1. Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance
- Author
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Papon, Nicolas, Noël, Thierry, Florent, Martine, Gibot-Leclerc, Stéphanie, Jean, Dorothée, Chastin, Christiane, Villard, Jean, Chapeland-Leclerc, Florence, Laboratoire des Sciences de l'Image, de l'Informatique et de la Télédétection (LSIIT), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)
- Subjects
MESH: Sequence Analysis, DNA ,MESH: Mutation ,Antifungal Agents ,Molecular Sequence Data ,MESH: Flucytosine ,Flucytosine ,Microbial Sensitivity Tests ,MESH: Drug Resistance, Fungal ,Cytosine Deaminase ,Fungal Proteins ,MESH: Plasmids ,MESH: Candida ,Mechanisms of Resistance ,Drug Resistance, Fungal ,MESH: Cloning, Molecular ,Pentosyltransferases ,Cloning, Molecular ,DNA, Fungal ,Fluconazole ,Drug Resistance, Fungal/genetics ,Fluconazole/pharmacology ,Alleles ,MESH: Pentosyltransferases ,Candida ,MESH: Genetic Complementation Test ,MESH: Microbial Sensitivity Tests ,Plasmids/genetics ,MESH: Molecular Sequence Data ,MESH: Alleles ,MESH: Cytosine Deaminase ,Genetic Complementation Test ,Sequence Analysis, DNA ,Pentosyltransferases/genetics ,MESH: Antifungal Agents ,DNA, Fungal/chemistry/genetics ,MESH: DNA, Fungal ,Flucytosine/pharmacology ,Fungal Proteins/genetics ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Mutation ,Antifungal Agents/pharmacology ,Candida/drug effects/enzymology/genetics ,Fluorouracil/pharmacology ,MESH: Fluconazole ,MESH: Fungal Proteins ,Fluorouracil ,Cytosine Deaminase/genetics ,MESH: Fluorouracil ,Plasmids - Abstract
International audience; Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.
- Published
- 2007
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