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1. Validation of a modified 28-day rat study to evidence effects of test compounds on the immune system.

Author

Richter-Reichhelm HB, Dasenbrock CA, Descotes G, Emmendörffer AC, Ernst HU, Harleman JH, Hildebrand B, Küttler K, Rühl-Fehlert CI, and Schilling K

Subjects
Animals, Female, Hemolytic Plaque Technique, Humans, Immune System pathology, Immunoglobulin G biosynthesis, Immunoglobulin G blood, Immunoglobulin G drug effects, Immunoglobulin M biosynthesis, Immunoglobulin M blood, Immunoglobulin M drug effects, Immunophenotyping, Kidney drug effects, Kidney pathology, Killer Cells, Natural immunology, Liver drug effects, Liver pathology, Lymphocyte Activation drug effects, Lymphoid Tissue drug effects, Lymphoid Tissue pathology, Macrophage Activation drug effects, Male, Mitogens pharmacology, Rats, Rats, Wistar, Cyclosporine toxicity, Immune System drug effects, Toxicity Tests standards
Published
1995
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