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Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial
Authors :
Werring, David J Dehbi, Hakim-Moulay Ahmed, Norin Arram, Liz Best, Jonathan G Balogun, Maryam Bennett, Kate Bordea, Ekaterina Caverly, Emilia Chau, Marisa Cohen, Hannah Cullen, Mairead Doré, Caroline J Engelter, Stefan T Fenner, Robert Ford, Gary A Gill, Aneet Hunter, Rachael James, Martin Jayanthi, Archana Lip, Gregory Y H Massingham, Sue Murray, Macey L Mazurczak, Iwona Nash, Philip S Ndoutoumou, Amalia Norrving, Bo Sims, Hannah Sprigg, Nikola Vanniyasingam, Tishok Freemantle, Nick Jelley, Benjamin Hughes, Tom Evans, Mim Esteban, Diego Garcia Knibbs, Lucy Broad, Lauren Price, Rebecca Griebel, Liz Hamer Hewson, Sian Thavanesan, Kamy Mallon, Louise Smith, Anna White, Miranda Zhang, Liqun Clarke, Brian Abousleiman, Youssif Binnie, Lauren Sim, Cai Hua Castanheira, Margarida Humphries, Fiona Obarey, Sabaa Feerick, Shez Lee, Yee Chin Lewis, Alex Muhammad, Riham Francia, Nina Atang, Ndifreke Banaras, Azra Marinescu, Marilena Ferdinand, Philip Varquez, Resti Ponce, Ida Saxena, Surabhi O'Brien, Eoin Reyes, Juliana Delos Mitchell-Douglas, Jennifer Francis, Jobbin Banerjee, Soma Dave, Vaishali Mashate, Sheila Patel, Tulsi Sekaran, Lakshmanan Murad, Wahid Asaipillai, Asokanathan Sakthivel, Sethuraman Tate, Margaret Angus, Jane Reid, Lisa Fornolles, Caroline Sundayi, Saul Poolon, Lincy Justin, Francis Hunte, Sophy Bhandari, Mohit Kho, Jules Cvoro, Vera Parakramawansha, Ruwan Couser, Mandy Hughes, Hannah Naqvi, Aaizza Harkness, Kirsty Richards, Emma Howe, Jo Kamara, Chris Gardner, Jon Bains, Harjit Teal, Rachel Joseph, Jeethu Benjamin, Jithen Al-Hussayni, Samer Thomas, George Robinson, Faye Dixon, Lynn Krishnan, Manju Slade, Peter Anjum, Tal Storton, Sharon Adie, Katja Northcott, Keren Morgan, Katie Williams, Emilie Chanashekar, Harinath Maguire, Holly Gabriel, Claire Maren, Deborah David, Hannah Clarke, Sheron Nagaratnam, Kiruba Nelatur, Varun Mannava, Neelima Blasco, Lara Devine, Joseph Bathula, Rajaram Gopi, Parvathy Mehta, Niharika Sreedevi Raj, Sreena Teo, James Sztriha, Laszio Mah, Yee Ankolekar, Sandeep Sari, Beatrix Tibajai, Maria Morgan, Alicia Recaman, Maria Bayhonan, Samantha Belo, Caroline Finch, Sharon Keenan, Samantha Bowring, Angie Shetty, Ashit Chan, Siang Gray, Lucy Harrison, Thomas Spooner, Oliver Kinsella-Perks, Edward Erumere, Esther Sanders, Brittany Sims, Don Willmot, Mark Littleton, Edward Spruce, Elaine Moody, Lisa Sheriden, Christopher Luxmore-Brown, Scott Neal, Aoife Beddows, Sophie Tuna, Maria Assuncao Misra, Amulya Penn, Ruth Mariampillai, Sonia Anwar, Ijaz Annamalai, Arunkumar Whitehouse, Sarah Shepherd, Lorna Siddle, Elaine Chatterjee, Kausik Leason, Sandra Davies, Angela Marigold, Richard James Frank, Sarah Baird, Alix Hannam-Penfold, Tomas Inacio, Liliana Smith, Simon Eveson, David Musarrat, Kashif Khan, Shagufta Harris, Tracy Chowdhury, Muhibbur Alam, Sajid Jamieson, Elena Anyankpele, Ebitare Al Shalchi, Farah Rivers, Vanessa Bell, Stephanie Francis, Rebecca Beeby, Deborah Finch, Jenny Macleod, Mary Joan Guzman-Gutierrez, German Carter, Karla Irvine, Janice Gbadamoshi, Lukuman Costa, Telma Heirons, Sarah Stoney, Hayley Shaw, Louise Choulerton, James Catibog, Darwin Sattar, Naweed Myint, Min Smith, Andy Serac, Kwin Emsley, Hedley Sultan, Sulaiman Gregary, Bindu Brown, Allan Mahmood, Afzal Chattha, Navraj Old, William Pegg, Claire Davey, Miriam Page, Michelle Sandhu, Banher Phiri, Emily Rashed, Khalid Wilson, Elisabeth Hindley, Esther Board, Sarah Antony, Sherly Tanate, Alfonso Davis, Michelle Holland, Beth Slater, Victoria Fawcett, Michelle England, Tim Scott, James Beavan, Jessica Hedstrom, Amanda Karunatilake, Dumin Gillmain, Kimberley Singh, Nishy Hallows, Tracy Barber, Mark Yates, Luke Micallef, Clayton Esson, Derek Meng Yu, Wai Ming New, Benjamin Jaa Matos, Alexandre Burt, Clare Cabrelli, Louise Wilkie, Gillian Meegada, Madana Kirthivasan, Ramanathan Fox, Caroline Mead, Victoria Lyle, Amanda Saksena, Rajesh Bakshi, Aashima O'Kelly, Alison Rehan, Jahanzeb Ebueka, Osaretin Cooper, Martin Wynter, Inez Smith, Susan Kumar, Senthil O'Brien, Linda Parker, Cerrys Parker, Emma Khan, Numan Patterson, Christopher Maguire, Stuart Quinn, Outi Bellfield, Ruth Behnam, Yousif Costa, Janet Padilla-Harris, Cheryl Moram, Louise Raza, Syed Abid Tench, Helen Sims, Tanya McGuinness, Heather Loosley, Ronda Wolf-Roberts, Rebecca Buddha, Sandeep Salt, Irmak Lewis, Kerry Mavinamne, Sunanda Ditchfield, Coleen Dealing, Sharon Shah, Alexander Crossingham, Ginette Mwadeyi, Memory Kenton, Anthony Omoregie, Faith Abubakar, Saidu Warwick, Allison Hector, Gemma Hassan, Ahamad Veraque, Emelda Farman, Michelle Makawa, Linetty Byrne, Anthony Kirkham, Jackie Blayney, Gareth Selwyn, Jey Kakar, Puneet Al Khaddour, Mohammed Dhami, Reena Baker, Emelda Esisi, Bernard Clarkson, Emma Fellowes, Dominic Kresmir, Jergovic Guyler, Paul Ngo, David Wijenayake, Indunil Tysoe, Sharon Galliford, Joanne Harman, Paula Garside, Mark Badanahatti, Madhava Smith, Anna Riddell, Victoria Gramizadeh, Gita Dutta, Dipankar Bajoriene, Milda Erdogan, Hulya Ward, Deborah Doubal, Fergus Samarasekera, Neshika Risbridger, Sarah MacRaild, Allan Azim, Abul Wood, Lisa Tampset, Ruth Shekhar, Raj Rai, Umesh Fuller, Tracy Joshy, Aricsa Nadar, Evelyn Kini, Manohar Ahmad, Syed Robinson, Matthew King, Lucia Srinivasan, Venkatesan Karwacka-Cichomska, Magdalena Moore, Vicki Smith, Kate Kariyadil, Bincy Kong, Kelvin Hubbard, Kelly Arif, Sarwat Hasan, Muhammad Temple, Natalie Arcoria, Daniele Horne, Zoey Soe, Thandar Wyllie, Hilary Hacon, Christian Sutherland, Helen Menezes, Brian Johnson, Venetia Smyth, Nigel Mehdi, Zehra Tone, Ela Bradley, Arian Levell, Emma Ekkert, Aleksandra Mazzucco, Sara McCafferty, Laura Vonoven, Linda Dewan, Suprita Sridhar, Pagadala Thomas, Jayne Coetzee, Samantha Icke, Becky Williams, Jill Saravanan, Narayanamoorthi Bradley, Pamela Gibson, Rebecca Marie Antony, Jijimol Ashraf, Imran Mabuti, Jose Kamundi, Charlotte Patiola, Prasanna Oakley, Naomi Proeschel, Harold Kelly, Debs Longley, Wendy Cave, Ashleigh Ambrico, Carla Black, Toby Porretta, Elisa Anthony, Alpha Ragab, Suzanne Dube, Judith Kausar, Shahid Gujjar, Abdullah Abdullah, Mohammad Kaur, Daljit Gadapa, Naveen Choudhary, Sumita Nisar, Nabeela Fawehinmi, Grace Dunne, Karen King, Sam Kishore, Amit Lee, Stephanie Marsden, Tracy Slaughter, Melanie Cawley, Kathryn Perez, Jane Anderton, Peter Soussi, Salem Walstow, Deborah Pugh, Rebecca Manoj, Aravind Fletcher, Glynn Lopez, Paula McCormick, Michael Magee, Michael Tallon, Grainne McFarland, Denise Cosgrove, Denise Shinh, Naval Metcalf, Kneale Kostyuk, Alina McDonald, Susan Sayers, Sophie Sayed, Walee Abraham, Sam Szabo, Gemma Crosbie, Gareth McIlmoyle, Jim Fearon, Patricia Courtney, Kerry Tauro, Suzanne Singh, Arun Nair, Anand Duberley, Stephen Philip, Sheeba Curley, Cath Goddard, Wendy Bridge, Luke Willcoxson, Paul Wanklyn, Peter Owen, Jennifer France, John Reed, Bryony Foulds, Angie Richard, Bella Parfitt, Louise Affley, Brendan Russo, Cristina Dsouza, Margaret Cruddas, Elizabeth Hargroves, David Rand, James Shekar, Som Bhat, Yaqoob Marshall, Gail Nash, Maxine Ahmad, Nasar Okoko, Blessing Oduh Evans, Rachel Taylor, Tegan Dawson, Jesse Colquhoun, Elizabeth James, Christopher Aguirre, Carlos MacPhee, Catherine Phipps, Janet Ispoglou, Sissi Hayes, Anne Evans, Rachel
Source :
The Lancet; November 2024, Vol. 404 Issue: 10464 p1731-1741, 11p
Publication Year :
2024
Abstract
The optimal timing of anticoagulation for patients with acute ischaemic stoke with atrial fibrillation is uncertain. We investigated the efficacy and safety of early compared with delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischaemic stroke associated with atrial fibrillation.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
404
Issue :
10464
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs67813157
Full Text :
https://doi.org/10.1016/S0140-6736(24)02197-4