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Advances in therapeutic targeting of the DNA damage response in cancer
- Publication Year :
- 2018
-
Abstract
- The DNA damage response (DDR) is a series of pathways and processes required to repair lesions to DNA. These pathways range from repairing strand breaks to the double helix, damaged bases formed after oxidation or deamination, inaccurate DNA replication resulting in mispaired base alignment, intrastrand crosslinks that trigger cell death, and a plethora of other genomic insults. The DDR is believed to be a critical component of radio and chemoresistance in many cancers as well, with the tumor's ability to repair therapy induced damage being an important tool used to survive traditional chemotherapeutic agents. Here we summarize advances made in specifically targeting DDR proteins in cancer therapy and project on the potential breakthroughs and pitfalls to arise as the field progresses.
- Subjects :
- 0301 basic medicine
Programmed cell death
DNA Repair
DNA damage
Cancer therapy
Antineoplastic Agents
Biology
Therapeutic targeting
Biochemistry
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Neoplasms
medicine
Humans
Molecular Biology
DNA replication
Cancer
Cell Biology
DNA
medicine.disease
body regions
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Cancer research
DDR Proteins
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....9bdacfc2003c94e019584fe88edbab96