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Aim: This study investigated the association between motor performance and somatic type, anthropometric, body composition, physiologic and physical fitness profile in young wrestlers. Material: 16 young wrestlers aging 16-19 with a 4-year-experience of taking part in national championships were selected for the study. Following the standard methods in the testing center of Alborz province some tests like aerobic power, muscular endurance, flexibility and agility speed tests and 1RM were taken to integrate the participants. Also, it should be noted that the participants’ height, weight, the girth of thigh, elbow, calf and arm and skin thickness were measured. Results: Somatotype, Somatotype Attitudinal Distance (SAD), Height Weight ratio (HWR) were calculated according to Carter and Heath anthropometric method. Body Fat Percentage (%BF), HWR and SAD resulted in 10.90±1.64, 43.27±0.87 and 0.94±0.87 respectively. Somatotype Standard Deviation and mean regarding endomorphic, mesomorphic and ectomorphic components were 2.16±0.46, 5.20±0.77 and 2.88±0.64 respectively. Physiologically, wrestlers VO2MAX (kg/min) were 49.31±4.22 and their Resting Heart Rate (bpm) were 68.31±6.64. Conclusion: As the present study illustrates, Somatotype of the Endomorphs, Mesomorphs and Ectomorphs were the same. As a result, coaches can plan wrestlers’ training programs and review of techniques based on anthropometric and physiologic data driven from their sports performances.Besides, wrestlers could be well-informed about their performance. Moreover, aforesaid information could be beneficial to wrestling federations and all other organizations contributing the wrestling federation while holding talent identification programs and recognizing young wrestlers.

Objectives Alzheimer’s disease (AD) is one of the most common problems in the elderly, which causes a decline in their cognitive function. This study aims to compare the effects of transcranial direct current stimulation (tDCS) and short-term cognitive rehabilitation on language skills and attention in older people with mild AD. Methods & Materials This is a quasi-experimental study with a pre-test/post-test/follow-up design. Participants were 60 people over 65 years of age with mild Alzheimer’s referred to a neurologist in 2022, who were selected by a convenience sampling method and were randomly assigned into two experimental groups and one control group (20 in each group). Then, the tDCS was applied in one experimental group at 10 sessions of 20 minutes once a week and the short-term cognitive rehabilitation program was provided to the second experimental group at 9 sessions of 90 minutes, once a week. No intervention was provided to the control group. Before, one week after (post-test) and one month after (follow-up) the end of the intervention, the assessments were conducted in all groups using Addenbrooke’s cognitive examination- revised (ACE-R). For data analysis, repeated measures analysis of variance test was used in SPSS software, version 23. Results Both methods improved the writing and naming domains of language skills, but they had no significant effect on the attention variable. Conclusion Both tDCS and short-term cognitive rehabilitation can be used to improve the language skills of older adults with mild AD.

Background and Objective: The coronavirus disease 2019 (COVID-19) pandemic has posed a significant threat to both healthy individuals and those with chronic diseases, including liver cirrhosis. This study aimed to evaluate the clinical and laboratory manifestations and treatment outcomes of patients with liver cirrhosis who were infected with COVID-19. Methods: This retrospective descriptive study was conducted on 9 patients (4 women and 5 men) with liver cirrhosis infected with COVID-19 hospitalized at Shahid Sayyad Shirazi Educational and Therapeutic Center in Gorgan, Iran during 2019-20. COVID-19 infection was diagnosed by a positive polymerase chain reaction (PCR) test. The Child-Pugh score was used to classify the severity of liver disease. Demographic and clinical data, including initial symptoms and complaints, laboratory results, need for intensive care unit (ICU) admission, length of hospital stay, and treatment outcomes, were extracted from patients’ medical records. Results: The severity of liver disease was classified as Class B in 7 patients. Comorbidities included cardiovascular diseases and hypertension in 2 patients each, as well as diabetes and asthma in one patient each. Clinical manifestations at the time of COVID-19 diagnosis included ascites in 6 patients; fever in 5 patients; respiratory distress and anorexia in 4 patients each; cough, oxygen saturation less than 93%, and muscle pain in 3 patients each; nausea and vomiting in 2 patients; and abdominal pain and decreased level of consciousness in one patient each. Albumin levels were less than 4 g/dL in all patients. Hemoglobin was less than 12 g/dL in 7 patients. Thrombocytopenia was observed in 8 patients, leukocytosis in one patient, and leukopenia and pancytopenia in 4 patients each. Alanine transaminase (ALT) and aspartate transaminase (AST) levels were higher than 40 U/L in 6 and 5 patients, respectively. Only one patient died, a 60-year-old woman with a history of fatty liver disease, cardiovascular disease, and uncontrolled Class C cirrhosis. Conclusion: The most common clinical manifestations in patients with liver cirrhosis infected with COVID-19 consisted of ascites, fever, respiratory distress, and anorexia, and the most common laboratory manifestations were hypoalbuminemia and thrombocytopenia.

Abstract The simulation of chemical reactions and mechanical properties including failure from atoms to the micrometer scale remains a longstanding challenge in chemistry and materials science. Bottlenecks include computational feasibility, reliability, and cost. We introduce a method for reactive molecular dynamics simulations using a clean replacement of non-reactive classical harmonic bond potentials with reactive, energy-conserving Morse potentials, called the Reactive INTERFACE Force Field (IFF-R). IFF-R is compatible with force fields for organic and inorganic compounds such as IFF, CHARMM, PCFF, OPLS-AA, and AMBER. Bond dissociation is enabled by three interpretable Morse parameters per bond type and zero energy upon disconnect. Use cases for bond breaking in molecules, failure of polymers, carbon nanostructures, proteins, composite materials, and metals are shown. The simulation of bond forming reactions is included via template-based methods. IFF-R maintains the accuracy of the corresponding non-reactive force fields and is about 30 times faster than prior reactive simulation methods.

Abstract The oil obtained from black cumin (Nigella sativa) seeds has many health-effective properties, which is used in food applications and in traditional medicine. One practical method to extract its oil is mixing with other seeds such as sunflower (Helianthus anuus) seeds before oil extraction by press. The effectiveness of the cold-press oil obtained from the mixture of black cumin seeds (BS) and sunflower seeds (SF) in different proportions 100:0, 95:5, 90:10, 85:15 and 0:100 (w/w) was studied to evaluate their qualitative properties including peroxide value (PV), acid value, p-anisidine value (AnV), pigments (carotenoid and chlorophyll) content, polyphenols, and profile of fatty acids during heating process (30–150 min at 180 °C). The results revealed that the acid and p-anisidine value of the all samples enhanced with the extension of the heating time, and the peroxide value increased at the beginning of the heating and then decreased with the prolongation of the heating time (p

Abstract Objective Define the prevalence and location of inflammatory and structural lesions on magnetic resonance imaging (MRI) in patients with rheumatoid arthritis (RA) and radiographic axial spondyloarthritis (r-axSpA) with neck pain as leading clinical symptom. Methods Patients with diagnosis of RA and r-axSpA were consecutively included if they had chronic (> 3 months) neck pain. Clinical assessment, neck pain questionnaires and MRIs of the cervical spine (CS) were performed. Results 107 patients (59 RA and 48 r-axSpA) were included. While there was no difference in the Northwick-Park-Neck-Pain-questionnaire, patients with RA reported higher neck pain compared to r-axSpA on a numeric rating scale (5.0 ± 3.6 vs. 3.0 ± 3.1; p = 0.003). Inflammatory lesions occurred predominantly in the craniocervical area in RA and in the lower CS segments in r-axSpA. Bone marrow edema (BME) was more frequent in axSpA (BME-score axSpA/RA: 0.35vs0.17; p

Shortly after the victory of the Islamic Revolution, the country witnessed the unfolding of many crises such as the emergence of counter-revolution and centrifugal crisis in some regions, including the Kurdish region, where, they grew rapidly and showed themselves in a violent form when the leadership of these currents fell into the hands of the Democratic and Komala parties, and, consequently due to the post-revolution conditions, significant parts of the Kurdish regions came under the control of the aforementioned parties in a short period of time. The dispatch of a goodwill delegation in August 1979 could not solve the problem peacefully. Therefore, military action was also put on the agenda. In judicial dimension, Sheikh Sadeq Khalkhali was sent to the Kurdish regions in late August 1979 as religious judge to play a role in confrontation with the counter-revolution and centrifugal forces. The main objective of this research is to study the degree of success of Khalkhali to participate in this confrontation and the extent to which he could prevent the crisis of centrifugal forces in the Kurdish regions. Descriptive-analytical method has been used and the necessary data has been collected from different sources. The findings of the research indicate that although Khalkhali's measures were a reaction to the counter-revolutionary measures, they did not have a decisive effect in preventing the crisis.

Abstract Physical activity promotes various metabolic benefits by balancing pro and anti-inflammatory adipokines. Recent studies suggest that asprosin might be involved in progression of metabolic syndrome (MetS), however, the underlying mechanisms have not been understood yet. This study aimed to evaluate the effects of high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), and further detraining on MetS indices, insulin resistance, serum and the liver levels of asprosin, and AMP-activated protein kinase (AMPK) pathway in menopause-induced MetS model of rats. A total of 64 Wistar rats were used in this study and divided into eight groups: Sham1, OVX1 (ovariectomized), Sham2, OVX2, OVX + HIIT, OVX + MICT, OVX + HIIT + Det (detraining), and OVX + MICT + Det. Animals performed the protocols, and then serum concentrations of asprosin, TNF-α, insulin, fasting blood glucose, and lipid profiles (TC, LDL, TG, and HDL) were assessed. Additionally, the liver expression of asprosin, AMPK, and P-AMPK was measured by western blotting. Both HIIT and MICT caused a significant decrease in weight, waist circumference, BMI (P = 0.001), and serum levels of glucose, insulin, asprosin (P = 0.001), triglyceride, total cholesterol, low-density lipoprotein (LDL), and TNF-α (P = 0.001), but an increase in the liver AMPK, P-AMPK, and P-AMPK/AMPK (P = 0.001), compared with OVX2 noexercised group. MICT was superior to HIIT in reducing serum asprosin, TNF-a, TG, LDL (P = 0.001), insulin, fasting blood glucose, HOMA-IR, and QUEKI index (P = 0.001), but an increase in the liver AMPK, and p-AMPK (P = 0.001). Although after two months of de-training almost all indices returned to the pre exercise values (P

The primary aim of this study was to develop biocomposite films using carboxymethyl cellulose (CMC) (1 % w/v), okra mucilage (OM) (1–3 % w/v), and black cumin seed oil (BSO) (0–0.5 % v/v), based on the central composite design. The effects of OM and BSO concentrations on the properties of biocomposite films were evaluated using response surface methodology. Statistical analysis showed that all variables significantly contribute to the model (p < 0.05). The findings indicated that higher BSO concentrations considerably decreased (p < 0.05) the water vapor and oxygen permeability, moisture content, swelling factor, and water solubility of the produced films. Conversely, a rise in OM concentration notably increased (p < 0.05) the physical and barrier properties of the films. It was determined that an increase in OM concentration led to a decrease in tensile strength (TS), while the elongation at break (%EB) increased significantly (p < 0.05). Conversely, higher concentrations of BSO significantly improved both the TS and %EB values (p < 0.05). FE-SEM analysis revealed that for all films, microstructural irregularities increased with higher concentrations of OM and BSO. The formulation containing 1.82 % OM and 0.5 % BSO was identified as an optimal composition. FE-SEM and AFM analyses showed that the optimal film had higher microstructural discontinuity and surface roughness than the control film. The optimal film exhibited significantly higher antioxidant activity (p < 0.05) compared to the control film. Furthermore, FTIR analysis highlighted the presence of new intermolecular interactions within the functional groups of the optimal film’s matrix. Moreover, the optimal film demonstrated a higher melting temperature and a more amorphous structure than the control film. In conclusion, the optimized CMC/OM/BSO film presents promising potential for use in edible packaging.

The aim of this study was to compare the efficacy of Affective Reconstructive and Emotional-Focused therapy with regard to marriage issues and forgiveness in women who filled for a divorce. The research method is applied in terms of purpose and semi-experimental research design is pre-test-post-test with a control group and follow-up stage. In 2021, the statistical population comprised all Ardabil women who filed for divorce and had a prior record of child marriage (less than 18 years). The population was purposively sampled to select 45 individuals, who were then randomly allocated into two groups of 15 (one for each group: experimental and control). The research instruments included the Interpersonal Forgiveness Scale (IF-25) and the Marriage Problems Questionnaire (PMQ). The interventions comprised eight 90-minute sessions per week, each centered on affective reconstruction and emotional-focused therapy. SPSS software version 22 was utilized to conduct the data analysis, which included multivariate analysis of covariance (MANCOVA) and the Bonferroni post hoc test. The results showed that in women who filed for divorce, both affective reconstruction and emotional-focused therapy increased forgiveness and decreased marital problems; however, affective reconstruction therapy demonstrated a significantly greater degree of efficacy than emotional-focused therapy. Hence, in light of the elevated marital issues and diminished forgiveness rates observed among women who have filed for divorce, affective reconstruction and emotional-focused therapies, or a synergistic blend thereof, may be implemented to improve the forgiveness rate and mitigate marital problems.

Background: In addition to physical problems, infertile couples face psychological issues during treatment. This study aimed to investigate the effect of healing codes training on the sexual self-esteem of infertile women.Methods: The present study employed a quasi-experimental pre-test, post-test, follow-up design with a control group and an experimental group. Convenience sampling method was used to recruit forty infertile women satisfying the inclusion criteria from fertility treatment centers in Isfahan, Iran in 2023. Participants were randomly assigned into either the experimental group (n=20) or the control group (n=20). The experimental group received a standardized 14-week intervention consisting of weekly 90-minute training sessions focused on a specific therapeutic technique (healing codes). Data analysis was conducted using repeated-measures ANOVA.Results: The results demonstrated a statistically significant increase in sexual self-esteem scores in the experimental group compared with the control group (P=0.001) at both the post-test and follow-up phases. No significant difference was observed between the groups at pre-test. Throughout the study, the mean scores for the experimental group (post-test: 110.13±6.71, follow-up: 110.32±6.93) were significantly higher than the control group (post-test: 91.93±11.40, follow-up: 94.74±17.12). These findings suggested that healing codes training led to a significant difference in sexual self-esteem between the experimental and control groups (P=0.001).Conclusions: This study provided evidence that healing codes training leads to a significant improvement in sexual self-esteem among infertile women. These findings suggested that healing codes training may be a promising new approach to improve the psychological well-being of infertile women.

Prolactin (PRL) is elevated in B-cell-mediated lymphoproliferative diseases and promotes B-cell survival. Whether PRL or PRL receptors drive the evolution of B-cell malignancies is unknown. We measure changes in B cells after knocking down the pro-proliferative, anti-apoptotic long isoform of the PRL receptor (LFPRLR) in vivo in systemic lupus erythematosus (SLE)- and B-cell lymphoma-prone mouse models, and the long plus intermediate isoforms (LF/IFPRLR) in human B-cell malignancies. To knockdown LF/IFPRLRs without suppressing expression of the counteractive short PRLR isoforms (SFPRLRs), we employ splice-modulating DNA oligomers. In SLE-prone mice, LFPRLR knockdown reduces numbers and proliferation of pathogenic B-cell subsets and lowers the risk of B-cell transformation by downregulating expression of activation-induced cytidine deaminase. LFPRLR knockdown in lymphoma-prone mice reduces B-cell numbers and their expression of BCL2 and TCL1. In overt human B-cell malignancies, LF/IFPRLR knockdown reduces B-cell viability and their MYC and BCL2 expression. Unlike normal B cells, human B-cell malignancies secrete autocrine PRL and often express no SFPRLRs. Neutralization of secreted PRL reduces the viability of B-cell malignancies. Knockdown of LF/IFPRLR reduces the growth of human B-cell malignancies in vitro and in vivo. Thus, LF/IFPRLR knockdown is a highly specific approach to block the evolution of B-cell neoplasms.

Olive oils have high consumption due to their health benefits and also owe higher economic value and a grwing demand in the market. However, blending lower grade oils with virgin olive oil can harm its nutritional value and market value. There are valuable reviews on the conventional methods on the detection of olive oils adulteration, but this review focuses on recent literatures on the detection this adulteration through advanced coupling analytical techniques, emphasizing the application of chemometrics in olive oil research.Recent studies have successfully improved the detection limit by combining different methods or modifying existing ones. Each technique has its own strengths and limitations, making them more suitable for specific types of adulteration. The integration of new and advanced detection methods, along with the use of chemometrics, was not found in earlier review research papers. NMR reveals the chemical composition and structure of the oils, while chromatography separates and identifies individual components. DNA-based methods detect genetic material, and electronic nose detects differences in odor or taste. In practice, a combination of multiple analytical techniques enhances the accuracy and reliability of detecting olive oil adulteration. Chemometrics, a mathematical and statistical approach to analyzing large datasets, helps interpret the results and identify patterns and trends that may indicate adulteration.

_ Cocoa butter is a highly prized and versatile product with a wide range of applications. It is a crucial component of chocolate due to its unique melting properties and ability to dissolve other ingredients. Therefore, it is essential to evaluate the compositional characteristics of cocoa butter from different sources to ensure its quality and authenticity. This study aimed to analyze the triacylglycerols, fatty acids, sterols, sterene compounds, extinction coefficient, and Solid Fat Content (SFC) of cocoa butter from nine diverse samples. The findings revealed that the main triacylglycerols were POP (16.07-17.74), SOS (25.73-28.91), and POS (39.12-40.25), while the primary fatty acids were palmitic (26.25-28.96), stearic (32.46-35.64), and oleic acids (31.51-32.47). The dominant sterols were (55.04-56.98 %), stigmasterol (25.4-26.2 %), and campesterol (9.22-10.53 %), with the ratio of stigmasterol to campesterol (2.5 to 2.7) serving as an indicator of authenticity. The study also found minimal levels of stigmastadiene (0.0001–0.0039 ppm), indicating low oxidation products, and measured the SFC content at different temperatures. Overall, this comprehensive analysis provides valuable insights into the composition of cocoa butter from various sources, offering important information for quality control and detection of adulteration.

Sesame oil has been widely used in the daily diet due to its high nutritional value. Sesame oil is extracted at industrial scales and also in small scale by cold pressing at different temperatures. In this research, sesame oil was extracted by pressing at four temperatures, namely, 30 (control sample), 60, 90 and 120 °C, to evaluate its effects on the quality of extracted oils. Oil extraction yields were increased from 38 to 51% by increasing the pressing temperature. The highest amount of peroxide and acid values were related to the oil extracted at 120 °C. Tocopherols and total phenol content were reduced by the increasing the pressing temperature, and the highest amounts of these bioactive components were related to the control sample. The results of the fatty acids profile showed that the composition of oils extracted at different temperatures did not differ significantly (p > 0.05). The results of the present study give a clear picture about the effects of different pressing temperatures on the sesame oil quality and extraction yield, and can be useful in the extraction unit optimization.