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From microbiota toward gastro-enteropancreatic neuroendocrine neoplasms: Are we on the highway to hell?
- Source :
- Reviews in Endocrine & Metabolic Disorders
- Publication Year :
- 2020
-
Abstract
- Gut microbiota is represented by different microorganisms that colonize the intestinal tract, mostly the large intestine, such as bacteria, fungi, archaea and viruses. The gut microbial balance has a key role in several functions. It modulates the host’s metabolism, maintains the gut barrier integrity, participates in the xenobiotics and drug metabolism, and acts as protection against gastro-intestinal pathogens through the host’s immune system modulation. The impaired gut microbiota, called dysbiosis, may be the result of an imbalance in this equilibrium and is linked with different diseases, including cancer. While most of the studies have focused on the association between microbiota and gastrointestinal adenocarcinomas, very little is known about gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs). In this review, we provide an overview concerning the complex interplay between gut microbiota and GEP NENs, focusing on the potential role in tumorigenesis and progression in these tumors.
- Subjects :
- Endocrinology, Diabetes and Metabolism
Tumor microenvironment
Biology
Gut flora
Neuroendocrine tumors
medicine.disease_cause
digestive system
Article
03 medical and health sciences
0302 clinical medicine
Endocrinology
Immune system
Neuroendocrine tumor
Gastro
medicine
Humans
Cytokine
030304 developmental biology
Gastrointestinal Neoplasms
Inflammation
0303 health sciences
Microbiota
digestive, oral, and skin physiology
medicine.disease
biology.organism_classification
Cytokines
Gastrointestinal Microbiome
030220 oncology & carcinogenesis
Immunology
Dysbiosis
Carcinogenesis
Drug metabolism
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Reviews in Endocrine & Metabolic Disorders
- Accession number :
- edsair.doi.dedup.....6c082ec496ab7249d8b3e11290111893