Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance

Authors :: Papon, Nicolas
Noël, Thierry
Florent, Martine
Gibot-Leclerc, Stéphanie
Jean, Dorothée
Chastin, Christiane
Villard, Jean
Chapeland-Leclerc, Florence
Laboratoire des Sciences de l'Image, de l'Informatique et de la Télédétection (LSIIT)
Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)
Source :: Antimicrobial Agents and Chemotherapy, Vol. 51, No 1 (2007) pp. 369-371, Antimicrobial Agents and Chemotherapy, Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2007, 51 (1), pp.369-71. ⟨10.1128/AAC.00824-06⟩
Publication Year :: 2007
Abstract: International audience; Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.

Subjects :: MESH: Sequence Analysis, DNA
MESH: Mutation
Antifungal Agents
Molecular Sequence Data
MESH: Flucytosine
Flucytosine
Microbial Sensitivity Tests
MESH: Drug Resistance, Fungal
Cytosine Deaminase
Fungal Proteins
MESH: Plasmids
MESH: Candida
Mechanisms of Resistance
Drug Resistance, Fungal
MESH: Cloning, Molecular
Pentosyltransferases
Cloning, Molecular
DNA, Fungal
Fluconazole
Drug Resistance, Fungal/genetics
Fluconazole/pharmacology
Alleles
MESH: Pentosyltransferases
Candida
MESH: Genetic Complementation Test
MESH: Microbial Sensitivity Tests
Plasmids/genetics
MESH: Molecular Sequence Data
MESH: Alleles
MESH: Cytosine Deaminase
Genetic Complementation Test
Sequence Analysis, DNA
Pentosyltransferases/genetics
MESH: Antifungal Agents
DNA, Fungal/chemistry/genetics
MESH: DNA, Fungal
Flucytosine/pharmacology
Fungal Proteins/genetics
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Mutation
Antifungal Agents/pharmacology
Candida/drug effects/enzymology/genetics
Fluorouracil/pharmacology
MESH: Fluconazole
MESH: Fungal Proteins
Fluorouracil
Cytosine Deaminase/genetics
MESH: Fluorouracil
Plasmids

Language :: English
ISSN :: 00664804 and 10986596
Database :: OpenAIRE
Journal :: Antimicrobial Agents and Chemotherapy, Vol. 51, No 1 (2007) pp. 369-371, Antimicrobial Agents and Chemotherapy, Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2007, 51 (1), pp.369-71. ⟨10.1128/AAC.00824-06⟩
Accession number :: edsair.pmid.dedup....2ba24ff0f0ba7af192ab872ec7082246
Full Text :: https://doi.org/10.1128/AAC.00824-06⟩

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