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Target lesion calcification and risk of adverse outcomes in patients with drug-eluting stents
- Source :
- Herz. 40:1097-1106
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation.A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014). Abstracts from the 2012 and 2013 scientific meetings of the American College of Cardiology and American Heart Association were manually searched. Hazard ratios (HRs) were pooled using a fixed or random effects model in the context of heterogeneity.A total of 13 studies comprising 66,361 patients were included. Target lesion calcification was associated with an increased risk of all-cause mortality (HR = 1.41; 95 % CI = 1.27-1.56), cardiac death (HR = 1.97; 95 % CI = 1.68-2.31), myocardial infarction (HR = 1.33; 95 % CI = 1.13-1.57), target lesion revascularization (TLR; HR 1.47, 95 % CI 1.18-1.83), stent thrombosis (HR 1.63, 95 % CI 1.36-1.96), and major cardiovascular events (HR 1.37, 95 % CI 1.19-1.58). The results proved robust in subgroup analyses for TLR and stent thrombosis.Calcified target lesions are risk factors for adverse outcomes in the DES era. Further studies focusing on comprehensive therapy in patients with coronary calcification are urgently needed.
- Subjects :
- Male
Target lesion
Drug
medicine.medical_specialty
medicine.medical_treatment
media_common.quotation_subject
Comorbidity
Coronary Artery Disease
Risk Factors
medicine
Humans
Risk factor
Aged
media_common
Aged, 80 and over
business.industry
Incidence
Calcinosis
Stent
Percutaneous coronary intervention
Drug-Eluting Stents
medicine.disease
Causality
Survival Rate
Death, Sudden, Cardiac
Treatment Outcome
Drug-eluting stent
Meta-analysis
Female
Radiology
Cardiology and Cardiovascular Medicine
business
Calcification
Subjects
Details
- ISSN :
- 16156692 and 03409937
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Herz
- Accession number :
- edsair.doi.dedup.....82ca41f83c04f1833fade64ba5eec5ff