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Association of an Overhydrated State With the Liver Fibrosis and Prognosis of Cirrhotic Patients
- Source :
- In Vivo
- Publication Year :
- 2020
- Publisher :
- Anticancer Research USA Inc., 2020.
-
Abstract
- Background/aim A bioimpedance analysis (BIA) can indicate an overhydrated state as the extracellular water/total body water (ECW/TBW) value. This study aimed to assess the clinical significance of this value in patients with chronic liver diseases (CLDs). Patients and methods A total of 552 CLD patients who received a liver biopsy and underwent anthropometric assessment and BIA-based body composition analysis were enrolled. The association of the ECW/TBW value with the liver fibrosis and nutritional status was assessed. The relationship between the ECW/TBW value and the prognosis of cirrhotic patients (N=209) was also evaluated. Results The ECW/TBW value increased as liver fibrosis progressed and was also related to decreased muscle mass/sarcopenia. The presence of overhydration was associated with a poor prognosis of cirrhotic patients. Conclusion An increased ECW/TBW value was associated with progressive liver fibrosis and malnutrition and related to the prognosis of cirrhotic patients.
- Subjects :
- Liver Cirrhosis
Male
Sarcopenia
Cancer Research
medicine.medical_specialty
Biopsy
Liver fibrosis
Body water
Nutritional Status
Gastroenterology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
fluids and secretions
0302 clinical medicine
Body Water
Internal medicine
Humans
Medicine
Body Weights and Measures
Clinical significance
Decreased muscle mass
Aged
Pharmacology
medicine.diagnostic_test
business.industry
Middle Aged
Anthropometry
Prognosis
medicine.disease
Bioimpedance Analysis
030220 oncology & carcinogenesis
Liver biopsy
Body Composition
Female
business
Biomarkers
Research Article
Subjects
Details
- ISSN :
- 17917549 and 0258851X
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- In Vivo
- Accession number :
- edsair.doi.dedup.....0f4ab9cdcb0dd034f58de9d3f4df9c76