1. Hedgehog morphogen: from secretion to reception
- Author
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Armel Gallet, Institute of Developmental Biology and Cancer (IBDC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and CNRS
- Subjects
Cell signaling ,animal structures ,Receptors, Cell Surface ,MYOGENIC DIFFERENTIATION ,GPI-ANCHORED PROTEINS ,03 medical and health sciences ,0302 clinical medicine ,LONG-RANGE ACTIVITY ,CELL-SURFACE ,Animals ,Humans ,Secretion ,Hedgehog Proteins ,Sonic hedgehog ,DALLY-LIKE ,Hedgehog ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,030304 developmental biology ,CHOLESTEROL MODIFICATION ,0303 health sciences ,biology ,SONIC HEDGEHOG ,Cell Biology ,Anatomy ,Hedgehog signaling pathway ,Cell biology ,embryonic structures ,biology.protein ,SIGNALING PATHWAY ,DROSOPHILA ORTHOLOG ,Signal transduction ,CAENORHABDITIS-ELEGANS ,Developmental biology ,030217 neurology & neurosurgery ,Morphogen ,Protein Binding ,Signal Transduction - Abstract
International audience; A major challenge of developmental biology is to understand how cells coordinate developmental behaviors with their neighbors. To achieve this, cells often employ signaling molecules that emanate from a local source and act at a distance on target cells. The Hedgehog morphogen is an essential signaling molecule required for numerous processes during animal development. Emphasizing the importance of this molecule for both growth control and patterning, Hedgehog signaling activity is often deregulated during cancer formation and progression. The secretion and spread of Hedgehog are not passive processes, but require accessory molecules involved in Hedgehog processing, release, spread and reception. In this review, I focus on the factors that are required to control the spread and activity of Hedgehog, highlighting recent data that have shed light on these processes.
- Published
- 2011