1. Association of decreased muscle mass with reduced bone mineral density in patients with Graves’ disease
- Author
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Lingning Huang, Sunjie Yan, Yuxi Lin, Yuzhen Ke, Ximei Shen, Yimei Li, Yongze Zhang, and Fengying Zhao
- Subjects
Adult ,musculoskeletal diseases ,medicine.medical_specialty ,business.industry ,Muscles ,Graves' disease ,Endocrinology, Diabetes and Metabolism ,medicine.disease ,Graves Disease ,Cohort Studies ,Reduced bone mineral density ,Absorptiometry, Photon ,Cross-Sectional Studies ,Endocrinology ,Bone Density ,Internal medicine ,medicine ,Humans ,In patient ,Decreased muscle mass ,business - Abstract
Background The bone mineral density (BMD) did not increase significantly after the normalization of serum thyroid hormone levels. Studies on the effect of muscle mass on BMD in patients with Graves’ disease are scarce. This study aimed to determine the association of decreased muscle mass with reduced bone mineral density in patients with Graves’ disease. Methods A total of 758 patients with Graves’ at diagnosis (mean age 41.2 years) were enrolled for a cross-sectional study; of these, 287 patients were enrolled for a cohort study with a median follow-up of 24 months. Meanwhile, 1164 age- and sex-matched healthy controls participants were recruited. All participants underwent dual-energy x-ray absorptiometry and muscle mass index (ASMI) measurements. The changes in ASMI and BMD were calculated from the measurements made at a gap of 2 years. Results Compared with healthy controls participants, the BMD was still significantly lower after normalizing serum thyroid hormone levels (1.131 ± 0.268 vs. 1.07 ± 0.133, p
- Published
- 2022