101 results on '"Daniel Macias"'
Search Results
2. Annihilating class groups in $p$-elementary extensions
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Bullach, Dominik and Castillo, Daniel Macias
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Mathematics - Number Theory ,11R29, 11R42 - Abstract
We derive new cases of conjectures of Rubin and of Burns--Kurihara--Sano concerning derivatives of Dirichlet $L$-series at $s = 0$ in $p$-elementary extensions of number fields for arbitrary prime numbers $p$. In naturally arising examples of such extensions one therefore obtains annihilators of class groups from $S$-truncated Dirichlet $L$-series for `large-enough' sets of places $S$.
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- 2023
3. The refined class number formula for Drinfeld modules
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de Frutos-Fernández, María Inés, Castillo, Daniel Macias, and Marqués, Daniel Martínez
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Mathematics - Number Theory - Abstract
Let $K/k$ be a finite Galois extension of global function fields. Let $E$ be a Drinfeld module over $k$. We state and prove an equivariant refinement of Taelman's analogue of the analytic class number formula for $(E,K/k)$, and derive explicit consequences for the Galois structure of the Taelman class group of $E$ over $K$., Comment: 41 pages
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- 2023
4. Numerical Evidence for a refinement of Deligne's Period Conjecture for Jacobians of Curves
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Evans, Robert, Castillo, Daniel Macias, and Wiersema, Hanneke
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Mathematics - Number Theory ,11G10, 11G40 (primary), 11G30, 11G35 (secondary) - Abstract
Let $A/\mathbb{Q}$ be a Jacobian variety and let $F$ be a totally real, tamely ramified, abelian number field. Given a character $\psi$ of $F/\mathbb{Q}$, Deligne's Period Conjecture asserts the algebraicity of the suitably normalised value $\mathcal{L}(A,\psi,1)$ at $z=1$ of the Hasse-Weil-Artin $L$-function of the $\psi$-twist of $A$. We formulate a conjecture regarding the integrality properties of the family of normalised $L$-values $(\mathcal{L}(A,\psi,1))_{\psi}$, and its relation to the Tate-Shafarevich group of $A$ over $F$. We numerically investigate our conjecture through $p$-adic congruence relations between these values., Comment: 24 pages
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- 2023
5. Fuzzy-Bayesian Expert System for Assistance in Bike Mechanical Issues
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Escobar, Roberto Macías, Montes Rivera, Martín, Escobar, Daniel Macias, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Calvo, Hiram, editor, Martínez-Villaseñor, Lourdes, editor, Ponce, Hiram, editor, Zatarain Cabada, Ramón, editor, Montes Rivera, Martín, editor, and Mezura-Montes, Efrén, editor
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- 2024
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6. Fuzzy-Bayesian Expert System for Assistance in Bike Mechanical Issues
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Escobar, Roberto Macías, primary, Montes Rivera, Martín, additional, and Escobar, Daniel Macias, additional
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- 2024
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7. On Weil-Stark elements, I: general properties
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Burns, David, Castillo, Daniel Macias, and Seo, Soogil
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Mathematics - Number Theory - Abstract
We construct a canonical family of elements in the reduced exterior power lattices of the unit groups of global fields. We prove that this family recovers the theory of cyclotomic elements in real abelian fields and also establish detailed arithmetic properties of its elements in the general case., Comment: This is part I of a split article; 25 pages
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- 2021
8. Congruences for critical values of higher derivatives of twisted Hasse-Weil L-functions, III
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Bley, Werner and Castillo, Daniel Macias
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Mathematics - Number Theory - Abstract
Let $A$ be an abelian variety defined over a number field $k$, let $p$ be an odd prime number and let $F/k$ be a cyclic extension of $p$-power degree. Under not-too-stringent hypotheses we give an interpretation of the $p$-component of the relevant case of the equivariant Tamagawa number conjecture in terms of integral congruence relations involving the evaluation on appropriate points of $A$ of the ${\rm Gal}(F/k)$-valued height pairing of Mazur and Tate. We then discuss the numerical computation of this pairing, and in particular obtain the first numerical verifications of this conjecture in situations in which the $p$-completion of the Mordell-Weil group of $A$ over $F$ is not a projective Galois module., Comment: Final version, 26 pages. To appear in Math. Proc. Camb. Phil. Soc
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- 2019
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9. On non-abelian higher special elements of $p$-adic representations
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Castillo, Daniel Macias and Tsoi, Kwok-Wing
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Mathematics - Number Theory - Abstract
We develop a theory of `non-abelian higher special elements' in the non-commutative exterior powers of the Galois cohomology of $p$-adic representations. We explore their relation to the theory of organising matrices and thus to the Galois module structure of Selmer modules. In concrete applications, we relate our general theory to the formulation of refined conjectures of Birch and Swinnerton-Dyer type and to the Galois structure of Tate-Shafarevich and Selmer groups of abelian varieties., Comment: Updated References
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- 2019
10. On refined conjectures of Birch and Swinnerton-Dyer type for Hasse-Weil-Artin L-series
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Burns, David and Castillo, Daniel Macias
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Mathematics - Number Theory ,Mathematics - Algebraic Geometry - Abstract
We consider refined conjectures of Birch and Swinnerton-Dyer type for the Hasse-Weil-Artin L-series of abelian varieties over general number fields. We shall, in particular, formulate several new such conjectures and establish their precise relation to previous conjectures, including to the relevant special case of the equivariant Tamagawa number conjecture. We also derive a wide range of concrete interpretations and explicit consequences of these conjectures that, in general, involve a thoroughgoing mixture of difficult archimedean considerations related to refinements of the conjecture of Deligne and Gross and delicate p-adic congruence relations that involve the bi-extension height pairing of Mazur and Tate and are related to key aspects of non-commutative Iwasawa theory. In important special cases we provide strong evidence, both theoretical and numerical, in support of the conjectures. We also point out an inconsistency in a conjecture of Bradshaw and Stein regarding Zhang's Theorem on Heegner points and suggest a possible correction., Comment: Revised in accordance to referees' suggestions, 142 pages
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- 2019
11. On non-abelian higher special elements of p-adic representations
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Castillo, Daniel Macias and Tsoi, Kwok-Wing
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- 2022
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12. Neurological presentations of COVID-19: Findings from the Spanish Society of Neurology neuroCOVID-19 registry
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Fernández, Alejandra Collía, Horga, Alejandro, Prieto, Ana Barragán, del Villar Igea, Ana, Núñez, Ana Urbanos, Serrano, Ángel Aledo, García, Araceli, Menéndez, Beatriz Martínez, Recasens, Bernat Bertran, Serrano, Blanca Serrano, de la Esperanza, Blanca Talavera, de la Hoz, Carlos Pablo de Fuenmayor Fernández, Juste, Carlos Tejero, Martín, Carmen Valderrama, García, Cristina Fernández, Ochoa, Marta, Íñiguez, Cristina, García, Daniel Macías, Pérez Martínez, David A., Santacruz, Débora Mª. Cerdán, Robert, Misericòrdia Floriach, Gomez, Elisabet Franquet, Puiggròs, Elsa, Álvarez, Eric Freire, Llamas, Esteban Peña, Villareal, Estibaliz, Díaz, Eva Fernández, Burguillos, Fernando Morejón, Beitia, Garazi Agirre, Gutiérrez-Gutiérrez, Gerardo, Monteiro, Guilherme Carvalho, Ygual, Guillermo Cervera, Hernández, Guillermo, Rubio, Guillermo, Alonso, Hortenia, Froiz, Iago Payo, García, Iago Rego, Peñas, Inmaculada Redondo, Pérez Sánchez, Javier R., García, Javier Tejada, Álvarez, Javier Villacieros, Domínguez, Jéssica Fernández, Etessam, Jesús Porta, Equiza, Jon, Pascual, Jorge Millán, Usieto, José Antonio Oliván, Reyes, José Antonio, Gómez, José Balseiro, Bueno, José Carlos Roche, Velasquez, Jose Luis Camacho, López, José María Barrios, Raquel Lamas, Leire Ainz, Lezama, Lidia Binela Lara, Caballero, Lorena, Davila, Lucía Galan, González, Nuria, de Antonio, Luis Alberto Rodríguez, Torres, Mª. Araceli García, Zabaleta, Maite Martinez, Rodríguez, Manuel Medina, Moragues, María Dolores, García, María Fuensanta Valero, Hernández, María, Abildúa, María José Abenza, Rabasa, María, Santos, María Rico, Usero, María, Zurdo, Martín, Más, Miguel, Maneiro, Miren, Platas, Montserrat González, Muriana, Nafría, Noelia González, Esteve, Oriol Barrachina, del Saz Saucedo, Pablo, Rocío, Vilar Ventura, Rosa M., Atienza, Saida, Navas, Sandra Rodríguez, Fernández, Santiago Fernández, Borja, Sergio, Navarro, Silvia Gil, García, Solange Kapetanovic, García, Susana, Salas, Teresa Mateos, Palasí, Toni, Cantero, Victoriano Romero, García-Azorín, David, Aguirre, María Elena Erro, Moncó, Juan Carlos García, Guijarro-Castro, Cristina, Delgado, Fernando Romero, Andrés, José Miguel Láinez, and Ezpeleta, David
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- 2021
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13. On the Galois structure of Selmer groups
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Burns, David, Castillo, Daniel Macias, and Wuthrich, Christian
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Mathematics - Number Theory - Abstract
Let A be an abelian variety defined over a number field k and F a finite Galois extension of k. Let p be a prime number. Then under certain not-too-stringent conditions on A and F we investigate the explicit Galois structure of the p-primary Selmer group of A over F. We also use the results so obtained to derive new bounds on the growth of the Selmer rank of A over extensions of k.
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- 2015
14. On Mordell-Weil groups and congruences between derivatives of twisted Hasse-Weil L-functions
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Burns, David, Castillo, Daniel Macias, and Wuthrich, Christian
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Mathematics - Number Theory - Abstract
Let A be an abelian variety defined over a number field k and let F be a finite Galois extension of k. Let p be a prime number. Then under certain not-too-stringent conditions on A and F we compute explicitly the algebraic part of the p-component of the equivariant Tamagawa number of the pair ( h^1(A/F)(1), Z[Gal(F/k)] ). By comparing the result of this computation with the theorem of Gross and Zagier we are able to give the first verification of the p-component of the equivariant Tamagawa number conjecture for an abelian variety in the technically most demanding case in which the relevant Mordell-Weil group has strictly positive rank and the relevant field extension is both non-abelian and of degree divisible by p. More generally, our approach leads us to the formulation of certain precise families of conjectural p-adic congruences between the values at s=1 of derivatives of the Hasse-Weil L-functions associated to twists of A, normalised by a product of explicit equivariant regulators and periods, and to explicit predictions concerning the Galois structure of Tate-Shafarevich groups. In several interesting cases we provide theoretical and numerical evidence in support of these more general predictions.
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- 2015
15. Congruences for critical values of higher derivatives of twisted Hasse-Weil L-functions
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Bley, Werner and Castillo, Daniel Macias
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Mathematics - Number Theory - Abstract
Let A be an abelian variety over a number field k and F a finite cyclic extension of k of p-power degree for an odd prime p. Under certain technical hypotheses, we obtain a reinterpretation of the equivariant Tamagawa number conjecture (eTNC) for A, F/k and p as an explicit family of p-adic congru- ences involving values of derivatives of the Hasse-Weil L-functions of twists of A, normalised by completely explicit twisted regulators. This reinterpretation makes the eTNC amenable to numerical verification and furthermore leads to explicit predictions which refine well-known conjectures of Mazur and Tate.
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- 2014
16. On Refined Conjectures of Birch and Swinnerton-Dyer type for Hasse--Weil--Artin L-Series.
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Burns, David and Castillo, Daniel Macias
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- 2024
- Full Text
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17. Functional Movement Disorders and Deep Brain Stimulation: A Multi‐Center Study
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Luca Marsili, Elizabeth G. Keeling, Ricardo Maciel, Maria Fiorella Contarino, Rodi Zutt, Michael S. Okun, Leonardo Almeida, Wissam Deeb, Drew Kern, Daniel Macias‐Garcia, Fatima Carrillo, Pablo Mir, Aristide Merola, Alberto J. Espay, and Alfonso Fasano
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surgery ,Neurology ,functional movement disorders ,Neurology (clinical) ,deep brain stimulation - Abstract
Background: Functional movement disorders (FMD) are a commonly under-recognized diagnosis in patients with underlying neurodegenerative diseases. FMD have been observed in patients undergoing deep brain stimulation (DBS) for Parkinson's disease (PD) and other movement disorders. The prevalence of coexisting FMD among movement disorder-related DBS patients is unknown, and it may occur more often than previously recognized. Methods: We retrospectively assessed the relative prevalence and clinical characteristics of FMD occurring post-DBS, in PD and dystonia patients (FMD+, n = 29). We compared this cohort with age at surgery-, sex-, and diagnosis-matched subjects without FMD post-DBS (FMD-, n = 29). Results: Both the FMD prevalence (0.2%-2.1%) and the number of cases/DBS procedures/year varied across centers (0.15-3.65). A total of nine of 29 FMD+ cases reported worse outcomes following DBS. Although FMD+ and FMD- manifested similar features, FMD+ showed higher psychiatric comorbidity. Conclusions: DBS may be complicated by the development of FMD in a subset of patients, particularly those with pre-morbid psychiatric conditions.
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- 2022
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18. Heat transfer and chemical kinetics analysis of a novel solar reactor for hydrothermal processing
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Manira Elena Narvaez Saucedo, Camilo A. Arancibia-Bulnes, Juan Daniel Macias, Manuel Alejandro Ramirez-Cabrera, and Patricio J. Valades-Pelayo
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Renewable Energy, Sustainability and the Environment ,General Materials Science - Published
- 2022
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19. Smoking is associated with age at disease onset in Parkinson's disease
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Irene Rosas, Germán Morís, Eliecer Coto, Marta Blázquez-Estrada, Esther Suárez, Ciara García-Fernández, Carmen Martínez, Israel Duarte Herrera, Sergio Pérez-Oliveira, Victoria Álvarez, Manuel Menéndez-González, Astrid D. Adarmes-Gómez, Miquel Aguilar, Ignacio Alvarez, Francisco Javier Barrero, Jesús Alberto Bergareche Yarza, Marta Bonilla-Toribio, Juan A. Botía, María Teresa Boungiorno, Dolores Buiza-Rueda, Ana Cámara, Fátima Carrillo, Debora Cerdan, Jordi Clarimón, Yaroslau Compta, Monica Diez-Fairen, Oriol Dols-Icardo, Oriol de Fabregues, Pilar Sanz Cartagena, Jacinto Duarte, Raquel Duran, Francisco Escamilla-Sevilla, Mario Ezquerra, Cici Feliz, Rubén Fernández-Santiago, Manel Fernández, Pedro García-Ruiz, Pilar Gómez-Garre, Maria Jose Gomez Heredia, Isabel Gonzalez-Aramburu, Ana Gorostidi, Janet Hoenicka, Jon Infante, Silvia Jesús, Adriano Jimenez-Escrig, Jaime Kulisevsky, Miguel A. Labrador-Espinosa, Jose Luis Lopez-Sendon, Adolfo López de Munain, Daniel Macias-Garcia, Irene Martínez-Torres, Juan Marín, Maria Jose Marti, Juan Carlos Martínez-Castrillo, Marina Mata Álvarez-Santullano, Adolfo Mínguez-Castellanos, Pablo Mir, Elisabet Mondragon Rezola, Esteban Muñoz, Javier Pagonabarraga, Pau Pastor, Francisco Perez Errazquin, Maria Teresa Periñán, Javier Ruiz-Martínez, Clara Ruz, Antonio Sanchez Rodriguez, María Sierra, Cesar Tabernero, Juan Pablo Tartari, Eduard Tolosa, Francesc Valldeoriola, Lydia Vela, Francisco Vives, Berta Pascual-Sedano, Jorge Hernández-Vara, Dolores Vilas Rolán, Sara Bandrés-Ciga, Fundación José Luis Castaño, Obra Social Cajastur, European Commission, and Asociación Parkinson Asturias
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Cohort Studies ,Male ,Heterozygote ,Apolipoproteins E ,Neurology ,Smoking ,Humans ,Parkinson Disease ,Neurology (clinical) ,Age of Onset ,Geriatrics and Gerontology ,APOE - Abstract
[Background] Previous studies linked disease-progression variables such as age at onset or survival to both genetic, and non-genetic factors in Parkinson's disease (PD) patients., [Objective] The aim of this study was to assess how genetic and non genetic factors act as modifiers of age at onset and survival and in a cohort of 753 PD patients, and to determine how these variables interact to define the overall risk., [Methods] We analyzed the effect of gender, tobacco, alcohol, type of PD (genetic, gPD or idiopathic, iPD) and three genetic variants rs5848- GRN, rs1042522- TP53 and APOE. We studied two cohorts (PPMI and IPDGC) to replicate positive results., [Results] Regarding age at onset, male smokers PD had a significantly lower mean age compared to non-smoker (p = 0.001). APOE-Ɛ4 carriers had a younger onset-age compared to non-carriers (p = 0.03) in the Spanish cohort, but these results were not replicated in the other cohorts. Concerning survival, PD patients with an early onset (below 50 years) had an increased survival rate (p < 0.001)., [Conclusions] Our study showed how several genetic and non-genetic risk factors influenced the age at onset and survival in PD., Irene Rosas was supported by a grant from Fundación Jose Luis Castaño-SEQC. Sergio Pérez-Oliveira is supported by Fundación Parkinson Asturias-Obra Social Cajastur. This study was supported by grant PI 15/00878 (Fondos Feder) to VA.
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- 2022
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20. New insights into the genetic etiology of Alzheimer's disease and related dementias
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Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., Yaqub, A., Prokic, I., Chapuis, J., Ahmad, S., Giedraitis, V., Aarsland, D., Garcia-Gonzalez, P., Abdelnour, C., Alarcón-Martín, E., Alcolea, D., Alegret, M., Alvarez, I., Álvarez, V., Armstrong, N. J., Tsolaki, A., Antúnez, C., Appollonio, I., Arcaro, M., Archetti, S., Pastor, A. A., Arosio, B., Athanasiu, L., Bailly, H., Banaj, N., Baquero, M., Barral, S., Beiser, A., Pastor, A. B., Below, J. E., Benchek, P., Benussi, L., Berr, C., Besse, C., Bessi, V., Binetti, G., Bizarro, A., Blesa, R., Boada, M., Boerwinkle, E., Borroni, B., Boschi, S., Bossù, P., Bråthen, G., Bressler, J., Bresner, C., Brodaty, H., Brookes, K. J., Brusco, L. I., Buiza-Rueda, D., Bûrger, K., Burholt, V., Bush, W. S., Calero, M., Cantwell, L. B., Chene, G., Chung, J., Cuccaro, M. L., Carracedo, Á., Cecchetti, R., Cervera-Carles, L., Charbonnier, C., Chen, H. -H., Chillotti, C., Ciccone, S., Claassen, J. A. H. R., Clark, C., Conti, E., Corma-Gómez, A., Costantini, E., Custodero, C., Daian, D., Dalmasso, M. C., Daniele, A., Dardiotis, E., Dartigues, J. -F., de Deyn, P. P., de Paiva Lopes, K., de Witte, L. D., Debette, S., Deckert, J., del Ser, T., Denning, N., Destefano, A., Dichgans, M., Diehl-Schmid, J., Diez-Fairen, M., Rossi, P. D., Djurovic, S., Duron, E., Düzel, E., Dufouil, C., Eiriksdottir, G., Engelborghs, S., Escott-Price, V., Espinosa, A., Ewers, M., Faber, K. M., Fabrizio, T., Nielsen, S. F., Fardo, D. W., Farotti, L., Fenoglio, C., Fernández-Fuertes, M., Ferrari, R., Ferreira, C. B., Ferri, E., Fin, B., Fischer, P., Fladby, T., Fließbach, K., Fongang, B., Fornage, M., Fortea, J., Foroud, T. M., Fostinelli, S., Fox, N. C., Franco-Macías, E., Bullido, M. J., Frank-García, A., Froelich, L., Fulton-Howard, B., Galimberti, D., García-Alberca, J. M., García-González, P., Garcia-Madrona, S., Garcia-Ribas, G., Ghidoni, R., Giegling, I., Giorgio, G., Goate, A. M., Goldhardt, O., Gomez-Fonseca, D., González-Pérez, A., Graff, C., Grande, G., Green, E., Grimmer, T., Grünblatt, E., Grunin, M., Gudnason, V., Guetta-Baranes, T., Haapasalo, A., Hadjigeorgiou, G., Haines, J. L., Hamilton-Nelson, K. L., Hampel, H., Hanon, O., Hardy, J., Hartmann, A. M., Hausner, L., Harwood, J., Heilmann-Heimbach, S., Helisalmi, S., Heneka, M. T., Hernández, I., Herrmann, M. J., Hoffmann, P., Holmes, C., Holstege, H., Vilas, R. H., Hulsman, M., Humphrey, J., Biessels, G. J., Jian, X., Johansson, C., Jun, G. R., Kastumata, Y., Kauwe, J., Kehoe, P. G., Kilander, L., Ståhlbom, A. K., Kivipelto, M., Koivisto, A., Kornhuber, J., Kosmidis, M. H., Kukull, W. A., Kuksa, P. P., Kunkle, B. W., Kuzma, A. B., Lage, C., Laukka, E. J., Launer, L., Lauria, A., Lee, C. -Y., Lehtisalo, J., Lerch, O., Lleó, A., Longstreth, W., Lopez, O., de Munain, A. L., Love, S., Löwemark, M., Luckcuck, L., Lunetta, K. L., Ma, Y., Macías, J., Macleod, C. A., Maier, W., Mangialasche, F., Spallazzi, M., Marquié, M., Marshall, R., Martin, E. R., Montes, A. M., Rodríguez, C. M., Masullo, C., Mayeux, R., Mead, S., Mecocci, P., Medina, M., Meggy, A., Mehrabian, S., Mendoza, S., Menéndez-González, M., Mir, P., Moebus, S., Mol, M., Molina-Porcel, L., Montrreal, L., Morelli, L., Moreno, F., Morgan, K., Mosley, T., Nöthen, M. M., Muchnik, C., Mukherjee, S., Nacmias, B., Ngandu, T., Nicolas, G., Nordestgaard, B. G., Olaso, R., Orellana, A., Orsini, M., Ortega, G., Padovani, A., Paolo, C., Papenberg, G., Parnetti, L., Pasquier, F., Pastor, P., Peloso, G., Pérez-Cordón, A., Pérez-Tur, J., Pericard, P., Peters, O., Pijnenburg, Y. A. L., Pineda, J. A., Piñol-Ripoll, G., Pisanu, C., Polak, T., Popp, J., Posthuma, D., Priller, J., Puerta, R., Quenez, O., Quintela, I., Thomassen, J. Q., Rábano, A., Rainero, I., Rajabli, F., Ramakers, I., Real, L. M., Reinders, M. J. T., Reitz, C., Reyes-Dumeyer, D., Ridge, P., Riedel-Heller, S., Riederer, P., Roberto, N., Rodriguez-Rodriguez, E., Rongve, A., Allende, I. R., Rosende-Roca, M., Royo, J. L., Rubino, E., Rujescu, D., Sáez, M. E., Sakka, P., Saltvedt, I., Sanabria, Á., Sánchez-Arjona, M. B., Sanchez-Garcia, F., Juan, P. S., Sánchez-Valle, R., Sando, S. B., Sarnowski, C., Satizabal, C. L., Scamosci, M., Scarmeas, N., Scarpini, E., Scheltens, P., Scherbaum, N., Scherer, M., Schmid, M., Schneider, A., Schott, J. M., Selbæk, G., Seripa, D., Serrano, M., Sha, J., Shadrin, A. A., Skrobot, O., Slifer, S., Snijders, G. J. L., Soininen, H., Solfrizzi, V., Solomon, A., Song, Y. E., Sorbi, S., Sotolongo-Grau, O., Spalletta, G., Spottke, A., Squassina, A., Stordal, E., Tartan, J. P., Tárraga, L., Tesí, N., Thalamuthu, A., Thomas, T., Tosto, G., Traykov, L., Tremolizzo, L., Tybjærg-Hansen, A., Uitterlinden, A., Ullgren, A., Ulstein, I., Valero, S., Valladares, O., Broeckhoven, C. V., Vance, J., Vardarajan, B. N., van der Lugt, A., Dongen, J. V., van Rooij, J., van Swieten, J., Vandenberghe, R., Verhey, F., Vidal, J. -S., Vogelgsang, J., Vyhnalek, M., Wagner, M., Wallon, D., Wang, L. -S., Wang, R., Weinhold, L., Wiltfang, J., Windle, G., Woods, B., Yannakoulia, M., Zare, H., Zhao, Y., Zhang, X., Zhu, C., Zulaica, M., Laczo, J., Matoska, V., Serpente, M., Assogna, F., Piras, F., Ciullo, V., Shofany, J., Ferrarese, C., Andreoni, S., Sala, G., Zoia, C. P., Zompo, M. D., Benussi, A., Bastiani, P., Takalo, M., Natunen, T., Laatikainen, T., Tuomilehto, J., Antikainen, R., Strandberg, T., Lindström, J., Peltonen, M., Abraham, R., Al-Chalabi, A., Bass, N. J., Brayne, C., Brown, K. S., Collinge, J., Craig, D., Deloukas, P., Fox, N., Gerrish, A., Gill, M., Gwilliam, R., Harold, D., Hollingworth, P., Johnston, J. A., Jones, L., Lawlor, B., Livingston, G., Lovestone, S., Lupton, M., Lynch, A., Mann, D., Mcguinness, B., Mcquillin, A., O’Donovan, M. C., Owen, M. J., Passmore, P., Powell, J. F., Proitsi, P., Rossor, M., Shaw, C. E., Smith, A. D., Gurling, H., Todd, S., Mummery, C., Ryan, N., Lacidogna, G., Adarmes-Gómez, A., Mauleón, A., Pancho, A., Gailhajenet, A., Lafuente, A., Macias-García, D., Martín, E., Pelejà, E., Carrillo, F., Merlín, I. S., Garrote-Espina, L., Vargas, L., Carrion-Claro, M., Marín, M., Labrador, M., Buendia, M., Alonso, M. 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Peters, O, Pijnenburg, Y, Pineda, J, Piñol-Ripoll, G, Pisanu, C, Polak, T, Popp, J, Posthuma, D, Priller, J, Puerta, R, Quenez, O, Quintela, I, Thomassen, J, Rábano, A, Rainero, I, Rajabli, F, Ramakers, I, Real, L, Reinders, M, Reitz, C, Reyes-Dumeyer, D, Ridge, P, Riedel-Heller, S, Riederer, P, Roberto, N, Rodriguez-Rodriguez, E, Rongve, A, Allende, I, Rosende-Roca, M, Royo, J, Rubino, E, Rujescu, D, Sáez, M, Sakka, P, Saltvedt, I, Sanabria, Á, Sánchez-Arjona, M, Sanchez-Garcia, F, Juan, P, Sánchez-Valle, R, Sando, S, Sarnowski, C, Satizabal, C, Scamosci, M, Scarmeas, N, Scarpini, E, Scheltens, P, Scherbaum, N, Scherer, M, Schmid, M, Schneider, A, Schott, J, Selbæk, G, Seripa, D, Serrano, M, Sha, J, Shadrin, A, Skrobot, O, Slifer, S, Snijders, G, Soininen, H, Solfrizzi, V, Solomon, A, Song, Y, Sorbi, S, Sotolongo-Grau, O, Spalletta, G, Spottke, A, Squassina, A, Stordal, E, Tartan, J, Tárraga, L, Tesí, N, Thalamuthu, A, Thomas, T, Tosto, G, Traykov, L, Tremolizzo, L, Tybjærg-Hansen, A, Uitterlinden, A, Ullgren, A, Ulstein, I, Valero, S, Valladares, O, Broeckhoven, C, Vance, J, Vardarajan, B, van der Lugt, A, Dongen, J, van Rooij, J, van Swieten, J, Vandenberghe, R, Verhey, F, Vidal, J, Vogelgsang, J, Vyhnalek, M, Wagner, M, Wallon, D, Wang, L, Wang, R, Weinhold, L, Wiltfang, J, Windle, G, Woods, B, Yannakoulia, M, Zare, H, Zhao, Y, Zhang, X, Zhu, C, Zulaica, M, Andreoni, S, Ferrarese, C, Sala, G, Zoia, C, Farrer, L, Psaty, B, Ghanbari, M, Raj, T, Sachdev, P, Mather, K, Jessen, F, Ikram, M, de Mendonça, A, Hort, J, Tsolaki, M, Pericak-Vance, M, Amouyel, P, Williams, J, Frikke-Schmidt, R, Clarimon, J, Deleuze, J, Rossi, G, Seshadri, S, Andreassen, O, Ingelsson, M, Hiltunen, M, Sleegers, K, Schellenberg, G, van Duijn, C, Sims, R, van der Flier, W, Ruiz, A, Ramirez, A, Lambert, J, VU University medical center, Amsterdam Neuroscience - Neurodegeneration, Neurology, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Compulsivity, 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[0000-0001-5231-1714], Fabrizio, Tagliavini [0000-0003-1039-7315], Fladby, Tormod [0000-0002-9984-9797], Fornage, Myriam [0000-0003-0677-8158], Fox, Nick C [0000-0002-6660-657X], Bullido, María J [0000-0002-6477-1117], Froelich, Lutz [0000-0003-1494-0813], Galimberti, Daniela [0000-0002-9284-5953], García-Alberca, Jose Maria [0000-0003-2951-6644], Goate, Alison M [0000-0002-0576-2472], González-Pérez, Antonio [0000-0001-9771-5982], Green, Emma [0000-0002-8687-5590], Grünblatt, Edna [0000-0001-8505-7265], Gudnason, Vilmundur [0000-0001-5696-0084], Haapasalo, Annakaisa [0000-0003-0959-2957], Harwood, Janet [0000-0002-3225-0069], Heilmann-Heimbach, Stefanie [0000-0003-1057-465X], Herrmann, Martin J [0000-0001-9970-2122], Holstege, Henne [0000-0002-7688-3087], Biessels, Geert Jan [0000-0001-6862-2496], Jian, Xueqiu [0000-0002-0313-6494], Johansson, Charlotte [0000-0002-5351-1950], Jun, Gyungah R [0000-0002-3230-8697], Kastumata, Yuriko [0000-0002-0188-8094], Kehoe, Patrick G [0000-0002-7542-1139], Kornhuber, Johannes [0000-0002-8096-3987], Kosmidis, Mary H [0000-0001-8790-1220], Lage, Carmen [0000-0003-1703-121X], Launer, Lenore [0000-0002-3238-7612], Lee, Chien-Yueh [0000-0002-4304-974X], Lleó, Alberto [0000-0002-2568-5478], Lopez, Oscar [0000-0002-8546-8256], de Munain, Adolfo Lopez [0000-0002-9509-4032], Lunetta, Kathryn L [0000-0002-9268-810X], Ma, Yiyi [0000-0002-3609-8877], MacLeod, Catherine A [0000-0002-9314-7380], Marquié, Marta [0000-0002-0660-0950], Montes, Angel Martín [0000-0002-1694-786X], Mead, Simon [0000-0002-4326-1468], Medina, Miguel [0000-0002-7016-5340], Menéndez-González, Manuel [0000-0002-5218-0774], Mol, Merel [0000-0003-2533-2530], Morgan, Kevin [0000-0002-8217-2396], Nöthen, Markus M [0000-0002-8770-2464], Muchnik, Carolina [0000-0002-1542-3706], Nacmias, Benedetta [0000-0001-9338-9040], Nicolas, Gael [0000-0001-9391-7800], Nordestgaard, Børge G [0000-0002-1954-7220], Pasquier, Florence [0000-0001-9880-9788], Pastor, Pau [0000-0002-7493-8777], Peloso, Gina [0000-0002-5355-8636], Pérez-Cordón, Alba [0000-0002-6028-0791], Pérez-Tur, Jordi [0000-0002-9111-1712], Pericard, Pierre [0000-0001-8167-6448], Pineda, Juan A [0000-0002-3751-0296], Pisanu, Claudia [0000-0002-9151-4319], Posthuma, Danielle [0000-0001-7582-2365], Puerta, Raquel [0000-0002-1191-5893], Quenez, Olivier [0000-0002-8273-8505], Thomassen, Jesper Qvist [0000-0003-3484-9531], Real, Luis M [0000-0003-4932-7429], Reinders, Marcel JT [0000-0002-1148-1562], Reitz, Christiane [0000-0001-8757-7889], Riedel-Heller, Steffi [0000-0003-4321-6090], Rodriguez-Rodriguez, Eloy [0000-0001-7742-677X], Rongve, Arvid [0000-0002-0476-4134], Sáez, María Eugenia [0000-0001-9299-2534], Saltvedt, Ingvild [0000-0002-7897-9808], Juan, Pascual Sánchez [0000-0002-6081-8037], Sarnowski, Chloé [0000-0002-6090-7099], Satizabal, Claudia L [0000-0002-1115-4430], Schott, Jonathan M [0000-0003-2059-024X], Selbæk, Geir [0000-0001-6511-8219], Shadrin, Alexey A [0000-0002-7467-250X], Soininen, Hilkka [0000-0002-2785-9937], Solfrizzi, Vincenzo [0000-0002-8524-0315], Song, Yeunjoo [0000-0002-7452-3731], Sotolongo-Grau, Oscar [0000-0002-9679-0670], Spalletta, Gianfranco [0000-0002-7432-4249], Squassina, Alessio [0000-0001-7415-7607], Stordal, Eystein [0000-0002-2443-7923], Tosto, Giuseppe [0000-0001-7075-8245], Uitterlinden, Andre [0000-0002-7276-3387], Valladares, Otto [0000-0001-8055-2187], Broeckhoven, Christine Van [0000-0003-0183-7665], Vidal, Jean-Sébastien [0000-0001-6770-0720], Vogelgsang, Jonathan [0000-0001-9326-8193], Wagner, Michael [0000-0003-2589-6440], Wallon, David [0000-0002-2634-7198], Wiltfang, Jens [0000-0003-1492-5330], Woods, Bob [0000-0002-6781-651X], Yannakoulia, Mary [0000-0003-2171-7337], Zare, Habil [0000-0001-5902-6238], Zhang, Xiaoling [0000-0001-8237-1857], Farrer, Lindsay A [0000-0001-5533-4225], Psaty, Bruce M [0000-0002-7278-2190], Ghanbari, Mohsen [0000-0002-9476-7143], Raj, Towfique [0000-0002-9355-5704], Sachdev, Perminder [0000-0002-9595-3220], Mather, Karen [0000-0003-4143-8941], Ikram, M Arfan [0000-0003-0372-8585], Tsolaki, Magda [0000-0002-2072-8010], Pericak-Vance, Margaret A [0000-0001-7283-8804], Amouyel, Philippe [0000-0001-9088-234X], Williams, Julie [0000-0002-4069-0259], Frikke-Schmidt, Ruth [0000-0003-4084-5027], Seshadri, Sudha [0000-0001-6135-2622], Andreassen, Ole A [0000-0002-4461-3568], Sleegers, Kristel [0000-0002-0283-2332], van Duijn, Cornelia M [0000-0002-2374-9204], Sims, Rebecca [0000-0002-3885-1199], van der Flier, Wiesje M [0000-0001-8766-6224], Ramirez, Alfredo [0000-0003-4991-763X], Lambert, Jean-Charles [0000-0003-0829-7817], Apollo - University of Cambridge Repository, Complex Trait Genetics, Clinical sciences, Neuroprotection & Neuromodulation, Pathologic Biochemistry and Physiology, Clinical Biology, Epidemiology, Internal Medicine, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Med Staf Spec Psychiatrie (9), UAM. Departamento de Biología Molecular, University of Helsinki, Department of Neurosciences, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, HUS Neurocenter, Neurologian yksikkö, Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Institut Pasteur, Institut National de la Santé et de la Recherche Médicale (France), European Commission, LabEx DISTALZ, Pérez-Tur, Jordi, University Children’s Hospital Basel (Suiza), INSERM (Francia), Lille Métropole Communauté Urbaine, Government of France (Francia), EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC, CHARGE, Holmans, Peter A. [0000-0003-0870-9412], van der Lee, Sven J. [0000-0003-1606-8643], Costa, Marcos R. [0000-0002-4928-2163], Bis, Joshua C. [0000-0002-3409-1110], Brookes, Keeley J. [0000-0003-2427-2513], Bush, William S. [0000-0002-9729-6519], de Witte, Lot D. [0000-0002-7235-9958], del Ser, Teodoro [0000-0001-9806-7083], Fox, Nick C. [0000-0002-6660-657X], Bullido, María J. [0000-0002-6477-1117], Goate, Alison M. [0000-0002-0576-2472], Herrmann, Martin J. [0000-0001-9970-2122], Jun, Gyungah R. [0000-0002-3230-8697], Kehoe, Patrick G. [0000-0002-7542-1139], Kosmidis, Mary H. [0000-0001-8790-1220], Lunetta, Kathryn L. [0000-0002-9268-810X], MacLeod, Catherine A. [0000-0002-9314-7380], Nöthen, Markus M. [0000-0002-8770-2464], Nordestgaard, Børge G. [0000-0002-1954-7220], Pineda, Juan A. [0000-0002-3751-0296], Real, Luis M. [0000-0003-4932-7429], Reinders, Marcel J. T. [0000-0002-1148-1562], Satizabal, Claudia L. [0000-0002-1115-4430], Schott, Jonathan M. [0000-0003-2059-024X], Shadrin, Alexey A. [0000-0002-7467-250X], Farrer, Lindsay A. [0000-0001-5533-4225], Psaty, Bruce M. [0000-0002-7278-2190], Ikram, M. Arfan [0000-0003-0372-8585], Pericak-Vance, Margaret A. [0000-0001-7283-8804], Andreassen, Ole A. [0000-0002-4461-3568], van Duijn, Cornelia M. [0000-0002-2374-9204], van der Flier, Wiesje M. [0000-0001-8766-6224], and Molecular Neuroscience and Ageing Research (MOLAR)
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tau Proteins/genetics ,Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] ,Neurologi ,MED/03 - GENETICA MEDICA ,45/43 ,Medizin ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,genetics [Alzheimer Disease] ,Genome-Wide Association Study ,Humans ,tau Proteins ,Alzheimer Disease ,Cognitive Dysfunction ,VARIANTS ,pathology [Alzheimer Disease] ,Tau Proteins ,Settore BIO/13 - Biologia Applicata ,Cognitive Dysfunction/psychology ,692/699/375/365/1283 ,IMPUTATION ,article ,1184 Genetics, developmental biology, physiology ,Biología y Biomedicina / Biología ,AMYLOID-BETA ,Settore MED/26 - NEUROLOGIA ,Neurology ,psychology [Cognitive Dysfunction] ,Medical Genetics ,Human ,Neuroscience(all) ,631/208/205/2138 ,All institutes and research themes of the Radboud University Medical Center ,SDG 3 - Good Health and Well-being ,ddc:570 ,Genetics ,Genetic Predisposition to Disease ,GENOME-WIDE ASSOCIATION ,METAANALYSIS ,Medicinsk genetik ,MED/26 - NEUROLOGIA ,Alzheimer Disease/genetics ,neurology ,tau Protein ,NECROSIS-FACTOR-ALPHA ,RISK LOCI ,genetics [tau Proteins] ,PREDICTION MODELS ,Human medicine ,GENERATION ,RESPONSES - Abstract
25 páginas, 6 figuras, 2 tablas, Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele., This work was funded by a grant (EADB) from the EU Joint Programme – Neurodegenerative Disease Research. INSERM UMR1167 is also funded by the INSERM, Institut Pasteur de Lille, Lille Métropole Communauté Urbaine and French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD). Full consortium acknowledgements and funding are in the Supplementary Not
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- 2022
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21. Congruences for critical values of higher derivatives of twisted Hasse–Weil L-functions, III
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Daniel Macias Castillo and Werner Bley
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Abelian variety ,Pure mathematics ,Conjecture ,Mathematics - Number Theory ,Group (mathematics) ,Mathematics::Number Theory ,General Mathematics ,Prime number ,Congruence relation ,Algebraic number field ,Galois module ,FOS: Mathematics ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Equivariant map ,Number Theory (math.NT) ,Mathematics - Abstract
Let $A$ be an abelian variety defined over a number field $k$, let $p$ be an odd prime number and let $F/k$ be a cyclic extension of $p$-power degree. Under not-too-stringent hypotheses we give an interpretation of the $p$-component of the relevant case of the equivariant Tamagawa number conjecture in terms of integral congruence relations involving the evaluation on appropriate points of $A$ of the ${\rm Gal}(F/k)$-valued height pairing of Mazur and Tate. We then discuss the numerical computation of this pairing, and in particular obtain the first numerical verifications of this conjecture in situations in which the $p$-completion of the Mordell-Weil group of $A$ over $F$ is not a projective Galois module., Comment: Final version, 26 pages. To appear in Math. Proc. Camb. Phil. Soc
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- 2021
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22. Heat Transfer in Cassava Starch Biopolymers: Effect of the Addition of Borax
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Nayda Patricia Arias Duque, Juan Jose Alvarado-Gil, Joan Alexis Castro-Betancur, Juan Daniel Macias, Oscar Hernán Giraldo Osorio, F. Cervantes-Alvarez, Reynell Junior Pérez-Blanco, Geonel Rodríguez-Gattorno, and Adriana Paola Franco-Bacca
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chemistry.chemical_classification ,cassava starch biopolymer ,Materials science ,Polymers and Plastics ,Starch ,Borax ,Organic chemistry ,General Chemistry ,Polymer ,engineering.material ,Article ,Polymer engineering ,chemistry.chemical_compound ,QD241-441 ,Thermal conductivity ,chemistry ,Chemical engineering ,borax ,Volume fraction ,Heat transfer ,engineering ,thermal conductivity ,Biopolymer ,cross-linking - Abstract
In recent years, polymer engineering, at the molecular level, has proven to be an effective strategy to modulate thermal conductivity. Polymers have great applicability in the food packaging industry, in which transparency, lightness, flexibility, and biodegradability are highly desirable characteristics. In this work, a possible manner to adjust the thermal conductivity in cassava starch biopolymer films is presented. Our approach is based on modifying the starch molecular structure through the addition of borax, which has been previously used as an intermolecular bond reinforcer. We found that the thermal conductivity increases linearly with borax content. This effect is related to the crosslinking effect that allows the principal biopolymer chains to be brought closer together, generating an improved interconnected network favoring heat transfer. The highest value of the thermal conductivity is reached at a volume fraction of 1.40% of borax added. Our analyses indicate that the heat transport improves as borax concentration increases, while for borax volume fractions above 1.40%, heat carriers scattering phenomena induce a decrement in thermal conductivity. Additionally, to obtain a deeper understanding of our results, structural, optical, and mechanical characterizations were also performed.
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- 2021
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23. Ueno’s brown frogRana uenoiindiscriminately ceases calling in the presence of daytime birds
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Kyungmin Kim, Amaël Borzée, Yikweon Jang, and Daniel Macias
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0106 biological sciences ,Ecology ,fungi ,05 social sciences ,food and beverages ,Biology ,010603 evolutionary biology ,01 natural sciences ,Predation ,Rana uenoi ,0501 psychology and cognitive sciences ,Animal Science and Zoology ,050102 behavioral science & comparative psychology ,Ecology, Evolution, Behavior and Systematics - Abstract
Animals need to recognise predators to assess threats and adjust their behaviour accordingly. Acoustic cues produced to attract mates may also be intercepted by predators, and signallers can use bo...
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- 2020
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24. Congruences for critical values of higher derivatives of twisted Hasse–Weil $L$-functions, II
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Daniel Macias Castillo
- Subjects
Pure mathematics ,Algebra and Number Theory ,Congruence relation ,Mathematics - Published
- 2020
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25. On Refined Conjectures of Birch and Swinnerton-Dyer Type for Hasse–Weil–Artin $L$-Series
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David Burns, Daniel Macias Castillo, David Burns, and Daniel Macias Castillo
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- Birch-Swinnerton-Dyer conjecture, Weil conjectures, Curves, Elliptic, Abelian varieties, Algebraic number theory, Number theory--Arithmetic algebraic geometry (Di, Number theory--Algebraic number theory: global f
- Abstract
View the abstract.
- Published
- 2024
26. Experimental Evaluation and Modeling of Air Heating in a Ceramic Foam Volumetric Absorber by Effective Parameters
- Author
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Carlos Ernesto Arreola-Ramos, Armando Rojas-Morin, Camilo A. Arancibia-Bulnes, Aldo Javier Guadarrama-Mendoza, Omar Álvarez-Brito, Juan Daniel Macias, Patricio J. Valadés-Pelayo, Manuel A. Ramírez-Cabrera, and H.I. Villafán-Vidales
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Technology ,Control and Optimization ,Materials science ,020209 energy ,Airflow ,Energy Engineering and Power Technology ,02 engineering and technology ,Heat transfer coefficient ,Thermal conductivity ,0202 electrical engineering, electronic engineering, information engineering ,heat transfer model ,Electrical and Electronic Engineering ,Composite material ,Porosity ,Thermal analysis ,Engineering (miscellaneous) ,Renewable Energy, Sustainability and the Environment ,volumetric effect ,020208 electrical & electronic engineering ,volumetric heat transfer coefficient ,Temperature gradient ,PSZ porous absorber ,Heat transfer ,Porous medium ,Energy (miscellaneous) - Abstract
Reticulate porous ceramic reactors use foam-type absorbers in their operation which must fulfill two essential functions: favoring the volumetric effect and increasing the mass and heat transfer by acting as a support for the reactive materials. Heating these absorbers with highly inhomogeneous concentrate irradiation induces high thermal gradients that affect their thermal performance. Owing to the critical function of these component in the reactor, it is necessary to define a selection criterion for the foam-type absorbers. In this work, we performed an experimental and numerical thermal analysis of three partially stabilized zirconia (PSZ) foam-type absorbers with pore density of 10, 20, and 30 PPI (pores per inch) used as a volumetric absorber. A numerical model and an analytical approximation were developed to reproduce experimental results, and calculate the thermal conductivity, as well as volumetric heat transfer coefficient. The results show that an increase in pore density leads to an increase in the temperature difference between the irradiated face and the rear face of the absorber, this occurs because when pore density increases the concentrated energy no longer penetrates in the deepest space of the absorber and energy is absorbed in areas close to the surface, therefore, temperature gradients are created within the porous medium. The opposite effect occurs when the airflow rate increases, the temperature gradient between the irradiated face and the rear face is reduced. This behavior is more noticeable at low pore densities, but at high pore densities, the effect is less relevant because the internal structure of porous absorbers with high pore density is more complex, which offers obstructions or physical barriers to airflow and thermal barriers to heat transfer. When the steady state is reached, the temperature difference between the two faces of the absorber remains constant if the concentrate irradiation changes slightly, even changing the airflow rate. The results obtained in this work allow us to establish a selection criterion for porous absorbers that operate within solar reactors, this criterion is based on knowledge of the physical properties of the porous absorber, the environment, the working conditions, and the results expected.
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- 2021
27. Validation of a fear checklist in Mexican population/Validacion de una lista de miedos en poblacion Mexicana/Validacao de uma lista de medos em populacao Mexicana
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Hernandez-Pozo, Maria Del Rocio, Calleja, Nazira, Velasco, Alejandra Sanchez, Alvarez, Osmaldo Coronado, Martinez, Daniel Macias, and Resendiz, Sandra Cerezo
- Published
- 2009
28. On special elements for $\mathbb{G}_m$
- Author
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Burns, David, Castillo, Daniel Macias, and Seo, Soogil
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Mathematics - Number Theory ,FOS: Mathematics ,Number Theory (math.NT) - Abstract
We construct, unconditionally and in a very general setting, a canonical family of elements in the reduced exterior power lattices of unit groups of global fields. We show these elements generalise cyclotomic elements and we determine their detailed arithmetic properties. We are thereby led to the formulation of refined versions of Stark's conjectures on the values at zero of Artin $L$-series and, in several important cases, we provide concrete evidence in support of these refinements., Comment: 72 pages
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- 2021
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29. A geroscience approach for Parkinson's disease: Conceptual framework and design of PROPAG-AGEING project
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Chiara Pirazzini, Tiago Azevedo, Luca Baldelli, Anna Bartoletti-Stella, Giovanna Calandra-Buonaura, Alessandra Dal Molin, Giovanna Maria Dimitri, Ivan Doykov, Pilar Gómez-Garre, Sara Hägg, Jenny Hällqvist, Claire Halsband, Wendy Heywood, Silvia Jesús, Juulia Jylhävä, Katarzyna Malgorzata Kwiatkowska, Miguel A. Labrador-Espinosa, Cristina Licari, Maria Giovanna Maturo, Giacomo Mengozzi, Gaia Meoni, Maddalena Milazzo, Maria Teresa Periñán-Tocino, Francesco Ravaioli, Claudia Sala, Luisa Sambati, Sebastian Schade, Sebastian Schreglmann, Simeon Spasov, Leonardo Tenori, Dylan Williams, Luciano Xumerle, Elisa Zago, Kailash P. Bhatia, Sabina Capellari, Pietro Cortelli, Paolo Garagnani, Henry Houlden, Pietro Liò, Claudio Luchinat, Massimo Delledonne, Kevin Mills, Pablo Mir, Brit Mollenhauer, Christine Nardini, Nancy L. Pedersen, Federica Provini, Stephen Strom, Claudia Trenkwalder, Paola Turano, Maria Giulia Bacalini, Claudio Franceschi, Astrid Adarmes-Gómez, Marta Bonilla-Toribio, Claudia Boninsegna, Marcella Broli, Dolores Buiza-Rueda, Mario Carrión-Claro, Rosalia Cilea, Robert Clayton, Silvia De Luca, Patrizia De Massis, Rocio Escuela-Martin, Giovanni Fabbri, Anna Gabellini, Cristina Giuliani, Pietro Guaraldi, Ismae Huertas, Daniel Macias, Stefania Macrì, Francesca Magrinelli, Juan Francisco Martín Rodríguez, Francesco Mignani, Stefania Alessandra Nassetti, Cesa Lorella Maria Scaglione, Cristina Tejera-Parrado, Franco Valzania, Rosario Vigo Ortega, Pirazzini C., Azevedo T., Baldelli L., Bartoletti-Stella A., Calandra Buonaura G., Dal Molin A., Dimitri G.M., Doykov I., Gomez-Garre P., Hagg S., Hallqvist J., Halsband C., Heywood W., Jesus S., Jylhava J., Kwiatkowska K.M., Labrador-Espinosa M.A., Licari C., Maturo M.G., Mengozzi G., Meoni G., Milazzo M., Perinan-Tocino M.T., Ravaioli F., Sala C., Sambati L., Schade S., Schreglmann S., Spasov S., Tenori L., Williams D., Xumerle L., Zago E., Bhatia K.P., Capellari S., Cortelli P., Garagnani P., Houlden H., Lio P., Luchinat C., Delledonne M., Mills K., Mir P., Mollenhauer B., Nardini C., Pedersen N.L., Provini F., Strom S., Trenkwalder C., Turano P., Bacalini M.G., Franceschi C., Adarmes-Gomez A., Bonilla-Toribio M., Boninsegna C., Broli M., Buiza-Rueda D., Carrion-Claro M., Cilea R., Clayton R., Molin A.D., De Luca S., De Massis P., Escuela-Martin R., Fabbri G., Gabellini A., Giuliani C., Guaraldi P., Huertas I., Macias D., Macri S., Magrinelli F., Rodriguez J.F.M., Mignani F., Nassetti S.A., Scaglione C.L.M., Tejera-Parrado C., Valzania F., and Ortega R.V.
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0301 basic medicine ,Gerontology ,Male ,Aging ,Parkinson's disease ,Biomedical Research ,Inflammaging ,Neurodegeneration ,Omics ,Disease ,Motor Activity ,03 medical and health sciences ,0302 clinical medicine ,Omic ,medicine ,Humans ,Metabolomics ,Risk factor ,Aged ,Aged, 80 and over ,Neurons ,Geroscience ,business.industry ,Age Factors ,Brain ,Parkinson Disease ,Genomics ,medicine.disease ,3. Good health ,Europe ,030104 developmental biology ,Conceptual framework ,Ageing ,Geriatrics ,Research Design ,Case-Control Studies ,Nerve Degeneration ,Twin Studies as Topic ,Female ,Healthy ageing ,Inflammation Mediators ,business ,030217 neurology & neurosurgery ,Motor disability ,Developmental Biology ,Signal Transduction - Abstract
Advanced age is the major risk factor for idiopathic Parkinson's disease (PD), but to date the biological relationship between PD and ageing remains elusive. Here we describe the rationale and the design of the H2020 funded project "PROPAG-AGEING", whose aim is to characterize the contribution of the ageing process to PD development. We summarize current evidences that support the existence of a continuum between ageing and PD and justify the use of a Geroscience approach to study PD. We focus in particular on the role of inflammaging, the chronic, low-grade inflammation characteristic of elderly physiology, which can propagate and transmit both locally and systemically. We then describe PROPAG-AGEING design, which is based on the multi-omic characterization of peripheral samples from clinically characterized drug-naive and advanced PD, PD discordant twins, healthy controls and "super-controls", i.e. centenarians, who never showed clinical signs of motor disability, and their offspring. Omic results are then validated in a large number of samples, including in vitro models of dopaminergic neurons and healthy siblings of PD patients, who are at higher risk of developing PD, with the final aim of identifying the molecular perturbations that can deviate the trajectories of healthy ageing towards PD development.
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- 2020
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30. A cien años de Annual : La Guerra de Marruecos
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Juan Carlos Pereira Castañares, José Carlos Aránguez Aránguez, Francisco Escribano Bernal, Fernando Puell de la Villa, María Rosa de Madariaga Álvarez-Prida, Julio Albi de la Cuesta, Roberto Muñoz Bolaños, Ramón Díez Rioja, Daniel Macías Fernández, Mercedes Cabrera Calvo-Sotelo, Alfonso Iglesias Amorín, José Vicente Herrero Pérez, Juan Miguel Sánchez Vigil, Juan Carlos Pereira Castañares, José Carlos Aránguez Aránguez, Francisco Escribano Bernal, Fernando Puell de la Villa, María Rosa de Madariaga Álvarez-Prida, Julio Albi de la Cuesta, Roberto Muñoz Bolaños, Ramón Díez Rioja, Daniel Macías Fernández, Mercedes Cabrera Calvo-Sotelo, Alfonso Iglesias Amorín, José Vicente Herrero Pérez, and Juan Miguel Sánchez Vigil
- Subjects
- Anual, Battle of, Annoual, Morocco, 1921, Rif Revolt, 1921-1926
- Abstract
Las campañas de Marruecos, que se extendieron durante casi dos décadas, entre 1909 y 1927, marcaron indeleblemente la historia de España durante el siglo XX. Miles de soldados españoles hubieron de combatir en durísimas condiciones en las abruptas regiones del norte del Magreb, el Rif, en un rosario de intermitentes operaciones y choques que incluyeron horribles desastres como el del barranco del Lobo o el de Annual, del que se cumplen ahora cien años. Las consecuencias de esta debacle fueron mucho más allá de las terribles pérdidas humanas, ya puso la semilla para el golpe de Estado del general Primo de Rivera de 1923, siendo las campañas de Marruecos la incubadora de los militares africanistas, cuyo papel fue clave en la sublevación de 1936 que dio origen a la guerra civil. El presente volumen aborda este crucial episodio de la mano de los principales especialistas en la materia, para ofrecer un fresco coral y completo, enriquecido con un nutrido aparato cartográfico y fotográfico, que incluye imágenes inéditas. Como guinda, un epílogo con las reflexiones de Lorenzo Silva sobre unos acontecimientos cuya sombra sigue proyectándose sobre la España actual.
- Published
- 2021
31. Uncertainty propagation in observational references to climate model scales
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Daniel Macias-Gómez, Stefan Siegert, François Massonnet, Chloé Prodhomme, Omar Bellprat, Virginie Guemas, and Francisco J. Doblas-Reyes
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Propagation of uncertainty ,010504 meteorology & atmospheric sciences ,Meteorology ,Computer science ,0208 environmental biotechnology ,Soil Science ,Climate change ,Forecast skill ,Geology ,02 engineering and technology ,01 natural sciences ,020801 environmental engineering ,Climatology ,Observational study ,Climate model ,Satellite ,Sensitivity analysis ,Computers in Earth Sciences ,Physics::Atmospheric and Oceanic Physics ,Uncertainty analysis ,0105 earth and related environmental sciences ,Remote sensing - Abstract
Climate model simulations and observational references of the Earth's climate are the two primary sources of information used for climate related decision-making. While uncertainties in climate models and observational references have been assessed thoroughly, it has remained difficult to integrate these, partly because of the lack of formal concepts on how to consider observational uncertainties in model-observation comparison. One of the difficulties dealing with observational uncertainty is its propagation to the space–time scales represented by the models. This is a challenge due to the correlation of observational errors in space and time. Here we present an approximation which allows to derive propagation factors to different model scales and apply these to uncertainty estimates provided by the Climate Change Initiative (CCI) sea-surface temperature (SST) data set. The propagated uncertainty in SST observations is found to systematically lower seasonal forecast skill and to increase the uncertainty in verification of seasonal forecasts, an aspect that remains currently overlooked. Uncertainty in forecast quality assessment is dominated by the shortness of the satellite record. Expanding the record length of these data sets might hence reduce the verification uncertainties more than the efforts to reduce the observational uncertainties.
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- 2017
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32. An update on the conservation status and ecology of Korean terrestrial squamates
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Amaël Borzée, Yucheol Shin, and Daniel Macias
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0106 biological sciences ,Resource (biology) ,Near-threatened species ,Ecology ,biology ,010604 marine biology & hydrobiology ,Poaching ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,Habitat destruction ,Geography ,Elaphe schrenckii ,Threatened species ,Conservation status ,IUCN Red List ,Nature and Landscape Conservation - Abstract
The ecology of most squamates from the Republic of Korea is poorly understood: information on tolerances to environmental variables, movement patterns, home range sizes, and other aspects of their natural history and ecological requirements are lacking. In turn, this lack of knowledge presents an obstacle to effective conservation management. Currently and at the national level, two of Korea’s eleven terrestrial snake species are listed as threatened or near threatened: Elaphe schrenckii and Sibynophis chinensis, and one out of the six lizard species (Eremias argus) is listed as threatened. However, various threats including habitat loss, climate change and poaching may have already but unknowingly elevated other Korean reptiles to threatened statuses. To help resource managers in developing conservation programs, we provide a summary of the literature on threats to Korean squamates, a national recommended threat status, and species accounts focused on Korean populations. We recommend listing Hebius vibakari, E. argus, Scincella huanrenensis and Gekko japonicus under a higher threat level than the one provided by either the Korean National Institute of Biological Resources or the IUCN Red List. Our results highlight that conservation plans are urgently needed for Korean squamates, mostly because of habitat destruction, and that additional research has to be conducted on most species as there is a clear need for integrated ecological studies and active monitoring programs.
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- 2021
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33. Thermal Characterization of Carbon Fiber-Reinforced Carbon Composites (C/C)
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Juan Daniel Macias, O. Arés-Muzio, F. Cervantes-Alvarez, R. Li Voti, Juan Jose Alvarado-Gil, Geonel Rodríguez-Gattorno, Camilo A. Arancibia-Bulnes, Jose Ordonez-Miranda, J. Bante-Guerra, Víctor H. Ramos-Sánchez, H.I. Villafán-Vidales, H. Romero-Paredes, Instituto Mexicano del Petróleo (IMP), Departamento de Ingeniería de Procesos e Hidráulica, Universidad Autonoma Metropolitana - Iztapalapa, Institut Pprime (PPRIME), ENSMA-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers, and CINVESTAV IPN Unidad Merida, Dept Appl Phys, Merida 97310, Mexico
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0301 basic medicine ,Materials science ,Solid thermal conductivity ,[PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph] ,02 engineering and technology ,Thermal diffusivity ,Carbon fiber-reinforced carbon ,Anisotropic structures ,03 medical and health sciences ,Thermal conductivity ,[PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph] ,Thermal ,Radiative transfer ,Rosseland extinction coefficient ,Graphite ,[PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph] ,Composite material ,[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,Electrical conductor ,[PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph] ,030102 biochemistry & molecular biology ,C/C composite ,Radiative thermal conductivity ,Solar thermal technology ,Ceramics and Composites ,[SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment ,[SPI.NRJ]Engineering Sciences [physics]/Electric power ,Atmospheric temperature range ,[PHYS.MECA.MSMECA]Physics [physics]/Mechanics [physics]/Materials and structures in mechanics [physics.class-ph] ,021001 nanoscience & nanotechnology ,Radiative conductivity ,Characterization (materials science) ,[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] ,[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism ,[PHYS.MECA.THER]Physics [physics]/Mechanics [physics]/Thermics [physics.class-ph] ,0210 nano-technology - Abstract
International audience; Carbon fiber-reinforced carbon (C/C) composites consist in a carbon matrix holding carbon or graphite fibers together, whose physical properties are determined not only by those of their individual components, but also by the layer buildup and the material preparation and processing. The complex structure of C/C composites along with the fiber orientation provide an effective means for tailoring their mechanical, electrical, and thermal properties. In this work, we use the Laser Flash Technique to measure the thermal diffusivity and thermal conductivity of C/C composites made up of laminates of weaved bundles of carbon fibers, forming a regular and repeated orthogonal pattern, embedded in a graphite matrix. Our experimental data show that: i) the cross-plane thermal conductivity remains practically constant around (5.3 ± 0.4) W*m−1 K−1, within the temperature range from 370 K to 1700 K. ii) The thermal diffusivity and thermal conductivity along the cross-plane direction to the fibers axis is about five times smaller than the corresponding ones in the laminates plane. iii) The measured cross-plane thermal conductivity is well described by a theoretical model that considers both the conductive and radiative thermal contributions of the effective thermal conductivity.
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- 2019
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34. Photothermal and thermography techniques applied in the characterization of the thermophysical properties of solar absorbers: A review
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Hernando Romero Paredes, Heidi Isabel Villafan Vidales, Juan José Alvarado Gil, Juan Daniel Macias, Victor Ramos Sánchez, Camilo Alberto Arancibia Bulnes, Jose Bante Guerra, and Oscar Eduardo Ares Muzio
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Materials science ,Infrared ,business.industry ,Thermography ,Optoelectronics ,Thermal emittance ,Astrophysics::Earth and Planetary Astrophysics ,Photothermal therapy ,business ,Absorption (electromagnetic radiation) ,Solar energy ,Solar power ,Characterization (materials science) - Abstract
The efficient generation of renewable energies from solar radiation implies the precise knowledge of the thermophysical properties of the materials and systems involved in such applications, this knowledge is fundamental, since it allows us to evaluate and optimize the performance of materials and methods. One of the great challenges for the efficient use of solar energy is the study of the phenomena involved in the interaction of radiation with matter, and the conversion of energy absorbed into heat. Photothermal and thermographic techniques are ideal methodologies to study these phenomena, since they are non-contact techniques (NCT) and, therefore, can be applied in a wide range of operating temperatures and environments. In general, photothermal techniques consist in illuminating the surface of the sample with a laser light beam modulated or pulsed, therefore the sample is heated and emits infrared radiation IR (among other types of energy). The variations of the IR energy are related to the thermophysical properties of the specimens photothermal techniques are based on the detection of these variations. Some examples of photothermal methodologies are the photothermal radiometry pulsed (PPTR) and modulated (PTR), the photothermal reflectometry (RM) and the thermal wave resonant cavity (TWRC). Infrared thermography is a powerful method of non-contact measurement, using this technique thermal images or thermograms are obtained, which are a representation of the temperature distribution on the surface of an object or a scene. The thermophysical properties of materials they are obtained through the analysis of amplitude and phase signals, as well as thermograms. Reflectance spectroscopy is a powerful tool for characterizing the optical properties (solar absorbance and thermal emittance) of a great diversity of materials applied in solar technology. The analysis can be done in two wavelength ranges of interest: Ultraviolet/visible/near infrared and medium infrared, where solar spectrum radiation wavelengths and infrared emission range are located respectively. The methodologies mentioned have been applied in the characterization of materials at room temperature, however, many processes involved in the new applications of solar energy occur at high temperature. It has also been shown that thermophysical mechanisms related to the conversion of energy that occur at room temperature are not dominant in high temperature regimes therefore, the measurement of the conversion, absorption, emission and energy exchange processes to high temperature, they involve new technological challenges. In this work, we present a summary about the photothermal, thermographic and reflectance spectroscopy techniques, used in the evaluation of the thermophysical properties of solar absorbers applied in low temperature solar systems, as well as high temperature concentrate solar power (CSP) systems.
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- 2019
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35. On non-abelian higher special elements of $p$-adic representations
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Daniel Macias Castillo and Kwok-Wing Tsoi
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Mathematics - Number Theory ,General Mathematics ,Mathematics::Number Theory ,FOS: Mathematics ,Number Theory (math.NT) - Abstract
We develop a theory of `non-abelian higher special elements' in the non-commutative exterior powers of the Galois cohomology of $p$-adic representations. We explore their relation to the theory of organising matrices and thus to the Galois module structure of Selmer modules. In concrete applications, we relate our general theory to the formulation of refined conjectures of Birch and Swinnerton-Dyer type and to the Galois structure of Tate-Shafarevich and Selmer groups of abelian varieties., Comment: Updated References
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- 2019
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36. Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks : The GR@ACE project
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Jordi Clarimón, G. Monté-Rubio, Miguel A. Santos-Santos, L. Vargas, E. Pelejà, M.T. Martínez, E. Alarcón-Martín, A. Mauleón, P. Martínez-Lage Álvarez, A. Carracedo, N. Aguilera, Goo Amer-Ferrer, M.J. Bullido, Pascual Sánchez-Juan, Olalla Maroñas, J.A. Pineda, Carmen Martínez, Carmen Lage, Antonio González-Pérez, V. Martínez, Angel Carracedo, Susana Ruiz, A. López de Munáin, E. L. Martin, O. Maroñas, Manuel Menéndez-González, Begoña Hernández-Olasagarre, Luis Miguel Real, S. Ruiz, Marta Marquié, Pablo Mir, Montse Alegret, María J. Bullido, Pilar Gómez-Garre, A. Sanabria, Carla Abdelnour, Silvia Jesús, M.M. de Pancorbo, J. Clarimón, Agustín Ruiz, M. Boada, José María García-Alberca, J.M. Cruz-Gamero, Ignacio Alvarez, P. Mir, Adelina Orellana, Alberto Rábano, J.L. Royo, Alberto Lleó, M.J. Casajeros, O. Sotolongo-Grau, R. Sanchez del Valle Díaz, Ana Espinosa, Nuria Aguilera, G. Piñol Ripoll, J. Pérez Tur, S. Manzanares, M. Marquié, Miguel Medina, S. Rodrigo, Teresa Periñán-Tocino, A. Rábano, A. Martín Montes, A. Gailhajenet, Daniel Macias, Ana Mauleón, E. Franco, Miguel Calero, Adela Orellana, P. Cañabate, M. Rosende-Roca, Jose Luis Royo, Gemma Ortega, M. Moreno, Juan A. Pineda, Marina Guitart, Marta Ibarria, A. Benaque, Maria Eugenia Sáez, Manuel Serrano-Ríos, A. Ruiz, Carmen Antúnez, Mariola Moreno, Juan Macías, Pilar Cañabate, L.M. Real, A. Lafuente, Astrid Adarmes-Gómez, Fátima Carrillo, A. Espinosa, T. Marín, S. Preckler, T. del Ser, Eloy Rodríguez-Rodríguez, S. Moreno-Grau, Susana Diego, Gemma Monté-Rubio, L. Montrreal, Rafael Blesa, Mercè Boada, M.P. Vicente, Asunción Lafuente, Emilio Franco, B. Martínez, Laura Montrreal, Itziar de Rojas, I. Hernández, Mario Carrión-Claro, Alba Benaque, I. de Rojas, Emilio Alarcón-Martín, Jesús Avila, S. Garcia Madrona, S. Valero, D. Real de Asúa, L. Vivancos, Ana Frank-García, J.A. Burguera, Liliana Vargas, Labrador Espinosa, Sara López-García, Angela Sanabria, Ana Pancho, A.B. Pastor, Juan Fortea, A. Legaz, Oscar Sotolongo-Grau, Laura Madrid, Sonia Moreno-Grau, J. Marín-Muñoz, M. Calero, Emilio Alarcón, Lluís Tárraga, M. Marín, Miquel Baquero, Sergi Valero, Mar Buendía, José-Luis Molinuevo, M. Mendioroz Iriarte, Alba Pérez-Cordón, C. Abdelnour, V. Álvarez, Pau Pastor, Silvia Gil, J.M. García-Alberca, A. González Pérez, A. Pérez-Cordon, Maitée Rosende-Roca, O. Rodríguez-Gómez, Victoria Alvarez, Isabel Sastre, Inés Quintela, Guillermo García-Ribas, Isabel Hernández, Octavio Rodriguez-Gomez, Arturo Corbatón, G. Ortega, C. Antúnez, P. García González, Monica Diez-Fairen, P. Pastor, P. Sánchez-Juan, L. Tárraga, G. Garcia-Ribas, Montserrat Alegret, S. Hevilla, Maria Jose Bernal, María Eugenia Sáez, M. Medina, I. Quintela, Silvia Preckler, M. Antequera, Dolores Buiza-Rueda, M.A. Santos-Santos, Gerard Piñol-Ripoll, S. Gil, European Commission, Universidad de Cantabria, Fundación La Caixa, Grifols (Spain), Fundació ACE, Instituto de Salud Carlos III, Ministerio de Sanidad (España), Unión Europea, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Regional Government of Andalusia (España), National Institutes of Health (Estados Unidos), United States Department of Defense, NIH - National Institute on Aging (NIA) (Estados Unidos), NIH - National Institute of Biomedical Imaging and Bioengineering (NIBIB) (Estados Unidos), Innovative Medicines Initiative, Unión Europea. Comisión Europea. 6 Programa Marco, Alzheimer's Disease Genetics Consortium, GRIFOLS, European Union, European Regional Development Fund (ERDF/FEDER), Gobierno de Andalucía, National Institutes of Health (United States), Department of Defense USA, National Institute on Aging, National Institute of Biomedical Imaging and Bioengineering, and 6º Programa Marco - Comisión Europea
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0301 basic medicine ,Male ,Epidemiology ,humanos ,vascular pathology ,enfermedad de Alzheimer ,Genome-wide association study ,Disease ,demencia ,0302 clinical medicine ,sitios genéticos ,GWAS ,Cerebrovascular disease ,mediana edad ,anciano ,Health Policy ,gwas ,Alzheimer's disease ,Middle Aged ,rare ,Causality ,3. Good health ,Psychiatry and Mental health ,Biological Pathway ,alzheimer's disease ,Female ,Cerebral amyloid angiopathy ,Malalties cerebrovasculars ,biological pathway ,metaanalysis ,Endophenotypes ,onset ,Vascular Pathology ,Computational biology ,Biology ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Alzheimer Disease ,medicine ,Dementia ,Humans ,Genetic Predisposition to Disease ,Alzheimer’s Disease ,endofenotipos ,gene ,Gene ,cerebral amyloid angiopathy ,cognitive function ,Aged ,Mechanism (biology) ,predisposición genética a la enfermedad ,medicine.disease ,mutations ,immunity ,Cerebral Amyloid Angiopathy ,030104 developmental biology ,Malaltia d'Alzheimer ,Spain ,Genetic Loci ,Endophenotype ,estudio de asociación genómica completa ,Neurology (clinical) ,vascular risk ,Geriatrics and Gerontology ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. Results: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. Discussion: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series., The authors would like to thank patients and controls who participated in this project. The Genome Research @ Fundacio ACE project (GR@ACE) is supported by Fundacion bancaria La Caixa, Grifols SA, Fundacio ACE, and ISCIII (Ministry of Health, Spain). They also want to thank the private sponsors who support the basic and clinical projects of our institution (Piramal AG, Laboratorios Echevarne, Araclon Biotech S.A., and Fundacio ACE). They are indebted to the Trinitat Port-Carbo legacy and her family for their support of Fundacio ACE research programs. Fundacio ACE is a participating center in the Dementia Genetics Spanish Consortium (DEGESCO). A.R. and M.B. receive support from the European Union/EFPIA Innovative Medicines Initiative Joint undertaking ADAPTED and MOPEAD projects (grant numbers 115975 and 115985, respectively). M.B. and A.R. are also supported by national grants PI13/02434, PI16/01861, and PI17/01474. Accion Estrategica en Salud is integrated into the Spanish National R + D + I Plan and funded by ISCIII (Instituto de Salud Carlos III)-Subdireccion General de Evaluacion and the Fondo Europeo de Desarrollo Regional (FEDER-Una manera de Hacer Europa). L.M.R. is supported by Consejeria de Salud de la Junta de Andalucia (grant PI-0001/2017). Control samples and data from patients included in this study were provided in part by the National DNA Bank Carlos III (www.bancoadn.org, University of Salamanca, Spain) and Hospital Universitario Virgen de Valme (Sevilla, Spain); they were processed after standard operating procedures with the appropriate approval of the Ethical and Scientific Committee. The present work was performed as part of the Biochemistry, Molecular Biology, and Biomedicine doctoral program of S. MorenoGrau at Universitat Autonoma de Barcelona (Barcelona, Spain).r Data collection and sharing for this project was partially funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). The ADNI is funded by the National Institute on Aging and the National Institute of Biomedical Imaging and Bioengineering, as well as through generous contributions from the following: AbbVie; the Alzheimer's Association; the Alzheimer's Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company; CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Lumosity; Lundbeck; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research provides funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study was coordinated by the Alzheimer's Therapeutic Research Institute at the University of Southern California. ADNI data are disseminated by the Laboratory for NeuroImaging at the University of Southern California.; r The AddNeuroMed data are from a public-private partnership supported by EFPIA companies and SMEs as part of InnoMed (Innovative Medicines in Europe), an integrated project funded by the European Union of the Sixth Framework program priority FP6-2004-LIFESCIHEALTH-5. Clinical leads responsible for data collection are Iwona K1oszewska (Lodz), Simon Lovestone (London), Patrizia Mecocci (Perugia), Hilkka Soininen (Kuopio), Magda Tsolaki (Thessaloniki), and Bruno Vellas (Toulouse). Imaging leads are Andy Simmons (London), Lars-Olad Wahlund (Stockholm), and Christian Spenger (Zurich). Bioinformatics leads are Richard Dobson (London) and Stephen Newhouse (London).r Funding support for the Alzheimer's Disease Genetics Consortium (ADGC) was provided through the NIA Division of Neuroscience (U01-AG032984).r The Mayo Clinic Alzheimer's Disease Genetic Studies, led by Dr. Nilufer Ertekin-Taner and Dr. Steven G. Younkin at the Mayo Clinic in Jacksonville, FL, used samples from the Mayo Clinic Study of Aging, the Mayo Clinic Alzheimer's Disease Research Center, and the Mayo Clinic Brain Bank. Data collection was supported through funding by NIA grants P50 AG016574, R01 AG032990, U01 AG046139, R01 AG018023, U01 AG006576, U01 AG006786, R01 AG025711, R01 AG017216, and R01 AG003949, NINDS grant R01 NS080820, the CurePSP Foundation, and support from the Mayo Foundation.r The Neocodex-Murcia study was funded by the Fundacion Alzheimur (Murcia), the Ministerio de Educacion y Ciencia (Gobierno de Espana), Corporacion Tecnologica de Andalucia, Agencia IDEA (Consejeria de Innovacion, Junta de Andalucia), the Diabetes Research Laboratory, and the Biomedical Research Foundation. University Hospital Clinico San Carlos has been supported by CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM); CIBERDEM is an ISCIII Project.r The ROS/MAP study data were provided by the Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago. Data collection was supported through funding by NIA grants P30AG10161, R01AG15819, R01AG17917, R01AG30146, R01AG36836, U01AG32984 and U01AG46152, the Illinois Department of Public Health, and the Translational Genomics Research Institute.r The TGEN study was supported by Kronos Life Science Laboratories, the National Institute on Aging (Arizona Alzheimer's Disease Center grants P30 AG19610 and RO1 AG023193, the Mayo Clinic Alzheimer's Disease Center grant P50 AG16574, and the Intramural Research Program), the National Alzheimer's Coordinating Center (U01 AG016976), and the state of Arizona.r The authors thank the International Genomics of Alzheimer's Project (IGAP) for providing summary result data for these analyses. The investigators within IGAP contributed to the design and implementation of IGAP and/or provided data but did not participate in analysis or writing of this report. IGAP was made possible by the generous participation of the control subjects, the patients, and their families. The i-Select chip was funded by the French National Foundation on Alzheimer's disease and related disorders. European Alzheimer's Disease Initiative (EADI) was supported by the LABEX (laboratory of excellence program investment for the future) DISTALZ grant, Inserm, Institut Pasteur de Lille, Universite de Lille 2, and the Lille University Hospital. GERAD was supported by the Medical Research Council (grant no. 503480), Alzheimer's Research UK (grant no. 503176), the Wellcome Trust (grant no. 082604/2/07/Z), and German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) grant no.; 01GI0102, 01GI0711, 01GI0420. CHARGE was partly supported by the NIH/NIA grant R01 AG033193 and the NIA AG081220 and AGES contract N01-AG12100, the NHLBI grant R01 HL105756, the Icelandic Heart Association, and the Erasmus Medical Center and Erasmus University. ADGC was supported by the NIH/NIA grants: U01 AG032984, U24 AG021886, U01 AG016976, and the Alzheimer's Association grant ADGC-10-196728.
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- 2019
37. LRP10 in α-synucleinopathies
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Demis A Kia, Marya S Sabir, Sarah Ahmed, Joanne Trinh, Sara Bandres-Ciga, Alastair J Noyce, Rauan Kaiyrzhanov, Ben Middlehurst, Manuela Tan, Henry Houlden, Huw R Morris, Helene Plun-Favreau, Peter Holmans, John Hardy, Daniah Trabzuni, Jose Bras, John Quinn, Kin Y Mok, Kerri J. Kinghorn, Kimberley Billingsley, Nicholas W Wood, Patrick Lewis, Sebastian Schreglmann, Rita Guerreiro, Ruth Lovering, Lea R'Bibo, Mie Rizig, Mina Ryten, Sebastian Guelfi, Valentina Escott-Price, Viorica Chelban, Thomas Foltynie, Nigel Williams, Alexis Brice, Fabrice Danjou, Suzanne Lesage, Jean-Christophe Corvol, Maria Martinez, Claudia Schulte, Kathrin Brockmann, Javier Simón-Sánchez, Peter Heutink, Patrizia Rizzu, Manu Sharma, Thomas Gasser, Aude Nicolas, Mark R Cookson, Cornelis Blauwendraat, David W. Craig, Faraz Faghri, Raphael J. Gibbs, Dena G Hernandez, Kendall Van Keuren-Jensen, Joshua M. Shulman, Hirotaka Iwaki, Hampton L. Leonard, Mike A. Nalls, Laurie Robak, Steven Lubbe, Steven Finkbeiner, Niccolo E. Mencacci, Codrin Lungu, Andrew B Singleton, Sonja W. Scholz, Xylena Reed, Roy N. Alcalay, Ziv Gan-Or, Guy A. Rouleau, Jacobus J van Hilten, Johan Marinus, Astrid D. Adarmes-Gómez, Miquel Aguilar, Ignacio Alvarez, Victoria Alvarez, Francisco J. Barrero, Jesús A. Bergareche Yarza, Inmaculada Bernal-Bernal, Marta Blazquez, Marta Bonilla-Toribio, Juan A. Botía, María Teresa Boungiorno, Dolores Buiza-Rueda, Ana Cámara, Fátima Carrillo, Mario Carrión-Claro, Debora Cerdan, Jordi Clarimón, Monica Diez-Farien, Oriol Dols-Icardo, Jacinto Duarte, Raquel Duran, Francisco Escamilla-Sevilla, Mario Ezquerra, Cici Feliz, Manel Fernández, Rubén Fernández-Santiago, Ciara Garcia, Pedro García-Ruiz, Pilar Gómez-Garre, Maria Jose Gomez Heredia, Isabel Gonzalez-Aramburu, Ana Gorostidi Pagola, Janet Hoenicka, Jon Infante, Silvia Jesús, Adriano Jimenez-Escrig, Jaime Kulisevsky, Miguel A. Labrador-Espinosa, Jose L. Lopez-Sendon, Adolfo López de Munain Arregui, Daniel Macias, Irene Martínez Torres, Juan Marín, Maria Jose Marti, Juan Carlos Martínez- Castrillo, Carlota Méndez-del-Barrio, Manuel Menéndez González, Marina Mata, Adolfo Mínguez, Pablo Mir, Elisabet Mondragon Rezola, Esteban Muñoz, Javier Pagonabarraga, Pau Pastor, Francisco Perez Errazquin, Teresa Periñán-Tocino, Javier Ruiz-Martínez, Clara Ruz, Antonio Sanchez Rodriguez, María Sierra, Esther Suarez-Sanmartin, Cesar Tabernero, Juan Pablo Tartari, Cristina Tejera-Parrado, Eduard Tolosa, Francesc Valldeoriola, Laura Vargas-González, Lydia Vela, Francisco Vives, Alexander Zimprich, Lasse Pihlstrom, Mathias Toft, Sulev Koks, Pille Taba, and Sharon Hassin-Baer
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Lewy Body Disease ,Genetic Linkage ,Humans ,Dementia ,Lewy Bodies ,Parkinson Disease ,Neurology (clinical) - Published
- 2018
38. Reconstruction with non-vascularized fibular autograft after resection of clavicular benign tumor
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Guillermo Moreno, Daniel Macias, and Mario Cahueque
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medicine.medical_specialty ,Osteosynthesis ,Sternum ,business.industry ,Case Report ,Chondroblastoma ,medicine.disease ,Benign tumor ,Metastasis ,Surgery ,Resection ,medicine.anatomical_structure ,Clavicle ,Medicine ,Orthopedics and Sports Medicine ,Fibula ,business - Abstract
Chondroblastoma is a rare, benign cartilaginous neoplasm that accounts for approximately 1% of all bone tumors, and approximately 4% of all chondroblastomas arise in the clavicle. Here, we report a case of chondroblastoma in the right clavicle. 27-year-old female patient presented with a 12-month history of shoulder pain. Based on radiological and pathological examination, the diagnosis was compatible with chondroblastoma. After resection of the tumor, 1 cm of the distal clavicle was preserved, 15 cm of the non-vascularized fibula was taken from the contralateral leg and placed on the site of the clavicle and fixed with hook plate at distal clavicle and reconstruction plate attached to the sternum. 13 months of follow-up is scheduled for removal of osteosynthesis material, finding full consolidation of sternoclavicular segment and the distal segment. A good functional outcome was apparent after a limited 14-month follow-up, and the patient was highly satisfied with the result. We found no recurrence or metastasis.
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- 2015
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39. Effects of domain on measures of semantic relatedness
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Wilson Wong, Daniel Macias-Galindo, John Thangarajah, and Lawrence Cavedon
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Document similarity ,Information Systems and Management ,Computer Networks and Communications ,Computer science ,business.industry ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,WordNet ,Library and Information Sciences ,Semantics ,computer.software_genre ,Cohesion (linguistics) ,Semantic similarity ,Language technology ,Data mining ,Artificial intelligence ,business ,computer ,Natural language processing ,Information Systems - Abstract
Measures of semantic relatedness have been used in a variety of applications in information retrieval and language technology, such as measuring document similarity and cohesion of text. Definitions of such measures have ranged from using distance-based calculations over WordNet or other taxonomies to statistical distributional metrics over document collections such as Wikipedia or the Web. Existing measures do not explicitly consider the domain associations of terms when calculating relatedness: This article demonstrates that domain matters. We construct a data set of pairs of terms with associated domain information and extract pairs that are scored nearly identical by a sample of existing semantic-relatedness measures. We show that human judgments reliably score those pairs containing terms from the same domain as significantly more related than cross-domain pairs, even though the semantic-relatedness measures assign the pairs similar scores. We provide further evidence for this result using a machine learning setting by demonstrating that domain is an informative feature when learning a metric. We conclude that existing relatedness measures do not account for domain in the same way or to the same extent as do human judges.
- Published
- 2015
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40. On p-adic L-series, p-adic cohomology and class field theory
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David Burns and Daniel Macias Castillo
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Pure mathematics ,Non-abelian class field theory ,Galois cohomology ,Applied Mathematics ,General Mathematics ,Group cohomology ,010102 general mathematics ,Étale cohomology ,01 natural sciences ,Motivic cohomology ,Algebra ,0103 physical sciences ,De Rham cohomology ,Equivariant cohomology ,010307 mathematical physics ,0101 mathematics ,Čech cohomology ,Mathematics - Abstract
We establish several close links between the Galois structures of a range of arithmetic modules including certain natural families of ray class groups, the values at strictly positive integers of p-adic Artin L-series, the Shafarevich–Weil Theorem and the conjectural surjectivity of certain norm maps in cyclotomic ℤ p {\mathbb{Z}_{p}} -extensions. Non-commutative Iwasawa theory and the theory of organising matrices play a key role in our approach.
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- 2015
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41. On the use of photothermal techniques for the characterization of solar-selective coatings
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O. Arés-Muzio, Juan Jose Alvarado-Gil, Juan Daniel Macias, J. A. Ramirez-Rincon, Gerko Oskam, F. I. Lizama-Tzec, and M. A. Estrella-Gutiérrez
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010302 applied physics ,Materials science ,business.industry ,Energy conversion efficiency ,02 engineering and technology ,General Chemistry ,Photothermal therapy ,021001 nanoscience & nanotechnology ,Solar energy ,01 natural sciences ,0103 physical sciences ,Emissivity ,Optoelectronics ,General Materials Science ,Quantum efficiency ,Thermal emittance ,0210 nano-technology ,business ,Absorption (electromagnetic radiation) ,Photoacoustic spectroscopy - Abstract
The efficiency of the conversion of solar energy into thermal energy is determined by the optical and thermal properties of the selective coating, in particular, the solar absorptance and thermal emittance at the desired temperature of the specific application. Photothermal techniques are the most appropriate methods to explore these properties, however, a quantitative determination using photothermal radiometry, which is based on the measurement of emitted radiation caused by the heating generated by a modulated light source, has proven to be elusive. In this work, we present experimental results for selective coatings based on electrodeposited black nickel–nickel on both stainless steel and copper substrates, as well as for commercial TiNOX coatings on aluminum, illustrating that the radiation emitted by the surface depends on the optical absorption, thermal emissivity and on the light-into-heat energy conversion efficiency (quantum efficiency). We show that a combination of photothermal radiometry and photoacoustic spectroscopy can successfully account for these parameters, and provide values for the emissivity in agreement with values obtained by Fourier-transform infrared spectroscopy.
- Published
- 2018
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42. Determination of the changes on the thermal and optical properties of selective solar absorber coatings induced by prolonged thermal treatment
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Gerko Oskam, Juan Daniel Macias, Juan José Alvarado Gil, Jose Bante Guerra, Francisco I. Lizama Tzec, Hernando Romero Paredes, Dallely Melissa Herrera Zamora, Oscar Eduardo Ares Muzio, Heidi Isabel Villafan Vidales, Victor Ramos Sánchez, and Camilo Alberto Arancibia Bulnes
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Absorbance ,Materials science ,Infrared ,Thermal ,Thermal stability ,sense organs ,Thermal treatment ,Thin film ,Composite material ,Thermal diffusivity ,Refractive index - Abstract
High temperature ageing is frequently used in many technical application areas for the assessment of the thermal stability of materials; a high temperature treatment accelerates all kinds of processes, frequently performed to induce stabilization of the material. For solar absorber surfaces composed of small metal particles a high temperature treatment accelerates oxidation of the metal which in turn decreases mainly the optical properties of the coatings. Likewise changes of the surface due to machining, heat treatment, roughness and porosity can induce changes in effective thermal properties of the surface, which would affect cooling or heating process of the surface. In photothermal deflection spectroscopy (PDS) technique the sample absorbs optical radiation (pump laser) and heats the gas or liquid above the surface, the heat changes the refraction index of the fluid. A second low power laser beam is sent to probe the changes of the refraction index, in such a way that the photoinduced deviation of the probe beam are monitored using a position sensor detector. It has been shown that the beam deflection is strongly correlated to the optical and thermal properties of the materials, and it can provide important parameters as the optical absorption coefficient as well as the thermal diffusivity of the material. This non-contact technique can be particularly useful when analyzing materials in extreme conditions or when a methodology in which attachment of the sensors to the sample is not desirable or even possible. In this work, the changes of the thermal and optical properties of selective coatings exposed to a thermal treatment consisting in heating at 573 K for 200 hours, were studied using a combination of photothermal deflection spectroscopy (PDS) technique, UV/VIS/Near spectroscopy and FTIR. Samples consist of steel substrates coated with solar absorber coatings based in black cobalt and black nickel, deposited using electrochemical methods. The layer structure of black cobalt solar absorbers consisted in a bright nickel infrared reflective layer (thickness: 3.12 µm) covered with a black cobalt high solar absorbance thin film (thickness: 0.28 µm). In the same way, layer structure of black nickel solar absorbers consisted in a bright nickel infrared reflective layer (thickness: 3.12 µm) covered with a black nickel high solar absorbance thin film (thickness: 0.33 µm).
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- 2018
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43. On the Krull-Schmidt Decomposition of Mordell-Weil Groups
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Daniel Macias Castillo
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Abelian variety ,Pure mathematics ,Schmidt decomposition ,General Mathematics ,Mathematics::Number Theory ,010102 general mathematics ,Prime number ,Algebraic number field ,01 natural sciences ,11R33 ,11R34 ,0103 physical sciences ,11G35 ,010307 mathematical physics ,0101 mathematics ,Mathematics - Abstract
Let $A$ be an abelian variety defined over a number field $k$ and $p$ a prime number. Under some natural and not-too-stringent conditions on $A$ and $p$ we show that certain invariants associated to Iwasawa-theoretic $p$-adic Selmer groups control the Krull-Schmidt decompositions of the $p$-adic completions of the groups of points of $A$ over finite extensions of $k$.
- Published
- 2017
44. Grazing and neighborhood interactions limit woody encroachment in wet subtropical savannas
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Daniel Macias, Elizabeth Jacobo, and Noemí Mazía
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Biomass (ecology) ,biology ,Tussock ,Ecology ,media_common.quotation_subject ,food and beverages ,Acacia ,Subtropics ,biology.organism_classification ,Competition (biology) ,Agronomy ,Seedling ,parasitic diseases ,Grazing ,otorhinolaryngologic diseases ,Ecology, Evolution, Behavior and Systematics ,media_common ,Woody plant - Abstract
Woody encroachment in savannas is a worldwide concern, and there is growing consensus that anthropogenic activities play a central role in changing tree – grass interactions. We evaluated the influence of livestock grazing and neighborhood interactions on seedling emergence and survival of the native tree Acacia caven in wet savannas of northeastern Argentina. We hypothesized that grazing and grass competition act as biotic barriers limiting tree recruitment, but the relative magnitude of such barriers differs according to grass patch type. In two consecutive years (cohort 1 and 2) we sowed seeds and transplanted seedlings of Acacia in two grass patch types (prostrate/palatable and tussock/unpalatable grasses) in both, grazed and ungrazed plots. Each grass patch type was further manipulated to create three levels of grass competition (unclipped control, above-ground biomass removal and total biomass removal). Cattle grazing diminished seedling emergence of both cohorts and seedling survival of cohort 1. The effect of grass competition changed according to grass patch type. Prostrate grass cover enhanced emergence but lowered early survival, while tussock grass cover and also its total biomass removal facilitated early survival. During the second year, a severe drought drastically reduced Acacia recruitment, and it was strong enough to eliminate any grazing effects although the effect of grass competition on seedling establishment remained significant. Our results suggest that grazing and grass competition additively diminished the risk of woody establishment in this wet savanna. However, the stocking rate should be carefully balanced, thus contributing to the maintenance of a competitive grass cover to limit tree recruitment.
- Published
- 2014
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45. Congruences for critical values of higher derivatives of twisted Hasse–Weil L-functions
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Werner Bley and Daniel Macias Castillo
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Abelian variety ,Pure mathematics ,Conjecture ,Degree (graph theory) ,Mathematics::Number Theory ,Applied Mathematics ,General Mathematics ,010102 general mathematics ,010103 numerical & computational mathematics ,Extension (predicate logic) ,Algebraic number field ,Congruence relation ,01 natural sciences ,Prime (order theory) ,Equivariant map ,0101 mathematics ,Mathematics - Abstract
Let A be an abelian variety over a number field k and let F be a finite cyclic extension of k of p-power degree for an odd prime p. Under certain technical hypotheses, we obtain a reinterpretation of the equivariant Tamagawa number conjecture (‘eTNC’) for A, F / k $F/k$ and p as an explicit family of p-adic congruences involving values of derivatives of the Hasse–Weil L-functions of twists of A, normalised by completely explicit twisted regulators. This reinterpretation makes the eTNC amenable to numerical verification and furthermore leads to explicit predictions which refine well-known conjectures of Mazur and Tate.
- Published
- 2014
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46. Resonance frequencies and Young's modulus determination of magnetorheological elastomers using the photoacoustic technique.
- Author
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Daniel Macias, J., Ordonez-Miranda, J., and Alvarado-Gil, J. J.
- Subjects
- *
ELASTIC modulus , *ELASTOMERS , *MAGNETORHEOLOGICAL fluids , *ACOUSTOOPTICAL devices , *THERMAL expansion - Abstract
A simple and reliable methodology for determining the Young's modulus of magnetorheological elastomers is proposed based on the resonance frequencies of the amplitude of the photoacoustic signal. An explicit expression for the pressure changes within a photoacoustic cell, due to the thermal expansion of the air and the elastic bending of a clamped circular elastic membrane, is derived and analyzed. It is found that the resonance behavior of the amplitude of the photoacoustic signal is due to the contribution of the axial bending of its thickness. It is also shown that the Young's modulus of the membrane is proportional to its density, the square of its resonance frequencies and the fourth power of its radius, and inversely proportional to the square of its thickness. The application of the proposed approach to membranes made up of spherical microparticles of carbonyl iron powder embedded in a matrix of silicone rubber with weight concentrations of 0%, 5.2%, and 13.7% yields accurate and reproducible results, which are in good agreement with reported data in the literature. The highest accuracy on the measurement of the resonance frequencies and therefore on the Young's modulus is found for the first resonance peak. When a magnetic field is applied to the samples to modify their stiffness, it is observed that the Young's modulus increases with the magnetic field. This novel application of the photoacoustic technique opens the possibility of performing mechanical characterization of a broad diversity of magnetorheological membranes. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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47. Peripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease
- Author
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Laura Muñoz-Delgado, Daniel Macías-García, María Teresa Periñán, Silvia Jesús, Astrid D. Adarmes-Gómez, Marta Bonilla Toribio, Dolores Buiza Rueda, María del Valle Jiménez-Jaraba, Belén Benítez Zamora, Rafael Díaz Belloso, Sergio García-Díaz, Miguel Martín-Bórnez, Rocío Pineda Sánchez, Fátima Carrillo, Pilar Gómez-Garre, and Pablo Mir
- Subjects
Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Peripheral inflammatory immune responses are thought to play a major role in the pathogenesis of Parkinson’s disease (PD). The neutrophil-to-lymphocyte ratio (NLR), a biomarker of systemic inflammation, has been reported to be higher in patients with PD than in healthy controls (HCs). The present study was aimed at determining if the peripheral inflammatory immune response could be influenced by the genetic background of patients with PD. We included a discovery cohort with 222 patients with PD (132 sporadic PD, 44 LRRK2-associated PD (with p.G2019S and p.R1441G variants), and 46 GBA-associated PD), as well as 299 HCs. Demographic and clinical data were recorded. Leukocytes and their subpopulations, and the NLR were measured in peripheral blood. Multivariate lineal regression and post-hoc tests were applied to determine the differences among the groups. Subsequently, a replication study using the Parkinson’s Progression Markers Initiative cohort was performed which included 401 patients with PD (281 sPD patients, 66 LRRK2-PD patients, 54 GBA-PD patients) and a group of 174 HCs. Patients with sporadic PD and GBA-associated PD showed a significantly lower lymphocyte count, a non-significantly higher neutrophil count and a significantly higher NLR than HCs. The peripheral inflammatory immune response of patients with LRRK2-associated PD did not differ from HCs. Our study supports the involvement of a peripheral inflammatory immune response in the pathophysiology of sPD and GBA-associated PD. However, this inflammatory response was not found in LRRK2-associated PD, probably reflecting different pathogenic inflammatory mechanisms.
- Published
- 2023
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48. On higher order Stickelberger-type theorems
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Daniel Macias Castillo
- Subjects
Algebra ,Class (set theory) ,symbols.namesake ,Algebra and Number Theory ,Conjecture ,symbols ,Order (group theory) ,Equivariant map ,Ideal (order theory) ,Type (model theory) ,Dirichlet distribution ,Higher order derivatives ,Mathematics - Abstract
We discuss an explicit refinement of Rubinʼs integral version of Starkʼs conjecture. We prove that this refinement is a consequence of the relevant case of the Equivariant Tamagawa Number Conjecture of Burns and Flach, hence obtaining a full proof in several important cases. We also derive several explicit consequences of this refinement concerning the annihilation as Galois modules of ideal class groups by explicit elements constructed from the values of higher order derivatives of Dirichlet L-functions. We finally describe the relation between our approach and those found in recent work of Emmons and Popescu and of Buckingham.
- Published
- 2013
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49. Optical and thermal properties of selective absorber coatings under CSP conditions
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H.I. Villafán-Vidales, J. Bante-Guerra, O. Arés-Muzio, Juan Jose Alvarado-Gil, Gerko Oskam, D.M. Herrera-Zamora, Víctor H. Ramos-Sánchez, Hernando Romero-Paredes Rubio, Camilo A. Arancibia-Bulnes, Juan Daniel Macias, and F. I. Lizama-Tzec
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Work (thermodynamics) ,Materials science ,Operating temperature ,business.industry ,Thermal ,Optoelectronics ,Electric power ,business ,Thermal conduction ,Solar energy ,Solar power ,Selective surface - Abstract
Concentrating solar power (CSP) systems use solar absorbers to convert sunlight into thermal electric power. In CSP systems, a high reflective surface focuses sunlight onto a receiver that captures the solar energy and converts it into heat. The operation of high efficiency CSP systems involves improvements in the performance of the coatings of the solar absorption materials. To accomplish this, novel, more efficient selective coatings are being developed with high solar absorptance and low thermal losses at their operation temperature. Heat losses in a CSP system occur by three mechanisms: conduction, convection and radiation. It has been widely documented that energy losses increase with increasing operating temperature of CSP systems, and the precise knowledge of the thermophysical properties of the materials involved in CSP systems may allow us to increase the efficiency of systems. In this work, we applied the pulsed photoradiometry technique (PPTR) to evaluate the changes in the thermophysical prope...
- Published
- 2017
- Full Text
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50. Research Activities in Precise Positioning at Laval University
- Author
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Rock Santerre, Omid Kamali, Philippe Lamothe, Stéphanie Bourgon, Marc Cocard, Valérie Kirouac, Daniel Macias-Valadez, and Yann Prat
- Subjects
Levelling ,Engineering structures ,business.industry ,Seismic zone ,Geography, Planning and Development ,Total station ,Gps receiver ,Precise Point Positioning ,Geodesy ,Deformation monitoring ,Geography ,Global Positioning System ,business ,Earth-Surface Processes - Abstract
This review paper summarises the recent, on-going, and future research activities in precise positioning at Laval University. The projects undertaken by the GPS and Geodesy Research Group are presented following three main research topics. The first one deals with the use of precise positioning for deformation monitoring of engineering structures. The study of ice forces on dams using a robotic total station and the improvement of GPS height determination using multiple GPS antennas linked to a single receiver with calibrated fiber optics are presented. A second topic of research is the crustal deformation of the Charlevoix seismic zone in Quebec. This study uses GPS and levelling techniques and involves an investigation of the temporal stability of the GPS permanent stations available in the surrounding area. Finally, research on single GPS receiver positioning techniques is presented, namely, Precise Point Positioning (PPP) and Time Relative Positioning (TRP).
- Published
- 2012
- Full Text
- View/download PDF
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