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Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines.
- Source :
-
Vaccine [Vaccine] 1994 Nov; Vol. 12 (15), pp. 1419-22. - Publication Year :
- 1994
-
Abstract
- The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.
- Subjects :
- Animals
Cell Line
Immune Sera immunology
Macrophages immunology
Mice
Mice, Inbred BALB C
Phagocytosis immunology
Polysaccharides immunology
Quillaja Saponins
Adjuvants, Immunologic pharmacology
Bacterial Vaccines immunology
Opsonin Proteins immunology
Saponins pharmacology
Streptococcus pneumoniae immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0264-410X
- Volume :
- 12
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 7887020
- Full Text :
- https://doi.org/10.1016/0264-410x(94)90151-1