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Relative effects of statin therapy on stroke and cardiovascular events in men and women: Secondary analysis of the stroke prevention by aggressive reduction in cholesterol levels (SPARCL) study
Authors :
Goldstein, L Amarenco, P Lamonte, M Gilbert, S Messig, M Callahan, A Hennerici, M Sillesen, H Welch, K Sparcl, I Bogousslavsky, J Zivin, J Clark, W Dávalos, A Kaste, M Leiter, L Altafullah, I Graham, G Glahn, J Jiménez Hernández, D Macwalter, R Scott, R Shuaib, A Sivenius, J Stipal, R Hart, R Marsh, J Norrving, B Pocock, S Sacco, R Easton, J Brown, M Nagy, Z Whisnant, J O'Neill, B Kleber, F Lablanche, J Welty, F Crimmins, D Davis, S Dimmitt, S Donnan, G Frayne, J Freilich, D Zagami, A Mikocki, J Schmidauer, C Schmidt, R De Bleecker, J Deceuninck, F Tack, P Thijs, V Gomes Fernandes, J Beaudry, M Cote, R Hoyte, K Lebrun, L Mackey, A Sahlas, D Selchen, D Spence, J Teal, P Winger, M Matamala, G Cifkova, R Kalita, Z Rektor, I Rosolova, H Vaclavik, D Boysen, G Klingenberg, H Hillbom, M Numminen, H Pilke, A Salmivaara, A Alamowitch, S Boulliat, J De Broucker, T Chollet, F Mahagne, M Milandre, L Moulin, T Milonas, I Stathis, P Vogiatzoglou, D Bornstein, N Honigman, S Lampl, Y Streifler, J Capurso, A Comi, G Ferrarese, C Gandolfo, C Poloni, M Senin, U Rangel Guerra, R Boon, A De Keyser, J De Kort, P Haas, J Kamphuis, D Koudstaal, P Anderson, N Singh, G Czlonkowska, A Drozdowski, W Gralewski, Z Kozubski, W Kuczynska Zardzewialy, A Podemski, R Stelmasiak, Z Szczudlik, A Da Costa Correia, C Ferro, J Salgueiro e., C Lietava, J Raslova, K Carr, J Gardiner, J Kruger, A Alvarez Sabin, J Chamorro, A Diez Tejedor, E Fernández, O Trejo Gabriel y., G González Marcos, J Egido Herrero, J Jiménez Martínez, M Lago Martin, A Mostacero Miguel, E Vivancos Mora, J Moltó, J Viguera Romero, J Cuartero Rodriguez, E Rubio, F Serena, J Laska, A Leijd, B Strand, T Terent, A Waegner, A Wallén, T Baumgartner, R Hungerbühler, H Lyrer, P Mattle, H Bath, P Ekpo, E Freeman, A Lees, K Macleod, M Sharma, A Shetty, H Albers, G Benavente, O Book, D Broderick, J Calder, C Carlini, W Chaturvedi, S Chippendale, T Coull, B Davis, P Devlin, T Dick, A Dooneief, G Duff, R Estronza, N Forteza, A Frankel, M Frey, J Friday, G Goldstein, J Hammer, M Harris, J Harper, W Hendin, B Hess, D Hinton, R Hollander, J Hughes, R Kasner, S Kent, T Kim, L Kirshner, H Ledbetter, L Lee Kwen, P Levin, K Libman, R Matlock, J Mcdowell, P McGee F., J Meyer, B Minagar, A Moussouttas, M Munson, R Nash, M Nassief, A Orr, S Ratinov, G Salanga, V Silliman, S Singer, R Smith, D Sullivan, H Tietjen, G Thaler, D Tuchman, M Uskavitch, D Verro, P Vicari, R Weinstein, R Wilterdink, J Zweifler, R De Bastos, M Goldstein, LB Welch, KMA SPARCL investigators Bogousslavsky J Goldstein LB Zivin J Clark W Dávalos A Kaste M Leiter L Altafullah I Graham G Glahn J Jiménez Hernández D MacWalter R Scott R Shuaib A Sivenius J Stipal R Hart R Marsh J Norrving B Pocock S Sacco R Easton J Brown M Nagy Z Whisnant J O'Neill B Kleber F LaBlanche JM Welty F Crimmins D Davis S Dimmitt S Donnan G Frayne J Freilich D Zagami A Mikocki J Schmidauer C Schmidt R De Bleecker J Deceuninck F Tack P Thijs V Gomes Fernandes J Beaudry M Cote R Hoyte K Lebrun LH Mackey A Sahlas D Selchen D Spence JD Teal P Winger M Matamala G Cifkova R Kalita Z Rektor I Rosolova H Vaclavik D Boysen G Klingenberg H Sillesen H Hillbom M Numminen H Pilke A Salmivaara A Alamowitch S Amarenco P Boulliat J De Broucker T Chollet F Mahagne MH Milandre L Moulin T Milonas I Stathis P Vogiatzoglou D Bornstein N Honigman S Lampl Y Streifler J Capurso A Comi G Gandolfo C Poloni M Senin U Rangel Guerra R Boon AM De Keyser JH De Kort PL Haas JA Kamphuis DJ Koudstaal PJ Anderson N Singh G Czlonkowska A Drozdowski W Gralewski Z Kozubski W Kuczynska Zardzewialy A Podemski R Stelmasiak Z Szczudlik A Da Costa Correia C Ferro J Salgueiro e. Cunha L Lietava J Raslova K Carr J Gardiner J Kruger A Alvarez Sabin J Chamorro A Diez Tejedor E Fernández O Trejo Gabriel y. Galán J González Marcos J Egido Herrero J Jiménez Martínez M Lago Martin A Mostacero Miguel E Vivancos Mora J Moltó J Viguera Romero J Cuartero Rodriguez E Rubio F Serena J Laska AC Leijd B Strand T Terent A Waegner A Wallén T Baumgartner R Hungerbühler H Lyrer P Mattle H Bath PM Ekpo EB Freeman A Lees KR MacLeod MJ MacWalter RS Sharma AK Shetty HG Albers G Benavente O Book D Broderick J Calder C Carlini W Chaturvedi S Chippendale T Coull B Davis P Devlin T Dick A Dooneief G Duff R Estronza N Forteza A Frankel M Frey J Friday G Goldstein J Hammer M Harris J Harper W Hendin B Hess D Hinton R Hollander J Hughes R Kasner S Kent T Kim L Kirshner H LaMonte M Ledbetter L Lee Kwen P Levin K Libman R Matlock J McDowell P McGee F. Jr Meyer B Minagar A Moussouttas M Munson R Nash M Nassief A Orr S Ratinov G Salanga V Silliman S Singer R Smith D Sullivan H Tietjen G Thaler D Tuchman M Uskavitch D Verro P Vicari R Weinstein R Wilterdink J Zweifler R De Bastos M. FERRARESE, CARLO Goldstein, L Amarenco, P Lamonte, M Gilbert, S Messig, M Callahan, A Hennerici, M Sillesen, H Welch, K Sparcl, I Bogousslavsky, J Zivin, J Clark, W Dávalos, A Kaste, M Leiter, L Altafullah, I Graham, G Glahn, J Jiménez Hernández, D Macwalter, R Scott, R Shuaib, A Sivenius, J Stipal, R Hart, R Marsh, J Norrving, B Pocock, S Sacco, R Easton, J Brown, M Nagy, Z Whisnant, J O'Neill, B Kleber, F Lablanche, J Welty, F Crimmins, D Davis, S Dimmitt, S Donnan, G Frayne, J Freilich, D Zagami, A Mikocki, J Schmidauer, C Schmidt, R De Bleecker, J Deceuninck, F Tack, P Thijs, V Gomes Fernandes, J Beaudry, M Cote, R Hoyte, K Lebrun, L Mackey, A Sahlas, D Selchen, D Spence, J Teal, P Winger, M Matamala, G Cifkova, R Kalita, Z Rektor, I Rosolova, H Vaclavik, D Boysen, G Klingenberg, H Hillbom, M Numminen, H Pilke, A Salmivaara, A Alamowitch, S Boulliat, J De Broucker, T Chollet, F Mahagne, M Milandre, L Moulin, T Milonas, I Stathis, P Vogiatzoglou, D Bornstein, N Honigman, S Lampl, Y Streifler, J Capurso, A Comi, G Ferrarese, C Gandolfo, C Poloni, M Senin, U Rangel Guerra, R Boon, A De Keyser, J De Kort, P Haas, J Kamphuis, D Koudstaal, P Anderson, N Singh, G Czlonkowska, A Drozdowski, W Gralewski, Z Kozubski, W Kuczynska Zardzewialy, A Podemski, R Stelmasiak, Z Szczudlik, A Da Costa Correia, C Ferro, J Salgueiro e., C Lietava, J Raslova, K Carr, J Gardiner, J Kruger, A Alvarez Sabin, J Chamorro, A Diez Tejedor, E Fernández, O Trejo Gabriel y., G González Marcos, J Egido Herrero, J Jiménez Martínez, M Lago Martin, A Mostacero Miguel, E Vivancos Mora, J Moltó, J Viguera Romero, J Cuartero Rodriguez, E Rubio, F Serena, J Laska, A Leijd, B Strand, T Terent, A Waegner, A Wallén, T Baumgartner, R Hungerbühler, H Lyrer, P Mattle, H Bath, P Ekpo, E Freeman, A Lees, K Macleod, M Sharma, A Shetty, H Albers, G Benavente, O Book, D Broderick, J Calder, C Carlini, W Chaturvedi, S Chippendale, T Coull, B Davis, P Devlin, T Dick, A Dooneief, G Duff, R Estronza, N Forteza, A Frankel, M Frey, J Friday, G Goldstein, J Hammer, M Harris, J Harper, W Hendin, B Hess, D Hinton, R Hollander, J Hughes, R Kasner, S Kent, T Kim, L Kirshner, H Ledbetter, L Lee Kwen, P Levin, K Libman, R Matlock, J Mcdowell, P McGee F., J Meyer, B Minagar, A Moussouttas, M Munson, R Nash, M Nassief, A Orr, S Ratinov, G Salanga, V Silliman, S Singer, R Smith, D Sullivan, H Tietjen, G Thaler, D Tuchman, M Uskavitch, D Verro, P Vicari, R Weinstein, R Wilterdink, J Zweifler, R De Bastos, M Goldstein, LB Welch, KMA SPARCL investigators Bogousslavsky J Goldstein LB Zivin J Clark W Dávalos A Kaste M Leiter L Altafullah I Graham G Glahn J Jiménez Hernández D MacWalter R Scott R Shuaib A Sivenius J Stipal R Hart R Marsh J Norrving B Pocock S Sacco R Easton J Brown M Nagy Z Whisnant J O'Neill B Kleber F LaBlanche JM Welty F Crimmins D Davis S Dimmitt S Donnan G Frayne J Freilich D Zagami A Mikocki J Schmidauer C Schmidt R De Bleecker J Deceuninck F Tack P Thijs V Gomes Fernandes J Beaudry M Cote R Hoyte K Lebrun LH Mackey A Sahlas D Selchen D Spence JD Teal P Winger M Matamala G Cifkova R Kalita Z Rektor I Rosolova H Vaclavik D Boysen G Klingenberg H Sillesen H Hillbom M Numminen H Pilke A Salmivaara A Alamowitch S Amarenco P Boulliat J De Broucker T Chollet F Mahagne MH Milandre L Moulin T Milonas I Stathis P Vogiatzoglou D Bornstein N Honigman S Lampl Y Streifler J Capurso A Comi G Gandolfo C Poloni M Senin U Rangel Guerra R Boon AM De Keyser JH De Kort PL Haas JA Kamphuis DJ Koudstaal PJ Anderson N Singh G Czlonkowska A Drozdowski W Gralewski Z Kozubski W Kuczynska Zardzewialy A Podemski R Stelmasiak Z Szczudlik A Da Costa Correia C Ferro J Salgueiro e. Cunha L Lietava J Raslova K Carr J Gardiner J Kruger A Alvarez Sabin J Chamorro A Diez Tejedor E Fernández O Trejo Gabriel y. Galán J González Marcos J Egido Herrero J Jiménez Martínez M Lago Martin A Mostacero Miguel E Vivancos Mora J Moltó J Viguera Romero J Cuartero Rodriguez E Rubio F Serena J Laska AC Leijd B Strand T Terent A Waegner A Wallén T Baumgartner R Hungerbühler H Lyrer P Mattle H Bath PM Ekpo EB Freeman A Lees KR MacLeod MJ MacWalter RS Sharma AK Shetty HG Albers G Benavente O Book D Broderick J Calder C Carlini W Chaturvedi S Chippendale T Coull B Davis P Devlin T Dick A Dooneief G Duff R Estronza N Forteza A Frankel M Frey J Friday G Goldstein J Hammer M Harris J Harper W Hendin B Hess D Hinton R Hollander J Hughes R Kasner S Kent T Kim L Kirshner H LaMonte M Ledbetter L Lee Kwen P Levin K Libman R Matlock J McDowell P McGee F. Jr Meyer B Minagar A Moussouttas M Munson R Nash M Nassief A Orr S Ratinov G Salanga V Silliman S Singer R Smith D Sullivan H Tietjen G Thaler D Tuchman M Uskavitch D Verro P Vicari R Weinstein R Wilterdink J Zweifler R De Bastos M. FERRARESE, CARLO
Publication Year :
2008
Abstract
BACKGROUND AND PURPOSE: In SPARCL, treatment with atorvastatin 80 mg daily reduced stroke risk in patients with recent stroke or TIA and no known coronary heart disease by 16% versus placebo over 4.9 years of follow-up. The purpose of this secondary analysis was to determine whether men and women similarly benefited from randomization to statin treatment. METHODS: The effect of sex on treatment-related reductions in stroke and other cardiovascular outcomes were analyzed with Cox regression modeling testing for sex by treatment interactions. RESULTS: Women (n=1908) constituted 40% of the SPARCL study population. At baseline, men (n=2823) were younger (62.0+/-0.21 versus 63.9+/-0.27 years), had lower systolic BPs (138.1+/-0.35 versus 139.5+/-0.47 mm Hg), higher diastolic BPs (82.2+/-0.20 versus 81.0+/-0.25 mm Hg), more frequently had a history of smoking (73% versus 38%), and had lower total cholesterol (207.0+/-0.54 versus 218.9+/-0.67 mg/dL) and LDL-C levels (132+/-0.45 versus 134+/-0.57 mg/dL) than women. Use of antithrombotics and antihypertensives were similar. After prespecified adjustment for region, entry event, time since event, and age, there were no sex by treatment interactions for the combined risk of nonfatal and fatal stroke (treatment Hazard Ratio, HR=0.84, 95% CI 0.68, 1.02 in men versus HR=0.84, 95% CI 0.63, 1.11 in women; treatment x sex interaction P=0.99), major cardiac events (HR=0.61, 95% CI 0.42, 0.87 in men versus HR=0.76, 95% CI 0.48, 1.21 in women; P=0.45), major cardiovascular events (HR=0.78, 95% CI 0.65, 0.93 in men versus HR=0.84, 95% CI 0.65, 1.07 in women; P=0.63), revascularization procedures (HR=0.50, 95% CI 0.37, 0.67 in men versus HR=0.76, 95% CI 0.46, 1.24 in women; P=0.17), or any CHD event (HR=0.54, 95% CI 0.41, 0.72 in men versus 0.67 95% CI 0.46, 0.98 in women; P=0.40). CONCLUSIONS: Stroke and other cardiovascular events are similarly reduced with atorvastatin 80 mg/d in men and women with recent stroke or TIA.
Details
Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1346404232
Document Type :
Electronic Resource