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2. Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR).

Author

Mishra, Nishant, Kwan, Patrick, Tanaka, Tomotaka, Sunnerhagen, Katharina, Dawson, Jesse, Zhao, Yize, Misra, Shubham, Wang, Selena, Sharma, Vijay, Mazumder, Rajarshi, Funaro, Melissa, Ihara, Masafumi, Nicolo, John-Paul, Liebeskind, David, Yasuda, Clarissa, Cendes, Fernando, Quinn, Terence, Ge, Zongyuan, Scalzo, Fabien, Zelano, Johan, and Kasner, Scott

Subjects
Epilepsy, Patient Reported Outcome Measures, Prognosis, Stroke, Systematic Review, Humans, Adolescent, Adult, Epilepsy, Seizures, Prognosis, Research Design, Stroke, Meta-Analysis as Topic
Abstract

INTRODUCTION: Despite significant advances in managing acute stroke and reducing stroke mortality, preventing complications like post-stroke epilepsy (PSE) has seen limited progress. PSE research has been scattered worldwide with varying methodologies and data reporting. To address this, we established the International Post-stroke Epilepsy Research Consortium (IPSERC) to integrate global PSE research efforts. This protocol outlines an individual patient data meta-analysis (IPD-MA) to determine outcomes in patients with post-stroke seizures (PSS) and develop/validate PSE prediction models, comparing them with existing models. This protocol informs about creating the International Post-stroke Epilepsy Research Repository (IPSERR) to support future collaborative research. METHODS AND ANALYSIS: We utilised a comprehensive search strategy and searched MEDLINE, Embase, PsycInfo, Cochrane, and Web of Science databases until 30 January 2023. We extracted observational studies of stroke patients aged ≥18 years, presenting early or late PSS with data on patient outcome measures, and conducted the risk of bias assessment. We did not apply any restriction based on the date or language of publication. We will invite these study authors and the IPSERC collaborators to contribute IPD to IPSERR. We will review the IPD lodged within IPSERR to identify patients who developed epileptic seizures and those who did not. We will merge the IPD files of individual data and standardise the variables where possible for consistency. We will conduct an IPD-MA to estimate the prognostic value of clinical characteristics in predicting PSE. ETHICS AND DISSEMINATION: Ethics approval is not required for this study. The results will be published in peer-reviewed journals. This study will contribute to IPSERR, which will be available to researchers for future PSE research projects. It will also serve as a platform to anchor future clinical trials. TRIAL REGISTRATION NUMBER: NCT06108102.

Published
2023

4. Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST

Author

MACDONALD, Alexander S., MCCONNACHIE, Alex, DICKIE, David Alexander, BATH, Philip M., FORBES, Kirsten, QUINN, Terence, BROOMFIELD, Niall M., DANI, Krishna, DONEY, Alex, MUIR, Keith W., STRUTHERS, Allan, WALTERS, Matthew, BARBER, Mark, BHALLA, Ajay, CAMERON, Alan, GUYLER, Paul, HASSAN, Ahamad, KEARNEY, Mark, KEEGAN, Breffni, LAKSHMANAN, Sekaran, MACLEOD, Mary Joan, RANDALL, Marc, SHAW, Louise, SUBRAMANIAN, Ganesh, WERRING, David, and DAWSON, Jesse

Published
2024
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5. Incidence and Outcomes of Patients With Early Cardiac Complications After Intracerebral Hemorrhage: A Report From VISTA

Author

Ishiguchi, Hironori, Huang, Bi, El-Bouri, Wahbi K., Dawson, Jesse, Lip, Gregory Y.H., Abdul-Rahim, Azmil H., Lees, K.R., Alexandrov, A., Bath, P.M., Bluhmki, E., Bornstein, N., Chen, C., Claesson, L., Curram, J., Davis, S.M., Diener, H-C., Donnan, G., Fisher, M., Ginsberg, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M.G., Hommel, M., Kaste, M., Lyden, P., Marler, J., Muir, K., Roffe, C., Sacco, R., Shuaib, A., Teal, P., Venketasubramanian, N., Wahlgren, N.G., and Warach, S.

Published
2024
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6. Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial

Author

Jelley, Benjamin, Hughes, Tom, Evans, Mim, Esteban, Diego Garcia, Knibbs, Lucy, Broad, Lauren, Price, Rebecca, Griebel, Liz Hamer, Hewson, Sian, Thavanesan, Kamy, Mallon, Louise, Smith, Anna, White, Miranda, Zhang, Liqun, Clarke, Brian, Abousleiman, Youssif, Binnie, Lauren, Sim, Cai Hua, Castanheira, Margarida, Humphries, Fiona, Obarey, Sabaa, Feerick, Shez, Lee, Yee Chin, Lewis, Alex, Muhammad, Riham, Francia, Nina, Atang, Ndifreke, Banaras, Azra, Marinescu, Marilena, Ferdinand, Philip, Varquez, Resti, Ponce, Ida, Saxena, Surabhi, O'Brien, Eoin, Reyes, Juliana Delos, Mitchell-Douglas, Jennifer, Francis, Jobbin, Banerjee, Soma, Dave, Vaishali, Mashate, Sheila, Patel, Tulsi, Sekaran, Lakshmanan, Murad, Wahid, Asaipillai, Asokanathan, Sakthivel, Sethuraman, Tate, Margaret, Angus, Jane, Reid, Lisa, Fornolles, Caroline, Sundayi, Saul, Poolon, Lincy, Justin, Francis, Hunte, Sophy, Bhandari, Mohit, Kho, Jules, Cvoro, Vera, Parakramawansha, Ruwan, Couser, Mandy, Hughes, Hannah, Naqvi, Aaizza, Harkness, Kirsty, Richards, Emma, Howe, Jo, Kamara, Chris, Gardner, Jon, Bains, Harjit, Teal, Rachel, Joseph, Jeethu, Benjamin, Jithen, Al-Hussayni, Samer, Thomas, George, Robinson, Faye, Dixon, Lynn, Krishnan, Manju, Slade, Peter, Anjum, Tal, Storton, Sharon, Adie, Katja, Northcott, Keren, Morgan, Katie, Williams, Emilie, Chanashekar, Harinath, Maguire, Holly, Gabriel, Claire, Maren, Deborah, David, Hannah, Clarke, Sheron, Nagaratnam, Kiruba, Nelatur, Varun, Mannava, Neelima, Blasco, Lara, Devine, Joseph, Bathula, Rajaram, Gopi, Parvathy, Mehta, Niharika, Sreedevi Raj, Sreena, Teo, James, Sztriha, Laszio, Mah, Yee, Ankolekar, Sandeep, Sari, Beatrix, Tibajai, Maria, Morgan, Alicia, Recaman, Maria, Bayhonan, Samantha, Belo, Caroline, Finch, Sharon, Keenan, Samantha, Bowring, Angie, Shetty, Ashit, Chan, Siang, Gray, Lucy, Harrison, Thomas, Spooner, Oliver, Kinsella-Perks, Edward, Erumere, Esther, Sanders, Brittany, Sims, Don, Willmot, Mark, Littleton, Edward, Spruce, Elaine, Moody, Lisa, Sheriden, Christopher, Luxmore-Brown, Scott, Neal, Aoife, Beddows, Sophie, Tuna, Maria Assuncao, Misra, Amulya, Penn, Ruth, Mariampillai, Sonia, Anwar, Ijaz, Annamalai, Arunkumar, Whitehouse, Sarah, Shepherd, Lorna, Siddle, Elaine, Chatterjee, Kausik, Leason, Sandra, Davies, Angela, Marigold, Richard James, Frank, Sarah, Baird, Alix, Hannam-Penfold, Tomas, Inacio, Liliana, Smith, Simon, Eveson, David, Musarrat, Kashif, Khan, Shagufta, Harris, Tracy, Chowdhury, Muhibbur, Alam, Sajid, Jamieson, Elena, Anyankpele, Ebitare, Al Shalchi, Farah, Rivers, Vanessa, Bell, Stephanie, Francis, Rebecca, Beeby, Deborah, Finch, Jenny, Macleod, Mary Joan, Guzman-Gutierrez, German, Carter, Karla, Irvine, Janice, Gbadamoshi, Lukuman, Costa, Telma, Heirons, Sarah, Stoney, Hayley, Shaw, Louise, Choulerton, James, Catibog, Darwin, Sattar, Naweed, Myint, Min, Smith, Andy, Serac, Kwin, Emsley, Hedley, Sultan, Sulaiman, Gregary, Bindu, Brown, Allan, Mahmood, Afzal, Chattha, Navraj, Old, William, Pegg, Claire, Davey, Miriam, Page, Michelle, Sandhu, Banher, Phiri, Emily, Rashed, Khalid, Wilson, Elisabeth, Hindley, Esther, Board, Sarah, Antony, Sherly, Tanate, Alfonso, Davis, Michelle, Holland, Beth, Slater, Victoria, Fawcett, Michelle, England, Tim, Scott, James, Beavan, Jessica, Hedstrom, Amanda, Karunatilake, Dumin, Gillmain, Kimberley, Singh, Nishy, Hallows, Tracy, Barber, Mark, Yates, Luke, Micallef, Clayton, Esson, Derek, Meng Yu, Wai, Ming New, Benjamin Jaa, Matos, Alexandre, Burt, Clare, Cabrelli, Louise, Wilkie, Gillian, Meegada, Madana, Kirthivasan, Ramanathan, Fox, Caroline, Mead, Victoria, Lyle, Amanda, Saksena, Rajesh, Bakshi, Aashima, O'Kelly, Alison, Rehan, Jahanzeb, Ebueka, Osaretin, Cooper, Martin, Wynter, Inez, Smith, Susan, Kumar, Senthil, O'Brien, Linda, Parker, Cerrys, Parker, Emma, Khan, Numan, Patterson, Christopher, Maguire, Stuart, Quinn, Outi, Bellfield, Ruth, Behnam, Yousif, Costa, Janet, Padilla-Harris, Cheryl, Moram, Louise, Raza, Syed Abid, Tench, Helen, Sims, Tanya, McGuinness, Heather, Loosley, Ronda, Wolf-Roberts, Rebecca, Buddha, Sandeep, Salt, Irmak, Lewis, Kerry, Mavinamne, Sunanda, Ditchfield, Coleen, Dealing, Sharon, Shah, Alexander, Crossingham, Ginette, Mwadeyi, Memory, Kenton, Anthony, Omoregie, Faith, Abubakar, Saidu, Warwick, Allison, Hector, Gemma, Hassan, Ahamad, Veraque, Emelda, Farman, Michelle, Makawa, Linetty, Byrne, Anthony, Kirkham, Jackie, Blayney, Gareth, Selwyn, Jey, Kakar, Puneet, Al Khaddour, Mohammed, Dhami, Reena, Baker, Emelda, Esisi, Bernard, Clarkson, Emma, Fellowes, Dominic, Kresmir, Jergovic, Guyler, Paul, Ngo, David, Wijenayake, Indunil, Tysoe, Sharon, Galliford, Joanne, Harman, Paula, Garside, Mark, Badanahatti, Madhava, Riddell, Victoria, Gramizadeh, Gita, Dutta, Dipankar, Bajoriene, Milda, Erdogan, Hulya, Ward, Deborah, Doubal, Fergus, Samarasekera, Neshika, Risbridger, Sarah, MacRaild, Allan, Azim, Abul, Wood, Lisa, Tampset, Ruth, Shekhar, Raj, Rai, Umesh, Fuller, Tracy, Joshy, Aricsa, Nadar, Evelyn, Kini, Manohar, Ahmad, Syed, Robinson, Matthew, King, Lucia, Srinivasan, Venkatesan, Karwacka-Cichomska, Magdalena, Moore, Vicki, Smith, Kate, Kariyadil, Bincy, Kong, Kelvin, Hubbard, Kelly, Arif, Sarwat, Hasan, Muhammad, Temple, Natalie, Arcoria, Daniele, Horne, Zoey, Soe, Thandar, Wyllie, Hilary, Hacon, Christian, Sutherland, Helen, Menezes, Brian, Johnson, Venetia, Smyth, Nigel, Mehdi, Zehra, Tone, Ela, Bradley, Arian, Levell, Emma, Ekkert, Aleksandra, Mazzucco, Sara, McCafferty, Laura, Vonoven, Linda, Dewan, Suprita, Sridhar, Pagadala, Thomas, Jayne, Coetzee, Samantha, Icke, Becky, Williams, Jill, Saravanan, Narayanamoorthi, Bradley, Pamela, Gibson, Rebecca Marie, Antony, Jijimol, Ashraf, Imran, Mabuti, Jose, Kamundi, Charlotte, Patiola, Prasanna, Oakley, Naomi, Proeschel, Harold, Kelly, Debs, Longley, Wendy, Cave, Ashleigh, Ambrico, Carla, Black, Toby, Porretta, Elisa, Anthony, Alpha, Ragab, Suzanne, Dube, Judith, Kausar, Shahid, Gujjar, Abdullah, Abdullah, Mohammad, Kaur, Daljit, Gadapa, Naveen, Choudhary, Sumita, Nisar, Nabeela, Fawehinmi, Grace, Dunne, Karen, King, Sam, Kishore, Amit, Lee, Stephanie, Marsden, Tracy, Slaughter, Melanie, Cawley, Kathryn, Perez, Jane, Anderton, Peter, Soussi, Salem, Walstow, Deborah, Pugh, Rebecca, Manoj, Aravind, Fletcher, Glynn, Lopez, Paula, McCormick, Michael, Magee, Michael, Tallon, Grainne, McFarland, Denise, Cosgrove, Denise, Shinh, Naval, Metcalf, Kneale, Kostyuk, Alina, McDonald, Susan, Sayers, Sophie, Sayed, Walee, Abraham, Sam, Szabo, Gemma, Crosbie, Gareth, McIlmoyle, Jim, Fearon, Patricia, Courtney, Kerry, Tauro, Suzanne, Singh, Arun, Nair, Anand, Duberley, Stephen, Philip, Sheeba, Curley, Cath, Goddard, Wendy, Bridge, Luke, Willcoxson, Paul, Wanklyn, Peter, Owen, Jennifer, France, John, Reed, Bryony, Foulds, Angie, Richard, Bella, Parfitt, Louise, Affley, Brendan, Russo, Cristina, Dsouza, Margaret, Cruddas, Elizabeth, Hargroves, David, Rand, James, Shekar, Som, Bhat, Yaqoob, Marshall, Gail, Nash, Maxine, Ahmad, Nasar, Okoko, Blessing Oduh, Evans, Rachel, Taylor, Tegan, Dawson, Jesse, Colquhoun, Elizabeth, James, Christopher, Aguirre, Carlos, MacPhee, Catherine, Phipps, Janet, Ispoglou, Sissi, Hayes, Anne, Werring, David J, Dehbi, Hakim-Moulay, Ahmed, Norin, Arram, Liz, Best, Jonathan G, Balogun, Maryam, Bennett, Kate, Bordea, Ekaterina, Caverly, Emilia, Chau, Marisa, Cohen, Hannah, Cullen, Mairead, Doré, Caroline J, Engelter, Stefan T, Fenner, Robert, Ford, Gary A, Gill, Aneet, Hunter, Rachael, James, Martin, Jayanthi, Archana, Lip, Gregory Y H, Massingham, Sue, Murray, Macey L, Mazurczak, Iwona, Nash, Philip S, Ndoutoumou, Amalia, Norrving, Bo, Sims, Hannah, Sprigg, Nikola, Vanniyasingam, Tishok, and Freemantle, Nick

Published
2024
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7. Early Versus Late Initiation of Direct Oral Anticoagulants After Ischemic Stroke in People With Atrial Fibrillation and Hemorrhagic Transformation: Prespecified Subanalysis of the Randomized Controlled ELAN Trial

Author

Rohner, Roman, Kneihsl, Markus, Goeldlin, Martina B., Hakim, Arsany, Branca, Mattia, Abend, Stefanie, Valenzuela Pinilla, Waldo, Fenzl, Sabine, Rezny-Kasprzak, Beata, Strbian, Daniel, Trelle, Sven, Paciaroni, Maurizio, Thomalla, Götz, Michel, Patrik, Nedeltchev, Krassen, Gattringer, Thomas, Sandset, Else C., Bonati, Leo, Aguiar de Sousa, Diana, Sylaja, P.N., Ntaios, George, Koga, Masatoshi, Gdovinova, Zuzana, Lemmens, Robin, Bornstein, Natan M., Kelly, Peter, Katan, Mira, Horvath, Thomas, Dawson, Jesse, and Fischer, Urs

Published
2024
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11. Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment

Author

Kerkhoff, Henk, Wermer, Marieke JH., Jellema, Korné, Kwa, Vincent IH., Jansen, Ben P., Schreuder, Tobien AHCML., Zinkstok, Sanne M., Moudrous, Walid, Antsov, Katrin, Gross-Paju, Katrin, Kalju, Inga, Hamann, Gerhard F., Rosenkranz, Michael, Gumbinger, Christoph, Royl, Georg, Müller, Susanne, Vassilopoulou, Sophie, Protogerou, Athanasios D., Manios, Efstathios, Bereczki, Dániel, Jakab, Gábor, Nagy, Ferenc, Folyovich, András, Szapáry, László, Gilberti, Nicola, Righetti, Enrico, Bassi, Pietro, Marcheselli, Simona, Giossi, Alessia, Holtan, Anne G., Maini, Sameer, Fryze, Waldemar, Brola, Waldemar, Sobolewski, Piotr, Bilik, Marta, Davies, Ruth, Nair, Anand, Dutta, Dipankar, Cooper, Martin, Rashed, Khalid, Shaw, Louise, Selvarajah, Johann R., Redgrave, Jessica, MacLeod, Mary Joan, Clatworthy, Philip, Papavasileiou, Vasileios, Cvoro, Vera, Halse, Omid, Ghani, Usman, de Jonge, Jeroen C., Sluis, Wouter M., Reinink, Hendrik, Bath, Philip M., Woodhouse, Lisa J., Zweedijk, Berber, van de Beek, Diederik, Aamodt, Anne Hege, Alpers, Iris, Ciccone, Alfonso, Csiba, Laszlo, Demotes, Jacques, Kõrv, Janika, Kurkowska-Jastrzebska, Iwona, Dawson, Jesse, Macleod, Malcolm R., Ntaios, George, Poli, Sven, Milionis, Haralampos, Ricci, Stefano, Cenciarelli, Silvia, Candelaresi, Paolo, de Bruijn, Sebastiaan FTM., Pathansali, Rohan, Krishnan, Kailash, Clarke, Brian, Thomalla, Götz, and van der Worp, H Bart

Published
2024
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12. Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial

Author

Sharma, Mukul, Molina, Carlos A, Toyoda, Kazunori, Bereczki, Daniel, Bangdiwala, Shrikant I, Kasner, Scott E, Lutsep, Helmi L, Tsivgoulis, Georgios, Ntaios, George, Czlonkowska, Anna, Shuaib, Ashfaq, Amarenco, Pierre, Endres, Matthias, Yoon, Byung-Woo, Tanne, David, Toni, Danilo, Yperzeele, Laetitia, von Weitzel-Mudersbach, Paul, Sampaio Silva, Gisele, Avezum, Alvaro, Dawson, Jesse, Strbian, Daniel, Tatlisumak, Turgut, Eckstein, Jens, Ameriso, Sebastián F, Weber, Joerg R, Sandset, Else Charlotte, Goar Pogosova, Nana, Lavados, Pablo M, Arauz, Antonio, Gailani, David, Diener, Hans-Christoph, Bernstein, Richard A, Cordonnier, Charlotte, Kahl, Anja, Abelian, Grigor, Donovan, Mark, Pachai, Chahin, Li, Danshi, and Hankey, Graeme J

Published
2024
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13. Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial

Author

Dawson, Jesse, Liu, Charles Y, Francisco, Gerard E, Cramer, Steven C, Wolf, Steven L, Dixit, Anand, Alexander, Jen, Ali, Rushna, Brown, Benjamin L, Feng, Wuwei, DeMark, Louis, Hochberg, Leigh R, Kautz, Steven A, Majid, Arshad, O'Dell, Michael W, Pierce, David, Prudente, Cecília N, Redgrave, Jessica, Turner, Duncan L, Engineer, Navzer D, and Kimberley, Teresa J

Subjects
Allied Health and Rehabilitation Science, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Rehabilitation, Physical Rehabilitation, Brain Disorders, Stroke, Neurosciences, Clinical Research, Clinical Trials and Supportive Activities, 6.3 Medical devices, Evaluation of treatments and therapeutic interventions, 6.7 Physical, Aged, Case-Control Studies, Combined Modality Therapy, Exercise Therapy, Female, Humans, Implantable Neurostimulators, Ischemic Stroke, Male, Middle Aged, Outcome Assessment, Health Care, Paresis, Recovery of Function, Stroke Rehabilitation, Treatment Outcome, Upper Extremity, Vagus Nerve Stimulation, Vocal Cord Paralysis, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundLong-term loss of arm function after ischaemic stroke is common and might be improved by vagus nerve stimulation paired with rehabilitation. We aimed to determine whether this strategy is a safe and effective treatment for improving arm function after stroke.MethodsIn this pivotal, randomised, triple-blind, sham-controlled trial, done in 19 stroke rehabilitation services in the UK and the USA, participants with moderate-to-severe arm weakness, at least 9 months after ischaemic stroke, were randomly assigned (1:1) to either rehabilitation paired with active vagus nerve stimulation (VNS group) or rehabilitation paired with sham stimulation (control group). Randomisation was done by ResearchPoint Global (Austin, TX, USA) using SAS PROC PLAN (SAS Institute Software, Cary, NC, USA), with stratification by region (USA vs UK), age (≤30 years vs >30 years), and baseline Fugl-Meyer Assessment-Upper Extremity (FMA-UE) score (20-35 vs 36-50). Participants, outcomes assessors, and treating therapists were masked to group assignment. All participants were implanted with a vagus nerve stimulation device. The VNS group received 0·8 mA, 100 μs, 30 Hz stimulation pulses, lasting 0·5 s. The control group received 0 mA pulses. Participants received 6 weeks of in-clinic therapy (three times per week; total of 18 sessions) followed by a home exercise programme. The primary outcome was the change in impairment measured by the FMA-UE score on the first day after completion of in-clinic therapy. FMA-UE response rates were also assessed at 90 days after in-clinic therapy (secondary endpoint). All analyses were by intention to treat. This trial is registered at ClinicalTrials.gov, NCT03131960.FindingsBetween Oct 2, 2017, and Sept 12, 2019, 108 participants were randomly assigned to treatment (53 to the VNS group and 55 to the control group). 106 completed the study (one patient for each group did not complete the study). On the first day after completion of in-clinic therapy, the mean FMA-UE score increased by 5·0 points (SD 4·4) in the VNS group and by 2·4 points (3·8) in the control group (between group difference 2·6, 95% CI 1·0-4·2, p=0·0014). 90 days after in-clinic therapy, a clinically meaningful response on the FMA-UE score was achieved in 23 (47%) of 53 patients in the VNS group versus 13 (24%) of 55 patients in the control group (between group difference 24%, 6-41; p=0·0098). There was one serious adverse event related to surgery (vocal cord paresis) in the control group.InterpretationVagus nerve stimulation paired with rehabilitation is a novel potential treatment option for people with long-term moderate-to-severe arm impairment after ischaemic stroke.FundingMicroTransponder.

Published
2021

16. Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial

Author

Dawson, Jesse, Robertson, Michele, Dickie, David Alexander, Bath, Phillip, Forbes, Kirsten, Quinn, Terence, Broomfield, Niall M., Dani, Krishna, Doney, Alex, Houston, Graeme, Lees, Kennedy R., Muir, Keith W., Struthers, Allan, Walters, Matthew, Barber, Mark, Bhalla, Ajay, Cameron, Alan, Dyker, Alexander, Guyler, Paul, Hassan, Ahamad, Kearney, Mark T., Keegan, Breffni, Lakshmanan, Sekaran, Macleod, Mary Joan, Randall, Marc, Shaw, Louise, Subramanian, Ganesh, Werring, David, and McConnachie, Alex

Published
2023
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20. Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial

Author

Ahmed, Husnat, Arthur, Peter, Aziz, Jane, Barnes, Lawrence, Boyle, Sarah, Brighton, Tom, Brown, Morris, Caulfield, Mark, Dawson, Jesse, Denvir, Martin, Doney, Alexander SF, Doshi, Sagar, Dryburgh, Moira, Eddleston, Michael, Finlayson, Jim, Fuat, Ahmet, Furnace, Jacqueline, Grieve, JW Kerr, Guthrie, Greg, Ham, Sharon, Isaard, Emma, Jennings, Claudine, Johnson, Richard, Kerr, Claire, Khan, Sohail, Krishnan, Kailash, Long, Susan, Mackintosh, Anne, Macleod, Mary Joan, McCormack, Terry, McEleny, Paul, Morar, Monique, Nadir, Adnan, Newby, David, Petrie, Colin, Preiss, David, Ralston, Stuart, Randall, Marc, Routledge, Helen, Shakir, Saad, Sharma, Raj, Shepherd, Bridget, Sims, Don, Snedden, Gordon, Trevelyan, Jasper, Weir, Christopher, Weir, Robin, Wetherall, Kirsty, Wilson, Robbie, Wilson, Adam, Zutis, Kris, Mackenzie, Isla S, Hawkey, Christopher J, Ford, Ian, Greenlaw, Nicola, Pigazzani, Filippo, Rogers, Amy, Struthers, Allan D, Begg, Alan G, Wei, Li, Avery, Anthony J, Taggar, Jaspal S, Walker, Andrew, Duce, Suzanne L, Barr, Rebecca J, Dumbleton, Jennifer S, Rooke, Evelien D, Townend, Jonathan N, Ritchie, Lewis D, and MacDonald, Thomas M

Published
2022
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21. Risk of major adverse cardiovascular events and all-cause mortality under treatment with GLP-1 RAs or the dual GIP/GLP-1 receptor agonist tirzepatide in overweight or obese adults without diabetes: a systematic review and meta-analysis.

Author

Stefanou, Maria-Ioanna, Palaiodimou, Lina, Theodorou, Aikaterini, Safouris, Apostolos, Fischer, Urs, Kelly, Peter J., Dawson, Jesse, Katan, Mira, Katsanos, Aristeidis H., Lambadiari, Vaia, Giannopoulos, Sotirios, Alexandrov, Andrei V., Siasos, Gerasimos, and Tsivgoulis, Georgios

Subjects
MAJOR adverse cardiovascular events, ANTIOBESITY agents, MYOCARDIAL infarction, MORTALITY, GLUCAGON-like peptide-1 agonists
Abstract

Background: Among the currently approved antiobesity medications, the glucagon-like-peptide-1 receptor-agonists (GLP-1 RAs) liraglutide and semaglutide, and the dual glucose-dependent-insulinotropic-polypeptide (GIP)/GLP-1 RA tirzepatide have been suggested to reduce cardiovascular-risk in overweight or obesity without diabetes. Objectives: The objective of this study was to evaluate the cardio- and neuroprotective potential of these novel agents in the nondiabetic overweight/obese adult population. Data sources and methods: A systematic review and meta-analysis of randomized-controlled clinical trials (RCTs) was performed to estimate the risk of major adverse cardiovascular events (MACE), all-cause and cardiovascular mortality in overweight or obese adults without diabetes treated with GLP-1 or GIP/GLP-1 RAs (vs placebo). Secondary outcomes included the risk of myocardial infarction (MI) and stroke. Results: Sixteen RCTs (13 and 3 on GLP-1 RAs and tirzepatide, respectively) comprising 28,168 participants were included. GLP-1 or GIP/GLP-1 RAs reduced MACE (odds ratio (OR): 0.79; 95% confidence interval (CI): 0.71–0.89; p < 0.01; I 2 = 0) and all-cause mortality (OR: 0.80; 95% CI: 0.70–0.92; p < 0.01; I 2 = 0), while there was a trend toward lower cardiovascular-mortality (OR: 0.84; 95% CI: 0.71–1.01; p = 0.06; I 2 = 0%) compared to placebo. Additionally, GLP-1 or GIP/GLP-1 RAs reduced the odds of MI (OR: 0.72; 95% CI: 0.61–0.86; p < 0.01; I 2 = 0%) and nonfatal-MI (OR: 0.72; 95% CI: 0.61–0.85; p < 0.01; I 2 = 0%); while no associations between antiobesity treatment and fatal-MI, stroke, nonfatal, or fatal stroke were uncovered. Conclusion: GLP-1 and GIP/GLP-1 RAs reduce cardiovascular-risk and all-cause mortality in overweight or obese adults without diabetes. Additionally, GLP-1 RAs and GIP/GLP-1 RAs attenuate the risk of MI. Since data on stroke are still limited, future RCTs are warranted to evaluate the neuroprotective potential of these novel antiobesity agents. Trial registration: PROSPERO CRD42024515966. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Vagus Nerve Stimulation Paired With Upper Limb Rehabilitation After Chronic Stroke.

Author

Kimberley, Teresa J, Pierce, David, Prudente, Cecília N, Francisco, Gerard E, Yozbatiran, Nuray, Smith, Patricia, Tarver, Brent, Engineer, Navzer D, Alexander Dickie, David, Kline, Danielle K, Wigginton, Jane G, Cramer, Steven C, and Dawson, Jesse

Subjects
Upper Extremity, Humans, Chronic Disease, Combined Modality Therapy, Exercise Therapy, Feasibility Studies, Pilot Projects, Double-Blind Method, Recovery of Function, Adult, Aged, Middle Aged, Female, Male, Stroke, Vagus Nerve Stimulation, Stroke Rehabilitation, motor cortex, neuromodulation, plasticity, rehabilitation, stroke, upper extremity, vagus nerve, Clinical Sciences, Cardiorespiratory Medicine and Haematology, Neurosciences, Neurology & Neurosurgery
Abstract

Background and Purpose- We assessed safety, feasibility, and potential effects of vagus nerve stimulation (VNS) paired with rehabilitation for improving arm function after chronic stroke. Methods- We performed a randomized, multisite, double-blinded, sham-controlled pilot study. All participants were implanted with a VNS device and received 6-week in-clinic rehabilitation followed by a home exercise program. Randomization was to active VNS (n=8) or control VNS (n=9) paired with rehabilitation. Outcomes were assessed at days 1, 30, and 90 post-completion of in-clinic therapy. Results- All participants completed the course of therapy. There were 3 serious adverse events related to surgery. Average FMA-UE scores increased 7.6 with active VNS and 5.3 points with control at day 1 post-in-clinic therapy (difference, 2.3 points; CI, -1.8 to 6.4; P=0.20). At day 90, mean scores increased 9.5 points from baseline with active VNS, and the control scores improved by 3.8 (difference, 5.7 points; CI, -1.4 to 11.5; P=0.055). The clinically meaningful response rate of FMA-UE at day 90 was 88% with active VNS and 33% with control VNS ( P

Published
2018

24. Timing of oral anticoagulants initiation for atrial fibrillation after acute ischemic stroke: A systematic review and meta-analysis

Author

Palaiodimou, Lina, primary, Stefanou, Maria-Ioanna, additional, Katsanos, Aristeidis H, additional, De Marchis, Gian Marco, additional, Aguiar De Sousa, Diana, additional, Dawson, Jesse, additional, Katan, Mira, additional, Karapanayiotides, Theodore, additional, Toutouzas, Konstantinos, additional, Paciaroni, Maurizio, additional, Seiffge, David J, additional, and Tsivgoulis, Georgios, additional

Published
2024
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25. Statin Therapy in Ischemic Stroke Patients with Atrial Fibrillation: Efficacy and Safety Outcomes

Author

Marvardi, Michele, primary, Ferrante, Mario, additional, Paciaroni, Maurizio, additional, Abdul-Rahim, Azmil H, additional, Tsivgoulis, Georgios, additional, Seiffge, David J, additional, Engelter, Stefan T, additional, Lyrer, Philippe A., additional, Polymeris, Alexandros A, additional, Dittrich, Tolga D, additional, Cancelloni, Virginia, additional, Zietz, Annaelle, additional, De Marchis, Gian Marco, additional, Putaala, Jukka, additional, Strbian, Daniel, additional, Tomppo, Liisa, additional, Michel, Patrik, additional, Strambo, Davide, additional, Salerno, Alexander, additional, Vanacker, Peter, additional, Zuurbier, Susanna M., additional, Yperzeele, Laetitia, additional, Loos, Caroline MJ, additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Zedde, Marialuisa, additional, Becattini, Cecilia, additional, Pascarella, Rosario, additional, Dawson, Jesse, additional, Cronshaw, Robert, additional, Schirinzi, Erika, additional, Del Sette, Massimo, additional, Stretz, Christoph, additional, Kala, Narendra Sharma, additional, Schomer, Ashley, additional, Mac Grory, Brian, additional, Jayaraman, Mahesh V, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Toni, Danilo, additional, Risitano, Angela, additional, Falcou, Anne A, additional, Petraglia, Luca, additional, Lotti, Enrico Maria, additional, Pavolucci, Lucia, additional, Lochner, Piergiorgio, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Alberti, Andrea, additional, Venti, Michele, additional, Leone De Magistris, Ilaria, additional, Mosconi, Maria Giulia, additional, Giustozzi, Michela, additional, Kargiotis, Odysseas, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Marcheselli, Simona, additional, Antonenko, Kateryna, additional, Rota, Eugenia, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, Palmerini, Francesco, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Monaco, Serena, additional, Cottone, Salvatore, additional, Baldi, Antonio, additional, D'Amore, Cataldo, additional, Ageno, Walter, additional, Pegoraro, Samuela, additional, Ntaios, George, additional, Adamou, Anastasia, additional, Sagris, Dimitrios, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Romoli, Michele, additional, Pantoni, Leonardo, additional, Rosa, Silvia, additional, Bertora, Pierluigi, additional, Chiti, Alberto, additional, Canavero, Isabella, additional, Saggese, Carlo Emanuele, additional, Plocco, Maurizio, additional, Giorli, Elisa, additional, Palaiodimou, Lina, additional, Bakola, Eleni, additional, Bandini, Fabio, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Pezzini, Alessandro, additional, Ornello, Raffaele, additional, Sacco, Simona, additional, Popovic, Nemanja, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, D'agliano, Roberto, additional, Baldini, Marco, additional, Ulivi, Leonardo, additional, Giannini, Nicola, additional, Vadikolias, Konstantinos, additional, Liantinioti, Chrysoula, additional, Chondrogianni, Maria, additional, Halvatsiotis, Panagiotis, additional, Karagkiozi, Efstathia, additional, Athanasakis, George, additional, Makaritsis, Konstantinos, additional, lanari, alessia, additional, Tatlisumak, Turgut, additional, Acciarresi, Monica, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Sohn, Sung-Il, additional, Mumoli, Nicola, additional, Cararra, Davide, additional, Maccarrone, Miriam, additional, Galati, Franco, additional, Gourbali, Vanessa, additional, Orlandi, Giovanni, additional, Giuntini, Martina, additional, Corea, Francesco, additional, Bellesini, Marta, additional, Karapanayiotides, Theodore, additional, Csiba, Laszlo, additional, Szabo, Lilla, additional, Imberti, Davide, additional, Pieroni, Alessio, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Barlinn, Jessica, additional, Doronin, Boris, additional, Volodina, Vera Alexandrovna, additional, Agnelli, Giancarlo, additional, Deleu, Dirk, additional, Bonetti, Bruno, additional, Gentile, Luana, additional, Reale, Giuseppe, additional, Caliandro, Pietro, additional, Morotti, Andrea, additional, Vannucchi, Vieri, additional, Padroni, Marina, additional, Letteri, Federica, additional, Magoni, Mauro, additional, Tiseo, Cindy, additional, Rigatelli, Alberto, additional, Zauli, Aurelia, additional, Bossi, Francesco, additional, and Caso, Valeria, additional

Published
2024
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27. Antiseizure Medications in Post-stroke Seizures: A Systematic Review and Network Meta-analysis (P8-1.012)

Author

Misra, Shubham, primary, Dawson, Jesse, additional, Kwan, Patrick, additional, Kasner, Scott E., additional, Grotta, James C., additional, Larsson, David, additional, Tanaka, Tomotaka, additional, Zaveri, Hitten, additional, Wang, Selena, additional, Khan, Erum I., additional, Funaro, Melissa, additional, Perla, Sravan, additional, Dev, Priya, additional, Hussain, Taimoor, additional, Liebeskind, David S., additional, Yasuda, Clarissa, additional, Elshahat, Amr, additional, Hitawala, Gazala, additional, Wang, Ethan, additional, Kitagawa, Rachel, additional, Pathak, Abhishek, additional, Zhao, Yize, additional, Scalzo, Fabien, additional, Ihara, Masafumi, additional, Zelano, Johan, additional, Sunnerhagen, Katharina, additional, Walters, Matthew, additional, Jette, Nathalie, additional, Quinn, Terry, additional, and Mishra, Nishant, additional

Published
2024
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28. Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial

Author

Werring, David J, Dehbi, Hakim-Moulay, Ahmed, Norin, Arram, Liz, Best, Jonathan G, Balogun, Maryam, Bennett, Kate, Bordea, Ekaterina, Caverly, Emilia, Chau, Marisa, Cohen, Hannah, Cullen, Mairead, Doré, Caroline J, Engelter, Stefan T, Fenner, Robert, Ford, Gary A, Gill, Aneet, Hunter, Rachael, James, Martin, Jayanthi, Archana, Lip, Gregory Y H, Massingham, Sue, Murray, Macey L, Mazurczak, Iwona, Nash, Philip S, Ndoutoumou, Amalia, Norrving, Bo, Sims, Hannah, Sprigg, Nikola, Vanniyasingam, Tishok, Freemantle, Nick, Jelley, Benjamin, Hughes, Tom, Evans, Mim, Esteban, Diego Garcia, Knibbs, Lucy, Broad, Lauren, Price, Rebecca, Griebel, Liz Hamer, Hewson, Sian, Thavanesan, Kamy, Mallon, Louise, Smith, Anna, White, Miranda, Zhang, Liqun, Clarke, Brian, Abousleiman, Youssif, Binnie, Lauren, Sim, Cai Hua, Castanheira, Margarida, Humphries, Fiona, Obarey, Sabaa, Feerick, Shez, Lee, Yee Chin, Lewis, Alex, Muhammad, Riham, Francia, Nina, Atang, Ndifreke, Banaras, Azra, Marinescu, Marilena, Ferdinand, Philip, Varquez, Resti, Ponce, Ida, Saxena, Surabhi, O'Brien, Eoin, Reyes, Juliana Delos, Mitchell-Douglas, Jennifer, Francis, Jobbin, Banerjee, Soma, Dave, Vaishali, Mashate, Sheila, Patel, Tulsi, Sekaran, Lakshmanan, Murad, Wahid, Asaipillai, Asokanathan, Sakthivel, Sethuraman, Tate, Margaret, Angus, Jane, Reid, Lisa, Fornolles, Caroline, Sundayi, Saul, Poolon, Lincy, Justin, Francis, Hunte, Sophy, Bhandari, Mohit, Kho, Jules, Cvoro, Vera, Parakramawansha, Ruwan, Couser, Mandy, Hughes, Hannah, Naqvi, Aaizza, Harkness, Kirsty, Richards, Emma, Howe, Jo, Kamara, Chris, Gardner, Jon, Bains, Harjit, Teal, Rachel, Joseph, Jeethu, Benjamin, Jithen, Al-Hussayni, Samer, Thomas, George, Robinson, Faye, Dixon, Lynn, Krishnan, Manju, Slade, Peter, Anjum, Tal, Storton, Sharon, Adie, Katja, Northcott, Keren, Morgan, Katie, Williams, Emilie, Chanashekar, Harinath, Maguire, Holly, Gabriel, Claire, Maren, Deborah, David, Hannah, Clarke, Sheron, Nagaratnam, Kiruba, Nelatur, Varun, Mannava, Neelima, Blasco, Lara, Devine, Joseph, Bathula, Rajaram, Gopi, Parvathy, Mehta, Niharika, Sreedevi Raj, Sreena, Teo, James, Sztriha, Laszio, Mah, Yee, Ankolekar, Sandeep, Sari, Beatrix, Tibajai, Maria, Morgan, Alicia, Recaman, Maria, Bayhonan, Samantha, Belo, Caroline, Finch, Sharon, Keenan, Samantha, Bowring, Angie, Shetty, Ashit, Chan, Siang, Gray, Lucy, Harrison, Thomas, Spooner, Oliver, Kinsella-Perks, Edward, Erumere, Esther, Sanders, Brittany, Sims, Don, Willmot, Mark, Littleton, Edward, Spruce, Elaine, Moody, Lisa, Sheriden, Christopher, Luxmore-Brown, Scott, Neal, Aoife, Beddows, Sophie, Tuna, Maria Assuncao, Misra, Amulya, Penn, Ruth, Mariampillai, Sonia, Anwar, Ijaz, Annamalai, Arunkumar, Whitehouse, Sarah, Shepherd, Lorna, Siddle, Elaine, Chatterjee, Kausik, Leason, Sandra, Davies, Angela, Marigold, Richard James, Frank, Sarah, Baird, Alix, Hannam-Penfold, Tomas, Inacio, Liliana, Smith, Simon, Eveson, David, Musarrat, Kashif, Khan, Shagufta, Harris, Tracy, Chowdhury, Muhibbur, Alam, Sajid, Jamieson, Elena, Anyankpele, Ebitare, Al Shalchi, Farah, Rivers, Vanessa, Bell, Stephanie, Francis, Rebecca, Beeby, Deborah, Finch, Jenny, Macleod, Mary Joan, Guzman-Gutierrez, German, Carter, Karla, Irvine, Janice, Gbadamoshi, Lukuman, Costa, Telma, Heirons, Sarah, Stoney, Hayley, Shaw, Louise, Choulerton, James, Catibog, Darwin, Sattar, Naweed, Myint, Min, Smith, Andy, Serac, Kwin, Emsley, Hedley, Sultan, Sulaiman, Gregary, Bindu, Brown, Allan, Mahmood, Afzal, Chattha, Navraj, Old, William, Pegg, Claire, Davey, Miriam, Page, Michelle, Sandhu, Banher, Phiri, Emily, Rashed, Khalid, Wilson, Elisabeth, Hindley, Esther, Board, Sarah, Antony, Sherly, Tanate, Alfonso, Davis, Michelle, Holland, Beth, Slater, Victoria, Fawcett, Michelle, England, Tim, Scott, James, Beavan, Jessica, Hedstrom, Amanda, Karunatilake, Dumin, Gillmain, Kimberley, Singh, Nishy, Hallows, Tracy, Barber, Mark, Yates, Luke, Micallef, Clayton, Esson, Derek, Meng Yu, Wai, Ming New, Benjamin Jaa, Matos, Alexandre, Burt, Clare, Cabrelli, Louise, Wilkie, Gillian, Meegada, Madana, Kirthivasan, Ramanathan, Fox, Caroline, Mead, Victoria, Lyle, Amanda, Saksena, Rajesh, Bakshi, Aashima, O'Kelly, Alison, Rehan, Jahanzeb, Ebueka, Osaretin, Cooper, Martin, Wynter, Inez, Smith, Susan, Kumar, Senthil, O'Brien, Linda, Parker, Cerrys, Parker, Emma, Khan, Numan, Patterson, Christopher, Maguire, Stuart, Quinn, Outi, Bellfield, Ruth, Behnam, Yousif, Costa, Janet, Padilla-Harris, Cheryl, Moram, Louise, Raza, Syed Abid, Tench, Helen, Sims, Tanya, McGuinness, Heather, Loosley, Ronda, Wolf-Roberts, Rebecca, Buddha, Sandeep, Salt, Irmak, Lewis, Kerry, Mavinamne, Sunanda, Ditchfield, Coleen, Dealing, Sharon, Shah, Alexander, Crossingham, Ginette, Mwadeyi, Memory, Kenton, Anthony, Omoregie, Faith, Abubakar, Saidu, Warwick, Allison, Hector, Gemma, Hassan, Ahamad, Veraque, Emelda, Farman, Michelle, Makawa, Linetty, Byrne, Anthony, Kirkham, Jackie, Blayney, Gareth, Selwyn, Jey, Kakar, Puneet, Al Khaddour, Mohammed, Dhami, Reena, Baker, Emelda, Esisi, Bernard, Clarkson, Emma, Fellowes, Dominic, Kresmir, Jergovic, Guyler, Paul, Ngo, David, Wijenayake, Indunil, Tysoe, Sharon, Galliford, Joanne, Harman, Paula, Garside, Mark, Badanahatti, Madhava, Smith, Anna, Riddell, Victoria, Gramizadeh, Gita, Dutta, Dipankar, Bajoriene, Milda, Erdogan, Hulya, Ward, Deborah, Doubal, Fergus, Samarasekera, Neshika, Risbridger, Sarah, MacRaild, Allan, Azim, Abul, Wood, Lisa, Tampset, Ruth, Shekhar, Raj, Rai, Umesh, Fuller, Tracy, Joshy, Aricsa, Nadar, Evelyn, Kini, Manohar, Ahmad, Syed, Robinson, Matthew, King, Lucia, Srinivasan, Venkatesan, Karwacka-Cichomska, Magdalena, Moore, Vicki, Smith, Kate, Kariyadil, Bincy, Kong, Kelvin, Hubbard, Kelly, Arif, Sarwat, Hasan, Muhammad, Temple, Natalie, Arcoria, Daniele, Horne, Zoey, Soe, Thandar, Wyllie, Hilary, Hacon, Christian, Sutherland, Helen, Menezes, Brian, Johnson, Venetia, Smyth, Nigel, Mehdi, Zehra, Tone, Ela, Bradley, Arian, Levell, Emma, Ekkert, Aleksandra, Mazzucco, Sara, McCafferty, Laura, Vonoven, Linda, Dewan, Suprita, Sridhar, Pagadala, Thomas, Jayne, Coetzee, Samantha, Icke, Becky, Williams, Jill, Saravanan, Narayanamoorthi, Bradley, Pamela, Gibson, Rebecca Marie, Antony, Jijimol, Ashraf, Imran, Mabuti, Jose, Kamundi, Charlotte, Patiola, Prasanna, Oakley, Naomi, Proeschel, Harold, Kelly, Debs, Longley, Wendy, Cave, Ashleigh, Ambrico, Carla, Black, Toby, Porretta, Elisa, Anthony, Alpha, Ragab, Suzanne, Dube, Judith, Kausar, Shahid, Gujjar, Abdullah, Abdullah, Mohammad, Kaur, Daljit, Gadapa, Naveen, Choudhary, Sumita, Nisar, Nabeela, Fawehinmi, Grace, Dunne, Karen, King, Sam, Kishore, Amit, Lee, Stephanie, Marsden, Tracy, Slaughter, Melanie, Cawley, Kathryn, Perez, Jane, Anderton, Peter, Soussi, Salem, Walstow, Deborah, Pugh, Rebecca, Manoj, Aravind, Fletcher, Glynn, Lopez, Paula, McCormick, Michael, Magee, Michael, Tallon, Grainne, McFarland, Denise, Cosgrove, Denise, Shinh, Naval, Metcalf, Kneale, Kostyuk, Alina, McDonald, Susan, Sayers, Sophie, Sayed, Walee, Abraham, Sam, Szabo, Gemma, Crosbie, Gareth, McIlmoyle, Jim, Fearon, Patricia, Courtney, Kerry, Tauro, Suzanne, Singh, Arun, Nair, Anand, Duberley, Stephen, Philip, Sheeba, Curley, Cath, Goddard, Wendy, Bridge, Luke, Willcoxson, Paul, Wanklyn, Peter, Owen, Jennifer, France, John, Reed, Bryony, Foulds, Angie, Richard, Bella, Parfitt, Louise, Affley, Brendan, Russo, Cristina, Dsouza, Margaret, Cruddas, Elizabeth, Hargroves, David, Rand, James, Shekar, Som, Bhat, Yaqoob, Marshall, Gail, Nash, Maxine, Ahmad, Nasar, Okoko, Blessing Oduh, Evans, Rachel, Taylor, Tegan, Dawson, Jesse, Colquhoun, Elizabeth, James, Christopher, Aguirre, Carlos, MacPhee, Catherine, Phipps, Janet, Ispoglou, Sissi, Hayes, Anne, and Evans, Rachel

Abstract

The optimal timing of anticoagulation for patients with acute ischaemic stoke with atrial fibrillation is uncertain. We investigated the efficacy and safety of early compared with delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischaemic stroke associated with atrial fibrillation.

Published
2024
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30. Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment

Author

AIOS Anesthesiologie, Opleiding Neurologie, Neurologen, Brain, Circulatory Health, Stroke, de Jonge, Jeroen C., Sluis, Wouter M., Reinink, Hendrik, Bath, Philip M., Woodhouse, Lisa J., Zweedijk, Berber, van de Beek, Diederik, Aamodt, Anne Hege, Alpers, Iris, Ciccone, Alfonso, Csiba, Laszlo, Demotes, Jacques, Kõrv, Janika, Kurkowska-Jastrzebska, Iwona, Dawson, Jesse, Macleod, Malcolm R., Ntaios, George, Poli, Sven, Milionis, Haralampos, Ricci, Stefano, Cenciarelli, Silvia, Candelaresi, Paolo, de Bruijn, Sebastiaan FTM, Pathansali, Rohan, Krishnan, Kailash, Clarke, Brian, Thomalla, Götz, van der Worp, H. Bart, Kwa, Vincent IH, Müller, Susanne, Protogerou, Athanasios D., the PRECIOUS investigators, AIOS Anesthesiologie, Opleiding Neurologie, Neurologen, Brain, Circulatory Health, Stroke, de Jonge, Jeroen C., Sluis, Wouter M., Reinink, Hendrik, Bath, Philip M., Woodhouse, Lisa J., Zweedijk, Berber, van de Beek, Diederik, Aamodt, Anne Hege, Alpers, Iris, Ciccone, Alfonso, Csiba, Laszlo, Demotes, Jacques, Kõrv, Janika, Kurkowska-Jastrzebska, Iwona, Dawson, Jesse, Macleod, Malcolm R., Ntaios, George, Poli, Sven, Milionis, Haralampos, Ricci, Stefano, Cenciarelli, Silvia, Candelaresi, Paolo, de Bruijn, Sebastiaan FTM, Pathansali, Rohan, Krishnan, Kailash, Clarke, Brian, Thomalla, Götz, van der Worp, H. Bart, Kwa, Vincent IH, Müller, Susanne, Protogerou, Athanasios D., and the PRECIOUS investigators

Published
2024

33. Stroke

Author

McFall, Aisling, Dawson, Jesse, Work, Lorraine M., Touyz, Rhian M., editor, and Delles, Christian, editor

Published
2019
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35. Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial

Author

ALTHAUS, Katharina, AMARO, Sergi, BAE, Hee-Joon, BAK, Zbigniew, BARBARINI, Leonardo, BASSI, Pietro, BAZAN, Rodrigo, BERECZKI, Daniel, BERKOWICZ, Tomasz, BERROUSCHOT, Joerg, BLACQUIERE, Dylan, BROLA, Waldemar, BUTCHER, Kenneth, CARDONA, Pere, CHA, Jae-Kwan, CLOUD, Geoffrey, COHEN, David, CORDONNIER, Charlotte, CSANYI, Attila, CZLONKOWSKA, Anna, DAVIS, Stephen, DAWSON, Jesse, DE KLIPPEL, Nina, DENIER, Christian, DESFONTAINES, Philippe, DIENER, Hans-Christoph, DIOSZEGHY, Peter, DIPPEL, Diederik Willem, DORADO, Laura, FOLYOVICH, Andras, FREITAS, Gabriel Rodriguez, FRIEDRICH, Mauricio Andre, FRYZE, Waldemar, GAGLIARDI, Rubens Jose, GOTTSCHAL, Marianna, GRIMLEY, Rohan, GROND, Martin, GRÖSCHEL, Klaus, HOSSEINI, Hassan, HWANG, Yangha, KALLMUENZER, Bernd, KHAN, Usman, KIM, Jong Sung, KLEINIG, Tim, KOVES, Agnes, LAGO MARTIN, Aida, LASEK-BAL, Anetta, LEMBO, Giuseppe, LEMMENS, Robin, LINDERT, Ralf, PORCELLO MARRONE, Luiz Carlos, MARTINEZ ZABALETA, Maite, MAS, Jean-Louis, MASJUAN VALLEJO, Jaime, MAZIGHI, Mikael, MINELLI, Cesar, MISTRI, Amit, MOLINA, Carlos, MONICHE ALVAREZ, Francisco, CABRAL MORO, Carla Heloisa, MULLENERS, Wim, NABAVI, Darius, NEAU, Jean-Philippe, O'BRIEN, Bill, OVARY, Csaba, PANCZEL, Gyula, PARK, Man Seok, PHAN, Thanh, RAGAB, Suzanne, REJDAK, Konrad, RODRIGUEZ DE FREITAS, Gabriel, ROFFE, Christine, ROQUER GONZALEZ, Jaume, ROVER, Luisa, SAMPAIO SILVA, Gisele, SCHELLINGER, Peter, SEGURA MARTIN, Tomas, SHAW, Louise, SIBON, Igor, SKODA, Ondrej, SMADJA, Didier, SOBOLEWSKI, Piotr, SODA, Hassan, SPRIGG, Nikola, SWIAT, Maciej, SZAPARY, Laszlo, SZEGEDI, Norbert, TONI, Danilo, VALIKOVICS, Attila, VANHOOREN, Geert, VECSEI, Laszlo, WEIN, Theodore, WONG, Andrew, XIMENEZ CARRILLO, Alvaro, Chabriat, Hugues, Bassetti, Claudio L, Marx, Ute, Audoli-Inthavong, Marie-Laure, Sors, Aurore, Lambert, Estelle, Wattez, Marine, and Hermann, Dirk M

Published
2020
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37. Safety, Feasibility, and Efficacy of Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Ischemic Stroke

Author

Dawson, Jesse, Pierce, David, Dixit, Anand, Kimberley, Teresa J, Robertson, Michele, Tarver, Brent, Hilmi, Omar, McLean, John, Forbes, Kirsten, Kilgard, Michael P, Rennaker, Robert L, Cramer, Steven C, Walters, Matthew, and Engineer, Navzer

Subjects
Physical Rehabilitation, Stroke, Rehabilitation, Neurosciences, Clinical Research, Clinical Trials and Supportive Activities, Brain Disorders, Adult, Aged, Brain Ischemia, Feasibility Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Muscle Weakness, Patient Safety, Pilot Projects, Recovery of Function, Single-Blind Method, Stroke Rehabilitation, Treatment Outcome, Upper Extremity, Vagus Nerve Stimulation, deglutition disorders, intention to treat analysis, rehabilitation, stroke, vagus nerve, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeRecent animal studies demonstrate that vagus nerve stimulation (VNS) paired with movement induces movement-specific plasticity in motor cortex and improves forelimb function after stroke. We conducted a randomized controlled clinical pilot study of VNS paired with rehabilitation on upper-limb function after ischemic stroke.MethodsTwenty-one participants with ischemic stroke >6 months before and moderate to severe upper-limb impairment were randomized to VNS plus rehabilitation or rehabilitation alone. Rehabilitation consisted of three 2-hour sessions per week for 6 weeks, each involving >400 movement trials. In the VNS group, movements were paired with 0.5-second VNS. The primary objective was to assess safety and feasibility. Secondary end points included change in upper-limb measures (including the Fugl-Meyer Assessment-Upper Extremity).ResultsNine participants were randomized to VNS plus rehabilitation and 11 to rehabilitation alone. There were no serious adverse device effects. One patient had transient vocal cord palsy and dysphagia after implantation. Five had minor adverse device effects including nausea and taste disturbance on the evening of therapy. In the intention-to-treat analysis, the change in Fugl-Meyer Assessment-Upper Extremity scores was not significantly different (between-group difference, 5.7 points; 95% confidence interval, -0.4 to 11.8). In the per-protocol analysis, there was a significant difference in change in Fugl-Meyer Assessment-Upper Extremity score (between-group difference, 6.5 points; 95% confidence interval, 0.4 to 12.6).ConclusionsThis study suggests that VNS paired with rehabilitation is feasible and has not raised safety concerns. Additional studies of VNS in adults with chronic stroke will now be performed.Clinical trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01669161.

Published
2016

38. Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis

Author

Lim, Soon Tjin, Thijs, Vincent, Murphy, Stephen J. X., Fernandez-Cadenas, Israel, Montaner, Joan, Offiah, Chika, Marquardt, Lars, Kelly, Peter J., Bath, Philip M., Lim, Su-Yin, Ford, Gary A., Norrving, Bo, Cox, Dermot, Prodan, Calin I., Barber, Philip A., Werring, David J., Perry, Richard, Zgaga, Lina, Dawson, Jesse, and McCabe, Dominick J. H.

Published
2020
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40. Early vs Late Anticoagulation in Minor, Moderate, and Major Ischemic Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial

Author

Goeldlin, Martina B., Hakim, Arsany, Branca, Mattia, Abend, Stefanie, Kneihsl, Markus, Valenzuela Pinilla, Waldo, Fenzl, Sabine, Rezny-Kasprzak, Beata, Rohner, Roman, Strbian, Daniel, Paciaroni, Maurizio, Thomalla, Goetz, Michel, Patrik, Nedeltchev, Krassen, Gattringer, Thomas, Sandset, Else Charlotte, Bonati, Leo, Aguiar de Sousa, Diana, Sylaja, P. N., Ntaios, George, Koga, Masatoshi, Gdovinova, Zuzana, Lemmens, Robin, Bornstein, Natan M., Kelly, Peter, Katan, Mira, Horvath, Thomas, Dawson, Jesse, and Fischer, Urs

Abstract

IMPORTANCE: Whether infarct size modifies the treatment effect of early vs late direct oral anticoagulant (DOAC) initiation in people with ischemic stroke and atrial fibrillation is unknown. OBJECTIVE: To assess whether infarct size modifies the safety and efficacy of early vs late DOAC initiation. DESIGN, SETTING, AND PARTICIPANTS: Post hoc analysis of participants from the multinational (>100 sites in 15 countries) randomized clinical Early Versus Later Anticoagulation for Stroke With Atrial Fibrillation (ELAN) trial who had (1) acute ischemic stroke, (2) atrial fibrillation, and (3) brain imaging available before randomization. The ELAN trial was conducted between October 2017 and December 2022. Data were analyzed from October to December 2023 for this post hoc analysis. INTERVENTION: Early vs late DOAC initiation after ischemic stroke. Early DOAC initiation was within 48 hours for minor or moderate stroke or on days 6 to 7 for major stroke; late DOAC initiation was on days 3 to 4 for minor stroke, days 6 to 7 for moderate stroke, and days 12 to 14 for major stroke. MAIN OUTCOMES AND MEASURES: The primary outcome was a composite of recurrent ischemic stroke, symptomatic intracranial hemorrhage, extracranial bleeding, systemic embolism, or vascular death within 30 days. The outcome was assessed according to infarct size (minor, moderate, or major) using odds ratios and risk differences between treatment arms. Interrater reliability for infarct size between the core laboratory and local raters was assessed, and whether this modified the estimated treatment effects was also examined. RESULTS: A total of 1962 of the original 2013 participants (909 [46.3%] female; median [IQR] age, 77 [70-84] years) were included. The primary outcome occurred in 10 of 371 participants (2.7%) with early DOAC initiation vs 11 of 364 (3.0%) with late DOAC initiation among those with minor stroke (odds ratio [OR], 0.89; 95% CI, 0.38-2.10); in 11 of 388 (2.8%) with early DOAC initiation vs 14 of 392 (3.6%) with late DOAC initiation among those with moderate stroke (OR, 0.80; 95% CI, 0.35-1.74); and in 8 of 219 (3.7%) with early DOAC initiation vs 16 of 228 (7.0%) with late DOAC initiation among those with major stroke (OR, 0.52; 95% CI, 0.21-1.18). The 95% CI for the estimated risk difference of the primary outcome in early anticoagulation was −2.78% to 2.12% for minor stroke, −3.23% to 1.76% for moderate stroke, and −7.49% to 0.81% for major stroke. There was no significant treatment interaction for the primary outcome. For infarct size, interrater reliability was moderate (κ = 0.675; 95% CI, 0.647-0.702) for local vs core laboratory raters and strong (κ = 0.875; 95% CI, 0.855-0.894) between core laboratory raters. CONCLUSIONS AND RELEVANCE: The treatment effect of early DOAC initiation did not differ in people with minor, moderate, or major stroke assessed by brain imaging. Early treatment was not associated with a higher rate of adverse events, especially symptomatic intracranial hemorrhage, for any infarct size, including major stroke. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03148457

Published
2024
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42. Outcomes in Patients With Poststroke Seizures

Author

Misra, Shubham, primary, Kasner, Scott E., additional, Dawson, Jesse, additional, Tanaka, Tomotaka, additional, Zhao, Yize, additional, Zaveri, Hitten P., additional, Eldem, Ece, additional, Vazquez, Juan, additional, Silva, Lucas Scárdua, additional, Mohidat, Saba, additional, Hickman, L. Brian, additional, Khan, Erum I., additional, Funaro, Melissa C., additional, Nicolo, John-Paul, additional, Mazumder, Rajarshi, additional, Yasuda, Clarissa Lin, additional, Sunnerhagen, Katharina S., additional, Ihara, Masafumi, additional, Ross, Joseph S., additional, Liebeskind, David S., additional, Kwan, Patrick, additional, Quinn, Terence J., additional, Engel, Jerome, additional, and Mishra, Nishant K., additional

Published
2023
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43. Control intervention design for preclinical and clinical trials: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable

Author

Hayward, Kathryn S, primary, Dalton, Emily J, additional, Barth, Jessica, additional, Brady, Marian, additional, Cherney, Leora R, additional, Churilov, Leonid, additional, Clarkson, Andrew N, additional, Dawson, Jesse, additional, Dukelow, Sean P, additional, Feys, Peter, additional, Hackett, Maree, additional, Zeiler, Steve R, additional, and Lang, Catherine E, additional

Published
2023
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44. Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials

Author

Krishnan, Kailash, primary, Campos, Paula Bermell, additional, Nguyen, Thanh N., additional, Tan, Chia Wei, additional, Chan, Siang Liang, additional, Appleton, Jason P., additional, Law, ZheKang, additional, Hollingworth, Milo, additional, Kirkman, Matthew A., additional, England, Timothy J., additional, Roffe, Christine, additional, Macleod, Mary Joan, additional, Dawson, Jesse, additional, Bayraktutan, Ulvi, additional, Werring, David J., additional, Sprigg, Nikola, additional, and Bath, Philip M., additional

Published
2023
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45. Natriuretic Peptides Improve Classification of People at Low Risk of Atrial Fibrillation after Stroke

Author

Cameron, Alan C, primary, Arnold, Markus, additional, Katsas, Georgios, additional, Yang, Jason, additional, Quinn, Terence, additional, Abdul-Rahim, Azmil H, additional, Campbell, Ross, additional, Docherty, Kieran, additional, De Marchis, Gian Marco, additional, Arnold, Marcel, additional, Kahles, Timo, additional, Nedeltchev, Krassen, additional, Cereda, Carlo, additional, Kaegi, Georg, additional, Bustamante, Alejandro, additional, Montaner, Joan, additional, Ntaios, George, additional, Foerch, Christian, additional, Spanaus, Katharina, additional, Von Eckardstein, Arnold, additional, Dawson, Jesse, additional, and Katan, Mira, additional

Published
2023
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46. Intima-media thickness at the near or far wall of the common carotid artery in cardiovascular risk assessment

Author

Seekircher, Lisa, primary, Tschiderer, Lena, additional, Lind, Lars, additional, Safarova, Maya S, additional, Kavousi, Maryam, additional, Ikram, M Arfan, additional, Lonn, Eva, additional, Yusuf, Salim, additional, Grobbee, Diederick E, additional, Kastelein, John J P, additional, Visseren, Frank L J, additional, Walters, Matthew, additional, Dawson, Jesse, additional, Higgins, Peter, additional, Agewall, Stefan, additional, Catapano, Alberico, additional, de Groot, Eric, additional, Espeland, Mark A, additional, Klingenschmid, Gerhard, additional, Magliano, Dianna, additional, Olsen, Michael H, additional, Preiss, David, additional, Sander, Dirk, additional, Skilton, Michael, additional, Zozulińska-Ziółkiewicz, Dorota A, additional, Grooteman, Muriel P C, additional, Blankestijn, Peter J, additional, Kitagawa, Kazuo, additional, Okazaki, Shuhei, additional, Manzi, Maria V, additional, Mancusi, Costantino, additional, Izzo, Raffaele, additional, Desvarieux, Moise, additional, Rundek, Tatjana, additional, Gerstein, Hertzel C, additional, Bots, Michiel L, additional, Sweeting, Michael J, additional, Lorenz, Matthias W, additional, and Willeit, Peter, additional

Published
2023
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48. Prevention of stroke : risk stratification and targeted and novel therapies

Author

Dawson, Jesse

Subjects
616.8, R Medicine (General), RM Therapeutics. Pharmacology
Abstract

Stroke is a common disorder with dire consequences for the patient and for society and will increase in prevalence over the coming years. Following stroke, many patients unfortunately suffer a further stroke, and recurrent strokes account for approximately 25% of the total. Considerable scope therefore exists to improve both primary and secondary stroke prevention. This thesis has addressed several areas at key stages in the prevention of stroke by developing strategies to better identify those at highest risk, attempting to better target pre-existing anti-platelet therapy and by beginning the evaluation of xanthine oxidase reduction and uric acid lowering therapy in the prevention of stroke. A clinical scoring system to aid diagnostic recognition in those with suspected transient ischaemic attack (TIA) was successfully developed and has the ability to reduce the referral of those without cerebrovascular disease to busy TIA clinics. The score was developed on data from 3216 patients and included 9 clinically useful predictive variables. After adjustment to reflect the greater seriousness of missing true TIA patients, 97% of TIA and 22% of non-TIA patients were accurately identified. The results were confirmed during prospective validation. Use of the score could have a substantial effect on waiting times for assessment; there is potential double the numbers seen within the timeframe recommended by guidelines with no other change to services. This would be an important advance given the recent evidence that rapid assessment and treatment of those with TIA greatly reduces stroke risk. Aspirin resistance was found to be higher in those with cerebrovascular microembolic signals (MES) and carotid disease compared to those with equivalent carotid disease and no MES. This study included sixty-two patients who mostly had symptomatic carotid disease. Approximately a quarter had MES. The rate of aspirin resistance on at least one test was 25.8% (16 patients), with 13 (21%) resistant on PFA-100 testing, 8 (12.9%) using the Verify-Now system and 5 (8.1%) resistant on both. Aspirin resistance was more common in patients with MES (50% compared to 17.4% without, p=0.018 on Fishers exact test). This provides a link to a well established and robust surrogate marker of outcome and thus a useful model to further study the benefits of guided anti-platelet strategies. An interventional clinical anti-platelet trial based upon individual aspirin responsiveness in high risk individuals such as those with MES is now warranted. Aspirin resistance was also confirmed to be a common phenomenon in a case-control study of 180 patients. It was present in 34% of those with recent stroke and in 18% of those with risk factors but no established disease. However, the role of poor compliance with therapy as a cause in a substantial number of cases was established; it accounted for approximately half of those labelled resistant in the stroke group. Further, when only those with objective evidence of recent aspirin ingestion were considered, the prevalence of aspirin resistance was similar in both groups (at 26%). This suggests that objective measures to confirm compliance with aspirin therapy should be mandatory in future studies of aspirin resistance. Increasing serum uric acid was found to be a predictor of poor functional outcome following acute stroke but not in an independent fashion. In total, 852 patients were included in this study and greater uric acid levels were associated with increased odds of poor outcome on univariate but not multivariate analysis (OR 1.3, 95% CI 0.73-2.31). However, there was no evidence of an association with favourable outcome as other groups have found. Increasing serum uric acid was also shown to be predictive of increased risk of stroke, total, vascular and coronary mortality in treated hypertensive patients but interestingly, the relationship between stroke mortality and serum uric acid appears J-shaped and most apparent in females. A study of the use of allopurinol in those with diabetes showed that xanthine oxidase inhibition improves cerebral nitric oxide bioavailability suggesting a beneficial effect of allopurinol on cerebrovascular health. This study included 14 participants who had impaired baseline cerebrovascular nitric oxide bioavailability. Allopurinol led to a significant improvement in responses to NG-monomethyl-L-arginine (L-NMMA) when compared to placebo (p=0.032, median improvement in ICA flow reduction following L-NMMA of 3144 (95% CI 375 to 7143)) mls). L-NMMA is an inhibitor of endothelial nitric oxide synthase which reduces cerebral blood flow in healthy volunteers; the bigger the reduction, the greater the endothelial health. However, a study of the effect of allopurinol treatment on cerebrovascular reactivity (as measured by response to acetazolamide infusion) in a group of patients with recent subcortical stroke revealed no positive effect. Cerebrovascular reactivity was unchanged by treatment with allopurinol. This raises interesting questions regarding the longevity of any positive effect of allopurinol as this, and other studies of 3 month duration, have revealed no benefit. Further, subjects in this study did not, on balance, have elevated serum uric acid and it has recently been suggested that only those with significantly elevated levels benefit in the setting of congestive cardiac failure. Whether this is also true in those with stroke also requires to be clarified. A large study of the effect of allopurinol on carotid intima-media thickness, a robust and modifiable marker of vascular risk, in those with recent stroke is planned to address these questions. The studies in this thesis therefore include a number of pragmatic findings which could improve care at all stages in the prevention of stroke. The TIA scoring system could improve recognition of the high risk condition TIA, a useful model has been developed in which to study a population of patients truly resistant to aspirin and important lessons have been learned to aid further evaluation of xanthine oxidase inhibition; a promising therapy for the prevention of stroke.

Published
2009

49. Risk Factors for Intracerebral Hemorrhage in Patients With Atrial Fibrillation on Non–Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Giustozzi, Michela, Caso, Valeria, Toso, Elisabetta, Angelini, Filippo, Canavero, Isabella, Micieli, Giuseppe, Antonenko, Kateryna, Rocco, Alessandro, Diomedi, Marina, Katsanos, Aristeidis H., Shoamanesh, Ashkan, Giannopoulos, Sotirios, Ageno, Walter, Pegoraro, Samuela, Putaala, Jukka, Strbian, Daniel, Sallinen, Hanne, Mac Grory, Brian C., Furie, Karen L., Stretz, Christoph, Reznik, Michael E., Alberti, Andrea, Venti, Michele, Mosconi, Maria Giulia, Vedovati, Maria Cristina, Franco, Laura, Zepponi, Giorgia, Romoli, Michele, Zini, Andrea, Brancaleoni, Laura, Riva, Letizia, Silvestrelli, Giorgio, Ciccone, Alfonso, Zedde, Maria Luisa, Giorli, Elisa, Kosmidou, Maria, Ntais, Evangelos, Palaiodimou, Lina, Halvatsiotis, Panagiotis, Tassinari, Tiziana, Saia, Valentina, Ornello, Raffaele, Sacco, Simona, Bandini, Fabio, Mancuso, Michelangelo, Orlandi, Giovanni, Ferrari, Elena, Pezzini, Alessandro, Poli, Loris, Cappellari, Manuel, Forlivesi, Stefano, Rigatelli, Alberto, Yaghi, Shadi, Scher, Erica, Frontera, Jennifer A., Masotti, Luca, Grifoni, Elisa, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Marcheselli, Simona, Gasparro, Antonio, Terruso, Valeria, Arnao, Valentina, Aridon, Paolo, Abdul-Rahim, Azmil H., Dawson, Jesse, Saggese, Carlo Emanuele, Palmerini, Francesco, Doronin, Boris, Volodina, Vera, Toni, Danilo, Risitano, Angela, Schirinzi, Erika, Del Sette, Massimo, Lochner, Piergiorgio, Monaco, Serena, Mannino, Marina, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Lotti, Enrico Maria, Padroni, Marina, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Ntaios, George, Sagris, Dimitrios, Baldi, Antonio, D’Amore, Cataldo, Mumoli, Nicola, Porta, Cesare, Denti, Licia, Chiti, Alberto, Corea, Francesco, Acciarresi, Monica, Flomin, Yuriy, Popovic, Nemanja, and Tsivgoulis, Georgios

Published
2021
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50. Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials

Author

Gill, Dipender, Cameron, Alan C., Burgess, Stephen, Li, Xue, Doherty, Daniel J., Karhunen, Ville, Abdul-Rahim, Azmil H., Taylor-Rowan, Martin, Zuber, Verena, Tsao, Philip S., Klarin, Derek, Evangelou, Evangelos, Elliott, Paul, Damrauer, Scott M., Quinn, Terence J., Dehghan, Abbas, Theodoratou, Evropi, Dawson, Jesse, and Tzoulaki, Ioanna

Published
2021
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