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1. Burden of post–acute COVID-19 sequelae in healthcare workers and its course over a 30-month period–results from a prospective multicentre cohort

Author

Dörr, Tamara, Strahm, Carol, Güsewell, Sabine, Ballouz, Tala, Kocan, Emina, Cusini, Alexia, Goppel, Stephan, Grässli, Fabian, Möller, J. Carsten, Puhan, Milo A., Risch, Lorenz, Ruetti, Markus, Schlegel, Matthias, Stocker, Reto, von Kietzell, Matthias, Vuichard-Gysin, Danielle, Kuster, Stefan P., Kahlert, Christian R., and Kohler, Philipp

Published
2024
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2. Association of institutional masking policies with healthcare-associated SARS-CoV-2 infections in Swiss acute care hospitals during the BA.4/5 wave (CH-SUR study): a retrospective observational study

Author

Dörr, Tamara, Güsewell, Sabine, Flury, Domenica, Süveges, Maria, Gaza Valera, Camille Beatrice, Botero-Mesa, Sara, Zanella, Marie-Céline, Iten, Anne, Balmelli, Carlo, Troillet, Nicolas, Tschudin-Sutter, Sarah, W Schreiber, Peter, Jent, Philipp, Damonti, Lauro, Sommerstein, Rami, Portmann, Lea, Vuichard-Gysin, Danielle, Cusini, Alexia, Nussbaumer-Ochsner, Yvonne, Heininger, Ulrich, Berger, Christoph, Zimmermann, Petra, Gardiol, Céline, Keiser, Olivia, Schlegel, Matthias, Kohler, Philipp, and P Kuster, Stefan

Published
2024
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5. SARS‐CoV‐2 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study.

Author

Dörr, Tamara, Güsewell, Sabine, Cusini, Alexia, Brucher, Angela, Goppel, Stephan, Grässli, Fabian, Betschon, Elsbeth, Möller, J. Carsten, Ortner, Manuela, Ruetti, Markus, Stocker, Reto, Vuichard‐Gysin, Danielle, Besold, Ulrike, Risch, Lorenz, von Kietzell, Matthias, Schlegel, Matthias, Kuster, Stefan P., Kahlert, Christian R., and Kohler, Philipp

Subjects
*MEDICAL personnel, *SARS-CoV-2, *VACCINE hesitancy, *INFERTILITY, *VACCINATION, *COHORT analysis
Abstract

Background: There is debate about the causes of the recent birth rate decline in high‐income countries worldwide. During the pandemic, concern about the effects on reproductive health has caused vaccine hesitancy. We investigated the association of SARS‐CoV‐2 vaccination and infection with involuntary childlessness. Methods: Females in fertility age within a prospective multicenter cohort of healthcare workers (HCW) were followed since August 2020. Data on baseline health, SARS‐CoV‐2‐infection, and vaccination were obtained and regularly updated, in which serum samples were collected repetitively and screened for anti‐nucleocapsid and anti‐spike antibodies. In October 2023, participants indicated the presence of involuntary childlessness with onset during the pandemic, whereas those indicating an onset before the pandemic were excluded. The association of involuntary childlessness and SARS‐CoV‐2‐vaccination and infection was investigated using univariable and multivariable analysis. Sensitivity analysis was performed to compare those reporting involuntary childlessness with those birthing a child since 2020. Results: Of 798 participants, 26 (3.2%) reported involuntary childlessness starting since the pandemic. Of the involuntary childless women, 73.1% (19/26) were vaccinated compared to 86.0% (664/772) without involuntary childlessness (p = 0.73). SARS‐CoV‐2 infection was reported by 76.9% (20/26) compared to 72.4% (559/772) of controls (p = 0.64). Neither SARS‐CoV‐2 vaccination (aOR 0.91 per dose, 95%CI 0.67–1.26) nor infection (aOR per infection 1.05, 95%CI 0.62–1.71) was associated with involuntary childlessness. Sensitivity analysis confirmed these results. Conclusions: Among female HCW of fertility age, 3.2% indicated involuntary childlessness, which is comparable to pre‐pandemic data. No association between involuntary childlessness and SARS‐CoV‐2 vaccination or infection was found. [ABSTRACT FROM AUTHOR]

Published
2024
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6. List of Contributors

Author

Agache, Ioana, primary, Akdis, Cezmi A., additional, Alvarez-Perea, Alberto, additional, Amaral, Rita, additional, Antolín-Amérigo, Darío, additional, Bachert, Claus, additional, Baiardini, Ilaria, additional, Berkouk, Karim, additional, Bewick, Mike, additional, Bousquet, Jean, additional, Canonica, Giorgio Walter, additional, Cojanu, Catalina, additional, Crisafulli, Aldo, additional, Desrosiers, Martin, additional, Dörr, Tamara, additional, Endam, Leandra Mfuna, additional, Ferrando, Matteo, additional, Fokkens, Wytske, additional, Fonseca, João A, additional, Gajdanowicz, Paweł, additional, Haahtela, Tari, additional, Hanrahan, Finnian, additional, Heffler, Enrico, additional, Hellings, Peter W., additional, Hofmaier, Stephanie, additional, Hofman, Ingrid van, additional, Hogan, Stéphane, additional, Hopkins, Claire, additional, Huang, Xinyuan, additional, Jacinto, Tiago, additional, Jácome, Cristina, additional, Jones, Christina, additional, Jutel, Marek, additional, Kogan, Grigorij, additional, Laang, Hannu, additional, Lund, Valerie J., additional, Lunjani, Nonhlanhla, additional, Mäkelä, Mika J., additional, Mariën, Gert, additional, Matricardi, Paolo Maria, additional, Matthiessen, Line, additional, Nowak, Elisabeth, additional, O’Mahony, Liam, additional, Paoletti, Giovanni, additional, Pereira, Ana Margarida, additional, Popescu, Florin-Dan, additional, Pugin, Benoit, additional, Rogozea, Liliana, additional, Ryan, Dermot, additional, Saarinen, Kimmo, additional, Schaub, Bianca, additional, Schmidt-Weber, Carsten B., additional, Sedillot, Eve, additional, Seys, Sven F., additional, Smith, Helen E., additional, Sokolowska, Milena, additional, Steelant, Brecht, additional, Sugita, Kazunari, additional, Tomassen, Peter, additional, Tommila, Erja, additional, Trzaska, Dominika, additional, Valovirta, Erkka, additional, Vasankari, Tuula, additional, Vidal-Ragout, María, additional, Wong, Gary W.K., additional, Yorgancıoğlu, Arzu, additional, and Zuberbier, Torsten, additional

Published
2019
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9. Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food—A first step in an initiative to better inform patients and avoid fatal allergic reactions:A GA²LEN position paper

Author

Zuberbier, Torsten, Dörr, Tamara, Aberer, Werner, Alvaro, Montserrat, Angier, Elizabeth, Arasi, Stefania, Arshad, Hasan, Ballmer-Weber, Barbara, Bartra, Joan, Beck, Lisa, Bégin, Philippe, Bindslev-Jensen, Carsten, Bislimovska, Jovanka, Bousquet, Jean, Brockow, Knut, Bush, Andrew, Cianferoni, Antonella, Cork, Michael J., Custovic, Adnan, Darsow, Ulf, de Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano, Deschildre, Antoine, Dunn Galvin, Audrey, Ebisawa, Motohiro, Fernández-Rivas, Montserrat, Ferrer, Marta, Fiocchi, Alessandro, Gerth van Wijk, Roy, Gotua, Maia, Grimshaw, Kate, Grünhagen, Josefine, Heffler, Enrico, Hide, Michihiro, Hoffmann-Sommergruber, Karin, Incorvaia, Cristoforo, Janson, Christer, Malte John, Swen, Jones, Carla, Jutel, Marek, Katoh, Norito, Kendziora, Benjamin, Kinaciyan, Tamar, Knol, Edward, Kurbacheva, Oksana, Lau, Susanne, Loh, Richard, Lombardi, Carlo, Mäkelä, Mika, Marchisotto, Mary Jane, Makris, Michael, Maurer, Marcus, Meyer, Rosan, Mijakoski, Dragan, Minov, Jordan, Mullol, Joaquim, Nilsson, Caroline, Nowak–Wegrzyn, Anna, Nwaru, Bright I., Odemyr, Mikela, Pajno, Giovanni Battista, Paudel, Sushil, Papadopoulos, Nikolaos G., Renz, Harald, Ricci, Giampaolo, Ring, Johannes, Rogala, Barbara, Sampson, Hugh, Senna, Gianenrico, Sitkauskiene, Brigita, Smith, Peter Kenneth, Stevanovic, Katarina, Stoleski, Sasho, Szajewska, Hania, Tanaka, Akio, Todo-Bom, Ana, Topal, Fatih Alexander, Valovirta, Erkka, Van Ree, Ronald, Venter, Carina, Wöhrl, Stefan, Wong, Gary W.K., Zhao, Zuotao, Worm, Margitta, Zuberbier, Torsten, Dörr, Tamara, Aberer, Werner, Alvaro, Montserrat, Angier, Elizabeth, Arasi, Stefania, Arshad, Hasan, Ballmer-Weber, Barbara, Bartra, Joan, Beck, Lisa, Bégin, Philippe, Bindslev-Jensen, Carsten, Bislimovska, Jovanka, Bousquet, Jean, Brockow, Knut, Bush, Andrew, Cianferoni, Antonella, Cork, Michael J., Custovic, Adnan, Darsow, Ulf, de Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano, Deschildre, Antoine, Dunn Galvin, Audrey, Ebisawa, Motohiro, Fernández-Rivas, Montserrat, Ferrer, Marta, Fiocchi, Alessandro, Gerth van Wijk, Roy, Gotua, Maia, Grimshaw, Kate, Grünhagen, Josefine, Heffler, Enrico, Hide, Michihiro, Hoffmann-Sommergruber, Karin, Incorvaia, Cristoforo, Janson, Christer, Malte John, Swen, Jones, Carla, Jutel, Marek, Katoh, Norito, Kendziora, Benjamin, Kinaciyan, Tamar, Knol, Edward, Kurbacheva, Oksana, Lau, Susanne, Loh, Richard, Lombardi, Carlo, Mäkelä, Mika, Marchisotto, Mary Jane, Makris, Michael, Maurer, Marcus, Meyer, Rosan, Mijakoski, Dragan, Minov, Jordan, Mullol, Joaquim, Nilsson, Caroline, Nowak–Wegrzyn, Anna, Nwaru, Bright I., Odemyr, Mikela, Pajno, Giovanni Battista, Paudel, Sushil, Papadopoulos, Nikolaos G., Renz, Harald, Ricci, Giampaolo, Ring, Johannes, Rogala, Barbara, Sampson, Hugh, Senna, Gianenrico, Sitkauskiene, Brigita, Smith, Peter Kenneth, Stevanovic, Katarina, Stoleski, Sasho, Szajewska, Hania, Tanaka, Akio, Todo-Bom, Ana, Topal, Fatih Alexander, Valovirta, Erkka, Van Ree, Ronald, Venter, Carina, Wöhrl, Stefan, Wong, Gary W.K., Zhao, Zuotao, and Worm, Margitta

Abstract

Background: Food anaphylaxis is commonly elicited by unintentional ingestion of foods containing the allergen above the tolerance threshold level of the individual. While labeling the 14 main allergens used as ingredients in food products is mandatory in the EU, there is no legal definition of declaring potential contaminants. Precautionary allergen labeling such as “may contain traces of” is often used. However, this is unsatisfactory for consumers as they get no information if the contamination is below their personal threshold. In discussions with the food industry and technologists, it was suggested to use a voluntary declaration indicating that all declared contaminants are below a threshold of 0.5 mg protein per 100 g of food. This concentration is known to be below the threshold of most patients, and it can be technically guaranteed in most food production. However, it was also important to assess that in case of accidental ingestion of contaminants below this threshold by highly allergic patients, no fatal anaphylactic reaction could occur. Therefore, we performed a systematic review to assess whether a fatal reaction to 5mg of protein or less has been reported, assuming that a maximum portion size of 1kg of a processed food exceeds any meal and thus gives a sufficient safety margin. Methods: MEDLINE and EMBASE were searched until 24 January 2021 for provocation studies and case reports in which one of the 14 major food allergens was reported to elicit fatal or life-threatening anaphylactic reactions and assessed if these occurred below the ingestion of 5mg of protein. A Delphi process was performed to obtain an expert consensus on the results. Results: In the 210 studies included, in our search, no reports of fatal anaphylactic reactions reported below 5 mg protein ingested were identified. However, in provocation studies and case reports, severe reactions below 5 mg were reported for the following allergens: eggs, fish, lupin, milk, nuts, peanuts, soy

Published
2022

10. Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food—A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA²LEN position paper

Author

CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Zuberbier, Torsten, Dörr, Tamara, Aberer, Werner, Alvaro, Montserrat, Angier, Elizabeth, Arasi, Stefania, Arshad, Hasan, Ballmer-Weber, Barbara, Bartra, Joan, Beck, Lisa, Bégin, Philippe, Bindslev-Jensen, Carsten, Bislimovska, Jovanka, Bousquet, Jean, Brockow, Knut, Bush, Andrew, Cianferoni, Antonella, Cork, Michael J, Custovic, Adnan, Darsow, Ulf, de Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano, Deschildre, Antoine, Dunn Galvin, Audrey, Ebisawa, Motohiro, Fernández-Rivas, Montserrat, Ferrer, Marta, Fiocchi, Alessandro, Gerth van Wijk, Roy, Gotua, Maia, Grimshaw, Kate, Grünhagen, Josefine, Heffler, Enrico, Hide, Michihiro, Hoffmann-Sommergruber, Karin, Incorvaia, Cristoforo, Janson, Christer, Malte John, Swen, Jones, Carla, Jutel, Marek, Katoh, Norito, Kendziora, Benjamin, Kinaciyan, Tamar, Knol, Edward, Kurbacheva, Oksana, Lau, Susanne, Loh, Richard, Lombardi, Carlo, Mäkelä, Mika, Marchisotto, Mary Jane, Makris, Michael, Maurer, Marcus, Meyer, Rosan, Mijakoski, Dragan, Minov, Jordan, Mullol, Joaquim, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nwaru, Bright I, Odemyr, Mikela, Pajno, Giovanni Battista, Paudel, Sushil, Papadopoulos, Nikolaos G, Renz, Harald, Ricci, Giampaolo, Ring, Johannes, Rogala, Barbara, Sampson, Hugh, Senna, Gianenrico, Sitkauskiene, Brigita, Smith, Peter Kenneth, Stevanovic, Katarina, Stoleski, Sasho, Szajewska, Hania, Tanaka, Akio, Todo-Bom, Ana, Topal, Fatih Alexander, Valovirta, Erkka, Van Ree, Ronald, Venter, Carina, Wöhrl, Stefan, Wong, Gary W K, Zhao, Zuotao, Worm, Margitta, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Zuberbier, Torsten, Dörr, Tamara, Aberer, Werner, Alvaro, Montserrat, Angier, Elizabeth, Arasi, Stefania, Arshad, Hasan, Ballmer-Weber, Barbara, Bartra, Joan, Beck, Lisa, Bégin, Philippe, Bindslev-Jensen, Carsten, Bislimovska, Jovanka, Bousquet, Jean, Brockow, Knut, Bush, Andrew, Cianferoni, Antonella, Cork, Michael J, Custovic, Adnan, Darsow, Ulf, de Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano, Deschildre, Antoine, Dunn Galvin, Audrey, Ebisawa, Motohiro, Fernández-Rivas, Montserrat, Ferrer, Marta, Fiocchi, Alessandro, Gerth van Wijk, Roy, Gotua, Maia, Grimshaw, Kate, Grünhagen, Josefine, Heffler, Enrico, Hide, Michihiro, Hoffmann-Sommergruber, Karin, Incorvaia, Cristoforo, Janson, Christer, Malte John, Swen, Jones, Carla, Jutel, Marek, Katoh, Norito, Kendziora, Benjamin, Kinaciyan, Tamar, Knol, Edward, Kurbacheva, Oksana, Lau, Susanne, Loh, Richard, Lombardi, Carlo, Mäkelä, Mika, Marchisotto, Mary Jane, Makris, Michael, Maurer, Marcus, Meyer, Rosan, Mijakoski, Dragan, Minov, Jordan, Mullol, Joaquim, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nwaru, Bright I, Odemyr, Mikela, Pajno, Giovanni Battista, Paudel, Sushil, Papadopoulos, Nikolaos G, Renz, Harald, Ricci, Giampaolo, Ring, Johannes, Rogala, Barbara, Sampson, Hugh, Senna, Gianenrico, Sitkauskiene, Brigita, Smith, Peter Kenneth, Stevanovic, Katarina, Stoleski, Sasho, Szajewska, Hania, Tanaka, Akio, Todo-Bom, Ana, Topal, Fatih Alexander, Valovirta, Erkka, Van Ree, Ronald, Venter, Carina, Wöhrl, Stefan, Wong, Gary W K, Zhao, Zuotao, and Worm, Margitta

Published
2022

11. Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food—A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA²LEN position paper

Author

Zuberbier, Torsten; https://orcid.org/0000-0002-1466-8875, Dörr, Tamara, Aberer, Werner, Alvaro, Montserrat; https://orcid.org/0000-0002-5528-8043, Angier, Elizabeth, Arasi, Stefania; https://orcid.org/0000-0002-8135-0568, Arshad, Hasan; https://orcid.org/0000-0001-5988-235X, Ballmer-Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Bartra, Joan; https://orcid.org/0000-0001-7767-4730, Beck, Lisa; https://orcid.org/0000-0002-8452-667X, Bégin, Philippe; https://orcid.org/0000-0002-9089-4604, Bindslev‐Jensen, Carsten; https://orcid.org/0000-0002-8940-038X, Bislimovska, Jovanka, Bousquet, Jean; https://orcid.org/0000-0002-4061-4766, Brockow, Knut; https://orcid.org/0000-0002-2775-3681, Bush, Andrew; https://orcid.org/0000-0001-6756-9822, Cianferoni, Antonella; https://orcid.org/0000-0002-2966-2564, Cork, Michael J; https://orcid.org/0000-0003-4428-2428, Custovic, Adnan; https://orcid.org/0000-0001-5218-7071, Darsow, Ulf, de Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano; https://orcid.org/0000-0002-4517-1749, Deschildre, Antoine; https://orcid.org/0000-0003-2006-7221, Dunn Galvin, Audrey, Ebisawa, Motohiro; https://orcid.org/0000-0003-4117-558X, Fernández‐Rivas, Montserrat; https://orcid.org/0000-0003-1748-2328, Ferrer, Marta; https://orcid.org/0000-0001-8495-1302, Fiocchi, Alessandro; https://orcid.org/0000-0002-2549-0523, Gerth van Wijk, Roy; https://orcid.org/0000-0002-9608-8742, et al, Zuberbier, Torsten; https://orcid.org/0000-0002-1466-8875, Dörr, Tamara, Aberer, Werner, Alvaro, Montserrat; https://orcid.org/0000-0002-5528-8043, Angier, Elizabeth, Arasi, Stefania; https://orcid.org/0000-0002-8135-0568, Arshad, Hasan; https://orcid.org/0000-0001-5988-235X, Ballmer-Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Bartra, Joan; https://orcid.org/0000-0001-7767-4730, Beck, Lisa; https://orcid.org/0000-0002-8452-667X, Bégin, Philippe; https://orcid.org/0000-0002-9089-4604, Bindslev‐Jensen, Carsten; https://orcid.org/0000-0002-8940-038X, Bislimovska, Jovanka, Bousquet, Jean; https://orcid.org/0000-0002-4061-4766, Brockow, Knut; https://orcid.org/0000-0002-2775-3681, Bush, Andrew; https://orcid.org/0000-0001-6756-9822, Cianferoni, Antonella; https://orcid.org/0000-0002-2966-2564, Cork, Michael J; https://orcid.org/0000-0003-4428-2428, Custovic, Adnan; https://orcid.org/0000-0001-5218-7071, Darsow, Ulf, de Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano; https://orcid.org/0000-0002-4517-1749, Deschildre, Antoine; https://orcid.org/0000-0003-2006-7221, Dunn Galvin, Audrey, Ebisawa, Motohiro; https://orcid.org/0000-0003-4117-558X, Fernández‐Rivas, Montserrat; https://orcid.org/0000-0003-1748-2328, Ferrer, Marta; https://orcid.org/0000-0001-8495-1302, Fiocchi, Alessandro; https://orcid.org/0000-0002-2549-0523, Gerth van Wijk, Roy; https://orcid.org/0000-0002-9608-8742, and et al

Published
2022

12. Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food—A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA²LEN position paper

Author

Zuberbier, Torsten, Dörr, Tamara, Aberer, Werner, Alvaro, Montserrat, Angier, Elizabeth, Arasi, Stefania, Arshad, Hasan, Ballmer-Weber, Barbara, Bartra, Joan, Beck, Lisa, Bégin, Philippe, Bindslev‐Jensen, Carsten, Bislimovska, Jovanka, Bousquet, Jean, Brockow, Knut, Bush, Andrew, Cianferoni, Antonella, Cork, Michael J, Custovic, Adnan, Darsow, Ulf, de Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano, Deschildre, Antoine, Dunn Galvin, Audrey, Ebisawa, Motohiro, Fernández‐Rivas, Montserrat, Ferrer, Marta, Fiocchi, Alessandro, Gerth van Wijk, Roy, et al, University of Zurich, and Zuberbier, Torsten

Subjects
2403 Immunology, Immunology, 2723 Immunology and Allergy, 10177 Dermatology Clinic, Immunology and Allergy, 610 Medicine & health
Published
2022
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13. Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food—A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA²LEN position paper

Author

Zuberbier, Torsten, primary, Dörr, Tamara, additional, Aberer, Werner, additional, Alvaro, Montserrat, additional, Angier, Elizabeth, additional, Arasi, Stefania, additional, Arshad, Hasan, additional, Ballmer‐Weber, Barbara, additional, Bartra, Joan, additional, Beck, Lisa, additional, Bégin, Philippe, additional, Bindslev‐Jensen, Carsten, additional, Bislimovska, Jovanka, additional, Bousquet, Jean, additional, Brockow, Knut, additional, Bush, Andrew, additional, Cianferoni, Antonella, additional, Cork, Michael J., additional, Custovic, Adnan, additional, Darsow, Ulf, additional, Jong, Nicolette, additional, Deleanu, Diana, additional, Del Giacco, Stefano, additional, Deschildre, Antoine, additional, Dunn Galvin, Audrey, additional, Ebisawa, Motohiro, additional, Fernández‐Rivas, Montserrat, additional, Ferrer, Marta, additional, Fiocchi, Alessandro, additional, Gerth van Wijk, Roy, additional, Gotua, Maia, additional, Grimshaw, Kate, additional, Grünhagen, Josefine, additional, Heffler, Enrico, additional, Hide, Michihiro, additional, Hoffmann‐Sommergruber, Karin, additional, Incorvaia, Cristoforo, additional, Janson, Christer, additional, Malte John, Swen, additional, Jones, Carla, additional, Jutel, Marek, additional, Katoh, Norito, additional, Kendziora, Benjamin, additional, Kinaciyan, Tamar, additional, Knol, Edward, additional, Kurbacheva, Oksana, additional, Lau, Susanne, additional, Loh, Richard, additional, Lombardi, Carlo, additional, Mäkelä, Mika, additional, Marchisotto, Mary Jane, additional, Makris, Michael, additional, Maurer, Marcus, additional, Meyer, Rosan, additional, Mijakoski, Dragan, additional, Minov, Jordan, additional, Mullol, Joaquim, additional, Nilsson, Caroline, additional, Nowak–Wegrzyn, Anna, additional, Nwaru, Bright I., additional, Odemyr, Mikela, additional, Pajno, Giovanni Battista, additional, Paudel, Sushil, additional, Papadopoulos, Nikolaos G., additional, Renz, Harald, additional, Ricci, Giampaolo, additional, Ring, Johannes, additional, Rogala, Barbara, additional, Sampson, Hugh, additional, Senna, Gianenrico, additional, Sitkauskiene, Brigita, additional, Smith, Peter Kenneth, additional, Stevanovic, Katarina, additional, Stoleski, Sasho, additional, Szajewska, Hania, additional, Tanaka, Akio, additional, Todo‐Bom, Ana, additional, Topal, Fatih Alexander, additional, Valovirta, Erkka, additional, Van Ree, Ronald, additional, Venter, Carina, additional, Wöhrl, Stefan, additional, Wong, Gary W.K., additional, Zhao, Zuotao, additional, and Worm, Margitta, additional

Published
2021
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14. In-vivo Untersuchungen zur molekularen Wirkungsweise von thermomechanischer Ablation an der Haut

Author

Dörr, Tamara Kathrin

Subjects
thermomechanical ablation, growth factors, microinvasive skin resurfacing, wound healing, cytokines, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

Hintergrund Minimalinvasive Techniken, die durch Induktion der Kollagenneubildung eine Verbesserung der Hautstruktur bewirken, finden zunehmend Anwendung. Durch Reduktion der Wundheilungsdauer und Nebenwirkungsraten haben neue fraktionierte Verfahren wie fraktioniert-ablative Laser oder die kürzlich eingeführte thermomechanische Ablation (TMA) die klassischen ablativen Laser als Goldstandard abgelöst. Die molekularen Effekte dieser Techniken sind kaum untersucht, für die individualisierte Auswahl der Verfahren sowie für deren prospektive Nutzung in der transdermalen Wirkstoffapplikation ist deren Kenntnis jedoch essentiell. In der vorliegenden Arbeit werden die grundlegenden Wirkmechanismen der TMA untersucht. Methoden TMA (TixelÒ) wurde an 6 gesunden Probanden durchgeführt. 1h und 24h postinterventionem wurde mittels kutaner Mikrodialyse Gewebeflüssigkeit aus den TMAArealen sowie aus Kontrollarealen gewonnen. Mittels LuminexâxMAPâ Technologie wurden die Proben auf Zytokine und Wachstumsfaktoren untersucht. Die Ergebnisauswertung erfolgte als deskriptive Statistik, der Vergleich anhand der Mediane der Gruppen. Unterschiede wurden mittels Wilcoxon-Test statistisch getestet, p-Werte 0.01), während PDGF (+313,3%;p=0.34) erhöht war. Die im adaptiven Immunsystem wirkenden Zytokine IL-2, IL-15 und IL-9 waren nach 24h nicht signifikant hochreguliert. Die Wachstumsfaktoren VEGF-A, HGF, PDGF, BDNF und EGF zeigten eine Hochregulation nach 24h. VEGF-A (78,9%;p, Background Microinvasive skin resurfacing techniques, inducing collagen formation and deposition, are used increasingly in dermatology. Replacing ablative treatments, the current gold standard are modern techniques such as fractionated ablative lasers, radiofrequency, microneedling or the recently induced thermomechanical ablation (TMA). Few studies have investigated the molecular effects of such treatments. Although the general mechanism seems to be the induction of inflammation resulting in dermal collagen deposition there are differences to be noted that may lead to tailored skin rejuvenation approaches in the future. Being a new approach on microinvasive techniques, knowledge of molecular effects of TMA is essential but has not yet been studied. Methods Using TixelÒ, TMA was performed on 6 healthy study subjects. Tissue fluid of treated and control areas was extracted using cutaneous microdialysis 1h and 24h postinterventionem. In a multiplex assay analysis, cytokines and growth factors were quantified using LuminexÒxMAPâ technology. Descriptive statistics, using median comparison, were performed. Wilcoxon-test was chosen for statistical testing, significance was determined as p0.01), PDGF was upregulated (+313,3%;p=0.34). Upregulation of cytokines IL-2, IL-15 and IL-9 modulating adaptive immunity after 24h was not significant. Growth factors VEGF-A, HGF, PDGF, BDNF and EGF were upregulated after 24h. VEGF-A (78,9%;p

Published
2021
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17. Gastritis Can Cause and Trigger Chronic Spontaneous Urticaria Independent of the Presence of <bold>Helicobacter pylori</bold>.

Author

Zheleznov, Semen, Urzhumtseva, Galina, Petrova, Natalia, Sarsaniia, Zhanna, Didkovskii, Nikolai, Dörr, Tamara, and Zuberbier, Torsten

Subjects
GASTRITIS, URTICARIA, HELICOBACTER pylori, INFLAMMATION, GASTROINTESTINAL diseases
Abstract

Background/Aim: In chronic spontaneous urticaria (CSU), Helicobacter pylori (HP) has been discussed as a cause, but it is unknown whether the bacterium itself or concomitant inflammation is causing the urticaria. Our aim was to investigate HP and upper gastrointestinal lesions as signs of inflammation independently of each other in the pathogenesis of CSU. Methods: A total of 36 prospectively enrolled CSU patients from Moscow were investigated by gastroscopy and screened for the presence of HP and/or upper gastrointestinal lesions. Those having a positive result were treated according to the Maastricht III recommended guidelines for eradication therapy, and success was assessed by a follow-up gastroscopy. Simultaneously, the activity of CSU was measured before and after therapy of the gastrointestinal condition. Results: HP was observed in 26 of the 36 patients. Erosions or ulcers were found in 18 of the 36 patients, 14 of whom were also positively tested for HP. There was a significant difference in improvement of urticarial symptoms between those who succeeded in healing the erosions and those who did not succeed (p < 0.01) independent of the presence of HP. No significant difference in symptom relief was observed between those who had successful eradication and those in whom HP eradication failed. Conclusions: Upper gastrointestinal inflammatory disorders can cause CSU and trigger exacerbations independently of HP. This might imply that also in HP-positive patients, urticaria is not based on an immunological reaction against the germ but rather on the underlying inflammation. These findings also strengthen the importance of a gastroenterological workup of patients with CSU. [ABSTRACT FROM AUTHOR]

Published
2018
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18. Colonization with resistant bacteria in hospital employees: an epidemiological surveillance and typing study.

Author

Badinski T, Seiffert SN, Grässli F, Babouee Flury B, Besold U, Betschon E, Biggel M, Brucher A, Cusini A, Dörr T, Egli A, Goppel S, Güsewell S, Keller J, von Kietzell M, Möller JC, Nolte O, Ortner M, Roloff T, Ruetti M, Schlegel M, Seth-Smith HMB, Stephan R, Stocker R, Vuichard-Gysin D, Willi B, Kuster SP, Kahlert CR, and Kohler P

Subjects
Humans, Male, Female, Middle Aged, Cross-Sectional Studies, Adult, Switzerland epidemiology, Anti-Bacterial Agents pharmacology, Health Personnel statistics & numerical data, Whole Genome Sequencing, Risk Factors, Prevalence, Epidemiological Monitoring, Bacterial Proteins genetics, Enterobacteriaceae drug effects, Enterobacteriaceae genetics, Personnel, Hospital, Vancomycin-Resistant Enterococci genetics, Vancomycin-Resistant Enterococci drug effects, Vancomycin-Resistant Enterococci isolation & purification, beta-Lactamases genetics
Abstract

The objective of this study was to determine the prevalence, molecular epidemiology, and risk factors for gut colonization with extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E), carbapenemase-producing Enterobacterales (CPE), and vancomycin-resistant enterococci (VRE) in healthcare workers (HCWs). In September/October 2022, we performed a cross-sectional study among HCW from 14 institutions in Northeastern Switzerland. HCWs reported risk factors for antimicrobial resistance (covering the last 12-24 months) and provided rectal swabs. Swabs were screened for ESBL-E, CPE, and VRE; whole-genome sequencing (WGS) was performed to assess the genetic relatedness. Logistic regression was used to identify occupational and non-occupational risk factors. Among approximately 22,500 employees, 1,209 participated (median age 46 years, 82% female). Prevalences of ESBL-E ( n = 65) and CPE ( n = 1) were 5.4% [95% confidence interval (CI) 4.2-6.8] and 0.1% (95% CI 0.0-0.5), respectively; no VREs were detected. In the multivariable analysis, non-European ethnicity [adjusted odds ratio (aOR) 7.0, 95% CI 1.4-27.3], travel to high-risk countries (aOR 4.9, 95% CI 2.5-9.3), systemic antibiotics (aOR 2.1, 95% CI 1.1-3.7), antibiotic eye drops (aOR 4.7, 95% CI 1.7-11.9), and monthly sushi consumption (aOR 2.4, 95% CI 1.4-4.3) were positively associated with ESBL-E colonization, whereas alcohol consumption (aOR 0.5 per glass/week, 95% CI 0.3-0.9) was negatively associated with ESBL-E colonization. Occupational factors showed no association. Among ESBL- Escherichia coli , ST131 (15 of 61, 25%) and bla CTX-M-15 (37/61; 61%) were most common; one isolate co-harbored bla OXA-244 . WGS data did not show relevant clustering. Occupational exposure is not associated with ESBL-E colonization in HCW. Given the potential public health and antibiotic stewardship implications, the role of sushi consumption and antibiotic eye drops as risk factors should be further elucidated., Competing Interests: The authors declare no conflict of interest.

Published
2024
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19. Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food-A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA²LEN position paper.

Author

Zuberbier T, Dörr T, Aberer W, Alvaro M, Angier E, Arasi S, Arshad H, Ballmer-Weber B, Bartra J, Beck L, Bégin P, Bindslev-Jensen C, Bislimovska J, Bousquet J, Brockow K, Bush A, Cianferoni A, Cork MJ, Custovic A, Darsow U, de Jong N, Deleanu D, Del Giacco S, Deschildre A, Dunn Galvin A, Ebisawa M, Fernández-Rivas M, Ferrer M, Fiocchi A, Gerth van Wijk R, Gotua M, Grimshaw K, Grünhagen J, Heffler E, Hide M, Hoffmann-Sommergruber K, Incorvaia C, Janson C, Malte John S, Jones C, Jutel M, Katoh N, Kendziora B, Kinaciyan T, Knol E, Kurbacheva O, Lau S, Loh R, Lombardi C, Mäkelä M, Marchisotto MJ, Makris M, Maurer M, Meyer R, Mijakoski D, Minov J, Mullol J, Nilsson C, Nowak-Wegrzyn A, Nwaru BI, Odemyr M, Pajno GB, Paudel S, Papadopoulos NG, Renz H, Ricci G, Ring J, Rogala B, Sampson H, Senna G, Sitkauskiene B, Smith PK, Stevanovic K, Stoleski S, Szajewska H, Tanaka A, Todo-Bom A, Topal FA, Valovirta E, Van Ree R, Venter C, Wöhrl S, Wong GWK, Zhao Z, and Worm M

Subjects
Allergens analysis, Animals, Eggs, Food Labeling, Humans, Anaphylaxis diagnosis, Anaphylaxis etiology, Anaphylaxis prevention & control, Food Hypersensitivity diagnosis
Abstract

Background: Food anaphylaxis is commonly elicited by unintentional ingestion of foods containing the allergen above the tolerance threshold level of the individual. While labeling the 14 main allergens used as ingredients in food products is mandatory in the EU, there is no legal definition of declaring potential contaminants. Precautionary allergen labeling such as "may contain traces of" is often used. However, this is unsatisfactory for consumers as they get no information if the contamination is below their personal threshold. In discussions with the food industry and technologists, it was suggested to use a voluntary declaration indicating that all declared contaminants are below a threshold of 0.5 mg protein per 100 g of food. This concentration is known to be below the threshold of most patients, and it can be technically guaranteed in most food production. However, it was also important to assess that in case of accidental ingestion of contaminants below this threshold by highly allergic patients, no fatal anaphylactic reaction could occur. Therefore, we performed a systematic review to assess whether a fatal reaction to 5mg of protein or less has been reported, assuming that a maximum portion size of 1kg of a processed food exceeds any meal and thus gives a sufficient safety margin., Methods: MEDLINE and EMBASE were searched until 24 January 2021 for provocation studies and case reports in which one of the 14 major food allergens was reported to elicit fatal or life-threatening anaphylactic reactions and assessed if these occurred below the ingestion of 5mg of protein. A Delphi process was performed to obtain an expert consensus on the results., Results: In the 210 studies included, in our search, no reports of fatal anaphylactic reactions reported below 5 mg protein ingested were identified. However, in provocation studies and case reports, severe reactions below 5 mg were reported for the following allergens: eggs, fish, lupin, milk, nuts, peanuts, soy, and sesame seeds., Conclusion: Based on the literature studied for this review, it can be stated that cross-contamination of the 14 major food allergens below 0.5 mg/100 g is likely not to endanger most food allergic patients when a standard portion of food is consumed. We propose to use the statement "this product contains the named allergens in the list of ingredients, it may contain traces of other contaminations (to be named, e.g. nut) at concentrations less than 0.5 mg per 100 g of this product" for a voluntary declaration on processed food packages. This level of avoidance of cross-contaminations can be achieved technically for most processed foods, and the statement would be a clear and helpful message to the consumers. However, it is clearly acknowledged that a voluntary declaration is only a first step to a legally binding solution. For this, further research on threshold levels is encouraged., (© 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

Published
2022
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