Back to Search
Start Over
Hedgehog morphogen: from secretion to reception
- Source :
- Trends in Cell Biology, Trends in Cell Biology, Elsevier, 2011, 21 (4), epub ahead of print. ⟨10.1016/j.tcb.2010.12.005⟩, Trends in Cell Biology, Elsevier, 2011, epub ahead of print. ⟨10.1016/j.tcb.2010.12.005⟩
- Publication Year :
- 2011
- Publisher :
- HAL CCSD, 2011.
-
Abstract
- International audience; A major challenge of developmental biology is to understand how cells coordinate developmental behaviors with their neighbors. To achieve this, cells often employ signaling molecules that emanate from a local source and act at a distance on target cells. The Hedgehog morphogen is an essential signaling molecule required for numerous processes during animal development. Emphasizing the importance of this molecule for both growth control and patterning, Hedgehog signaling activity is often deregulated during cancer formation and progression. The secretion and spread of Hedgehog are not passive processes, but require accessory molecules involved in Hedgehog processing, release, spread and reception. In this review, I focus on the factors that are required to control the spread and activity of Hedgehog, highlighting recent data that have shed light on these processes.
- Subjects :
- Cell signaling
animal structures
Receptors, Cell Surface
MYOGENIC DIFFERENTIATION
GPI-ANCHORED PROTEINS
03 medical and health sciences
0302 clinical medicine
LONG-RANGE ACTIVITY
CELL-SURFACE
Animals
Humans
Secretion
Hedgehog Proteins
Sonic hedgehog
DALLY-LIKE
Hedgehog
[SDV.BDD]Life Sciences [q-bio]/Development Biology
030304 developmental biology
CHOLESTEROL MODIFICATION
0303 health sciences
biology
SONIC HEDGEHOG
Cell Biology
Anatomy
Hedgehog signaling pathway
Cell biology
embryonic structures
biology.protein
SIGNALING PATHWAY
DROSOPHILA ORTHOLOG
Signal transduction
CAENORHABDITIS-ELEGANS
Developmental biology
030217 neurology & neurosurgery
Morphogen
Protein Binding
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 09628924
- Database :
- OpenAIRE
- Journal :
- Trends in Cell Biology, Trends in Cell Biology, Elsevier, 2011, 21 (4), epub ahead of print. ⟨10.1016/j.tcb.2010.12.005⟩, Trends in Cell Biology, Elsevier, 2011, epub ahead of print. ⟨10.1016/j.tcb.2010.12.005⟩
- Accession number :
- edsair.doi.dedup.....fc3e3fdf9c7e5879bd8dc571150601d7