101 results on '"De Cicco F"'
Search Results
2. Correction to: Neuroendocrine neoplasms in the context of inherited tumor syndromes: a reappraisal focused on targeted therapies
- Author
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Ruggeri, R. M., Benevento, E., De Cicco, F., Fazzalari, B., Guadagno, E., Hasballa, I., Tarsitano, M. G., Isidori, A. M., Colao, A., and Faggiano, A.
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- 2023
- Full Text
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3. Radon Measurement Laboratories. An Educational Experience Based on School and University Cooperation
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De Cicco, F., Balzano, E., Limata, B. N., Masullo, M. R., Quarto, M., Roca, V., Sabbarese, C., and Pugliese, M.
- Abstract
There is a growing interest in engaging students and the general public about the meaning and objectives of doing science. When it is possible students can learn by actively engaging in the practices of science, conducting investigations, sharing ideas with their peers, teachers and scientists, learning to work with measuring apparatuses, to acquire and process data and use models so as to interpret phenomena. This is a process that requires a gradual collective growth. Schools and universities can both benefit from this cooperation. This paper presents activities of a project focusing on the radon survey in high schools. The ENVIRAD (environmental radioactivity) educational project involved about 2500 students and some tens of teachers in measurements while using solid state nuclear track detectors. This experience began about 15 years ago and is still carried out by various national projects managed by the same research group. The measurements and data analysis have been done in school laboratories and in the university radioactivity laboratory. Several hundred students were also involved in the transduction and signal processing. In some cases, pupils have also been involved in citizen awareness and the dissemination of this experience has kicked off a follow-up project explicitly addressed to citizens. The project has led to the opportunity to learn science through a real physics experiment. The students' enthusiasm allowed the collection of a relevant amount of data which benefitted both the regional survey on radon and the improvement of nuclear physics teaching at school. Through the project activities it was possible to recognize the interdisciplinary connections among different scientific disciplines connected to radioactivity.
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- 2017
- Full Text
- View/download PDF
4. Neuroendocrine neoplasms in the context of inherited tumor syndromes: a reappraisal focused on targeted therapies
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Ruggeri, R M, Benevento, E, De Cicco, F, Fazzalari, B, Guadagno, E, Hasballa, I, Tarsitano, M G, Isidori, A M, Colao, A, Faggiano A, NIKE group, Guarnotta, V, Ruggeri, R M, Benevento, E, De Cicco, F, Fazzalari, B, Guadagno, E, Hasballa, I, Tarsitano, M G, Isidori, A M, Colao, A, Faggiano, A, NIKE group, Guarnotta, V, and Faggiano, A
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Neuroendocrine neoplasm ,MEN4 ,Endocrinology ,MEN1 ,Endocrinology, Diabetes and Metabolism ,Von Hippel–Lindau (VHL) syndrome ,Targeted therapie ,Neurofibromatosis 1 (NF-1) ,Tuberous sclerosis (TSC) - Abstract
Purpose Neuroendocrine neoplasms can occur as part of inherited disorders, usually in the form of well-differentiated, slow-growing tumors (NET). The main predisposing syndromes include: multiple endocrine neoplasias type 1 (MEN1), associated with a large spectrum of gastroenteropancreatic and thoracic NETs, and type 4 (MEN4), associated with a wide tumour spectrum similar to that of MEN1; von Hippel-Lindau syndrome (VHL), tuberous sclerosis (TSC), and neurofibromatosis 1 (NF-1), associated with pancreatic NETs. In the present review, we propose a reappraisal of the genetic basis and clinical features of gastroenteropancreatic and thoracic NETs in the setting of inherited syndromes with a special focus on molecularly targeted therapies for these lesions. Methods Literature search was systematically performed through online databases, including MEDLINE (via PubMed), and Scopus using multiple keywords' combinations up to June 2022. Results Somatostatin analogues (SSAs) remain the mainstay of systemic treatment for NETs, and radiolabelled SSAs can be used for peptide-receptor radionuclide therapy for somatostatin receptor (SSTR)-positive NETs. Apart of these SSTR-targeted therapies, other targeted agents have been approved for NETs: the mTOR inhibitor everolimus for lung, gastroenteropatic and unknown origin NET, and sunitinib, an antiangiogenic tyrosine kinase inhibitor, for pancreatic NET. Novel targeted therapies with other antiangiogenic agents and immunotherapies have been also under evaluation. Conclusions Major advances in the understanding of genetic and epigenetic mechanisms of NET development in the context of inherited endocrine disorders have led to the recognition of molecular targetable alterations, providing a rationale for the implementation of treatments and development of novel targeted therapies.
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- 2023
5. Thirty years after Chernobyl: Long-term determination of 137Cs effective half-life in the lichen Stereocaulon vesuvianum
- Author
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Savino, F., Pugliese, M., Quarto, M., Adamo, P., Loffredo, F., De Cicco, F., and Roca, V.
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- 2017
- Full Text
- View/download PDF
6. Multi-parametric approach to the analysis of soil radon gas for its validation as geoindicator in two sites of the Phlegrean Fields caldera (Italy)
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De Cicco, F., Pugliese, M., Quarto, M., Roca, V., Sabbarese, C., Savino, F., Aquino, I., and De Cesare, W.
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- 2017
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7. Realization and characterization of a 220Rn source for calibration purposes
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Buompane, R., Roca, V., Sabbarese, C., De Cicco, F., Mattone, C., Pugliese, M., and Quarto, M.
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- 2013
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8. Dependence of the LR-115 radon detector calibration factor on track density
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De Cicco, F., Pugliese, M., Roca, V., and Sabbarese, C.
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- 2013
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9. Uterine perforation and small bowel incarceration 11 months after dilatation and curettage: sonographic and surgical findings
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De Cicco, A., Mascilini, F., Ludovisi, M., De Cicco, F., Scambia, G., and Testa, A. C.
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- 2017
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10. Epidemiology of pancreatic neuroendocrine neoplasms. a gender perspective
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Muscogiuri, G., Altieri, B., Albertelli, M., Dotto, A., Modica, R., Barrea, L., Fanciulli, G., Feola, T., Baldelli, R., Ruggeri, R. M., Gallo, M., Guarnotta, V., Malandrino, P., Messina, E., Venneri, M. A., Giannetta, E., Ferone, D., Colao, A., Faggiano, A., Bottiglieri, F., Campione, S., de Cicco, F., Dicitore, A., Ferrau, F., Grillo, F., Grossrubatscher, E., Guadagno, E., Isidori, A. M., Lania, A., Lenzi, A., Calzo, F. L., Pes, L., Pizza, G., Pofi, R., Puliani, G., Rainone, C., Razzore, P., Rizza, L., Rubino, M., Sbardella, E., Sesti, F., Vitale, G., Zatelli, M. C., Muscogiuri G, Altieri B, Albertelli M, Dotto A, Modica R, Barrea L, Fanciulli G, Feola T, Baldelli R, Ruggeri RM, Gallo M, Guarnotta V, Malandrino P, Messina E, Venneri MA, Giannetta E, Ferone D, Colao A, Faggiano A, Muscogiuri, G., Altieri, B., Albertelli, M., Dotto, A., Modica, R., Barrea, L., Fanciulli, G., Feola, T., Baldelli, R., Ruggeri, R. M., Gallo, M., Guarnotta, V., Malandrino, P., Messina, E., Venneri, M. A., Giannetta, E., Ferone, D., Colao, A., Faggiano, A., Bottiglieri, F., Campione, S., de Cicco, F., Dicitore, A., Ferrau, F., Grillo, F., Grossrubatscher, E., Guadagno, E., Isidori, A. M., Lania, A., Lenzi, A., Calzo, F. L., Pes, L., Pizza, G., Pofi, R., Puliani, G., Rainone, C., Razzore, P., Rizza, L., Rubino, M., Sbardella, E., Sesti, F., Vitale, G., and Zatelli, M. C.
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Male ,medicine.medical_specialty ,Cardiovascular diseases ,Epidemiology ,Gender ,Pancreatic neuroendocrine neoplasms ,Sex ,Type 2 diabetes ,Female ,Humans ,Middle Aged ,Pancreas ,Retrospective Studies ,Diabetes Mellitus, Type 2 ,Neuroendocrine Tumors ,Pancreatic Neoplasms ,Pancreatic neuroendocrine neoplasm ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Disease ,Neuroendocrine tumors ,Type 2 diabete ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Retrospective Studie ,Internal medicine ,Diabetes mellitus ,medicine ,gender ,Pancrea ,sex ,business.industry ,pancreatic neuroendocrine neoplasms ,Retrospective cohort study ,medicine.disease ,Cardiovascular disease ,cardiovascular diseases ,Natural history ,030220 oncology & carcinogenesis ,Pancreatitis ,epidemiology ,type 2 diabetes ,business ,Neuroendocrine Tumor ,Human - Abstract
Purpose: Pancreatic neuroendocrine neoplasms (PNENs) are a group of clinically rare and heterogeneous tumors of the pancreas. Currently there are no studies investigating the gender difference in PNEN susceptibility. Thus, the purpose of this study was aimed at examining how gender shapes risk factors, clinicopathological features, and comorbidities in PNENs. Methods: The study design consisted of an Italian multicenter, retrospective study. The study included all consecutive patients with PNENs followed at the participating centers. Two hundred and twenty-nine patients (105 males,124 females, age 54 ± 0.98 years) with PNENs were enrolled at the participating centers. The clinicopathological features (age, gender, BMI, histology, tumor size, tumor grade, distant metastasis, hormonal function, and diagnostic circumstances), comorbidities (cardiovascular diseases (CVD), pancreatitis, type 2 diabetes (T2DM), and potential risk factors (smoking and drinking) were included in the analysis. Results: Females were slightly prevalent (54.15%). PNENs were diagnosed at younger age in females compared to males (p = 0.04). The prevalence of CVD was significantly higher in males than in females (p = 0.006). In the female group, the presence of T2DM was significantly associated with higher tumor grade (p = 0.04) and metastatic disease (p = 0.02). The proportion of smokers and alcohol drinkers was significantly higher in the male group (p < 0.001). No significant gender differences were detected regarding the other parameters included in the analysis. Conclusions: This study has identified gender differences of PNENs in terms of age at diagnosis, associated comorbidities, and potential risk factors. A gender-tailored approach could become a potential strategy to better understand the natural history of PNENs and improve the effectiveness of PNENs clinical management.
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- 2020
11. Open issues on G3 neuroendocrine neoplasms: back to the future
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Zatelli, Maria Chiara, Guadagno, Elia, Messina, Erika, Lo Calzo, Fabio, Faggiano, Antongiulio, Colao, Annamaria, Albertelli, M., Bianchi, A., CIRCELLI, MARIA TERESA, De Cicco, F., Dicitore, A., Di Dato, C., MOLFETTA, MARIA TERESA, Fanciulli, G., Ferraù, F., Gallo, M., GIANNETTA, MASSIMO, Grillo, F., Grossrubatscher, E., Guarnotta, V., Isidori, A. M., Kara, E., MALANDRINO, CORRADO, Modica, R., Muscogiuri, G., Pizza, G., Razzore, P., Rota, F., Rubino, M., Ruggeri, R. M., Sciammarella, C., Vitale, G., Zatelli, Maria Chiara, Guadagno, Elia, Messina, Erika, Lo Calzo, Fabio, Faggiano, Antongiulio, Colao, Annamaria, Albertelli, M., Bianchi, A., Circelli, MARIA TERESA, De Cicco, F., Dicitore, A., Di Dato, C., Molfetta, MARIA TERESA, Fanciulli, G., Ferraù, F., Gallo, M., Giannetta, Massimo, Grillo, F., Grossrubatscher, E., Guarnotta, V., Isidori, A. M., Kara, E., Malandrino, Corrado, Modica, R., Muscogiuri, G., Pizza, G., Razzore, P., Rota, F., Rubino, M., Ruggeri, R. M., Sciammarella, C., and Vitale, G.
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0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Prognosi ,Endocrinology, Diabetes and Metabolism ,Neuroendocrine tumors ,Diagnosis ,G3 ,neuroendocrine tumors ,prognosis ,endocrinology ,diabetes and metabolism ,oncology ,cancer research ,NO ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Neuroendocrine tumor ,medicine ,Humans ,Prognosis ,Oncology ,Intensive care medicine ,business.industry ,medicine.disease ,Neuroendocrine Carcinomas ,Diabetes and Metabolism ,030104 developmental biology ,030220 oncology & carcinogenesis ,Neoplasm Grading ,business ,Diagnosi - Abstract
The recent recognition that grade 3 (G3) neuroendocrine neoplasms (NENs) can be divided into two different categories according to the histopathological differentiation, that is G3 neuroendocrine tumors (NETs) and G3 neuroendocrine carcinomas (NECs) has generated a lot of interest concerning not only the diagnosis, but also the differential management of such new group of NENs. However, several issues need to be fully clarified in order to put G3 NETs and G3 NECs in the right place. The aim of this review is to focus on those issues that are still undetermined starting from the current knowledge, evaluating the available evidence and the possible clinical implications.
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- 2018
12. Emerging Therapies in Pheochromocytoma and Paraganglioma: Immune Checkpoint Inhibitors in the Starting Blocks
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Fanciulli G., Di Molfetta S., Dotto A., Florio T., Feola T., Rubino M., de Cicco F., Colao A., Faggiano A., Albertelli M., Altieri B., Barrea L., Bottiglieri F., Campione S., Dicitore A., Ferone D., Ferrau F., Grossrubatscher E., Gallo M., Giannetta E., Grillo F., Guadagno E., Guarnotta V., Isidori A. M., Lania A., Lenzi A., Lo Calzo F., Malandrino P., Messina E., Modica R., Muscogiuri G., Pizza G., Pes L., Pofi R., Puliani G., Rainone C., Razzore P., Rizza L., Ruggieri R. M., Sbardella E., Sesti F., Venneri M. A., Vitale G., Zatelli M. C., Fanciulli G., Di Molfetta S., Dotto A., Florio T., Feola T., Rubino M., de Cicco F., Colao A., Faggiano A., Albertelli M., Altieri B., Barrea L., Bottiglieri F., Campione S., Dicitore A., Ferone D., Ferrau F., Grossrubatscher E., Gallo M., Giannetta E., Grillo F., Guadagno E., Guarnotta V., Isidori A.M., Lania A., Lenzi A., Lo Calzo F., Malandrino P., Messina E., Modica R., Muscogiuri G., Pizza G., Pes L., Pofi R., Puliani G., Rainone C., Razzore P., Rizza L., Ruggieri R.M., Sbardella E., Sesti F., Venneri M.A., Vitale G., Zatelli M.C., Fanciulli, G., Di Molfetta, S., Dotto, A., Florio, T., Feola, T., Rubino, M., de Cicco, F., Colao, A., Faggiano, A., Albertelli, M., Altieri, B., Barrea, L., Bottiglieri, F., Campione, S., Dicitore, A., Ferone, D., Ferrau, F., Grossrubatscher, E., Gallo, M., Giannetta, E., Grillo, F., Guadagno, E., Guarnotta, V., Isidori, A. M., Lania, A., Lenzi, A., Lo Calzo, F., Malandrino, P., Messina, E., Modica, R., Muscogiuri, G., Pizza, G., Pes, L., Pofi, R., Puliani, G., Rainone, C., Razzore, P., Rizza, L., Ruggieri, R. M., Sbardella, E., Sesti, F., Venneri, M. A., Vitale, G., and Zatelli, M. C.
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atezolizumab ,avelumab ,cemiplimab ,durvalumab ,immune checkpoint inhibitors ,ipilimumab ,nivolumab ,paraganglioma ,pembrolizumab ,pheochromocytoma ,lcsh:Medicine ,Ipilimumab ,Review ,Immune checkpoint inhibitor ,Pembrolizumab ,Bioinformatics ,Pheochromocytoma ,Avelumab ,03 medical and health sciences ,0302 clinical medicine ,Paraganglioma ,Atezolizumab ,Medicine ,Ate-zolizumab ,030304 developmental biology ,0303 health sciences ,business.industry ,lcsh:R ,General Medicine ,medicine.disease ,Clinical trial ,030220 oncology & carcinogenesis ,Nivolumab ,business ,medicine.drug - Abstract
Pheochromocytoma and paraganglioma are neuroendocrine neoplasms, originating in the adrenal medulla and in parasympathetic and sympathetic autonomic nervous system ganglia, respectively. They usually present as localized tumours curable with surgery. However, these tumours may exhibit heterogeneous clinical course, ranging from no/minimal progression to aggressive (progressive/metastatic) behavior. For this setting of patients, current therapies are unsatisfactory. Immune checkpoint inhibitors have shown outstanding results for several types of solid cancers. We therefore aimed to summarize and discuss available data on efficacy and safety of current FDA-approved immune checkpoint inhibitors in patients with pheochromocytoma and paraganglioma. After an extensive search, we found 15 useful data sources (four full-published articles, four supplements of scientific journals, seven ongoing registered clinical trials). The data we detected, even with the limit of the small number of patients treated, make a great expectation on the therapeutic use of immune checkpoint inhibitors. Besides, the newly detected predictors of response will (hopefully) be of great helps in selecting the subset of patients that might benefit the most from this class of drugs. Finally, new trials are in the starting blocks, and they are expected to shed in the next future new light on a therapy, which is considered a milestone in oncology.
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- 2020
13. Immune checkpoint blockade for Merkel cell carcinoma: actual findings and unanswered questions
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Gallo M., Guarnotta V., De Cicco F., Rubino M., Faggiano A., Colao A., Albertelli M., Altieri B., Ambrosetti E., Bianchi A., Bottiglieri L., Campione S., Carra S., Di Dato C., DiMolfetta S., Di Sarno A., Fanciulli G., Ferone D., Ferrau F., Giannetta E., Grillo F., Grossrubatscher E. M., Guadagno E., Isidori A., Lo Calzo F., Malandrino P., Martini C., Messina E., Modica R., Muscogiuri G., Pizza G., Razzore P., Rizza L., Ruggeri R. M., Sciammarella C., Vitale G., Zatelli M. C., Gallo, M., Guarnotta, V., De Cicco, F., Rubino, M., Faggiano, A., Colao, A., Albertelli, M., Altieri, B., Ambrosetti, E., Bianchi, A., Bottiglieri, L., Campione, S., Carra, S., Di Dato, C., Dimolfetta, S., Di Sarno, A., Fanciulli, G., Ferone, D., Ferrau, F., Giannetta, E., Grillo, F., Grossrubatscher, E. M., Guadagno, E., Isidori, A., Lo Calzo, F., Malandrino, P., Martini, C., Messina, E., Modica, R., Muscogiuri, G., Pizza, G., Razzore, P., Rizza, L., Ruggeri, R. M., Sciammarella, C., Vitale, G., Zatelli, M. C., and Gallo Marco, Guarnotta Valentina, De Cicco Federica, Rubino Manila, Faggiano Antongiulio, Colao Annamaria
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0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Avelumab ,Skin Neoplasms ,Prognosi ,medicine.medical_treatment ,Pembrolizumab ,Immune checkpoint inhibitor ,Cochrane Library ,B7-H1 Antigen ,Settore MED/13 - Endocrinologia ,03 medical and health sciences ,Immune checkpoint inhibitors ,0302 clinical medicine ,Merkel cell carcinoma ,Neuroendocrine tumours ,Neuroendocrine tumour ,medicine ,Animals ,Humans ,Skin Neoplasm ,Intensive care medicine ,business.industry ,Animal ,Antibodies, Monoclonal ,General Medicine ,Immunotherapy ,medicine.disease ,Prognosis ,Immune checkpoint ,Blockade ,Clinical trial ,Carcinoma, Merkel Cell ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Therapy ,business ,medicine.drug ,Human - Abstract
Purpose: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine carcinoma arising from the skin. We aimed to review and deal with some of the most relevant controversial topics on the correct use of immunotherapy for the treatment of MCC. Methods: The primary search was carried out via PubMed, EMBASE, and the Cochrane Library (until 31st May, 2018), while other articles and guidelines were retrieved from related papers or those referenced in these papers. Additionally, we performed an extensive search on ClinicalTrials.gov to gather information on the ongoing clinical trials related to this specific topic. Results: We performed an up-to-date critical review taking into account the results of both retrospective and prospective published studies evaluating these issues: Are there any predictive criteria of response to immunotherapy? What is the correct place of immunotherapy in the treatment algorithm of MCC? What is the best choice after immunotherapy failure? What to do with patients for whom immunotherapy is not been feasible or contraindicated? How long should immunotherapy be prolonged, and what follow-up should be offered after complete response? Conclusion: The therapeutic landscape of MCC is rapidly evolving: many open issues will probably be resolved, and many other questions are likely to arise in the next few years. The results of ongoing prospective clinical trials and of several other studies on these issues are eagerly awaited.
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- 2019
14. Bone Metastases in Neuroendocrine Neoplasms: From Pathogenesis to Clinical Management
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Altieri B., Di Dato C., Martini C., Sciammarella C., DI SARNO, ALFONSO, Colao A., Faggiano A., Albertelli M., AMBROSETTI, ENRICO MARIO, Bianchi A., Bottiglieri F., Campione S., Carra S., De Cicco F., Di Molfetta S., Fanciulli G., Ferone D., Ferrau F., Gallo M., Giannetta E., Grillo F., Maria E. G., Guadagno E., Guarnotta V., Isidori A., Lo Calzo F., Malandrino P., Messina E., Modica R., Muscogiuri G., Pizza G., Razzore P., Rizza L., Rubino M., Ruggeri R. M., Vitale G., Zatelli M. C., Altieri, B., Di Dato, C., Martini, C., Sciammarella, C., DI SARNO, Alfonso, Colao, A., Faggiano, A., Albertelli, M., Ambrosetti, ENRICO MARIO, Bianchi, A., Bottiglieri, F., Campione, S., Carra, S., De Cicco, F., Di Molfetta, S., Fanciulli, G., Ferone, D., Ferrau, F., Gallo, M., Giannetta, E., Grillo, F., Maria, E. G., Guadagno, E., Guarnotta, V., Isidori, A., Lo Calzo, F., Malandrino, P., Messina, E., Modica, R., Muscogiuri, G., Pizza, G., Razzore, P., Rizza, L., Rubino, M., Ruggeri, R. M., Vitale, G., and Zatelli, M. C.
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Oncology ,Cancer Research ,medicine.medical_specialty ,Prognosi ,Skeletal-related event ,education ,Skeletal related events ,030209 endocrinology & metabolism ,Review ,lcsh:RC254-282 ,Pathogenesis ,Bone metastases ,Bone microenvironment ,Denosumab ,Epithelial-to-mesenchymal transition ,Microrna ,Neuroendocrine neoplasms ,Prognosis ,Skeletal-related events ,Treatment ,03 medical and health sciences ,0302 clinical medicine ,bone metastases ,Quality of life ,Internal medicine ,medicine ,neuroendocrine neoplasms ,microRNA ,treatment ,medicine.diagnostic_test ,business.industry ,digestive, oral, and skin physiology ,denosumab ,Retrospective cohort study ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,skeletal-related events ,Neuroendocrine neoplasm ,Clinical Practice ,Bone metastase ,stomatognathic diseases ,Positron emission tomography ,Curative treatment ,030220 oncology & carcinogenesis ,epithelial-to-mesenchymal transition ,prognosis ,business ,bone microenvironment ,medicine.drug - Abstract
Bone represents a common site of metastases for several solid tumors. However, the ability of neuroendocrine neoplasms (NENs) to localize to bone has always been considered a rare and late event. Thanks to the improvement of therapeutic options, which results in longer survival, and of imaging techniques, particularly after the introduction of positron emission tomography (PET) with gallium peptides, the diagnosis of bone metastases (BMs) in NENs is increasing. The onset of BMs can be associated with severe skeletal complications that impair the patient’s quality of life. Moreover, BMs negatively affect the prognosis of NEN patients, bringing out the lack of curative treatment options for advanced NENs. The current knowledge on BMs in gastro-entero-pancreatic (GEP) and bronchopulmonary (BP) NENs is still scant and is derived from a few retrospective studies and case reports. This review aims to perform a critical analysis of the evidence regarding the role of BMs in GEP- and BP-NENs, focusing on the molecular mechanisms underlining the development of BMs, as well as clinical presentation, diagnosis, and treatment of BMs, in an attempt to provide suggestions that can be used in clinical practice.
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- 2019
15. Talus Bipartitus: A Rare Anatomical Variant Presenting as an Entrapment Neuropathy of the Tibial Nerve within the Tarsal Tunnel
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Abrego, M. O., De Cicco, F. L., Gimenez, N. E., Marquesini, M. O., Sotelano, P., Carrasco, M. N., and Santini Araujo, M. G.
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musculoskeletal diseases ,body regions ,animal structures ,Article Subject ,sense organs ,musculoskeletal system - Abstract
Tarsal tunnel syndrome is an entrapment neuropathy of the tibial nerve within the tarsal tunnel that lies beneath the retinaculum on the medial side of the ankle. It is often underdiagnosed. Talus bipartitus is a rare anatomical variant; only a few cases have been described in medical literature. We report a case of a 36-year-old female with tarsal tunnel syndrome secondary to a talus bipartitus undergoing surgical treatment with good clinical outcome. To our knowledge, talus bipartitus presenting as tarsal tunnel syndrome has no previous reports. Image studies and physical examination are crucial to reach precise diagnosis.
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- 2018
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16. Extensor Tendons Rupture after Volar Plating of Distal Radius Fracture Related to a Dorsal Radial Metaphyseal Bone Spur
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Abrego, M. O., primary, De Cicco, F. L., additional, Boretto, J. G., additional, Gallucci, G. L., additional, and De Carli, P., additional
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- 2018
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17. SIGNAL DECOMPOSITION AND ANALYSIS FOR THE IDENTIFICATION OF PERIODIC AND ANOMALOUS PHENOMENA IN RADON TIME-SERIES
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Sabbarese, C, primary, Ambrosino, F, additional, De Cicco, F, additional, Pugliese, M, additional, Quarto, M, additional, and Roca, V, additional
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- 2017
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18. Thirty years after Chernobyl: Long-term determination of 137 Cs effective half-life in the lichen Stereocaulon vesuvianum
- Author
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Savino, F., primary, Pugliese, M., additional, Quarto, M., additional, Adamo, P., additional, Loffredo, F., additional, De Cicco, F., additional, and Roca, V., additional
- Published
- 2017
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19. Omeprazole/SBA-15 mesoporous silicate compound embedded in alginate beads: a novel versatile gastro-resistant paediatric formulation
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De Cicco, F., Giovagnoli, Stefano, Aquino, R. P., and Del Gaudio, P.
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- 2015
20. Enclavado endomedular suprarrotuliano vs. infrarrotuliano en el tratamiento de fracturas diafisarias y distales de tibia: análisis comparativo y técnica quirúrgica
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Lionel Llano, María Liliana Soruco, De Cicco Franco Luis, Danilo Taype Zamboni, Carlos F. Sancineto, and Guido S. Carabelli
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abordaje suprarrotuliano ,fractura de tibia ,abordaje infrarrotuliano ,técnica quirúrgica ,Orthopedic surgery ,RD701-811 - Abstract
Introducción: Las fracturas diafisarias y distales de tibia son lesiones frecuentes en personas jóvenes que sufren un trauma de alta energía y en ancianos por un trauma de baja energía. El objetivo de este estudio fue comparar el tiempo quirúrgico, el uso de radioscopia, la evaluación funcional y el dolor en el tratamiento de fracturas diafisarias y distales de tibia mediante una técnica suprarrotuliana y una infrarrotuliana. Materiales y Métodos: Se realizó un estudio retrospectivo entre marzo de 2018 y octubre de 2019. La información de los pacientes se obtuvo de la historia clínica electrónica. Se incluyó a pacientes con fracturas diafisarias y distales de tibia. Se estudiaron y compararon los tiempos de radioscopia y de cirugía. El dolor posoperatorio se evaluó mediante la escala analógica visual y la función, con el puntaje de Lysholm. Resultados: Ochenta pacientes cumplían con los criterios de inclusión. Sus datos sociodemográficos fueron pareados en dos grupos similares. Treinta y seis pacientes fueron tratados con la técnica infrarrotuliana y 44, con la técnica suprarrotuliana. Se obtuvieron diferencias estadísticamente significativas en el tiempo de cirugía, el tiempo de radioscopia y en el puntaje de la escala analógica visual para dolor al año. Conclusiones: Los resultados mostraron un menor tiempo de cirugía y de radioscopia, y mejores resultados en la escala analógica visual para dolor con la técnica suprarrotuliana para el tratamiento de las fracturas mediodiafisarias y distales de tibia.
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- 2022
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21. Radon areal distribution in Campania region (Italy)inferred from a geostatistic analysis
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Sabbarese C., Barbiero D. M., D’Ambrosio P., D.’.O.n.o.f.r.i.o.A., De Cicco F., Terrasi F., PUGLIESE, MARIAGABRIELLA, ROCA, VINCENZO, Sabbarese, C., Barbiero, D. M., D’Ambrosio, P., D. ’. O. n. o. f. r. i. o., A., De Cicco, F., Pugliese, Mariagabriella, Roca, Vincenzo, and Terrasi, F.
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Radon - Published
- 2010
22. La formazione psicosociale degli operatori delle volanti della Polizia di Stato alla relazione con i cittadini come prevenzione e promozione del benessere lavorativo: specificità e prospettive
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VENZA, Gaetano, De Cicco, F., Venza, G, and De Cicco, F
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benessere lavorativo ,polizia ,formazione psicosociale - Published
- 2009
23. Track counting and thickness measurement of LR115 radon detectors using a commercial image scanner
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De Cicco, F., primary, Pugliese, M., additional, Roca, V., additional, and Sabbarese, C., additional
- Published
- 2013
- Full Text
- View/download PDF
24. Radon concentrations in schools of the Neapolitan area
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Venoso, G., De Cicco, F., Flores, B., Gialanella, L., Pugliese, M., Roca, V., and Sabbarese, C.
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- 2009
- Full Text
- View/download PDF
25. The effect of menopause on blood lipid and lipoprotein levels
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de aloysio, D, Gambacciani, M, Meschia, M, Pansini, F, Bacchi Modena, A, Bolis, Pf, Massobrio, M, Maiocchi, G, Peruzzi, E, Nencioni, T, Ciammella, M, Bonaccorsi, G, Morano, D, Viglino, S, Artoni, G, Grassini, E, Radici, G, De Cicco, F, Ronsisvalle, E, Marcacci, B, Perrone, P, De PAoli, D, Colacurci, N, De Franciscis, P, Lodico, G, Ferreri, R, Loizzi, V, Giacomelli, P, Benetello, E, Salmaggi, P, Coniglio, E, Giussani, E, Comi, R, Grimaldi, E, Mangino, Fp, Bucciantini, S, Checcucci, V, Nappi, C, Affinito, P, Campagnoli, C, Lanza, M, Galbiati, G, Albini, D, Lentini, G, Civallelci, S, Galbignani, E, Franchi, M, Terreni, Mg, Cicoli, C, Pulisca, S, Chionna, R, Marabini, R, Cordopatri, A, Spadaro, I, Cagnacci, Angelo, Volpe, A, De Leo, V, La MArca, A, Camanni, F, Manieri, C, Scognamiglio, P, Romani, L, Cargiaghe, S, Mannu, L, Masi, P, Fattorini, G, Bersellini, B, Bianicotti, L, Marchesoni, D, Dal Pozzo, M, Ramazzotto, F, Stegher, C, Molteni, B, Molteni, E, Lombardo, R, Galati, G, Sironi, A, Ranchet, G, Belloni, C, Proietti, C, Lorefice, R, Menozzi, G, Carunchio, P, Rovetta, E, Gallo, M, De Luigi, G, Righetti, G, Favaro, P, Gentile, E, Flangini, O, De Stefani, L, Sciacchitano, Sg, Catrini, R, Bartiromo, F, Bruno, M, Puggioni, Gf, Sionis, L, Agostinelli, D, Tajani, E, Mercuri, G, and Petronio, P.
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Menopause, Lipid, Cholesterol - Published
- 1999
26. Radon Exposure Assessment for Sewerage System’s Workers in Naples, South Italy
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Pugliese, M., primary, Quarto, M., additional, De Cicco, F., additional, De Sterlich, C., additional, and Roca, V., additional
- Published
- 2011
- Full Text
- View/download PDF
27. Track counting and thickness measurement of LR115 radon detectors using a commercial image scanner.
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De Cicco, F., Pugliese, M., Roca, V., and Sabbarese, C.
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RADON ,DETECTORS ,PHYSICS instruments ,COMPUTER software ,NOBLE gases - Abstract
An original optical method for track counting and film thickness determination of etched LR115 radon detectors was developed. The method offers several advantages compared with standard techniques. In particular, it is non-destructive, very simple and rather inexpensive, since it uses a commercial scanner and a free software. The complete analysis and the calibration procedure carried out for the determination of radon specific activity are reported. A comparison with the results of spark counting defines the accuracy and the precision of the new technique. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
28. Radon Exposure Assessment for Sewerage System’s Workers in Naples, South Italy.
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Pugliese, M., Quarto, M., De Cicco, F., De Sterlich, C., and Roca, V.
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SEWERAGE ,CHEMICAL ecology ,RADON ,RADON pollution - Abstract
An indoor radon survey has been carried out in 17 workplaces of sewerage system of Naples city using E-Perm detectors in long-term configuration. The main objective was to assess the mean effective dose for workers. The measured indoor radon concentration ranged from 1714 to 3789 Bq m−3 in the rooms located on second level underground, from 138 to 5772 Bq m−3 in the rooms on first level underground and from 53 to 913 Bq m−3 in the ground floor. The mean annual effective doses in the ground floor, first and second level underground were found to be 0.85 mSv, 0.29 mSv and 0.43 mSv, respectively. These values are less than the lower limit of International Commission on Radiological Protection (ICRP) recommended action levels of 3–10 mSv y−1. [ABSTRACT FROM PUBLISHER]
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- 2013
- Full Text
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29. Oxytocin receptor in human fetal membranes at term and during labor
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Benedetto, M.T., primary, De Cicco, F., additional, Rossiello, F., additional, Nicosia, A.L., additional, Lupi, G., additional, and Dell'Acqua, S., additional
- Published
- 1990
- Full Text
- View/download PDF
30. Estradiol 17β-Hydroxysteroid Dehydrogenase Activity in Human Breast Fibroadenomas
- Author
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FOURNIER, S., primary, KUTTENN, F., additional, DE CICCO, F., additional, BAUDOT, N., additional, MALET, C., additional, and MAUVAIS-JARVIS, P., additional
- Published
- 1982
- Full Text
- View/download PDF
31. In Vitro effects of β-interferon on steroid receptors and prostaglandin output in human endometrial adenocarcinoma
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De Cicco, F., primary, Sicas, G., additional, Benedetto, M.T., additional, Ciabattoni, G., additional, Rossiello, F., additional, Nicosia, A., additional, Lupi, G., additional, Iacopino, F., additional, Mancuso, S., additional, and Dell'Acqua, S., additional
- Published
- 1988
- Full Text
- View/download PDF
32. Extensor Tendons Rupture after Volar Plating of Distal Radius Fracture Related to a Dorsal Radial Metaphyseal Bone Spur
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O. Abrego, M., L. De Cicco, F., G. Boretto, J., L. Gallucci, G., and De Carli, P.
- Abstract
Extensor tendon ruptures due to volar plating in distal radius fractures have mostly been described in relation with technique failures such as screw prominence and drill penetration. We report the case of a 71-year-old female with a C2 distal radius fracture with severe dorsal metaphyseal comminution. The patient underwent surgical treatment with reduction of the large fragments and fixation with a volar locking plate; the small dorsal metaphyseal nonarticular fragments were not reduced. Six months later, the patient developed extensor digitorum communis (EDC) rupture and extensor indicis proprius (EIP) laceration in coincidence with the dorsal comminution turned into a bony spur. The possible association between the extensor tendon injury and the dorsal residual metaphyseal bony spur in the distal radius fractures is unusual but should be taken into account in fracture patterns presenting dorsal comminution.
- Published
- 2018
- Full Text
- View/download PDF
33. Talus Bipartitus: A Rare Anatomical Variant Presenting as an Entrapment Neuropathy of the Tibial Nerve within the Tarsal Tunnel
- Author
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O. Abrego, M., L. De Cicco, F., E. Gimenez, N., O. Marquesini, M., Sotelano, P., N. Carrasco, M., and G. Santini Araujo, M.
- Abstract
Tarsal tunnel syndrome is an entrapment neuropathy of the tibial nerve within the tarsal tunnel that lies beneath the retinaculum on the medial side of the ankle. It is often underdiagnosed. Talus bipartitus is a rare anatomical variant; only a few cases have been described in medical literature. We report a case of a 36-year-old female with tarsal tunnel syndrome secondary to a talus bipartitus undergoing surgical treatment with good clinical outcome. To our knowledge, talus bipartitus presenting as tarsal tunnel syndrome has no previous reports. Image studies and physical examination are crucial to reach precise diagnosis.
- Published
- 2018
- Full Text
- View/download PDF
34. From microbiota toward gastro-enteropancreatic neuroendocrine neoplasms: Are we on the highway to hell?
- Author
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Giulia Puliani, Andrea Lania, Fabio Lo Calzo, Valentina Guarnotta, Giuseppe Fanciulli, Alessandra Dicitore, Carmen Rainone, Annamaria Colao, Genoveffa Pizza, Manila Rubino, Giovanni Vitale, Severo Campione, Francesco Ferraù, Maria Chiara Zatelli, Mary Anna Venneri, Emilia Sbardella, Diego Ferone, Marco Gallo, Riccardo Pofi, Roberta Modica, Luigi Barrea, Erika Grossrubatscher, Federica Grillo, Antongiulio Faggiano, Franz Sesti, Rosa Maria Ruggieri, Barbara Altieri, Erika Messina, Luca Pes, P. Razzore, Nike, Andrea M. Isidori, Sergio Di Molfetta, Pasquale Malandrino, Andrea Lenzi, Manuela Albertelli, Tiziana Feola, Laura Rizza, Giovanna Muscogiuri, Federica de Cicco, Filomena Bottiglieri, Elia Guadagno, Elisa Giannetta, Vitale G, Dicitore A, Barrea L, Sbardella E, Razzore P, Campione S, Faggiano A, Colao A, NIKE, Albertelli M, Altieri B, Bottiglieri F, De Cicco F, Di Molfetta S, Fanciulli G, Feola T, Ferone D, Ferraù F, Gallo M, Giannetta E, Grillo F, Grossrubatscher E, Guadagno E, Guarnotta V, Isidori AM, Lania A, Lenzi A, Calzo FL, Malandrino P, Messina E, Modica R, Muscogiuri G, Pes L, Pizza G, Pofi R, Puliani G, Rainone C, Rizza L, Rubino M, Ruggieri RM, Sesti F, Venneri MA, Zatelli MC., Vitale, G., Dicitore, A., Barrea, L., Sbardella, E., Razzore, P., Campione, S., Faggiano, A., Colao, A., Albertelli, M., Altieri, B., Bottiglieri, F., De Cicco, F., Di Molfetta, S., Fanciulli, G., Feola, T., Ferone, D., Ferrau, F., Gallo, M., Giannetta, E., Grillo, F., Grossrubatscher, E., Guadagno, E., Guarnotta, V., Isidori, A. M., Lania, A., Lenzi, A., Calzo, F. L., Malandrino, P., Messina, E., Modica, R., Muscogiuri, G., Pes, L., Pizza, G., Pofi, R., Puliani, G., Rainone, C., Rizza, L., Rubino, M., Ruggieri, R. M., Sesti, F., Venneri, M. A., and Zatelli, M. C.
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Endocrinology, Diabetes and Metabolism ,Tumor microenvironment ,Biology ,Gut flora ,Neuroendocrine tumors ,medicine.disease_cause ,digestive system ,Article ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Immune system ,Neuroendocrine tumor ,Gastro ,medicine ,Humans ,Cytokine ,030304 developmental biology ,Gastrointestinal Neoplasms ,Inflammation ,0303 health sciences ,Microbiota ,digestive, oral, and skin physiology ,medicine.disease ,biology.organism_classification ,Cytokines ,Gastrointestinal Microbiome ,030220 oncology & carcinogenesis ,Immunology ,Dysbiosis ,Carcinogenesis ,Drug metabolism - Abstract
Gut microbiota is represented by different microorganisms that colonize the intestinal tract, mostly the large intestine, such as bacteria, fungi, archaea and viruses. The gut microbial balance has a key role in several functions. It modulates the host’s metabolism, maintains the gut barrier integrity, participates in the xenobiotics and drug metabolism, and acts as protection against gastro-intestinal pathogens through the host’s immune system modulation. The impaired gut microbiota, called dysbiosis, may be the result of an imbalance in this equilibrium and is linked with different diseases, including cancer. While most of the studies have focused on the association between microbiota and gastrointestinal adenocarcinomas, very little is known about gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs). In this review, we provide an overview concerning the complex interplay between gut microbiota and GEP NENs, focusing on the potential role in tumorigenesis and progression in these tumors.
- Published
- 2020
35. Lanreotide Therapy vs Active Surveillance in MEN1-Related Pancreatic Neuroendocrine Tumors2 Centimeters
- Author
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Luigi Camera, Giuseppe Badalamenti, Federica de Cicco, Franz Sesti, Annamaria Colao, Antongiulio Faggiano, Vincenzo Napolitano, Fialomena Bottiglieri, Roberta Modica, Andrea M. Isidori, Barbara Altieri, Fabio Lo Calzo, Faggiano A., Modica R., Lo Calzo F., Camera L., Napolitano V., Altieri B., De Cicco F., Bottiglieri F., Sesti F., Badalamenti G., Isidori A.M., Colao A., Faggiano, A, Modica, R., Lo Calzo, F., Camera, L., Napolitano, V., Altieri, B., De Cicco, F, Bottiglieri, F., Sesti, F., Badalamenti, G., Isidori, A. M., and Colao, A.
- Subjects
Male ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Neuroendocrine tumors ,Lanreotide ,Biochemistry ,Gastroenterology ,chemistry.chemical_compound ,Endocrinology ,active surveillance, lanreotide, MEN1, pancreatic neuroendocrine tumors, somatostatin analogues ,Prospective Studies ,Prospective cohort study ,Multiple endocrine neoplasia ,somatostatin analogues ,Middle Aged ,Prognosis ,Tumor Burden ,Neuroendocrine Tumors ,Somatostatin ,MEN1 ,Disease Progression ,Female ,lanreotide ,Adult ,medicine.medical_specialty ,Antineoplastic Agents ,pancreatic neuroendocrine tumor ,Peptides, Cyclic ,Young Adult ,Internal medicine ,medicine ,Multiple Endocrine Neoplasia Type 1 ,Humans ,Watchful Waiting ,Aged ,Centimeter ,pancreatic neuroendocrine tumors ,business.industry ,Biochemistry (medical) ,active surveillance ,medicine.disease ,Pancreatic Neoplasms ,chemistry ,Tumor progression ,Case-Control Studies ,business ,Follow-Up Studies - Abstract
Purpose Pancreatic neuroendocrine tumors (pNETs) are frequent in multiple endocrine neoplasia type 1 (MEN1) syndrome. They are usually not surgically treated unless larger than 1 to 2 cm or a growth rate > 0.5 cm per year. Somatostatin analogues represent one of the main therapeutic options in pNETs, but they have never been prospectively investigated in MEN1-related pNETs. The aim of this study was to prospectively evaluate the effectiveness of lanreotide in patients with MEN1-related pNETs < 2 cm. Methods MEN1 patients with 1 or more pNETs < 2 cm of maximal diameter were considered. Study design was prospective observational, comparing patients treated with lanreotide autogel 120 mg every 28 days (LAN group) and patients in active surveillance, not receiving any therapy (AS group). Results Forty-two patients were enrolled: 23 in LAN and 19 in AS group. Median follow-up was 73 months. Initial imaging identified a total of 91 pNETs. The median progression-free survival was significantly longer in the LAN than in the AS group (median not reached vs 40 months, P < 0.001). In the LAN group, 4 patients had an objective tumor response, 15 patients had stable disease, while 4 had tumor progression. In the AS group, 13 patients had pNET progression, while 6 were stable. Conclusions This is the first prospective study evaluating the efficacy of somatostatin analogues in MEN1-related pNETs. These findings highlight that lanreotide autogel is effective as antiproliferative therapy in MEN1-related pNETs < 2cm, suggesting the utility of somatostatin analogues to arrest the development of tumor lesions as well as to delay or avoid pancreatic surgery.
- Published
- 2019
36. Vitamin D deficiency and tumor aggressiveness in gastroenteropancreatic neuroendocrine tumors
- Author
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Roberta Modica, Carolina Di Somma, Antongiulio Faggiano, Giovanna Muscogiuri, Luigi Barrea, Luisa Circelli, Filomena Bottiglieri, Barbara Altieri, Silvia Savastano, Annamaria Colao, Giovanni Savarese, Federica de Cicco, Altieri, B., Barrea, L., Modica, R., Bottiglieri, F., de Cicco, F., Muscogiuri, G., Circelli, L., Savarese, G., Di Somma, C., Savastano, S., Colao, A., and Faggiano, A.
- Subjects
Intestinal Neoplasm ,medicine.medical_specialty ,Prognosi ,Endocrinology, Diabetes and Metabolism ,Neuroendocrine tumors ,Gastroenterology ,vitamin D deficiency ,Somatostatin analog ,Endocrinology ,Neuroendocrine tumor ,Retrospective Studie ,Stomach Neoplasm ,Stomach Neoplasms ,Diabetes mellitus ,Internal medicine ,Intestinal Neoplasms ,medicine ,Vitamin D and neurology ,Humans ,Vitamin D ,Retrospective Studies ,Cross-Sectional Studie ,25(OH)D ,business.industry ,Incidence (epidemiology) ,Pancreatic Neoplasm ,Vitamin D Deficiency ,medicine.disease ,Primary tumor ,Pancreatic Neoplasms ,Neuroendocrine Tumors ,MEN1 ,Cross-Sectional Studies ,business ,Body mass index ,Progressive disease ,PTH ,Human - Abstract
Purpose: Data regarding vitamin D status in patients affected by gastroenteropancreatic (GEP) neuroendocrine tumor (NET) are limited and often showing contrasting results. The aim of the study was to evaluate the incidence of vitamin D deficiency (
- Published
- 2021
37. SIGNAL DECOMPOSITION AND ANALYSIS FOR THE IDENTIFICATION OF PERIODIC AND ANOMALOUS PHENOMENA IN RADON TIME-SERIES
- Author
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F. De Cicco, Carlo Sabbarese, F. Ambrosino, Vincenzo Roca, Mariagabriella Pugliese, Maria Quarto, Sabbarese, C., Ambrosino, F., De Cicco, F., Pugliese, M., Quarto, M., Roca, V., Sabbarese, Carlo, Ambrosino, Fabrizio, DE CICCO, Filomena, Pugliese, Mariagabriella, Quarto, Maria, and Roca, Vincenzo
- Subjects
chemistry.chemical_element ,Soil science ,Radon ,010403 inorganic & nuclear chemistry ,01 natural sciences ,Measure (mathematics) ,Signal ,Hilbert–Huang transform ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Radiation Monitoring ,Radon, soil gas, Earthquake Precursor ,Linear regression ,Soil Pollutants, Radioactive ,Radiology, Nuclear Medicine and imaging ,Interrupted Time Series Analysi ,Weather ,Radiation ,Radiological and Ultrasound Technology ,Soil gas ,Continuous monitoring ,Public Health, Environmental and Occupational Health ,Interrupted Time Series Analysis ,General Medicine ,0104 chemical sciences ,chemistry ,Italy ,Environmental science ,Season ,Seasons ,Intensity (heat transfer) - Abstract
This work concerns continuous monitoring of radon and thoron specific activity in soil gas within the framework of identifying possible anomalies. It is based on the analysis of a medium-term data record obtained from soil gas in an area of geophysical interest. The RaMonA spectrometric system is also used to measure the climatic parameters and a specific analysis of the alpha spectra is performed to better determine the alpha lines intensity. Since radon emission is also influenced by meteorological parameters, it is mandatory to differentiate the changes due to the deep phenomena. Different procedures are utilized to reach the above objective: statistical analysis using the Empirical Mode Decomposition technique, the Multiple Linear Regression method and the Remote Radon Estimation by using of the thoron trend to eliminate the locally produced radon fraction. The results of such methods are compared to recognize and to highlight radon anomalies. © The Author 2017. Published by Oxford University Press. All rights reserved.
- Published
- 2017
38. Multi-parametric approach to the analysis of soil radon gas for its validation as geoindicator in two sites of the Phlegrean Fields caldera (Italy)
- Author
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W. De Cesare, I. Aquino, F. De Cicco, Mariagabriella Pugliese, Carlo Sabbarese, Vincenzo Roca, Maria Quarto, F. Savino, DE CICCO, Filomena, Pugliese, Mariagabriella, Quarto, Maria, Roca, Vincenzo, Sabbarese, Carlo, Savino, F., Aquino, I., De Cesare, W., De Cicco, F., Pugliese, M., Quarto, M., Roca, V., and Sabbarese, C.
- Subjects
Radon continuous monitoring Multi-parametric analysis Radon as geoindicator Phlegrean Fields caldera ,Soil Science ,chemistry.chemical_element ,Radon ,Soil science ,010502 geochemistry & geophysics ,010403 inorganic & nuclear chemistry ,01 natural sciences ,Linear regression ,Environmental Chemistry ,Caldera ,Relative humidity ,0105 earth and related environmental sciences ,Earth-Surface Processes ,Water Science and Technology ,Global and Planetary Change ,Multi parametric ,Soil gas ,Geology ,Radon gas ,Crust ,Pollution ,0104 chemical sciences ,chemistry ,Seismology - Abstract
Radon is considered one of the short- and immediate-term earthquake precursors by International Association of Seismology and Physics of the Earth’s Interior. For this reason, the accurate and reliable measurement of its specific activity in soil gas is mandatory. Since its presence is influenced by many environmental factors, in order to eliminate this influence on the radon activity measurement a multi-parametric and multi-site analysis is necessary. Following this approach, a continuous radon monitoring was carried out in two sites of the Phlegrean Fields caldera (Campania, Italy) using the RaMonA system, which also allows for the measurement of temperature, relative humidity and pressure. In particular, the dependence of measured radon specific activity on the meteorological conditions was studied using the multiple linear regression method. The analysis was implemented also by testing data averages on different timescales. In this paper, the results of a preliminary analysis performed on data collected throughout 2012 are presented; the outcomes obtained allow to emphasize site-specific behavior and to discriminate apparent radon “anomalies” of climatic origin from those tied to the phenomena occurring in the earth’s crust. The method employed showed its usefulness by removing the effects of meteorological conditions and thus to better identify the possible radon anomalies caused by seismo-volcanic activity. The peculiarities of the different sites and some correlations with earthquakes are discussed.
- Published
- 2017
39. Dependence of the LR-115 radon detector calibration factor on track density
- Author
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Vincenzo Roca, Mariagabriella Pugliese, F. De Cicco, Carlo Sabbarese, F., De Cicco, Pugliese, Mariagabriella, Roca, Vincenzo, C., Sabbarese, De Cicco, F, Pugliese, M, Roca, V, and Sabbarese, Carlo
- Subjects
Radiation ,Materials science ,Computer simulation ,Detector calibration ,Analytical chemistry ,Reproducibility of Results ,chemistry.chemical_element ,Radon ,Equipment Design ,Radiation Dosage ,Sensitivity and Specificity ,Track density ,Computational physics ,Radon exposure ,Exponential function ,Equipment Failure Analysis ,chemistry ,Air Pollutants, Radioactive ,Calibration ,Track detectors ,Artifacts ,Radiometry ,Saturation (chemistry) - Abstract
The reliability and accuracy of the methodology based on using LR-115 track detectors for radon measurements have been studied by determining the dependence of their calibration factors on radon exposure at levels reaching 13 MBq m−3 h. This factor results not constant and demonstrated a decreasing exponential trend vs. exposure that has been explained in terms of the saturation effect and verified using a numerical simulation. This dependence does not affect the parameter that normalizes track density vs. film thickness. This parameter results constant and equal to - 0.30±0.02 cm−2/µm in the 300–8000 kBq h m−3 exposure range.
- Published
- 2013
40. TRACKCOUNTING AND THICKNESS MEASUREMENTOF LR115 RADON DETECTORS USING ACOMMERCIAL IMAGE SCANNER
- Author
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F. De Cicco, Carlo Sabbarese, V. Roca, Mariagabriella Pugliese, F., De Cicco, Pugliese, Mariagabriella, Roca, Vincenzo, C., Sabbarese, De Cicco, F., Pugliese, M., Roca, V., and Sabbarese, C.
- Subjects
Scanner ,Computer science ,chemistry.chemical_element ,Image processing ,Radon ,Software ,Optics ,Radiation Monitoring ,Spark (mathematics) ,Calibration ,Image Processing, Computer-Assisted ,Radiology, Nuclear Medicine and imaging ,Radiation ,Radiological and Ultrasound Technology ,business.industry ,Track (disk drive) ,Detector ,Public Health, Environmental and Occupational Health ,optical analysis ,radon ,General Medicine ,chemistry ,Air Pollutants, Radioactive ,SSNTD detector ,Nuclear medicine ,business - Abstract
An original optical method for track counting and film thickness determination of etched LR115 radon detectors was developed. The method offers several advantages compared with standard techniques. In particular, it is non-destructive, very simple and rather inexpensive, since it uses a commercial scanner and a free software. The complete analysis and the calibration procedure carried out for the determination of radon specific activity are reported. A comparison with the results of spark counting defines the accuracy and the precision of the new technique.
- Published
- 2013
41. Evaluation of the in vitro and in vivo antiangiogenic effects of denosumab and zoledronic acid
- Author
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Gabriella, Misso, Manuela, Porru, Stoppacciaro, Antonella, Maria, Castellano, Federica De Cicco, Carlo, Leonetti, Daniele, Santini, Michele, Caraglia, Santini, Daniele, Misso, Gabriella, Porru, M, Stoppacciaro, A, Castellano, M, De Cicco, F, Leonetti, C, Santini, D, and Caraglia, Michele
- Subjects
Pathology ,Cancer Research ,Angiogenesis ,Angiogenesis Inhibitors ,Humanized antibody ,Neovascularization ,Mice ,zoledronic acid ,angiogenesis ,huvec ,Mice, Inbred BALB C ,biology ,Bone Density Conservation Agents ,Diphosphonates ,Neovascularization, Pathologic ,Imidazoles ,denosumab ,breast cancer ,acid 10.4161/cbt.22274 ,anticancer ,rankl ,zoledronic ,Angiogenesi ,Denosumab ,Diphosphonate ,Oncology ,RANKL ,Molecular Medicine ,Female ,medicine.symptom ,Breast Neoplasm ,medicine.drug ,Angiogenesis Inhibitor ,Human ,Research Paper ,medicine.medical_specialty ,Bone Density Conservation Agent ,Xenograft Model Antitumor Assay ,Cell Survival ,Human Umbilical Vein Endothelial Cell ,Mice, Nude ,Bone Neoplasms ,Breast Neoplasms ,Bone Neoplasm ,Antibodies, Monoclonal, Humanized ,In vivo ,Cell Line, Tumor ,medicine ,Human Umbilical Vein Endothelial Cells ,Animals ,Humans ,Imidazole ,Pharmacology ,Matrigel ,business.industry ,Animal ,RANK Ligand ,Xenograft Model Antitumor Assays ,In vitro ,Cancer research ,biology.protein ,business ,Neoplasm Transplantation - Abstract
""Denosumab (Dmab) and zoledronic acid (ZOL) are antiresorptive agents, with different mechanisms of action, that are indicated for delaying the onset of skeletal-related events in patients with bone metastases from solid tumors. Clinical and preclinical data suggest that ZOL may have also anti-angiogenic activity; however, the effects of Dmab (a fully humanized antibody against the receptor activator of nuclear factor kappa B ligand) on angiogenesis are largely unknown. The objective of this study was to compare the potential anti-angiogenic activity of Dmab with that of ZOL in preclinical models. Dmab (0.31 to 160 µM) had no effect on the viability of human MDA-MB-436 and CG5 breast cancer cells or human umbilical vein endothelial cells (HUVECs) and no effect on tubule formation or invasion of HUVECs. In contrast, ZOL (0.31 to 160 µM) decreased the viability of breast cancer and HUVECs in a time- and concentration-dependent manner, and also inhibited HUVEC tubule formation and invasion. In vivo, ZOL (100 µg\\\/kg s.c. twice weekly for 6 weeks) inhibited angiogenesis in Matrigel plugs and inhibited the growth and neo-angiogenesis of CG5 xenografts in athymic nude mice. In contrast, Dmab (100 µg\\\/kg s.c. twice weekly for 6 weeks) had no effect on Matrigel vascularization or xenograft growth in this model. These findings support the potential antiangiogenic and anticancer activity of ZOL in vitro and in vivo, and further suggest that Dmab does not have antiangiogenic activity. Additional studies are needed to elucidate the potential anticancer activity of Dmab."" Denosumab (Dmab) and zoledronic acid (ZOL) are antiresorptive agents, with different mechanisms of action, that are indicated for delaying the onset of skeletal-related events in patients with bone metastases from solid tumors. Clinical and preclinical data suggest that ZOL may have also anti-angiogenic activity; however, the effects of Dmab (a fully humanized antibody against the receptor activator of nuclear factor kappa B ligand) on angiogenesis are largely unknown. The objective of this study was to compare the potential anti-angiogenic activity of Dmab with that of ZOL in preclinical models. Dmab (0.31 to 160 μM) had no effect on the viability of human MDA-MB-436 and CG5 breast cancer cells or human umbilical vein endothelial cells (HUVECs) and no effect on tubule formation or invasion of HUVECs. In contrast, ZOL (0.31 to 160 μM) decreased the viability of breast cancer and HUVECs in a time- and concentration-dependent manner and also inhibited HUVEC tubule formation and invasion. In vivo, ZOL (20 μg/mouse three times a week for three consecutive weeks) inhibited angiogenesis in Matrigel plugs and inhibited the growth and neo-angiogenesis of CG5 xenografts in athymic nude mice. In contrast, Dmab (10 mg/kg twice a week for four consecutive weeks) had no effect on Matrigel vascularization or xenograft growth in this model. These findings support the potential antiangiogenic and anticancer activity of ZOL in vitro and in vivo and further suggest that Dmab does not have antiangiogenic activity. Additional studies are needed to elucidate the potential anticancer activity of Dmab. © 2012 Landes Bioscience.
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- 2012
42. Radon concentrations in schools of the neapolitan area
- Author
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Lucio Gialanella, B. Flores, Vincenzo Roca, F. De Cicco, G. Venoso, Mariagabriella Pugliese, Carlo Sabbarese, G., Venoso, F., De Cicco, B., Flore, L., Gialanella, Pugliese, Mariagabriella, Roca, Vincenzo, C., Sabbarese, Venoso, G, De Cicco, F, Flores, B, Gialanella, Lucio, Pugliese, M, Roca, V, and Sabbarese, Carlo
- Subjects
Radiation ,chemistry ,Nuclear track ,Solid-state ,Environmental science ,chemistry.chemical_element ,Mineralogy ,Radon ,Instrumentation ,Metropolitan area - Abstract
A radon survey was carried out in 30 schools located in the metropolitan area around Naples, Italy. Radonconcentration was measured using the SSNTD (Solid State Nuclear Track Detectors) method with LR115 detectors. Time integrated measurements covered two consecutive 6-month periods at different locations inside the school buildings: classrooms, laboratories and offices. Data distribution is well fitted by a log-normal curve. The arithmetic mean annual radonconcentration is 144 Bq m−3, the geometric mean is 86 Bq m−3; the standard deviations are respectively 7 Bq m−3 and 3. The fractions of rooms where radonconcentrations exceed the reference levels of 200, 400 and 500 Bq m−3 are 21.3%, 7.6% and 4.5% respectively. The results show that radonconcentration in scientific laboratories and in offices is higher than in classrooms.
- Published
- 2009
43. Multiple endocrine neoplasia type 4 (MEN4): a thorough update on the latest and least known men syndrome.
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Ruggeri RM, Benevento E, De Cicco F, Grossrubatscher EM, Hasballa I, Tarsitano MG, Centello R, Isidori AM, Colao A, Pellegata NS, and Faggiano A
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- Humans, Syndrome, Multiple Endocrine Neoplasia diagnosis, Multiple Endocrine Neoplasia genetics, Multiple Endocrine Neoplasia pathology, Multiple Endocrine Neoplasia Type 1 genetics, Multiple Endocrine Neoplasia Type 1 diagnosis, Neuroendocrine Tumors genetics, Adenoma genetics
- Abstract
Purpose: Multiple endocrine neoplasia type 4 (MEN4) is a rare multiglandular endocrine neoplasia syndrome, associated with a wide tumor spectrum but hallmarked by primary hyperparathyroidism, which represents the most common clinical feature, followed by pituitary (functional and non-functional) adenomas, and neuroendocrine tumors. MEN4 clinically overlaps MEN type 1 (MEN1) but differs from it for milder clinical features and an older patient's age at onset. The underlying mutated gene, CDKN1B, encodes the cell cycle regulator p27, implicated in cellular proliferation, motility and apoptosis. Given the paucity of MEN4 cases described in the literature, possible genotype-phenotype correlations have not been thoroughly assessed, and specific clinical recommendations are lacking. The present review provides an extensive overview of molecular genetics and clinical features of MEN4, with the aim of contributing to delineate peculiar strategies for clinical management, screening and follow-up of the last and least known MEN syndrome., Methods: A literature search was performed through online databases like MEDLINE and Scopus., Conclusions: MEN4 is much less common that MEN1, tend to present later in life with a more indolent course, although involving the same primary organs as MEN1. As a consequence, MEN4 patients might need specific diagnostic and therapeutic approaches and a different strategy for screening and follow-up. Further studies are needed to assess the real oncological risk of MEN4 carriers, and to establish a standardized screening protocol. Furthermore, a deeper understanding of molecular genetics of MEN4 is needed in order to explore p27 as a novel therapeutic target., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2023
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44. 30 Days Mortality Prognostic Value of POCT Bio-Adrenomedullin and Proenkephalin in Patients with Sepsis in the Emergency Department.
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Casalboni S, Valli G, Terlizzi F, Mastracchi M, Fidelio G, De Marco F, Bernardi C, Chieruzzi A, Curcio A, De Cicco F, Colella N, Papasidero ID, Tartarone E, Ruggieri MP, and Di Somma S
- Subjects
- Adult, Humans, Prognosis, Point-of-Care Systems, Biomarkers, Emergency Service, Hospital, Hospital Mortality, Adrenomedullin, Sepsis
- Abstract
Background and Objective: Sepsis is a worldwide severe disease with a high incidence and mortality rate. Sepsis is a frequent cause of admission to the emergency department (ED). Although prognostic scores (Sequential Organ Failure Assessment, SOFA; New Early Warning Score, NEWS; Rapid Emergency Medicine Score, REMS) are commonly used for risk stratification in septic patients, many of these scores are of poor utility in the ED. In this setting, biomarkers are promising alternatives, easier to perform and potentially more specific. Bio-adrenomedullin (Bio-ADM) and Proenkephalin (PenKid) seem to have a key role in the development of organ dysfunctions induced by sepsis and, therefore, could help in the risk stratification of patients with sepsis at ED admission. The aim of this study was to evaluate the utility of Bio-ADM and PenKid, obtained through a point of care (POCT) device, in predicting 30 days mortality for patients presenting to the ED with sepsis. Methods and Results: In total, 177 consecutive adult patients with a diagnosis of sepsis presenting to the ED of San Giovanni Addolorata Hospital in Rome, Italy, between May 2021 and April 2022 were enrolled in this prospective observational study. For each patient, Bio-ADM and PenKid were obtained at ED admission together with SOFA, NEWS and REMS scores. Next, 30 days follow-up data were collected to evaluate patient mortality. Both biomarkers (Bio-ADM and PenKid) and clinical scores (SOFA, NEWS and REMS) were good predictors of mortality at 30 days, with Bio-ADM and REMS outperforming the others. Moreover, PenKid resulted in being linked with the worsening of kidney function. Conclusions: In patients presenting with sepsis in the ED, Bio-ADM and PenKid, evaluated with a POCT device, predicted 30-day mortality. These two biomarkers seem even more useful when integrated with clinical risk scores at ED admission.
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- 2022
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45. Vitamin D deficiency and tumor aggressiveness in gastroenteropancreatic neuroendocrine tumors.
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Altieri B, Barrea L, Modica R, Bottiglieri F, de Cicco F, Muscogiuri G, Circelli L, Savarese G, Di Somma C, Savastano S, Colao A, and Faggiano A
- Subjects
- Cross-Sectional Studies, Humans, Intestinal Neoplasms, Retrospective Studies, Stomach Neoplasms, Vitamin D, Neuroendocrine Tumors pathology, Pancreatic Neoplasms complications, Pancreatic Neoplasms epidemiology, Vitamin D Deficiency complications, Vitamin D Deficiency epidemiology
- Abstract
Purpose: Data regarding vitamin D status in patients affected by gastroenteropancreatic (GEP) neuroendocrine tumor (NET) are limited and often showing contrasting results. The aim of the study was to evaluate the incidence of vitamin D deficiency (<20 ng/mL) in GEP-NET patients and compare the 25-hydroxyvitamin D (25(OH)D) levels with clinicopathological parameters and clinical outcome., Methods: A retrospective cross-sectional study including 75 low grade (G1-G2) GEP-NETs and 123 healthy controls matched for age, sex, and body mass index, was performed., Results: GEP-NET patients had significantly lower 25(OH)D levels compared to controls (17.9 ± 7.8 vs 24.2 ± 7.7 ng/mL, p < 0.0001). Ileal NETs were associated to lower 25(OH)D levels compared to other primary tumor sites (p = 0.049) and small bowel resection posed a significant increased risk of severe vitamin D deficiency (OR = 2.81, 95% CI = 1.25-3.37, p = 0.018). No correlation with somatostatin analogs treatment was found. 25(OH)D levels were significantly lower in G2 compared to G1 GEP-NETs (15.6 ± 7.8 vs 19.9 ± 7.4 ng/mL, p = 0.016) and in patients with progressive disease (12.6 ± 5.7 ng/mL) compared to those with stable disease (mean 21.5 ± 8.2 ng/mL, p = 0.001) or tumor free after surgery (19.6 ± 7.3 ng/mL, p = 0.002). Patients with vitamin D deficiency and insufficiency had shorter progression-free survival compared to those with sufficiency (p = 0.014), whereas no correlation was found with disease-specific survival., Conclusions: Vitamin D deficiency is highly prevalent among GEP-NETs and could be associated with high tumor grade and disease progression. Therefore, the monitoring of 25(OH)D levels is relevant in these patients and vitamin D supplementation should be considered in the management of GEP-NET patients with vitamin D deficiency or insufficiency., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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46. [Intra-articular fracture of the calcaneus associated with injury to lateral collateral ligaments of the ankle].
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Sánchez-Saba JE, De-Cicco FL, Abrego MO, Llano L, Carabelli-Guido S, Barla JD, Sancineto CF, and Taype-Zamboni DRE
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- Adult, Ankle, Ankle Joint surgery, Fracture Fixation, Internal, Humans, Male, Treatment Outcome, Young Adult, Ankle Injuries complications, Ankle Injuries surgery, Calcaneus injuries, Fractures, Bone complications, Fractures, Bone surgery, Intra-Articular Fractures, Lateral Ligament, Ankle injuries, Lateral Ligament, Ankle surgery
- Abstract
Calcaneal fractures are the most frequent of the tarsus (3.5% of all fractures). Young adults are mainly affected, being more frequent in men (5.9:1). On the other hand, ligament injuries associated with fracture of the calcaneus are very infrequent. We describe a case of a 39 year old patient who suffered ankle trauma. He presented instability in plantar flexion and inversion. A fracture of the calcaneus was diagnosed. During surgery, a complete lesion of the lateral ligament complex was found. The reduction and osteosynthesis associated with ligament reconstruction was performed. We consider important to confirm the stability of the ankle after a calcaneus fracture. Lack of diagnosis in this type of injuries can evolve into chronic instability.
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- 2021
47. From microbiota toward gastro-enteropancreatic neuroendocrine neoplasms: Are we on the highway to hell?
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Vitale G, Dicitore A, Barrea L, Sbardella E, Razzore P, Campione S, Faggiano A, Colao A, Albertelli M, Altieri B, Bottiglieri F, De Cicco F, Di Molfetta S, Fanciulli G, Feola T, Ferone D, Ferraù F, Gallo M, Giannetta E, Grillo F, Grossrubatscher E, Guadagno E, Guarnotta V, Isidori AM, Lania A, Lenzi A, Calzo FL, Malandrino P, Messina E, Modica R, Muscogiuri G, Pes L, Pizza G, Pofi R, Puliani G, Rainone C, Rizza L, Rubino M, Ruggieri RM, Sesti F, Venneri MA, and Zatelli MC
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- Dysbiosis, Humans, Gastrointestinal Microbiome, Gastrointestinal Neoplasms, Microbiota, Neuroendocrine Tumors
- Abstract
Gut microbiota is represented by different microorganisms that colonize the intestinal tract, mostly the large intestine, such as bacteria, fungi, archaea and viruses. The gut microbial balance has a key role in several functions. It modulates the host's metabolism, maintains the gut barrier integrity, participates in the xenobiotics and drug metabolism, and acts as protection against gastro-intestinal pathogens through the host's immune system modulation. The impaired gut microbiota, called dysbiosis, may be the result of an imbalance in this equilibrium and is linked with different diseases, including cancer. While most of the studies have focused on the association between microbiota and gastrointestinal adenocarcinomas, very little is known about gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs). In this review, we provide an overview concerning the complex interplay between gut microbiota and GEP NENs, focusing on the potential role in tumorigenesis and progression in these tumors., (© 2020. The Author(s).)
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- 2021
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48. Quality of Life in Patients with Neuroendocrine Neoplasms: The Role of Severity, Clinical Heterogeneity, and Resilience.
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Scandurra C, Modica R, Maldonato NM, Dolce P, Dipietrangelo GG, Centello R, Di Vito V, Bottiglieri F, de Cicco F, Giannetta E, Isidori AM, Lenzi A, Muzii B, Faggiano A, and Colao A
- Subjects
- Adult, Aged, Biological Variation, Population physiology, Cross-Sectional Studies, Female, Humans, Italy epidemiology, Male, Middle Aged, Psychosocial Functioning, Severity of Illness Index, Social Interaction, Young Adult, Neuroendocrine Tumors epidemiology, Neuroendocrine Tumors pathology, Neuroendocrine Tumors psychology, Neuroendocrine Tumors therapy, Quality of Life, Resilience, Psychological
- Abstract
Context: Although health-related quality of life (HRQoL) is a fundamental outcome in oncological clinical trials, its evaluation in the neuroendocrine neoplasm (NEN) research field is still limited., Objectives: This study assessed the role of clinical severity (ie, presence or absence of metastasis and lines of therapies) and heterogeneity (ie, primary site, types of therapy, biology, and surgery) of NEN in relation to HRQoL, as well as resilience as a moderator between clinical severity and HRQoL., Design: Cross-sectional multicentric study., Setting: Italian university hospitals., Patients: A total of 99 Italian patients (53 men and 46 women) with NEN and ranged in age from 22-79 years old., Main Outcome Measure: Severity and heterogeneity of NENs, HRQoL, and resilience., Results: The presence of metastasis and a greater number of therapies affected the global health and some physical symptoms. Resilience was associated with global health, functional status, and some physical symptoms, and it moderated the impact of metastases on constipation and of the multiple therapies on diarrhea and financial problems. Patients with NEN in districts other than the gastroenteropancreatic system and those in follow-up perceived fewer physical symptoms than their counterparts. Patients with a sporadic NEN perceived their functional status, global health, and disease-related worries as better than those with a hereditary NEN. Patients who underwent surgery were lower in constipation than their counterparts., Conclusion: These findings highlight the need to assess the relationships between the clinical severity and heterogeneity of NEN with HRQoL and the role of resilience in improving patients' HRQoL., (© The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2021
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49. Arthroscopic Acute Bony Bankart Repair in Lateral Decubitus.
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Atala NA, Bongiovanni S, Rossi LA, De Cicco F, Bruchmann MG, Tanoira I, and Ranalletta M
- Abstract
The optimal management of anterior shoulder instability continues to be a challenge. The presence of an anterior glenoid rim fracture in the context of a glenohumeral dislocation, also called "bony Bankart lesion," can alter therapeutic behavior. Reduction and fixation of the bone fragment has been shown to greatly reduce the risk of recurrence once bone consolidation is achieved. However, there is no gold standard surgical technique. Stability of fixation and the healing of the bony fragment are still a concern, and there are no clinical studies comparing the different techniques to date. The aim of this report is to describe an arthroscopic double-point fragment fixation technique in lateral decubitus for the treatment of an acute traumatic shoulder dislocation with a bony Bankart lesion., (© 2020 by the Arthroscopy Association of North America. Published by Elsevier.)
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- 2020
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50. Advances in the Management of Medullary Thyroid Carcinoma: Focus on Peptide Receptor Radionuclide Therapy.
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Grossrubatscher E, Fanciulli G, Pes L, Sesti F, Dolci C, de Cicco F, Colao A, Faggiano A, and Nike Group
- Abstract
Effective treatment options in advanced/progressive/metastatic medullary thyroid carcinoma (MTC) are currently limited. As in other neuroendocrine neoplasms (NENs), peptide receptor radionuclide therapy (PRRT) has been used as a therapeutic option in MTC. To date, however, there are no published reviews dealing with PRRT approaches. We performed an in-depth narrative review on the studies published in this field and collected information on registered clinical trials related to this topic. We identified 19 published studies, collectively involving more than 200 patients with MTC, and four registered clinical trials. Most cases of MTC were treated with PRRT with somatostatin analogues (SSAs) radiolabelled with 90 yttrium (90Y) and 177 lutetium (177Lu). These radiopharmaceuticals show efficacy in the treatment of patients with MTC, with a favourable radiological response (stable disease, partial response or complete response) in more than 60% of cases, coupled with low toxicity. As MTC specifically also expresses cholecystokinin receptors (CCK2Rs), PRRT with this target has also been tried, and some randomised trials are ongoing. Overall, PRRT seems to have an effective role and might be considered in the therapeutic strategy of advanced/progressive/metastatic MTC.
- Published
- 2020
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