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1. Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines.

Author

DeVelasco EA, Dekker HA, Antal P, Jalink KP, van Strijp JA, Verheul AF, Verhoef J, and Snippe H

Subjects
Animals, Cell Line, Immune Sera immunology, Macrophages immunology, Mice, Mice, Inbred BALB C, Phagocytosis immunology, Polysaccharides immunology, Quillaja Saponins, Adjuvants, Immunologic pharmacology, Bacterial Vaccines immunology, Opsonin Proteins immunology, Saponins pharmacology, Streptococcus pneumoniae immunology
Abstract

The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.

Published
1994
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