additional, Wiertlewski, Sandrine, additional, Gauvrit, Jean-Yves, additional, Ronziere, Thomas, additional, Cahagne, Vincent, additional, Ferre, Jean-Christophe, additional, Pinel, Jean-François, additional, Raoult, Hélène, additional, Mas, Jean-Louis, additional, Meder, Jean-François, additional, Al Najjar-Carpentier, Amen-Adam, additional, Birchenall, Julia, additional, Bodiguel, Eric, additional, Calvet, David, additional, Domigo, Valérie, additional, Godon-Hardy, Sylvie, additional, Guiraud, Vincent, additional, Lamy, Catherine, additional, Majhadi, Loubna, additional, Morin, Ludovic, additional, Naggara, Olivier, additional, Trystram, Denis, additional, Turc, Guillaume, additional, Berge, Jérôme, additional, Sibon, Igor, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Rouanet, François, additional, Debruxelles, Sabrina, additional, Kazadi, Annabelle, additional, Renou, Pauline, additional, Fleury, Olivier, additional, Pasco-Papon, Anne, additional, Dubas, Frédéric, additional, Caroff, Jildaz, additional, Godard Ducceschi, Sophie, additional, Hamon, Marie-Aurélie, additional, Lecluse, Alderic, additional, Marc, Guillaume, additional, Giroud, Maurice, additional, Ricolfi, Frédéric, additional, Bejot, Yannick, additional, Chavent, Adrien, additional, Gentil, Arnaud, additional, Kazemi, Apolline, additional, Osseby, Guy-Victor, additional, Voguet, Charlotte, additional, Mahagne, Marie-Hélène, additional, Sedat, Jacques, additional, Chau, Yves, additional, Suissa, Laurent, additional, Lachaud, Sylvain, additional, Houdart, Emmanuel, additional, Stapf, Christian, additional, Buffon Porcher, Frédérique, additional, Chabriat, Hugues, additional, Guedin, Pierre, additional, Herve, Dominique, additional, Jouvent, Eric, additional, Mawet, Jérôme, additional, Saint-Maurice, Jean-Pierre, additional, Schneble, Hans-Martin, additional, Nighoghossian, Norbert, additional, Berhoune, Nadia-Nawel, additional, Bouhour, Françoise, additional, Cho, Tae-Hee, additional, Derex, Laurent, additional, Felix, Sandra, additional, Gervais-Bernard, Hélène, additional, Gory, Benjamin, additional, Manera, Luis, additional, Mechtouff, Laura, additional, Ritzenthaler, Thomas, additional, Riva, Roberto, additional, Salaris Silvio, Fabrizio, additional, Tilikete, Caroline, additional, Blanc, Raphael, additional, Obadia, Michaël, additional, Bartolini, Mario Bruno, additional, Gueguen, Antoine, additional, Piotin, Michel, additional, Pistocchi, Silvia, additional, Redjem, Hocine, additional, Drouineau, Jacques, additional, Neau, Jean-Philippe, additional, Godeneche, Gaelle, additional, Lamy, Matthias, additional, Marsac, Emilia, additional, Velasco, Stephane, additional, Clavelou, Pierre, additional, Chabert, Emmanuel, additional, Bourgois, Nathalie, additional, Cornut-Chauvinc, Catherine, additional, Ferrier, Anna, additional, Gabrillargues, Jean, additional, Jean, Betty, additional, Marques, Anna-Raquel, additional, Vitello, Nicolas, additional, Detante, Olivier, additional, Barbieux, Marianne, additional, Boubagra, Kamel, additional, Favre Wiki, Isabelle, additional, Garambois, Katia, additional, Tahon, Florence, additional, Ashok, Vasdev, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Lapergue, Bertrand, additional, Bourdain, Frédéric, additional, Evrard, Serge, additional, Graveleau, Philippe, additional, Decroix, Jean Pierre, additional, Wang, Adrien, additional, Sellal, François, additional, Ahle, Guido, additional, Carelli, Gabriela, additional, Dugay, Marie-Hélène, additional, Gaultier, Claude, additional, Lebedinsky, Ariel Pablo, additional, Lita, Lavinia, additional, Musacchio, Raul Mariano, additional, Renglewicz-Destuynder, Catherine, additional, Tournade, Alain, additional, Vuillemet, Françis, additional, Montoro, Francisco Macian, additional, Mounayer, Charbel, additional, Faugeras, Frederic, additional, Gimenez, Laetitia, additional, Labach, Catherine, additional, Lautrette, Géraldine, additional, Denier, Christian, additional, Saliou, Guillaume, additional, Chassin, Olivier, additional, Dussaule, Claire, additional, Melki, Elsa, additional, Ozanne, Augustin, additional, Puccinelli, Francesco, additional, Sachet, Marina, additional, Sarov, Mariana, additional, Bonneville, Jean-François, additional, Moulin, Thierry, additional, Biondi, Alessandra, additional, De Bustos Medeiros, Elisabeth, additional, Vuillier, Fabrice, additional, Courtheoux, Patrick, additional, Viader, Fausto, additional, Apoil-Brissard, Marion, additional, Bataille, Mathieu, additional, Bonnet, Anne-Laure, additional, Cogez, Julien, additional, Touze, Emmanuel, additional, Leclerc, Xavier, additional, Leys, Didier, additional, Aggour, Mohamed, additional, Aguettaz, Pierre, additional, Bodenant, Marie, additional, Cordonnier, Charlotte, additional, Deplanque, Dominique, additional, Girot, Marie, additional, Henon, Hilde, additional, Kalsoum, Erwah, additional, Lucas, Christian, additional, Pruvo, Jean-Pierre, additional, Zuniga, Paolo, additional, Arquizan, Caroline, additional, Costalat, Vincent, additional, Machi, Paolo, additional, Mourand, Isabelle, additional, Riquelme, Carlos, additional, Bounolleau, Pierre, additional, Arteaga, Charles, additional, Faivre, Anthony, additional, Bintner, Marc, additional, Tournebize, Patrice, additional, Charlin, Cyril, additional, Darcel, Françoise, additional, Gauthier-Lasalarie, Pascale, additional, Jeremenko, Marcia, additional, Mouton, Servane, additional, Zerlauth, Jean-Baptiste, additional, Lamy, Chantal, additional, Hervé, Deramond, additional, Hassan, Hosseini, additional, Gaston, André, additional, Barral, Francis-Guy, additional, Garnier, Pierre, additional, Beaujeux, Rémy, additional, Wolff, Valérie, additional, Herbreteau, Denis, additional, Debiais, Séverine, additional, Murray, Alicia, additional, Ford, Gary, additional, White, Philip, additional, Brown, Martin M, additional, Clifton, Andy, additional, Freeman, Janet, additional, Ford, Ian, additional, Markus, Hugh, additional, Wardlaw, Joanna, additional, Molyneux, Andy, additional, Robinson, Thompson, additional, Lewis, Steff, additional, Norrie, John, additional, Robertson, Fergus, additional, Perry, Richard, additional, Dixit, Anand, additional, Cloud, Geoffrey, additional, Clifton, Andrew, additional, Madigan, Jeremy, additional, Roffe, Christine, additional, Nayak, Sanjeev, additional, Lobotesis, Kyriakos, additional, Smith, Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional
Published: 2018
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36. E-071 Using transcranial doppler ultrasound for the objective evaluation and prediction of endovascular treatment outcomes

Author: Thibeault, C, primary, Thorpe, S, additional, Wilk, S, additional, Devlin, T, additional, and Hamilton, R, additional
Published: 2018
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37. E-108 Aladin study: automated large artery occlusion detection in stroke imaging study – a multicenter analysis

Author: Barreira, C, primary, Bouslama, M, additional, Lim, J, additional, Al-Bayati, A, additional, Saleem, Y, additional, Devlin, T, additional, Haussen, D, additional, Froehler, M, additional, Grossberg, J, additional, Baxter, B, additional, Frankel, M, additional, and Nogueira, R, additional
Published: 2018
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38. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Author: Campbell, Bruce C V, primary, van Zwam, Wim H, additional, Goyal, Mayank, additional, Menon, Bijoy K, additional, Dippel, Diederik W J, additional, Demchuk, Andrew M, additional, Bracard, Serge, additional, White, Philip, additional, Dávalos, Antoni, additional, Majoie, Charles B L M, additional, van der Lugt, Aad, additional, Ford, Gary A, additional, de la Ossa, Natalia Pérez, additional, Kelly, Michael, additional, Bourcier, Romain, additional, Donnan, Geoffrey A, additional, Roos, Yvo B W E M, additional, Bang, Oh Young, additional, Nogueira, Raul G, additional, Devlin, Thomas G, additional, van den Berg, Lucie A, additional, Clarençon, Frédéric, additional, Burns, Paul, additional, Carpenter, Jeffrey, additional, Berkhemer, Olvert A, additional, Yavagal, Dileep R, additional, Pereira, Vitor Mendes, additional, Ducrocq, Xavier, additional, Dixit, Anand, additional, Quesada, Helena, additional, Epstein, Jonathan, additional, Davis, Stephen M, additional, Jansen, Olav, additional, Rubiera, Marta, additional, Urra, Xabier, additional, Micard, Emilien, additional, Lingsma, Hester F, additional, Naggara, Olivier, additional, Brown, Scott, additional, Guillemin, Francis, additional, Muir, Keith W, additional, van Oostenbrugge, Robert J, additional, Saver, Jeffrey L, additional, Jovin, Tudor G, additional, Hill, Michael D, additional, Mitchell, Peter J, additional, Fransen, Puck SS, additional, Beumer, Debbie, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, additional, Williams, J, additional, Wiegner, R, additional, Casaubon, LK, additional, Jaigobin, C, additional, del Campo, JM, additional, Elamin, E, additional, Schaafsma, JD, additional, Agid, R, additional, Farb, R, additional, ter Brugge, K, additional, Sapkoda, BL, additional, Baxter, BW, additional, Barton, K, additional, Knox, A, additional, Porter, A, additional, Sirelkhatim, A, additional, Devlin, T, additional, Dellinger, C, additional, Pitiyanuvath, N, additional, Patterson, J, additional, Nichols, J, additional, Quarfordt, S, additional, Calvert, J, additional, Hawk, H, additional, Fanale, C, additional, Bitner, A, additional, Novak, A, additional, Huddle, D, additional, Bellon, R, additional, Loy, D, additional, Wagner, J, additional, Chang, I, additional, Lampe, E, additional, Spencer, B, additional, Pratt, R, additional, Bartt, R, additional, Shine, S, additional, Dooley, G, additional, Nguyen, T, additional, Whaley, M, additional, McCarthy, K, additional, Teitelbaum, J, additional, Poon, W, additional, Campbell, N, additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez- Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, P, additional, Golob, D, additional, Gladstone, D, additional, Boyle, K, additional, Boulos, M, additional, Hopyan, J, additional, Yang, V, additional, Da Costa, L, additional, Holmstedt, CA, additional, Turk, AS, additional, Navarro, R, additional, Jauch, E, additional, Ozark, S, additional, Turner, R, additional, Phillips, S, additional, Shankar, J, additional, Jarrett, J, additional, Gubitz, G, additional, Maloney, W, additional, Vandorpe, R, additional, Schmidt, M, additional, Heidenreich, J, additional, Hunter, G, additional, Kelly, M, additional, Whelan, R, additional, Peeling, L, additional, Burns, PA, additional, Hunter, A, additional, Wiggam, I, additional, Kerr, E, additional, Watt, M, additional, Fulton, A, additional, Gordon, P, additional, Rennie, I, additional, Flynn, P, additional, Smyth, G, additional, O'Leary, S, additional, Gentile, N, additional, Linares, G, additional, McNelis, P, additional, Erkmen, K, additional, Katz, P, additional, Azizi, A, additional, Weaver, M, additional, Jungreis, C, additional, Faro, S, additional, Shah, P, additional, Reimer, H, additional, Kalugdan, V, additional, Saposnik, G, additional, Bharatha, A, additional, Li, Y, additional, Kostyrko, P, additional, Marotta, T, additional, Montanera, W, additional, Sarma, D, additional, Selchen, D, additional, Spears, J, additional, Heo, JH, additional, Jeong, K, additional, Kim, DJ, additional, Kim, BM, additional, Kim, YD, additional, Song, D, additional, Lee, K-J, additional, Yoo, J, additional, Bang, OY, additional, Rho, S, additional, Lee, J, additional, Jeon, P, additional, Kim, KH, additional, Cha, J, additional, Kim, SJ, additional, Ryoo, S, additional, Lee, MJ, additional, Sohn, S-I, additional, Kim, C-H, additional, Ryu, H-G, additional, Hong, J-H, additional, Chang, H-W, additional, Lee, C-Y, additional, Rha, J, additional, Campbell, Bruce CV, additional, Churilov, Leonid, additional, Yan, Bernard, additional, Dowling, Richard, additional, Yassi, Nawaf, additional, Oxley, Thomas J, additional, Wu, Teddy Y, additional, Silver, Gabriel, additional, McDonald, Amy, additional, McCoy, Rachael, additional, Kleinig, Timothy J, additional, Scroop, Rebecca, additional, Dewey, Helen M, additional, Simpson, Marion, additional, Brooks, Mark, additional, Coulton, Bronwyn, additional, Krause, Martin, additional, Harrington, Timothy J, additional, Steinfort, Brendan, additional, Faulder, Kenneth, additional, Priglinger, Miriam, additional, Day, Susan, additional, Phan, Thanh, additional, Chong, Winston, additional, Holt, Michael, additional, Chandra, Ronil V, additional, Ma, Henry, additional, Young, Dennis, additional, Wong, Kitty, additional, Wijeratne, Tissa, additional, Tu, Hans, additional, Mackay, Elizabeth, additional, Celestino, Sherisse, additional, Bladin, Christopher F, additional, Loh, Poh Sien, additional, Gilligan, Amanda, additional, Ross, Zofia, additional, Coote, Skye, additional, Frost, Tanya, additional, Parsons, Mark W, additional, Miteff, Ferdinand, additional, Levi, Christopher R, additional, Ang, Timothy, additional, Spratt, Neil, additional, Kaauwai, Lara, additional, Badve, Monica, additional, Rice, Henry, additional, de Villiers, Laetitia, additional, Barber, P. Alan, additional, McGuinness, Ben, additional, Hope, Ayton, additional, Moriarty, Maurice, additional, Bennett, Patricia, additional, Wong, Andrew, additional, Coulthard, Alan, additional, Lee, Andrew, additional, Jannes, Jim, additional, Field, Deborah, additional, Sharma, Gagan, additional, Salinas, Simon, additional, Cowley, Elise, additional, Snow, Barry, additional, Kolbe, John, additional, Stark, Richard, additional, King, John, additional, Macdonnell, Richard, additional, Attia, John, additional, D'Este, Cate, additional, Diener, Hans-Christoph, additional, Levy, Elad I., additional, Bonafé, Alain, additional, Mendes Pereira, Vitor, additional, Jahan, Reza, additional, Albers, Gregory W., additional, Cognard, Christophe, additional, Cohen, David J., additional, Hacke, Werner, additional, Jovin, Tudor G., additional, Mattle, Heinrich P., additional, Nogueira, Raul G., additional, Siddiqui, Adnan H., additional, Yavagal, Dileep R., additional, von Kummer, Rüdiger, additional, 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additional, Meindl, T, additional, Utpadel-Fischler, D, additional, Zech, M, additional, Kowarik, M, additional, Seifert, C, additional, Schwaiger, B, additional, Puri, A, additional, Hou, S, additional, Wakhloo, A, additional, Moonis, M, additional, Henninger, N, additional, Goddeau, R, additional, Massari, F, additional, Minaeian, A, additional, Lozano, JD, additional, Ramzan, M, additional, Stout, C, additional, Patel, A, additional, Tunguturi, A, additional, Onteddu, S, additional, Carandang, R, additional, Howk, M, additional, Ribó, M, additional, Sanjuan, E, additional, Rubiera, M, additional, Pagola, J, additional, Flores, A, additional, Muchada, M, additional, Meler, P, additional, Huerga, E, additional, Gelabert, S, additional, Coscojuela, P, additional, Tomasello, A, additional, Rodriguez, D, additional, Santamarina, E, additional, Maisterra, O, additional, Boned, S, additional, Seró, L, additional, Rovira, A, additional, Molina, CA, additional, Millán, M, additional, Muñoz, L, additional, Pérez de la Ossa, N, additional, Gomis, M, additional, Dorado, L, additional, López-Cancio, E, additional, Palomeras, E, additional, Munuera, J, additional, García Bermejo, P, additional, Remollo, S, additional, Castaño, C, additional, García-Sort, R, additional, Cuadras, P, additional, Puyalto, P, additional, Hernández-Pérez, M, additional, Jiménez, M, additional, Martínez-Piñeiro, A, additional, Lucente, G, additional, Dávalos, A, additional, Chamorro, A, additional, Urra, X, additional, Obach, V, additional, Cervera, A, additional, Amaro, S, additional, Llull, L, additional, Codas, J, additional, Balasa, M, additional, Navarro, J, additional, Ariño, H, additional, Aceituno, A, additional, Rudilosso, S, additional, Renu, A, additional, Macho, JM, additional, San Roman, L, additional, Blasco, J, additional, López, A, additional, Macías, N, additional, Cardona, P, additional, Quesada, H, additional, Rubio, F, additional, Cano, L, additional, Lara, B, additional, de Miquel, MA, additional, Aja, L, additional, Serena, J, additional, Cobo, E, additional, Albers, Gregory W, additional, Lees, Kennedy R, additional, Arenillas, J, additional, Roberts, R, additional, Al-Ajlan, F, additional, Zimmel, L, additional, Patel, S, additional, Martí-Fàbregas, J, additional, Salvat-Plana, M, additional, Bracard, S, additional, Anxionnat, René, additional, Baillot, Pierre-Alexandre, additional, Barbier, Charlotte, additional, Derelle, Anne-Laure, additional, Lacour, Jean-Christophe, additional, Richard, Sébastien, additional, Samson, Yves, additional, Sourour, Nader, additional, Baronnet-Chauvet, Flore, additional, Clarencon, Frédéric, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Di Maria, Federico, additional, Le Bouc, Raphael, additional, Leger, Anne, additional, Mutlu, Gurkan, additional, Rosso, Charlotte, additional, Szatmary, Zoltan, additional, Yger, Marion, additional, Zavanone, Chiara, additional, Bakchine, Serge, additional, Pierot, Laurent, additional, Caucheteux, Nathalie, additional, Estrade, Laurent, additional, Kadziolka, Krzysztof, additional, Leautaud, Alexandre, additional, Renkes, Céline, additional, Serre, Isabelle, additional, Desal, Hubert, additional, Guillon, Benoît, additional, Boutoleau-Bretonniere, Claire, additional, Daumas-Duport, Benjamin, additional, De Gaalon, Solène, additional, Derkinderen, Pascal, additional, Evain, Sarah, additional, Herisson, Fanny, additional, Laplaud, David-Axel, additional, Lebouvier, Thibaud, additional, Lintia-Gaultier, Alina, additional, Pouclet-Courtemanche, Hélène, additional, Rouaud, Tiphaine, additional, Rouaud Jaffrenou, Violaine, additional, Schunck, Aurélia, additional, Sevin-Allouet, Mathieu, additional, Toulgoat, Frederique, additional, Wiertlewski, Sandrine, additional, Gauvrit, Jean-Yves, additional, Ronziere, Thomas, additional, Cahagne, Vincent, additional, Ferre, Jean-Christophe, additional, Pinel, Jean-François, additional, Raoult, Hélène, additional, Mas, Jean-Louis, additional, Meder, Jean-François, additional, Al Najjar-Carpentier, Amen-Adam, additional, Birchenall, Julia, additional, Bodiguel, Eric, additional, Calvet, David, additional, Domigo, Valérie, additional, Godon-Hardy, Sylvie, additional, Guiraud, Vincent, additional, Lamy, Catherine, additional, Majhadi, Loubna, additional, Morin, Ludovic, additional, Trystram, Denis, additional, Turc, Guillaume, additional, Berge, Jérôme, additional, Sibon, Igor, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Rouanet, François, additional, Debruxelles, Sabrina, additional, Kazadi, Annabelle, additional, Renou, Pauline, additional, Fleury, Olivier, additional, Pasco-Papon, Anne, additional, Dubas, Frédéric, additional, Caroff, Jildaz, additional, Godard Ducceschi, Sophie, additional, Hamon, Marie-Aurélie, additional, Lecluse, Alderic, additional, Marc, Guillaume, additional, Giroud, Maurice, additional, Ricolfi, Frédéric, additional, Bejot, Yannick, additional, Chavent, Adrien, additional, Gentil, Arnaud, additional, Kazemi, Apolline, additional, Osseby, Guy-Victor, additional, Voguet, Charlotte, additional, Mahagne, Marie-Hélène, additional, Sedat, Jacques, additional, Chau, Yves, additional, Suissa, Laurent, additional, Lachaud, Sylvain, additional, Houdart, Emmanuel, additional, Stapf, Christian, additional, Buffon Porcher, Frédérique, additional, Chabriat, Hugues, additional, Guedin, Pierre, additional, Herve, Dominique, additional, Jouvent, Eric, additional, Mawet, Jérôme, additional, Saint-Maurice, Jean-Pierre, additional, Schneble, Hans-Martin, additional, Nighoghossian, Norbert, additional, Berhoune, Nadia-Nawel, additional, Bouhour, Françoise, additional, Cho, Tae-Hee, additional, Derex, Laurent, additional, Felix, Sandra, additional, Gervais-Bernard, Hélène, additional, Gory, Benjamin, additional, Manera, Luis, additional, Mechtouff, Laura, additional, Ritzenthaler, Thomas, additional, Riva, Roberto, additional, Salaris Silvio, Fabrizio, additional, Tilikete, Caroline, additional, Blanc, Raphael, additional, Obadia, Michaël, additional, Bartolini, Mario Bruno, additional, Gueguen, Antoine, additional, Piotin, Michel, additional, Pistocchi, Silvia, additional, Redjem, Hocine, additional, Drouineau, Jacques, additional, Neau, Jean-Philippe, additional, Godeneche, Gaelle, additional, Lamy, Matthias, additional, Marsac, Emilia, additional, Velasco, Stephane, additional, Clavelou, Pierre, additional, Chabert, Emmanuel, additional, Bourgois, Nathalie, additional, Cornut-Chauvinc, Catherine, additional, Ferrier, Anna, additional, Gabrillargues, Jean, additional, Jean, Betty, additional, Marques, Anna-Raquel, additional, Vitello, Nicolas, additional, Detante, Olivier, additional, Barbieux, Marianne, additional, Boubagra, Kamel, additional, Favre Wiki, Isabelle, additional, Garambois, Katia, additional, Tahon, Florence, additional, Ashok, Vasdev, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Lapergue, Bertrand, additional, Bourdain, Frédéric, additional, Evrard, Serge, additional, Graveleau, Philippe, additional, Decroix, Jean Pierre, additional, Wang, Adrien, additional, Sellal, François, additional, Ahle, Guido, additional, Carelli, Gabriela, additional, Dugay, Marie-Hélène, additional, Gaultier, Claude, additional, Lebedinsky, Ariel Pablo, additional, Lita, Lavinia, additional, Musacchio, Raul Mariano, additional, Renglewicz-Destuynder, Catherine, additional, Tournade, Alain, additional, Vuillemet, Françis, additional, Montoro, Francisco Macian, additional, Mounayer, Charbel, additional, Faugeras, Frederic, additional, Gimenez, Laetitia, additional, Labach, Catherine, additional, Lautrette, Géraldine, additional, Denier, Christian, additional, Saliou, Guillaume, additional, Chassin, Olivier, additional, Dussaule, Claire, additional, Melki, Elsa, additional, Ozanne, Augustin, additional, Puccinelli, Francesco, additional, Sachet, Marina, additional, Sarov, Mariana, additional, Bonneville, Jean-François, additional, Moulin, Thierry, additional, Biondi, Alessandra, additional, De Bustos Medeiros, Elisabeth, additional, Vuillier, Fabrice, additional, Courtheoux, Patrick, additional, Viader, Fausto, additional, Apoil-Brissard, Marion, additional, Bataille, Mathieu, additional, Bonnet, Anne-Laure, additional, Cogez, Julien, additional, Touze, Emmanuel, additional, Leclerc, Xavier, additional, Leys, Didier, additional, Aggour, Mohamed, additional, Aguettaz, Pierre, additional, Bodenant, Marie, additional, Cordonnier, Charlotte, additional, Deplanque, Dominique, additional, Girot, Marie, additional, Henon, Hilde, additional, Kalsoum, Erwah, additional, Lucas, Christian, additional, Pruvo, Jean-Pierre, additional, Zuniga, Paolo, additional, Arquizan, Caroline, additional, Costalat, Vincent, additional, Machi, Paolo, additional, Mourand, Isabelle, additional, Riquelme, Carlos, additional, Bounolleau, Pierre, additional, Arteaga, Charles, additional, Faivre, Anthony, additional, Bintner, Marc, additional, Tournebize, Patrice, additional, Charlin, Cyril, additional, Darcel, Françoise, additional, Gauthier-Lasalarie, Pascale, additional, Jeremenko, Marcia, additional, Mouton, Servane, additional, Zerlauth, Jean-Baptiste, additional, Lamy, Chantal, additional, Hervé, Deramond, additional, Hassan, Hosseini, additional, Gaston, André, additional, Barral, Francis-Guy, additional, Garnier, Pierre, additional, Beaujeux, Rémy, additional, Wolff, Valérie, additional, Herbreteau, Denis, additional, Debiais, Séverine, additional, Murray, Alicia, additional, Ford, Gary, additional, Brown, Martin M, additional, Clifton, Andy, additional, Freeman, Janet, additional, Ford, Ian, additional, Markus, Hugh, additional, Wardlaw, Joanna, additional, Molyneux, Andy, additional, Robinson, Thompson, additional, Lewis, Steff, additional, Norrie, John, additional, Robertson, Fergus, additional, Perry, Richard, additional, Cloud, Geoffrey, additional, Clifton, Andrew, additional, Madigan, Jeremy, additional, Roffe, Christine, additional, Nayak, Sanjeev, additional, Lobotesis, Kyriakos, additional, Smith, Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional
Published: 2018
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39. New Measurements of Hyperon Magnetic and Electric Dipole Moments

Author: Sheaff, M., Grobel, R., Handler, R., Lundberg, B., March, R., Pondrom, L., Wilkinson, C., Cox, P. T., Overseth, O. E., Dukes, C., Dworkin, J., Beretvas, A., Devlin, T., Schachinger, L., Skubic, P., Deck, L., Luk, B., Rameika, R., Whitman, R., Heller, K., Bunce, G., Joseph, C., editor, and Soffer, J., editor
Published: 1981
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40. Limits on the Masses of Supersymmetric Particles from 1.8 TeV P—P Collisions

Author: The CDF Collaboration, Devlin, T., Kotthaus, Rainer, editor, and Kühn, Johann H., editor
Published: 1989
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41. Infarct in a New Territory After Treatment Administration in the ESCAPE Randomized Controlled Trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times)

Author: Ganesh, A, Al-Ajlan, F, Sabiq, F, Assis, Z, Rempel, J, Butcher, K, Thornton, J, Kelly, P, Roy, D, Poppe, A, Jovin, T, Devlin, T, Baxter, B, Krings, T, Casaubon, L, Frei, D, Choe, H, Tampieri, D, Teitelbaum, J, Lum, C, Mandzia, J, Phillips, S, Bang, O, Almekhlafi, M, Coutts, S, Barber, P, Sajobi, T, Demchuk, A, Eesa, M, Hill, M, Goyal, M, Menon, B, and Investigators, ESCAPE Trial
Subjects: medicine.medical_specialty, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Fibrinolytic Agents, Modified Rankin Scale, law, medicine, Humans, Thrombolytic Therapy, Advanced and Specialized Nursing, medicine.diagnostic_test, Cerebral infarction, business.industry, Magnetic resonance imaging, Odds ratio, Cerebral Infarction, medicine.disease, Confidence interval, Surgery, Clinical trial, Ostium, Tissue Plasminogen Activator, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract: Background and Purpose— Infarct in a new previously unaffected territory (INT) is a potential complication of endovascular treatment. We applied a recently proposed methodology to identify and classify INTs in the ESCAPE randomized controlled trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times). Methods— The core laboratory identified INTs on 24-hour follow-up imaging, blinded to treatment allocation, after assessing all baseline imaging. INTs were classified into 3 types (I–III) and 2 subtypes (A/B) based on size and if catheter manipulation was likely performed across the vessel territory ostium. Logistic regression was used to understand the effect of multiple a priori identified variables on INT occurrence. Ordinal logistic regression was used to analyze the effect of INTs on modified Rankin Scale shift at 90 days. Results— From 308 patients included, 14 INTs (4.5% overall; 2.8% on follow-up noncontrast computed tomography, 11.7% on follow-up magnetic resonance imaging) were identified (5.0% in endovascular treatment arm versus 4.0% in control arm [ P =0.7]). The use of intravenous alteplase was associated with a 68% reduction in the odds of INT occurrence (3.0% with versus 9.1% without; odds ratio, 0.32; 95% confidence interval, 0.11–0.96; adjusted for age, sex, and treatment type). No other variables were associated with INTs. INT occurrence was associated with reduced probability of good clinical outcome (common odds ratio, 0.25; 95% confidence interval, 0.09–0.74; adjusted for age, type of treatment, and follow-up scan). Conclusions— INTs are uncommon, detected more frequently on follow-up magnetic resonance imaging, and affect clinical outcome. In experienced centers, endovascular treatment is likely not causal, whereas intravenous alteplase may be therapeutic. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT01778335.
Published: 2016

42. Double diffraction dissociation at the Fermilab Tevatron collider

Author: Affolder, T., Akimoto, H., Akopian, A., Albrow, M. G., Amaral, P., Amidei, D., Anikeev, K., Antos, J., Apollinari, G., Arisawa, T., Asakawa, T., Ashmanskas, W., Azfar, F., Azzi-Bacchetta, P., Bacchetta, N., Bailey, M. W., Bailey, S., De Barbaro, P., Barbaro-Galtieri, A., Barnes, V. E., Barnett, B. A., Baroiant, S., Barone, M., Bauer, G., Bedeschi, F., Belforte, S., Bell, W. H., Bellettini, G., Bellinger, J., Benjamin, D., Bensinger, J., Beretvas, Andrew, Berge, J. P., Berryhill, J., Bhatti, A., Binkley, M., Bisello, D., Bishai, M., Blair, R. E., Blocker, C., Bloom, K., Blumenfeld, B., Blusk, S. R., Bocci, A., Bodek, A., Bokhari, W., Bolla, G., Bonushkin, Yu Ye, Borras, K., Bortoletto, D., Boudreau, J., Brandl, A., Van Den Brink, S., Bromberg, C., Brozovic, M., Bruner, N., Buckley-Geer, E., Budagov, J., Budd, H. S., Burkett, K., Busetto, G., Byon-Wagner, A., Byrum, K. L., Cabrera, S., Calafiura, P., Campbell, M., Carithers, W., Carlson, J., Carlsmith, D., Caskey, W., Castro, A., Cauz, D., Cerri, A., Chan, A. W., Chang, P. S., Chang, P. T., Chapman, J., Chen, C., Chen, Y. C., Cheng, M. -T, Chertok, M., Chiarelli, G., Chirikov-Zorin, I., Chlachidze, G., Chlebana, F., Christofek, L., Chu, M. L., Chung, Y. S., Ciobanu, C. I., Clark, A. G., Connolly, A., Convery, M., Conway, J., Cordelli, M., Cranshaw, J., Cropp, R., Culbertson, R., Dagenhart, D., D'Auria, S., DeJongh, F., Dell'Agnello, Simone, Dell'Orso, M., Demortier, L., Deninno, M., Derwent, P. F., Devlin, T., Dittmann, J. R., Dominguez, A., Donati, S., Done, J., D'Onofrio, M., Dorigo, T., Eddy, N., Einsweiler, K., Elias, John E., Engels Jr., E., Erbacher, R., Errede, D., Errede, S., Fan, Q., Feild, R. G., Fernandez, J. P., Ferretti, C., Field, R. D., Fiori, I., Flaugher, B., Foster, G. W., Franklin, M., Freeman, J., Friedman, J., Fukui, Y., Furic, I., Galeotti, S., Gallas, A., Gallinaro, M., Gao, T., Garcia-Sciveres, M., Garfinkel, A. F., Gatti, P., Gay, C., Gerdes, D. W., Giannetti, P., Glagolev, V., Glenzinski, D., Gold, M., Goldstein, J., Gorelov, I., Goshaw, A. T., Gotra, Y., Goulianos, Konstantin, Green, C., Grim, G., Gris, P., Groer, L., Grosso-Pilcher, C., Guenther, M., Guillian, G., Guimaraes Da Costa, J., Haas, R. M., Haber, C., Hahn, S. R., Hall, C., Handa, T., Handler, R., Hao, W., Happacher, F., Hara, K., Hardman, A. D., Harris, R. M., Hartmann, F., Hatakeyama, K., Hauser, J., Heinrich, J., Heiss, A., Herndon, M., Hill, C., Hoffman, K. D., Holck, C., Hollebeek, R., Holloway, L., Hughes, R., Huston, J., Huth, J., Ikeda, H., Incandela, J., Introzzi, G., Iwai, J., Iwata, Y., James, E., Jones, M., Joshi, U., Kambara, H., Kamon, T., Kaneko, T., Karr, K., Kasha, H., Kato, Y., Keaffaber, T. A., Kelley, K., Kelly, M., Kennedy, R. D., Kephart, R., Khazins, D., Kikuchi, T., Kilminster, B., Kim, B. J., Kim, D. H., Kim, H. S., Kim, M. J., Kim, S. B., Kim, S. H., Kim, Y. K., Kirby, M., Kirk, M., Kirsch, L., Klimenko, S., Koehn, P., Kondo, K., Konigsberg, J., Korn, A., Korytov, A., Kovács, Eve V., Kroll, J., Kruse, M., Kuhlmann, S. E., Kurino, K., Kuwabara, T., Laasanen, A. T., Lai, N., Lami, S., Lammel, S., Lancaster, J., Lancaster, M., Lander, R., Latino, G., LeCompte, T., Lee IV, A. M., Lee, K., Leone, S., Lewis, J. D., Lindgren, M., Liss, T. M., Liu, J. B., Liu, Y. C., Litvintsev, D. O., Lobban, O., Lockyer, N., Loken, J., Loreti, M., Lucchesi, D., Lukens, P., Lusin, S., Lyons, L., Lys, J., Madrak, R., Maeshima, K., Maksimovic, P., Malferrari, L., Mangano, M., Mariotti, M., Martignon, G., Martin, A., Matthews, J. A. J., Mayer, J., Mazzanti, P., McFarland, K. S., McIntyre, P., McKigney, E., Menguzzato, M., Menzione, A., Mesropian, C., Meyer, A., Miao, T., Miller, R., Miller, J. S., Minato, H., Miscetti, S., Mishina, M., Mitselmakher, G., Moggi, N., Moore, E., Moore, R., Morita, Y., Moulik, T., Mulhearn, M., Mukherjee, A., Muller, T., Munar, A., Murat, P., Murgia, S., Nachtman, J., Nagaslaev, V., Nahn, S., Nakada, H., Nakano, I., Nelson, C., Nelson, T., Neu, C., Neuberger, D., Newman-Holmes, C., Ngan, C. -Y P., Niu, H., Nodulman, L., Nomerotski, A., Oh, S. H., Oh, Y. D., Ohmoto, T., Ohsugi, T., Oishi, R., Okusawa, T., Olsen, J., Orejudos, W., Pagliarone, C., Palmonari, F., Paoletti, R., Papadimitriou, Vaia, Partos, D., Patrick, J., Pauletta, G., Paulini, M., Paus, C., Pescara, L., Phillips, T. J., Piacentino, G., Pitts, K. T., Pompos, A., Pondrom, L., Pope, G., Popovic, M., Prokoshin, F., Proudfoot, J., Ptohos, Fotios, Pukhov, O., Punzi, G., Rakitine, A., Reher, D., Reichold, A., Ribon, A., Riegler, W., Rimondi, F., Ristori, L., Riveline, M., Robertson, W. J., Robinson, A., Rodrigo, T., Rolli, S., Rosenson, L., Roser, R., Rossin, R., Roy, A., Ruiz, A., Safonov, A., St. Denis, R., Sakumoto, W. K., Saltzberg, D., Sanchez, C., Sansoni, A., Santi, L., Sato, H., Savard, P., Schlabach, P., Schmidt, E. E., Schmidt, M. P., Schmitt, M., Scodellaro, L., Scott, A., Scribano, A., Segler, S., Seidel, S., Seiya, Y., Semenov, A., Semeria, F., Shah, T., Shapiro, M. D., Shepard, P. F., Shibayama, T., Shimojima, M., Shochet, M., Sidoti, A., Siegrist, J., Sill, A., Sinervo, P., Singh, P., Slaughter, A. J., Sliwa, K., Smith, C., Snider, F. D., Solodsky, A., Spalding, J., Speer, T., Sphicas, Paris A., Spinella, F., Spiropulu, Maria, Spiegel, L., Steele, J., Stefanini, A., Strologas, John, Strumia, F., Stuart, D., Sumorok, K., Suzuki, T., Takano, T., Takashima, R., Takikawa, K., Tamburello, P., Tanaka, M., Tannenbaum, B., Tecchio, M., Tesarek, R., Teng, P. K., Terashi, K., Tether, S., Thompson, A. S., Thurman-Keup, R., Tipton, P., Tkaczyk, S., Toback, D., Tollefson, K., Tollestrup, A., Tonelli, D., Toyoda, H., Trischuk, W., de Trocóniz, J. F., Tseng, J., Turini, N., Ukegawa, F., Vaiciulis, T., Valls, J., Vejcik III, S., Velev, G., Vidal, R., Vila, I., Vilar, R., Volobouev, I., Vucinic, D., Wagner, R. G., Wagner, R. L., Wallace, N. B., Wang, C., Wang, M. J., Ward, B., Waschke, S., Watanabe, T., Waters, D., Watts, T., Webb, R., Wenzel, H., Wester III, W. C., Wicklund, A. B., Wicklund, E., Wilkes, T., Williams, H. H., Wilson, P., Winer, B. L., Winn, D., Wolbers, S., Wolinski, D., Wolinski, J., Wolinski, S., Worm, S., Wu, X., Wyss, J., Yagil, A., Yao, W., Yeh, G. P., Yeh, P., Yoh, J., Yosef, C., Yoshida, T., Yu, I., Yu, S., Yu, Z., Zanetti, A., Zetti, F., Zucchelli, S., Clark, Allan Geoffrey, Kambara, Hisanori, Speer, Thomas, Strumia Michelini, Federica, Wu, Xin, and Ptohos, Fotios [0000-0002-3432-3452]
Subjects: Diffraction, Particle physics, Tevatron, HADRONIC DIFFRACTION, POMERON, General Physics and Astronomy, FOS: Physical sciences, ddc:500.2, Central region, Dissociation (chemistry), High Energy Physics - Experiment, Nuclear physics, Pomeron, Physics and Astronomy (all), High Energy Physics - Experiment (hep-ex), Factorization, Colliding beam accelerators, Quantum number, Double diffraction dissociation, Electron energy levels, Fermilab, High energy physics, Nuclear Experiment, QC, Physics, Pseudorapidity gap, Elementary particles, Monte Carlo methods, Computer simulation, Pseudorapidity, Quantum theory, Hadron, High Energy Physics::Experiment, Protons, Fermilab tevatron collider, Regge theory
Abstract: We present results from a measurement of double diffraction dissociation in $\bar pp$ collisions at the Fermilab Tevatron collider. The production cross section for events with a central pseudorapidity gap of width $\Delta\eta^0>3$ (overlapping $\eta=0$) is found to be $4.43\pm 0.02{(stat)}{\pm 1.18}{(syst) mb}$ [$3.42\pm 0.01{(stat)}{\pm 1.09}{(syst) mb}$] at $\sqrt{s}=1800$ [630] GeV. Our results are compared with previous measurements and with predictions based on Regge theory and factorization., Comment: 10 pages, 4 figures, using RevTeX. Submitted to Physical Review Letters
Published: 2016

43. QCD physics at CDF

Author: Devlin, T., primary
Published: 1996
Full Text: View/download PDF

44. Time for a Time Window Extension: Insights from Late Presenters in the ESCAPE Trial

Author: Evans, J.W., primary, Graham, B.R., additional, Pordeli, P., additional, Al-Ajlan, F.S., additional, Willinsky, R., additional, Montanera, W.J., additional, Rempel, J.L., additional, Shuaib, A., additional, Brennan, P., additional, Williams, D., additional, Roy, D., additional, Poppe, A.Y., additional, Jovin, T.G., additional, Devlin, T., additional, Baxter, B.W., additional, Krings, T., additional, Silver, F.L., additional, Frei, D.F., additional, Fanale, C., additional, Tampieri, D., additional, Teitelbaum, J., additional, Iancu, D., additional, Shankar, J., additional, Barber, P.A., additional, Demchuk, A.M., additional, Goyal, M., additional, Hill, M.D., additional, and Menon, B.K., additional
Published: 2017
Full Text: View/download PDF

45. Removal of Soluble Phosphorus from Surface Water Using Iron (Fe–Fe) and Aluminum (Al–Al) Electrodes

Author: Devlin, T. R., primary, di Biase, A., additional, Wei, V., additional, Elektorowicz, M., additional, and Oleszkiewicz, J. A., additional
Published: 2017
Full Text: View/download PDF

46. Start-Up of an Anaerobic Moving Bed–Biofilm Reactor and Transition to Brewery Wastewater Treatment

Author: di Biase, A., primary, Devlin, T. R., additional, and Oleszkiewicz, J. A., additional
Published: 2016
Full Text: View/download PDF

47. Identifying Image Manipulation Software from Image Features

Author: Boyter, Devlin T.
Subjects: feature extraction, Electrical and Computer Engineering, algorithms
Abstract: As technology steadily increases in the field of image manipulation, determining which software was used to manipulate an image becomes increasingly complex for law enforcement and intelligence agencies. To combat this difficult problem, new techniques that examine the artifacts left behind by a specific manipulation are converted to features for classification. This research implemented four preexisting image manipulation detection techniques into a framework of modules: Two-Dimensional Second Derivative, One-Dimensional Zero Crossings, Quantization Matrices Identification, and File Metadata analysis. The intent is the creation of a framework to develop a capability to determine which specific image manipulation software program manipulated an image. The determination is based on each image manipulation software program having implemented the manipulation algorithms differently. These differences in the implementation will leave behind different artifacts in the resultant image. Experimental results demonstrate the framework's ability to identify from the 48 combinations of image manipulation software programs, scaling, and the algorithm used with a true positive rate of 0.54, false positive rate of 0.01, and a Kappa statistic of 0.53 for Joint Photographic Experts Group (JPEG). The results for Tagged Image File Format (TIFF) images were a true positive rate of 0.53, false positive rate of 0.01, and a Kappa statistic of 0.52.
Published: 2015

48. Effect of atorvastatin in elderly patients with a recent stroke or transient ischemic attack

Author: Chaturvedi, S, Zivin, J, Breazna, A, Amarenco, P, Callahan, A, Goldstein, L, Hennerici, M, Sillesen, H, Rudolph, A, Welch, M, Sparcl, I, Crimmins, D, Davis, S, Dimmitt, S, Donnan, G, Frayne, J, Freilich, D, Zagami, A, Mikocki, J, Schmidauer, C, Schmidt, R, De Bleecker, J, Deceuninck, F, Tack, P, Thijs, V, Gomes Fernandes, J, Beaudry, M, Cote, R, Hoyte, K, Lebrun, L, Mackey, A, Sahlas, D, Selchen, D, Shuaib, A, Spence, J, Teal, P, Winger, M, Matamala, G, Cifkova, R, Kalita, Z, Rektor, I, Rosolova, H, Stipal, R, Vaclavik, D, Boysen, G, Klingenberg, H, Iversen, Hillbom, M, Kaste, M, Numminen, H, Pilke, A, Salmivaara, A, Sivenius, J, Alamowitch, S, Boulliat, J, De Broucker, T, Chollet, F, Mahagne, M, Milandre, L, Moulin, T, Bogdahn, U, Diener, H, Dichgans, M, Glahn, J, Haberl, R, Harms, L, Knecht, S, Kroczek, G, Lichy, C, Sander, D, Schneider, D, Kazis, A, Karageorgiou, C, Milonas, I, Stathis, P, Vogiatzoglou, D, Bornstein, N, Honigman, S, Lampl, Y, Streifler, J, Capurso, A, Comi, G, Ferrarese, C, Gandolfo, C, Poloni, M, Senin, U, Rangel Guerra, R, Boon, A, De Keyser, J, De Kort, P, Haas, J, Kamphuis, D, Koudstaal, P, Anderson, N, Scott, R, Singh, G, Czlonkowska, A, Drozdowski, W, Gralewski, Z, Kozubski, W, Kuczynska Zardzewialy, A, Podemski, R, Stelmasiak, Z, Szczudlik, A, Da Costa Correia, C, Ferro, J, Salgueiro e., C, Lietava, J, Raslova, K, Carr, J, Gardiner, J, Kruger, A, Alvarez Sabin, J, Chamorro, A, Diez Tejedor, E, Fernández, O, Trejo Gabriel y., G, González Marcos, J, Egido Herrero, J, Jiménez Martínez, M, Lago Martin, A, Mostacero Miguel, E, Vivancos Mora, J, Moltó, J, Viguera Romero, J, Cuartero Rodriguez, E, Rodriguez, F, Serena, J, Laska, A, Leijd, B, Strand, T, Terent, A, Waegner, A, Wallén, T, Baumgartner, R, Bogousslavsky, J, Hungerbühler, H, Lyrer, P, Mattle, H, Bath, P, Ekpo, E, Freeman, A, Lees, K, Macleod, M, Macwalter, R, Sharma, A, Shetty, H, Albers, G, Altafullah, I, Benavente, O, Book, D, Broderick, J, Callahan A., 3, Calder, C, Carlini, W, Chippendale, T, Clark, W, Coull, B, Davis, P, Devlin, T, Dick, A, Dooneief, G, Duff, R, Estronza, N, Forteza, A, Frankel, M, Frey, J, Friday, G, Graham, G, Goldstein, J, Hammer, M, Harris, J, Harper, W, Hendin, B, Hendin, D, Hinton, R, Hollander, J, Hughes, R, Kasner, S, Kent, T, Kim, L, Kirshner, H, Lamonte, M, Ledbetter, L, Lee Kwen, P, Levin, K, Libman, R, Matlock, J, Mcdowell, P, McGee F., J, Meyer, B, Minagar, A, Moussouttas, M, Munson, R, Nash, M, Nassief, A, Orr, S, Ratinov, G, Salanga, V, Silliman, S, Singer, R, Smith, D, Sullivan, H, Tietjen, G, Thaler, D, Tuchman, M, Uskavitch, D, Verro, P, Vicari, R, Weinstein, R, Wilterdink, J, Zweifler, R, De Bastos, M, Goldstein, LB, Welch, MA, SPARCL Investigators, Crimmins D, Davis S, Dimmitt S, Donnan G, Frayne J, Freilich D, Zagami A, Mikocki J, Schmidauer C, Schmidt R, De Bleecker J, Deceuninck F, Tack P, Thijs V, Gomes Fernandes J, Beaudry M, Cote R, Hoyte K, Lebrun LH, Mackey A, Sahlas D, Selchen D, Shuaib A, Spence JD, Teal P, Winger M, Matamala G, Cifkova R, Kalita Z, Rektor I, Rosolova H, Stipal R, Vaclavik D, Boysen G, Klingenberg H, Sillesen H, Hillbom M, Kaste M, Numminen H, Pilke A, Salmivaara A, Sivenius J, Alamowitch S, Amarenco P, Boulliat J, De Broucker T, Chollet F, Mahagne MH, Milandre L, Moulin T, Bogdahn U, Diener HC, Dichgans M, Glahn J, Haberl R, Harms L, Hennerici MG, Knecht S, Kroczek G, Lichy C, Sander D, Schneider D, Kazis A, Karageorgiou C, Milonas I, Stathis P, Vogiatzoglou D, Bornstein N, Honigman S, Lampl Y, Streifler J, Capurso A, Comi G, Gandolfo C, Poloni M, Senin U, Rangel Guerra R, Boon AM, De Keyser JH, De Kort PL, Haas JA, Kamphuis DJ, Koudstaal PJ, Anderson N, Scott R, Singh G, Czlonkowska A, Drozdowski W, Gralewski Z, Kozubski W, Kuczynska Zardzewialy A, Podemski R, Stelmasiak Z, Szczudlik A, Da Costa Correia C, Ferro J, Salgueiro e. Cunha L, Lietava J, Raslova K, Carr J, Gardiner J, Kruger A, Alvarez Sabin J, Chamorro A, Diez Tejedor E, Fernández O, Trejo Gabriel y. Galán J, González Marcos J, Egido Herrero J, Jiménez Martínez M, Lago Martin A, Mostacero Miguel E, Vivancos Mora J, Moltó J, Viguera Romero J, Cuartero Rodriguez E, Rodriguez F, Serena J, Laska AC, Leijd B, Strand T, Terent A, Waegner A, Wallén T, Baumgartner R, Bogousslavsky J, Hungerbühler H, Lyrer P, Mattle H, Bath PM, Ekpo EB, Freeman A, Lees KR, MacLeod MJ, MacWalter RS, Sharma AK, Shetty HG, Albers G, Altafullah I, Benavente O, Book D, Broderick J, Callahan A. 3rd, Calder C, Carlini W, Chaturvedi S, Chippendale T, Clark W, Coull B, Davis P, Devlin T, Dick A, Dooneief G, Duff R, Estronza N, Forteza A, Frankel M, Frey J, Friday G, Graham G, Goldstein J, Hammer M, Harris J, Harper W, Hendin B, Hendin D, Hinton R, Hollander J, Hughes R, Kasner S, Kent T, Kim L, Kirshner H, LaMonte M, Ledbetter L, Lee Kwen P, Levin K, Libman R, Matlock J, McDowell P, McGee F. Jr, Meyer B, Minagar A, Moussouttas M, Munson R, Nash M, Nassief A, Orr S, Ratinov G, Salanga V, Silliman S, Singer R, Smith D, Sullivan H, Tietjen G, Thaler D, Tuchman M, Uskavitch D, Verro P, Vicari R, Weinstein R, Wilterdink J, Zweifler R, De Bastos M., FERRARESE, CARLO, Chaturvedi, S, Zivin, J, Breazna, A, Amarenco, P, Callahan, A, Goldstein, L, Hennerici, M, Sillesen, H, Rudolph, A, Welch, M, Sparcl, I, Crimmins, D, Davis, S, Dimmitt, S, Donnan, G, Frayne, J, Freilich, D, Zagami, A, Mikocki, J, Schmidauer, C, Schmidt, R, De Bleecker, J, Deceuninck, F, Tack, P, Thijs, V, Gomes Fernandes, J, Beaudry, M, Cote, R, Hoyte, K, Lebrun, L, Mackey, A, Sahlas, D, Selchen, D, Shuaib, A, Spence, J, Teal, P, Winger, M, Matamala, G, Cifkova, R, Kalita, Z, Rektor, I, Rosolova, H, Stipal, R, Vaclavik, D, Boysen, G, Klingenberg, H, Iversen, Hillbom, M, Kaste, M, Numminen, H, Pilke, A, Salmivaara, A, Sivenius, J, Alamowitch, S, Boulliat, J, De Broucker, T, Chollet, F, Mahagne, M, Milandre, L, Moulin, T, Bogdahn, U, Diener, H, Dichgans, M, Glahn, J, Haberl, R, Harms, L, Knecht, S, Kroczek, G, Lichy, C, Sander, D, Schneider, D, Kazis, A, Karageorgiou, C, Milonas, I, Stathis, P, Vogiatzoglou, D, Bornstein, N, Honigman, S, Lampl, Y, Streifler, J, Capurso, A, Comi, G, Ferrarese, C, Gandolfo, C, Poloni, M, Senin, U, Rangel Guerra, R, Boon, A, De Keyser, J, De Kort, P, Haas, J, Kamphuis, D, Koudstaal, P, Anderson, N, Scott, R, Singh, G, Czlonkowska, A, Drozdowski, W, Gralewski, Z, Kozubski, W, Kuczynska Zardzewialy, A, Podemski, R, Stelmasiak, Z, Szczudlik, A, Da Costa Correia, C, Ferro, J, Salgueiro e., C, Lietava, J, Raslova, K, Carr, J, Gardiner, J, Kruger, A, Alvarez Sabin, J, Chamorro, A, Diez Tejedor, E, Fernández, O, Trejo Gabriel y., G, González Marcos, J, Egido Herrero, J, Jiménez Martínez, M, Lago Martin, A, Mostacero Miguel, E, Vivancos Mora, J, Moltó, J, Viguera Romero, J, Cuartero Rodriguez, E, Rodriguez, F, Serena, J, Laska, A, Leijd, B, Strand, T, Terent, A, Waegner, A, Wallén, T, Baumgartner, R, Bogousslavsky, J, Hungerbühler, H, Lyrer, P, Mattle, H, Bath, P, Ekpo, E, Freeman, A, Lees, K, Macleod, M, Macwalter, R, Sharma, A, Shetty, H, Albers, G, Altafullah, I, Benavente, O, Book, D, Broderick, J, Callahan A., 3, Calder, C, Carlini, W, Chippendale, T, Clark, W, Coull, B, Davis, P, Devlin, T, Dick, A, Dooneief, G, Duff, R, Estronza, N, Forteza, A, Frankel, M, Frey, J, Friday, G, Graham, G, Goldstein, J, Hammer, M, Harris, J, Harper, W, Hendin, B, Hendin, D, Hinton, R, Hollander, J, Hughes, R, Kasner, S, Kent, T, Kim, L, Kirshner, H, Lamonte, M, Ledbetter, L, Lee Kwen, P, Levin, K, Libman, R, Matlock, J, Mcdowell, P, McGee F., J, Meyer, B, Minagar, A, Moussouttas, M, Munson, R, Nash, M, Nassief, A, Orr, S, Ratinov, G, Salanga, V, Silliman, S, Singer, R, Smith, D, Sullivan, H, Tietjen, G, Thaler, D, Tuchman, M, Uskavitch, D, Verro, P, Vicari, R, Weinstein, R, Wilterdink, J, Zweifler, R, De Bastos, M, Goldstein, LB, Welch, MA, SPARCL Investigators, Crimmins D, Davis S, Dimmitt S, Donnan G, Frayne J, Freilich D, Zagami A, Mikocki J, Schmidauer C, Schmidt R, De Bleecker J, Deceuninck F, Tack P, Thijs V, Gomes Fernandes J, Beaudry M, Cote R, Hoyte K, Lebrun LH, Mackey A, Sahlas D, Selchen D, Shuaib A, Spence JD, Teal P, Winger M, Matamala G, Cifkova R, Kalita Z, Rektor I, Rosolova H, Stipal R, Vaclavik D, Boysen G, Klingenberg H, Sillesen H, Hillbom M, Kaste M, Numminen H, Pilke A, Salmivaara A, Sivenius J, Alamowitch S, Amarenco P, Boulliat J, De Broucker T, Chollet F, Mahagne MH, Milandre L, Moulin T, Bogdahn U, Diener HC, Dichgans M, Glahn J, Haberl R, Harms L, Hennerici MG, Knecht S, Kroczek G, Lichy C, Sander D, Schneider D, Kazis A, Karageorgiou C, Milonas I, Stathis P, Vogiatzoglou D, Bornstein N, Honigman S, Lampl Y, Streifler J, Capurso A, Comi G, Gandolfo C, Poloni M, Senin U, Rangel Guerra R, Boon AM, De Keyser JH, De Kort PL, Haas JA, Kamphuis DJ, Koudstaal PJ, Anderson N, Scott R, Singh G, Czlonkowska A, Drozdowski W, Gralewski Z, Kozubski W, Kuczynska Zardzewialy A, Podemski R, Stelmasiak Z, Szczudlik A, Da Costa Correia C, Ferro J, Salgueiro e. Cunha L, Lietava J, Raslova K, Carr J, Gardiner J, Kruger A, Alvarez Sabin J, Chamorro A, Diez Tejedor E, Fernández O, Trejo Gabriel y. Galán J, González Marcos J, Egido Herrero J, Jiménez Martínez M, Lago Martin A, Mostacero Miguel E, Vivancos Mora J, Moltó J, Viguera Romero J, Cuartero Rodriguez E, Rodriguez F, Serena J, Laska AC, Leijd B, Strand T, Terent A, Waegner A, Wallén T, Baumgartner R, Bogousslavsky J, Hungerbühler H, Lyrer P, Mattle H, Bath PM, Ekpo EB, Freeman A, Lees KR, MacLeod MJ, MacWalter RS, Sharma AK, Shetty HG, Albers G, Altafullah I, Benavente O, Book D, Broderick J, Callahan A. 3rd, Calder C, Carlini W, Chaturvedi S, Chippendale T, Clark W, Coull B, Davis P, Devlin T, Dick A, Dooneief G, Duff R, Estronza N, Forteza A, Frankel M, Frey J, Friday G, Graham G, Goldstein J, Hammer M, Harris J, Harper W, Hendin B, Hendin D, Hinton R, Hollander J, Hughes R, Kasner S, Kent T, Kim L, Kirshner H, LaMonte M, Ledbetter L, Lee Kwen P, Levin K, Libman R, Matlock J, McDowell P, McGee F. Jr, Meyer B, Minagar A, Moussouttas M, Munson R, Nash M, Nassief A, Orr S, Ratinov G, Salanga V, Silliman S, Singer R, Smith D, Sullivan H, Tietjen G, Thaler D, Tuchman M, Uskavitch D, Verro P, Vicari R, Weinstein R, Wilterdink J, Zweifler R, De Bastos M., and FERRARESE, CARLO
Abstract: BACKGROUND: It is unclear whether patients age 65 years and over with a recent stroke or TIA benefit from statin treatment to a similar degree as younger patients. METHODS: The 4,731 patient cohort in the SPARCL study was divided into an elderly group (65 and over) and a younger group. The primary endpoint (fatal or nonfatal stroke) and secondary endpoints were analyzed, with calculation of the hazard ratio (HR) and p values from a Cox regression model. RESULTS: There were 2,249 patients in the elderly group and 2,482 in the younger group. The baseline LDL (133 mg/dL) and total cholesterol were comparable in the two groups. The elderly and younger groups had a 61.4 mg/dL and 58.7 mg/dL decrease in mean LDL during the trial. The primary endpoint was reduced by 26% in younger patients (HR 0.74, 0.57-0.96, p = 0.02) and by 10% in elderly subjects (HR 0.90, 0.73-1.11, p = 0.33). A test of heterogeneity for a treatment-age interaction was not significant (p = 0.52). The risk of stroke or TIA (HR 0.79, p = 0.01), major coronary events (HR 0.68, p = 0.035), any coronary heart disease event (HR 0.61, p = 0.0006), and revascularization procedures (HR 0.55, p = 0.0005) was reduced in the elderly group. CONCLUSIONS: There was no heterogeneity in the stroke reduction seen with atorvastatin in the elderly and younger groups. Cardiac events and revascularization procedures were also lower in both the elderly and younger subgroups treated with atorvastatin. These results support the use of atorvastatin in elderly patients with recent stroke or TIA.
Published: 2009

49. Relative effects of statin therapy on stroke and cardiovascular events in men and women: Secondary analysis of the stroke prevention by aggressive reduction in cholesterol levels (SPARCL) study

Author: Goldstein, L, Amarenco, P, Lamonte, M, Gilbert, S, Messig, M, Callahan, A, Hennerici, M, Sillesen, H, Welch, K, Sparcl, I, Bogousslavsky, J, Zivin, J, Clark, W, Dávalos, A, Kaste, M, Leiter, L, Altafullah, I, Graham, G, Glahn, J, Jiménez Hernández, D, Macwalter, R, Scott, R, Shuaib, A, Sivenius, J, Stipal, R, Hart, R, Marsh, J, Norrving, B, Pocock, S, Sacco, R, Easton, J, Brown, M, Nagy, Z, Whisnant, J, O'Neill, B, Kleber, F, Lablanche, J, Welty, F, Crimmins, D, Davis, S, Dimmitt, S, Donnan, G, Frayne, J, Freilich, D, Zagami, A, Mikocki, J, Schmidauer, C, Schmidt, R, De Bleecker, J, Deceuninck, F, Tack, P, Thijs, V, Gomes Fernandes, J, Beaudry, M, Cote, R, Hoyte, K, Lebrun, L, Mackey, A, Sahlas, D, Selchen, D, Spence, J, Teal, P, Winger, M, Matamala, G, Cifkova, R, Kalita, Z, Rektor, I, Rosolova, H, Vaclavik, D, Boysen, G, Klingenberg, H, Hillbom, M, Numminen, H, Pilke, A, Salmivaara, A, Alamowitch, S, Boulliat, J, De Broucker, T, Chollet, F, Mahagne, M, Milandre, L, Moulin, T, Milonas, I, Stathis, P, Vogiatzoglou, D, Bornstein, N, Honigman, S, Lampl, Y, Streifler, J, Capurso, A, Comi, G, Ferrarese, C, Gandolfo, C, Poloni, M, Senin, U, Rangel Guerra, R, Boon, A, De Keyser, J, De Kort, P, Haas, J, Kamphuis, D, Koudstaal, P, Anderson, N, Singh, G, Czlonkowska, A, Drozdowski, W, Gralewski, Z, Kozubski, W, Kuczynska Zardzewialy, A, Podemski, R, Stelmasiak, Z, Szczudlik, A, Da Costa Correia, C, Ferro, J, Salgueiro e., C, Lietava, J, Raslova, K, Carr, J, Gardiner, J, Kruger, A, Alvarez Sabin, J, Chamorro, A, Diez Tejedor, E, Fernández, O, Trejo Gabriel y., G, González Marcos, J, Egido Herrero, J, Jiménez Martínez, M, Lago Martin, A, Mostacero Miguel, E, Vivancos Mora, J, Moltó, J, Viguera Romero, J, Cuartero Rodriguez, E, Rubio, F, Serena, J, Laska, A, Leijd, B, Strand, T, Terent, A, Waegner, A, Wallén, T, Baumgartner, R, Hungerbühler, H, Lyrer, P, Mattle, H, Bath, P, Ekpo, E, Freeman, A, Lees, K, Macleod, M, Sharma, A, Shetty, H, Albers, G, Benavente, O, Book, D, Broderick, J, Calder, C, Carlini, W, Chaturvedi, S, Chippendale, T, Coull, B, Davis, P, Devlin, T, Dick, A, Dooneief, G, Duff, R, Estronza, N, Forteza, A, Frankel, M, Frey, J, Friday, G, Goldstein, J, Hammer, M, Harris, J, Harper, W, Hendin, B, Hess, D, Hinton, R, Hollander, J, Hughes, R, Kasner, S, Kent, T, Kim, L, Kirshner, H, Ledbetter, L, Lee Kwen, P, Levin, K, Libman, R, Matlock, J, Mcdowell, P, McGee F., J, Meyer, B, Minagar, A, Moussouttas, M, Munson, R, Nash, M, Nassief, A, Orr, S, Ratinov, G, Salanga, V, Silliman, S, Singer, R, Smith, D, Sullivan, H, Tietjen, G, Thaler, D, Tuchman, M, Uskavitch, D, Verro, P, Vicari, R, Weinstein, R, Wilterdink, J, Zweifler, R, De Bastos, M, Goldstein, LB, Welch, KMA, SPARCL investigators, Bogousslavsky J, Goldstein LB, Zivin J, Clark W, Dávalos A, Kaste M, Leiter L, Altafullah I, Graham G, Glahn J, Jiménez Hernández D, MacWalter R, Scott R, Shuaib A, Sivenius J, Stipal R, Hart R, Marsh J, Norrving B, Pocock S, Sacco R, Easton J, Brown M, Nagy Z, Whisnant J, O'Neill B, Kleber F, LaBlanche JM, Welty F, Crimmins D, Davis S, Dimmitt S, Donnan G, Frayne J, Freilich D, Zagami A, Mikocki J, Schmidauer C, Schmidt R, De Bleecker J, Deceuninck F, Tack P, Thijs V, Gomes Fernandes J, Beaudry M, Cote R, Hoyte K, Lebrun LH, Mackey A, Sahlas D, Selchen D, Spence JD, Teal P, Winger M, Matamala G, Cifkova R, Kalita Z, Rektor I, Rosolova H, Vaclavik D, Boysen G, Klingenberg H, Sillesen H, Hillbom M, Numminen H, Pilke A, Salmivaara A, Alamowitch S, Amarenco P, Boulliat J, De Broucker T, Chollet F, Mahagne MH, Milandre L, Moulin T, Milonas I, Stathis P, Vogiatzoglou D, Bornstein N, Honigman S, Lampl Y, Streifler J, Capurso A, Comi G, Gandolfo C, Poloni M, Senin U, Rangel Guerra R, Boon AM, De Keyser JH, De Kort PL, Haas JA, Kamphuis DJ, Koudstaal PJ, Anderson N, Singh G, Czlonkowska A, Drozdowski W, Gralewski Z, Kozubski W, Kuczynska Zardzewialy A, Podemski R, Stelmasiak Z, Szczudlik A, Da Costa Correia C, Ferro J, Salgueiro e. Cunha L, Lietava J, Raslova K, Carr J, Gardiner J, Kruger A, Alvarez Sabin J, Chamorro A, Diez Tejedor E, Fernández O, Trejo Gabriel y. Galán J, González Marcos J, Egido Herrero J, Jiménez Martínez M, Lago Martin A, Mostacero Miguel E, Vivancos Mora J, Moltó J, Viguera Romero J, Cuartero Rodriguez E, Rubio F, Serena J, Laska AC, Leijd B, Strand T, Terent A, Waegner A, Wallén T, Baumgartner R, Hungerbühler H, Lyrer P, Mattle H, Bath PM, Ekpo EB, Freeman A, Lees KR, MacLeod MJ, MacWalter RS, Sharma AK, Shetty HG, Albers G, Benavente O, Book D, Broderick J, Calder C, Carlini W, Chaturvedi S, Chippendale T, Coull B, Davis P, Devlin T, Dick A, Dooneief G, Duff R, Estronza N, Forteza A, Frankel M, Frey J, Friday G, Goldstein J, Hammer M, Harris J, Harper W, Hendin B, Hess D, Hinton R, Hollander J, Hughes R, Kasner S, Kent T, Kim L, Kirshner H, LaMonte M, Ledbetter L, Lee Kwen P, Levin K, Libman R, Matlock J, McDowell P, McGee F. Jr, Meyer B, Minagar A, Moussouttas M, Munson R, Nash M, Nassief A, Orr S, Ratinov G, Salanga V, Silliman S, Singer R, Smith D, Sullivan H, Tietjen G, Thaler D, Tuchman M, Uskavitch D, Verro P, Vicari R, Weinstein R, Wilterdink J, Zweifler R, De Bastos M., FERRARESE, CARLO, Goldstein, L, Amarenco, P, Lamonte, M, Gilbert, S, Messig, M, Callahan, A, Hennerici, M, Sillesen, H, Welch, K, Sparcl, I, Bogousslavsky, J, Zivin, J, Clark, W, Dávalos, A, Kaste, M, Leiter, L, Altafullah, I, Graham, G, Glahn, J, Jiménez Hernández, D, Macwalter, R, Scott, R, Shuaib, A, Sivenius, J, Stipal, R, Hart, R, Marsh, J, Norrving, B, Pocock, S, Sacco, R, Easton, J, Brown, M, Nagy, Z, Whisnant, J, O'Neill, B, Kleber, F, Lablanche, J, Welty, F, Crimmins, D, Davis, S, Dimmitt, S, Donnan, G, Frayne, J, Freilich, D, Zagami, A, Mikocki, J, Schmidauer, C, Schmidt, R, De Bleecker, J, Deceuninck, F, Tack, P, Thijs, V, Gomes Fernandes, J, Beaudry, M, Cote, R, Hoyte, K, Lebrun, L, Mackey, A, Sahlas, D, Selchen, D, Spence, J, Teal, P, Winger, M, Matamala, G, Cifkova, R, Kalita, Z, Rektor, I, Rosolova, H, Vaclavik, D, Boysen, G, Klingenberg, H, Hillbom, M, Numminen, H, Pilke, A, Salmivaara, A, Alamowitch, S, Boulliat, J, De Broucker, T, Chollet, F, Mahagne, M, Milandre, L, Moulin, T, Milonas, I, Stathis, P, Vogiatzoglou, D, Bornstein, N, Honigman, S, Lampl, Y, Streifler, J, Capurso, A, Comi, G, Ferrarese, C, Gandolfo, C, Poloni, M, Senin, U, Rangel Guerra, R, Boon, A, De Keyser, J, De Kort, P, Haas, J, Kamphuis, D, Koudstaal, P, Anderson, N, Singh, G, Czlonkowska, A, Drozdowski, W, Gralewski, Z, Kozubski, W, Kuczynska Zardzewialy, A, Podemski, R, Stelmasiak, Z, Szczudlik, A, Da Costa Correia, C, Ferro, J, Salgueiro e., C, Lietava, J, Raslova, K, Carr, J, Gardiner, J, Kruger, A, Alvarez Sabin, J, Chamorro, A, Diez Tejedor, E, Fernández, O, Trejo Gabriel y., G, González Marcos, J, Egido Herrero, J, Jiménez Martínez, M, Lago Martin, A, Mostacero Miguel, E, Vivancos Mora, J, Moltó, J, Viguera Romero, J, Cuartero Rodriguez, E, Rubio, F, Serena, J, Laska, A, Leijd, B, Strand, T, Terent, A, Waegner, A, Wallén, T, Baumgartner, R, Hungerbühler, H, Lyrer, P, Mattle, H, Bath, P, Ekpo, E, Freeman, A, Lees, K, Macleod, M, Sharma, A, Shetty, H, Albers, G, Benavente, O, Book, D, Broderick, J, Calder, C, Carlini, W, Chaturvedi, S, Chippendale, T, Coull, B, Davis, P, Devlin, T, Dick, A, Dooneief, G, Duff, R, Estronza, N, Forteza, A, Frankel, M, Frey, J, Friday, G, Goldstein, J, Hammer, M, Harris, J, Harper, W, Hendin, B, Hess, D, Hinton, R, Hollander, J, Hughes, R, Kasner, S, Kent, T, Kim, L, Kirshner, H, Ledbetter, L, Lee Kwen, P, Levin, K, Libman, R, Matlock, J, Mcdowell, P, McGee F., J, Meyer, B, Minagar, A, Moussouttas, M, Munson, R, Nash, M, Nassief, A, Orr, S, Ratinov, G, Salanga, V, Silliman, S, Singer, R, Smith, D, Sullivan, H, Tietjen, G, Thaler, D, Tuchman, M, Uskavitch, D, Verro, P, Vicari, R, Weinstein, R, Wilterdink, J, Zweifler, R, De Bastos, M, Goldstein, LB, Welch, KMA, SPARCL investigators, Bogousslavsky J, Goldstein LB, Zivin J, Clark W, Dávalos A, Kaste M, Leiter L, Altafullah I, Graham G, Glahn J, Jiménez Hernández D, MacWalter R, Scott R, Shuaib A, Sivenius J, Stipal R, Hart R, Marsh J, Norrving B, Pocock S, Sacco R, Easton J, Brown M, Nagy Z, Whisnant J, O'Neill B, Kleber F, LaBlanche JM, Welty F, Crimmins D, Davis S, Dimmitt S, Donnan G, Frayne J, Freilich D, Zagami A, Mikocki J, Schmidauer C, Schmidt R, De Bleecker J, Deceuninck F, Tack P, Thijs V, Gomes Fernandes J, Beaudry M, Cote R, Hoyte K, Lebrun LH, Mackey A, Sahlas D, Selchen D, Spence JD, Teal P, Winger M, Matamala G, Cifkova R, Kalita Z, Rektor I, Rosolova H, Vaclavik D, Boysen G, Klingenberg H, Sillesen H, Hillbom M, Numminen H, Pilke A, Salmivaara A, Alamowitch S, Amarenco P, Boulliat J, De Broucker T, Chollet F, Mahagne MH, Milandre L, Moulin T, Milonas I, Stathis P, Vogiatzoglou D, Bornstein N, Honigman S, Lampl Y, Streifler J, Capurso A, Comi G, Gandolfo C, Poloni M, Senin U, Rangel Guerra R, Boon AM, De Keyser JH, De Kort PL, Haas JA, Kamphuis DJ, Koudstaal PJ, Anderson N, Singh G, Czlonkowska A, Drozdowski W, Gralewski Z, Kozubski W, Kuczynska Zardzewialy A, Podemski R, Stelmasiak Z, Szczudlik A, Da Costa Correia C, Ferro J, Salgueiro e. Cunha L, Lietava J, Raslova K, Carr J, Gardiner J, Kruger A, Alvarez Sabin J, Chamorro A, Diez Tejedor E, Fernández O, Trejo Gabriel y. Galán J, González Marcos J, Egido Herrero J, Jiménez Martínez M, Lago Martin A, Mostacero Miguel E, Vivancos Mora J, Moltó J, Viguera Romero J, Cuartero Rodriguez E, Rubio F, Serena J, Laska AC, Leijd B, Strand T, Terent A, Waegner A, Wallén T, Baumgartner R, Hungerbühler H, Lyrer P, Mattle H, Bath PM, Ekpo EB, Freeman A, Lees KR, MacLeod MJ, MacWalter RS, Sharma AK, Shetty HG, Albers G, Benavente O, Book D, Broderick J, Calder C, Carlini W, Chaturvedi S, Chippendale T, Coull B, Davis P, Devlin T, Dick A, Dooneief G, Duff R, Estronza N, Forteza A, Frankel M, Frey J, Friday G, Goldstein J, Hammer M, Harris J, Harper W, Hendin B, Hess D, Hinton R, Hollander J, Hughes R, Kasner S, Kent T, Kim L, Kirshner H, LaMonte M, Ledbetter L, Lee Kwen P, Levin K, Libman R, Matlock J, McDowell P, McGee F. Jr, Meyer B, Minagar A, Moussouttas M, Munson R, Nash M, Nassief A, Orr S, Ratinov G, Salanga V, Silliman S, Singer R, Smith D, Sullivan H, Tietjen G, Thaler D, Tuchman M, Uskavitch D, Verro P, Vicari R, Weinstein R, Wilterdink J, Zweifler R, De Bastos M., and FERRARESE, CARLO
Abstract: BACKGROUND AND PURPOSE: In SPARCL, treatment with atorvastatin 80 mg daily reduced stroke risk in patients with recent stroke or TIA and no known coronary heart disease by 16% versus placebo over 4.9 years of follow-up. The purpose of this secondary analysis was to determine whether men and women similarly benefited from randomization to statin treatment. METHODS: The effect of sex on treatment-related reductions in stroke and other cardiovascular outcomes were analyzed with Cox regression modeling testing for sex by treatment interactions. RESULTS: Women (n=1908) constituted 40% of the SPARCL study population. At baseline, men (n=2823) were younger (62.0+/-0.21 versus 63.9+/-0.27 years), had lower systolic BPs (138.1+/-0.35 versus 139.5+/-0.47 mm Hg), higher diastolic BPs (82.2+/-0.20 versus 81.0+/-0.25 mm Hg), more frequently had a history of smoking (73% versus 38%), and had lower total cholesterol (207.0+/-0.54 versus 218.9+/-0.67 mg/dL) and LDL-C levels (132+/-0.45 versus 134+/-0.57 mg/dL) than women. Use of antithrombotics and antihypertensives were similar. After prespecified adjustment for region, entry event, time since event, and age, there were no sex by treatment interactions for the combined risk of nonfatal and fatal stroke (treatment Hazard Ratio, HR=0.84, 95% CI 0.68, 1.02 in men versus HR=0.84, 95% CI 0.63, 1.11 in women; treatment x sex interaction P=0.99), major cardiac events (HR=0.61, 95% CI 0.42, 0.87 in men versus HR=0.76, 95% CI 0.48, 1.21 in women; P=0.45), major cardiovascular events (HR=0.78, 95% CI 0.65, 0.93 in men versus HR=0.84, 95% CI 0.65, 1.07 in women; P=0.63), revascularization procedures (HR=0.50, 95% CI 0.37, 0.67 in men versus HR=0.76, 95% CI 0.46, 1.24 in women; P=0.17), or any CHD event (HR=0.54, 95% CI 0.41, 0.72 in men versus 0.67 95% CI 0.46, 0.98 in women; P=0.40). CONCLUSIONS: Stroke and other cardiovascular events are similarly reduced with atorvastatin 80 mg/d in men and women with recent stroke or TIA.
Published: 2008

50. Relative effects of statin therapy on stroke and cardiovascular events in men and women: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study

Author: Goldstein, LB, Amarenco, P, Lamonte, M, Gilbert, S, Messig, M, Callahan, A, Hennerici, M, Sillesen, H, Welch, KMA, SPARCL investigators, Bogousslavsky J, Goldstein LB, Zivin J, Clark W, Dávalos A, Kaste M, Leiter L, Altafullah I, Graham G, Glahn J, Jiménez Hernández D, MacWalter R, Scott R, Shuaib A, Sivenius J, Stipal R, Hart R, Marsh J, Norrving B, Pocock S, Sacco R, Easton J, Brown M, Nagy Z, Whisnant J, O'Neill B, Kleber F, LaBlanche JM, Welty F, Crimmins D, Davis S, Dimmitt S, Donnan G, Frayne J, Freilich D, Zagami A, Mikocki J, Schmidauer C, Schmidt R, De Bleecker J, Deceuninck F, Tack P, Thijs V, Gomes Fernandes J, Beaudry M, Cote R, Hoyte K, Lebrun LH, Mackey A, Sahlas D, Selchen D, Spence JD, Teal P, Winger M, Matamala G, Cifkova R, Kalita Z, Rektor I, Rosolova H, Vaclavik D, Boysen G, Klingenberg H, Sillesen H, Hillbom M, Numminen H, Pilke A, Salmivaara A, Alamowitch S, Amarenco P, Boulliat J, De Broucker T, Chollet F, Mahagne MH, Milandre L, Moulin T, Milonas I, Stathis P, Vogiatzoglou D, Bornstein N, Honigman S, Lampl Y, Streifler J, Capurso A, Comi G, Gandolfo C, Poloni M, Senin U, Rangel Guerra R, Boon AM, De Keyser JH, De Kort PL, Haas JA, Kamphuis DJ, Koudstaal PJ, Anderson N, Singh G, Czlonkowska A, Drozdowski W, Gralewski Z, Kozubski W, Kuczynska Zardzewialy A, Podemski R, Stelmasiak Z, Szczudlik A, Da Costa Correia C, Ferro J, Salgueiro e. Cunha L, Lietava J, Raslova K, Carr J, Gardiner J, Kruger A, Alvarez Sabin J, Chamorro A, Diez Tejedor E, Fernández O, Trejo Gabriel y. Galán J, González Marcos J, Egido Herrero J, Jiménez Martínez M, Lago Martin A, Mostacero Miguel E, Vivancos Mora J, Moltó J, Viguera Romero J, Cuartero Rodriguez E, Rubio F, Serena J, Laska AC, Leijd B, Strand T, Terent A, Waegner A, Wallén T, Baumgartner R, Hungerbühler H, Lyrer P, Mattle H, Bath PM, Ekpo EB, Freeman A, Lees KR, MacLeod MJ, MacWalter RS, Sharma AK, Shetty HG, Albers G, Benavente O, Book D, Broderick J, Calder C, Carlini W, Chaturvedi S, Chippendale T, Coull B, Davis P, Devlin T, Dick A, Dooneief G, Duff R, Estronza N, Forteza A, Frankel M, Frey J, Friday G, Goldstein J, Hammer M, Harris J, Harper W, Hendin B, Hess D, Hinton R, Hollander J, Hughes R, Kasner S, Kent T, Kim L, Kirshner H, LaMonte M, Ledbetter L, Lee Kwen P, Levin K, Libman R, Matlock J, McDowell P, McGee F. Jr, Meyer B, Minagar A, Moussouttas M, Munson R, Nash M, Nassief A, Orr S, Ratinov G, Salanga V, Silliman S, Singer R, Smith D, Sullivan H, Tietjen G, Thaler D, Tuchman M, Uskavitch D, Verro P, Vicari R, Weinstein R, Wilterdink J, Zweifler R, De Bastos M., FERRARESE, CARLO, Goldstein, L, Amarenco, P, Lamonte, M, Gilbert, S, Messig, M, Callahan, A, Hennerici, M, Sillesen, H, Welch, K, Sparcl, I, Bogousslavsky, J, Zivin, J, Clark, W, Dávalos, A, Kaste, M, Leiter, L, Altafullah, I, Graham, G, Glahn, J, Jiménez Hernández, D, Macwalter, R, Scott, R, Shuaib, A, Sivenius, J, Stipal, R, Hart, R, Marsh, J, Norrving, B, Pocock, S, Sacco, R, Easton, J, Brown, M, Nagy, Z, Whisnant, J, O'Neill, B, Kleber, F, Lablanche, J, Welty, F, Crimmins, D, Davis, S, Dimmitt, S, Donnan, G, Frayne, J, Freilich, D, Zagami, A, Mikocki, J, Schmidauer, C, Schmidt, R, De Bleecker, J, Deceuninck, F, Tack, P, Thijs, V, Gomes Fernandes, J, Beaudry, M, Cote, R, Hoyte, K, Lebrun, L, Mackey, A, Sahlas, D, Selchen, D, Spence, J, Teal, P, Winger, M, Matamala, G, Cifkova, R, Kalita, Z, Rektor, I, Rosolova, H, Vaclavik, D, Boysen, G, Klingenberg, H, Hillbom, M, Numminen, H, Pilke, A, Salmivaara, A, Alamowitch, S, Boulliat, J, De Broucker, T, Chollet, F, Mahagne, M, Milandre, L, Moulin, T, Milonas, I, Stathis, P, Vogiatzoglou, D, Bornstein, N, Honigman, S, Lampl, Y, Streifler, J, Capurso, A, Comi, G, Ferrarese, C, Gandolfo, C, Poloni, M, Senin, U, Rangel Guerra, R, Boon, A, De Keyser, J, De Kort, P, Haas, J, Kamphuis, D, Koudstaal, P, Anderson, N, Singh, G, Czlonkowska, A, Drozdowski, W, Gralewski, Z, Kozubski, W, Kuczynska Zardzewialy, A, Podemski, R, Stelmasiak, Z, Szczudlik, A, Da Costa Correia, C, Ferro, J, Salgueiro e., C, Lietava, J, Raslova, K, Carr, J, Gardiner, J, Kruger, A, Alvarez Sabin, J, Chamorro, A, Diez Tejedor, E, Fernández, O, Trejo Gabriel y., G, González Marcos, J, Egido Herrero, J, Jiménez Martínez, M, Lago Martin, A, Mostacero Miguel, E, Vivancos Mora, J, Moltó, J, Viguera Romero, J, Cuartero Rodriguez, E, Rubio, F, Serena, J, Laska, A, Leijd, B, Strand, T, Terent, A, Waegner, A, Wallén, T, Baumgartner, R, Hungerbühler, H, Lyrer, P, Mattle, H, Bath, P, Ekpo, E, Freeman, A, Lees, K, Macleod, M, Sharma, A, Shetty, H, Albers, G, Benavente, O, Book, D, Broderick, J, Calder, C, Carlini, W, Chaturvedi, S, Chippendale, T, Coull, B, Davis, P, Devlin, T, Dick, A, Dooneief, G, Duff, R, Estronza, N, Forteza, A, Frankel, M, Frey, J, Friday, G, Goldstein, J, Hammer, M, Harris, J, Harper, W, Hendin, B, Hess, D, Hinton, R, Hollander, J, Hughes, R, Kasner, S, Kent, T, Kim, L, Kirshner, H, Ledbetter, L, Lee Kwen, P, Levin, K, Libman, R, Matlock, J, Mcdowell, P, McGee F., J, Meyer, B, Minagar, A, Moussouttas, M, Munson, R, Nash, M, Nassief, A, Orr, S, Ratinov, G, Salanga, V, Silliman, S, Singer, R, Smith, D, Sullivan, H, Tietjen, G, Thaler, D, Tuchman, M, Uskavitch, D, Verro, P, Vicari, R, Weinstein, R, Wilterdink, J, Zweifler, R, and De Bastos, M
Subjects: Male, Atorvastatin, Blood Pressure, Sex Factor, Pyrrole, Triglyceride, law.invention, Randomized controlled trial, law, Stroke, Sex Characteristics, Middle Aged, Heptanoic Acid, Cholesterol, Treatment Outcome, Data Interpretation, Statistical, Hypertension, Population study, Female, Cardiology and Cardiovascular Medicine, Human, medicine.drug, medicine.medical_specialty, Randomization, Logistic Model, Reproducibility of Result, Placebo, Sex Factors, Internal medicine, medicine, Humans, Pyrroles, Triglycerides, Advanced and Specialized Nursing, Apolipoprotein A-I, Proportional hazards model, business.industry, Reproducibility of Results, Sex Characteristic, medicine.disease, Surgery, Blood pressure, Logistic Models, Heptanoic Acids, Hydroxymethylglutaryl-CoA Reductase Inhibitor, Neurology (clinical), Hydroxymethylglutaryl-CoA Reductase Inhibitors, business
Abstract: Background and Purpose— In SPARCL, treatment with atorvastatin 80 mg daily reduced stroke risk in patients with recent stroke or TIA and no known coronary heart disease by 16% versus placebo over 4.9 years of follow-up. The purpose of this secondary analysis was to determine whether men and women similarly benefited from randomization to statin treatment. Methods— The effect of sex on treatment-related reductions in stroke and other cardiovascular outcomes were analyzed with Cox regression modeling testing for sex by treatment interactions. Results— Women (n=1908) constituted 40% of the SPARCL study population. At baseline, men (n=2823) were younger (62.0±0.21versus 63.9±0.27 years), had lower systolic BPs (138.1±0.35 versus 139.5±0.47 mm Hg), higher diastolic BPs (82.2±0.20 versus 81.0±0.25 mm Hg), more frequently had a history of smoking (73% versus 38%), and had lower total cholesterol (207.0±0.54 versus 218.9±0.67 mg/dL) and LDL-C levels (132±0.45 versus 134±0.57 mg/dL) than women. Use of antithrombotics and antihypertensives were similar. After prespecified adjustment for region, entry event, time since event, and age, there were no sex by treatment interactions for the combined risk of nonfatal and fatal stroke (treatment Hazard Ratio, HR=0.84, 95% CI 0.68, 1.02 in men versus HR=0.84, 95% CI 0.63, 1.11 in women; treatment×sex interaction P =0.99), major cardiac events (HR=0.61, 95% CI 0.42, 0.87 in men versus HR=0.76, 95% CI 0.48, 1.21 in women; P =0.45), major cardiovascular events (HR=0.78, 95% CI 0.65, 0.93 in men versus HR=0.84, 95% CI 0.65, 1.07 in women; P =0.63), revascularization procedures (HR=0.50, 95% CI 0.37, 0.67 in men versus HR=0.76, 95% CI 0.46, 1.24 in women; P =0.17), or any CHD event (HR=0.54, 95% CI 0.41, 0.72 in men versus 0.67 95% CI 0.46, 0.98 in women; P =0.40). Conclusion— Stroke and other cardiovascular events are similarly reduced with atorvastatin 80 mg/d in men and women with recent stroke or TIA.
Published: 2008

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