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123 results on '"Düsman, Elisângela"'

2. Antioxidant and cytotoxic properties of optimized aril extracts from Passiflora edulis f. flavicarpa: A sustainable source of functional bioactives

Author

Silva, Israel Keller, Berton, Guilherme Henrique, Biffi, Mariana Tonello, Bressiani, Patrícia Aline, Balbinot-Alfaro, Evellin, Concato, Virginia Marcia, Pavanelli, Wander Rogério, Knob, Fernanda Carolina, Oldoni, Tatiane Luiza Cadorin, de Oliveira Schmitz, Ana Paula, Canteri, Maria Helene Giovanetti, and Düsman, Elisângela

Published
2024
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4. Valorization of Wastes from the Juice Passion Fruit Production Industry: Extraction of Bioactive Compounds from Seeds, Antioxidant, Photoprotective and Antiproliferative Activities

Author

dos Santos, Grazielle Jesus, Defendi, Rafael Oliveira, Düsman, Elisângela, Biffi, Mariana Tonello, Berton, Guilherme Henrique, Tonin, Angélica Priscila Parussolo, Meurer, Eduardo César, Suzuki, Rúbia Michele, Sípoli, Caroline Casagrande, and Tonin, Lilian Tatiani Dusman

Published
2023
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5. Soil toxicity in a protected area in Brazil: Cytotoxic, genotoxic, and toxic effects

Author

Schutz, Daiana Lauxen, de Marco, Inara Giacobbo, Teles, Anna Gabriela Drummond Xavier, de Oliveira Schmitz, Ana Paula, Gomes, Eduardo Michel Vieira, Manosso, Fernando Cesar, Tonial, Ivane Benedetti, Pokrywiecki, Juan Carlos, Lingnau, Rodrigo, Pokrywieki, Ticiane Sauer, Módenes, Aparecido Nivaldo, Quiñones, Fernando Rodolfo Espinoza, and Düsman, Elisângela

Published
2023
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7. Waters Biomonitoring of the Marrecas River (Paraná, Brazil) at Different Trophic Levels

Author

Couto, Mário Sérgio Braga do, primary, Salla, Larissa, additional, Biffi, Mariana Tonello, additional, Alves, Geiciane Locatelli, additional, Follador, Franciele Aní Caovilla, additional, Soares, Izabel Aparecida, additional, Hellmann, Liliane, additional, Schmitz, Ana Paula de Oliveira, additional, Pokrywiecki, Juan Carlos, additional, Pokrywiecki, Ticiane Sauer, additional, Manosso, Fernando Cesar, additional, Düsman, Elisângela, additional, Hendges, Elvis Rabuske, additional, Andres, Juliano, additional, Gomes, Eduardo Michel Vieira, additional, and Aruda, Gisele, additional

Published
2024
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10. Cytotoxicity and mutagenicity of the waters of the Marrecas River (Paraná, Brazil) to bullfrogs (Lithobates catesbeianus)

Author

dos Santos, Flavia Isabelli, Mizobata, Andressa Akemi, Suyama, Gabrielle Arisa, Cenci, Giovana Baptista, Follador, Franciele Ani Caovilla, Arruda, Gisele, Hellmann, Liliane, Gomes, Eduardo Michel Vieira, de Oliveira Schmitz, Ana Paula, Pokrywiecki, Juan Carlos, Lingnau, Rodrigo, Manosso, Fernando Cesar, Pokrywiecki, Ticiane Sauer, and Düsman, Elisângela

Published
2021
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13. Biomonitoring of surface water quality in the Chopim River within the Conservation Unit Campos de Palmas Wildlife Refuge, southern Brazil

Author

Schutz, Daiana Lauxen, de Marco, Inara Giacobbo, Alves, Geiciane Locatelli, Vincoski, José Vitor Abilhõa, Ishikawa, Sabrina, de Oliveira Schmitz, Ana Paula, Gomes, Eduardo Michel Vieira, Manosso, Fernando Cesar, Tonial, Ivane Benedetti, Pokrywiecki, Juan Carlos, Lingnau, Rodrigo, Pokrywieki, Ticiane Sauer, and Düsman, Elisângela

Published
2021
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19. Evaluation of genotoxicity and cytotoxicity of inhabitants of Vila Rural Água Viva, Brazil, exposed to agrochemicals using the micronucleus buccal cytome assay

Author

Bressiani, Patricia Aline, primary, Alves, Geiciane Locatelli, additional, de Marco, Inara Giacobbo, additional, Biffi, Mariana Tonello, additional, Ishikawa, Sabrina, additional, Manosso, Fernando César, additional, Gomes, Eduardo Michel Vieira, additional, Pokrywiecki, Ticiane Sauer, additional, Schmitz, Ana Paula de Oliveira, additional, and Düsman, Elisângela, additional

Published
2022
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20. Valorization of Wastes from the Juice Passion Fruit Production Industry: Extraction of Bioactive Compounds from Seeds, Antioxidant, Photoprotective and Antiproliferative Activities

Author

dos Santos, Grazielle Jesus, primary, Defendi, Rafael Oliveira, additional, Düsman, Elisângela, additional, Biffi, Mariana Tonello, additional, Berton, Guilherme Henrique, additional, Tonin, Angélica Priscila Parussolo, additional, Meurer, Eduardo César, additional, Suzuki, Rúbia Michele, additional, Sípoli, Caroline Casagrande, additional, and Tonin, Lilian Tatiani Dusman, additional

Published
2022
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25. Caracteristicas e aplicações dos Glicosaminoglicanos: uso de subprodutos da indústria de alimentos/ Characteristics and applications of glycosaminoglycans: use of by-products of the food industry

Author

Moura, Heloisa Cristina de, Novello, Cláudio Roberto, Alfaro, Alexandre da Trindade, Barddal, Helyn Priscila de Oliveira, Alfaro, Evellin Balbinot, and Düsman, Elisângela

Subjects
Polissacarídeos. GAG’s. Propriedades terapêuticas
Abstract

Os glicosaminoglicanos (GAG´s) são polissacarídeos aniônicos, lineares, compostos basicamente por hexosamina, ácido urônico e galactose. São eles o sulfato de condroitina (CS), sulfato de dermatana (DS), ácido hialurônico (HA), sulfato de queratana (KS), heparina (HE) e sulfato de heparana (HS). A diferença de densidade de cargas negativas e o grau de sulfatação determinam suas propriedades estruturais e biológicas. As propriedades terapêuticas dos GAG´s estão correlacionadas com sua capacidade de se ligar as proteínas. Os GAG´s sulfatados têm sido amplamente utilizados como anticoagulantes, com destaque para a heparina (HE). Diversos estudos também apontam para atividades regenerativa, antiviral, antiproliferativa e anti-inflamatória. A crescente demanda por GAG´s está impulsionando uma série de pesquisas para a descoberta de novas fontes de isolamento. Os subprodutos da indústria de alimentos são uma potencial fonte para obtenção de glicosaminoglicanos.

Published
2020
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26. Obtaining glycosaminoglycans from tilapia (oreochromis niloticus) scales and evaluation of its anticoagulant and cytotoxic activities

Author

de Moura, Heloisa C., primary, Novello, Claudio R., additional, Balbinot-Alfaro, Evellin, additional, Düsman, Elisângela, additional, Barddal, Helyn P.O., additional, Almeida, Igor V., additional, Vicentini, Veronica E.P., additional, Prentice-Hernández, Carlos, additional, and Alfaro, Alexandre T., additional

Published
2021
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31. Treatment of effluent containing thiamethoxam and efficiency evaluation of toxicity reduction.

Author

Fieira, Clarice, Batistella, Eduardo Pavan, Vincoski, Jose Vitor Abilhoa, Rosa, Marcos Paulo Scaglia, Pokrywiecki, Juan Carlos, Gomes, Eduardo Michel Vieira, de Oliveira, Ana Paula, Sauer Pokrywiecki, Ticiane, and Düsman, Elisângela

Subjects
WATER purification, THIAMETHOXAM, RICE hulls, ACTIVATED carbon, ONIONS, CORN straw, CORN seeds
Abstract

The treatment of seeds using pesticides is a widely employed technique that generates effluents with high contamination potential. In the present study, our objective was to characterize and evaluate the toxicity of washing wastewater from corn seed treaters that contained the pesticide thiamethoxam. Effluents were treated by adsorption using several adsorbent materials, namely activated vegetable carbon, corn straw, and soybean hulls, different pH, and distinct mass concentrations for each material. The activated carbon promoted a greater reduction in the chemical oxygen demand (COD). In the coagulation-flocculation treatment, with ferric chloride (FeCl3) and poly-aluminum chloride (PAC), and using factorial planning with the concentration of FeCl3 and the sedimentation time as independent variables, the best COD removal occurred with 850 mg L−1 FeCl3 and 120 min sedimentation. The treatments C (coagulation), CACA (coagulation followed by adsorption with activated vegetable carbon), and CACS (coagulation followed by adsorption with corn straw) presented the most efficacious physicochemical parameter changes. The CACA treatment showed the best result for removing thiamethoxam. Nevertheless, raw and treated effluents showed high toxicity to the bioindicators Artemia salina L. (immobility/mortality test), Eisenia fetida (avoidance test), and Allium cepa L. (cytotoxicity test). The effluents also produced a mutagenic effect for A. cepa, due to the presence of chromosomal changes. The results demonstrated the risk that this effluent can cause to the environment. These data highlight the need to investigate new technologies to reduce the physicochemical parameters, the agrochemical levels, and, in particular, the final effluent toxicity. [ABSTRACT FROM AUTHOR]

Published
2021
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34. The mutagenic effect of psychostimulant modafinil in Wistar rats in vivo.

Author

Penna, Lívia Maria de Castro, Düsman, Elisângela, and Vicentini, Veronica Elisa Pimenta

Subjects
*SLEEP apnea syndromes, *RATTUS norvegicus, *HUMAN beings, *RATS, *SLEEP disorders, *BODY weight
Abstract

The demands imposed by today's world require a fast and efficient society, then, significant section of the population looks for support from psychotropic medicine. Modafinil is a psychostimulant that promotes wakefulness, it being recommended for treatment of narcolepsy, obstructive sleep apnea, and shift-work sleep disorder, besides being a cognitive function potentiator. However, chemical components of drugs can alter genetic material. Thus, the present study evaluated the cytotoxic and clastogenic/mutagenic potential of 0.25, 0.50, and 0.75 mg of Modafinil/mL of corn oil/100g body weight in acute treatments and subacute treatments, 15 days, to Rattus norvegicus, treated via gavage in a single daily dose. The drug was not cytotoxic at any of the evaluated doses in either of the treatments. However, the medicine showed clastogenic/mutagenic activity in the acute treatment group at the standard dose and at double dose. Data from the present study indicates that there should be greater caution as to the use of this psychostimulant by human beings. [ABSTRACT FROM AUTHOR]

Published
2020
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36. Cytotoxic potential of waters of the streams Mandacaru, Maringá, Miosótis and Nazareth in the urban area of Maringá, Paraná State, Brazil - doi: 10.4025/actascibiolsci.v34i3.8275

Author

Düsman, Elisângela, Gonçalves, Larissa Aparecida, Reusing, Ana Flávia, Martin, Paula Garcia, Mariucci, Rosinete Gonçalves, and Vicentini, Veronica Elisa Pimenta

Subjects
Allium cepa L, lcsh:Biology (General), QH301-705.5, stream water, lcsh:QR1-502, cytotoxicity, Biology (General), Genética, Microbiology, lcsh:QH301-705.5, QR1-502, lcsh:Microbiology
Abstract

Streams Mandacaru, Maringá, Miosótis and Nazareth in the urban area of Maringá, Estado do Paraná, Brazil are affected by the local population’s polluting practices. Meristemic cells of Allium cepa L. roots were used as test system to evaluate the cytotoxic effects of the streams’ water. Onion roots were prepared by Feulgen reaction and stained with Schiff's reagent. Statistical analysis of the mitotic index was undertaken with the chi-square test. Results did not show significant cytotoxic effect of water samples. Results may dependent on climate variations, concentration of harmful substances, and on the time and samples sites evaluated. A deeper awareness of the population should be underscored for the proper use, preservation and maintenance of soil and water, with particular emphasis to this region.

Published
2012

38. Changes in physicochemical and toxicological parameters of waters of Trincheira's River caused by road construction.

Author

Salcedo Restrepo, Juan Camilo Pires, Iara Antonelo, Danieli, Sauer Pokrywiecki, Ticiane, Benedetti Tonial, Ivane, César Manosso, Fernando, de Almeida, Igor Vivian, Pimenta Vicentini, Veronica Elisa, and Düsman, Elisângela

Subjects
ROAD construction, WATER quality, BODIES of water, BIOCHEMICAL oxygen demand, SHELLFISH, ONIONS, RIVERS
Abstract

Copyright of Revista Ambiente e Água is the property of Revista Ambiente e Agua and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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39. Cytotoxicity, mutagenicity, and antimutagenicity of the gentisic acid on HTC cells.

Author

Cavalcante, Flavia Maria Lima, Almeida, Igor Vivian, Düsman, Elisângela, Mantovani, Mário Sérgio, and Vicentini, Veronica Elisa Pimenta

Subjects
PHYSIOLOGICAL effects of phenols, CELL-mediated cytotoxicity, ANTIOXIDANTS, MUTAGENESIS, CELL proliferation, DNA damage, PREVENTION
Abstract

Gentisic acid (GA) exhibits antioxidant, anti-inflammatory, and antibiotic activities. This substance can be found in citrus fruits, grapes, olive oil, and peas. Considering that there are few studies in the literature on the toxicity of GA, the present work aimed to investigate its cytotoxic, mutagenic, and antimutagenic activities on HTC cells. GA was diluted in culture medium at the final concentration of 0.08, 0.16, 0.8, 1.6, and 8 μg/mL. The cytotoxicity was determined by the MTT assay and Trypan Blue exclusion method, with methyl methanesulfonate and doxorubicin as positive controls, respectively. The cytokinesis-block micronucleus assay determined the mutagenic/antimutagenic activity with benzo[a]pyrene as positive control. Negative control received culture medium only. GA (0.08–8 μg/mL) was not cytotoxic to HTC cells by the MTT assay nor the Trypan Blue exclusion method as no statistical difference was observed when compared to the control. Concentration of 0.08 and 0.8 μg/mL showed no mutagenic or clastogenic effects, as no significant micronuclei inductions were observed, different from 8 μg/mL, that was mutagenic. Furthermore, none of the concentrations presented an antiproliferative activity. The antimutagenic activity of GA (0.08 μg/mL) was observed at the simultaneous treatment, as it reduced the frequency of micronuclei by 76% (24 h) and 79% (48 h). Although pre- and post-treatments were not statistically different from the mutagen, they reduced the induced-damage by 11% and 21%, respectively. The present study indicated the absence of cytotoxicity and antiproliferative activities of GA, in addition to their antimutagenic/protective effects that may contribute to human health. [ABSTRACT FROM PUBLISHER]

Published
2018
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40. Vegetal test-system investigation on cytotoxicity of water from urban streams located in the northeastern region of Maringá, Paraná State, Brazil - doi: 10.4025/actascibiolsci.v33i1.4924

Author

Düsman, Elisângela, Faria, Juliana Sala de, Toledo, Fabiana, Mazeti, Camila Montoro, Gonçalves, Marcus Eduardo Kamide, and Vicentini, Veronica Elisa Pimenta

Subjects
Allium cepa, environmental mutagenesis, water contamination, Mutagênese
Abstract

The increase in consumption of water, the destruction of riparian forests and the pollution caused by humans, have severely degraded several water resources. Numerous stream crisscross the city of Maringá, Paraná state, Brazil and most of their sources are scattered through the urban region. Current analysis assesses the cytotoxic potential of water from the Corregozinho, Isalto, Morangueira and Ozório streams, located within the high-populated northeastern region of Maringá, inside the urban perimeter. Root meristematic cells of Allium cepa were used as test-system. The roots of onion were prepared by Feulgen’s reaction and stained with Schiff's reagent. Results showed that there were no statistically significant changes evaluated by the chi-square test on the rates of cell division in cells of Allium cepa roots treated with the water of the streams when compared to data from controls. However, further analyses should be undertaken at different times for a periodic assessment of conditions in the streams, coupled with an awareness of the population on the environment. The increase in consumption of water, the destruction of riparian forests and the pollution caused by humans, have severely degraded several water resources. Numerous stream crisscross the city of Maringá, Paraná state, Brazil and most of their sources are scattered through the urban region. Current analysis assesses the cytotoxic potential of water from the Corregozinho, Isalto, Morangueira and Ozório streams, located within the high-populated northeastern region of Maringá, inside the urban perimeter. Root meristematic cells of Allium cepa were used as test-system. The roots of onion were prepared by Feulgen’s reaction and stained with Schiff's reagent. Results showed that there were no statistically significant changes evaluated by the chi-square test on the rates of cell division in cells of Allium cepa roots treated with the water of the streams when compared to data from controls. However, further analyses should be undertaken at different times for a periodic assessment of conditions in the streams, coupled with an awareness of the population on the environment.

Published
2011

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