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1. Joint Analysis of BICEP2/Keck ArrayandPlanckData

Author: P. A. R. Ade, N. Aghanim, Z. Ahmed, R. W. Aikin, K. D. Alexander, M. Arnaud, J. Aumont, C. Baccigalupi, A. J. Banday, D. Barkats, R. B. Barreiro, J. G. Bartlett, N. Bartolo, E. Battaner, K. Benabed, A. Benoît, A. Benoit-Lévy, S. J. Benton, J.-P. Bernard, M. Bersanelli, P. Bielewicz, C. A. Bischoff, J. J. Bock, A. Bonaldi, L. Bonavera, J. R. Bond, J. Borrill, F. R. Bouchet, F. Boulanger, J. A. Brevik, M. Bucher, I. Buder, E. Bullock, C. Burigana, R. C. Butler, V. Buza, E. Calabrese, J.-F. Cardoso, A. Catalano, A. Challinor, R.-R. Chary, H. C. Chiang, P. R. Christensen, L. P. L. Colombo, C. Combet, J. Connors, F. Couchot, A. Coulais, B. P. Crill, A. Curto, F. Cuttaia, L. Danese, R. D. Davies, R. J. Davis, P. de Bernardis, A. de Rosa, G. de Zotti, J. Delabrouille, J.-M. Delouis, F.-X. Désert, C. Dickinson, J. M. Diego, H. Dole, S. Donzelli, O. Doré, M. Douspis, C. D. Dowell, L. Duband, A. Ducout, J. Dunkley, X. Dupac, C. Dvorkin, G. Efstathiou, F. Elsner, T. A. Enßlin, H. K. Eriksen, E. Falgarone, J. P. Filippini, F. Finelli, S. Fliescher, O. Forni, M. Frailis, A. A. Fraisse, E. Franceschi, A. Frejsel, S. Galeotta, S. Galli, K. Ganga, T. Ghosh, M. Giard, E. Gjerløw, S. R. Golwala, J. González-Nuevo, K. M. Górski, S. Gratton, A. Gregorio, A. Gruppuso, J. E. Gudmundsson, M. Halpern, F. K. Hansen, D. Hanson, D. L. Harrison, M. Hasselfield, G. Helou, S. Henrot-Versillé, D. Herranz, S. R. Hildebrandt, G. C. Hilton, E. Hivon, M. Hobson, W. A. Holmes, W. Hovest, V. V. Hristov, K. M. Huffenberger, H. Hui, G. Hurier, K. D. Irwin, A. H. Jaffe, T. R. Jaffe, J. Jewell, W. C. Jones, M. Juvela, A. Karakci, K. S. Karkare, J. P. Kaufman, B. G. Keating, S. Kefeli, E. Keihänen, S. A. Kernasovskiy, R. Keskitalo, T. S. Kisner, R. Kneissl, J. Knoche, L. Knox, J. M. Kovac, N. Krachmalnicoff, M. Kunz, C. L. Kuo, H. Kurki-Suonio, G. Lagache, A. Lähteenmäki, J.-M. Lamarre, A. Lasenby, M. Lattanzi, C. R. Lawrence, E. M. Leitch, R. Leonardi, F. Levrier, A. Lewis, M. Liguori, P. B. Lilje, M. Linden-Vørnle, M. López-Caniego, P. M. Lubin, M. Lueker, J. F. Macías-Pérez, B. Maffei, D. Maino, N. Mandolesi, A. Mangilli, M. Maris, P. G. Martin, E. Martínez-González, S. Masi, P. Mason, S. Matarrese, K. G. Megerian, P. R. Meinhold, A. Melchiorri, L. Mendes, A. Mennella, M. Migliaccio, S. Mitra, M.-A. Miville-Deschênes, A. Moneti, L. Montier, G. Morgante, D. Mortlock, A. Moss, D. Munshi, J. A. Murphy, P. Naselsky, F. Nati, P. Natoli, C. B. Netterfield, H. T. Nguyen, H. U. Nørgaard-Nielsen, F. Noviello, D. Novikov, I. Novikov, R. O’Brient, R. W. Ogburn, A. Orlando, L. Pagano, F. Pajot, R. Paladini, D. Paoletti, B. Partridge, F. Pasian, G. Patanchon, T. J. Pearson, O. Perdereau, L. Perotto, V. Pettorino, F. Piacentini, M. Piat, D. Pietrobon, S. Plaszczynski, E. Pointecouteau, G. Polenta, N. Ponthieu, G. W. Pratt, S. Prunet, C. Pryke, J.-L. Puget, J. P. Rachen, W. T. Reach, R. Rebolo, M. Reinecke, M. Remazeilles, C. Renault, A. Renzi, S. Richter, I. Ristorcelli, G. Rocha, M. Rossetti, G. Roudier, M. Rowan-Robinson, J. A. Rubiño-Martín, B. Rusholme, M. Sandri, D. Santos, M. Savelainen, G. Savini, R. Schwarz, D. Scott, M. D. Seiffert, C. D. Sheehy, L. D. Spencer, Z. K. Staniszewski, V. Stolyarov, R. Sudiwala, R. Sunyaev, D. Sutton, A.-S. Suur-Uski, J.-F. Sygnet, J. A. Tauber, G. P. Teply, L. Terenzi, K. L. Thompson, L. Toffolatti, J. E. Tolan, M. Tomasi, M. Tristram, M. Tucci, A. D. Turner, L. Valenziano, J. Valiviita, B. Van Tent, L. Vibert, P. Vielva, A. G. Vieregg, F. Villa, L. A. Wade, B. D. Wandelt, R. Watson, A. C. Weber, I. K. Wehus, M. White, S. D. M. White, J. Willmert, C. L. Wong, K. W. Yoon, D. Yvon, A. Zacchei, and A. Zonca
Published: 2015
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2. STUDIO PRELIMINARE SU UN NUOVO METODO PER LA VALUTAZIONE DELLE PRESTAZIONI DEI SISTEMI COLOR DOPPLER PER LA DIAGNOSTICA CLINICA

Author: A. Scorza, D. Pietrobon, F. Orsini, S. A. Sciuto, Luigi Rovati, Stefano Cattini, Scorza, A., Pietrobon, D., Orsini, F., and Sciuto, S. A.
Abstract: Sebbene il Color Flow Imaging ad ultrasuoni (CFI) sia una tecnologia molto utilizzata in ambito clinico, ad oggi se da un lato non è ancora possibile identificare uno standard condiviso a livello internazionale in merito alla verifica completa e dettagliata delle prestazioni delle macchine che ne fanno uso, dall’altro appare comunque estremamente difficile individuare anche nella letteratura scientifica del settore una linea comune sulla scelta dei parametri da verificare così come dei metodi di misura e della tempistica delle prove. Dopo una breve introduzione ai sistemi diagnostici CFI e alla loro verifica, si propone un metodo basato sull’utilizzo di un fantoccio per ultrasuoni a tubi di flusso e sull’analisi delle corrispondenti immagini CFI prodotte dall’apparecchiatura in esame. I risultati dell’applicazione del metodo ad un sistema ecografico commerciale vengono infine riportati e commentati, dimostrando valori coerenti con quanto riscontrabile nella letteratura tecnico-scientifica.
Published: 2017

3. Abstract

Author: L. J. Andries, S. U. Sys, A. L. Meulemans, J. A. J. Schuurkes, B. Vanheel, J. Van de Voorde, P. De Smet, J. Li, W. Van Driessche, B. Flamion, S. Foulon, M. Abramow, P. Calders, W. Eechaute, E. Lacroix, I. Weyne, D. Hoeben, C. Burvenich, P. Fransen, D. Van Bedaf, M. Demolder, R. Ouedraogo, P. Lebrun, A. Herchuelz, M. -H. Antoine, S. Vandenput, D. Votion, N. Anciaux, D. H. Duvivier, T. Art, P. Lekeux, Y. Ghafir, M. Geurts, E. Hermans, J. -M. Maloteaux, B. Perrad, B. Noel, F. Lagache, J. L. Bister, R. Paquay, G. Derycke, M. A. Vandermeir, S. de Brouwer, C. -A. Porret, N. Stergiopulos, J. -J. Meister, M. Verbeke, N. Lameire, N. M. De Clerck, J. De Schuytter, J. Tytgato, G. Buyse, J. Eggermont, G. Droogmans, B. Nilius, P. Daenens, S. Salomone, O. Feron, C. Dessy, N. Morel, T. Godfraind, A. M. Aloisi, P. Sacerdote, L. Lodi, G. Carli, C. Carobi, G. Garinei, U. C. Miniaci, P. Scotto, M. Sabatino, P. Sardo, L. Iurato, V. La Grutta, M. A. Bagni, G. Cecchi, E. Cecchini, F. Colomo, P. Garzella, R. Bottinelli, S. D. H. Harridge, M. Canepari, C. Reggiani, Saltin Reggiani, D. Bambagioni, G. Fanò, G, Menchetti, P. Danieli-Betto, A. Esposito, R. Betto, A. Megighian, M. Midrio, D. Danieli Betto, C. Orizio, D. Liberati, C. Locatelli, D. De Grandis, A. Veicsteinas, D. Angoli, D. Delia, E. Wanke, M. Bramucci, A. Miano, L. Quassinti, E. Maccari, O. Murri, D. Amici, G. Cibelli, S. Jüngling, S. Schoch, H. H. Gerdest, G. Thiel, I. Demori, C. Bottazzi, A. Voci, E. Fugassa, A. Barreca, F. Minuto, G. Gallo, S. Fulle, S. Belia, G. Menchetti, M. Cacchio, G. Gastaldi, U. Laforenza, G. Ferrari, G. Rindi, M. G. Doni, E. Padoin, O. Residori, M. Cesaro, L. Toma, A. Rubini, F Mutinelli, L. Paulesu, R. Romagnolie, M. Cintorino, P. Pippia, M. A. Meloni, L. Sciola, A. Spano, M. Cogoli-Greuter, A. Cogoli, A. Sardini, G. M. Mintenig, M. A. Valverde, F. V. Sepùlveda, D. R. Gill, S. C. Hyde, C. F. Higgins, P. A. McNaughton, A. Spena, M. T. Arcuri, S. Bonofiglio, R. Chimenti, C. Covello, T. De Cicco, S. Mazzulla, G. Martino, A. Tottene, A. Moretti, D. Pietrobon, M. C. Baccari, F. Calamai, G. Staderini, E. Cova, R. Marelli, P. Sommi, U. Ventura, A. M. Lombardi, R. Fabris, C. Pagano, G. Federspil, R. Vettor, R. Mancinelli, P. Tonali, S. Servidei, R. Romani, A. Tringali, G. B. Azzena, F. Mulè, R. Serio, A. Postorino, M. Rizzato, M. Granzotto, V. Ricci, M. Romano, K. J. Ivey, G. Vacca, B. Papillo, D. A. S. G. Mary, A. Battaglia, E. Grossini, E. A. Accili, G. Redaelli, D. DiFrancesco, S. Antoniotti, C. Distasi, D. Lovisolo, L. Munaron, F. Bertaso, R. Assandri, M. Mazzanti, L. Bianchi, A. Arcangeli, L. Faravelli, A. Becchetti, M. Coronello, E. Mini, F. Francini, M. Olivotto, A. Bigiani, D. -J. Kim, S. D. Roper, V. Carabelli, M. Lovallo, V. Magnelli, H. Zucker, E. Carbone, E. D’Angelo, P. Rossi, G. De Filippi, V. Taglietti, C. Bencini, R. Squecco, E. Guatteo, A. Bacci, S. Franceschetti, G. Avanzini, A. Ferroni, A. Navangione, V. Vellani, G. Rispoli, A. Peres, E. Centinaio, S. Giovannardi, G. Russo, W. Marcotti, I. Prigioni, C. Trequattrini, A. A. Harper, A. Petris, F. Franciolini, A. Zaza, M. Micheletti, A. Brioschi, G. Antonutto, C. Capelli, M. Girardis, P. Zamparo, P. E. di Prampero, D. Tuniz, G. M. Filippi, D. Troiani, B. Grassi, D. C. Poole, R. S. Richardson, D. R. Knight, B. K. Erickson, P. D. Wagner, B. Aimi, D. Stilli, P. Gallo, A. Sgoifo, C. Lagrasta, G. Olivetti, N. Reali, A. Casti, E. Musso, G. Alloatti, C. Penna, M. P. Gallo, R. C. Levi, I. Fenoglio, G. Appendino, D. Medici, M. Manghi, E. Pasini, C. Ceconi, F. Baldissera, P. Cavallari, M. Locatelli, R. Bartesaghi, T. Gessi, F. Benfenati, F. Valtorta, F. Onofri, M. Poo, P. Greengard, G. Biagini, D. Sala, P. Viani§, A. V. Kozlov, I. Zini, M. Bravin, F. Tempia, P. Strata, G. Brescia, C. Di Benedetto, P. Corsi, G. Cangiano, M. Buttiglione, M. Ambrosini, G. Gennarini, A. Casadio, P. G. Montarolo, P. Cesare, R. Stoughton, G. D’Arcangelo, H. U. Dodt, A. Brancati, W. Zieglgänsberger, P. Errico, A. Ferraresi, N. H. Barmack, V. E. Pettorossi, S. Gasparini, R. D’Ambrosio, D. Janigro, I. Gritti, M. Marintti, R. Calcaterra, R. Freddi, M. Mancia, I. Imeri, S. Bianchi, F. Lui, K. M. Gregory, R. H. I. Blanks, R. A. Giolli, C. Benassi, R. Corazza, P. C. Magherini, R. Bardoni, O. Belluzzi, E. Manni, M. Diana, W. Fratta, D. Manzoni, P. Andre, O. Pompeiano, R. Mazzocchio, A. Rossi, F. Melis, A. Kitura, M. A. Caria, H. Asanuma, M Melone, S De Biasi, A Minelli, F Conti, C Karschin, S DeBiasi, N C Brecha, M. Monda, S. Amaro, A. Sullo, B. De Luca, M. R. Pantò, F. Cicirata, R. Parenti, M. F. Serapide, M. Wassef, M. V. Podda, A. Solinas, G. Chessa, F. Deriu, O. Mameli, E. Tolu, C. A. Porro, M. P. Francescato, V. Cettolo, M. E. Diamond, P. Baraldi, M. Bazzocchi, R. Rivosecchi, A. Konnerth, M. L. Rossi, M. Martini, B. Pelucchi, R. Fesce, L. Santarelli, S. Schacher, R. Santarelli, C. Grassi, A. Valente, S. Nisticò, G. Bagetta, Rossana Scuri, Mercedes Garcia-Gil, Riccardo Mozzachiodi, Marcello Brunelli, G. Stefani, P. Vaccaro, H. B. Nielander, V. Tancredi, M. D’Antuono, A. Siniscalchi, M. Avoli, L. Verzè, A. Buffo, F. Rossi, A. B. Oestreicher, W. H. Gispen, G. Zamboni, R. Amici, C. A. Jones, E. Perez, R. Domeniconi, P. L. Parmeggiani, Michele Zoli, Nicolas Le Novàre, Jean -Pierre Changeux, C. L. Lafortuna, E. Reinach, F. Saibene, L. Zocchi, E. Agostoni, and D. Cremaschi
Subjects: Physiology, Physiology (medical), Clinical Biochemistry
Published: 1996

4. Trigeminal ganglion neuron subtype-specific alterations of Ca(V)2.1 calcium current and excitability in a Cacna1a mouse model of migraine

Author: B, Fioretti, L, Catacuzzeno, L, Sforna, M B, Gerke-Duncan, A M J M, van den Maagdenberg, F, Franciolini, M, Connor, and D, Pietrobon
Subjects: Male, Neurons, Cerebellar Ataxia, Calcitonin Gene-Related Peptide, Migraine Disorders, Mice, Transgenic, Calcium Channels, P-Type, Calcium Channels, Q-Type, Mice, Inbred C57BL, Disease Models, Animal, Mice, Calcium Channels, N-Type, Trigeminal Ganglion, Mutation, Animals, Female, Capsaicin, Perspectives
Abstract: Familial hemiplegic migraine type-1 (FHM1), a monogenic subtype of migraine with aura, is caused by gain-of-function mutations in Ca(V)2.1 (P/Q-type) calcium channels. The consequences of FHM1 mutations on the trigeminovascular pathway that generates migraine headache remain largely unexplored. Here we studied the calcium currents and excitability properties of two subpopulations of small-diameter trigeminal ganglion (TG) neurons from adult wild-type (WT) and R192Q FHM1 knockin (KI) mice: capsaicin-sensitive neurons without T-type calcium currents (CS) and capsaicin-insensitive neurons characterized by the expression of T-type calcium currents (CI-T). Small TG neurons retrogradely labelled from the dura are mostly CS neurons, while CI-T neurons were not present in the labelled population. CS and CI-T neurons express Ca(V)2.1 channels with different activation properties, and the Ca(V)2.1 channels are differently affected by the FHM1 mutation in the two TG neuron subtypes. In CI-T neurons from FHM1 KI mice there was a larger P/Q-type current density following mild depolarizations, a larger action potential (AP)-evoked calcium current and a longer AP duration when compared to CI-T neurons from WT mice. In striking contrast, the P/Q-type current density, voltage dependence and kinetics were not altered by the FHM1 mutation in CS neurons. The excitability properties of mutant CS neurons were also unaltered. Congruently, the FHM1 mutation did not alter depolarization-evoked CGRP release from the dura mater, while CGRP release from the trigeminal ganglion was larger in KI compared to WT mice. Our findings suggest that the facilitation of peripheral mechanisms of CGRP action, such as dural vasodilatation and nociceptor sensitization at the meninges, does not contribute to the generation of headache in FHM1.
Published: 2011

5. Subdegree Sunyaev-Zel'dovich Signal from Multifrequency BOOMERanG observations

Author: M. VENEZIANI, A. AMBLARD, A. COORAY, F. PIACENTINI, D. PIETROBON, P.SERRA, P. A. R. ADE, J. J. BOCK, J. R. BOND, J. BORRILL, A. BOSCALERI, P.CABELLA, C. R. CONTALDI, B. P. CRILL, DE BERNARDIS P., G. DE GASPERIS, A.DE OLIVEIRA-COSTA, G. DE TROIA, and G. DI STE
Published: 2009

6. Spherical needlets for cosmic microwave background data analysis

Author: Nicola Vittorio, Dominique Picard, Amedeo Balbi, D. Pietrobon, P. Cabella, P. Natoli, Paolo Baldi, Gérard Kerkyacharian, and Domenico Marinucci
Subjects: Statistics::Theory, cosmic microwave background, media_common.quotation_subject, Cosmic microwave background, Mathematics::Classical Analysis and ODEs, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, 01 natural sciences, Wavelet, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, Tangent space, Statistical physics, 010303 astronomy & astrophysics, media_common, Physics, Pixel, 010308 nuclear & particles physics, Angular distance, HEALPix, Astronomy and Astrophysics, methods: data analysis , cosmic microwave background , cosmology: observations, methods: data analysis, Uncorrelated, Space and Planetary Science, Sky, cosmology: observations
Abstract: We discuss Spherical Needlets and their properties. Needlets are a form of spherical wavelets which do not rely on any kind of tangent plane approximation and enjoy good localization properties in both pixel and harmonic space; moreover needlets coefficients are asymptotically uncorrelated at any fixed angular distance, which makes their use in statistical procedures very promising. In view of these properties, we believe needlets may turn out to be especially useful in the analysis of Cosmic Microwave Background (CMB) data on the incomplete sky, as well as of other cosmological observations. As a final advantage, we stress that the implementation of needlets is computationally very convenient and may rely completely on standard data analysis packages such as HEALPix.
Published: 2008

7. Planck intermediate results. XII: Diffuse Galactic components in the Gould Belt system

Author: P.A.R. Ade, N. Aghanim, M.I.R. Alves, M. Arnaud, M. Ashdown, F. Atrio-Barandela, J. Aumont, C. Baccigalupi, A. Balbi, A.J. Banday, R.B. Barreiro, J.G. Bartlett, E. Battaner, L. Bedini, K. Benabed, A. Benoit, J.P. Bernard, M. Bersanelli, A. Bonaldi, J.R. Bond, J. Borrill, F.R. Bouchet, F. Boulanger, C. Burigana, R.C. Butler, P. Cabella, J.F. Cardoso, X. Chen, L.Y. Chiang, P.R. Christensen, D.L. Clements, S. Colombi, L.P.L. Colombo, A. Coulais, F. Cuttaia, R.D. Davies, R.J. Davis, Paolo De Bernardis, G. De Gasperis, G. De Zotti, J. Delabrouille, C. Dickinson, J.M. Diego, G. Dobler, H. Dole, S. Donzelli, O. Dore, M. Douspis, X. Dupac, T.A. Ensslin, F. Finelli, O. Forni, M. Frailis, E. Franceschi, S. Galeotta, K. Ganga, R.T. Genova-Santos, T. Ghosh, M. Giard, G. Giardino, Y. Giraud-Heraud, J. Gonzalez-Nuevo, K.M. Gorski, A. Gregorio, A. Gruppuso, F.K. Hansen, D. Harrison, C. Hernandez-Monteagudo, S.R. Hildebrandt, E. Hivon, M. Hobson, W.A. Holmes, A. Hornstrup, W. Hovest, K.M. Huffenberger, T.R. Jaffe, A.H. Jaffe, M. Juvela, E. Keihanen, R. Keskitalo, T.S. Kisner, J. Knoche, M. Kunz, H. Kurki-Suonio, G. Lagache, A. Lahteenmaki, J.M. Lamarre, A. Lasenby, C.R. Lawrence, S. Leach, R. Leonardi, P.B. Lilje, M. Linden-Vørnle, M. Linden-Vornle, P.M. Lubin, J.F. Macias-Perez, B. Maffei, D. Maino, N. Mandolesi, M. Maris, D.J. Marshall, P.G. Martin, E. Martinez-Gonzalez, Silvia Masi, M. Massardi, S. Matarrese, P. Mazzotta, Alessandro Melchiorri, A. Mennella, S. Mitra, M.A. Miville-Deschenes, A. Moneti, L. Montier, G. Morgante, D. Mortlock, D. Munshi, J.A. Murphy, P. Naselsky, Federico Nati, P. Natoli, H.U. Nørgaard-Nielsen, H.U. Norgaard-Nielsen, F. Noviello, D. Novikov, I. Novikov, S. Osborne, C.A. Oxborrow, F. Pajot, R. Paladini, D. Paoletti, M. Peel, L. Perotto, F. Perrotta, Francesco Piacentini, M. Piat, E. Pierpaoli, D. Pietrobon, S. Plaszczynski, E. Pointecouteau, Gianluca Polenta, L. Popa, T. Poutanen, G.W. Pratt, S. Prunet, J.L. Puget, J.P. Rachen, W.T. Reach, R. Rebolo, M. Reinecke, C. Renault, Sara Ricciardi, I. Ristorcelli, G. Rocha, C. Rosset, J.A. Rubino-Martin, B. Rusholme, E. Salerno, M. Sandri, Giorgio Savini, D. Scott, L. Spencer, V. Stolyarov, R. Sudiwala, A.S. Suur-Uski, J.F. Sygnet, J.A. Tauber, L. Terenzi, C.T. Tibbs, L. Toffolatti, M. Tomasi, M. Tristram, L. Valenziano, B. Van Tent, J. Varis, P. Vielva, F. Villa, N. Vittorio, L.A. Wade, B.D. Wandelt, N. Ysard, D. Yvon, A. Zacchei, A. Zonca, APC - Cosmologie, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Hélium : du fondamental aux applications (HELFA), Institut Néel (NEEL), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), APC - Gravitation (APC-Gravitation), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), PLANCK, Ade, P, Aghanim, N, Alves, M, Arnaud, M, Ashdown, M, Atrio-Barandela, F, Aumont, J, Baccigalupi, C, Balbi, A, Banday, A, Barreiro, R, Bartlett, J, Battaner, E, Bedini, L, Benabed, K, Benoit, A, Bernard, J, Bersanelli, M, Bonaldi, A, Bond, J, Borrill, J, Bouchet, F, Boulanger, F, Burigana, C, Butler, R, Cabella, P, Cardoso, J, Chen, X, Chiang, L, Christensen, P, Clements, D, Colombi, S, Colombo, L, Coulais, A, Cuttaia, F, Davies, R, Davis, R, De Bernardis, P, De Gasperis, G, De Zotti, G, Delabrouille, J, Dickinson, C, Diego, J, Dobler, G, Dole, H, Donzelli, S, Dore, O, Douspis, M, Dupac, X, Ensslin, T, Finelli, F, Forni, O, Frailis, M, Franceschi, E, Galeotta, S, Ganga, K, Genova-Santos, R, Ghosh, T, Giard, M, Giardino, G, Giraud-Heraud, Y, Gonzalez-Nuevo, J, Gorski, K, Gregorio, A, Gruppuso, A, Hansen, F, Harrison, D, Hernandez-Monteagudo, C, Hildebrandt, S, Hivon, E, Hobson, M, Holmes, W, Hornstrup, A, Hovest, W, Huffenberger, K, Jaffe, T, Jaffe, A, Juvela, M, Keihanen, E, Keskitalo, R, Kisner, T, Knoche, J, Kunz, M, Kurki-Suonio, H, Lagache, G, Lahteenmaki, A, Lamarre, J, Lasenby, A, Lawrence, C, Leach, S, Leonardi, R, Lilje, P, Linden-Vørnle, M, Linden-Vornle, M, Lubin, P, Macias-Perez, J, Maffei, B, Maino, D, Mandolesi, N, Maris, M, Marshall, D, Martin, P, Martinez-Gonzalez, E, Masi, S, Massardi, M, Matarrese, S, Mazzotta, P, Melchiorri, A, Mennella, A, Mitra, S, Miville-Deschenes, M, Moneti, A, Montier, L, Morgante, G, Mortlock, D, Munshi, D, Murphy, J, Naselsky, P, Nati, F, Natoli, P, Nørgaard-Nielsen, H, Norgaard-Nielsen, H, Noviello, F, Novikov, D, Novikov, I, Osborne, S, Oxborrow, C, Pajot, F, Paladini, R, Paoletti, D, Peel, M, Perotto, L, Perrotta, F, Piacentini, F, Piat, M, Pierpaoli, E, Pietrobon, D, Plaszczynski, S, Pointecouteau, E, Polenta, G, Popa, L, Poutanen, T, Pratt, G, Prunet, S, Puget, J, Rachen, J, Reach, W, Rebolo, R, Reinecke, M, Renault, C, Ricciardi, S, Ristorcelli, I, Rocha, G, Rosset, C, Rubino-Martin, J, Rusholme, B, Salerno, E, Sandri, M, Savini, G, Scott, D, Spencer, L, Stolyarov, V, Sudiwala, R, Suur-Uski, A, Sygnet, J, Tauber, J, Terenzi, L, Tibbs, C, Toffolatti, L, Tomasi, M, Tristram, M, Valenziano, L, Van Tent, B, Varis, J, Vielva, P, Villa, F, Vittorio, N, Wade, L, Wandelt, B, Ysard, N, Yvon, D, Zacchei, A, Zonca, A, Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Hélium : du fondamental aux applications (NEEL - HELFA), Jodrell Bank Centre for Astrophysics (JBCA), University of Manchester [Manchester], Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPhP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Planck Collaboration, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Département de Physique des Particules (ex SPP) (DPP), P. A. R., Ade, N., Aghanim, M. I. R., Alve, M., Arnaud, M., Ashdown, F., Atrio Barandela, J., Aumont, C., Baccigalupi, A., Balbi, A. J., Banday, R. B., Barreiro, J. G., Bartlett, E., Battaner, L., Bedini, K., Benabed, A., Benoît, J. P., Bernard, M., Bersanelli, A., Bonaldi, J. R., Bond, J., Borrill, F. R., Bouchet, F., Boulanger, C., Burigana, R. C., Butler, P., Cabella, J. F., Cardoso, X., Chen, L. Y., Chiang, P. R., Christensen, D. L., Clement, S., Colombi, L. P. L., Colombo, A., Coulai, F., Cuttaia, R. D., Davie, R. J., Davi, P., de Bernardi, G., de Gasperi, G., de Zotti, J., Delabrouille, C., Dickinson, J. M., Diego, G., Dobler, H., Dole, S., Donzelli, O., Doré, M., Douspi, X., Dupac, T. A., Enßlin, F., Finelli, O., Forni, M., Fraili, E., Franceschi, S., Galeotta, K., Ganga, R. T., Génova Santo, T., Ghosh, M., Giard, G., Giardino, Y., Giraud Héraud, J., González Nuevo, K. M., Górski, Gregorio, Anna, A., Gruppuso, F. K., Hansen, D., Harrison, C., Hernández Monteagudo, S. R., Hildebrandt, E., Hivon, M., Hobson, W. A., Holme, A., Hornstrup, W., Hovest, K. M., Huffenberger, T. R., Jaffe, A. H., Jaffe, M., Juvela, E., Keihänen, R., Keskitalo, T. S., Kisner, J., Knoche, M., Kunz, H., Kurki Suonio, G., Lagache, A., Lähteenmäki, J. M., Lamarre, A., Lasenby, C. R., Lawrence, S., Leach, R., Leonardi, P. B., Lilje, M., Linden Vørnle, P. M., Lubin, J. F., Macías Pérez, B., Maffei, D., Maino, N., Mandolesi, M., Mari, D. J., Marshall, P. G., Martin, E., Martínez González, S., Masi, M., Massardi, S., Matarrese, P., Mazzotta, A., Melchiorri, A., Mennella, S., Mitra, M. A., Miville Deschêne, A., Moneti, L., Montier, G., Morgante, D., Mortlock, D., Munshi, J. A., Murphy, P., Naselsky, F., Nati, P., Natoli, H. U., Nørgaard Nielsen, F., Noviello, D., Novikov, I., Novikov, S., Osborne, C. A., Oxborrow, F., Pajot, R., Paladini, D., Paoletti, M., Peel, L., Perotto, F., Perrotta, F., Piacentini, M., Piat, E., Pierpaoli, D., Pietrobon, S., Plaszczynski, E., Pointecouteau, G., Polenta, L., Popa, T., Poutanen, G. W., Pratt, S., Prunet, J. L., Puget, J. P., Rachen, W. T., Reach, R., Rebolo, M., Reinecke, C., Renault, S., Ricciardi, I., Ristorcelli, G., Rocha, C., Rosset, J. A., Rubiño Martín, B., Rusholme, E., Salerno, M., Sandri, G., Savini, D., Scott, L., Spencer, V., Stolyarov, R., Sudiwala, A. S., Suur Uski, J. F., Sygnet, J. A., Tauber, L., Terenzi, C. T., Tibb, L., Toffolatti, M., Tomasi, M., Tristram, L., Valenziano, B., Van Tent, J., Vari, P., Vielva, F., Villa, N., Vittorio, L. A., Wade, B. D., Wandelt, N., Ysard, D., Yvon, A., Zacchei, A., Zonca, Anne Lähteenmäki Group, Aalto-yliopisto, Aalto University, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Jodrell Bank Centre for Astrophysics, Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, HELFA - Hélium : du fondamental aux applications, Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Department of Physics, and Helsinki Institute of Physics
Subjects: CENTIMETER-WAVE CONTINUUM, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astronomy, Anomalous microwave emission, WMAP OBSERVATIONS, Flux, Astrophysics, Galaxy: general - radio continuum, 01 natural sciences, 7. Clean energy, ANOMALOUS DUST, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Galaxy: general, Radiation mechanisms: general, Radio continuum: ISM, SPINNING DUST EMISSION, 010303 astronomy & astrophysics, general [Radiation mechanisms], Physics, general - radio continuum [Galaxy], Line-of-sight, FOREGROUND EMISSION, general [ISM-radiation mechanism], Component separation, J.2 PHYSICAL SCIENCES AND ENGINEERING. Astronomy, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, symbols, Electron temperature, Correlated component analysis, Galaxy: general – radio continuum: ISM – radiation mechanis ms: general, Astrophysics - Cosmology and Nongalactic Astrophysics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), H-ALPHA, INFRARED-EMISSION, Astrophysics::High Energy Astrophysical Phenomena, education, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, Component analysis, Position (vector), 0103 physical sciences, Thermal, PRE-LAUNCH STATUS, radio continuum: ISM, radiation mechanisms: general, Planck, general – radio continuum: ISM – radiation mechanis ms: general [Galaxy], general [Galaxy], Astrophysics::Galaxy Astrophysics, radio continuum: ism, galaxy: general, 010308 nuclear & particles physics, Astronomy and Astrophysics, 115 Astronomy, Space science, MICROWAVE-ANISOTROPY-PROBE, Astrophysics - Astrophysics of Galaxies, ISM [Radio continuum], Frequency spectrum, 13. Climate action, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), TENTATIVE DETECTION, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], ISM-radiation mechanism: general
Abstract: We perform an analysis of the diffuse low-frequency Galactic components in the southern part of the Gould Belt system (130◦ ≤ l ≤ 230◦ and −50◦ ≤ b ≤ −10◦). Strong ultra-violet flux coming from the Gould Belt super-association is responsible for bright diffuse foregrounds that we observe from our position inside the system and that can help us improve our knowledge of the Galactic emission. Free-free emission and anomalous microwave emission (AME) are the dominant components at low frequencies (ν < 40 GHz), while synchrotron emission is very smooth and faint. We separated diffuse free-free emission and AME from synchrotron emission and thermal dust emission by using Planck data, complemented by ancillary data, using the correlated component analysis (CCA) component-separation method and we compared our results with the results of cross-correlation of foreground templates with the frequency maps. We estimated the electron temperature Te from Hα and free-free emission using two methods (temperature-temperature plot and cross-correlation) and obtained Te ranging from 3100 to 5200 K for an effective fraction of absorbing dust along the line of sight of 30% ( fd = 0.3). We estimated the frequency spectrum of the diffuse AME and recovered a peak frequency (in flux density units) of 25.5±1.5 GHz.We verified the reliability of this result with realistic simulations that include biases in the spectral model for the AME and in the free-free template. By combining physical models for vibrational and rotational dust emission and adding the constraints from the thermal dust spectrum from Planck and IRAS, we are able to present a good description of the AME frequency spectrum for plausible values of the local density and radiation field., The development of Planck has been supported by: ESA; CNES and CNRS/INSU-IN2P3-INP (France); ASI, CNR, and INAF (Italy); NASA and DoE (USA); STFC and UKSA (UK); CSIC, MICINN and JA (Spain); Tekes, AoF and CSC (Finland); DLR and MPG (Germany); CSA (Canada); DTU Space (Denmark); SER/SSO (Switzerland); RCN (Norway); SFI (Ireland); FCT/MCTES (Portugal); and PRACE (EU).
Published: 2013

8. 2 NEURONAL CALCIUM CHANNELS AND MIGRAINE

Author: D. Pietrobon
Subjects: Anesthesiology and Pain Medicine, Migraine, Voltage-dependent calcium channel, business.industry, Cortical spreading depression, medicine, medicine.disease, business, Neuroscience
Published: 2011

9. EFFECT OF LOW-DENSITY LIPOPROTEINS, MEVINOLIN, AND G-PROTEINS ON CA2+ RESPONSE IN CULTURED CHICK ATRIAL CELLS

Author: Jonas B. Galper, C. Greiser, D. Pietrobon, Joey V. Barnett, James D. Marsh, Wen Tan, and G. Hehn
Subjects: Agonist, Dihydropyridines, medicine.medical_specialty, Contraction (grammar), Physiology, G protein, medicine.drug_class, chemistry.chemical_element, Chick Embryo, Calcium, Biology, Pertussis toxin, chemistry.chemical_compound, GTP-Binding Proteins, Physiology (medical), Internal medicine, medicine, Animals, Heart Atria, Lovastatin, Virulence Factors, Bordetella, Cells, Cultured, Cell growth, Cholesterol, Myocardium, 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester, Fetal Blood, Adenosine, Lipoproteins, LDL, Endocrinology, Pertussis Toxin, chemistry, Cattle, Calcium Channels, Extracellular Space, Cardiology and Cardiovascular Medicine, medicine.drug
Abstract: Growth of cells from atria of embryonic chick hearts 14 days in ovo in medium supplemented with lipoprotein-depleted serum (LPDS) results in an increase in total cell cholesterol, enhanced parasympathetic responsiveness (7), and decreased sympathetic responsiveness (1). These effects were reversed by the hydroxymethyl glutaryl CoA reductase inhibitor, mevinolin. In these studies, comparison of cell growth in medium supplemented with fetal calf serum (FCS) and LPDS demonstrated that, after growth with LPDS, the ability of Ca2+ and the Ca2+ channel agonist, BAY K 8644, to enhance the amplitude of contraction decreased by 25 and 50%, respectively. These effects of growth in LPDS were reversed by incubation with mevinolin. LPDS had no effect on either Ca2+ channel number as measured by (+)-[5-methyl-3H]PN200-110 binding or Ca2+ current density as measured by the whole cell patch method. Treatment of cells grown in LPDS with pertussis toxin, which inactivates alpha o and alpha i, returned the contractile response to 10(-7) M BAY K 8644 to control levels. Pertussis toxin had no effect on the contractile response or adenosine 3',5'-cyclic monophosphate levels in control cells grown in FCS alone. These data suggest that alterations in the relative levels of alpha o and alpha s in cells grown in LPDS may play a role in regulating the contractile response to Ca2+ channel agonists and to exogenous Ca2+.
Published: 1993

10. Double-inhibitor and uncoupler-inhibitor-titrations. 2. Analysis with a nonlinear model of chemiosmotic energy coupling

Author: D, Pietrobon and S R, Caplan
Subjects: Adenosine Triphosphatases, Kinetics, Hydrogen-Ion Concentration, Energy Metabolism, Models, Biological, Biochemistry, Mathematics
Abstract: The results of double-inhibitor and uncoupler-inhibitor titrations have been simulated and analyzed with a nonlinear model of delocalized protonic coupling obtained by linking two proton pump models of the kind studied by Pietrobon and Caplan [Pietrobon, D.,Caplan, S. R. (1985) Biochemistry 24, 5764-5776] through their common intermediate delta mu H. It is shown that the results predicted by a delocalized chemiosmotic model are highly dependent on the kind of relationships existing between rate of ATP synthesis, Jp, and delta mu H and rate of electron transfer, Je, and delta mu H. With nonlinear flow-force relationships all the results reported so far are not necessarily inconsistent with the delocalized chemiosmotic model provided that the relationships between rates and delta mu H satisfy the following requirements: Jp/delta mu H increases and/or Je/delta mu H decreases as (delta mu H) increases.
Published: 1986

11. Single and Double Inhibitor Titrations of Bacterial Photophosphorylation

Author: B. A. Melandri, Giovanni Venturoli, Marco Virgili, and D. Pietrobon
Subjects: Quantitative Biology::Subcellular Processes, Membrane potential, Delocalized electron, Membrane, ATP synthase, biology, Chemiosmosis, Chemistry, Biophysics, biology.protein, Photophosphorylation, Electron transport chain, Proton pump
Abstract: In the minimal scheme of chemiosmotic coupling the primary and secondary proton pumps are coupled through a delocalized pool of common intermediates, the high-energy protons located at one side of the coupling membrane. This mechanism is therefore only consistent with a fully delocalized interaction of the primary and secondary proton pumps, since the model assumes complete electrochemical equilibrium for protons in the bulk phases at both sides of the membranes, and also complete protonic equilibrium with the protolytic sites of both types of pump. Titration of the rate of phosphorylation with inhibitors of the ATP synthetase and of the electron transfer chain, or with uncouplers, are traditionally important tools for the study of the mechanism of energy transduction and for establishing its degree of derealization. Indeed, using this experimental approach results have been obtained which have been interpreted as non consistent with a fully delocalized coupling mechanism. These data indicated the absence of a univocal correlation in the flow-force relationship for the ATP synthetase, when the system was perturbed with different agents. These results relied heavily on the accuracy in the quantitative estimation of the transmembrane potential and pH difference (1,2).
Published: 1987

12. Uncoupling of oxidative phosphorylation induced by FCCP oleic acid and chloroform in rat liver mitochondria

Author: S, Luvisetto, D, Pietrobon, and G F, Azzone
Subjects: Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone, Kinetics, Oxygen Consumption, Uncoupling Agents, Nitriles, Animals, Antimycin A, Mitochondria, Liver, Oleic Acids, Chloroform, Oxidative Phosphorylation, Rats
Published: 1988

13. Use of nonequilibrium thermodynamics in the analysis of transport: general flow-force relationships and the linear domain

Author: D, Pietrobon and S R, Caplan
Subjects: Kinetics, Membranes, Animals, Thermodynamics, Biological Transport, Models, Theoretical, Mathematics
Published: 1989

14. The molecular slipping in the redox-driven H+ pumps

Author: G F, Azzone, D, Pietrobon, and D, Walz
Subjects: Electron Transport, Kinetics, Oxygen Consumption, Animals, Mitochondria, Liver, Hydrogen-Ion Concentration, Oxidation-Reduction, Mathematics, Mitochondria, Rats
Published: 1982

15. Planck 2015 results. II. Low Frequency Instrument data processing

Author: E. Martínez-González, F. Couchot, Hannu Kurki-Suonio, M. Piat, T. Riller, P. A. R. Ade, W. A. Holmes, B. Racine, S. Mottet, Peregrine McGehee, J.-F. Sygnet, F. Cuttaia, D. L. Clements, N. Ponthieu, L. Sanselme, J. J. Bock, X. Dupac, A. Curto, Simon Prunet, Jérôme Bobin, A. Chamballu, R. Kneissl, R. Keskitalo, Steven Gratton, K. Ganga, P. Bielewicz, G. Rocha, William T. Reach, O. Doré, J.-L. Puget, D. L. Harrison, Jean-François Cardoso, L. Perotto, Jose M. Diego, Lloyd Knox, E. P. S. Shellard, R. Paladini, O. Herent, W. Hovest, E. Pointecouteau, P. B. Lilje, R. J. Laureijs, J. A. Tauber, R. B. Barreiro, Michele Liguori, J. Borrill, A. Benoit-Lévy, Fernando Atrio-Barandela, K. M. Górski, M. Tristram, J. Delabrouille, F. Piacentini, L. Vibert, M. Giard, F. Noviello, D. Hanson, Aurelien A. Fraisse, R. J. Davis, G. Hurier, A. Gregorio, George Helou, François R. Bouchet, Calvin B. Netterfield, B. P. Crill, Charles R. Lawrence, G. Patanchon, J. F. Macías-Pérez, G. Roudier, Fabio Finelli, D. Pietrobon, Carol Anne Oxborrow, A. Zonca, D. Yvon, Bruno Maffei, F. Paci, Lung-Yih Chiang, Silvia Masi, S. D. M. White, F. Pajot, R. D. Davies, M. Le Jeune, A. de Rosa, H. C. Chiang, Sophie Henrot-Versille, L. P. L. Colombo, Michael P. Hobson, Peter Meinhold, K. Benabed, F. Perrotta, Dmitry Novikov, M. Frailis, Daniele Tavagnacco, Carlo Baccigalupi, F.-X. Désert, Alessandro Melchiorri, Julien Lesgourgues, Mika Juvela, E. Hivon, Xin Chen, J. R. Bond, Dipak Munshi, François Orieux, George Efstathiou, J.-M. Lamarre, Alessandro Gruppuso, Nicola Vittorio, M. Arnaud, J. González-Nuevo, A. Zacchei, T. Poutanen, C. Armitage-Caplan, G. W. Pratt, B. Rusholme, Michael Rowan-Robinson, Andrew H. Jaffe, Fabio Pasian, F. Villa, J.-P. Bernard, Gianluca Morgante, G. Umana, Sabino Matarrese, Marc-Antoine Miville-Deschenes, L. Montier, Locke D. Spencer, Philip Lubin, A. Moneti, Luca Valenziano, S. Mitra, J. Knoche, Allan Hornstrup, Michele Maris, Federico Nati, Z. Hou, Torsten A. Enßlin, M. Ashdown, Anthony Lasenby, H. K. Eriksen, M. Tomasi, D. Paoletti, G. Lagache, S. Osborne, R. V. Sudiwala, E. Keihänen, Jean-Luc Starck, S. R. Hildebrandt, D. J. Marshall, Luca Terenzi, C. Combet, V. Stolyarov, C. J. MacTavish, P. R. Christensen, Marco Bersanelli, B. D. Wandelt, Rafael Rebolo, A. Coulais, T. R. Jaffe, D. Herranz, M. Kunz, P. Natoli, Martin Reinecke, E. Battaner, Carlo Burigana, L. Mendes, Pavel D. Naselsky, F. Boulanger, L. Danese, P. de Bernardis, Stéphane Plaszczynski, Mathieu Remazeilles, I. Ristorcelli, G. de Zotti, Giovanna Giardino, Clive Dickinson, M. Douspis, D. Sutton, J. Aumont, J. Valiviita, C. North, A. Sauvé, Aurélien Benoit, Lawrence A. Wade, S. Ricciardi, B. Van Tent, A. J. Banday, F. Sureau, Nazzareno Mandolesi, J.-M. Delouis, C. Rosset, Jon E. Gudmundsson, L. Pagano, Hans Ulrik Nørgaard-Nielsen, R. Stompor, D. Girard, F. Matthai, Jörg P. Rachen, C. Renault, A.-S. Suur-Uski, D. Santos, M. Bucher, M. Migliaccio, R. Leonardi, Olivier Forni, F. K. Hansen, M. Tucci, Stéphane Colombi, M. Bridges, E. Franceschi, P. Vielva, S. Galeotta, Pierrick Martin, Elena Pierpaoli, Y. Giraud-Héraud, Pasquale Mazzotta, H. Dole, Theodore Kisner, Claude Leroy, I. D. Novikov, G. Prézeau, M. López-Caniego, R.-R. Chary, L. Popa, Daniel J. Mortlock, C. Hernández-Monteagudo, Kevin M. Huffenberger, Jo Dunkley, G. Polenta, M. Linden-Vørnle, Sarah E. Church, J. W. Bowyer, W. C. Jones, A. Mennella, Nabila Aghanim, O. Perdereau, S. Donzelli, Giorgio Savini, A. Catalano, S. Techene, Ade, P. A. R., Aghanim, N., Ashdown, M., Aumont, J., Baccigalupi, C., Ballardini, M., Banday, A. J., Barreiro, R. B., Bartolo, N., Basak, S., Battaglia, PAOLA MARIA, Battaner, E., Benabed, K., Benoît, A., Benoit Lévy, A., Bernard, J. P., Bersanelli, M., Bielewicz, P., Bock, J. J., Bonaldi, A., Bonavera, L., Bond, J. R., Borrill, J., Bouchet, F. R., Bucher, M., Burigana, C., Butler, R. C., Calabrese, E., Cardoso, J. F., Castex, G., Catalano, A., Chamballu, A., Christensen, P. R., Colombi, S., Colombo, L. P. L., Crill, B. P., Curto, A., Cuttaia, F., Danese, L., Davies, R. D., Davis, R. J., De Bernardis, P., De Rosa, A., De Zotti, G., Delabrouille, J., Dickinson, C., Diego, J. M., Dole, H., Donzelli, Simona, Doré, O., Douspis, M., Ducout, A., Dupac, X., Efstathiou, G., Elsner, F., Enßlin, T. A., Eriksen, H. K., Fergusson, J., Finelli, F., Forni, O., Frailis, M., Franceschet, C., Franceschi, E., Frejsel, A., Galeotta, S., Galli, S., Ganga, K., Giard, M., Giraud Héraud, Y., Gjerløw, E., González Nuevo, J., Górski, K. M., Gratton, S., Gregorio, Anna, Gruppuso, A., Hansen, F. K., Hanson, D., Harrison, D. L., Henrot Versillé, S., Herranz, D., Hildebrandt, S. R., Hivon, E., Hobson, M., Holmes, W. A., Hornstrup, A., Hovest, W., Huffenberger, K. M., Hurier, G., Jaffe, A. H., Jaffe, T. R., Juvela, M., Keihänen, E., Keskitalo, R., Kiiveri, K., Kisner, T. S., Knoche, J., Krachmalnicoff, N., Kunz, M., Kurki Suonio, H., Lagache, G., Lähteenmäki, A., Lamarre, J. M., Lasenby, A., Lattanzi, M., Lawrence, C. R., Leahy, J. P., Leonardi, R., Lesgourgues, J., Levrier, F., Liguori, M., Lilje, P. B., Linden Vørnle, M., Lindholm, V., López Caniego, M., Lubin, P. M., Macías Pérez, J. F., Maggio, G., Maino, D., Mandolesi, N., Mangilli, A., Maris, M., Martin, P. G., Martínez González, E., Masi, S., Matarrese, S., Mazzotta, P., Mcgehee, P., Meinhold, P. R., Melchiorri, A., Mendes, L., Mennella, A., Migliaccio, M., Mitra, S., Montier, L., Morgante, G., Morisset, N., Mortlock, D., Moss, A., Munshi, D., Murphy, J. A., Naselsky, P., Nati, F., Natoli, P., Netterfield, C. B., Nørgaard Nielsen, H. U., Novikov, D., Novikov, I., Oppermann, N., Paci, F., Pagano, L., Paoletti, D., Partridge, B., Pasian, F., Patanchon, G., Pearson, T. J., Peel, M., Perdereau, O., Perotto, L., Perrotta, F., Pettorino, V., Piacentini, F., Pierpaoli, E., Pietrobon, D., Pointecouteau, E., Polenta, G., Pratt, G. W., Prézeau, G., Prunet, S., Puget, J. L., Rachen, J. P., Rebolo, R., Reinecke, M., Remazeilles, M., Renzi, A., Rocha, G., Romelli, Erik, Rosset, C., Rossetti, M., Roudier, G., Rubiño Martín, J. A., Rusholme, B., Sandri, M., Santos, D., Savelainen, M., Scott, D., Seiffert, M. D., Shellard, E. P. S., Spencer, L. D., Stolyarov, V., Sutton, D., Suur Uski, A. S., Sygnet, J. F., Tauber, J. A., Tavagnacco, Daniele, Terenzi, L., Toffolatti, L., Tomasi, M., Tristram, M., Tucci, M., Tuovinen, J., Türler, M., Umana, G., Valenziano, L., Valiviita, J., Van Tent, B., Vassallo, T., Vielva, P., Villa, F., Wade, L. A., Wandelt, B. D., Watson, R., Wehus, I. K., Wilkinson, A., Yvon, D., Zacchei, A, Zonca, A., Ade, P, Aghanim, N, Ashdown, M, Aumont, J, Baccigalupi, C, Ballardini, M, Banday, A, Barreiro, R, Bartolo, N, Basak, S, Battaglia, P, Battaner, E, Benabed, K, Benoît, A, Benoit Lévy, A, Bernard, J, Bersanelli, M, Bielewicz, P, Bock, J, Bonaldi, A, Bonavera, L, Bond, J, Borrill, J, Bouchet, F, Bucher, M, Burigana, C, Butler, R, Calabrese, E, Cardoso, J, Castex, G, Catalano, A, Chamballu, A, Christensen, P, Colombi, S, Colombo, L, Crill, B, Curto, A, Cuttaia, F, Danese, L, Davies, R, Davis, R, DE BERNARDIS, P, De Rosa, A, De Zotti, G, Delabrouille, J, Dickinson, C, Diego, J, Dole, H, Donzelli, S, Doré, O, Douspis, M, Ducout, A, Dupac, X, Efstathiou, G, Elsner, F, Enßlin, T, Eriksen, H, Fergusson, J, Finelli, F, Forni, O, Frailis, M, Franceschet, C, Franceschi, E, Frejsel, A, Galeotta, S, Galli, S, Ganga, K, Giard, M, Giraud Héraud, Y, Gjerløw, E, González Nuevo, J, Górski, K, Gratton, S, Gregorio, A, Gruppuso, A, Hansen, F, Hanson, D, Harrison, D, Henrot Versillé, S, Herranz, D, Hildebrandt, S, Hivon, E, Hobson, M, Holmes, W, Hornstrup, A, Hovest, W, Huffenberger, K, Hurier, G, Jaffe, A, Jaffe, T, Juvela, M, Keihänen, E, Keskitalo, R, Kiiveri, K, Kisner, T, Knoche, J, Krachmalnicoff, N, Kunz, M, Kurki Suonio, H, Lagache, G, Lähteenmäki, A, Lamarre, J, Lasenby, A, Lattanzi, M, Lawrence, C, Leahy, J, Leonardi, R, Lesgourgues, J, Levrier, F, Liguori, M, Lilje, P, Linden Vørnle, M, Lindholm, V, López Caniego, M, Lubin, P, Macías Pérez, J, Maggio, G, Maino, D, Mandolesi, N, Mangilli, A, Maris, M, Martin, P, Martínez González, E, Masi, S, Matarrese, S, Mazzotta, P, Mcgehee, P, Meinhold, P, Melchiorri, A, Mendes, L, Mennella, A, Migliaccio, M, Mitra, S, Montier, L, Morgante, G, Morisset, N, Mortlock, D, Moss, A, Munshi, D, Murphy, J, Naselsky, P, Nati, F, Natoli, P, Netterfield, C, Nørgaard Nielsen, H, Novikov, D, Novikov, I, Oppermann, N, Paci, F, Pagano, L, Paoletti, D, Partridge, B, Pasian, F, Patanchon, G, Pearson, T, Peel, M, Perdereau, O, Perotto, L, Perrotta, F, Pettorino, V, Piacentini, F, Pierpaoli, E, Pietrobon, D, Pointecouteau, E, Polenta, G, Pratt, G, Prézeau, G, Prunet, S, Puget, J, Rachen, J, Rebolo, R, Reinecke, M, Remazeilles, M, Renzi, A, Rocha, G, Romelli, E, Rosset, C, Rossetti, M, Roudier, G, Rubiño Martín, J, Rusholme, B, Sandri, M, Santos, D, Savelainen, M, Scott, D, Seiffert, M, Shellard, E, Spencer, L, Stolyarov, V, Sutton, D, Suur Uski, A, Sygnet, J, Tauber, J, Tavagnacco, D, Terenzi, L, Toffolatti, L, Tomasi, M, Tristram, M, Tucci, M, Tuovinen, J, Türler, M, Umana, G, Valenziano, L, Valiviita, J, Van Tent, B, Vassallo, T, Vielva, P, Villa, F, Wade, L, Wandelt, B, Watson, R, Wehus, I, Wilkinson, A, Yvon, D, Zonca, A, Hélium : du fondamental aux applications (HELFA), Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Planck, Hélium : du fondamental aux applications (NEEL - HELFA), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), and Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Space vehicles: instruments – Methods:data analysis – cosmic microwave background, [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Cosmology and Nongalactic Astrophysics (astro-ph.CO), [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astronomy, Cosmic microwave background, FOS: Physical sciences, Space vehicles: instrument, Cosmic background radiation, 01 natural sciences, NO, instruments [Space vehicles], Optics, Settore FIS/05 - Astronomia e Astrofisica, Methods: data analysis, 0103 physical sciences, instrument [Space vehicles], Calibration, Space vehicles: instruments, Astronomy and Astrophysics, Space and Planetary Science, Angular resolution, data analysis [Methods], 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), QC, QB, Physics, 010308 nuclear & particles physics, business.industry, Instrument Data, Detector, Spectral density, Ranging, Astronomy and Astrophysic, data analysi [Methods], business, Astrophysics - Instrumentation and Methods for Astrophysics, Noise (radio), Methods: data analysi, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: CSIC, Consejo Superior de Investigaciones Científicas; ERC, European Research Council; MINECO, Ministerio de Economía y Competitividad; MPG, Max-Planck-Gesellschaft; NASA, National Aeronautics and Space Administration; etc., Ade, P.A.R., Aghanim, N., Ashdown, M., Aumont, J., Baccigalupi, C., Ballardini, M., Banday, A.J., Barreiro, R.B., Bartolo, N., Basak, S., Battaglia, P., Battaner, E., Benabed, K., Benoît, A., Benoit-Lévy, A., Bernard, J.-P., Bersanelli, M., Bielewicz, P., Bock, J.J., Bonaldi, A., Bonavera, L., Bond, J.R., Borrill, J., Bouchet, F.R., Bucher, M., Burigana, C., Butler, R.C., Calabrese, E., Cardoso, J.-F., Castex, G., Catalano, A., Chamballu, A., Christensen, P.R., Colombi, S., Colombo, L.P.L., Crill, B.P., Curto, A., Cuttaia, F., Danese, L., Davies, R.D., Davis, R.J., De Bernardis, P., De Rosa, A., De Zotti, G., Delabrouille, J., Dickinson, C., Diego, J.M., Dole, H., Donzelli, S., Doré, O., Douspis, M., Ducout, A., Dupac, X., Efstathiou, G., Elsner, F., Enßlin, T.A., Eriksen, H.K., Fergusson, J., Finelli, F., Forni, O., Frailis, M., Franceschet, C., Franceschi, E., Frejsel, A., Galeotta, S., Galli, S., Ganga, K., Giard, M., Giraud-Héraud, Y., Gjerløw, E., González-Nuevo, J., Górski, K.M., Gratton, S., Gregorio, A., Gruppuso, A., Hansen, F.K., Hanson, D., Harrison, D.L., Henrot-Versillé, S., Herranz, D., Hildebrandt, S.R., Hivon, E., Hobson, M., Holmes, W.A., Hornstrup, A., Hovest, W., Huffenberger, K.M., Hurier, G., Jaffe, A.H., Jaffe, T.R., Juvela, M., Keihänen, E., Keskitalo, R., Kiiveri, K., Kisner, T.S., Knoche, J., Krachmalnicoff, N., Kunz, M., Kurki-Suonio, H., Lagache, G., Lähteenmäki, A., Lamarre, J.-M., Lasenby, A., Lattanzi, M., Lawrence, C.R., Leahy, J.P., Leonardi, R., Lesgourgues, J., Levrier, F., Liguori, M., Lilje, P.B., Linden-Vørnle, M., Lindholm, V., López-Caniego, M., Lubin, P.M., Macías-Pérez, J.F., Maggio, G., Maino, D., Mandolesi, N., Mangilli, A., Maris, M., Martin, P.G., Martínez-González, E., Masi, S., Matarrese, S., Mazzotta, P., McGehee, P., Meinhold, P.R., Melchiorri, A., Mendes, L., Mennella, A., Migliaccio, M., Mitra, S., Montier, L., Morgante, G., Morisset, N., Mortlock, D., Moss, A., Munshi, D., Murphy, J.A., Naselsky, P., Nati, F., Natoli, P., Netterfield, C.B., Nørgaard-Nielsen, H.U., Novikov, D., Novikov, I., Oppermann, N., Paci, F., Pagano, L., Paoletti, D., Partridge, B., Pasian, F., Patanchon, G., Pearson, T.J., Peel, M., Perdereau, O., Perotto, L., Perrotta, F., Pettorino, V., Piacentini, F., Pierpaoli, E., Pietrobon, D., Pointecouteau, E., Polenta, G., Pratt, G.W., Prézeau, G., Prunet, S., Puget, J.-L., Rachen, J.P., Rebolo, R., Reinecke, M., Remazeilles, M., Renzi, A., Rocha, G., Romelli, E., Rosset, C., Rossetti, M., Roudier, G., Rubiño-Martín, J.A., Rusholme, B., Sandri, M., Santos, D., Savelainen, M., Scott, D., Seiffert, M.D., Shellard, E.P.S., Spencer, L.D., Stolyarov, V., Sutton, D., Suur-Uski, A.-S., Sygnet, J.-F., Tauber, J.A., Tavagnacco, D., Terenzi, L., Toffolatti, L., Tomasi, M., Tristram, M., Tucci, M., Tuovinen, J., Türler, M., Umana, G., Valenziano, L., Valiviita, J., Van Tent, B., Vassallo, T., Vielva, P., Villa, F., Wade, L.A., Wandelt, B.D., Watson, R., Wehus, I.K., Wilkinson, A., Yvon, D., Zacchei, A., Zonca, A.

16. Young Researcher Meeting, L'Aquila 2015.

Author: F Agostini, C Antolini, M Bossa, G Cattani, S Dell'Oro, M D'Angelo, M Di Stefano, G Fragione, M Migliaccio, L Pagnanini, D Pietrobon, E Pusceddu, M Serra, and F Stellato
Published: 2016
Full Text: View/download PDF

17. Planck intermediate results. XVII. Emission of dust in the diffuse interstellar medium from the far-infrared to microwave frequencies

Author: Planck Collaboration, Abergel, A., Ade, P. A. R., Aghanim, N., Alves, M. I. R., Aniano, G., Arnaud, M., Ashdown, M., Aumont, J., Baccigalupi, C., Banday, A. J., Barreiro, R. B., Bartlett, J. G., Battaner, E., Benabed, K., Benoit-L��vy, A., Bernard, J. -P., Bersanelli, M., Bielewicz, P., Bobin, J., Bonaldi, A., Bond, J. R., Bouchet, F. R., Boulanger, F., Burigana, C., Cardoso, J. -F., Catalano, A., Chamballu, A., Chiang, H. C., Christensen, P. R., Clements, D. L., Colombi, S., Colombo, L. P. L., Couchot, F., Crill, B. P., Cuttaia, F., Danese, L., Davies, R. D., Davis, R. J., de Bernardis, P., de Rosa, A., de Zotti, G., Delabrouille, J., D��sert, F. -X., Dickinson, C., Diego, J. M., Dole, H., Donzelli, S., Dor��, O., Douspis, M., Dupac, X., Efstathiou, G., En��lin, T. A., Eriksen, H. K., Falgarone, E., Finelli, F., Forni, O., Frailis, M., Franceschi, E., Galeotta, S., Ganga, K., Ghosh, T., Giard, M., Giraud-H��raud, Y., Gonz��lez-Nuevo, J., G��rski, K. M., Gregorio, A., Gruppuso, A., Guillet, V., Hansen, F. K., Harrison, D. L., Helou, G., Henrot-Versill��, S., Hern��ndez-Monteagudo, C., Herranz, D., Hildebrandt, S. R., Hivon, E., Hobson, M., Holmes, W. A., Hornstrup, A., Hovest, W., Huffenberger, K. M., Jaffe, A. H., Jaffe, T. R., Joncas, G., Jones, A., Jones, W. C., Juvela, M., Kalberla, P., Keih��nen, E., Kerp, J., Keskitalo, R., Kisner, T. S., Kneissl, R., Knoche, J., Kunz, M., Kurki-Suonio, H., Lagache, G., L��hteenm��ki, A., Lamarre, J. -M., Lasenby, A., Lawrence, C. R., Leonardi, R., Levrier, F., Liguori, M., Lilje, P. B., Linden-V��rnle, M., L��pez-Caniego, M., Lubin, P. M., Mac��as-P��rez, J. F., Maffei, B., Maino, D., Mandolesi, N., Maris, M., Marshall, D. J., Martin, P. G., Mart��nez-Gonz��lez, E., Masi, S., Massardi, M., Matarrese, S., Mazzotta, P., Melchiorri, A., Mendes, L., Mennella, A., Migliaccio, M., Mitra, S., Miville-Desch��nes, M. -A., Moneti, A., Montier, L., Morgante, G., Mortlock, D., Munshi, D., Murphy, J. A., Naselsky, P., Nati, F., Natoli, P., Noviello, F., Novikov, D., Novikov, I., Oxborrow, C. A., Pagano, L., Pajot, F., Paoletti, D., Pasian, F., Perdereau, O., Perotto, L., Perrotta, F., Piacentini, F., Piat, M., Pierpaoli, E., Pietrobon, D., Plaszczynski, S., Pointecouteau, E., Polenta, G., Ponthieu, N., Popa, L., Pratt, G. W., Prunet, S., Puget, J. -L., Rachen, J. P., Reach, W. T., Rebolo, R., Reinecke, M., Remazeilles, M., Renault, C., Ricciardi, S., Riller, T., Ristorcelli, I., Rocha, G., Rosset, C., Roudier, G., Rusholme, B., Sandri, M., Savini, G., Spencer, L. D., Starck, J. -L., Sureau, F., Sutton, D., Suur-Uski, A. -S., Sygnet, J. -F., Tauber, J. A., Terenzi, L., Toffolatti, L., Tomasi, M., Tristram, M., Tucci, M., Umana, G., Valenziano, L., Valiviita, J., Van Tent, B., Verstraete, L., Vielva, P., Villa, F., Wade, L. A., Wandelt, B. D., Winkel, B., Yvon, D., Zacchei, A., Zonca, A., Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut d'Astrophysique de Paris (IAP), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), PLANCK, Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS-PSL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), European Commission, A., Abergel, P. A. R., Ade, N., Aghanim, M. I. R., Alve, G., Aniano, M., Arnaud, M., Ashdown, J., Aumont, C., Baccigalupi, A. J., Banday, R. B., Barreiro, J. G., Bartlett, E., Battaner, K., Benabed, A., Benoit Lévy, J. P., Bernard, M., Bersanelli, P., Bielewicz, J., Bobin, A., Bonaldi, J. R., Bond, F. R., Bouchet, F., Boulanger, C., Burigana, J. F., Cardoso, A., Catalano, A., Chamballu, H. C., Chiang, P. R., Christensen, D. L., Clement, S., Colombi, L. P. L., Colombo, F., Couchot, B. P., Crill, F., Cuttaia, L., Danese, R. J., Davi, P., de Bernardi, A., de Rosa, G., de Zotti, J., Delabrouille, F. X., Désert, C., Dickinson, J. M., Diego, H., Dole, S., Donzelli, O., Doré, M., Douspi, X., Dupac, G., Efstathiou, T. A., Enßlin, H. K., Eriksen, E., Falgarone, F., Finelli, O., Forni, M., Fraili, E., Franceschi, S., Galeotta, K., Ganga, T., Ghosh, M., Giard, Y., Giraud Héraud, J., González Nuevo, K. M., Górski, Gregorio, Anna, A., Gruppuso, V., Guillet, F. K., Hansen, D., Harrison, G., Helou, S., Henrot Versillé, C., Hernández Monteagudo, D., Herranz, S. R., Hildebrandt, E., Hivon, M., Hobson, W. A., Holme, A., Hornstrup, W., Hovest, K. M., Huffenberger, A. H., Jaffe, T. R., Jaffe, G., Jonca, A., Jone, W. C., Jone, M., Juvela, P., Kalberla, E., Keihänen, J., Kerp, R., Keskitalo, T. S., Kisner, R., Kneissl, J., Knoche, M., Kunz, H., Kurki Suonio, G., Lagache, A., Lähteenmäki, J. M., Lamarre, A., Lasenby, C. R., Lawrence, R., Leonardi, F., Levrier, M., Liguori, P. B., Lilje, M., Linden Vørnle, M., López Caniego, P. M., Lubin, J. F., Macías Pérez, B., Maffei, D., Maino, N., Mandolesi, M., Mari, D. J., Marshall, P. G., Martin, E., Martínez González, S., Masi, M., Massardi, S., Matarrese, P., Mazzotta, A., Melchiorri, L., Mende, A., Mennella, M., Migliaccio, S., Mitra, M. A., Miville Deschêne, A., Moneti, L., Montier, G., Morgante, D., Mortlock, D., Munshi, J. A., Murphy, P., Naselsky, F., Nati, P., Natoli, F., Noviello, D., Novikov, I., Novikov, C. A., Oxborrow, L., Pagano, F., Pajot, D., Paoletti, F., Pasian, O., Perdereau, L., Perotto, F., Perrotta, F., Piacentini, M., Piat, E., Pierpaoli, D., Pietrobon, S., Plaszczynski, E., Pointecouteau, G., Polenta, N., Ponthieu, L., Popa, G. W., Pratt, S., Prunet, J. L., Puget, J. P., Rachen, W. T., Reach, R., Rebolo, M., Reinecke, M., Remazeille, C., Renault, S., Ricciardi, T., Riller, I., Ristorcelli, G., Rocha, C., Rosset, G., Roudier, B., Rusholme, M., Sandri, G., Savini, L. D., Spencer, J. L., Starck, F., Sureau, D., Sutton, A. S., Suur Uski, J. F., Sygnet, J. A., Tauber, L., Terenzi, L., Toffolatti, M., Tomasi, M., Tristram, M., Tucci, G., Umana, L., Valenziano, J., Valiviita, B., Van Tent, L., Verstraete, P., Vielva, F., Villa, L. A., Wade, B. D., Wandelt, B., Winkel, D., Yvon, A., Zacchei, A., Zonca, Department of Physics, Helsinki Institute of Physics, APC - Cosmologie, Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), APC - Gravitation (APC-Gravitation), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Abergel, A, Ade, P, Aghanim, N, Alves, M, Aniano, G, Arnaud, M, Ashdown, M, Aumont, J, Baccigalupi, C, Banday, A, Barreiro, R, Bartlett, J, Battaner, E, Benabed, K, Benoit-Levy, A, Bernard, J, Bersanelli, M, Bielewicz, P, Bobin, J, Bonaldi, A, Bond, J, Bouchet, F, Boulanger, F, Burigana, C, Cardoso, J, Catalano, A, Chamballu, A, Chiang, H, Christensen, P, Clements, D, Colombi, S, Colombo, L, Couchot, F, Crill, B, Cuttaia, F, Danese, L, Davis, R, De Bernardis, P, De Rosa, A, De Zotti, G, Delabrouille, J, Desert, F, Dickinson, C, Diego, J, Dole, H, Donzelli, S, Dore, O, Douspis, M, Dupac, X, Efstathiou, G, Ensslin, T, Eriksen, H, Falgarone, E, Finelli, F, Forni, O, Frailis, M, Franceschi, E, Galeotta, S, Ganga, K, Ghosh, T, Giard, M, Giraud-Heraud, Y, Gonzalez-Nuevo, J, Gorski, K, Gregorio, A, Gruppuso, A, Guillet, V, Hansen, F, Harrison, D, Helou, G, Henrot-Versille, S, Hernandez-Monteagudo, C, Herranz, D, Hildebrandt, S, Hivon, E, Hobson, M, Holmes, W, Hornstrup, A, Hovest, W, Huffenberger, K, Jaffe, A, Jaffe, T, Joncas, G, Jones, A, Jones, W, Juvela, M, Kalberla, P, Keihanen, E, Kerp, J, Keskitalo, R, Kisner, T, Kneissl, R, Knoche, J, Kunz, M, Kurki-Suonio, H, Lagache, G, Lahteenmaki, A, Lamarre, J, Lasenby, A, Lawrence, C, Leonardi, R, Levrier, F, Liguori, M, Lilje, P, Linden-Vornle, M, Lopez-Caniego, M, Lubin, P, Macias-Perez, J, Maffei, B, Maino, D, Mandolesi, N, Maris, M, Marshall, D, Martin, P, Martinez-Gonzalez, E, Masi, S, Massardi, M, Matarrese, S, Mazzotta, P, Melchiorri, A, Mendes, L, Mennella, A, Migliaccio, M, Mitra, S, Miville-Deschenes, M, Moneti, A, Montier, L, Morgante, G, Mortlock, D, Munshi, D, Murphy, J, Naselsky, P, Nati, F, Natoli, P, Noviello, F, Novikov, D, Novikov, I, Oxborrow, C, Pagano, L, Pajot, F, Paoletti, D, Pasian, F, Perdereau, O, Perotto, L, Perrotta, F, Piacentini, F, Piat, M, Pierpaoli, E, Pietrobon, D, Plaszczynski, S, Pointecouteau, E, Polenta, G, Ponthieu, N, Popa, L, Pratt, G, Prunet, S, Puget, J, Rachen, J, Reach, W, Rebolo, R, Reinecke, M, Remazeilles, M, Renault, C, Ricciardi, S, Riller, T, Ristorcelli, I, Rocha, G, Rosset, C, Roudier, G, Rusholme, B, Sandri, M, Savini, G, Spencer, L, Starck, J, Sureau, F, Sutton, D, Suur-Uski, A, Sygnet, J, Tauber, J, Terenzi, L, Toffolatti, L, Tomasi, M, Tristram, M, Tucci, M, Umana, G, Valenziano, L, Valiviita, J, Van Tent, B, Verstraete, L, Vielva, P, Villa, F, Wade, L, Wandelt, B, Winkel, B, Yvon, D, Zacchei, A, Zonca, A, Anne Lähteenmäki Group, Department of Radio Science and Engineering, Aalto-yliopisto, and Aalto University
Subjects: SOLAR NEIGHBORHOOD, Astronomy, diffuse backgrounds [Infrared], Astrophysics, cosmic background radiation, 7. Clean energy, 01 natural sciences, Far infrared, Astrophysics::Solar and Stellar Astrophysics, extinction / submillimeter: ISM / local insterstellar matter / infrared: diffuse background / cosmic background radiation, 010303 astronomy & astrophysics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Physics, education.field_of_study, Spectral index, Dust , extinction, local interstellar matter, extinction, Cosmic background radiation, Dust, extinction, Infrared: diffuse background, Local insterstellar matter, Submillimeter: ISM, Microwave frequencies, Electromagnetic wave emission, Wavelength, MOLECULAR-HYDROGEN, MAGELLANIC STREAM, MILKY-WAY, submillimeter: ISM, Astronomy and Astrophysics, Space and Planetary Science, dust, extinction, dust, Astrophysics::Earth and Planetary Astrophysics, [SDU.ASTR.GA]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], ANISOTROPY-PROBE, local insterstellar matter, Opacity, DATA RELEASE, Astrophysics::High Energy Astrophysical Phenomena, education, Carbon dust, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, NO, Settore FIS/05 - Astronomia e Astrofisica, diffuse background [infrared], 0103 physical sciences, Emissivity, Black-body radiation, ISM [submillimeter], Astrophysics::Galaxy Astrophysics, MAGNETIC NANOPARTICLES, 010308 nuclear & particles physics, Silicates, Amorphous carbon, BACKGROUND EXPERIMENT SEARCH, CENTIMETER EXCESS, 115 Astronomy, Space science, Astrophysics - Astrophysics of Galaxies, infrared: diffuse background, Interstellar medium, GALACTIC EMISSION, [PHYS.ASTR.GA]Physics [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], 13. Climate action, Astrophysics of Galaxies (astro-ph.GA), dust, extinction / submillimeter: ISM / local insterstellar matter / infrared: diffuse background / cosmic background radiation, Hydrogen, isms [Submillimeter], Galaxy Astrophysics
Abstract: The dust-Hi correlation is used to characterize the emission properties of dust in the diffuse interstellar medium (ISM) from far infrared wavelengths to microwave frequencies. The field of this investigation encompasses the part of the southern sky best suited to study the cosmic infrared and microwave backgrounds. We cross-correlate sky maps from Planck, the Wilkinson Microwave Anisotropy Probe (WMAP), and the diffuse infrared background experiment (DIRBE), at 17 frequencies from 23 to 3000 GHz, with the Parkes survey of the 21 cm line emission of neutral atomic hydrogen, over a contiguous area of 7500 deg2 centred on the southern Galactic pole. We present a general methodology to study the dust-H i correlation over the sky, including simulations to quantify uncertainties. Our analysis yields four specific results. (1) We map the temperature, submillimetre emissivity, and opacity of the dust per H-atom. The dust temperature is observed to be anti-correlated with the dust emissivity and opacity. We interpret this result as evidence of dust evolution within the diffuse ISM. The mean dust opacity is measured to be (7.1 ± 0.6) × 10-27 cm2 H-1 × (v/353 GHz) 1.53 ± 0.03for 100 ≤ v ≤ 353 GHz. This is a reference value to estimate hydrogen column densities from dust emission at submillimetre and millimetre wavelengths. (2) We map the spectral index βmm of dust emission at millimetre wavelengths (defined here as v ≤ 353GHz), and find it to be remarkably constant at βmm = 1.51 ± 0.13. We compare it with the far infrared spectral index βFIR derived from greybody fits at higher frequencies, and find a systematic difference, βmm -βFIR = -0.15, which suggests that the dust spectral energy distribution (SED) flattens at v ≤ 353 GHz. (3) We present spectral fits of the microwave emission correlated with Hi from 23 to 353 GHz, which separate dust and anomalous microwave emission (AME). We show that the flattening of the dust SED can be accounted for with an additional component with a blackbody spectrum. This additional component, which accounts for (26 ± 6)% of the dust emission at 100GHz, could represent magnetic dipole emission. Alternatively, it could account for an increasing contribution of carbon dust, or a flattening of the emissivity of amorphous silicates, at millimetre wavelengths. These interpretations make different predictions for the dust polarization SED. (4) We analyse the residuals of the dust-Hi correlation. We identify a Galactic contribution to these residuals, which we model with variations of the dust emissivity on angular scales smaller than that of our correlation analysis. This model of the residuals is used to quantify uncertainties of the CIB power spectrum in a companion Planck paper.© ESO 2014., The Planck Collaboration acknowledges support from: ESA; CNES and CNRS/INSU-IN2P3-INP (France); ASI, CNR, and INAF (Italy); NASA and DoE (USA); STFC and UKSA (UK); CSIC, MICINN and JA (Spain); Tekes, AoF and CSC (Finland); DLR and MPG (Germany); CSA (Canada); DTU Space (Denmark); SER/SSO (Switzerland); RCN (Norway); SFI (Ireland); FCT/MCTES (Portugal); and PRACE (EU). The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) / ERC grant agreement nº 267934.
Published: 2014

18. Planck intermediate results. XIV. Dust emission at millimetre wavelengths in the Galactic plane

Author: Planck, Collaboration, Ade, P. A. R., Aghanim, N., Alves, M. I. R., Arnaud, M., Ashdown, M., Atrio Barandela, F., Aumont, J., Baccigalupi, C., Banday, A. J., Barreiro, R. B., Bartlett, J. G., Battaner, E., Benabed, K., Benoit Levy, A., Bernard, J. P., Bersanelli, M., Bielewicz, P., Bobin, J., Bonaldi, A., Bond, J. R., Borrill, J., Bouchet, F. R., Boulanger, F., Bucher, M., Burigana, C., Butler, R. C., Cardoso, J. F., Catalano, A., Chamballu, A., Chiang, H. C., Chiang, L. Y., Christensen, P. R., Clements, D. L., Colombi, S., Colombo, L. P. L., Couchot, F., Crill, B. P., Curto, A., Cuttaia, F., Danese, L., Davies, R. D., Davis, R. J., DE BERNARDIS, Paolo, De Rosa, A., De Zotti, G., Delabrouille, J., Dickinson, C., Diego, J. M., Dole, H., Donzelli, S., Dore, O., Douspis, M., Dupac, X., Ensslin, T. A., Eriksen, H. K., Falgarone, E., Finelli, F., Forni, O., Frailis, M., Franceschi, E., Galeotta, S., Ganga, K., Ghosh, T., Giard, M., Giardino, G., Gonzalez Nuevo, J., Gorski, K. M., Gregorio, A., Gruppuso, A., Hansen, F. K., Harrison, D. L., Hernandez Monteagudo, C., Herranz, D., Hildebrandt, S. R., Hivon, E., Holmes, W. A., Hornstrup, A., Hovest, W., Jaffe, A. H., Jones, W. C., Juvela, M., Keihanen, E., Keskitalo, R., Kisner, T. S., Kneissl, R., Knoche, J., Kunz, M., Kurki Suonio, H., Lagache, G., Lahteenmaki, A., Lamarre, J. M., Lasenby, A., Laureijs, R. J., Lawrence, C. R., Leonardi, R., Levrier, F., Liguori, M., Lilje, P. B., Linden Vørnle, M., Linden Vornle, M., Lopez Caniego, M., Macias Perez, J. F., Maffei, B., Maino, D., Mandolesi, N., Maris, M., Marshall, D. J., Martin, P. G., Martinez Gonzalez, E., Masi, Silvia, Matarrese, S., Mazzotta, P., Melchiorri, Alessandro, Mendes, L., Mennella, A., Migliaccio, M., Mitra, S., Miville Deschenes, M. A., Moneti, A., Montier, L., Morgante, G., Mortlock, D., Munshi, D., Murphy, J. A., Naselsky, P., Nati, Federico, Natoli, P., Nørgaard Nielsen, H. U., Norgaard Nielsen, H. U., Noviello, F., Novikov, D., Novikov, I., Oxborrow, C. A., Pagano, Luca, Pajot, F., Paladini, R., Paoletti, D., Pasian, F., Patanchon, G., Peel, M., Perdereau, O., Perrotta, F., Piacentini, Francesco, Piat, M., Pierpaoli, E., Pietrobon, D., Plaszczynski, S., Pointecouteau, E., Polenta, Gianluca, Ponthieu, N., Popa, L., Pratt, G. W., Prunet, S., Puget, J. L., Rachen, J. P., Reach, W. T., Rebolo, R., Reinecke, M., Remazeilles, M., Renault, C., Ricciardi, Sara, Riller, T., Ristorcelli, I., Rocha, G., Rosset, C., Rubino Martin, J. A., Rusholme, B., Sandri, M., Savini, Giorgio, Scott, D., Spencer, L. D., Starck, J. L., Stolyarov, V., Sureau, F., Sutton, D., Suur Uski, A. S., Sygnet, J. F., Tauber, J. A., Tavagnacco, D., Terenzi, L., Toffolatti, L., Tomasi, M., Tristram, M., Tucci, M., Valenziano, L., Valiviita, J., Van Tent, B., Verstraete, L., Vielva, P., Villa, F., Vittorio, N., Wade, L. A., Wandelt, B. D., Yvon, D., Zacchei, A., Zonca, A., Ade, P, Aghanim, N, Alves, M, Arnaud, M, Ashdown, M, Atrio-Barandela, F, Aumont, J, Baccigalupi, C, Banday, A, Barreiro, R, Bartlett, J, Battaner, E, Benabed, K, Benoit-Levy, A, Bernard, J, Bersanelli, M, Bielewicz, P, Bobin, J, Bonaldi, A, Bond, J, Borrill, J, Bouchet, F, Boulanger, F, Bucher, M, Burigana, C, Butler, R, Cardoso, J, Catalano, A, Chamballu, A, Chiang, H, Chiang, L, Christensen, P, Clements, D, Colombi, S, Colombo, L, Couchot, F, Crill, B, Curto, A, Cuttaia, F, Danese, L, Davies, R, Davis, R, De Bernardis, P, De Rosa, A, De Zotti, G, Delabrouille, J, Dickinson, C, Diego, J, Dole, H, Donzelli, S, Dore, O, Douspis, M, Dupac, X, Ensslin, T, Eriksen, H, Falgarone, E, Finelli, F, Forni, O, Frailis, M, Franceschi, E, Galeotta, S, Ganga, K, Ghosh, T, Giard, M, Giardino, G, Gonzalez-Nuevo, J, Gorski, K, Gregorio, A, Gruppuso, A, Hansen, F, Harrison, D, Hernandez-Monteagudo, C, Herranz, D, Hildebrandt, S, Hivon, E, Holmes, W, Hornstrup, A, Hovest, W, Jaffe, A, Jones, W, Juvela, M, Keihanen, E, Keskitalo, R, Kisner, T, Kneissl, R, Knoche, J, Kunz, M, Kurki-Suonio, H, Lagache, G, Lahteenmaki, A, Lamarre, J, Lasenby, A, Laureijs, R, Lawrence, C, Leonardi, R, Levrier, F, Liguori, M, Lilje, P, Linden-Vornle, M, Lopez-Caniego, M, Macias-Perez, J, Maffei, B, Maino, D, Mandolesi, N, Maris, M, Marshall, D, Martin, P, Martinez-Gonzalez, E, Masi, S, Matarrese, S, Mazzotta, P, Melchiorri, A, Mendes, L, Mennella, A, Migliaccio, M, Mitra, S, Miville-Deschenes, M, Moneti, A, Montier, L, Morgante, G, Mortlock, D, Munshi, D, Murphy, J, Naselsky, P, Nati, F, Natoli, P, Norgaard-Nielsen, H, Noviello, F, Novikov, D, Novikov, I, Oxborrow, C, Pagano, L, Pajot, F, Paladini, R, Paoletti, D, Pasian, F, Patanchon, G, Peel, M, Perdereau, O, Perrotta, F, Piacentini, F, Piat, M, Pierpaoli, E, Pietrobon, D, Plaszczynski, S, Pointecouteau, E, Polenta, G, Ponthieu, N, Popa, L, Pratt, G, Prunet, S, Puget, J, Rachen, J, Reach, W, Rebolo, R, Reinecke, M, Remazeilles, M, Renault, C, Ricciardi, S, Riller, T, Ristorcelli, I, Rocha, G, Rosset, C, Rubino-Martin, J, Rusholme, B, Sandri, M, Savini, G, Scott, D, Spencer, L, Starck, J, Stolyarov, V, Sureau, F, Sutton, D, Suur-Uski, A, Sygnet, J, Tauber, J, Tavagnacco, D, Terenzi, L, Toffolatti, L, Tomasi, M, Tristram, M, Tucci, M, Valenziano, L, Valiviita, J, Van Tent, B, Verstraete, L, Vielva, P, Villa, F, Vittorio, N, Wade, L, Wandelt, B, Yvon, D, Zacchei, A, Zonca, A, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), APC - Gravitation (APC-Gravitation), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Centre National de la Recherche Scientifique (CNRS), PLANCK, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), École normale supérieure - Paris (ENS-PSL), Anne Lähteenmäki Group, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, APC - Cosmologie, Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), P. A. R., Ade, N., Aghanim, M. I. R., Alve, M., Arnaud, M., Ashdown, F., Atrio Barandela, J., Aumont, C., Baccigalupi, A. J., Banday, R. B., Barreiro, J. G., Bartlett, E., Battaner, K., Benabed, A., Benoit Lévy, J. P., Bernard, M., Bersanelli, P., Bielewicz, J., Bobin, A., Bonaldi, J. R., Bond, J., Borrill, F. R., Bouchet, F., Boulanger, M., Bucher, C., Burigana, R. C., Butler, J. F., Cardoso, A., Catalano, A., Chamballu, H. C., Chiang, L. Y., Chiang, P. R., Christensen, D. L., Clement, S., Colombi, L. P. L., Colombo, F., Couchot, B. P., Crill, A., Curto, F., Cuttaia, L., Danese, R. D., Davie, R. J., Davi, P., de Bernardi, A., de Rosa, G., de Zotti, J., Delabrouille, C., Dickinson, J. M., Diego, H., Dole, S., Donzelli, O., Doré, M., Douspi, X., Dupac, T. A., Enßlin, H. K., Eriksen, E., Falgarone, F., Finelli, O., Forni, M., Fraili, E., Franceschi, S., Galeotta, K., Ganga, T., Ghosh, M., Giard, G., Giardino, J., González Nuevo, K. M., Górski, Gregorio, Anna, A., Gruppuso, F. K., Hansen, D. L., Harrison, C., Hernández Monteagudo, D., Herranz, S. R., Hildebrandt, E., Hivon, W. A., Holme, A., Hornstrup, W., Hovest, A. H., Jaffe, W. C., Jone, M., Juvela, E., Keihänen, R., Keskitalo, T. S., Kisner, R., Kneissl, J., Knoche, M., Kunz, H., Kurki Suonio, G., Lagache, A., Lähteenmäki, J. M., Lamarre, A., Lasenby, R. J., Laureij, C. R., Lawrence, R., Leonardi, F., Levrier, M., Liguori, P. B., Lilje, M., Linden Vørnle, M., López Caniego, J. F., Macías Pérez, B., Maffei, D., Maino, N., Mandolesi, M., Mari, D. J., Marshall, P. G., Martin, E., Martínez González, S., Masi, S., Matarrese, P., Mazzotta, A., Melchiorri, L., Mende, A., Mennella, M., Migliaccio, S., Mitra, M. A., Miville Deschêne, A., Moneti, L., Montier, G., Morgante, D., Mortlock, D., Munshi, J. A., Murphy, P., Naselsky, F., Nati, P., Natoli, H. U., Nørgaard Nielsen, F., Noviello, D., Novikov, I., Novikov, C. A., Oxborrow, L., Pagano, F., Pajot, R., Paladini, D., Paoletti, F., Pasian, G., Patanchon, M., Peel, O., Perdereau, F., Perrotta, F., Piacentini, M., Piat, E., Pierpaoli, D., Pietrobon, S., Plaszczynski, E., Pointecouteau, G., Polenta, N., Ponthieu, L., Popa, G. W., Pratt, S., Prunet, J. L., Puget, J. P., Rachen, W. T., Reach, R., Rebolo, M., Reinecke, M., Remazeille, C., Renault, S., Ricciardi, T., Riller, I., Ristorcelli, G., Rocha, C., Rosset, J. A., Rubiño Martín, B., Rusholme, M., Sandri, G., Savini, D., Scott, L. D., Spencer, J. L., Starck, V., Stolyarov, F., Sureau, D., Sutton, A. S., Suur Uski, J. F., Sygnet, J. A., Tauber, Tavagnacco, Daniele, L., Terenzi, L., Toffolatti, M., Tomasi, M., Tristram, M., Tucci, L., Valenziano, J., Valiviita, B., Van Tent, L., Verstraete, P., Vielva, F., Villa, N., Vittorio, L. A., Wade, B. D., Wandelt, D., Yvon, A., Zacchei, A., Zonca, Department of Physics, and Helsinki Institute of Physics
Subjects: Galaxy: general, ISM: general, Radiation mechanisms: general, Radio continuum: ISM, Submillimeter: ISM, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics, ISM: general, Galaxy: general, radiation mechanisms: general, radio continuum: ISM, submillimeter: ISM, PRE-LAUNCH STATUS, SPECTRAL ENERGY-DISTRIBUTIONS, MU-M, MAGNETIC NANOPARTICLES, TEMPERATURE-DEPENDENCE, SUBMILLIMETER EXCESS, MICROWAVE EMISSION, INTERSTELLAR DUST, MAGELLANIC CLOUDS, MOLECULAR CLOUDS, 7. Clean energy, 01 natural sciences, Spectral line, Astronomy and Astrophysics, Space and Planetary Science, GAL OBSERVATIONS, Optical depth (astrophysics), Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, general [radiation mechanisms], Line (formation), Physics, Spectral index, general [ISM], radiation mechanisms: general, radio continuum: ISM, submillimeter: ISM, ASTRONOMY, Settore FIS/02 - Fisica Teorica, Modelli e Metodi Matematici, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Astrophysics::Earth and Planetary Astrophysics, INTERSTELLAR DUST, Astrophysics - Cosmology and Nongalactic Astrophysics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Opacity, Astrophysics::High Energy Astrophysical Phenomena, Milky Way, astro-ph.GA astro-ph.CO, education, MU-M, FOS: Physical sciences, ISM [radio continuum], SPECTRAL ENERGY-DISTRIBUTIONS, Astrophysics::Cosmology and Extragalactic Astrophysics, MICROWAVE EMISSION, NO, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Settore FIS/05 - Astronomia e Astrofisica, MAGELLANIC CLOUDS, 0103 physical sciences, PRE-LAUNCH STATUS, ISM [submillimeter], general [Galaxy], Astrophysics::Galaxy Astrophysics, Cosmic dust, MAGNETIC NANOPARTICLES, 010308 nuclear & particles physics, SUBMILLIMETER EXCESS, Galactic plane, 115 Astronomy, Space science, general, Galaxy: general, radiation mechanisms: general, radio continuum: ISM, submillimeter: ISM [ISM], Astrophysics - Astrophysics of Galaxies, TEMPERATURE-DEPENDENCE, 13. Climate action, Astrophysics of Galaxies (astro-ph.GA), MOLECULAR CLOUDS, ism:general, ism: general, radio continuum: ism, submillimeter: ism, galaxy: general, MAGELLANIC-CLOUD
Abstract: We use Planck HFI data combined with ancillary radio data to study the emissivity index of the interstellar dust emission in the frequency range 100.353 GHz, or 3.0.8 mm, in the Galactic plane. We analyse the region l = 20°44° and |b| ≤ 4° where the free-free emission can be estimated from radio recombination line data. We fit the spectra at each sky pixel with a modified blackbody model and two opacity spectral indices, βmm and βFIR, below and above 353 GHz, respectively. We find that βmm is smaller than βFIR, and we detect a correlation between this low frequency power-law index and the dust optical depth at 353 GHz, 353. The opacity spectral index βmm increases from about 1.54 in the more diffuse regions of the Galactic disk, |b| = 3°4° and τ353 ∼ 5 × 10-5, to about 1.66 in the densest regions with an optical depth of more than one order of magnitude higher. We associate this correlation with an evolution of the dust emissivity related to the fraction of molecular gas along the line of sight. This translates into βmm ∼ 1.54 for a medium that is mostly atomic and βmm ∼ 1.66 when the medium is dominated by molecular gas. We find that both the two-level system model and magnetic dipole emission by ferromagnetic particles can explain the results. These results improve our understanding of the physics of interstellar dust and lead towards a complete model of the dust spectrum of the Milky Way from far-infrared to millimetre wavelengths. © 2014 ESO., The Planck Collaboration acknowledges support from: ESA; CNES and CNRS/INSU-IN2P3-INP (France); ASI, CNR, and INAF (Italy); NASA and DoE (USA); STFC and UKSA (UK); CSIC, MICINN and JA (Spain); Tekes, AoF and CSC (Finland); DLR and MPG (Germany); CSA (Canada); DTU Space (Denmark); SER/SSO (Switzerland); RCN (Norway); SFI (Ireland); FCT/MCTES (Portugal); and DEISA (EU).
Published: 2014

19. Planck intermediate results. XV. A study of anomalous microwave emission in Galactic clouds

Author: Planck, Collaboration, Ade, P. A. R., Aghanim, N., Alves, M. I. R., Arnaud, M., Atrio Barandela, F., Aumont, J., Baccigalupi, C., Banday, A. J., Barreiro, R. B., Battaner, E., Benabed, K., Benoit Levy, A., Bernard, J. P., Bersanelli, M., Bielewicz, P., Bobin, J., Bonaldi, A., Bond, I. R., Bond, J. R., Borrill, J., Bouchet, F. R., Boulanger, E., Boulanger, F., Burigana, C., Cardoso, J. F., Casassus, S., Catalano, A., Chamballu, A., Chen, X., Chiang, H. C., Chiang, L. Y., Christensen, P. R., Clements, D. L., Colombi, S., Colombo, L. P. L., Couchot, F., Crill, B. P., Cuttaia, F., Danese, L., Davies, R. D., Davis, R. J., DE BERNARDIS, Paolo, De Rosa, A., De Zotti, G., Delabrouille, J., Desert, F. X., Dickinson, C., Diego, J. M., Donzelli, S., Dore, O., Dupac, X., Ensslin, T. A., Eriksen, H. K., Finelli, F., Forni, O., Franceschi, E., Galeotta, S., Ganga, K., Genova Santos, R. T., Ghosh, T., Giard, M., Gonzalez Nuevo, J., Gorski, K. M., Gregorio, A., Gruppuso, A., Hansen, E. K., Hansen, F. K., Harrison, D. L., Helou, G., Hernandez Monteagudo, C., Hildebrandt, S. R., Hivon, E., Hobson, M., Hornstrup, A., Jaffe, A. H., Jaffe, T. R., Jones, W. C., Keihanen, E., Keskitalo, R., Kneissl, R., Knoche, I., Knoche, J., Kunz, M., Kurki Suonio, H., Lahteenmaki, A., Lamarre, J. M., Lasenby, A., Lawrence, C. R., Leonardi, R., Liguori, M., Lilje, P. B., Linden Vørnle, M., Linden Vornle, M., Lopez Caniego, M., Macias Perez, J. F., Maffei, B., Maino, D., Mandolesi, N., Marshall, D. J., Martin, P. G., Martinez Gonzalez, E., Masi, Silvia, Massardi, M., Matarrese, S., Mazzotta, P., Meinhold, P. R., Melchiorri, Alessandro, Mendes, L., Mennella, A., Migliaccio, M., Miville Deschenes, M. A., Moneti, A., Montier, L., Morgante, G., Mortlock, D., Munshi, D., Naselsky, P., Nati, Federico, Natoli, P., Nørgaard Nielsen, H. U., Norgaard Nielsen, H. U., Noviello, F., Novikov, D., Novikov, I., Oxborrow, C. A., Pagano, Luca, Pajot, F., Paladini, R., Paoletti, D., Patanchon, G., Pearson, T. J., Peel, M., Perdereau, O., Perrotta, F., Piacentini, Francesco, Piat, M., Pierpaoli, E., Pietrobon, D., Plaszczynski, S., Pointecouteau, E., Polenta, Gianluca, Ponthieu, N., Popa, L., Pratt, G. W., Prunet, S., Puget, J. L., Rachen, J. P., Rebolo, R., Reich, W., Reinecke, M., Remazeilles, M., Renault, C., Ricciardi, Sara, Riller, T., Ristorcelli, I., Rocha, G., Rosset, C., Roudier, G., Rubino Martin, J. A., Rusholme, B., Sandri, M., Savini, G., Scott, D., Spencer, L. D., Stolyarov, V., Sutton, D., Suur Uski, A. S., Sygnet, J. F., Tauber, J. A., Tavagnacco, D., Terenzi, L., Tibbs, C. T., Toffolatti, L., Tomasi, M., Tristram, M., Tucci, M., Valenziano, L., Valiviita, J., Van Tent, B., Varis, J., Verstraete, L., Vielva, P., Villa, F., Wandelt, B. D., Watson, R., Wilkinson, A., Ysard, N., Yvon, D., Zacchei, A., Zonca, A., AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), APC - Gravitation (APC-Gravitation), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, APC - Cosmologie, Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PLANCK, Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), European Commission, Department of Physics, Helsinki Institute of Physics, Ade, P, Aghanim, N, Alves, M, Arnaud, M, Atrio-Barandela, F, Aumont, J, Baccigalupi, C, Banday, A, Barreiro, R, Battaner, E, Benabed, K, Benoit-Levy, A, Bernard, J, Bersanelli, M, Bielewicz, P, Bobin, J, Bonaldi, A, Bond, J, Borrill, J, Bouchet, F, Boulanger, F, Burigana, C, Cardoso, J, Casassus, S, Catalano, A, Chamballu, A, Chen, X, Chiang, H, Chiang, L, Christensen, P, Clements, D, Colombi, S, Colombo, L, Couchot, F, Crill, B, Cuttaia, F, Danese, L, Davies, R, Davis, R, De Bernardis, P, De Rosa, A, De Zotti, G, Delabrouille, J, Desert, F, Dickinson, C, Diego, J, Donzelli, S, Dore, O, Dupac, X, Ensslin, T, Eriksen, H, Finelli, F, Forni, O, Franceschi, E, Galeotta, S, Ganga, K, Genova-Santos, R, Ghosh, T, Giard, M, Gonzalez-Nuevo, J, Gorski, K, Gregorio, A, Gruppuso, A, Hansen, F, Harrison, D, Helou, G, Hernandez-Monteagudo, C, Hildebrandt, S, Hivon, E, Hobson, M, Hornstrup, A, Jaffe, A, Jaffe, T, Jones, W, Keihanen, E, Keskitalo, R, Kneissl, R, Knoche, J, Kunz, M, Kurki-Suonio, H, Lahteenmaki, A, Lamarre, J, Lasenby, A, Lawrence, C, Leonardi, R, Liguori, M, Lilje, P, Linden-Vornle, M, Lopez-Caniego, M, MacIas-Perez, J, Maffei, B, Maino, D, Mandolesi, N, Marshall, D, Martin, P, Martinez-Gonzalez, E, Masi, S, Massardi, M, Matarrese, S, Mazzotta, P, Meinhold, P, Melchiorri, A, Mendes, L, Mennella, A, Migliaccio, M, Miville-Deschenes, M, Moneti, A, Montier, L, Morgante, G, Mortlock, D, Munshi, D, Naselsky, P, Nati, F, Natoli, P, Norgaard-Nielsen, H, Noviello, F, Novikov, D, Novikov, I, Oxborrow, C, Pagano, L, Pajot, F, Paladini, R, Paoletti, D, Patanchon, G, Pearson, T, Peel, M, Perdereau, O, Perrotta, F, Piacentini, F, Piat, M, Pierpaoli, E, Pietrobon, D, Plaszczynski, S, Pointecouteau, E, Polenta, G, Ponthieu, N, Popa, L, Pratt, G, Prunet, S, Puget, J, Rachen, J, Rebolo, R, Reich, W, Reinecke, M, Remazeilles, M, Renault, C, Ricciardi, S, Riller, T, Ristorcelli, I, Rocha, G, Rosset, C, Roudier, G, Rubino-Martin, J, Rusholme, B, Sandri, M, Savini, G, Scott, D, Spencer, L, Stolyarov, V, Sutton, D, Suur-Uski, A, Sygnet, J, Tauber, J, Tavagnacco, D, Terenzi, L, Tibbs, C, Toffolatti, L, Tomasi, M, Tristram, M, Tucci, M, Valenziano, L, Valiviita, J, Van Tent, B, Varis, J, Verstraete, L, Vielva, P, Villa, F, Wandelt, B, Watson, R, Wilkinson, A, Ysard, N, Yvon, D, Zacchei, A, Zonca, A, P. A. R., Ade, N., Aghanim, M. I. R., Alve, M., Arnaud, F., Atrio Barandela, J., Aumont, C., Baccigalupi, A. J., Banday, R. B., Barreiro, E., Battaner, K., Benabed, A., Benoit Lévy, J. P., Bernard, M., Bersanelli, P., Bielewicz, J., Bobin, A., Bonaldi, J. R., Bond, J., Borrill, F. R., Bouchet, F., Boulanger, C., Burigana, J. F., Cardoso, S., Casassu, A., Catalano, A., Chamballu, X., Chen, H. C., Chiang, L. Y., Chiang, P. R., Christensen, D. L., Clement, S., Colombi, L. P. L., Colombo, F., Couchot, B. P., Crill, F., Cuttaia, L., Danese, R. D., Davie, R. J., Davi, P., de Bernardi, A., de Rosa, G., de Zotti, J., Delabrouille, F. X., Désert, C., Dickinson, J. M., Diego, S., Donzelli, O., Doré, X., Dupac, T. A., Enßlin, H. K., Eriksen, F., Finelli, O., Forni, E., Franceschi, S., Galeotta, K., Ganga, R. T., Génova Santo, T., Ghosh, M., Giard, J., González Nuevo, K. M., Górski, Gregorio, Anna, A., Gruppuso, F. K., Hansen, D. L., Harrison, G., Helou, C., Hernández Monteagudo, S. R., Hildebrandt, E., Hivon, M., Hobson, A., Hornstrup, A. H., Jaffe, T. R., Jaffe, W. C., Jone, E., Keihänen, R., Keskitalo, R., Kneissl, J., Knoche, M., Kunz, H., Kurki Suonio, A., Lähteenmäki, J. M., Lamarre, A., Lasenby, C. R., Lawrence, R., Leonardi, M., Liguori, P. B., Lilje, M., Linden Vørnle, M., López Caniego, J. F., Macías Pérez, B., Maffei, D., Maino, N., Mandolesi, D. J., Marshall, P. G., Martin, E., Martínez González, S., Masi, M., Massardi, S., Matarrese, P., Mazzotta, P. R., Meinhold, A., Melchiorri, L., Mende, A., Mennella, M., Migliaccio, M. A., Miville Deschêne, A., Moneti, L., Montier, G., Morgante, D., Mortlock, D., Munshi, P., Naselsky, F., Nati, P., Natoli, H. U., Nørgaard Nielsen, F., Noviello, D., Novikov, I., Novikov, C. A., Oxborrow, L., Pagano, F., Pajot, R., Paladini, D., Paoletti, G., Patanchon, T. J., Pearson, M., Peel, O., Perdereau, F., Perrotta, F., Piacentini, M., Piat, E., Pierpaoli, D., Pietrobon, S., Plaszczynski, E., Pointecouteau, G., Polenta, N., Ponthieu, L., Popa, G. W., Pratt, S., Prunet, J. L., Puget, J. P., Rachen, R., Rebolo, W., Reich, M., Reinecke, M., Remazeille, C., Renault, S., Ricciardi, T., Riller, I., Ristorcelli, G., Rocha, C., Rosset, G., Roudier, J. A., Rubiño Martín, B., Rusholme, M., Sandri, G., Savini, D., Scott, L. D., Spencer, V., Stolyarov, D., Sutton, A. S., Suur Uski, J. F., Sygnet, J. A., Tauber, Tavagnacco, Daniele, L., Terenzi, C. T., Tibb, L., Toffolatti, M., Tomasi, M., Tristram, M., Tucci, L., Valenziano, J., Valiviita, B., Van Tent, J., Vari, L., Verstraete, P., Vielva, F., Villa, B. D., Wandelt, R., Watson, A., Wilkinson, N., Ysard, D., Yvon, A., Zacchei, A., Zonca, Anne Lähteenmäki Group, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI)
Subjects: CENTIMETER-WAVE CONTINUUM, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astronomy, Cosmic microwave background, Astrophysics, 01 natural sciences, 7. Clean energy, HII regions, Radiation mechanisms: general, Radio continuum: ISM, Submillimeter: ISM, submillimeter, general, Radio continuum: ISM, Submillimeter: ISM [HII regions, Radiation mechanisms], SPINNING DUST EMISSION, 010303 astronomy & astrophysics, general [Radiation mechanisms], Physics, Nebula, HII regions, Radiation mechanisms: general, Radio continuum: ISM, Submillimeter: ISM, Astronomy and Astrophysics, Space and Planetary Science, Spinning dust, FOREGROUND EMISSION, ISM [Submillimeter], 3. Good health, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Astrophysics::Earth and Planetary Astrophysics, ANISOTROPY-PROBE, education, radio continuum: ism, hii regions, radiation mechanisms: general, submillimeter: ism, submillimiter: ism, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, radio continuum, NO, STAR-FORMATION, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], H-II REGIONS, Settore FIS/05 - Astronomia e Astrofisica, GHZ SKY SURVEY, Dark nebula, 0103 physical sciences, Emissivity, PRE-LAUNCH STATUS, HII region, Astrophysics::Galaxy Astrophysics, Infrared excess, 010308 nuclear & particles physics, Molecular cloud, 115 Astronomy, Space science, Astrophysics - Astrophysics of Galaxies, ISM [Radio continuum], Interstellar medium, radiation mechanisms, 13. Climate action, Astrophysics of Galaxies (astro-ph.GA), PROBE WMAP OBSERVATIONS, HII regions / radiation mechanisms: general / radio continuum: ISM / submillimeter: ISM, MOLECULAR CLOUDS
Abstract: Anomalous microwave emission (AME) is believed to be due to electric dipole radiation from small spinning dust grains. The aim of this paper is a statistical study of the basic properties of AME regions and the environment in which they emit. We used WMAP and Planck maps, combined with ancillary radio and IR data, to construct a sample of 98 candidate AME sources, assembling SEDs for each source using aperture photometry on 1°-smoothed maps from 0.408â‰ GHz up to 3000 GHz. Each spectrum is fitted with a simple model of free-free, synchrotron (where necessary), cosmic microwave background (CMB), thermal dust, and spinning dust components. We find that 42 of the 98 sources have significant (>5σ) excess emission at frequencies between 20 and 60 GHz. An analysis of the potential contribution of optically thick free-free emission from ultra-compact H ii regions, using IR colour criteria, reduces the significant AME sample to 27 regions. The spectrum of the AME is consistent with model spectra of spinning dust. Peak frequencies are in the range 20-35 GHz except for the California nebula (NGC 1499), which appears to have a high spinning dust peak frequency of (50 ± 17) GHz. The AME regions tend to be more spatially extended than regions with little or no AME. The AME intensity is strongly correlated with the sub-millimetre/IR flux densities and comparable to previous AME detections in the literature. AME emissivity, defined as the ratio of AME to dust optical depth, varies by an order of magnitude for the AME regions. The AME regions tend to be associated with cooler dust in the range 14-20 K and an average emissivity index, βd, of +1.8, while the non-AME regions are typically warmer, at 20-27 K. In agreement with previous studies, the AME emissivity appears to decrease with increasing column density. This supports the idea of AME originating from small grains that are known to be depleted in dense regions, probably due to coagulation onto larger grains. We also find a correlation between the AME emissivity (and to a lesser degree the spinning dust peak frequency) and the intensity of the interstellar radiation field, G0. Modelling of this trend suggests that both radiative and collisional excitation are important for the spinning dust emission. The most significant AME regions tend to have relatively less ionized gas (free-free emission), although this could be a selection effect. The infrared excess, a measure of the heating of dust associated with H ii regions, is typically >4 for AME sources, indicating that the dust is not primarily heated by hot OB stars. The AME regions are associated with known dark nebulae and have higher 12 μm/25 μm ratios. The emerging picture is that the bulk of the AME is coming from the polycyclic aromatic hydrocarbons and small dust grains from the colder neutral interstellar medium phase. © 2014 ESO., C.D. acknowledges an STFC Advanced Fellowship, an EU Marie-Curie IRG grant under the FP7, and an ERC Starting Grant (No. 307209). The Planck Collaboration acknowledges support from: ESA; CNES and CNRS/INSU-IN2P3-INP (France); ASI, CNR, and INAF (Italy); NASA and DoE (USA); STFC and UKSA (UK); CSIC, MICINN and JA (Spain); Tekes, AoF and CSC (Finland); DLR and MPG (Germany); CSA (Canada); DTU Space (Denmark); SER/SSO (Switzerland); RCN (Norway); SFI (Ireland); FCT/MCTES (Portugal); and PRACE (EU).
Published: 2014

20. Planck intermediate results XVI. Profile likelihoods for cosmological parameters

Author: Planck, Collaboration, Ade, P. A. R., Aghanim, N., Arnaud, M., Ashdown, M., Aumont, J., Baccigalupi, C., Banday, A. J., Barreiro, R. B., Bartlett, J. G., Battaner, E., Benabed, K., Benoit Levy, A., Bernard, J. P., Bersanelli, M., Bielewicz, P., Bobin, J., Bonaldi, A., Bond, J. R., Bouchet, F. R., Burigana, C., Cardoso, J. F., Catalano, Andrea, Chamballu, A., Chiang, H. C., Christensen, P. R., Clements, D. L., Colombi, S., Colombo, L. P. L., Couchot, F., Cuttaia, F., Danese, L., Davies, R. D., Davis, R. J., DE BERNARDIS, Paolo, De Rosa, A., De Zotti, G., Delabrouille, J., Dickinson, C., Diego, J. M., Dole, H., Donzelli, S., Dore, O., Douspis, M., Dupac, X., Ensslin, T. A., Eriksen, H. K., Finelli, F., Forni, O., Frailis, M., Franceschi, E., Galeotta, S., Silvia, Galli, Ganga, K., Giard, M., Giraud Heraud, Y., Gonzalez Nuevo, J., Gorski, K. M., Gregorio, A., Gruppuso, A., Hansen, F. K., Harrison, D. L., Henrot Versille, S., Hernandez Monteagudo, C., Herranz, D., Hildebrandt, S. R., Hivon, E., Hobson, M., Holmes, W. A., Hornstrup, A., Hovest, W., Huffenberger, K. M., Jaffe, A. H., Jaffe, T. R., Jones, W. C., Juvela, M., Keihanen, E., Keskitalo, R., Kisner, T. S., Kneissl, R., Knoche, J., Knox, L., Kunz, M., Kurki Suonio, H., Lagache, G., Lahteenmaki, A., Lamarre, J. M., Lasenby, A., Lawrence, C. R., Leonardi, R., Liddle, A., Liguori, M., Lilje, P. B., Linden Vornle, M., Linden Vørnle, M., Lopez Caniego, M., Lubin, P. M., Macias Perez, J. F., Maffei, B., Maino, D., Mandolesi, N., Maris, M., Martin, P. G., Martinez Gonzalez, E., Masi, Silvia, Massardi, M., Matarrese, S., Mazzotta, P., Melchiorri, Alessandro, Mendes, L., Mennella, A., Migliaccio, M., Mitra, S., Miville Deschenes, M. A., Moneti, A., Montier, L., Morgante, G., Munshi, D., Murphy, J. A., Naselsky, P., Nati, Federico, Natoli, P., Noviello, F., Novikov, D., Novikov, I., Oxborrow, C. A., Pagano, Luca, Pajot, F., Paoletti, D., Pasian, F., Perdereau, O., Perotto, L., Perrotta, F., Pettorino, V., Piacentini, Francesco, Piat, M., Pierpaoli, E., Pietrobon, D., Plaszczynski, S., Pointecouteau, E., Polenta, Gianluca, Popa, L., Pratt, G. W., Puget, J. L., Rachen, J. P., Rebolo, R., Reinecke, M., Remazeilles, M., Renault, C., Ricciardi, Sara, Riller, T., Ristorcelli, I., Rocha, G., Rosset, C., Roudier, G., D'Orfeuil, B. R., Rouille D'Orfeuil, B., Rubino Martin, J. A., Rusholme, B., Sandri, M., Savelainen, M., Savini, Giorgio, Spencer, L. D., Spinelli, M., Starck, J. L., Sureau, F., Sutton, D., Suur Uski, A. S., Sygnet, J. F., Tauber, J. A., Terenzi, L., Toffolatti, L., Tomasi, M., Tristram, M., Tucci, M., Umana, G., Valenziano, L., Valiviita, J., Van Tent, B., Vielva, P., Villa, F., Wade, L. A., Wandelt, B. D., White, M., Yvon, D., Zacchei, A., Zonca, A., Ade, P, Aghanim, N, Arnaud, M, Ashdown, M, Aumont, J, Baccigalupi, C, Banday, A, Barreiro, R, Bartlett, J, Battaner, E, Benabed, K, Benoit-Levy, A, Bernard, J, Bersanelli, M, Bielewicz, P, Bobin, J, Bonaldi, A, Bond, J, Bouchet, F, Burigana, C, Cardoso, J, Catalano, A, Chamballu, A, Chiang, H, Christensen, P, Clements, D, Colombi, S, Colombo, L, Couchot, F, Cuttaia, F, Danese, L, Davies, R, Davis, R, De Bernardis, P, De Rosa, A, De Zotti, G, Delabrouille, J, Dickinson, C, Diego, J, Dole, H, Donzelli, S, Dore, O, Douspis, M, Dupac, X, Ensslin, T, Eriksen, H, Finelli, F, Forni, O, Frailis, M, Franceschi, E, Galeotta, S, Galli, S, Ganga, K, Giard, M, Giraud-Heraud, Y, Gonzalez-Nuevo, J, Gorski, K, Gregorio, A, Gruppuso, A, Hansen, F, Harrison, D, Henrot-Versille, S, Hernandez-Monteagudo, C, Herranz, D, Hildebrandt, S, Hivon, E, Hobson, M, Holmes, W, Hornstrup, A, Hovest, W, Huffenberger, K, Jaffe, A, Jaffe, T, Jones, W, Juvela, M, Keihanen, E, Keskitalo, R, Kisner, T, Kneissl, R, Knoche, J, Knox, L, Kunz, M, Kurki-Suonio, H, Lagache, G, Lahteenmaki, A, Lamarre, J, Lasenby, A, Lawrence, C, Leonardi, R, Liddle, A, Liguori, M, Lilje, P, Linden-Vornle, M, Lopez-Caniego, M, Lubin, P, Macias-Perez, J, Maffei, B, Maino, D, Mandolesi, N, Maris, M, Martin, P, Martinez-Gonzalez, E, Masi, S, Massardi, M, Matarrese, S, Mazzotta, P, Melchiorri, A, Mendes, L, Mennella, A, Migliaccio, M, Mitra, S, Miville-Deschenes, M, Moneti, A, Montier, L, Morgante, G, Munshi, D, Murphy, J, Naselsky, P, Nati, F, Natoli, P, Noviello, F, Novikov, D, Novikov, I, Oxborrow, C, Pagano, L, Pajot, F, Paoletti, D, Pasian, F, Perdereau, O, Perotto, L, Perrotta, F, Pettorino, V, Piacentini, F, Piat, M, Pierpaoli, E, Pietrobon, D, Plaszczynski, S, Pointecouteau, E, Polenta, G, Popa, L, Pratt, G, Puget, J, Rachen, J, Rebolo, R, Reinecke, M, Remazeilles, M, Renault, C, Ricciardi, S, Riller, T, Ristorcelli, I, Rocha, G, Rosset, C, Roudier, G, Rouille D'orfeuil, B, Rubino-Martin, J, Rusholme, B, Sandri, M, Savelainen, M, Savini, G, Spencer, L, Spinelli, M, Starck, J, Sureau, F, Sutton, D, Suur-Uski, A, Sygnet, J, Tauber, J, Terenzi, L, Toffolatti, L, Tomasi, M, Tristram, M, Tucci, M, Umana, G, Valenziano, L, Valiviita, J, Van Tent, B, Vielva, P, Villa, F, Wade, L, Wandelt, B, White, M, Yvon, D, Zacchei, A, Zonca, A, APC - Cosmologie, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), APC - Gravitation (APC-Gravitation), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, PLANCK, Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), P. A. R., Ade, N., Aghanim, M., Arnaud, M., Ashdown, J., Aumont, C., Baccigalupi, A. J., Banday, R. B., Barreiro, J. G., Bartlett, E., Battaner, K., Benabed, A., Benoit Lévy, J. P., Bernard, M., Bersanelli, P., Bielewicz, J., Bobin, A., Bonaldi, J. R., Bond, F. R., Bouchet, C., Burigana, J. F., Cardoso, A., Catalano, A., Chamballu, H. C., Chiang, P. R., Christensen, D. L., Clement, S., Colombi, L. P. L., Colombo, F., Couchot, F., Cuttaia, L., Danese, R. D., Davie, R. J., Davi, P., de Bernardi, A., de Rosa, G., de Zotti, J., Delabrouille, C., Dickinson, J. M., Diego, H., Dole, S., Donzelli, O., Doré, M., Douspi, X., Dupac, T. A., Enßlin, H. K., Eriksen, F., Finelli, O., Forni, M., Fraili, E., Franceschi, S., Galeotta, S., Galli, K., Ganga, M., Giard, Y., Giraud Héraud, J., González Nuevo, K. M., Górski, Gregorio, Anna, A., Gruppuso, F. K., Hansen, D. L., Harrison, S., Henrot Versillé, C., Hernández Monteagudo, D., Herranz, S. R., Hildebrandt, E., Hivon, M., Hobson, W. A., Holme, A., Hornstrup, W., Hovest, K. M., Huffenberger, A. H., Jaffe, T. R., Jaffe, W. C., Jone, M., Juvela, E., Keihänen, R., Keskitalo, T. S., Kisner, R., Kneissl, J., Knoche, L., Knox, M., Kunz, H., Kurki Suonio, G., Lagache, A., Lähteenmäki, J. M., Lamarre, A., Lasenby, C. R., Lawrence, R., Leonardi, A., Liddle, M., Liguori, P. B., Lilje, M., Linden Vørnle, M., López Caniego, P. M., Lubin, J. F., Macías Pérez, B., Maffei, D., Maino, N., Mandolesi, M., Mari, P. G., Martin, E., Martínez González, S., Masi, M., Massardi, S., Matarrese, P., Mazzotta, A., Melchiorri, L., Mende, A., Mennella, M., Migliaccio, S., Mitra, M. A., Miville Deschêne, A., Moneti, L., Montier, G., Morgante, D., Munshi, J. A., Murphy, P., Naselsky, F., Nati, P., Natoli, F., Noviello, D., Novikov, I., Novikov, C. A., Oxborrow, L., Pagano, F., Pajot, D., Paoletti, F., Pasian, O., Perdereau, L., Perotto, F., Perrotta, V., Pettorino, F., Piacentini, M., Piat, E., Pierpaoli, D., Pietrobon, S., Plaszczynski, E., Pointecouteau, G., Polenta, L., Popa, G. W., Pratt, J. L., Puget, J. P., Rachen, R., Rebolo, M., Reinecke, M., Remazeille, C., Renault, S., Ricciardi, T., Riller, I., Ristorcelli, G., Rocha, C., Rosset, G., Roudier, B., Rouillé d’Orfeuil, J. A., Rubiño Martín, B., Rusholme, M., Sandri, M., Savelainen, G., Savini, L. D., Spencer, M., Spinelli, J. L., Starck, F., Sureau, D., Sutton, A. S., Suur Uski, J. F., Sygnet, J. A., Tauber, L., Terenzi, L., Toffolatti, M., Tomasi, M., Tristram, M., Tucci, G., Umana, L., Valenziano, J., Valiviita, B., Van Tent, P., Vielva, F., Villa, L. A., Wade, B. D., Wandelt, M., White, D., Yvon, A., Zacchei, A., Zonca, Department of Physics, and Helsinki Institute of Physics
Subjects: statistical [Methods], Cosmological parameter, Statistical methods, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astronomy, Cosmic microwave background, Astrophysics, Cosmic background radiation, 7. Clean energy, Cosmology: observation, Cosmological parameters, Cosmology: observations, Cosmology: theory, Methods: statistical, Astronomy and Astrophysics, Space and Planetary Science, Cosmic ray measurement, Statistical physics, Limit (mathematics), observations [Cosmology], cosmology: theory, cosmology: observations, cosmic background radiation, cosmological parameters, methods: statistical, Physics, Mass distribution, Cosmology, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, symbols, astro-ph.CO, Neutrino, Likelihood function, Astrophysics - Cosmology and Nongalactic Astrophysics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), education, Bayesian probability, FOS: Physical sciences, observation [Cosmology], Astrophysics::Cosmology and Extragalactic Astrophysics, NO, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, Frequentist inference, theory [Cosmology], Planck, 115 Astronomy, Space science, 13. Climate action, DARK ENERGY, BARYON ACOUSTIC-OSCILLATIONS, cosmic background radiation / cosmology: observations / cosmology: theory / cosmological parameters / methods: statistical
Abstract: We explore the 2013 Planck likelihood function with a high-precision multi-dimensional minimizer (Minuit). This allows a refinement of the CDM best-fit solution with respect to previously-released results, and the construction of frequentist confidence intervals using profile likelihoods. The agreement with the cosmological results from the Bayesian framework is excellent, demonstrating the robustness of the Planck results to the statistical methodology. We investigate the inclusion of neutrino masses, where more significant differences may appear due to the non-Gaussian nature of the posterior mass distribution. By applying the Feldman-Cousins prescription, we again obtain results very similar to those of the Bayesian methodology. However, the profile-likelihood analysis of the cosmic microwave background (CMB) combination (Planck+WP+highL) reveals a minimum well within the unphysical negative-mass region. We show that inclusion of the Planck CMB-lensing information regularizes this issue, and provide a robust frequentist upper limit σmv ≤0:26 eV (95% confidence) from the CMB+lensing+BAO data combination. © ESO 2014., The development of Planck has been supported by: ESA; CNES and CNRS/INSU-IN2P3-INP (France); ASI, CNR, and INAF (Italy); NASA and DoE (USA); STFC and UKSA (UK); CSIC, MICINN and JA (Spain); Tekes, AoF and CSC (Finland); DLR and MPG (Germany); CSA (Canada); DTU Space (Denmark); SER/SSO (Switzerland); RCN (Norway); SFI (Ireland); FCT/MCTES (Portugal); and PRACE (EU).
Published: 2014

21. Planck intermediate results. IX. Detection of the Galactic haze with Planck

Author: Planck, Collaboration, Ade, P. A. R., Aghanim, N., Arnaud, M., Ashdown, M., Atrio Barandela, F., Aumont, J., Baccigalupi, C., Balbi, A., Banday, A. J., Barreiro, R. B., Bartlett, J. G., Battaner, E., Benabed, K., Benoit, A., Bernard, J. P., Bersanelli, M., Bonaldi, A., Bond, J. R., Borrill, J., Bouchet, F. R., Burigana, C., Cabella, P., Cardoso, J. F., Catalano, Andrea, Cayon, L., Chary, R. R., Chiang, L. Y., Christensen, P. R., Clements, D. L., Colombo, L. P. L., Coulais, A., Crill, B. P., Cuttaia, F., Danese, L., D'Arcangelo, O., Davis, R. J., DE BERNARDIS, Paolo, De Gasperis, G., De Rosa, A., De Zotti, G., Delabrouille, J., Dickinson, C., Diego, J. M., Dobler, G., Dole, H., Donzelli, S., Dore, O., Dorl, U., Douspis, M., Dupac, X., Efstathiou, G., Ensslin, T. A., Eriksen, H. K., Finelli, F., Forni, O., Frailis, M., Franceschi, E., Galeotta, S., Ganga, K., Giard, M., Giardino, G., Gonzalez Nuevo, J., Gonzaalez Nuevo, J., Gorski, K. M., Gratton, S., Gregorio, A., Gruppuso, A., Hansen, F. K., Harrison, D., Helou, G., Henrot Versille, S., Hernandez Monteagudo, C., Hildebrandt, S. R., Hivon, E., Hobson, M., Holmes, W. A., Hornstrup, A., Hovest, W., Huffenberger, K. M., Jaffe, T. R., Jagemann, T., Jewell, J., Jones, W. C., Juvela, M., Keihanen, E., Keihacn, E., Knoche, J., Knox, L., Kunz, M., Kurki Suonio, H., Lagache, G., Lahteenmaki, A., Lamarre, J. M., Lasenby, A., Lawrence, C. R., Leach, S., Leonardi, R., Lilje, P. B., Linden Vørnle, M., Linden Vornle, M., Lopez Caniego, M., Lubin, P. M., Macias Perez, J. F., Maffei, B., Maino, D., Mandolesi, N., Maris, M., Marshall, D. J., Martin, P. G., Martinez Gonzalez, E., Masi, Silvia, Massardi, M., Matarrese, S., Matthai, F., Mazzotta, P., Meinhold, P. R., Melchiorri, Alessandro, Mendes, L., Mennella, A., Mitra, S., Moneti, A., Montier, L., Morgante, G., Munshi, D., Murphy, J. A., Naselsky, P., Natoli, P., Nørgaard Nielsen, H. U., Norgaard Nielsen, H. U., Noviello, F., Novikov, D., Novikov, I., Osborne, S., Pajot, F., Paladini, R., Paoletti, D., Partridge, B., Pearson, T. J., Perdereau, O., Perrotta, F., Piacentini, Francesco, Piat, M., Pierpaoli, E., Pietrobon, D., Plaszczynski, S., Pointecouteau, E., Polenta, Gianluca, Ponthieu, N., Popa, L., Poutanen, T., Pratt, G. W., Prunet, S., Puget, J. L., Rachen, J. P., Rebolo, R., Reinecke, M., Renault, C., Ricciardi, Sara, Riller, T., Ristorcelli, I., Rocha, G., Rosset, C., Rubino Martin, J. A., Rusholme, B., Sandri, M., Savini, Giorgio, Schaefer, B. M., Scott, D., Smoot, G. F., Spencer, L., Stivoli, Federico, Sudiwala, R., Suur Uski, A. S., Sygnet, J. F., Tauber, J. A., Terenzi, L., Toffolatti, L., Tomasi, M., Tristram, M., Turler, M., Umana, G., Valenziano, L., Van Tent, B., Vielva, P., Villa, F., Vittorio, N., Wade, L. A., Wandelt, B. D., White, M., Yvon, D., Zacchei, A., Zonca, A., APC - Cosmologie, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Hélium : du fondamental aux applications (HELFA), Institut Néel (NEEL), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), APC - Gravitation (APC-Gravitation), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), PLANCK, Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), HELFA - Hélium : du fondamental aux applications, Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Department of Physics, Helsinki Institute of Physics, P. A. R., Ade, N., Aghanim, M., Arnaud, M., Ashdown, F., Atrio Barandela, J., Aumont, C., Baccigalupi, A., Balbi, A. J., Banday, R. B., Barreiro, J. G., Bartlett, E., Battaner, K., Benabed, A., Benoît, J. P., Bernard, M., Bersanelli, A., Bonaldi, J. R., Bond, J., Borrill, F. R., Bouchet, C., Burigana, P., Cabella, J. F., Cardoso, A., Catalano, L., Cayón, R. R., Chary, L. Y., Chiang, P. R., Christensen, D. L., Clement, L. P. L., Colombo, A., Coulai, B. P., Crill, F., Cuttaia, L., Danese, O., D’Arcangelo, R. J., Davi, P., de Bernardi, G., de Gasperi, A., de Rosa, G., de Zotti, J., Delabrouille, C., Dickinson, J. M., Diego, G., Dobler, H., Dole, S., Donzelli, O., Doré, U., Dörl, M., Douspi, X., Dupac, G., Efstathiou, T. A., Enßlin, H. K., Eriksen, F., Finelli, O., Forni, M., Fraili, E., Franceschi, S., Galeotta, K., Ganga, M., Giard, G., Giardino, J., González Nuevo, K. M., Górski, S., Gratton, Gregorio, Anna, A., Gruppuso, F. K., Hansen, D., Harrison, G., Helou, S., Henrot Versillé, C., Hernández Monteagudo, S. R., Hildebrandt, E., Hivon, M., Hobson, W. A., Holme, A., Hornstrup, W., Hovest, K. M., Huffenberger, T. R., Jaffe, T., Jagemann, J., Jewell, W. C., Jone, M., Juvela, E., Keihänen, J., Knoche, L., Knox, M., Kunz, H., Kurki Suonio, G., Lagache, A., Lähteenmäki, J. M., Lamarre, A., Lasenby, C. R., Lawrence, S., Leach, R., Leonardi, P. B., Lilje, M., Linden Vørnle, M., López Caniego, P. M., Lubin, J. F., Macías Pérez, B., Maffei, D., Maino, N., Mandolesi, M., Mari, D. J., Marshall, P. G., Martin, E., Martínez González, S., Masi, M., Massardi, S., Matarrese, F., Matthai, P., Mazzotta, P. R., Meinhold, A., Melchiorri, L., Mende, A., Mennella, S., Mitra, A., Moneti, L., Montier, G., Morgante, D., Munshi, J. A., Murphy, P., Naselsky, P., Natoli, H. U., Nørgaard Nielsen, F., Noviello, D., Novikov, I., Novikov, S., Osborne, F., Pajot, R., Paladini, D., Paoletti, B., Partridge, T. J., Pearson, O., Perdereau, F., Perrotta, F., Piacentini, M., Piat, E., Pierpaoli, D., Pietrobon, S., Plaszczynski, E., Pointecouteau, G., Polenta, N., Ponthieu, L., Popa, T., Poutanen, G. W., Pratt, S., Prunet, J. L., Puget, J. P., Rachen, R., Rebolo, M., Reinecke, C., Renault, S., Ricciardi, T., Riller, I., Ristorcelli, G., Rocha, C., Rosset, J. A., Rubiño Martín, B., Rusholme, M., Sandri, G., Savini, B. M., Schaefer, D., Scott, G. F., Smoot, L., Spencer, F., Stivoli, R., Sudiwala, A. S., Suur Uski, J. F., Sygnet, J. A., Tauber, L., Terenzi, L., Toffolatti, M., Tomasi, M., Tristram, M., Türler, G., Umana, L., Valenziano, B., Van Tent, P., Vielva, F., Villa, N., Vittorio, L. A., Wade, B. D., Wandelt, M., White, D., Yvon, A., Zacchei, A., Zonca, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Hélium : du fondamental aux applications (NEEL - HELFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Planck Collaboration, Anne Lähteenmäki Group, Aalto-yliopisto, and Aalto University
Subjects: radio continuum: ism, ism: bubbles, ism: structure, galaxy: nucleus, Haze, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astronomy, WMAP OBSERVATIONS, Astrophysics, 01 natural sciences, 010303 astronomy & astrophysics, nucleu [Galaxy], High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Spectral index, Galaxy: nucleus, POWER SPECTRUM ESTIMATION, BAYESIAN COMPONENT SEPARATION, FOREGROUND EMISSION, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], CMB cold spot, Galaxy: nucleus / ISM: structure / ISM: bubbles / radio continuum: ISM, ISM: structure, ISM: bubbles, radio continuum: ISM, bubbles [ISM], Supernova, SPINNING DUST GRAINS, Radio continuum: ISM, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, symbols, [SDU.ASTR.GA]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], Astrophysics::Earth and Planetary Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Cosmology and Nongalactic Astrophysics (astro-ph.CO), INTERSTELLAR-MEDIUM EMISSION, Astrophysics::High Energy Astrophysical Phenomena, education, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, NORTHERN SKY, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, bubble [ISM], PRE-LAUNCH STATUS, Planck, Disc, Astrophysics::Galaxy Astrophysics, TEMPERATURE DATA, nucleus [Galaxy], 010308 nuclear & particles physics, nucleus, Astronomy and Astrophysics, 115 Astronomy, Space science, Astrophysics - Astrophysics of Galaxies, MICROWAVE-ANISOTROPY-PROBE, ISM [Radio continuum], Galaxy, [PHYS.ASTR.GA]Physics [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), structure [ISM], Fermi Gamma-ray Space Telescope
Abstract: Using precise full-sky observations from Planck, and applying several methods of component separation, we identify and characterise the emission fromthe Galactic “haze” at microwave wavelengths. The haze is a distinct component of diffuse Galactic emission, roughly centered on the Galactic centre, and extends to |b| ∼ 35−50◦ in Galactic latitude and |l| ∼ 15−20◦ in longitude. By combining the Planck data with observations from the Wilkinson Microwave Anisotropy Probe, we were able to determine the spectrum of this emission to high accuracy, unhindered by the strong systematic biases present in previous analyses. The derived spectrum is consistent with power-law emission with a spectral index of −2.56 ± 0.05, thus excluding free-free emission as the source and instead favouring hard-spectrum synchrotron radiation from an electron population with a spectrum (number density per energy) dN/dE ∝ E−2.1. At Galactic latitudes |b| < 30◦, the microwave haze morphology is consistent with that of the Fermi gamma-ray “haze” or “bubbles”, while at b ∼ −50◦ we have identified an edge in the microwave haze that is spatially coincident with the edge in the gamma-ray bubbles. Taken together, this indicates that we have a multi-wavelength view of a distinct component of our Galaxy. Given both the very hard spectrum and the extended nature of the emission, it is highly unlikely that the haze electrons result from supernova shocks in the Galactic disk. Instead, a new astrophysical mechanism for cosmic-ray acceleration in the inner Galaxy is implied., European Space Agency, Centre National D'etudes Spatiales, CNRS/INSU-IN2P3-INP (France), Agenzia Spaziale Italiana (ASI), Italian National Research Council, Istituto Nazionale Astrofisica (INAF), National Aeronautics & Space Administration (NASA), United States Department of Energy (DOE), Science & Technology Facilities Council (STFC), UKSA (UK), Consejo Superior de Investigaciones Cientificas (CSIC), Spanish Government, JA (Spain), Finnish Funding Agency for Technology & Innovation (TEKES), AoF (Finland), CSC (Finland), Helmholtz Association German Aerospace Centre (DLR), Max Planck Society, CSA (Canada), DTU Space (Denmark), SER/SSO (Switzerland), RCN (Norway), Science Foundation Ireland, Portuguese Foundation for Science and Technology, European Union (EU), Harvey L. Karp Discovery Award, Science & Technology Facilities Council (STFC) ST/G003874/1 ST/J00152X/1 ST/J001562/1 ST/J004812/1 ST/I005765/1 ST/J001538/1 ST/K000985/1 ST/K003674/1 ST/L001314/1
Published: 2013

22. A Cacna1a Knockin Migraine Mouse Model with Increased Susceptibility to Cortical Spreading Depression

Author: Angelita Tottene, Tiziana Cesetti, Jos van der Kaa, Ludo A. M. Broos, Tommaso Pizzorusso, Jaap J. Plomp, Simon Kaja, Rune R. Frants, Arn M. J. M. van den Maagdenberg, Daniela Pietrobon, Rob C. G. van de Ven, Michel D. Ferrari, VAN DEN MAAGDENBERG, A. M. J. M., D., Pietrobon, Pizzorusso, T., S., Kaja, Broos, L. A. M., T., Cesetti, VAN DE VEN, R. C. G., A., Tottene, J., VAN DER KAA, Plomp, J. J., Frants, R. R., and Ferrari, M. D.
Subjects: Male, Aura, Neuroscience(all), Migraine with Aura, Mice, Transgenic, Neurotransmission, Motor Endplate, Calcium Channels, Q-Type, Mice, Calcium Channels, N-Type, ATP1A2, Animals, Humans, Medicine, Missense mutation, Genetic Predisposition to Disease, Cells, Cultured, Familial hemiplegic migraine, Recombination, Genetic, business.industry, General Neuroscience, Cortical Spreading Depression, Calcium Channels, P-Type, medicine.disease, Mice, Mutant Strains, Migraine with aura, Disease Models, Animal, Migraine, Cortical spreading depression, Mutation, Female, Calcium Channels, medicine.symptom, business, Neuroscience
Abstract: Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene that encodes the α 1 subunit of neuronal Ca v 2.1 Ca 2+ channels. We generated a knockin mouse model carrying the human pure FHM-1 R192Q mutation and found multiple gain-of-function effects. These include increased Ca v 2.1 current density in cerebellar neurons, enhanced neurotransmission at the neuromuscular junction, and, in the intact animal, a reduced threshold and increased velocity of cortical spreading depression (CSD; the likely mechanism for the migraine aura). Our data show that the increased susceptibility for CSD and aura in migraine may be due to cortical hyperexcitability. The R192Q FHM-1 mouse is a promising animal model to study migraine mechanisms and treatments.
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23. Astrocytic Na + , K + ATPases in physiology and pathophysiology.

Author: Pietrobon D and Conti F
Subjects: Humans, Mice, Animals, Sodium-Potassium-Exchanging ATPase genetics, Sodium-Potassium-Exchanging ATPase metabolism, Astrocytes metabolism, Migraine with Aura genetics, Migraine with Aura metabolism, Alzheimer Disease metabolism, Amyotrophic Lateral Sclerosis genetics, Amyotrophic Lateral Sclerosis metabolism
Abstract: The Na + , K + ATPases play a fundamental role in the homeostatic functions of astrocytes. After a brief historic prologue and discussion of the subunit composition and localization of the astrocytic Na + , K + ATPases, the review focuses on the role of the astrocytic Na + , K + pumps in extracellular K + and glutamate homeostasis, intracellular Na + and Ca 2+ homeostasis and signaling, regulation of synaptic transmission and neurometabolic coupling between astrocytes and neurons. Loss-of-function mutations in the gene encoding the astrocytic α2 Na + , K + ATPase cause a rare monogenic form of migraine with aura (familial hemiplegic migraine type 2). On the other hand, the α2 Na + , K + ATPase is upregulated in spinal cord and brain samples from amyotrophic lateral sclerosis and Alzheimer disease patients, respectively. In the last part, the review focuses on i) the migraine relevant phenotypes shown by familial hemiplegic migraine type 2 knock-in mice with 50 % reduced expression of the astrocytic α2 Na + , K + ATPase and the insights into the pathophysiology of migraine obtained from these genetic mouse models, and ii) the evidence that upregulation of the astrocytic α2 Na + , K + ATPase in mouse models of amyotrophic lateral sclerosis and Alzheimer disease promotes neuroinflammation and contributes to progressive neurodegeneration., Competing Interests: Declaration of competing interest None., (Copyright © 2024. Published by Elsevier Ltd.)
Published: 2024
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24. Correction: Mechanisms of initiation of cortical spreading depression.

Author: Vitale M, Tottene A, Zadeh MZ, Brennan KC, and Pietrobon D
Published: 2023
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25. Mechanisms of initiation of cortical spreading depression.

Author: Vitale M, Tottene A, Zarin Zadeh M, Brennan KC, and Pietrobon D
Subjects: Mice, Animals, Humans, Dizocilpine Maleate pharmacology, Receptors, N-Methyl-D-Aspartate, Cortical Spreading Depression physiology, Migraine Disorders, Migraine with Aura
Abstract: Background: There is increasing evidence from human and animal studies that cortical spreading depression (CSD) is the neurophysiological correlate of migraine aura and a trigger of migraine pain mechanisms. The mechanisms of initiation of CSD in the brain of migraineurs remain unknown, and the mechanisms of initiation of experimentally induced CSD in normally metabolizing brain tissue remain incompletely understood and controversial. Here, we investigated the mechanisms of CSD initiation by focal application of KCl in mouse cerebral cortex slices., Methods: High KCl puffs of increasing duration up to the threshold duration eliciting a CSD were applied on layer 2/3 whilst the membrane potential of a pyramidal neuron located very close to the site of KCl application and the intrinsic optic signal were simultaneously recorded. This was done before and after the application of a specific blocker of either NMDA or AMPA glutamate receptors (NMDARs, AMPARs) or voltage-gated Ca 2+ (Ca V ) channels. If the drug blocked CSD, stimuli up to 12-15 times the threshold were applied., Results: Blocking either NMDARs with MK-801 or Ca V channels with Ni 2+ completely inhibited CSD initiation by both CSD threshold and largely suprathreshold KCl stimuli. Inhibiting AMPARs with NBQX was without effect on the CSD threshold and velocity. Analysis of the CSD subthreshold and threshold neuronal depolarizations in control conditions and in the presence of MK-801 or Ni 2+ revealed that the mechanism underlying ignition of CSD by a threshold stimulus (and not by a just subthreshold stimulus) is the Ca V -dependent activation of a threshold level of NMDARs (and/or of channels whose opening depends on the latter). The delay of several seconds with which this occurs underlies the delay of CSD initiation relative to the rapid neuronal depolarization produced by KCl., Conclusions: Both NMDARs and Ca V channels are necessary for CSD initiation, which is not determined by the extracellular K + or neuronal depolarization levels per se, but requires the Ca V -dependent activation of a threshold level of NMDARs. This occurs with a delay of several seconds relative to the rapid depolarization produced by the KCl stimulus. Our data give insights into potential mechanisms of CSD initiation in migraine., (© 2023. Springer-Verlag Italia S.r.l., part of Springer Nature.)
Published: 2023
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26. Astrocytic Glutamate Transporters and Migraine.

Author: Conti F and Pietrobon D
Subjects: Mice, Animals, Astrocytes metabolism, Sodium-Potassium-Exchanging ATPase metabolism, Glutamic Acid metabolism, Migraine Disorders metabolism, Migraine with Aura genetics
Abstract: Glutamate levels and lifetime in the brain extracellular space are dinamically regulated by a family of Na + - and K + -dependent glutamate transporters, which thereby control numerous brain functions and play a role in numerous neurological and psychiatric diseases. Migraine is a neurological disorder characterized by recurrent attacks of typically throbbing and unilateral headache and by a global dysfunction in multisensory processing. Familial hemiplegic migraine type 2 (FHM2) is a rare monogenic form of migraine with aura caused by loss-of-function mutations in the α2 Na/K ATPase (α2NKA). In the adult brain, this pump is expressed almost exclusively in astrocytes where it is colocalized with glutamate transporters. Knockin mouse models of FHM2 (FHM2 mice) show a reduced density of glutamate transporters in perisynaptic astrocytic processes (mirroring the reduced expression of α2NKA) and a reduced rate of glutamate clearance at cortical synapses during neuronal activity and sensory stimulation. Here we review the migraine-relevant alterations produced by the astrocytic glutamate transport dysfunction in FHM2 mice and their underlying mechanisms, in particular regarding the enhanced brain susceptibility to cortical spreading depression (the phenomenon that underlies migraine aura and can also initiate the headache mechanisms) and the enhanced algesic response to a migraine trigger., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Published: 2023
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27. Synaptic alterations in visual cortex reshape contrast-dependent gamma oscillations and inhibition-excitation ratio in a genetic mouse model of migraine.

Author: Meneghetti N, Cerri C, Vannini E, Tantillo E, Tottene A, Pietrobon D, Caleo M, and Mazzoni A
Subjects: Animals, Disease Models, Animal, Evoked Potentials, Visual, Mice, Migraine Disorders genetics, Migraine with Aura, Visual Cortex
Abstract: Background: Migraine affects a significant fraction of the world population, yet its etiology is not completely understood. In vitro results highlighted thalamocortical and intra-cortical glutamatergic synaptic gain-of-function associated with a monogenic form of migraine (familial-hemiplegic-migraine-type-1: FHM1). However, how these alterations reverberate on cortical activity remains unclear. As altered responsivity to visual stimuli and abnormal processing of visual sensory information are common hallmarks of migraine, herein we investigated the effects of FHM1-driven synaptic alterations in the visual cortex of awake mice., Methods: We recorded extracellular field potentials from the primary visual cortex (V1) of head-fixed awake FHM1 knock-in (n = 12) and wild type (n = 12) mice in response to square-wave gratings with different visual contrasts. Additionally, we reproduced in silico the obtained experimental results with a novel spiking neurons network model of mouse V1, by implementing in the model both the synaptic alterations characterizing the FHM1 genetic mouse model adopted., Results: FHM1 mice displayed similar amplitude but slower temporal evolution of visual evoked potentials. Visual contrast stimuli induced a lower increase of multi-unit activity in FHM1 mice, while the amount of information content about contrast level remained, however, similar to WT. Spectral analysis of the local field potentials revealed an increase in the β/low γ range of WT mice following the abrupt reversal of contrast gratings. Such frequency range transitioned to the high γ range in FHM1 mice. Despite this change in the encoding channel, these oscillations preserved the amount of information conveyed about visual contrast. The computational model showed how these network effects may arise from a combination of changes in thalamocortical and intra-cortical synaptic transmission, with the former inducing a lower cortical activity and the latter inducing the higher frequencies ɣ oscillations., Conclusions: Contrast-driven ɣ modulation in V1 activity occurs at a much higher frequency in FHM1. This is likely to play a role in the altered processing of visual information. Computational studies suggest that this shift is specifically due to enhanced cortical excitatory transmission. Our network model can help to shed light on the relationship between cellular and network levels of migraine neural alterations., (© 2022. The Author(s).)
Published: 2022
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28. Enhanced Feedback Inhibition Due to Increased Recruitment of Somatostatin-Expressing Interneurons and Enhanced Cortical Recurrent Excitation in a Genetic Mouse Model of Migraine.

Author: Marchionni I, Pilati N, Forli A, Sessolo M, Tottene A, and Pietrobon D
Abstract: Migraine is a complex brain disorder, characterized by attacks of unilateral headache and global dysfunction in multisensory information processing, whose underlying cellular and circuit mechanisms remain unknown. The finding of enhanced excitatory, but unaltered inhibitory, neurotransmission at cortical synapses between pyramidal cells (PCs) and fast-spiking interneurons (FS INs) in mouse models of familial hemiplegic migraine (FHM) suggested the hypothesis that dysregulation of the excitatory-inhibitory (E/I) balance in specific circuits is a key pathogenic mechanism. Here, we investigated the cortical layer 2/3 (L2/3) feedback inhibition microcircuit involving somatostatin-expressing (SOM) INs in FHM1 mice of both sexes carrying a gain-of-function mutation in Ca V 2.1. Unitary inhibitory neurotransmission at SOM IN-PC synapses was unaltered while excitatory neurotransmission at both PC-SOM IN and PC-PC synapses was enhanced, because of increased probability of glutamate release, in FHM1 mice. Short-term synaptic depression was enhanced at PC-PC synapses while short-term synaptic facilitation was unaltered at PC-SOM IN synapses during 25-Hz repetitive activity. The frequency-dependent disynaptic inhibition (FDDI) mediated by SOM INs was enhanced, lasted longer and required shorter high-frequency bursts to be initiated in FHM1 mice. These findings, together with previous evidence of enhanced disynaptic feedforward inhibition by FS INs, suggest that the increased inhibition may effectively counteract the increased recurrent excitation in FHM1 mice and may even prevail in certain conditions. Considering the involvement of SOM INs in γ oscillations, surround suppression and context-dependent sensory perception, the facilitated recruitment of SOM INs, together with the enhanced recurrent excitation, may contribute to dysfunctional sensory processing in FHM1 and possibly migraine. SIGNIFICANCE STATEMENT Migraine is a complex brain disorder, characterized by attacks of unilateral headache and global dysfunction in multisensory information processing, whose underlying cellular and circuit mechanisms remain unknown, although dysregulation of the excitatory-inhibitory (E/I) balance in specific circuits could be a key pathogenic mechanism. Here, we provide insights into these mechanisms by investigating the cortical feedback inhibition microcircuit involving somatostatin-expressing interneurons (SOM INs) in a mouse model of a rare monogenic migraine. Despite unaltered inhibitory synaptic transmission, the disynaptic feedback inhibition mediated by SOM INs was enhanced in the migraine model because of enhanced recruitment of the INs. Recurrent cortical excitation was also enhanced. These alterations may contribute to context-dependent sensory processing dysfunctions in migraine., (Copyright © 2022 Marchionni, Pilati et al.)
Published: 2022
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29. Specific activation of GluN1-N2B NMDA receptors underlies facilitation of cortical spreading depression in a genetic mouse model of migraine with reduced astrocytic glutamate clearance.

Author: Crivellaro G, Tottene A, Vitale M, Melone M, Casari G, Conti F, Santello M, and Pietrobon D
Subjects: Animals, Extracellular Space metabolism, Female, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Migraine Disorders genetics, Nerve Tissue Proteins genetics, Organ Culture Techniques, Receptors, N-Methyl-D-Aspartate genetics, Somatosensory Cortex metabolism, Astrocytes metabolism, Cortical Spreading Depression physiology, Glutamic Acid metabolism, Migraine Disorders metabolism, Nerve Tissue Proteins metabolism, Receptors, N-Methyl-D-Aspartate metabolism
Abstract: Migraine is a common but poorly understood sensory circuit disorder. Mouse models of familial hemiplegic migraine (FHM, a rare monogenic form of migraine with aura) show increased susceptibility to cortical spreading depression (CSD, the phenomenon that underlies migraine aura and can activate migraine headache mechanisms), allowing an opportunity to investigate the mechanisms of CSD and migraine onset. In FHM type 2 (FHM2) knock-in mice with reduced expression of astrocytic Na + , K + -ATPases, the reduced rate of glutamate uptake into astrocytes can account for the facilitation of CSD initiation. Here, we investigated the underlying mechanisms and show that the reduced rate of glutamate clearance in FHM2 mice results in increased amplitude and slowing of rise time and decay of the NMDA receptor (NMDAR) excitatory postsynaptic current (EPSC) elicited in layer 2/3 pyramidal cells by stimulation of neuronal afferents in somatosensory cortex slices. The relative increase in NMDAR activation in FHM2 mice is activity-dependent, being larger after high-frequency compared to low-frequency afferent activity. Inhibition of GluN1-N2B NMDARs, which hardly affected the NMDAR EPSC in wild-type mice, rescued the increased and prolonged activation of NMDARs as well as the facilitation of CSD induction and propagation in FHM2 mice. Our data suggest that the enhanced susceptibility to CSD in FHM2 is mainly due to specific activation of extrasynaptic GluN1-N2B NMDARs and point to these receptors as possible therapeutic targets for prevention of CSD and migraine., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2021
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30. Non-canonical glutamate signaling in a genetic model of migraine with aura.

Author: Parker PD, Suryavanshi P, Melone M, Sawant-Pokam PA, Reinhart KM, Kaufmann D, Theriot JJ, Pugliese A, Conti F, Shuttleworth CW, Pietrobon D, and Brennan KC
Subjects: Animals, Female, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Organ Culture Techniques, Brain metabolism, Glutamic Acid metabolism, Migraine with Aura genetics, Migraine with Aura metabolism, Models, Genetic, Signal Transduction physiology
Abstract: Migraine with aura is a common but poorly understood sensory circuit disorder. Monogenic models allow an opportunity to investigate its mechanisms, including spreading depolarization (SD), the phenomenon underlying migraine aura. Using fluorescent glutamate imaging, we show that awake mice carrying a familial hemiplegic migraine type 2 (FHM2) mutation have slower clearance during sensory processing, as well as previously undescribed spontaneous "plumes" of glutamate. Glutamatergic plumes overlapped anatomically with a reduced density of GLT-1a-positive astrocyte processes and were mimicked in wild-type animals by inhibiting glutamate clearance. Plume pharmacology and plume-like neural Ca 2+ events were consistent with action-potential-independent spontaneous glutamate release, suggesting plumes are a consequence of inefficient clearance following synaptic release. Importantly, a rise in basal glutamate and plume frequency predicted the onset of SD in both FHM2 and wild-type mice, providing a novel mechanism in migraine with aura and, by extension, the other neurological disorders where SD occurs., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2021
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31. Diagnostic and therapeutic aspects of hemiplegic migraine.

Author: Di Stefano V, Rispoli MG, Pellegrino N, Graziosi A, Rotondo E, Napoli C, Pietrobon D, Brighina F, and Parisi P
Subjects: Calcium Channels genetics, Diagnosis, Differential, Humans, Migraine with Aura genetics, Migraine with Aura physiopathology, Mutation, Pedigree, Disease Management, Migraine with Aura diagnosis
Abstract: Hemiplegic migraine (HM) is a clinically and genetically heterogeneous condition with attacks of headache and motor weakness which may be associated with impaired consciousness, cerebellar ataxia and intellectual disability. Motor symptoms usually last <72 hours and are associated with visual or sensory manifestations, speech impairment or brainstem aura. HM can occur as a sporadic HM or familiar HM with an autosomal dominant mode of inheritance. Mutations in CACNA1A, ATP1A2 and SCN1A encoding proteins involved in ion transport are implicated. The pathophysiology of HM is close to the process of typical migraine with aura, but appearing with a lower threshold and more severity. We reviewed epidemiology, clinical presentation, diagnostic assessment, differential diagnosis and treatment of HM to offer the best evidence of this rare condition. The differential diagnosis of HM is broad, including other types of migraine and any condition that can cause transitory neurological signs and symptoms. Neuroimaging, cerebrospinal fluid analysis and electroencephalography are useful, but the diagnosis is clinical with a genetic confirmation. The management relies on the control of triggering factors and even hospitalisation in case of long-lasting auras. As HM is a rare condition, there are no randomised controlled trials, but the evidence for the treatment comes from small studies., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2020
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32. Astrocyte dysfunction increases cortical dendritic excitability and promotes cranial pain in familial migraine.

Author: Romanos J, Benke D, Pietrobon D, Zeilhofer HU, and Santello M
Subjects: Animals, Disease Models, Animal, Glutamic Acid metabolism, Headache metabolism, Mice, N-Methylaspartate metabolism, Astrocytes metabolism, Migraine Disorders genetics, Migraine Disorders metabolism
Abstract: Astrocytes are essential contributors to neuronal function. As a consequence, disturbed astrocyte-neuron interactions are involved in the pathophysiology of several neurological disorders, with a strong impact on brain circuits and behavior. Here, we describe altered cortical physiology in a genetic mouse model of familial hemiplegic migraine type 2 (FHM2), with reduced expression of astrocytic Na + ,K + -ATPases. We used whole-cell electrophysiology, two-photon microscopy, and astrocyte gene rescue to demonstrate that an impairment in astrocytic glutamate uptake promotes NMDA spike generation in dendrites of cingulate cortex pyramidal neurons and enhances output firing of these neurons. Astrocyte compensation of the defective ATPase in the cingulate cortex rescued glutamate uptake, prevented abnormal NMDA spikes, and reduced sensitivity to cranial pain triggers. Together, our results demonstrate that impaired astrocyte function alters neuronal activity in the cingulate cortex and facilitates migraine-like cranial pain states in a mouse model of migraine., (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).)
Published: 2020
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33. Enhanced Thalamocortical Synaptic Transmission and Dysregulation of the Excitatory-Inhibitory Balance at the Thalamocortical Feedforward Inhibitory Microcircuit in a Genetic Mouse Model of Migraine.

Author: Tottene A, Favero M, and Pietrobon D
Subjects: Animals, Calcium Channels, N-Type genetics, Disease Models, Animal, Excitatory Postsynaptic Potentials, Mice, Mice, Inbred C57BL, Mice, Transgenic, Migraine with Aura genetics, Mutation, Neural Inhibition, Nociception, Patch-Clamp Techniques, Signal Transduction, Trigeminal Nerve physiopathology, Cerebral Cortex physiopathology, Feedback, Physiological, Migraine with Aura physiopathology, Neural Pathways physiopathology, Synaptic Transmission, Thalamus physiopathology
Abstract: Migraine is a complex brain disorder, characterized by attacks of unilateral headache and global dysfunction in multisensory information processing, whose underlying cellular and circuit mechanisms remain unknown. The finding of enhanced excitatory, but unaltered inhibitory, neurotransmission at intracortical synapses in mouse models of familial hemiplegic migraine (FHM) suggested the hypothesis that dysregulation of the excitatory-inhibitory balance in specific circuits is a key pathogenic mechanism. Here, we investigated the thalamocortical (TC) feedforward inhibitory microcircuit in FHM1 mice of both sexes carrying a gain-of-function mutation in Ca V 2.1. We show that TC synaptic transmission in somatosensory cortex is enhanced in FHM1 mice. Due to similar gain of function of TC excitation of layer 4 excitatory and fast-spiking inhibitory neurons elicited by single thalamic stimulations, neither the excitatory-inhibitory balance nor the integration time window set by the TC feedforward inhibitory microcircuit was altered in FHM1 mice. However, during repetitive thalamic stimulation, the typical shift of the excitatory-inhibitory balance toward excitation and the widening of the integration time window were both smaller in FHM1 compared with WT mice, revealing a dysregulation of the excitatory-inhibitory balance, whereby the balance is relatively skewed toward inhibition. This is due to an unexpected differential effect of the FHM1 mutation on short-term synaptic plasticity at TC synapses on cortical excitatory and fast-spiking inhibitory neurons. Our findings point to enhanced transmission of sensory, including trigeminovascular nociceptive, signals from thalamic nuclei to cortex and TC excitatory-inhibitory imbalance as mechanisms that may contribute to headache, increased sensory gain, and sensory processing dysfunctions in migraine. SIGNIFICANCE STATEMENT Migraine is a complex brain disorder, characterized by attacks of unilateral headache and by global dysfunction in multisensory information processing, whose underlying cellular and circuit mechanisms remain unknown. Here we provide insights into these mechanisms by investigating thalamocortical (TC) synaptic transmission and the function of the TC feedforward inhibitory microcircuit in a mouse model of a rare monogenic migraine. This microcircuit is critical for gating information flow to cortex and for sensory processing. We reveal increased TC transmission and dysregulation of the cortical excitatory-inhibitory balance set by the TC feedforward inhibitory microcircuit, whereby the balance is relatively skewed toward inhibition during repetitive thalamic activity. These alterations may contribute to headache, increased sensory gain, and sensory processing dysfunctions in migraine., (Copyright © 2019 the authors.)
Published: 2019
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34. Differential effect of FHM2 mutation on synaptic plasticity in distinct hippocampal regions.

Author: Iure A, Mazzocchetti P, Bastioli G, Picconi B, Costa C, Marchionni I, Casari G, Tozzi A, Pietrobon D, and Calabresi P
Subjects: Animals, Mice, Migraine with Aura genetics, Mutation, Sodium-Potassium-Exchanging ATPase genetics, Hippocampus physiopathology, Long-Term Potentiation physiology, Migraine with Aura physiopathology, Synaptic Transmission physiology
Abstract: Introduction: Familial hemiplegic migraine 2 is a pathology linked to mutation of the ATP1A2 gene producing loss of function of the α2 Na + /K + -ATPase (NKA). W887R/+ knock-in (KI) mice are used to model the familial hemiplegic migraine 2 condition and are characterized by 50% reduced NKA expression in the brain and reduced rate of K + and glutamate clearance by astrocytes. These alterations might, in turn, produce synaptic changes in synaptic transmission and plasticity. Memory and learning deficits observed in familial hemiplegic migraine patients could be ascribed to a possible alteration of hippocampal neuronal plasticity and measuring possible changes of long-term potentiation in familial hemiplegic migraine 2 KI mice might provide insights to strengthen this link., Results: Here we have investigated synaptic plasticity in distinct hippocampal regions in familial hemiplegic migraine 2 KI mice. We show that the dentate gyrus long-term potentiation of familial hemiplegic migraine 2 mice is abnormally increased in comparison with control animals. Conversely, in the CA1 area, KI and WT mice express long-term potentiation of similar amplitude., Conclusions: The familial hemiplegic migraine 2 KI mice show region-dependent hippocampal plasticity abnormality, which might underlie some of the memory deficits observed in familial migraine.
Published: 2019
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35. Heterogeneity of Astrocytic and Neuronal GLT-1 at Cortical Excitatory Synapses, as Revealed by its Colocalization With Na+/K+-ATPase α Isoforms.

Author: Melone M, Ciriachi C, Pietrobon D, and Conti F
Subjects: Animals, Blotting, Western, Cell Surface Extensions metabolism, Cerebral Cortex cytology, Cerebral Cortex metabolism, Dendrites metabolism, Immunohistochemistry, Mice, Presynaptic Terminals metabolism, Rats, Rats, Sprague-Dawley, Vesicular Glutamate Transport Protein 1 metabolism, Astrocytes metabolism, Excitatory Amino Acid Transporter 2 metabolism, Neurons metabolism, Sodium-Potassium-Exchanging ATPase metabolism, Synapses metabolism
Abstract: GLT-1, the major glutamate transporter, is expressed at perisynaptic astrocytic processes (PAP) and axon terminals (AxT). GLT-1 is coupled to Na+/K+-ATPase (NKA) α1-3 isoforms, whose subcellular distribution and spatial organization in relationship to GLT-1 are largely unknown. Using several microscopy techniques, we showed that at excitatory synapses α1 and α3 are exclusively neuronal (mainly in dendrites and in some AxT), while α2 is predominantly astrocytic. GLT-1 displayed a differential colocalization with α1-3. GLT-1/α2 and GLT-1/α3 colocalization was higher in GLT-1 positive puncta partially (for GLT-1/α2) or almost totally (for GLT-1/α3) overlapping with VGLUT1 positive terminals than in nonoverlapping ones. GLT-1 colocalized with α2 at PAP, and with α1 and α3 at AxT. GLT-1 and α2 gold particles were ∼1.5-2 times closer than GLT-1/α1 and GLT-1/α3 particles. GLT-1/α2 complexes (edge to edge interdistance of gold particles ≤50 nm) concentrated at the perisynaptic region of PAP membranes, whereas neuronal GLT-1/α1 and GLT-1/α3 complexes were fewer and more uniformly distributed in AxT. These data unveil different composition of GLT-1 and α subunits complexes in the glial and neuronal domains of excitatory synapses. The spatial organization of GLT-1/α1-3 complexes suggests that GLT-1/NKA interaction is more efficient in astrocytes than in neurons, further supporting the dominant role of astrocytic GLT-1 in glutamate homeostasis., (© The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
Published: 2019
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36. Genetic mouse models of migraine.

Author: Pietrobon D and Brennan KC
Subjects: Animals, Cerebral Cortex physiopathology, Humans, Mice, Migraine Disorders metabolism, Neurons metabolism, Neurons pathology, Disease Models, Animal, Migraine Disorders genetics, Migraine Disorders physiopathology
Abstract: Mouse models of rare monogenic forms of migraine provide a unique experimental system to study the cellular and circuit mechanisms of the primary brain dysfunctions causing a migraine disorder. Here, we discuss the migraine-relevant phenotypes and the migraine-relevant functional alterations in the brain of five genetic mouse models of migraine, four of which carry mutations derived from patients with familial hemiplegic migraine (FHM) and the fifth carry a mutation from patients with both phenotypically normal MA and familial advanced sleep phase syndrome (FASPS). We focus on the latter mouse model, in which a ubiquitous serine-threonine kinase is mutated, and on two mouse models of pure FHM, in which a voltage-gated calcium channel controlling neurotransmitter release at most brain synapses and a Na/K ATPase that is expressed mainly in astrocytes in the adult brain are mutated, respectively. First, we describe the behavioral phenotypes of the genetic animal models and review the evidence that an increased susceptibility to experimentally induced cortical spreading depression (CSD) is a key migraine-relevant phenotype common to the five models. Second, we review the synaptic alterations in the cerebral cortex of the genetic models of migraine and discuss the mechanisms underlying their increased susceptibility to CSD. Third, we review the alterations in the trigeminovascular pain pathway and discuss possible implications for migraine pain mechanisms. Finally, we discuss the insights into migraine pathophysiology obtained from the genetic models of migraine, in particular regarding the mechanisms that make the brain of migraineurs susceptible to the ignition of "spontaneous" CSDs. Although the reviewed functional studies support the view of migraine as a disorder of the brain characterized by dysfunctional regulation of the excitatory/inhibitory balance in specific neuronal circuits, much work remains to be done in the genetic mouse models e.g. to identfy the relevant dysfunctional circuits and to establish whether and how the alterations in the function of specific circuits (in the cerebral cortex and/or other brain areas) are state-dependent and may, in certain conditions, favor CSD ignition and the migraine attack.
Published: 2019
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37. A Systems Neuroscience Approach to Migraine.

Author: Brennan KC and Pietrobon D
Subjects: Animals, Humans, Migraine Disorders therapy, Nerve Net physiopathology, Neurosciences methods, Psychomotor Performance physiology, Brain physiopathology, Cortical Spreading Depression physiology, Migraine Disorders physiopathology, Neuronal Plasticity physiology, Neurosciences trends, Systems Analysis
Abstract: Migraine is an extremely common but poorly understood nervous system disorder. We conceptualize migraine as a disorder of sensory network gain and plasticity, and we propose that this framing makes it amenable to the tools of current systems neuroscience., (Copyright © 2018 Elsevier Inc. All rights reserved.)
Published: 2018
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38. Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2.

Author: Capuani C, Melone M, Tottene A, Bragina L, Crivellaro G, Santello M, Casari G, Conti F, and Pietrobon D
Subjects: Animals, Disease Models, Animal, Gene Knock-In Techniques, Mice, Astrocytes metabolism, Cerebral Cortex pathology, Cerebral Cortex physiopathology, Glutamic Acid metabolism, Migraine with Aura pathology, Migraine with Aura physiopathology, Potassium metabolism
Abstract: Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial hemiplegic migraine type 2: FHM2) is caused by loss-of-function mutations in α2 Na(+),K(+) ATPase (α2 NKA), an isoform almost exclusively expressed in astrocytes in adult brain. Cortical spreading depression (CSD), the phenomenon that underlies migraine aura and activates migraine headache mechanisms, is facilitated in heterozygous FHM2-knockin mice with reduced expression of α2 NKA The mechanisms underlying an increased susceptibility to CSD in FHM2 are unknown. Here, we show reduced rates of glutamate and K(+) clearance by cortical astrocytes during neuronal activity and reduced density of GLT-1a glutamate transporters in cortical perisynaptic astrocytic processes in heterozygous FHM2-knockin mice, demonstrating key physiological roles of α2 NKA and supporting tight coupling with GLT-1a. Using ceftriaxone treatment of FHM2 mutants and partial inhibition of glutamate transporters in wild-type mice, we obtain evidence that defective glutamate clearance can account for most of the facilitation of CSD initiation in FHM2-knockin mice, pointing to excessive glutamatergic transmission as a key mechanism underlying the vulnerability to CSD ignition in migraine., (© 2016 The Authors. Published under the terms of the CC BY 4.0 license.)
Published: 2016
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39. Cortical spreading depression and familial hemiplegic migraine 2015.

Author: Pietrobon D
Published: 2015
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40. Joint analysis of BICEP2/keck array and Planck Data.

Author: Ade PA, Aghanim N, Ahmed Z, Aikin RW, Alexander KD, Arnaud M, Aumont J, Baccigalupi C, Banday AJ, Barkats D, Barreiro RB, Bartlett JG, Bartolo N, Battaner E, Benabed K, Benoît A, Benoit-Lévy A, Benton SJ, Bernard JP, Bersanelli M, Bielewicz P, Bischoff CA, Bock JJ, Bonaldi A, Bonavera L, Bond JR, Borrill J, Bouchet FR, Boulanger F, Brevik JA, Bucher M, Buder I, Bullock E, Burigana C, Butler RC, Buza V, Calabrese E, Cardoso JF, Catalano A, Challinor A, Chary RR, Chiang HC, Christensen PR, Colombo LP, Combet C, Connors J, Couchot F, Coulais A, Crill BP, Curto A, Cuttaia F, Danese L, Davies RD, Davis RJ, de Bernardis P, de Rosa A, de Zotti G, Delabrouille J, Delouis JM, Désert FX, Dickinson C, Diego JM, Dole H, Donzelli S, Doré O, Douspis M, Dowell CD, Duband L, Ducout A, Dunkley J, Dupac X, Dvorkin C, Efstathiou G, Elsner F, Enßlin TA, Eriksen HK, Falgarone E, Filippini JP, Finelli F, Fliescher S, Forni O, Frailis M, Fraisse AA, Franceschi E, Frejsel A, Galeotta S, Galli S, Ganga K, Ghosh T, Giard M, Gjerløw E, Golwala SR, González-Nuevo J, Górski KM, Gratton S, Gregorio A, Gruppuso A, Gudmundsson JE, Halpern M, Hansen FK, Hanson D, Harrison DL, Hasselfield M, Helou G, Henrot-Versillé S, Herranz D, Hildebrandt SR, Hilton GC, Hivon E, Hobson M, Holmes WA, Hovest W, Hristov VV, Huffenberger KM, Hui H, Hurier G, Irwin KD, Jaffe AH, Jaffe TR, Jewell J, Jones WC, Juvela M, Karakci A, Karkare KS, Kaufman JP, Keating BG, Kefeli S, Keihänen E, Kernasovskiy SA, Keskitalo R, Kisner TS, Kneissl R, Knoche J, Knox L, Kovac JM, Krachmalnicoff N, Kunz M, Kuo CL, Kurki-Suonio H, Lagache G, Lähteenmäki A, Lamarre JM, Lasenby A, Lattanzi M, Lawrence CR, Leitch EM, Leonardi R, Levrier F, Lewis A, Liguori M, Lilje PB, Linden-Vørnle M, López-Caniego M, Lubin PM, Lueker M, Macías-Pérez JF, Maffei B, Maino D, Mandolesi N, Mangilli A, Maris M, Martin PG, Martínez-González E, Masi S, Mason P, Matarrese S, Megerian KG, Meinhold PR, Melchiorri A, Mendes L, Mennella A, Migliaccio M, Mitra S, Miville-Deschênes MA, Moneti A, Montier L, Morgante G, Mortlock D, Moss A, Munshi D, Murphy JA, Naselsky P, Nati F, Natoli P, Netterfield CB, Nguyen HT, Nørgaard-Nielsen HU, Noviello F, Novikov D, Novikov I, O'Brient R, Ogburn RW, Orlando A, Pagano L, Pajot F, Paladini R, Paoletti D, Partridge B, Pasian F, Patanchon G, Pearson TJ, Perdereau O, Perotto L, Pettorino V, Piacentini F, Piat M, Pietrobon D, Plaszczynski S, Pointecouteau E, Polenta G, Ponthieu N, Pratt GW, Prunet S, Pryke C, Puget JL, Rachen JP, Reach WT, Rebolo R, Reinecke M, Remazeilles M, Renault C, Renzi A, Richter S, Ristorcelli I, Rocha G, Rossetti M, Roudier G, Rowan-Robinson M, Rubiño-Martín JA, Rusholme B, Sandri M, Santos D, Savelainen M, Savini G, Schwarz R, Scott D, Seiffert MD, Sheehy CD, Spencer LD, Staniszewski ZK, Stolyarov V, Sudiwala R, Sunyaev R, Sutton D, Suur-Uski AS, Sygnet JF, Tauber JA, Teply GP, Terenzi L, Thompson KL, Toffolatti L, Tolan JE, Tomasi M, Tristram M, Tucci M, Turner AD, Valenziano L, Valiviita J, Van Tent B, Vibert L, Vielva P, Vieregg AG, Villa F, Wade LA, Wandelt BD, Watson R, Weber AC, Wehus IK, White M, White SD, Willmert J, Wong CL, Yoon KW, Yvon D, Zacchei A, and Zonca A
Abstract: We report the results of a joint analysis of data from BICEP2/Keck Array and Planck. BICEP2 and Keck Array have observed the same approximately 400 deg^{2} patch of sky centered on RA 0 h, Dec. -57.5°. The combined maps reach a depth of 57 nK deg in Stokes Q and U in a band centered at 150 GHz. Planck has observed the full sky in polarization at seven frequencies from 30 to 353 GHz, but much less deeply in any given region (1.2 μK deg in Q and U at 143 GHz). We detect 150×353 cross-correlation in B modes at high significance. We fit the single- and cross-frequency power spectra at frequencies ≥150 GHz to a lensed-ΛCDM model that includes dust and a possible contribution from inflationary gravitational waves (as parametrized by the tensor-to-scalar ratio r), using a prior on the frequency spectral behavior of polarized dust emission from previous Planck analysis of other regions of the sky. We find strong evidence for dust and no statistically significant evidence for tensor modes. We probe various model variations and extensions, including adding a synchrotron component in combination with lower frequency data, and find that these make little difference to the r constraint. Finally, we present an alternative analysis which is similar to a map-based cleaning of the dust contribution, and show that this gives similar constraints. The final result is expressed as a likelihood curve for r, and yields an upper limit r_{0.05}<0.12 at 95% confidence. Marginalizing over dust and r, lensing B modes are detected at 7.0σ significance.
Published: 2015
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41. Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans.

Author: Vecchia D, Tottene A, van den Maagdenberg AM, and Pietrobon D
Abstract: Familial hemiplegic migraine type 1 (FHM1) is caused by gain-of-function mutations in CaV2.1 (P/Q-type) Ca(2+) channels. Knockin (KI) mice carrying the FHM1 R192Q missense mutation show enhanced cortical excitatory synaptic transmission at pyramidal cell synapses but unaltered cortical inhibitory neurotransmission at fast-spiking interneuron synapses. Enhanced cortical glutamate release was shown to cause the facilitation of cortical spreading depression (CSD) in R192Q KI mice. It, however, remains unknown how other FHM1 mutations affect cortical synaptic transmission. Here, we studied neurotransmission in cortical neurons in microculture from KI mice carrying the S218L mutation, which causes a severe FHM syndrome in humans and an allele-dosage dependent facilitation of experimental CSD in KI mice, which is larger than that caused by the R192Q mutation. We show gain-of-function of excitatory neurotransmission, due to increased action-potential evoked Ca(2+) influx and increased probability of glutamate release at pyramidal cell synapses, but unaltered inhibitory neurotransmission at multipolar interneuron synapses in S218L KI mice. In contrast with the larger gain-of-function of neuronal CaV2.1 current in homozygous than heterozygous S218L KI mice, the gain-of-function of evoked glutamate release, the paired-pulse ratio and the Ca(2+) dependence of the excitatory postsynaptic current were similar in homozygous and heterozygous S218L KI mice, suggesting compensatory changes in the homozygous mice. Furthermore, we reveal a unique feature of S218L KI cortical synapses which is the presence of a fraction of mutant CaV2.1 channels being open at resting potential. Our data suggest that, while the gain-of-function of evoked glutamate release may explain the facilitation of CSD in heterozygous S218L KI mice, the further facilitation of CSD in homozygous S218L KI mice is due to other CaV2.1-dependent mechanisms, that likely include Ca(2+) influx at voltages sub-threshold for action potential generation.
Published: 2015
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42. Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice.

Author: Vecchia D, Tottene A, van den Maagdenberg AM, and Pietrobon D
Subjects: Action Potentials drug effects, Action Potentials physiology, Animals, Calcium metabolism, Calcium Channels genetics, Calcium Channels, N-Type genetics, Cell Culture Techniques, Cerebral Cortex drug effects, Disease Models, Animal, Gene Knock-In Techniques, Humans, Inhibitory Postsynaptic Potentials drug effects, Inhibitory Postsynaptic Potentials physiology, Interneurons drug effects, Interneurons physiology, Mice, Inbred C57BL, Mice, Transgenic, Migraine with Aura genetics, Mutation, Neural Inhibition drug effects, Presynaptic Terminals physiology, Pyramidal Cells drug effects, Pyramidal Cells physiopathology, Synaptic Transmission drug effects, gamma-Aminobutyric Acid metabolism, Calcium Channels metabolism, Calcium Channels, N-Type metabolism, Cerebral Cortex physiopathology, Migraine with Aura physiopathology, Neural Inhibition physiology, Synaptic Transmission physiology
Abstract: Familial hemiplegic migraine type 1 (FHM1), a monogenic subtype of migraine with aura, is caused by gain-of-function mutations in CaV2.1 (P/Q-type) calcium channels. In FHM1 knockin mice, excitatory neurotransmission at cortical pyramidal cell synapses is enhanced, but inhibitory neurotransmission at connected pairs of fast-spiking (FS) interneurons and pyramidal cells is unaltered, despite being initiated by CaV2.1 channels. The mechanism underlying the unaltered GABA release at cortical FS interneuron synapses remains unknown. Here, we show that the FHM1 R192Q mutation does not affect inhibitory transmission at autapses of cortical FS and other types of multipolar interneurons in microculture from R192Q knockin mice, and investigate the underlying mechanism. Lowering the extracellular [Ca(2+)] did not reveal gain-of-function of evoked transmission neither in control nor after prolongation of the action potential (AP) with tetraethylammonium, indicating unaltered AP-evoked presynaptic calcium influx at inhibitory autapses in FHM1 KI mice. Neither saturation of the presynaptic calcium sensor nor short duration of the AP can explain the unaltered inhibitory transmission in the mutant mice. Recordings of the P/Q-type calcium current in multipolar interneurons in microculture revealed that the current density and the gating properties of the CaV2.1 channels expressed in these interneurons are barely affected by the FHM1 mutation, in contrast with the enhanced current density and left-shifted activation gating of mutant CaV2.1 channels in cortical pyramidal cells. Our findings suggest that expression of specific CaV2.1 channels differentially sensitive to modulation by FHM1 mutations in inhibitory and excitatory cortical neurons underlies the gain-of-function of excitatory but unaltered inhibitory synaptic transmission and the likely consequent dysregulation of the cortical excitatory-inhibitory balance in FHM1., (Copyright © 2014. Published by Elsevier Inc.)
Published: 2014
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43. Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations.

Author: Pietrobon D and Moskowitz MA
Subjects: Animals, Brain Injuries pathology, Cerebral Cortex cytology, Cerebral Cortex metabolism, Cortical Spreading Depression genetics, Humans, Migraine Disorders pathology, Brain Injuries physiopathology, Cerebral Cortex physiopathology, Cortical Spreading Depression physiology, Migraine Disorders physiopathology
Abstract: Punctuated episodes of spreading depolarizations erupt in the brain, encumbering tissue structure and function, and raising fascinating unanswered questions concerning their initiation and propagation. Linked to migraine aura and headache, cortical spreading depression contributes to the morbidity in the world's migraine with aura population. Even more ominously, erupting spreading depolarizations accelerate tissue damage during brain injury. The once-held view that spreading depolarizations may not exist in the human brain has changed, largely because of the discovery of migraine genes that confer cortical spreading depression susceptibility, the application of sophisticated imaging tools and efforts to interrogate their impact in the acutely injured human brain.
Published: 2014
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44. Calcium channels and migraine.

Author: Pietrobon D
Subjects: Animals, Humans, Mice, Calcium metabolism, Calcium Channels physiology, Migraine Disorders physiopathology
Abstract: Missense mutations in CACNA1A, the gene that encodes the pore-forming α1 subunit of human voltage-gated Ca(V)2.1 (P/Q-type) calcium channels, cause a rare form of migraine with aura (familial hemiplegic migraine type 1: FHM1). Migraine is a common disabling brain disorder whose key manifestations are recurrent attacks of unilateral headache that may be preceded by transient neurological aura symptoms. This review, first, briefly summarizes current understanding of the pathophysiological mechanisms that are believed to underlie migraine headache, migraine aura and the onset of a migraine attack, and briefly describes the localization and function of neuronal Ca(V)2.1 channels in the brain regions that have been implicated in migraine pathogenesis. Then, the review describes and discusses i) the functional consequences of FHM1 mutations on the biophysical properties of recombinant human Ca(V)2.1 channels and native Ca(V)2.1 channels in neurons of knockin mouse models carrying the mild R192Q or severe S218L mutations in the orthologous gene, and ii) the functional consequences of these mutations on neurophysiological processes in the cerebral cortex and trigeminovascular system thought to be involved in the pathophysiology of migraine, and the insights into migraine mechanisms obtained from the functional analysis of these processes in FHM1 knockin mice. This article is part of a Special Issue entitled: Calcium channels., (Copyright © 2012 Elsevier B.V. All rights reserved.)
Published: 2013
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45. Pathophysiology of migraine.

Author: Pietrobon D and Moskowitz MA
Subjects: Animals, Brain blood supply, Calcitonin Gene-Related Peptide physiology, Disease Models, Animal, Humans, Mice, Synaptic Transmission physiology, Vasodilation physiology, Brain physiopathology, Migraine Disorders physiopathology, Nociceptors physiology
Abstract: Migraine is a collection of perplexing neurological conditions in which the brain and its associated tissues have been implicated as major players during an attack. Once considered exclusively a disorder of blood vessels, compelling evidence has led to the realization that migraine represents a highly choreographed interaction between major inputs from both the peripheral and central nervous systems, with the trigeminovascular system and the cerebral cortex among the main players. Advances in in vivo and in vitro technologies have informed us about the significance to migraine of events such as cortical spreading depression and activation of the trigeminovascular system and its constituent neuropeptides, as well as about the importance of neuronal and glial ion channels and transporters that contribute to the putative cortical excitatory/inhibitory imbalance that renders migraineurs susceptible to an attack. This review focuses on emerging concepts that drive the science of migraine in both a mechanistic direction and a therapeutic direction.
Published: 2013
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46. Migraine: a disorder of brain excitatory-inhibitory balance?

Author: Vecchia D and Pietrobon D
Subjects: Animals, Humans, Brain physiopathology, Migraine Disorders physiopathology, Pain physiopathology, Trigeminal Nerve physiopathology
Abstract: Migraine is a common disabling brain disorder whose key manifestations are recurrent attacks of unilateral headache and interictal hypersensitivity to sensory stimuli. Migraine arises from a primary brain dysfunction that leads to episodic activation and sensitization of the trigeminovascular pain pathway and as a consequence to headache. Major open issues concern the molecular and cellular mechanisms of the primary brain dysfunction(s) and of migraine pain. We review here our current understanding of these mechanisms, focusing on recent advances regarding migraine genetics, headache mechanisms, and the primary brain dysfunction(s) underlying migraine onset and susceptibility to cortical spreading depression, the neurophysiological correlate of migraine aura. We also discuss insights obtained from the functional analysis of familial hemiplegic migraine mouse models., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
Published: 2012
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47. Trigeminal ganglion neuron subtype-specific alterations of Ca(V)2.1 calcium current and excitability in a Cacna1a mouse model of migraine.

Author: Fioretti B, Catacuzzeno L, Sforna L, Gerke-Duncan MB, van den Maagdenberg AM, Franciolini F, Connor M, and Pietrobon D
Subjects: Animals, Calcitonin Gene-Related Peptide physiology, Capsaicin, Cerebellar Ataxia genetics, Disease Models, Animal, Female, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Migraine Disorders genetics, Mutation, Neurons physiology, Calcium Channels, N-Type physiology, Calcium Channels, P-Type physiology, Calcium Channels, Q-Type physiology, Cerebellar Ataxia physiopathology, Migraine Disorders physiopathology, Trigeminal Ganglion physiology
Abstract: Familial hemiplegic migraine type-1 (FHM1), a monogenic subtype of migraine with aura, is caused by gain-of-function mutations in Ca(V)2.1 (P/Q-type) calcium channels. The consequences of FHM1 mutations on the trigeminovascular pathway that generates migraine headache remain largely unexplored. Here we studied the calcium currents and excitability properties of two subpopulations of small-diameter trigeminal ganglion (TG) neurons from adult wild-type (WT) and R192Q FHM1 knockin (KI) mice: capsaicin-sensitive neurons without T-type calcium currents (CS) and capsaicin-insensitive neurons characterized by the expression of T-type calcium currents (CI-T). Small TG neurons retrogradely labelled from the dura are mostly CS neurons, while CI-T neurons were not present in the labelled population. CS and CI-T neurons express Ca(V)2.1 channels with different activation properties, and the Ca(V)2.1 channels are differently affected by the FHM1 mutation in the two TG neuron subtypes. In CI-T neurons from FHM1 KI mice there was a larger P/Q-type current density following mild depolarizations, a larger action potential (AP)-evoked calcium current and a longer AP duration when compared to CI-T neurons from WT mice. In striking contrast, the P/Q-type current density, voltage dependence and kinetics were not altered by the FHM1 mutation in CS neurons. The excitability properties of mutant CS neurons were also unaltered. Congruently, the FHM1 mutation did not alter depolarization-evoked CGRP release from the dura mater, while CGRP release from the trigeminal ganglion was larger in KI compared to WT mice. Our findings suggest that the facilitation of peripheral mechanisms of CGRP action, such as dural vasodilatation and nociceptor sensitization at the meninges, does not contribute to the generation of headache in FHM1.
Published: 2011
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48. Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2.

Author: Leo L, Gherardini L, Barone V, De Fusco M, Pietrobon D, Pizzorusso T, and Casari G
Subjects: Animals, Astrocytes metabolism, Disease Models, Animal, Endoplasmic Reticulum metabolism, Female, Gene Knock-In Techniques, HeLa Cells, Humans, Male, Mice, Mice, Transgenic, Migraine with Aura genetics, Mutagenesis, Insertional, Phenotype, Protein Transport, Reverse Transcriptase Polymerase Chain Reaction, Sodium-Potassium-Exchanging ATPase genetics, Synaptic Transmission, Transfection, Cortical Spreading Depression genetics, Glutamic Acid metabolism, Migraine with Aura pathology, Sodium-Potassium-Exchanging ATPase metabolism
Abstract: Familial hemiplegic migraine type 2 (FHM2) is an autosomal dominant form of migraine with aura that is caused by mutations of the α2-subunit of the Na,K-ATPase, an isoform almost exclusively expressed in astrocytes in the adult brain. We generated the first FHM2 knock-in mouse model carrying the human W887R mutation in the Atp1a2 orthologous gene. Homozygous Atp1a2(R887/R887) mutants died just after birth, while heterozygous Atp1a2(+/R887) mice showed no apparent clinical phenotype. The mutant α2 Na,K-ATPase protein was barely detectable in the brain of homozygous mutants and strongly reduced in the brain of heterozygous mutants, likely as a consequence of endoplasmic reticulum retention and subsequent proteasomal degradation, as we demonstrate in transfected cells. In vivo analysis of cortical spreading depression (CSD), the phenomenon underlying migraine aura, revealed a decreased induction threshold and an increased velocity of propagation in the heterozygous FHM2 mouse. Since several lines of evidence involve a specific role of the glial α2 Na,K pump in active reuptake of glutamate from the synaptic cleft, we hypothesize that CSD facilitation in the FHM2 mouse model is sustained by inefficient glutamate clearance by astrocytes and consequent increased cortical excitatory neurotransmission. The demonstration that FHM2 and FHM1 mutations share the ability to facilitate induction and propagation of CSD in mouse models further support the role of CSD as a key migraine trigger., Competing Interests: The authors have declared that no competing interests exist.
Published: 2011
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49. Role of different voltage-gated Ca2+ channels in cortical spreading depression: specific requirement of P/Q-type Ca2+ channels.

Author: Tottene A, Urbani A, and Pietrobon D
Subjects: Animals, Brain metabolism, Calcium metabolism, Cells, Cultured, Glutamic Acid metabolism, Mice, Mice, Transgenic, Migraine Disorders metabolism, Neurons metabolism, Pyramidal Cells cytology, Receptors, N-Methyl-D-Aspartate metabolism, Synaptic Transmission, Calcium Channels chemistry, Calcium Channels, P-Type metabolism, Calcium Channels, Q-Type metabolism, Cortical Spreading Depression
Abstract: Gain-of-function mutations in CaV 2.1 (P/Q-type) Ca2+ channels cause familial hemiplegic migraine type 1 (FHM1), a subtype of migraine with aura. Knockin (KI) mice carrying FHM1 mutations show increased neuronal P/Q-type current and facilitation of induction and propagation of cortical spreading depression (CSD), the phenomenon that underlies migraine aura and may activate migraine headache mechanisms. We recently studied cortical neurotransmission in neuronal microcultures and brain slices of FHM1 KI mice, and showed (1) gain-of-function of excitatory neurotransmission, due to increased action potential-evoked Ca2+ influx and increased probability of glutamate release at pyramidal cell synapses, but unaltered inhibitory neurotransmission at fast-spiking interneuron synapses, and (2) a causative link between enhanced glutamate release and facilitation of CSD induced by brief pulses of high K+ in cortical slices. Here, we show that after blockade of either the P/Q-type Ca2+ channels or the NMDA receptors, CSD cannot be induced in wild-type mouse cortical slices. In contrast, blockade of N- or R-type Ca2+ channels has only a small inhibitory effect on CSD threshold and velocity of propagation. Our findings support a model in which Ca2+ influx through presynaptic P/Q-type Ca2+ channels with consequent release of glutamate from recurrent cortical pyramidal cell synapses and activation of NMDA receptors are required for initiation and propagation of the CSD involved in migraine.
Published: 2011
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50. CaV2.1 channelopathies.

Author: Pietrobon D
Subjects: Animals, Ataxia genetics, Calcium Channels genetics, Calcium Channels, N-Type physiology, Cortical Spreading Depression genetics, Gene Knock-In Techniques, Humans, Mice, Migraine with Aura genetics, Models, Animal, Protein Structure, Secondary, Recombinant Proteins metabolism, Spinocerebellar Ataxias genetics, Synaptic Transmission genetics, Calcium Channels, N-Type genetics, Channelopathies genetics
Abstract: Mutations in the CACNA1A gene that encodes the pore-forming alpha1 subunit of human voltage-gated CaV2.1 (P/Q-type) Ca2+ channels cause several autosomal-dominant neurologic disorders, including familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2, and spinocerebellar ataxia type 6 (SCA6). For each channelopathy, the review describes the disease phenotype as well as the functional consequences of the disease-causing mutations on recombinant human CaV2.1 channels and, in the case of FHM1 and SCA6, on neuronal CaV2.1 channels expressed at the endogenous physiological level in knockin mouse models. The effects of FHM1 mutations on cortical spreading depression, the phenomenon underlying migraine aura, and on cortical excitatory and inhibitory synaptic transmission in FHM1 knockin mice are also described, and their implications for the disease mechanism discussed. Moreover, the review describes different ataxic spontaneous cacna1a mouse mutants and the important insights into the cerebellar mechanisms underlying motor dysfunction caused by mutant CaV2.1 channels that were obtained from their functional characterization.
Published: 2010
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