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34 results on '"DeRosa, Peter"'

3. A Case of Acute Myeloid Leukemia-Associated Necrotizing Sweet Syndrome

Author

Strong, Jennifer, primary, Zhou, Albert E., additional, Alkaabba, Fahad, additional, Soldin, Danielle, additional, Moon, Joanne, additional, Alharthy, Hanan, additional, Syed, Owais, additional, Liu, Yuchen, additional, Turney, Kathryn, additional, Markidan, Janina, additional, Malone, Laura, additional, Lee, Seung Tae, additional, and DeRosa, Peter, additional

Published
2022
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4. Rapidly Enlarging Parotid Mass in a Person Living with HIV: A Case of Multiple Myeloma with Extramedullary Plasmacytoma.

Author

Novitskaya, Maria G., DeRosa, Peter A., Chen, David T., Khalil, Ahmed, Harfouch, Omar, O'Connor, Erin E., and Schmalzle, Sarah A.

Subjects
*PLASMACYTOMA, *EXTRAMEDULLARY diseases, *BLOOD protein electrophoresis, *HIV infections, *CAVERNOUS sinus, *HIV
Abstract

Objective: Challenging differential diagnosis. Background: The differential diagnosis for a parotid mass is broad, including infectious, autoimmune, and neoplastic etiologies. In people with HIV, regardless of viral suppression or immune status, neoplastic causes are more common. This report describes the evaluation of a woman with a large parotid mass, with an ultimate diagnosis of multiple myeloma with extramedullary plasmacytoma. Case Report: A 51-year-old woman with HIV infection presented with headache, weight loss, and right facial mass that was present for 5 years but more rapidly enlarging in the prior year. CD4 count was 234 cells/mL, and HIV RNA was 10 810 copies/mL. Physical examination was significant for a large deforming right-sided facial mass, decreased sensation in the V1 and V2 distributions, and right-sided ophthalmoplegia and ptosis. MRI and PET/CT scan confirmed a metabolically active large parotid mass with extension into the cavernous sinus. An IgG kappa monoclonal spike was present on serum protein electrophoresis. Incisional biopsy of the facial mass showed atypical lymphoid cells with plasmablastic and plasmacytic morphology with a high mitotic rate and proliferation index. She was diagnosed with R-ISS stage II IgG kappa multiple myeloma with extramedullary plasmacytoma, and initiated on chemotherapy, radiation, and antiretroviral therapy. Conclusions: A rapidly enlarging parotid mass should prompt timely evaluation and biopsy for definitive diagnosis, particularly in immunocompromised patients, including people with HIV. Extramedullary plasmacytomas have a more aggressive disease process in people with HIV and are associated with high-risk multiple myeloma and progression, as seen in this patient. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Refractory Splenic Marginal Zone Lymphoma Responsive to Combination Venetoclax and Bortezomib (Velcade) (V 2) Therapy.

Author

Roche, Kyle C., DeRosa, Peter A., Liu, Min-Ling, Nava, Victor E., and Aggarwal, Anita

Subjects
*LYMPHOMAS, *VENETOCLAX, *BORTEZOMIB, *CANCER patient care, *ONCOLOGY
Abstract

Standard treatment regimens for the management of patients with refractory splenic marginal zone lymphoma (SMZL) are currently unavailable. Here, we report a case of SMZL, which, after failing multiple therapeutics, demonstrated an impressive clinical response to combined Venetoclax and Velcade (V2), a treatment combination currently being investigated in the setting of refractory multiple myeloma. We also report a unique histopathology and mutational profile that may have important implications for the characterization and prognosis of SMZL. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Subcutaneous and Disseminated Infection in a Renal Transplant Patient.

Author

DeRosa, Peter A, Vostal, Alexander C, Nace, Heather, Niederhaus, Silke V, Putnam, Nicole E, Drachenberg, Cinthia, Papadimitrou, John C, and Singh, Zeba N

Subjects
*CHRONIC kidney failure, *CO-trimoxazole, *KIDNEY transplantation, *MYCOPHENOLIC acid, *LEG, *NYSTATIN, *ELECTRON microscopy, *VALGANCICLOVIR, *PREDNISONE, *TACROLIMUS, *NECROSIS, *RARE diseases
Abstract

The article presents a case-report of a 55-year-old male renal transplant patient who developed severe leg pain and "knots" in the lower extremities. It mentions that the diagnosis was Protothecosis caused by Prototheca wickerhamii, a rare disease caused by achlorophyllic algae, prevalent in the environment and particularly risky for immunocompromised individuals.

Published
2023
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23. Complement Inhibition as a Proposed Neuroprotective Strategy following Cardiac Arrest

Author

Zacharia, Brad E., Hickman, Zachary L., Grobelny, Bartosz T., DeRosa, Peter A., Ducruet, Andrew F., and Connolly, E. Sander

Subjects
Article Subject
Abstract

Out-of-hospital cardiac arrest (OHCA) is a devastating disease process with neurological injury accounting for a disproportionate amount of the morbidity and mortality following return of spontaneous circulation. A dearth of effective treatment strategies exists for global cerebral ischemia-reperfusion (GCI/R) injury following successful resuscitation from OHCA. Emerging preclinical as well as recent human clinical evidence suggests that activation of the complement cascade plays a critical role in the pathogenesis of GCI/R injury following OHCA. In addition, it is well established that complement inhibition improves outcome in both global and focal models of brain ischemia. Due to the profound impact of GCI/R injury following OHCA, and the relative lack of effective neuroprotective strategies for this pathologic process, complement inhibition provides an exciting opportunity to augment existing treatments to improve patient outcomes. To this end, this paper will explore the pathophysiology of complement-mediated GCI/R injury following OHCA.

Published
2009
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24. Complement Inhibition Promotes Endogenous Neurogenesis and Sustained Anti-Inflammatory Neuroprotection following Reperfused Stroke

Author

Ducruet, Andrew F., primary, Zacharia, Brad E., additional, Sosunov, Sergey A., additional, Gigante, Paul R., additional, Yeh, Mason L., additional, Gorski, Justin W., additional, Otten, Marc L., additional, Hwang, Richard Y., additional, DeRosa, Peter A., additional, Hickman, Zachary L., additional, Sergot, Paulina, additional, and Connolly, E. Sander, additional

Published
2012
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26. The surgical management of chronic subdural hematoma

Author

Ducruet, Andrew F., primary, Grobelny, Bartosz T., additional, Zacharia, Brad E., additional, Hickman, Zachary L., additional, DeRosa, Peter L., additional, Anderson, Kristen, additional, Sussman, Eric, additional, Carpenter, Austin, additional, and Connolly, E. Sander, additional

Published
2011
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27. Gain-of-function polymorphisms of cystathionine β-synthase and delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage

Author

Grobelny, Bartosz T., primary, Ducruet, Andrew F., additional, DeRosa, Peter A., additional, Kotchetkov, Ivan S., additional, Zacharia, Brad E., additional, Hickman, Zachary L., additional, Fernandez, Luis, additional, Narula, Reshma, additional, Claassen, Jan, additional, Lee, Kiwon, additional, Badjatia, Neeraj, additional, Mayer, Stephan A., additional, and Connolly, E. Sander, additional

Published
2011
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30. Manhattan still life

Author

Giovanni, Joseph, Harty, Mary, and DeRosa, Peter

Subjects
Women executives -- Homes and haunts, Apartments -- Decoration and finishing, Interior design -- Methods
Published
1987

34. Pyoderma Gangrenosum Occurring in the Setting of Hypercortisolism Associated With Adrenocortical Adenoma: A Pathophysiological Paradox.

Author

Wei C, Hazuka E, DeRosa P, Paulson JM, and Friedman AJ

Subjects
Adrenal Cortex Neoplasms complications, Adrenal Cortex Neoplasms immunology, Adrenal Cortex Neoplasms surgery, Adrenocortical Adenoma complications, Adrenocortical Adenoma immunology, Adrenocortical Adenoma surgery, Adult, Cushing Syndrome etiology, Female, Humans, Immunosuppressive Agents therapeutic use, Pyoderma Gangrenosum pathology, Pyoderma Gangrenosum therapy, Skin pathology, Treatment Outcome, Adrenal Cortex Neoplasms diagnosis, Adrenalectomy, Adrenocortical Adenoma diagnosis, Cushing Syndrome diagnosis, Pyoderma Gangrenosum immunology
Abstract

Pyoderma gangrenosum (PG) is a challenging, rare, ulcerating skin disease characterized by neutrophilic abundance and absence of infection, often associated with systemic diseases. We present a 25-year old previously healthy female with a 1.5-year history of treatment refractory PG. Features of Cushing’s syndrome such as facial plethora, striae, and lipodystrophy were noted on exam, which prompted several studies that ultimately revealed an adrenal adenoma. Following surgical excision of the adenoma, symptoms rapidly resolved and systemic immunosuppressants were discontinued. This rare case highlights the importance that adrenal adenoma and resultant Cushing’s syndrome may be a driver of PG despite the pathophysiologic paradox. J Drugs Dermatol. 2021;20(1):95-97. doi:10.36849/JDD.5566.

Published
2021
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