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Abstract Background: There have been many reports of topical steroids treatment for the face causing perioral dermatitis, steroid acne, and steroid rebound phenomenon. Objective: To assess patient reported outcomes in [...]

The objective of the present study was to report the first confirmed case of digital dermatitis in Greece, emphasizing to the clinical appearance of the disease and to discuss some potential mechanisms concerning the entrance and the contagiousness of the disease in a new herd. The outbreak occurred in a new dairy farm of 60 primiparous Holstein cows in Thessaloniki region. All the animals had been purchased as pregnant heifers five months before the onset of the disease and were clinically healthy without any abnormality on their limbs at their arrival in the herd. At the time of our visit a detailed clinical history was obtained and all cows of the herd were examined for lesions of digital dermatitis. Skin biopsies were taken from each affected cow for bacteriological examinations. The clinical examination revealed that 22 animals had lesions of digital dermatitis. The diagnosis was based on the typical clinical appearance of the disease and was confirmed by the detection of Treponema on the smears from biopsy materials. The majority of the animals were affected during the first 2-3 months of lactation and their mean lameness score was 2.68. The present study reported the first confirmed case of digital dermatitis in Greece and provided evidence that the disease can be entered in a farm by clinically healthy animals but certain initiating conditions should be met in order the to have clinical manifestation of the disease. Key words: Digital dermatitis, contagiousness, new herd, dairy cows, INTRODUCTION Digital dermatitis is an important disease of the feet of cattle and is presented as painful, erosive ulcerations of the limb, usually located on the skin of the posterior [...]

Background: Hydrocortisone butyrate (HCB) is currently marketed as a cream, ointment, and solution. A new lotion formulation of hydrocortisone butyrate 0.1% (Locoid[R] lotion) has been developed and evaluated. Objective: The objective of this study was to evaluate the efficacy and safety of HCB 0.1% lotion compared to the vehicle in subjects aged 3 months to less than 18 years with mild to moderate atopic dermatitis (AD). Methods: In this multicenter double-blind study, 284 subjects with mild to moderate AD were randomized 1:1 to receive HCB 0.1% lotion or the vehicle for a duration of 4 weeks. 'Treatment success' was defined as those subjects with a final Physician Global Assessment (PGA) score of 0 or 1 that had at least a 2-point reduction in the PGA score from baseline to day 29. Safety was assessed by monitoring adverse events. Results: Analyses of the final PGA score showed a significant treatment effect (P Limitations: The study did not assess the durability of the treatment effects (ie, safety and efficacy) after completion of the 4-week treatment period nor the potential need for longer term therapy given the chronic nature of AD. Conclusion: Results demonstrate the safety and efficacy of HCB 0.1% lotion in the treatment of mild to moderate AD in children 3 months to 18 years of age., Introduction Topical corticosteroids have become the cornerstone of treatment for a variety of inflammatory dermatoses, including atopic dermatitis (AD), eczema, and psoriasis. A wide selection of topical corticosteroid products is [...]

Abstract We present a case of a 55-year-old female with breast cancer who developed radiation recall dermatitis (RRD) 3 years later after administration of levofloxacin. A vast majority of cases [...]

BACKGROUND: Trichloroethylene (TCE) is used extensively as an industrial solvent and has been recognized as one of the major environmental pollutants. To date, > 200 cases of TCE-induced hypersensitivity dermatitis among exposed workers have been reported worldwide, and TCE exposure has become one of the critical occupational health issues in Asia. OBJECTIVES: The study aimed to identify genetic susceptible biomarkers associated with the TCE-induced hypersensitivity dermatitis in genes located in the human leukocyte antigen (HLA) region. METHODS: From 1998 to 2006, 121 cases with TCE-induced hypersensitivity dermatitis and 142 tolerant controls were recruited into the population-based case-control study. We determined HLA alleles B, DRB1, DQA1, and DQB1, by sequence-based typing. p-Values were corrected for comparisons of multiple HLA alleles. In addition, we compared and analyzed the structure character of amino acid residues of HLA molecules found in participants. RESULTS: We obtained complete genotyping data of 113 cases and 142 controls. The allele HLA-B*1301 was present in 83 (73.5%) of 113 patients compared with 13 (9.2%) of 142 tolerant workers (odds ratio = 27.5; 95% confidence interval, 13.5-55.7; corrected p = 1.48 X [10.sup.-21]). In addition, the HLA-B*44 alleles were present in 6.2% (7/113) of patients, but were absent in TCE-tolerant workers. Residue 95 shared by HLA-B*1301 and HLA-B*44 molecules formed a different pocket F than other residues. CONCLUSIONS: The allele HLA-B*1301 is strongly associated with TCE-induced hypersensitivity dermatitis among exposed workers and might be used as a biomarker to predict high risk individuals to TCE. KEY WORDS: biomarkers, genetic polymorphism, human leukocyte antigen, hypersensitivity dermatitis, trichloroethylene. Environ Health Perspect 115:1553-1556 (2007). doi:10.1289/ehp.10325 available via http://dx.doi.org/ [Online 24 August 2007], Trichloroethylene (TCE) is known as a major pollutant that affects both the occupational and general environment. It has been used as an industrial degreasing agent, solvent, and extraction agent for [...]

Byline: Yi. Lai, Yik. Yew Background: Hand dermatitis is a common, chronic relapsing skin disease, resulting from a variety of causes including endogenous predisposition and environmental exposures to irritants and [...]

ABSTRACT Interstitial granulomatous dermatitis is most commonly associated with rheumatoid arthritis (RA) but may be induced by medications as well. Darifenacin is a muscarinic antagonist which was FDA approved for [...]

Byline: Paula. Torres-Camacho, Andres. Tirado-Sanchez, Rosa. Ponce-Olivera Sir, Erythroderma, first described by Hebra in 1868, is an inflammatory disorder characterized by erythema and scaling involving more than 90% of the [...]

Byline: M. Raksha, Y. Marfatia Two hundred patients (112 males and 88 females) with cutaneous drug eruption were studied. The aim was to recognize the offending drug, to evaluate mortality [...]

Byline: Shapour. Omidvari, Hojjatollah. Saboori, Mohammad. Mohammadianpanah, Ahmad. Mosalaei, Niloofar. Ahmadloo, Mohammad. Mosleh-Shirazi, Farideh. Jowkar, Soha. Namaz Background: Although acute radiation dermatitis (ARD) is a common side-effect of radiotherapy (RT), [...]

Byline: Chembolli. Lakshmi, C. Srinivas Background: Parthenium dermatitis is a major problem in urban and rural India. Patients with severe allergic rhinitis due to exposure to pollens of parthenium are [...]

To the Editor: Recently, Pascal Del Giudice et al. published an interesting article (1) about dermatitis in France caused by Pyemotes ventricosus in which they highlight the presence of the [...]

Investigators have concluded that pimecrolimus application does not translate into clinically meaningful benefit for patients with cetuximab-related facial dermatitis. A recently published study enrolled 24 patients with metastatic colorectal cancer [...]

Sponsored by Tufts Medical Center; American Contact Dermatitis Society (ACDS). Hives affects 10-25% of the population worldwide at some time during their lifetime. Hives are itchy transient swellings of the [...]