1. Is inflammation a direct response to dsDNA breaks?
- Author
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Shahid Chaudhary, Gorantla V. Raghuram, and Indraneel Mittra
- Subjects
Inflammation ,0301 basic medicine ,Chemistry ,DNA damage ,Health, Toxicology and Mutagenesis ,Direct response ,Genome ,Cell biology ,Proinflammatory cytokine ,Chromatin ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Dna breaks ,Genetics ,medicine ,Humans ,DDR Proteins ,DNA Breaks, Double-Stranded ,medicine.symptom ,Molecular Biology - Abstract
Recent research shows that extra-nuclear cell-free chromatin (cfCh) released from dying cells can freely enter into healthy cells and integrate into their genomes. Genomic integration of cfCh leads to dsDNA breaks and activation of inflammatory cytokines both of which occur concurrently with similar kinetics and that induction of inflammation can be abrogated by preventing DNA breaks with the use of cfCh inactivating agents. The proposal is put forward that inflammatory cytokines are a new family of DDR proteins that are activated following dsDNA breaks inflicted by genomic integration of cfCh.
- Published
- 2018