1. Influence of age on the effect of reduced renal function on outcomes in patients with coronary artery disease
- Author
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Fei Chen, Zhi-liang Zuo, Fang-yang Huang, Tian-li Xia, Bao-tao Huang, Hua Chai, Qiao Li, Xiao-bo Pu, Yi-yue Gui, Yong Peng, Mao Chen, and De-jia Huang
- Subjects
Coronary artery disease ,Ageing ,Renal insufficiency ,Prognosis ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Ageing is a risk factor for both coronary artery disease (CAD) and reduced renal function (RRF), and it is also associated with poor prognosis in patients with CAD or RRF. However, little is known about whether the impact of RRF on clinical outcomes are different in CAD patients at different age groups. This study aimed to investigate whether ageing influences the effect of RRF on long-term risk of death in patients with CAD. Methods A retrospective analysis was conducted using data from a single-center cohort study. Three thousand and two consecutive patients with CAD confirmed by coronary angiography were enrolled. RRF was defined as an estimated glomerular filtration rate (eGFR) of less than 60 ml/min. The primary endpoint in this study was all-cause mortality. Results The mean follow-up time was 29.1 ± 12.5 months and death events occurred in 275 cases (all-cause mortality: 9.2%). The correlation analysis revealed a negative correlation between eGFR and age (r = − 0.386, P
- Published
- 2019
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