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4 results on '"Dedeoğlu, Savaş"'

1. Prevalence and Characteristics of Ascending Aorta Dilatation in Pediatric Patients with Bicuspid Aortic Valve and Aortic Valve Stenosis: A Cross-Sectional Analysis.

Author

Dedeoğlu, Savaş, Coşkun, Yusuf İskender, and Bornaun, Helen

Subjects
AORTIC valve diseases, AORTIC stenosis, AORTA, PEDIATRICS, ECHOCARDIOGRAPHY
Abstract

Objective: We aim to examine the prevalence and characteristics of ascending aorta (AA) dilatation in pediatric patients, specifically focusing on its relationship with the bicuspid aortic valve (BAV) and aortic valve stenosis (AS). We also seek to identify potential risk factors and clinical implications of AA dilatation within this population. Materials and Methods: In this retrospective cross-sectional study, 71 pediatric patients who underwent echocardiography between 2010 and 2022 were analyzed. AA dilatation is seen in connective tissue disorders and in BAV. Our objective was to look at the potential diagnoses for pediatric AA dilatation, focusing on associated aortic valve diseases. Patients with genetic syndromes, congenital heart defects, or other cardiac conditions were excluded. Aortic measurements were taken using standard techniques, and z-scores were calculated. Statistical analyses were performed to evaluate associations between aortic dilatation, valvular conditions, and other variables. Results: The median age of 71 patients was 9 years (1 day-18 years). AA dilation was common in patients with AS (36%) and BAV (47%). Isolated aortic root dilation was observed in 49% of cases. AA z-scores were statistically higher in BAV patients (p=0.034), but no difference was found in aortic root z-scores between BAV and non-BAV patients (p=0.117). AA z-scores correlated with aortic root z-scores and BAV presence (p=0.037, p=0.033). Patients with AS had smaller aortic root z-scores compared to those without AS (p=0.003). Smaller aortic root z-scores were also found in patients with both AS and BAV compared to those without either condition (p=0.0001). We could not find a statistically significant difference in AA dilatation in patients with and without AS. Conclusion: AA dilatation is a significant concern in pediatric patients with BAV, especially when AS is present. Routine echocardiography is essential for monitoring and early detection of aortic dilatation. Further studies are needed to understand the long-term implications and to optimize diagnostic approaches. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Experiences in Patent Ductus Arteriosus Closure of Preterm Infants Transported to Another Center for Surgical Ligation.

Author

Dedeoğlu, Savaş and Şaşmazel, Ahmet

Subjects
*STATISTICS, *PATENT ductus arteriosus, *INTRACRANIAL hemorrhage, *RETROSPECTIVE studies, *MANN Whitney U Test, *TREATMENT effectiveness, *ARTIFICIAL respiration, *SEPSIS, *T-test (Statistics), *PEARSON correlation (Statistics), *COMPARATIVE studies, *HOSPITAL care, *BIRTH weight, *DESCRIPTIVE statistics, *CHI-squared test, *BRONCHOPULMONARY dysplasia, *DATA analysis software, *DATA analysis, *LIGATURE (Surgery)
Abstract

Objective: The timing of surgical patent ductus arteriosus ligation in preterm infants remains controversial. Early ligation (<2 or 3 weeks of life) benefits preterm infants with a lower incidence of bronchopulmonary dysplasia and necrotizing enterocolitis. We present patent ductus arteriosus ligation experience in premature infants who had been transported for closure to an outside centre other than the hospital they were hospitalized. Materials and Methods: We retrospectively evaluated 17 consecutive patients who had undergone surgery of premature infant patent ductus arteriosus closure during the period of March 2009-December 2020. Patent ductus arteriosus had been clipped in 17 patients. Results: The median birth weight and age were 930 g and 28 gestation weeks, respectively. The birth age of the sub-groups were A: ≤28 weeks and B: >28 weeks and birthweight were group I: ≤800 g and group II: >800 g. The median day of PDA ligation wasa 20 days, and patients with birthweight ≤800 g were ligated later than patients weighing >800 g. Two patients had intracranial hemorrhage, 6 had bronchopulmonary dysplasia, and 2 were dead. We found that exposure to large patent ductus arteriosus and low birth age in preterm babies was associated with longer hospitalization duration, preoperative mechanical ventilation time, and sepsis. Conclusion: Infants exposed to moderate-to-large patent ductus arteriosus requiring intubation and resistant to medical therapy for more than 2 weeks should have surgical ligation as soon as possible. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Spontaneous Closure Left Ventricular to Right Atrial Shunt Subaortic Ridge and Aortic Valve Prolapse in 685 Patients With Ventricular Septal Defect at up to 11 Years Follow Up

Author

Eroğlu, Ayşe, Öztunç, Emine Funda, Saltık, İrfan Levent, Bakari, Süleyman, Dedeoğlu, Savaş, and Güven, Özen

Subjects
cardiovascular system, cardiovascular diseases
Abstract

The charts of 685 patients with ventricular septal defect were reviewed to determine spontaneous closure left ventricular to right atrial shunt subaortic ridge and aortic valve prolapse Patients had been followed up one month to 10 9 years mean 3±2 5 years median 2 2 years with echocardiography Ventricular septal defect was perimembraneous in 450 65 7 muscular inlet in 5 0 7 trabecular muscular in 211 30 8 muscular outlet in 16 2 3 and doubly committed subarterial in 3 05 The ventricular septal defect closed spontaneously in 186 of 685 patients 27 at ages of 40 days to 13 7 years mean 2 1±2 2 years median 1 3 years 68 of 450 perimembraneous ventricular septal defects 15 and 118 of 211 trabecular muscular defects 56 closed spontaneously p lt;0 05 The age of closure for perimembraneous defects mean 2 8±2 3 years was older than the age of closure for trabecular muscular defects mean 1 8±2 1 years p lt;0 003 Aneurysmal transformation was detected in 254 of 450 patients with perimembraneous defect 56 left ventricular to right atrial shunt in 38 8 4 subaortic ridge in 26 5 8 aortic valve prolapse in 53 11 7 and aortic regurgitation in 33 7 3 Aortic valve prolapse was detected in 5 of 16 patients with muscular outlet defect 31 and in one of 3 patients with doubly committed defect There was no statistical significance between the age at closure and the age of detection of aneurysmal transformation in patients with perimembraneous defect p=0 25 The age of detection of aneurysmal transformation was younger than the age of detection of left ventricular to right atrial shunt subaortic ridge and aortic valve prolapse p lt;0 03 0 05 and 0 0007 respectively Key words: Ventricular septal defect subaortic ridge aortic valve prolapse, Kendiliğinden kapanma sol ventrikül sağ atriyum şantı subaortik çıkıntı ve aort kapak prolapsusunu saptamak için 685 ventriküler septal defektli hastanın kayıtları incelendi Hastalar ekokardiyografi ile 1 ay ile 10 9 yıl ortalama 3±2 5 yıl izlendi Ventriküler septal defekt 450 sinde perimembranöz 65 7 5 inde müsküler giriş 0 7 211 inde trabeküler müsküler 30 8 16 sında müsküler çıkış 2 3 ve 3 ünde doubly committed subarterial di 0 5 685 hastanın 186 sında ventriküler septal defekt 40 gün ile 13 7 yaş arasında değişen yaşlarda ortalama 2 1±2 22 yaş ortanca 1 3 yaş kendiliğinden kapandı 27 450 perimembranöz defektin 68 i 15 ve 211 trabeküler müsküler defektin 118 i 56 kendiliğinden kapandı p lt;0 005 Perimembranöz defektlerin kapanma yaşı ortalama 2 8±2 3 yaş trabeküler müsküler defektlerin kapanma yaşından ortalama 1 8±2 1 yaş daha büyüktü p lt;0 003 450 perimembranöz defektli hastanın 254 ünde 56 anevrizmal değişim 38 inde sol ventrikül sağ atriyum şant 8 4 26 sında subaortik çıkıntı 5 8 53 ünde aort kapak prolapsusu 11 7 ve 33 ünde aort yetersizliği 7 3 saptandı Aort kapak prolapsusu 16 müsküler çıkış defektli hastanın 5 inde 31 ve 3 doubly committed subarterial defektli hastanın birinde saptandı Perimembranöz defektli hastalarda defektin kapanma yaşı ile anevrizmal değişim saptanma yaşı arasında istatistiksel farklılık saptanmadı p=0 25 Anevrizmal değişim saptanma yaşı sol ventrikül sağ atriyum şantı subaortik çıkıntı ve aort kapak prolapsusu saptanma yaşından daha küçüktü sırasıyla p lt;0 03 0 05 ve 0 0007 Anahtar kelimeler: Ventriküler septal defekt subaortik çıkıntı aort kapak prolapsusu

Published
2014

4. Thalassemia Major'lu çocuklarda pankreas beta hücre fonksiyon bozukluğunda demir yükünün rolünün irdelenmesi

Author

Dedeoğlu, Savaş, Işık, Kutay, and Diğer

Subjects
Glucose tolerance test, Iron, Diabetes mellitus-type 1, Thalassemia, Pancreas, Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases
Abstract

64 ÖZET Beta Thalassemia Major, Akdeniz ülkelerinden başlayarak Orta Doğu ve Uzak Doğu' ya kadar uzanan bir kuşak içinde sık görülen, otozomal resesif geçiş gösteren, hemoglobinin beta zincirinin sentez hızının azalması veya olmaması sonucunda gelişen bir kan hastalığıdır. Bu çalışma p Thalassemia Major'lu hasta grubundaki demir yükünün pankreas beta hücre fonksiyonları üzerine etkisini görmek ve glukoz intoleransı varlığını araştırmak amacıyla planlandı. SSK Göztepe Eğitim Hastanesi Çocuk Kliniği Hematoloji Ünitesi tarafından izlenen, yaşlan 3 4/12-17 yıl ( ort. 9 8/12 ± 11/12 ) arasında değişen; 13' ü kız T si erkek, 12' si prepubertal 8' i pubertal toplam 20 beta talasemi majorlü hasta çalışma kapsamına alındı. OGTT sonrası serum glukoz, insülin ve c-peptid yanıtlan ölçüldü. Karaciğer ve pankreas MR'lan demir birikimini değerlendirmek için çekildi. Yakın zamandaki glukoz profilini görmek için HbAıc ve fruktozamin bakıldı. Hastalanmızın 4'ünde glukoz intoleransı tespit edildi. Glukoz eğrilerinden, yaşı küçük ve ailede diabet öyküsü müspet olan kardeş iki olgumuzun glukoz toleransının yakın zamanda bozulacağı görüldü. Böylece ailede diabet öyküsü müspet olan 10 yaş altındaki hastalannda OGTT ile izlenmesi gerektiği gösterildi. Glukoz toleransı normal olan hastalann OGTT'ye insülin ve c-peptid yanıtlannın düşük, normal ve yüksek olabileceği görüldü. Puberteyle birlikte insülin ve c-peptid artışının meydana geldiği tespit edildi. Glukoz toleransının bozuk olduğu grupta pankreas MR'mın anlamlı derecede bozuk olduğu saptandı. Glukoz intoleransı ve İBDM'un önlenebilmesi veya geciktirilmesi için şelasyon tedavisinin uygun dozda ve düzenli olarak yapılmasının, ailede diabet hastalığı olanlann erken yaşlarda, olmayanlann 10 yaşından sonra yıllık OGTT ile izlenmelerinin, glukoz toleransı bozuk olan thalassemik hastalarla birlikte, toleransı normal olan hiperinsülinemik hastalannda diyetetik rejime alınması gerektiği sonucuna vanldı. 70

Published
1995

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