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Purpose: To investigate whether the image quality of a specific deep learning-based synthetic CT (sCT) of the cervical spine is noninferior to conventional CT. Method: Paired MRI and CT data were collected from 25 consecutive participants (≥ 50 years) with cervical radiculopathy. The MRI exam included a T1-weighted multiple gradient echo sequence for sCT reconstruction. For qualitative image assessment, four structures at two vertebral levels were evaluated on sCT and compared with CT by three assessors using a four-point scale (range 1–4). The noninferiority margin was set at 0.5 point on this scale. Additionally, acceptable image quality was defined as a score of 3–4 in ≥ 80% of the scans. Quantitative assessment included geometrical analysis and voxelwise comparisons. Results: Qualitative image assessment showed that sCT was noninferior to CT for overall bone image quality, artifacts, imaging of intervertebral joints and neural foramina at levels C3-C4 and C6-C7, and cortical delineation at C6-C7. Noninferiority was weak to absent for cortical delineation at level C3-C4 and trabecular bone at both levels. Acceptable image quality was achieved for all structures in sCT and CT, except for trabecular bone in sCT and level C6-C7 in CT. Geometrical analysis of the sCT showed good to excellent agreement with CT. Voxelwise comparisons showed a mean absolute error of 80.05 (±6.12) HU, dice similarity coefficient (cortical bone) of 0.84 (±0.04) and structural similarity index of 0.86 (±0.02). Conclusions: This deep learning-based sCT was noninferior to conventional CT for the general visualization of bony structures of the cervical spine, artifacts, and most detailed structure assessments.