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1. GraphQL Adoption and Challenges: Community-Driven Insights from StackOverflow Discussions

Author

Amareen, Saleh, Dector, Obed Soto, Dado, Ali, and Bosu, Amiangshu

Subjects
Computer Science - Software Engineering
Abstract

GraphQL is a query language and web application programming interface (API) for client-server architecture. Its advantages include type-safe queries, which allow clients to retrieve the data they require precisely in a single request. As organizations adopt GraphQL for API implementations, it is imperative to understand its challenges and the software community's interests. To achieve this goal, we conducted a five-step mixed-method empirical analysis of 45K StackOverflow questions and answers on GraphQL. In the first step, we derive a reference architecture for the GraphQL ecosystem with five key layers. Second, we used topic modeling based on Latent Dirichlet Allocation (LDA) to automatically identify 14 topics and 47 subtopics. Third, we mapped discussion topics to architecture layers. Fourth, we manually investigate questions on each topic and subtopics to provide additional insight to the GraphQL stakeholders. Finally, we study topic difficulty, popularity, trends, and tradeoffs to provide insights into evolving community interests and challenges. Our results indicate that Client and Server are the top two architectural layers attracting discussion on SO. While earlier discussions on SO focused on building third-party applications consuming GraphQL APIs (i.e., API Integration) released by large organizations, recent trends suggest more organizations implementing APIs using GraphQL servers. Due to difficulty and lack of well-defined solutions, security remains a difficult and low-interest area. However, such a practice can lead to vulnerable APIs.

Published
2024

4. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis

Author

Rios, Fernando, Van Haren, Frank, Sottiaux, T, Lora, Fredy S, Azevedo, Luciano C, Depuydt, P, Fan, Eddy, Bugedo, Guillermo, Qiu, Haibo, Gonzalez, Marcos, Silesky, Juan, Cerny, Vladimir, Nielsen, Jonas, Jibaja, Manuel, Pham, Tài, Wrigge, Hermann, Matamis, Dimitrios, Ranero, Jorge Luis, Hashemian, S. M, Amin, Pravin, Clarkson, Kevin, Bellani, Giacomo, Kurahashi, Kiyoyasu, Villagomez, Asisclo, Zeggwagh, Amine Ali, Heunks, Leo M, Laake, Jon Henrik, Palo, Jose Emmanuel, do Vale Fernandes, Antero, Sandesc, Dorel, Arabi, Yaasen, Bumbasierevic, Vesna, Nin, Nicolas, Lorente, Jose A, Larsson, Anders, Piquilloud, Lise, Abroug, Fekri, McAuley, Daniel F, McNamee, Lia, Hurtado, Javier, Bajwa, Ed, Démpaire, Gabriel, Francois, Guy M, Sula, Hektor, Nunci, Lordian, Cani, Alma, Zazu, Alan, Dellera, Christian, Insaurralde, Carolina S, Alejandro, Risso V, Daldin, Julio, Vinzio, Mauricio, Fernandez, Ruben O, Cardonnet, Luis P, Bettini, Lisandro R, Bisso, Mariano Carboni, Osman, Emilio M, Setten, Mariano G, Lovazzano, Pablo, Alvarez, Javier, Villar, Veronica, Milstein, Cesar, Pozo, Norberto C, Grubissich, Nicolas, Plotnikow, Gustavo A, Vasquez, Daniela N, Ilutovich, Santiago, Tiribelli, Norberto, Chena, Ariel, Pellegrini, Carlos A, Saenz, María G, Estenssoro, Elisa, Brizuela, Matias, Gianinetto, Hernan, Gomez, Pablo E, Cerrato, Valeria I, Bezzi, Marco G, Borello, Silvina A, Loiacono, Flavia A, Fernandez, Adriana M, Knowles, Serena, Reynolds, Claire, Inskip, Deborah M, Miller, Jennene J, Kong, Jing, Whitehead, Christina, Bihari, Shailesh, Seven, Aylin, Krstevski, Amanda, Rodgers, Helen J, Millar, Rebecca T, Mckenna, Toni E, Bailey, Irene M, Hanlon, Gabrielle C, Aneman, Anders, Lynch, Joan M, Azad, Raman, Neal, John, Woods, Paul W, Roberts, Brigit L, Kol, Mark R, Wong, Helen S, Riss, Katharina C, Staudinger, Thomas, Wittebole, Xavier, Berghe, Caroline, Bulpa, Pierre A, Dive, Alain M, Verstraete, Rik, Lebbinck, Herve, Depuydt, Pieter, Vermassen, Joris, Meersseman, Philippe, Ceunen, Helga, Rosa, Jonas I, Beraldo, Daniel O, Piras, Claudio, Ampinelli, Adenilton M R, Nassar Jr, Antonio P, Mataloun, Sergio, Moock, Marcelo, Thompson, Marlus M, Gonçalves, Claudio H, Antônio, Ana Carolina P, Ascoli, Aline, Biondi, Rodrigo S, Fontenele, Danielle C, Nobrega, Danielle, Sales, Vanessa M, Shindhe, Suresh, Ismail, Dk Maizatul Aiman B Pg Hj, Laffey, John, Beloncle, Francois, Davies, Kyle G, Cirone, Rob, Manoharan, Venika, Ismail, Mehvish, Goligher, Ewan C, Jassal, Mandeep, Nishikawa, Erin, Javeed, Areej, Curley, Gerard, Rittayamai, Nuttapol, Parotto, Matteo, Ferguson, Niall D, Mehta, Sangeeta, Knoll, Jenny, Pronovost, Antoine, Canestrini, Sergio, Bruhn, Alejandro R, Garcia, Patricio H, Aliaga, Felipe A, Farías, Pamela A, Yumha, Jacob S, Ortiz, Claudia A, Salas, Javier E, Saez, Alejandro A, Vega, Luis D, Labarca, Eduardo F, Martinez, Felipe T, Carreño, Nicolás G, Lora, Pilar, Liu, Haitao, Liu, Ling, Tang, Rui, Luo, Xiaoming, An, Youzhong, Zhao, Huiying, Gao, Yan, Zhai, Zhe, Ye, Zheng L, Wang, Wei, Li, Wenwen, Li, Qingdong, Zheng, Ruiqiang, Yu, Wenkui, Shen, Juanhong, Li, Xinyu, Yu, Tao, Lu, Weihua, Wu, Ya Q, Huang, Xiao B, He, Zhenyang, Lu, Yuanhua, Han, Hui, Zhang, Fan, Sun, Renhua, Wang, Hua X, Qin, Shu H, Zhu, Bao H, Zhao, Jun, Liu, Jian, Li, Bin, Liu, Jing L, Zhou, Fa C, Li, Qiong J, Zhang, Xing Y, Li-Xin, Zhou, Xin-Hua, Qiang, Jiang, Liangyan, Gao, Yuan N, Zhao, Xian Y, Li, Yuan Y, Li, Xiao L, Wang, Chunting, Yao, Qingchun, Yu, Rongguo, Chen, Kai, Shao, Huanzhang, Qin, Bingyu, Huang, Qing Q, Zhu, Wei H, Hang, Ai Y, Hua, Ma X, Li, Yimin, Xu, Yonghao, Di, Yu D, Ling, Long L, Qin, Tie H, Wang, Shou H, Qin, Junping, Han, Yi, Zhou, Suming, Vargas, Monica P, Silesky Jimenez, Juan I, González Rojas, Manuel A, Solis-Quesada, Jaime E, Ramirez-Alfaro, Christian M, Máca, Jan, Sklienka, Peter, Gjedsted, Jakob, Christiansen, Aage, Villamagua, Boris G, Llano, Miguel, Burtin, Philippe, Buzancais, Gautier, Beuret, Pascal, Pelletier, Nicolas, Mortaza, Satar, Mercat, Alain, Chelly, Jonathan, Jochmans, Sébastien, Terzi, Nicolas, Daubin, Cédric, Carteaux, Guillaume, de Prost, Nicolas, Chiche, Jean-Daniel, Daviaud, Fabrice, Pham, Tai, Fartoukh, Muriel, Barberet, Guillaume, Biehler, Jerome, Dellamonica, Jean, Doyen, Denis, Arnal, Jean-Michel, Briquet, Anais, Hraiech, Sami, Papazian, Laurent, Follin, Arnaud, Roux, Damien, Messika, Jonathan, Kalaitzis, Evangelos, Dangers, Laurence, Combes, Alain, Au, Siu-Ming, Béduneau, Gaetan, Carpentier, Dorothée, Zogheib, Elie H, Dupont, Herve, Ricome, Sylvie, Santoli, Francesco L, Besset, Sebastien L, Michel, Philippe, Gelée, Bruno, Danin, Pierre-Eric, Goubaux, Bernard, Crova, Philippe J, Phan, Nga T, Berkelmans, Frantz, Badie, Julio C, Tapponnier, Romain, Gally, Josette, Khebbeb, Samy, Herbrecht, Jean-Etienne, Schneider, Francis, Declercq, Pierre-Louis M, Rigaud, Jean-Philippe, Duranteau, Jacques, Harrois, Anatole, Chabanne, Russell, Marin, Julien, Bigot, Charlene, Thibault, Sandrine, Ghazi, Mohammed, Boukhazna, Messabi, Ould Zein, Salem, Richecoeur, Jack R, Combaux, Daniele M, Grelon, Fabien, Le Moal, Charlene, Sauvadet, Elise P, Robine, Adrien, Lemiale, Virginie, Reuter, Danielle, Dres, Martin, Demoule, Alexandre, Goldgran-Toledano, Dany, Baboi, Loredana, Guérin, Claude, Lohner, Ralph, Kraßler, Jens, Schäfer, Susanne, Zacharowski, Kai D, Meybohm, Patrick, Reske, Andreas W, Simon, Philipp, Hopf, Hans-Bernd F, Schuetz, Michael, Baltus, Thomas, Papanikolaou, Metaxia N, Papavasilopoulou, Theonymfi G, Zacharas, Giannis A, Ourailogloy, Vasilis, Mouloudi, Eleni K, Massa, Eleni V, Nagy, Eva O, Stamou, Electra E, Kiourtzieva, Ellada V, Oikonomou, Marina A, Avila, Luis E, Cortez, Cesar A, Citalán, Johanna E, Jog, Sameer A, Sable, Safal D, Shah, Bhagyesh, Gurjar, Mohan, Baronia, Arvind K, Memon, Mohammedfaruk, Muthuchellappan, Radhakrishnan, Ramesh, Venkatapura J, Shenoy, Anitha, Unnikrishnan, Ramesh, Dixit, Subhal B, Rhayakar, Rachana V, Ramakrishnan, Nagarajan, Bhardwaj, Vallish K, Mahto, Heera L, Sagar, Sudha V, Palaniswamy, Vijayanand, Ganesan, Deeban, Mohammadreza Hashemian, Seyed, Jamaati, Hamidreza, Heidari, Farshad, Meaney, Edel A, Nichol, Alistair, Knapman, Karl M, O'Croinin, Donall, Dunne, Eimhin S, Breen, Dorothy M, Clarkson, Kevin P, Jaafar, Rola F, Dwyer, Rory, Amir, Fahd, Ajetunmobi, Olaitan O, O'Muircheartaigh, Aogan C, Black, Colin S, Treanor, Nuala, Collins, Daniel V, Altaf, Wahid, Zani, Gianluca, Fusari, Maurizio, Spadaro, Savino, Volta, Carlo A, Graziani, Romano, Brunettini, Barbara, Palmese, Salvatore, Formenti, Paolo, Umbrello, Michele, Lombardo, Andrea, Pecci, Elisabetta, Botteri, Marco, Savioli, Monica, Protti, Alessandro, Mattei, Alessia, Schiavoni, Lorenzo, Tinnirello, Andrea, Todeschini, Manuel, Giarratano, Antonino, Cortegiani, Andrea, Sher, Sara, Rossi, Anna, Antonelli, Massimo M, Montini, Luca M, Casalena, Paolo, Scafetti, Sergio, Panarello, Giovanna, Occhipinti, Giovanna, Patroniti, Nicolò, Pozzi, Matteo, Biscione, Roberto R, Poli, Michela M, Raimondi, Ferdinando, Albiero, Daniela, Crapelli, Giulia, Beck, Eduardo, Pota, Vincenzo, Schiavone, Vincenzo, Molin, Alexandre, Tarantino, Fabio, Monti, Giacomo, Frati, Elena, Mirabella, Lucia, Cinnella, Gilda, Fossali, Tommaso, Colombo, Riccardo, Terragni, Pierpaolo, Pattarino, Ilaria, Mojoli, Francesco, Braschi, Antonio, Borotto, Erika E, Cracchiolo, Andrea N, Palma, Daniela M, Raponi, Francesco, Foti, Giuseppe, Vascotto, Ettore R, Coppadoro, Andrea, Brazzi, Luca, Floris, Leda, Iotti, Giorgio A, Venti, Aaron, Yamaguchi, Osamu, Takagi, Shunsuke, Maeyama, Hiroki N, Watanabe, Eizo, Yamaji, Yoshihiro, Shimizu, Kazuyoshi, Shiozaki, Kyoko, Futami, Satoru, Ryosuke, Sekine, Saito, Koji, Kameyama, Yoshinobu, Ueno, Keiko, Izawa, Masayo, Okuda, Nao, Suzuki, Hiroyuki, Harasawa, Tomofumi, Nasu, Michitaka, Takada, Tadaaki, Ito, Fumihito, Nunomiya, Shin, Koyama, Kansuke, Abe, Toshikazu, Andoh, Kohkichi, Kusumoto, Kohei, Hirata, Akira, Takaba, Akihiro, Kimura, Hiroyasu, Matsumoto, Shuhei, Higashijima, Ushio, Honda, Hiroyuki, Aoki, Nobumasa, Imai, Hiroshi, Ogino, Yasuaki, Mizuguchi, Ichiko, Ichikado, Kazuya, Nitta, Kenichi, Mochizuki, Katsunori, Hashida, Tomoaki, Tanaka, Hiroyuki, Nakamura, Tomoyuki, Niimi, Daisuke, Ueda, Takeshi, Kashiwa, Yozo, Uchiyama, Akinori, Sabelnikovs, Olegs, Oss, Peteris, Haddad, Youssef, Liew, Kong Y, Ñamendys-Silva, Silvio A, Jarquin-Badiola, Yves D, Sanchez-Hurtado, Luis A, Gomez-Flores, Saira S, Marin, Maria C, Villagomez, Asisclo J, Lemus, Jordana S, Fierro, Jonathan M, Cervantes, Mavy Ramirez, Mejia, Francisco Javier Flores, Gonzalez, Daniel R, Dector, Dulce M, Estrella, Claudia R, Sanchez-Medina, Jorge R, Ramirez-Gutierrez, Alvaro, George, Fernando G, Aguirre, Janet S, Buensuseso, Juan A, Poblano, Manuel, Dendane, Tarek, Balkhi, Hicham, Elkhayari, Mina, Samkaoui, Nacer, Ezzouine, Hanane, Benslama, Abdellatif, Amor, Mourad, Maazouzi, Wajdi, Cimic, Nedim, Beck, Oliver, Bruns, Monique M, Schouten, Jeroen A, Rinia, Myra, Raaijmakers, Monique, Van Wezel, Hellen M, Heines, Serge J, Buise, Marc P, Simonis, Fabienne D, Schultz, Marcus J, Goodson, Jennifer C, rowne, Troy S B, Navarra, Leanlove, Hunt, Anna, Hutchison, Robyn A, Bailey, Mathew B, Newby, Lynette, Mcarthur, Colin, Kalkoff, Michael, Mcleod, Alex, Casement, Jonathan, Hacking, Danielle J, Andersen, Finn H, Dolva, Merete S, Laake, Jon H, Barratt-Due, Andreas, Noremark, Kim Andre L, Søreide, Eldar, Sjøbø, Brit Å, Guttormsen, Anne B, Yoshido, Hector H Leon, Aguilar, Ronald Zumaran, Oscanoa, Fredy A Montes, Alisasis, Alain U, Robles, Joanne B, Pasanting-Lim, Rossini Abbie B, Tan, Beatriz C, Andruszkiewicz, Pawel, Jakubowska, Karina, Cox, Cristina M, Alvarez, António M, Oliveira, Bruno S, Montanha, Gustavo M, Barros, Nelson C, Pereira, Carlos S, Messias, António M, Monteiro, Jorge M, Araujo, Ana M, Catorze, Nuno T, Marum, Susan M, Bouw, Maria J, Gomes, Rui M, Brito, Vania A, Castro, Silvia, Estilita, Joana M, Barros, Filipa M, Serra, Isabel M, Martinho, Aurelia M, Tomescu, Dana R, Marcu, Alexandra, Bedreag, Ovidiu H, Papurica, Marius, Corneci, Dan E, Negoita, Silvius Ioan, Grigoriev, Evgeny, Gritsan, Alexey I, Gazenkampf, Andrey A, Almekhlafi, Ghaleb, Albarrak, Mohamad M, Mustafa, Ghanem M, Maghrabi, Khalid A, Salahuddin, Nawal, Aisa, Tharwat M, Al Jabbary, Ahmed S, Tabhan, Edgardo, Arabi, Yaseen M, Trinidad, Olivia A, Al Dorzi, Hasan M, Tabhan, Edgardo E, Bolon, Stefan, Smith, Oliver, Mancebo, Jordi, Aguirre-Bermeo, Hernan, Lopez-Delgado, Juan C, Esteve, Francisco, Rialp, Gemma, Forteza, Catalina, De Haro, Candelaria, Artigas, Antonio, Albaiceta, Guillermo M, De Cima-Iglesias, Sara, Seoane-Quiroga, Leticia, Ceniceros-Barros, Alexandra, Ruiz-Aguilar, Antonio L, Claraco-Vega, Luis M, Soler, Juan Alfonso, Lorente, Maria del Carmen, Hermosa, Cecilia, Gordo, Federico, Prieto-González, Miryam, López-Messa, Juan B, Perez, Manuel P, Pere, Cesar P, Allue, Raquel Montoiro, Roche-Campo, Ferran, Ibañez-Santacruz, Marcos, Temprano, Susana, Pintado, Maria C, De Pablo, Raul, Gómez, Pilar Ricart Aroa, Ruiz, Silvia Rodriguez, Moles, Silvia Iglesias, Jurado, Mª Teresa, Arizmendi, Alfons, Piacentini, Enrique A, Franco, Nieves, Honrubia, Teresa, Perez Cheng, Meisy, Perez Losada, Elena, Blanco, Javier, Yuste, Luis J, Carbayo-Gorriz, Cecilia, Cazorla-Barranquero, Francisca G, Alonso, Javier G, Alda, Rosa S, Algaba, Ángela, Navarro, Gonzalo, Cereijo, Enrique, Diaz-Rodriguez, Esther, Marcos, Diego Pastor, Montero, Laura Alvarez, Para, Luis Herrera, Sanchez, Roberto Jimenez, Blasco Navalpotro, Miguel Angel, Abad, Ricardo Diaz, Montiel González, Raquel, Toribio, Dácil Parrilla, Castro, Alejandro G, Artiga, Maria Jose D, Penuelas, Oscar, Roser, Tomas P, Olga, Moreno F, Curto, Elena Gallego, Sánchez, Rocío Manzano, Imma, Vallverdu P, Elisabet, Garcia M, Claverias, Laura, Magret, Monica, Pellicer, Ana M, Rodriguez, Lucia L, Sánchez-Ballesteros, Jesús, González-Salamanca, Ángela, Jimenez, Antonio G, Huerta, Francisco P, Diaz, Juan Carlos J Sotillo, Lopez, Esther Bermejo, Moya, David D Llinares, Alfonso, Alec A Tallet, Eugenio Luis, Palazon Sanchez, Cesar, Palazon Sanchez, Rafael, Sánchez I, Virgilio, Corcoles G, Recio, Noelia N, Adamsson, Richard O, Rylander, Christian C, Holzgraefe, Bernhard, Broman, Lars M, Wessbergh, Joanna, Persson, Linnea, Schiöler, Fredrik, Kedelv, Hans, Tibblin, Anna Oscarsson, Appelberg, Henrik, Hedlund, Lars, Helleberg, Johan, Eriksson, Karin E, Glietsch, Rita, Larsson, Niklas, Nygren, Ingela, Nunes, Silvia L, Morin, Anna-Karin, Kander, Thomas, Adolfsson, Anne, Zender, Hervé O., Leemann-Refondini, Corinne, Elatrous, Souheil, Bouchoucha, Slaheddine, Chouchene, Imed, Ouanes, Islem, Ben Souissi, Asma, Kamoun, Salma, Demirkiran, Oktay, Aker, Mustafa, Erbabacan, Emre, Ceylan, Ilkay, Girgin, Nermin Kelebek, Ozcelik, Menekse, Ünal, Necmettin, Meco, Basak Ceyda, Akyol, Onat O, Derman, Suleyman S, Kennedy, Barry, Parhar, Ken, Srinivasa, Latha, McAuley, Danny, Steinberg, Jack, Hopkins, Phil, Mellis, Clare, Stansil, Frank, Kakar, Vivek, Hadfield, Dan, Brown, Christine, Vercueil, Andre, Bhowmick, Kaushik, Humphreys, Sally K, Ferguson, Andrew, Mckee, Raymond, Raj, Ashok S, Fawkes, Danielle A, Watt, Philip, Twohey, Linda, Thomas, Rajeev R Jha Matthew, Morton, Alex, Kadaba, Varsha, Smith, Mark J, Hormis, Anil P, Kannan, Santhana G, Namih, Miriam, Reschreiter, Henrik, Camsooksai, Julie, Kumar, Alek, Rugonfalvi, Szabolcs, Nutt, Christopher, Oneill, Orla, Seasman, Colette, Dempsey, Ged, Scott, Christopher J, Ellis, Helen E, Mckechnie, Stuart, Hutton, Paula J, Di Tomasso, Nora N, Vitale, Michela N, Griffin, Ruth O, Dean, Michael N, Cranshaw, Julius H, Willett, Emma L, Ioannou, Nicholas, Gillis, Sarah, Csabi, Peter, Macfadyen, Rosaleen, Dawson, Heidi, Preez, Pieter D, Williams, Alexandra J, Boyd, Owen, De Gordoa, Laura Ortiz-Ruiz, Bramall, Jon, Symmonds, Sophie, Chau, Simon K, Wenham, Tim, Szakmany, Tamas, Toth-Tarsoly, Piroska, Mccalman, Katie H, Alexander, Peter, Stephenson, Lorraine, Collyer, Thomas, Chapman, Rhiannon, Cooper, Raphael, Allan, Russell M, Sim, Malcolm, Wrathall, David W, Irvine, Donald A, Zantua, Kim S, Adams, John C, Burtenshaw, Andrew J, Sellors, Gareth P, Welters, Ingeborg D, Williams, Karen E, Hessell, Robert J, Oldroyd, Matthew G, Battle, Ceri E, Pillai, Suresh, Kajtor, Istvan, Sivashanmugave, Mageswaran, Okane, Sinead C, Donnelly, Adrian, Frigyik, Aniko D, Careless, Jon P, May, Martin M, Stewart, Richard, Trinder, T John, Hagan, Samantha J, Wise, Matt P, Cole, Jade M, MacFie, Caroline C, Dowling, Anna T, Nuñez, Edgardo, Pittini, Gustavo, Rodriguez, Ruben, Imperio, María C, Santos, Cristina, França, Ana G., Ebeid, Alejandro, Deicas, Alberto, Serra, Carolina, Uppalapati, Aditya, Kamel, Ghassan, Banner-Goodspeed, Valerie M, Beitler, Jeremy R, Mukkera, Satyanarayana Reddy, Kulkarni, Shreedhar, Lee, Jarone, Mesar, Tomaz, Shinn Iii, John O, Gomaa, Dina, Tainter, Christopher, Cowley, R Adams, Yeatts, Dale J, Warren, Jessica, Lanspa, Michael J, Miller, Russel R, Grissom, Colin K, Brown, Samuel M, Bauer, Philippe R, Gosselin, Ryan J, Kitch, Barrett T, Cohen, Jason E, Beegle, Scott H, Gueret, Renaud M, Tulaimat, Aiman, Choudry, Shazia, Stigler, William, Batra, Hitesh, Huff, Nidhi G, Lamb, Keith D, Oetting, Trevor W, Mohr, Nicholas M, Judy, Claine, Saito, Shigeki, Kheir, Fayez M, Schlichting, Adam B, Delsing, Angela, Elmasri, Mary, Crouch, Daniel R, Ismail, Dina, Blakeman, Thomas C, Dreyer, Kyle R, Baron, Rebecca M, Grijalba, Carolina Quintana, Hou, Peter C, Seethala, Raghu, Aisiku, Imo, Henderson, Galen, Frendl, Gyorgy, Hou, Sen-Kuang, Owens, Robert L, Schomer, Ashley, Bumbasirevic, Vesna, Jovanovic, Bojan, Surbatovic, Maja, Veljovic, Milic, Maddali, Manoj V, Churpek, Matthew, Rezoagli, Emanuele, Zhuo, Hanjing, Zhao, Wendi, He, June, Delucchi, Kevin L, Wang, Chunxue, Wickersham, Nancy, McNeil, J Brennan, Jauregui, Alejandra, Ke, Serena, Vessel, Kathryn, Gomez, Antonio, Hendrickson, Carolyn M, Kangelaris, Kirsten N, Sarma, Aartik, Leligdowicz, Aleksandra, Liu, Kathleen D, Matthay, Michael A, Ware, Lorraine B, Laffey, John G, Calfee, Carolyn S, and Sinha, Pratik

Published
2022
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5. Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Author

Martinez, Amadeu, Leal, Livia, Jorge Pereira, Antonio, de Oliveira Maia, Marcelo, Neto, Josè Aires, Piras, Claudio, Caser, Eliana Bernadete, Moreira, Cora Lavigne, Braga Gusman, Pablo, Dalcomune, Dyanne Moysés, Ribeiro de Carvalho, Alexandre Guilherme, Gondim, Louise Aline Romão, Castelo Branco Reis, Lívia Mariane, da Cunha Ribeiro, Daniel, de Assis Simões, Leonardo, Campos, Rafaela Siqueira, Fernandez Versiani dos Anjos, José Carlos, Bruzzi Carvalho, Frederico, Alves, Rossine Ambrosio, Nunes, Lilian Batista, Réa-Neto, Álvaro, de Oliveira, Mirella Cristine, Tannous, Luana, Cardoso Gomes, Brenno, Rodriguez, Fernando Borges, Abelha, Priscila, Lugarinho, Marcelo E, Japiassu, Andre, de Melo, Hélder Konrad, Lopes, Elton Afonso, Varaschin, Pedro, de Souza Dantas, Vicente Cés, Freitas Knibel, Marcos, Ponte, Micheli, de Azambuja Rodrigues, Pedro Mendes, Costa Filho, Rubens Carmo, Saddy, Felipe, Wanderley Castellões, Théia Forny, Silva, Suzana Alves, Osorio, Luiz Antonio Gomes, Mannarino, Dora, Espinoza, Rodolfo, Righy, Cassia, Soares, Marcio, Salluh, Jorge, Tanaka, Lilian, Aragão, Daniel, Tavares, Maria Eduarda, Kehdi, Maura Goncalves Pereira, Rezende, Valéria Maria Campos, Carbonell, Roberto Carlos Cruz, Teixeira, Cassiano, de Oliveira, Roselaine Pinheiro, Maccari, Juçara Gasparetto, Castro, Priscylla Souza, Berto, Paula, Schwarz, Patricia, Torelly, André Peretti, Lisboa, Thiago, Moraes, Edison, Dal-Pizzol, Felipe, Tomasi Damiani, Cristiane, Ritter, Cristiane, Ferreira, Juliana Carvalho, Teixeira Costa, Ramon, Caruso, Pedro, Amendola, Cristina Prata, de Oliveira, Amanda Maria R R, Silva, Ulysses V A, Sanches, Luciana Coelho, Almeida, Rosana D S, Azevedo, Luciano Cesar, Park, Marcelo, Schettino, Guilherme, Assunção, Murillo Santucci, Silva, Eliezer, Barboza, Carlos Eduardo, Junior, Antonio Paulo Nassar, Marzocchi Tierno, Paulo Fernando G M, Malbouisson, Luis Marcelo, Oliveira, Lucas, Cristovao, Davi, Neto, Manoel Leitão, Rego, Ênio, Fernandes, Fernanda Eugênia, Romano, Marcelo Luz Pereira, Cavalcanti, Alexandre Biasi, de Souza Barros, Dalton, Suzumura, Érica Aranha, Meira, Karla Loureiro, de Oliveira, Gustavo Affonso, Luciano, Paula Menezes, Pacheco, Evelin Drociunas, Mazza, Bruno Franco, Machado, Flavia Ribeiro, Ferreira, Elaine, dos Santos, Ronaldo Batista, Colombo, Alexandra Siqueira, Nogueira, Antonio Carlos, Fernandes, Juliana Baroni, Nóbrega, Raquel Siqueira, do CS Martins, Barbara, Soriano, Francisco, Morsch, Rafaela Deczka, Nunes, Andre Luiz Baptiston, de Almeida, Juliano Pinheiro, Hajjar, Ludhmila, Moulin, Sílvia, Giannini, Fábio Poianas, Baptiston Nunes, Andre Luiz, Rios, Fernando, Van Haren, Frank, Sottiaux, T, Lora, Fredy S, Azevedo, Luciano C, Depuydt, P, Fan, Eddy, Bugedo, Guillermo, Qiu, Haibo, Gonzalez, Marcos, Silesky, Juan, Cerny, Vladimir, Nielsen, Jonas, Jibaja, Manuel, Pham, Tài, Wrigge, Hermann, Matamis, Dimitrios, Ranero, Jorge Luis, Hashemian, S M, Amin, Pravin, Clarkson, Kevin, Bellani, Giacomo, Kurahashi, Kiyoyasu, Villagomez, Asisclo, Zeggwagh, Amine Ali, Heunks, Leo M, Laake, Jon Henrik, Palo, Jose Emmanuel, do Vale Fernandes, Antero, Sandesc, Dorel, Arabi, Yaasen, Bumbasierevic, Vesna, Lorente, Jose A, Larsson, Anders, Piquilloud, Lise, Abroug, Fekri, McAuley, Daniel F, McNamee, Lia, Hurtado, Javier, Bajwa, Ed, Démpaire, Gabriel, Francois, Guy M, Sula, Hektor, Nunci, Lordian, Cani, Alma, Zazu, Alan, Dellera, Christian, Insaurralde, Carolina S, Alejandro, Risso V, Daldin, Julio, Vinzio, Mauricio, Fernandez, Ruben O, Cardonnet, Luis P, Bettini, Lisandro R, Bisso, Mariano Carboni, Osman, Emilio M, Setten, Mariano G, Lovazzano, Pablo, Alvarez, Javier, Villar, Veronica, Milstein, Cesar, Pozo, Norberto C, Grubissich, Nicolas, Plotnikow, Gustavo A, Vasquez, Daniela N, Ilutovich, Santiago, Tiribelli, Norberto, Chena, Ariel, Pellegrini, Carlos A, Saenz, María G, Estenssoro, Elisa, Brizuela, Matias, Gianinetto, Hernan, Gomez, Pablo E, Cerrato, Valeria I, Bezzi, Marco G, Borello, Silvina A, Loiacono, Flavia A, Fernandez, Adriana M, Knowles, Serena, Reynolds, Claire, Inskip, Deborah M, Miller, Jennene J, Kong, Jing, Whitehead, Christina, Bihari, Shailesh, Seven, Aylin, Krstevski, Amanda, Rodgers, Helen J, Millar, Rebecca T, Mckenna, Toni E, Bailey, Irene M, Hanlon, Gabrielle C, Aneman, Anders, Lynch, Joan M, Azad, Raman, Neal, John, Woods, Paul W, Roberts, Brigit L, Kol, Mark R, Wong, Helen S, Riss, Katharina C, Staudinger, Thomas, Wittebole, Xavier, Berghe, Caroline, Bulpa, Pierre A, Dive, Alain M, Verstraete, Rik, Lebbinck, Herve, Depuydt, Pieter, Vermassen, Joris, Meersseman, Philippe, Ceunen, Helga, Rosa, Jonas I, Beraldo, Daniel O, Ampinelli, Adenilton M R, Nassar Jr, Antonio P, Mataloun, Sergio, Moock, Marcelo, Thompson, Marlus M, Gonçalves, Claudio H, Antônio, Ana Carolina P, Ascoli, Aline, Biondi, Rodrigo S, Fontenele, Danielle C, Nobrega, Danielle, Sales, Vanessa M, Shindhe, Suresh, Ismail, Dk Maizatul Aiman B Pg Hj, Laffey, John, Beloncle, Francois, Davies, Kyle G, Cirone, Rob, Manoharan, Venika, Ismail, Mehvish, Goligher, Ewan C, Jassal, Mandeep, Nishikawa, Erin, Javeed, Areej, Curley, Gerard, Rittayamai, Nuttapol, Parotto, Matteo, Ferguson, Niall D, Mehta, Sangeeta, Knoll, Jenny, Pronovost, Antoine, Canestrini, Sergio, Bruhn, Alejandro R, Garcia, Patricio H, Aliaga, Felipe A, Farías, Pamela A, Yumha, Jacob S, Ortiz, Claudia A, Salas, Javier E, Saez, Alejandro A, Vega, Luis D, Labarca, Eduardo F, Martinez, Felipe T, Carreño, Nicolás G, Lora, Pilar, Liu, Haitao, Liu, Ling, Tang, Rui, Luo, Xiaoming, An, Youzhong, Zhao, Huiying, Gao, Yan, Zhai, Zhe, Ye, Zheng L, Wang, Wei, Li, Wenwen, Li, Qingdong, Zheng, Ruiqiang, Yu, Wenkui, Shen, Juanhong, Li, Xinyu, Yu, Tao, Lu, Weihua, Wu, Ya Q, Huang, Xiao B, He, Zhenyang, Lu, Yuanhua, Han, Hui, Zhang, Fan, Sun, Renhua, Wang, Hua X, Qin, Shu H, Zhu, Bao H, Zhao, Jun, Liu, Jian, Li, Bin, Liu, Jing L, Zhou, Fa C, Li, Qiong J, Zhang, Xing Y, Li-Xin, Zhou, Xin-Hua, Qiang, Jiang, Liangyan, Gao, Yuan N, Zhao, Xian Y, Li, Yuan Y, Li, Xiao L, Wang, Chunting, Yao, Qingchun, Yu, Rongguo, Chen, Kai, Shao, Huanzhang, Qin, Bingyu, Huang, Qing Q, Zhu, Wei H, Hang, Ai Y, Hua, Ma X, Li, Yimin, Xu, Yonghao, Di, Yu D, Ling, Long L, Qin, Tie H, Wang, Shou H, Qin, Junping, Han, Yi, Zhou, Suming, Vargas, Monica P, Silesky Jimenez, Juan I, González Rojas, Manuel A, Solis-Quesada, Jaime E, Ramirez-Alfaro, Christian M, Máca, Jan, Sklienka, Peter, Gjedsted, Jakob, Christiansen, Aage, Villamagua, Boris G, Llano, Miguel, Burtin, Philippe, Buzancais, Gautier, Beuret, Pascal, Pelletier, Nicolas, Mortaza, Satar, Mercat, Alain, Chelly, Jonathan, Jochmans, Sébastien, Terzi, Nicolas, Daubin, Cédric, Carteaux, Guillaume, de Prost, Nicolas, Chiche, Jean-Daniel, Daviaud, Fabrice, Pham, Tai, Fartoukh, Muriel, Barberet, Guillaume, Biehler, Jerome, Dellamonica, Jean, Doyen, Denis, Arnal, Jean-Michel, Briquet, Anais, Hraiech, Sami, Papazian, Laurent, Follin, Arnaud, Roux, Damien, Messika, Jonathan, Kalaitzis, Evangelos, Dangers, Laurence, Combes, Alain, Au, Siu-Ming, Béduneau, Gaetan, Carpentier, Dorothée, Zogheib, Elie H, Dupont, Herve, Ricome, Sylvie, Santoli, Francesco L, Besset, Sebastien L, Michel, Philippe, Gelée, Bruno, Danin, Pierre-Eric, Goubaux, Bernard, Crova, Philippe J, Phan, Nga T, Berkelmans, Frantz, Badie, Julio C, Tapponnier, Romain, Gally, Josette, Khebbeb, Samy, Herbrecht, Jean-Etienne, Schneider, Francis, Declercq, Pierre-Louis M, Rigaud, Jean-Philippe, Duranteau, Jacques, Harrois, Anatole, Chabanne, Russell, Marin, Julien, Bigot, Charlene, Thibault, Sandrine, Ghazi, Mohammed, Boukhazna, Messabi, Ould Zein, Salem, Richecoeur, Jack R, Combaux, Daniele M, Grelon, Fabien, Le Moal, Charlene, Sauvadet, Elise P, Robine, Adrien, Lemiale, Virginie, Reuter, Danielle, Dres, Martin, Demoule, Alexandre, Goldgran-Toledano, Dany, Baboi, Loredana, Guérin, Claude, Lohner, Ralph, Kraßler, Jens, Schäfer, Susanne, Zacharowski, Kai D, Meybohm, Patrick, Reske, Andreas W, Simon, Philipp, Hopf, Hans-Bernd F, Schuetz, Michael, Baltus, Thomas, Papanikolaou, Metaxia N, Papavasilopoulou, Theonymfi G, Zacharas, Giannis A, Ourailogloy, Vasilis, Mouloudi, Eleni K, Massa, Eleni V, Nagy, Eva O, Stamou, Electra E, Kiourtzieva, Ellada V, Oikonomou, Marina A, Avila, Luis E, Cortez, Cesar A, Citalán, Johanna E, Jog, Sameer A, Sable, Safal D, Shah, Bhagyesh, Gurjar, Mohan, Baronia, Arvind K, Memon, Mohammedfaruk, Muthuchellappan, Radhakrishnan, Ramesh, Venkatapura J, Shenoy, Anitha, Unnikrishnan, Ramesh, Dixit, Subhal B, Rhayakar, Rachana V, Ramakrishnan, Nagarajan, Bhardwaj, Vallish K, Mahto, Heera L, Sagar, Sudha V, Palaniswamy, Vijayanand, Ganesan, Deeban, Mohammadreza Hashemian, Seyed, Jamaati, Hamidreza, Heidari, Farshad, Meaney, Edel A, Nichol, Alistair, Knapman, Karl M, O'Croinin, Donall, Dunne, Eimhin S, Breen, Dorothy M, Clarkson, Kevin P, Jaafar, Rola F, Dwyer, Rory, Amir, Fahd, Ajetunmobi, Olaitan O, O'Muircheartaigh, Aogan C, Black, Colin S, Treanor, Nuala, Collins, Daniel V, Altaf, Wahid, Zani, Gianluca, Fusari, Maurizio, Spadaro, Savino, Volta, Carlo A, Graziani, Romano, Brunettini, Barbara, Palmese, Salvatore, Formenti, Paolo, Umbrello, Michele, Lombardo, Andrea, Pecci, Elisabetta, Botteri, Marco, Savioli, Monica, Protti, Alessandro, Mattei, Alessia, Schiavoni, Lorenzo, Tinnirello, Andrea, Todeschini, Manuel, Giarratano, Antonino, Cortegiani, Andrea, Sher, Sara, Rossi, Anna, Antonelli, Massimo M, Montini, Luca M, Casalena, Paolo, Scafetti, Sergio, Panarello, Giovanna, Occhipinti, Giovanna, Patroniti, Nicolò, Pozzi, Matteo, Biscione, Roberto R, Poli, Michela M, Raimondi, Ferdinando, Albiero, Daniela, Crapelli, Giulia, Beck, Eduardo, Pota, Vincenzo, Schiavone, Vincenzo, Molin, Alexandre, Tarantino, Fabio, Monti, Giacomo, Frati, Elena, Mirabella, Lucia, Cinnella, Gilda, Fossali, Tommaso, Colombo, Riccardo, Terragni, Pierpaolo, Pattarino, Ilaria, Mojoli, Francesco, Braschi, Antonio, Borotto, Erika E, Cracchiolo, Andrea N, Palma, Daniela M, Raponi, Francesco, Foti, Giuseppe, Vascotto, Ettore R, Coppadoro, Andrea, Brazzi, Luca, Floris, Leda, Iotti, Giorgio A, Venti, Aaron, Yamaguchi, Osamu, Takagi, Shunsuke, Maeyama, Hiroki N, Watanabe, Eizo, Yamaji, Yoshihiro, Shimizu, Kazuyoshi, Shiozaki, Kyoko, Futami, Satoru, Ryosuke, Sekine, Saito, Koji, Kameyama, Yoshinobu, Ueno, Keiko, Izawa, Masayo, Okuda, Nao, Suzuki, Hiroyuki, Harasawa, Tomofumi, Nasu, Michitaka, Takada, Tadaaki, Ito, Fumihito, Nunomiya, Shin, Koyama, Kansuke, Abe, Toshikazu, Andoh, Kohkichi, Kusumoto, Kohei, Hirata, Akira, Takaba, Akihiro, Kimura, Hiroyasu, Matsumoto, Shuhei, Higashijima, Ushio, Honda, Hiroyuki, Aoki, Nobumasa, Imai, Hiroshi, Ogino, Yasuaki, Mizuguchi, Ichiko, Ichikado, Kazuya, Nitta, Kenichi, Mochizuki, Katsunori, Hashida, Tomoaki, Tanaka, Hiroyuki, Nakamura, Tomoyuki, Niimi, Daisuke, Ueda, Takeshi, Kashiwa, Yozo, Uchiyama, Akinori, Sabelnikovs, Olegs, Oss, Peteris, Haddad, Youssef, Liew, Kong Y, Ñamendys-Silva, Silvio A, Jarquin-Badiola, Yves D, Sanchez-Hurtado, Luis A, Gomez-Flores, Saira S, Marin, Maria C, Villagomez, Asisclo J, Lemus, Jordana S, Fierro, Jonathan M, Cervantes, Mavy Ramirez, Mejia, Francisco Javier Flores, Gonzalez, Daniel R, Dector, Dulce M, Estrella, Claudia R, Sanchez-Medina, Jorge R, Ramirez-Gutierrez, Alvaro, George, Fernando G, Aguirre, Janet S, Buensuseso, Juan A, Poblano, Manuel, Dendane, Tarek, Balkhi, Hicham, Elkhayari, Mina, Samkaoui, Nacer, Ezzouine, Hanane, Benslama, Abdellatif, Amor, Mourad, Maazouzi, Wajdi, Cimic, Nedim, Beck, Oliver, Bruns, Monique M, Schouten, Jeroen A, Rinia, Myra, Raaijmakers, Monique, Van Wezel, Hellen M, Heines, Serge J, Buise, Marc P, Simonis, Fabienne D, Schultz, Marcus J, Goodson, Jennifer C, rowne, Troy S B, Navarra, Leanlove, Hunt, Anna, Hutchison, Robyn A, Bailey, Mathew B, Newby, Lynette, Mcarthur, Colin, Kalkoff, Michael, Mcleod, Alex, Casement, Jonathan, Hacking, Danielle J, Andersen, Finn H, Dolva, Merete S, Laake, Jon H, Barratt-Due, Andreas, Noremark, Kim Andre L, Søreide, Eldar, Sjøbø, Brit Å, Guttormsen, Anne B, Yoshido, Hector H Leon, Aguilar, Ronald Zumaran, Oscanoa, Fredy A Montes, Alisasis, Alain U, Robles, Joanne B, Pasanting-Lim, Rossini Abbie B, Tan, Beatriz C, Andruszkiewicz, Pawel, Jakubowska, Karina, Cox, Cristina M, Alvarez, António M, Oliveira, Bruno S, Montanha, Gustavo M, Barros, Nelson C, Pereira, Carlos S, Messias, António M, Monteiro, Jorge M, Araujo, Ana M, Catorze, Nuno T, Marum, Susan M, Bouw, Maria J, Gomes, Rui M, Brito, Vania A, Castro, Silvia, Estilita, Joana M, Barros, Filipa M, Serra, Isabel M, Martinho, Aurelia M, Tomescu, Dana R, Marcu, Alexandra, Bedreag, Ovidiu H, Papurica, Marius, Corneci, Dan E, Negoita, Silvius Ioan, Grigoriev, Evgeny, Gritsan, Alexey I, Gazenkampf, Andrey A, Almekhlafi, Ghaleb, Albarrak, Mohamad M, Mustafa, Ghanem M, Maghrabi, Khalid A, Salahuddin, Nawal, Aisa, Tharwat M, Al Jabbary, Ahmed S, Tabhan, Edgardo, Arabi, Yaseen M, Trinidad, Olivia A, Al Dorzi, Hasan M, Tabhan, Edgardo E, Bolon, Stefan, Smith, Oliver, Mancebo, Jordi, Aguirre-Bermeo, Hernan, Lopez-Delgado, Juan C, Esteve, Francisco, Rialp, Gemma, Forteza, Catalina, De Haro, Candelaria, Artigas, Antonio, Albaiceta, Guillermo M, De Cima-Iglesias, Sara, Seoane-Quiroga, Leticia, Ceniceros-Barros, Alexandra, Ruiz-Aguilar, Antonio L, Claraco-Vega, Luis M, Soler, Juan Alfonso, Lorente, Maria del Carmen, Hermosa, Cecilia, Gordo, Federico, Prieto-González, Miryam, López-Messa, Juan B, Perez, Manuel P, Pere, Cesar P, Allue, Raquel Montoiro, Roche-Campo, Ferran, Ibañez-Santacruz, Marcos, Temprano, Susana, Pintado, Maria C, De Pablo, Raul, Gómez, Pilar Ricart Aroa, Ruiz, Silvia Rodriguez, Moles, Silvia Iglesias, Jurado, Mª Teresa, Arizmendi, Alfons, Piacentini, Enrique A, Franco, Nieves, Honrubia, Teresa, Perez Cheng, Meisy, Perez Losada, Elena, Blanco, Javier, Yuste, Luis J, Carbayo-Gorriz, Cecilia, Cazorla-Barranquero, Francisca G, Alonso, Javier G, Alda, Rosa S, Algaba, Ángela, Navarro, Gonzalo, Cereijo, Enrique, Diaz-Rodriguez, Esther, Marcos, Diego Pastor, Montero, Laura Alvarez, Para, Luis Herrera, Sanchez, Roberto Jimenez, Blasco Navalpotro, Miguel Angel, Abad, Ricardo Diaz, Montiel González, Raquel, Toribio, Dácil Parrilla, Castro, Alejandro G, Artiga, Maria Jose D, Penuelas, Oscar, Roser, Tomas P, Olga, Moreno F, Curto, Elena Gallego, Sánchez, Rocío Manzano, Imma, Vallverdu P, Elisabet, Garcia M, Claverias, Laura, Magret, Monica, Pellicer, Ana M, Rodriguez, Lucia L, Sánchez-Ballesteros, Jesús, González-Salamanca, Ángela, Jimenez, Antonio G, Huerta, Francisco P, Diaz, Juan Carlos J Sotillo, Lopez, Esther Bermejo, Moya, David D Llinares, Alfonso, Alec A Tallet, Eugenio Luis, Palazon Sanchez, Cesar, Palazon Sanchez, Rafael, Sánchez I, Virgilio, Corcoles G, Recio, Noelia N, Adamsson, Richard O, Rylander, Christian C, Holzgraefe, Bernhard, Broman, Lars M, Wessbergh, Joanna, Persson, Linnea, Schiöler, Fredrik, Kedelv, Hans, Tibblin, Anna Oscarsson, Appelberg, Henrik, Hedlund, Lars, Helleberg, Johan, Eriksson, Karin E, Glietsch, Rita, Larsson, Niklas, Nygren, Ingela, Nunes, Silvia L, Morin, Anna-Karin, Kander, Thomas, Adolfsson, Anne, Zender, Hervé O, Leemann-Refondini, Corinne, Elatrous, Souheil, Bouchoucha, Slaheddine, Chouchene, Imed, Ouanes, Islem, Ben Souissi, Asma, Kamoun, Salma, Demirkiran, Oktay, Aker, Mustafa, Erbabacan, Emre, Ceylan, Ilkay, Girgin, Nermin Kelebek, Ozcelik, Menekse, Ünal, Necmettin, Meco, Basak Ceyda, Akyol, Onat O, Derman, Suleyman S, Kennedy, Barry, Parhar, Ken, Srinivasa, Latha, McAuley, Danny, Steinberg, Jack, Hopkins, Phil, Mellis, Clare, Stansil, Frank, Kakar, Vivek, Hadfield, Dan, Brown, Christine, Vercueil, Andre, Bhowmick, Kaushik, Humphreys, Sally K, Ferguson, Andrew, Mckee, Raymond, Raj, Ashok S, Fawkes, Danielle A, Watt, Philip, Twohey, Linda, Thomas, Rajeev R Jha Matthew, Morton, Alex, Kadaba, Varsha, Smith, Mark J, Hormis, Anil P, Kannan, Santhana G, Namih, Miriam, Reschreiter, Henrik, Camsooksai, Julie, Kumar, Alek, Rugonfalvi, Szabolcs, Nutt, Christopher, Oneill, Orla, Seasman, Colette, Dempsey, Ged, Scott, Christopher J, Ellis, Helen E, Mckechnie, Stuart, Hutton, Paula J, Di Tomasso, Nora N, Vitale, Michela N, Griffin, Ruth O, Dean, Michael N, Cranshaw, Julius H, Willett, Emma L, Ioannou, Nicholas, Gillis, Sarah, Csabi, Peter, Macfadyen, Rosaleen, Dawson, Heidi, Preez, Pieter D, Williams, Alexandra J, Boyd, Owen, De Gordoa, Laura Ortiz-Ruiz, Bramall, Jon, Symmonds, Sophie, Chau, Simon K, Wenham, Tim, Szakmany, Tamas, Toth-Tarsoly, Piroska, Mccalman, Katie H, Alexander, Peter, Stephenson, Lorraine, Collyer, Thomas, Chapman, Rhiannon, Cooper, Raphael, Allan, Russell M, Sim, Malcolm, Wrathall, David W, Irvine, Donald A, Zantua, Kim S, Adams, John C, Burtenshaw, Andrew J, Sellors, Gareth P, Welters, Ingeborg D, Williams, Karen E, Hessell, Robert J, Oldroyd, Matthew G, Battle, Ceri E, Pillai, Suresh, Kajtor, Istvan, Sivashanmugave, Mageswaran, Okane, Sinead C, Donnelly, Adrian, Frigyik, Aniko D, Careless, Jon P, May, Martin M, Stewart, Richard, Trinder, T John, Hagan, Samantha J, Wise, Matt P, Cole, Jade M, MacFie, Caroline C, Dowling, Anna T, Nin, Nicolás, Nuñez, Edgardo, Pittini, Gustavo, Rodriguez, Ruben, Imperio, María C, Santos, Cristina, França, Ana G, Ebeid, Alejandro, Deicas, Alberto, Serra, Carolina, Uppalapati, Aditya, Kamel, Ghassan, Banner-Goodspeed, Valerie M, Beitler, Jeremy R, Mukkera, Satyanarayana Reddy, Kulkarni, Shreedhar, Lee, Jarone, Mesar, Tomaz, Shinn Iii, John O, Gomaa, Dina, Tainter, Christopher, Cowley, R Adams, Yeatts, Dale J, Warren, Jessica, Lanspa, Michael J, Miller, Russel R, Grissom, Colin K, Brown, Samuel M, Bauer, Philippe R, Gosselin, Ryan J, Kitch, Barrett T, Cohen, Jason E, Beegle, Scott H, Gueret, Renaud M, Tulaimat, Aiman, Choudry, Shazia, Stigler, William, Batra, Hitesh, Huff, Nidhi G, Lamb, Keith D, Oetting, Trevor W, Mohr, Nicholas M, Judy, Claine, Saito, Shigeki, Kheir, Fayez M, Schlichting, Adam B, Delsing, Angela, Elmasri, Mary, Crouch, Daniel R, Ismail, Dina, Blakeman, Thomas C, Dreyer, Kyle R, Baron, Rebecca M, Grijalba, Carolina Quintana, Hou, Peter C, Seethala, Raghu, Aisiku, Imo, Henderson, Galen, Frendl, Gyorgy, Hou, Sen-Kuang, Owens, Robert L, Schomer, Ashley, Bumbasirevic, Vesna, Jovanovic, Bojan, Surbatovic, Maja, Veljovic, Milic, Rodgers, Helen, Dixon, Barry, Smith, Roger, Kol, Mark, Wong, Helen, Schmid, Werner, Hermans, Greet, Bourgeois, Marc, Anquez, Nathalie, Decruyenaere, Johan, DeCrop, Luc, Neto, Ary Serpa, Souza dos Santos, Rafaella, Beraldo, Daniel, dos Santos, Moreno Calcagnotto, Pellegrini, Jose Augusto Santos, Oliveira, Vanessa, Munhoz, Carlos, Peçanha, Ana Carolina, da Silva Ramos, Fernando José, Maia, Israel, Bahl, Marina, Biondi, Rodrigo, Prado, Daniel, Pinto, Sérgio Felix, Salgado, Jean, Falcão, Luis Fernando, Macruz, Tiago, Ruas, Kessia, Mecatti, Giovana Colozza, Caser, Eliane Bernadete, Gava, Isabela Ambrósio, Carreño, Nicolás, Morales, Mauricio, Avendaño, Rossana, Aguirre, Stefania, Sribar, Andrej, Klaric, Vlasta, Skilijic, Sonja, Dvorscak, Matea Bogdanovic, Krkusek, Marijana, Jurjevic, Matija, Karanovic, Nenad, Simurina, Tatjana, Stourac, Petr, Kratochvil, Milan, Schlegel, Christian, Treschan, Tanja A, Schaefer, Maximilian, Aytulun, Akut, Kienbaum, Peter, Jaafar, Rola, Collins, Daniel, Plant, Robert, Melchionda, Giuseppe, Di Lauro, Eduardo, Russotto, Vincenzo, Caione, Raffaele, Mestria, Donatella, Volta, Carlo Alberto, Seghelini, Elisa, Sales, Gabriele, D'Antini, Davide, Severgnini, Paolo, Bacuzzi, Alessandro, Peluso, Lorenzo, Verrastro, Pasquale, Raimondo, Pasquale, Gecaj-Gashi, Agreta, Tuinman, Pieter Roel, Alberts, Erna, van den Hul, Ingrid, Kuiper, Michael, de Wilde, Robert BP, Koopmans, Matty, Kose, Isil, Zincircioglu, Çiler, Dogan, Nazim, Aydin, Demet, Denker, Ahmet Sukru, Buyukkocak, Unase, Akgun, Nur, Turan, Güldem, Senturk, Evren, Demirtürk, Zerrin, Özcan, Perihan Ergin, Ekinci, Osman, Saylan, Sedat, Eren, Gulay, Ulger, Fatma, Dilek, Ahmet, Ulusoy, Hulya, Goktas, Ugur, Soyoral, Lokman, Toman, Huseyin, Orak, Yavuz, Kahveci, Feda, Mills, Gary H, Pinder, Angela, Walker, Rachel, Harrison, Jonathan, Snell, Jane, Pearson, Rachel, Sharman, Michael, Kaloo, Claire, Bynorth, Natalie, Matthews, Kelly, Hughes, Chloe, Rose, Alastair, Simeson, Karen, Niska, Lotta, Huneke, Nathan, Adderly, Jane, Padilla-Harris, Cheryl, Oliver, Rebecca, Brohi, Farooq, Wilson, Natalie, Talbot, Helen, Wilson, Deborah, Smith, Deborah, Dark, Paulo, Evans, Tracey, Fisher, Nicola, Montgomery, Jane, Fitzell, Pauline, Muench, Christoph, Hugill, Keith, Cirstea, Emanuel, Bentley, Andrew, Lynch, Katie, White, Ian, Cooper, Jonathan, Brazier, Melinda, Devile, Michael, Parris, Michael, Gill, Pardeep, Patel, Tasmin, Criswell, John, Trodd, Dawn, Griffin, Denise, Martin, Jane, Wreybrown, Caroline, Bewley, Jeremy, Sweet, Katie, Grimmer, Lisa, Kozlowski, Marta, James, Shanaz, Limb, James, Cowton, Amanda, Rogerson, David, Downes, Charlotte, Melbourne, Susan, Humphries, Ryan, Pulletz, Mark, Moreton, Sarah, Janes, Stephanie, Corner, Andrew, Linnett, Vanessa, Ritzema, Jenny, Watters, Malcolm, Windebank, Steve, Chenna, Shailaja, Howard-Griffin, Richard, Turner, Kate, Suresh, Sheeba, Blaylock, Heather, Bell, Stephanie, Blenk, Karl, Everett, Lynn, Hadfield, Daniel, Harris, Clair, Chan, Alexandre, Birch, Sian, Pegg, Claire, Plowright, Catherine, Cooper, Lucy, Hatton, Tom, McCullagh, Iain, Wright, Stephen, Scott, Carmen, Boyd, Christine, Holliday, Mark, Poultney, Una, Crowther, Hannah, Thornthwaite, Sarah, Hollister, Nigel, Hunt, Jane, Skinner, Amanda, Matsa, Ramprasad, Salt, Ruth, Matthews, Claire, Venner, Nicola, Barcraft-Barnes, Helena, Tbaily, Lee, Pogson, David, Mouland, Johanna, Rose, Steve, Lamb, Nicola, Tarmey, Nicholas, Knighton, John, Giles, Julian, Weller, Debbie, Reed, Isabelle, Hormis, Anil, Pearson, Sallyane, Harris, Meredith, Howe, Joanne, Paddle, Jonathan, Burt, Karen, Welters, Ingeborg, Walker, Anna, Youds, Laura, Hendry, Sam, Shaw, David, Williams, Karen, Hollands, Robin, Carnahan, Mandy, Stickley, Johanna, Miller, Claire, Donaldson, Denise, Tonks, Louise, Creagh-Brown, Ben, Hull, Daniel, Ortiz-Ruiz, Laura, Gopal, Shammer, Metherell, Stella, Spencer, Hazel, Frey, Christian, Brown, Carly, Clifford, Gayle, Leaver, Susannah, Ryan, Christine, Mellinghoff, Johannes Mellinghoff, Prudden, Sarah Prudden, Green, Helen Green, Roy, Alistair Roy, Furneval, Julie Furneval, Bell, Adam Bell, Lakhani, Sandeep Lakhani, Fasting, Lousie Fasting, Murray, Lorna Murray, Preller, Kobus, McInerney, Amy, Beavis, Sarah, Whileman, Amanda, Toms, Julie, Glenn, Sue, Ramali, Mohamed, Ghosh, Alison, Bullock, Clare, Barrell, Lisa, Young, Eoin, Robertson, Helen, Faulkner, Maria, MacNaughton, Peter, Tyson, Susan, Pulak, Paul, Sewell, Terri-Ann, Smalley, Christopher, Jacob, Reni, Alzugaray, Pedro, Vidal Melo, Marcos F, Joyce, Kristen, Needleman, Joseph, Ahsan, Areef, Faiz, Abul, Alam, AKM Shamsul, Khatoon, Syeda Nafisa, Nath, Ranjan Kumer, Rahman Chowdhury, Mohammed Abdur, Banik, Debabrata, Mondol, Montosh Kumar, Bhuiyan, Sakibur Rahman, Nazneed, Suraiya, Sultana, Rozina, Hamid, Tarikul, Hossain, Mozaffer, Reza, Syed Tariq, Asaduzzaman, Muhammad, Salim, Mohammad, Mostafa Kamal, Abu Hena, Taher, Sheikh Mohammed, Taohid, Taohidul Majid, Karmaker, Pranab, Roy, Sabyasachi, Das, Shantanu, Sarkar, Sohel Ahmed, Dutta, Monju Lal, Roy, Poulomi, Iyer, Shivakumar, Krishna, Bhuvana, Sampath, Sriram, Pattnaik, Rajyabardhan, Kasi, Chinni Krishna, Shah, Jignesh, Dongre, Anand, Reza Hashemian, Seyed Mohammad, Nooraei, Navid, Raessi Estabragh, Reza, Malekmohammad, Majid, Khoundabi, Batoul, Mobasher, Maziar, Mohd Yunos, Nor'azim, Kassim, Mahazir, Voon, Chern Min, Das, Stanis Sutharsa, Azauddin, Siti Nur Suhaila, Dorasamy, Dharshinie, Tai, Li Ling, Mat Nor, Mohd Basri, Zarudin, Nurhafizah, Hasan, Mohd Shahnaz, Jamaluddin, Mohamad Fadhil Hadi, Othman Jailani, Mohamad Irfan, Kayashta, Gyan, Adhikari, Aaradhana, Pangeni, Raju, Hashmi, Madiha, Joseph, Sonia, Akhtar, Aftab, Qadeer, Aayesha, Memon, Iqbal, Ali, Syed Muneeb, Idrees, Farah, Kamal, Saima, Hanif, Sadaf, Rehman, Atta Ur, Taqi, Arshad, Hussain, Tanveer, Farooq, Ahmed, Khaskheli, Saleh, Hayat, Muhammad, Indraratna, Kanishka, Beane, Abigail, Haniffa, Rashan, Samaranayake, Upeka, Mathanalagan, Sathiyamoorthy, Gunaratne, Asoka, Mithraratne, Nimangee, Thilakasiri, Kaushila, Pilimatalawwe, Chamila, Dilhani, Y A Hasitha, Fernando, Marie, Ranatunge, Kumudini, Samarasinghe, Loranthi, Vaas, Manori, Edirisooriya, Manoj, Sigera, Chathurani, Arumoli, Janaki, De Silva, Kesharie, Kudavidanage, Bimal, Pinto, Visanthi, Dissanayake, Lakshman, Chittawatanarat, Kaweesak, Kongpolprom, Napplika, Silachamroon, Udomsak, Pornsuriyasak, Prapaporn, Petnak, Tananchai, Singhatas, Pongsasit, Tangsujaritvijit, Viratch, Rungruanghiranya, Suthat, Piriyapatsom, Annop, Juntaping, Kanokkarn, Trongtrakul, Konlawij, Thungtitigul, Poungrat, Tajarernmuang, Pattraporn, Chatmongkolchart, Sunisa, Bhurayanontachai, Rungsun, Akaraborworn, Osaree, Navasakulpong, Asma, Surasit, Karjbundid, Thwaites, Louise, Nadjm, Behzad, Vu Quoc, Dat, Nguyen Thi Thanh, Ha, Nguyen Van, Kinh, Duong Bich, Thuy, Lam Minh, Yen, Pisani, Luigi, Algera, Anna Geke, Azevedo, Luciano, Paulus, Frederique, de Abreu, Marcelo Gama, Pelosi, Paolo, Dondorp, Arjen M, and Laffey, John G

Published
2022
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6. Quantum Information Metric and Berry Curvature from a Lagrangian Approach

Author

Alvarez-Jimenez, Javier, Dector, Aldo, and Vergara, J. David

Subjects
High Energy Physics - Theory, Condensed Matter - Statistical Mechanics, Quantum Physics
Abstract

We take as a starting point an expression for the quantum geometric tensor recently derived in the context of the gauge/gravity duality. We proceed to generalize this formalism in such way it is possible to compute the geometrical phases of quantum systems. Our scheme provides a conceptually complete description and introduce a different point of view of earlier works. Using our formalism, we show how this expression can be applied to well-known quantum mechanical systems., Comment: 33 pages, references added and minor comments

Published
2017
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7. Magnetic Phenomena in Holographic Superconductivity with Lifshitz Scaling

Author

Dector, Aldo

Subjects
High Energy Physics - Theory
Abstract

We investigate the effects of Lifshitz dynamical critical exponent z on a family of minimal D=4+1 holographic superconducting models, with a particular focus on magnetic phenomena. We see that it is possible to have a consistent Ginzburg-Landau approach to holographic superconductivity in a Lifshitz background. By following this phenomenological approach we are able to compute a wide array of physical quantities. We also calculate the Ginzburg-Landau parameter for different condensates, and conclude that in systems with higher dynamical critical exponent, vortex formation is more strongly unfavored energetically and exhibit a stronger Type I behavior. Finally, following the perturbative approach proposed by Maeda, Natsuume and Okamura, we calculate the critical magnetic field of our models for different values of z., Comment: 32 pages

Published
2015
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8. Have there been changes in the application of mechanical ventilation in relation to scientific evidence? A multicenter observational study in Mexico

Author

Aguilera Almazán, F., Benítez Cortázar, M., Carrillo Speare, R., Castaño, R., Corral, R., D’Ector Lira, D.N., Díaz Polanco, G., Elizalde, J.J., Envila Fisher, R., Franco, G., García Balbuena, P., Gayoso Cruz, O., Green, L., Herrera Hoyos, J.O., Hinojosa, J., Huerta, J., Juárez, V.A., Loera, M., López Alzate, C., López Mora, E., Martínez Caro, S., Méndez Reyes, R., Mendoza, M., Narváez Porras, O., Ortiz, E., Padua, A., Poblano, M., Pureco Reyes, V., Querevalum, W., Quesada, A., Ramírez Rivera, A., Tamariz, A., Vargas, A., Vázquez, C., Cerda, P., Mercado, R., Albe Castañón, J., Villagómez Ortiz, A.J., Cruz Lozano, C., Maycotte Luna, Z., López Bacal, F., Cueto Robledo, G., Treviño Salinas, M.A., Martínez Zubieta, R., Olvera-Guzmán, C., Montes de Oca, Marco, Ñamendys-Silva, S.A., Martínez Cano, J.S., Baltazar Torres, J.A., Morales Muñoz, G., Villa Delgado, A., Ladape Martínez, J., Ortega Pérez, A., Chávez Morales, A., García Luna, A., Rugiero Cabrera, A., Rugerio Cabrera, A., Pérez-Calatayud, Á.A., Arellano, A., Velasco Gutiérrez, A., Longino Gómez, A.J., Tamariz Becerra Álvarez Calderón, Antonio, Álvarez Calderón Christus Mugerza, R., Reynoso Estrella, C.I., Déctor-Lira Espindola-Cruz, D., Gutiérrez-Zárate, D., Esmeralda, D., Anica Malagón, E.D., Monares Zepeda, E., Deloya, E., Manzo Palacios, E., de Jesús Montelongo, F., Flores Mejía, F.J., Ramírez Cervantes, M., Camarena Alejo, G., Vázquez de Anda, G., Vázquez, H., Larios Luna, C., Zamora, S.E., Magaña Solano, G., Sánchez González, J.I., Rosendo Sánchez Medina, J., Zaragoza, J.J., Buensuseso Alfaro, J.A., Dávila Fernández, J.C., Mijangos-Méndez, J.C., Martínez Medina, M., Chacón Gómez, M., Calyeca Sánchez, M.V., Martínez Soria, J.J., García Graullera, R.J., Rosas, R., Sanjuana Gómez Flores, S., Reyes Inurrigarro, S., Ñamendy-Silva, S.A., Sánchez Hurtado, L.A., Villegas Castellanos, L.L., Zalatiel Maycotte, L., Estrada Gutiérrez, A., León, M.A., Marín, M.C., Elizalde, J., Villagómez, A., Cerón, U., Palma-Lara, I., Sánchez, J.R., Monares, E., Muriel, A., Peñuelas, Ó., Frutos-Vivar, F., and Esteban, A.

Published
2020
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10. Ginzburg-Landau Approach to Holographic Superconductivity

Author

Dector, Aldo

Subjects
High Energy Physics - Theory
Abstract

We construct a family of minimal phenomenological models for holographic superconductors in d=4+1 AdS spacetime and study the effect of scalar and gauge field fluctuations. By making a Ginzburg-Landau interpretation of the dual field theory, we determine through holographic techniques a phenomenological Ginzburg-Landau Lagrangian and the temperature dependence of physical quantities in the superconducting phase. We obtain insight on the behaviour of the Ginzburg-Landau parameter and whether the systems behaves as a Type I or Type II superconductor. Finally, we apply a constant external magnetic field in a perturbative approach following previous work by D'Hoker and Kraus, and obtain droplet solutions which signal the appearance of the Meissner effect., Comment: 41 pages, 31 figures, calculations added

Published
2013
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13. Superconductors for superstrings on AdS_5 x T^{1,1}

Author

Aprile, Francesco, Borghese, Andrea, Dector, Aldo, Roest, Diederik, and Russo, Jorge G.

Subjects
High Energy Physics - Theory
Abstract

We construct a one-parameter family of five-dimensional N=2 supergravity Lagrangians with an SU(2,1) / U(2) hypermultiplet. For certain values of the parameter, these are argued to describe the dynamics of scalar modes of superstrings on AdS_5 x T^{1,1}, and therefore to be dual to specific chiral primary operators of Klebanov-Witten superconformal field theory. We demonstrate that, below a critical temperature, the thermodynamics is dominated by charged black holes with hair for the scalars that are dual to the operator of lowest conformal dimension 3/2. The system thus enters into a superconducting phase where condenses., Comment: 5 pages, 5 figures

Published
2012
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14. An Alternative Canonical Approach to the Ghost Problem in a Complexified Extension of the Pais-Uhlenbeck Oscillator

Author

Déctor, A., Morales-Técotl, H. A., Urrutia, L. F., and Vergara, J. D.

Subjects
Mathematical Physics, General Relativity and Quantum Cosmology, High Energy Physics - Theory, Quantum Physics
Abstract

Our purpose in this paper is to analyze the Pais-Uhlenbeck (PU) oscillator using complex canonical transformations. We show that starting from a Lagrangian approach we obtain a transformation that makes the extended PU oscillator, with unequal frequencies, to be equivalent to two standard second order oscillators which have the original number of degrees of freedom. Such extension is provided by adding a total time derivative to the PU Lagrangian together with a complexification of the original variables further subjected to reality conditions in order to maintain the required number of degrees of freedom. The analysis is accomplished at both the classical and quantum levels. Remarkably, at the quantum level the negative norm states are eliminated, as well as the problems of unbounded below energy and non-unitary time evolution. We illustrate the idea of our approach by eliminating the negative norm states in a complex oscillator. Next, we extend the procedure to the Pais-Uhlenbeck oscillator. The corresponding quantum propagators are calculated using Schwinger's quantum action principle. We also discuss the equal frequency case at the classical level.

Published
2009
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15. Coping with the Pais-Uhlenbeck oscillator's ghosts in a canonical approach

Author

Déctor, Aldo, Morales-Técotl, Hugo A., Urrutia, Luis F., and Vergara, J. David

Subjects
Quantum Physics, General Relativity and Quantum Cosmology, High Energy Physics - Theory
Abstract

A {\em complex} canonical transformation is found that takes the fourth order derivative Pais-Uhlenbeck oscillator into two independent harmonic oscillators thus showing that this model has energy bounded from below, unitary time-evolution and no negative norm states, or ghosts. Such transformation yields a positive definite inner product consistent with reality conditions in the Hilbert space. The method is illustrated by eliminating the negative norm states in a complex oscillator. Extensions to other higher order mechanical models and field theory are discussed., Comment: 5 pages

Published
2008

19. Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study

Author

Laffey, John G., Bellani, Giacomo, Pham, Tai, Fan, Eddy, Brochard, Laurent, Pesenti, Antonio, Esteban, Andres, Gattinoni, Luciano, van Haren, Frank, Larsson, Anders, McAuley, Daniel F., Ranieri, Marco, Rubenfeld, Gordon, Thompson, B Taylor, Wrigge, Hermann, Slutsky, Arthur S., Rios, Fernando, Sottiaux, Thierry, Depuydt, Pieter, Lora, Fredy S, Azevedo, Luciano C, Bugedo, Guillermo, Qiu, Haibo, Gonzalez, Marcos, Silesky, Juan, Cerny, Vladimir, Nielsen, Jonas, Jibaja, Manuel, Matamis, Dimitrios, Ranero, Jorge L., Amin, Pravin, Hashemian, S.M., Clarkson, Kevin, Kurahashi, Kiyoyasu, Villagomez, Asisclo, Zeggwagh, Amine Ali, Heunks, Leo M, Laake, Jon Henrik, Palo, Jose Emmanuel, Fernandes, Antero do Vale, Sandesc, Dorel, Arabi, Yaasen, Bumbasierevic, Vesna, Nin, Nicolas, Lorente, Jose A., Piquilloud, Lise, Abroug, Fekri, McNamee, Lia, Hurtado, Javier, Bajwa, Ed, Démpaire, Gabriel, Sula, Hektor, Nunci, Lordian, Cani, Alma, Zazu, Alan, Dellera, Christian, Alejandro, Risso V, Daldin, Julio, Fernandez, Ruben O, Cardonnet, Luis P, Bettini, Lisandro R., Bisso, Mariano Carboni, Osman, Emilio M., Setten, Mariano G., Lovazzano, Pablo, Alvarez, Javier, Villar, Veronica, Pozo, Norberto C., Grubissich, Nicolas, Plotnikow, Gustavo A., Vasquez, Daniela N., Ilutovich, Santiago, Tiribelli, Norberto, Chena, Ariel, Pellegrini, Carlos A., Saenz, María G., Estenssoro, Elisa, Brizuela, Matias, Gianinetto, Hernan, Gomez, Pablo E., Cerrato, Valeria I., Bezzi, Marco G., Borello, Silvina A., Loiacono, Flavia A., Fernandez, Adriana M., Knowles, Serena, Reynolds, Claire, Inskip, Deborah M., Miller, Jennene J, Kong, Jing, Whitehead, Christina, Bihari, Shailesh, Seven, Aylin, Krstevski, Amanda, Rodgers, Helen, Millar, Rebecca, Mckenna, Toni, Bailey, Irene, Hanlon, Gabrielle, Aneman, Anders, Lynch, Joan, Azad, Raman, Neal, John, Woods, Paul, Roberts, Brigit, Kol, Mark, Wong, Helen, Riss, Katharina, Staudinger, Thomas, Wittebole, Xavier, Berghe, Caroline, Bulpa, Pierre, Dive, Alain, Verstraete, Rik, Lebbinck, Herve, Vermassen, Joris, Meersseman, Philippe, Ceunen, Helga, Rosa, Jonas, Beraldo, Daniel, Piras, Claudio, Rampinelli, Adenilton, Nassar, Antonio, Mataloun, Sergio, Moock, Marcelo, Thompson, Marlus, Gonçalves, Claudio, Antônio, Ana, Ascoli, Aline, Biondi, Rodrigo, Fontenele, Danielle, Nobrega, Danielle, Sales, Vanessa, Shindhe, Suresh, Ismail, Dk, Beloncle, Francois, Davies, Kyle, Cirone, Rob, Manoharan, Venika, Ismail, Mehvish, Goligher, Ewan, Jassal, Mandeep, Nishikawa, Erin, Javeed, Areej, Curley, Gerard, Rittayamai, Nuttapol, Parotto, Matteo, Ferguson, Niall, Mehta, Sangeeta, Knoll, Jenny, Pronovost, Antoine, Canestrini, Sergio, Bruhn, Alejandro, Garcia, Patricio, Aliaga, Felipe, Farías, Pamela, Yumha, Jacob, Ortiz, Claudia, Salas, Javier, Saez, Alejandro, Vega, Luis, Labarca, Eduardo, Martinez, Felipe, Carreño, Nicolás, Lora, Pilar, Liu, Haitao, Liu, Ling, Tang, Rui, Luo, Xiaoming, An, Youzhong, Zhao, Huiying, Gao, Yan, Zhai, Zhe, Ye, Zheng, Wang, Wei, Li, Wenwen, Li, Qingdong, Zheng, Ruiqiang, Yu, Wenkui, Shen, Juanhong, Li, Xinyu, Yu, Tao, Lu, Weihua, Wu, Ya, Huang, Xiao, He, Zhenyang, Lu, Yuanhua, Han, Hui, Zhang, Fan, Sun, Renhua, Wang, Hua, Qin, Shu, Zhu, Bao, Zhao, Jun, Liu, Jian, Li, Bin, Liu, Jing, Zhou, Fa, Li, Qiong, Zhang, Xing, Li-Xin, Zhou, Xin-Hua, Qiang, Jiang, Liangyan, Gao, Yuan, Zhao, Xian, Li, Yuan, Li, Xiao, Wang, Chunting, Yao, Qingchun, Yu, Rongguo, Chen, Kai, Shao, Huanzhang, Qin, Bingyu, Huang, Qing, Zhu, Wei, Hang, Ai, Hua, Ma, Li, Yimin, Xu, Yonghao, Di, Yu, Ling, Long, Qin, Tie, Wang, Shou, Qin, Junping, Han, Yi, Zhou, Suming, Vargas, Monica, Jimenez, Juan, Rojas, Manuel, Solis-Quesada, Jaime, Ramirez-Alfaro, Christian, Máca, Jan, Sklienka, Peter, Gjedsted, Jakob, Christiansen, Aage, Villamagua, Boris, Llano, Miguel, Burtin, Philippe, Buzancais, Gautier, Beuret, Pascal, Pelletier, Nicolas, Mortaza, Satar, Mercat, Alain, Chelly, Jonathan, Jochmans, Sébastien, Terzi, Nicolas, Daubin, Cédric, Carteaux, Guillaume, de Prost, Nicolas, Chiche, Jean-Daniel, Daviaud, Fabrice, Fartoukh, Muriel, Barberet, Guillaume, Biehler, Jerome, Dellamonica, Jean, Doyen, Denis, Arnal, Jean-Michel, Briquet, Anais, Hraiech, Sami, Papazian, Laurent, Roux, Damien, Messika, Jonathan, Kalaitzis, Evangelos, Dangers, Laurence, Combes, Alain, Au, Siu-Ming, Béduneau, Gaetan, Carpentier, Dorothée, Zogheib, Elie, Dupont, Herve, Ricome, Sylvie, Santoli, Francesco, Besset, Sebastien, Michel, Philippe, Gelée, Bruno, Danin, Pierre-Eric, Goubaux, Bernard, Crova, Philippe, Phan, Nga, Berkelmans, Frantz, Badie, Julio, Tapponnier, Romain, Gally, Josette, Khebbeb, Samy, Herbrecht, Jean-Etienne, Schneider, Francis, Declercq, Pierre-Louis, Rigaud, Jean-Philippe, Duranteau, Jacques, Harrois, Anatole, Chabanne, Russell, Marin, Julien, Bigot, Charlene, Thibault, Sandrine, Ghazi, Mohammed, Boukhazna, Messabi, Zein, Salem, Richecoeur, Jack, Combaux, Daniele, Grelon, Fabien, Le Moal, Charlene, Sauvadet, Elise, Robine, Adrien, Lemiale, Virginie, Reuter, Danielle, Dres, Martin, Demoule, Alexandre, Goldgran-Toledano, Dany, Baboi, Loredana, Guérin, Claude, Lohner, Ralph, Kraßler, Jens, Schäfer, Susanne, Zacharowski, Kai, Meybohm, Patrick, Reske, Andreas, Simon, Philipp, Hopf, Hans-Bernd, Schuetz, Michael, Baltus, Thomas, Papanikolaou, Metaxia, Papavasilopoulou, Theonymfi, Zacharas, Giannis, Ourailogloy, Vasilis, Mouloudi, Eleni, Massa, Eleni, Nagy, Eva, Stamou, Electra, Kiourtzieva, Ellada, Oikonomou, Marina, Avila, Luis, Cortez, Cesar, Citalán, Johanna, Jog, Sameer, Sable, Safal, Shah, Bhagyesh, Gurjar, Mohan, Baronia, Arvind, Memon, Mohammedfaruk, Muthuchellappan, Radhakrishnan, Ramesh, Venkatapura, Shenoy, Anitha, Unnikrishnan, Ramesh, Dixit, Subhal, Rhayakar, Rachana, Ramakrishnan, Nagarajan, Bhardwaj, Vallish, Mahto, Heera, Sagar, Sudha, Palaniswamy, Vijayanand, Ganesan, Deeban, Hashemian, Seyed, Jamaati, Hamidreza, Heidari, Farshad, Meaney, Edel, Nichol, Alistair, Knapman, Karl, O'Croinin, Donall, Dunne, Eimhin, Breen, Dorothy, Jaafar, Rola, Dwyer, Rory, Amir, Fahd, Ajetunmobi, Olaitan, O'Muircheartaigh, Aogan, Black, Colin, Treanor, Nuala, Collins, Daniel, Altaf, Wahid, Zani, Gianluca, Fusari, Maurizio, Spadaro, Savino, Volta, Carlo, Graziani, Romano, Brunettini, Barbara, Palmese, Salvatore, Formenti, Paolo, Umbrello, Michele, Lombardo, Andrea, Pecci, Elisabetta, Botteri, Marc, Savioli, Monica, Protti, Alessandro, Mattei, Alessia, Schiavoni, Lorenzo, Tinnirello, Andrea, Todeschini, Manuel, Giarratano, Antonino, Cortegiani, Andrea, Sher, Sara, Rossi, Anna, Antonelli, Massimo, Montini, Luca, Casalena, Paolo, Scafetti, Sergio, Panarello, Giovanna, Occhipinti, Giovanna, Patroniti, Nicolò, Pozzi, Matteo, Biscione, Roberto, Poli, Michela, Raimondi, Ferdinando, Albiero, Daniela, Crapelli, Giulia, Beck, Eduardo, Pota, Vincenzo, Schiavone, Vincenzo, Molin, Alexandre, Tarantino, Fabio, Monti, Giacomo, Frati, Elena, Mirabella, Lucia, Cinnella, Gilda, Fossali, Tommaso, Colombo, Riccardo, Terragni, Pierpaolo, Pattarino, Ilaria, Mojoli, Francesco, Braschi, Antonio, Borotto, Erika, Cracchiolo, Andrea, Palma, Daniela, Raponi, Francesco, Foti, Giuseppe, Vascotto, Ettore, Coppadoro, Andrea, Brazzi, Luca, Floris, Leda, Iotti, Giorgio, Venti, Aaron, Yamaguchi, Osamu, Takagi, Shunsuke, Maeyama, Hiroki, Watanabe, Eizo, Yamaji, Yoshihiro, Shimizu, Kazuyoshi, Shiozaki, Kyoko, Futami, Satoru, Ryosuke, Sekine, Saito, Koji, Kameyama, Yoshinobu, Ueno, Keiko, Izawa, Masayo, Okuda, Nao, Suzuki, Hiroyuki, Harasawa, Tomofumi, Nasu, Michitaka, Takada, Tadaaki, Ito, Fumihito, Nunomiya, Shin, Koyama, Kansuke, Abe, Toshikazu, Andoh, Kohkichi, Kusumoto, Kohei, Hirata, Akira, Takaba, Akihiro, Kimura, Hiroyasu, Matsumoto, Shuhei, Higashijima, Ushio, Honda, Hiroyuki, Aoki, Nobumasa, Imai, Hiroshi, Ogino, Yasuaki, Mizuguchi, Ichiko, Ichikado, Kazuya, Nitta, Kenichi, Mochizuki, Katsunori, Hashida, Tomoaki, Tanaka, Hiroyuki, Nakamura, Tomoyuki, Niimi, Daisuke, Ueda, Takeshi, Kashiwa, Yozo, Uchiyama, Akinori, Sabelnikovs, Olegs, Oss, Peteris, Haddad, Youssef, Liew, Kong, Ñamendys-Silva, Silvio, Jarquin-Badiola, Yves, Sanchez-Hurtado, Luis, Gomez-Flores, Saira, Marin, Maria, Lemus, Jordana, Fierro, Jonathan, Cervantes, Mavy, Mejia, Francisco, Dector, Dulce M., Gonzalez, Daniel, Estrella, Claudia, Sanchez-Medina, Jorge, Ramirez-Gutierrez, Alvaro, George, Fernando, Aguirre, Janet, Buensuseso, Juan, Poblano, Manuel, Dendane, Tarek, Zeggwagh, Amine, Balkhi, Hicham, Elkhayari, Mina, Samkaoui, Nacer, Ezzouine, Hanane, Benslama, Abdellatif, Amor, Mourad, Maazouzi, Wajdi, Cimic, Nedim, Beck, Oliver, Bruns, Monique, Schouten, Jeroen, Rinia, Myra, Raaijmakers, Monique, Heunks, Leo, Van Wezel, Hellen, Heines, Serge, Strauch, Ulrich, Simonis, Fabienne, Goodson, Jennifer, Browne, Troy, Navarra, Leanlove, Hunt, Anna, Hutchison, Robyn, Bailey, Mathew, Newby, Lynette, Mcarthur, Colin, Kalkoff, Michael, Mcleod, Alex, Casement, Jonathan, Hacking, Danielle, Andersen, Finn, Dolva, Merete, Laake, Jon, Barratt-Due, Andreas, Noremark, Kim, Søreide, Eldar, Sjøbø, Brit, Guttormsen, Anne, Yoshido, Hector, Aguilar, Ronald, Oscanoa, Fredy, Alisasis, Alain, Robles, Joanne, Pasanting-Lim, Rossini, Tan, Beatriz, Andruszkiewicz, Pawel, Jakubowska, Karina, Coxo, Cristina, Alvarez, António, Oliveira, Bruno, Montanha, Gustavo, Barros, Nelson, Pereira, Carlos, Messias, António, Monteiro, Jorge, Araujo, Ana, Catorze, Nuno, Marum, Susan, Bouw, Maria, Gomes, Rui, Brito, Vania, Castro, Silvia, Estilita, Joana, Barros, Filipa, Serra, Isabel, Martinho, Aurelia, Tomescu, Dana, Marcu, Alexandra, Bedreag, Ovidiu, Papurica, Marius, Corneci, Dan, Negoita, Silvius, Grigoriev, Evgeny, Gritsan, Alexey, Gazenkampf, Andrey, Almekhlafi, Ghaleb, Albarrak, Mohamad, Mustafa, Ghanem, Maghrabi, Khalid, Salahuddin, Nawal, Aisa, Tharwat, Al Jabbary, Ahmed, Tabhan, Edgardo, Arabi, Yaseen, Trinidad, Olivia, Al Dorzi, Hasan, Bolon, Stefan, Smith, Oliver, Mancebo, Jordi, Aguirre-Bermeo, Hernan, Lopez-Delgado, Juan, Esteve, Francisco, Rialp, Gemma, Forteza, Catalina, De Haro, Candelaria, Albaiceta, Guillermo, De Cima-Iglesias, Sara, Seoane-Quiroga, Leticia, Ceniceros-Barros, Alexandra, Ruiz-Aguilar, Antonio, Claraco-Vega, Luis, Soler, Juan, del Carmen Lorente, Maria, Hermosa, Cecilia, Gordo, Federico, Prieto-González, Miryam, López-Messa, Juan, Perez, Manuel, Perez, Cesar, Allue, Raquel, Roche-Campo, Ferran, Ibañez-Santacruz, Marcos, Temprano, Susana, Pintado, Maria, De Pablo, Raul, Gómez, Pilar, Ruiz, Silvia, Moles, Silvia, Jurado, Teresa, Arizmendi, Alfons, Piacentini, Enrique, Franco, Nieves, Honrubia, Teresa, Cheng, Meisy, Losada, Elena, Blanco, Javier, Yuste, Luis, Carbayo-Gorriz, Cecilia, Cazorla-Barranquero, Francisca, Alonso, Javier, Alda, Rosa, Algaba, Ángela, Navarro, Gonzalo, Cereijo, Enrique, Diaz-Rodriguez, Esther, Marcos, Diego, Montero, Laura, Para, Luis, Sanchez, Roberto, Navalpotro, Miguel, Abad, Ricardo, González, Raquel, Toribio, Dácil, Castro, Alejandro, Artiga, Maria, Penuelas, Oscar, Roser, Tomas, Olga, Moreno, Curto, Elena, Sánchez, Rocío, Imma, Vallverdu, Elisabet, Garcia, Claverias, Laura, Magret, Monica, Pellicer, Ana, Rodriguez, Lucia, Sánchez-Ballesteros, Jesús, González-Salamanca, Ángela, Jimenez, Antonio, Huerta, Francisco, Diaz, Juan, Lopez, Esther, Moya, David, Alfonso, Alec, Luis, Palazon, Cesar, Palazon, Rafael, Sánchez, Virgilio, Corcoles, Recio, Noelia, Adamsson, Richard, Rylander, Christian, Holzgraefe, Bernhard, Broman, Lars, Wessbergh, Joanna, Persson, Linnea, Schiöler, Fredrik, Kedelv, Hans, Tibblin, Anna, Appelberg, Henrik, Hedlund, Lars, Helleberg, Johan, Eriksson, Karin, Glietsch, Rita, Larsson, Niklas, Nygren, Ingela, Nunes, Silvia, Morin, Anna-Karin, Kander, Thomas, Adolfsson, Anne, Zender, Hervé, Leemann-Refondini, Corinne, Elatrous, Souheil, Bouchoucha, Slaheddine, Chouchene, Imed, Ouanes, Islem, Souissi, Asma, Kamoun, Salma, Demirkiran, Oktay, Aker, Mustafa, Erbabacan, Emre, Ceylan, Ilkay, Girgin, Nermin, Ozcelik, Menekse, Ünal, Necmettin, Meco, Basak, Akyol, Onat, Derman, Suleyman, Kennedy, Barry, Parhar, Ken, Srinivasa, Latha, McAuley, Danny, Hopkins, Phil, Mellis, Clare, Kakar, Vivek, Hadfield, Dan, Vercueil, Andre, Bhowmick, Kaushik, Humphreys, Sally, Ferguson, Andrew, Mckee, Raymond, Raj, Ashok, Fawkes, Danielle, Watt, Philip, Twohey, Linda, Jha, Rajeev, Thomas, Matthew, Morton, Alex, Kadaba, Varsha, Smith, Mark, Hormis, Anil, Kannan, Santhana, Namih, Miriam, Reschreiter, Henrik, Camsooksai, Julie, Kumar, Alek, Rugonfalvi, Szabolcs, Nutt, Christopher, O'Neill, Orla, Seasman, Colette, Dempsey, Ged, Scott, Christopher, Ellis, Helen, MckKechnie, Stuart, Hutton, Paula, Di Tomasso, Nora, Vitale, Michela, Griffin, Ruth, Dean, Michael, Cranshaw, Julius, Willett, Emma, Ioannou, Nicholas, Gillis, Sarah, Csabi, Peter, Macfadyen, Rosaleen, Dawson, Heidi, Preez, Pieter, Williams, Alexandra, Boyd, Owen, De Gordoa, Laura, Bramall, Jon, Symmonds, Sophie, Chau, Simon, Wenham, Tim, Szakmany, Tamas, Toth-Tarsoly, Piroska, McCalman, Katie, Alexander, Peter, Stephenson, Lorraine, Collyer, Thomas, Chapman, Rhiannon, Cooper, Raphael, Allan, Russell, Sim, Malcolm, Wrathall, David, Irvine, Donald, Zantua, Kim, Adams, John, Burtenshaw, Andrew, Sellors, Gareth, Welters, Ingeborg, Williams, Karen, Hessell, Robert, Oldroyd, Matthew, Battle, Ceri, Pillai, Suresh, Kajtor, Istvan, Sivashanmugavel, Mageswaran, O'Kane, Sinead, Donnelly, Adrian, Frigyik, Aniko, Careless, Jon, May, Martin, Stewart, Richard, Trinder, T. John, Hagan, Samantha, Wise, Matt, Cole, Jade, MacFie, Caroline, Dowling, Anna, Nin, Nicolás, Nuñez, Edgardo, Pittini, Gustavo, Rodriguez, Ruben, Imperio, María, Santos, Cristina, França, Ana, Ebeid, Alejandro, Deicas, Alberto, Serra, Carolina, Uppalapati, Aditya, Kamel, Ghassan, Banner-Goodspeed, Valerie, Beitler, Jeremy, Mukkera, Satyanarayana, Kulkarni, Shreedhar, Lee, Jarone, Mesar, Tomaz, Shinn, John, Gomaa, Dina, Tainter, Christopher, Yeatts, Dale, Warren, Jessica, Lanspa, Michael, Miller, Russel, Grissom, Colin, Brown, Samuel, Bauer, Philippe, Gosselin, Ryan, Kitch, Barrett, Cohen, Jason, Beegle, Scott, Gueret, Renaud, Tulaimat, Aiman, Choudry, Shazia, Stigler, William, Batra, Hitesh, Huff, Nidhi, Lamb, Keith, Oetting, Trevor, Mohr, Nicholas, Judy, Claine, Saito, Shigeki, Kheir, Fayez, Schlichting, Adam, Delsing, Angela, Crouch, Daniel, Elmasri, Mary, Ismail, Dina, Dreyer, Kyle, Blakeman, Thomas, Baron, Rebecca, Grijalba, Carolina, Hou, Peter, Seethala, Raghu, Aisiku, Imo, Henderson, Galen, Hou, Sen-Kuang, Owens, Robert, Schomer, Ashley, Bumbasirevic, Vesna, Jovanovic, Bojan, Surbatovic, Maja, Veljovic, Milic, Laffey, John G, Madotto, Fabiana, Pham, Tài, Bajwa, Ednan K, Lorente, Jose A, Jiménez, Juan Ignacio Silesky, McAuley, Daniel F, and Slutsky, Arthur S

Published
2017
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20. Phenotypic severity in a family with MEND syndrome is directly associated with the accumulation of potentially functional variants of cholesterol homeostasis genes

Author

María Carmen Barboza‐Cerda, Oralia Barboza‐Quintana, Gerardo Martínez‐Aldape, Raquel Garza‐Guajardo, and Miguel Angel Déctor

Subjects
ABCA1, APOA5, APOB, emopamil‐binding protein, MEND syndrome, modifier genes, Genetics, QH426-470
Abstract

Abstract Background Male EBP disorder with neurologic defects (MEND) syndrome is an X‐linked disease caused by hypomorphic mutations in the EBP (emopamil‐binding protein) gene. Modifier genes may explain the clinical variability among individuals who share a primary mutation. Methods We studied four males (Patient 1 to Patient 4) exhibiting a descending degree of phenotypic severity from a family with MEND syndrome. To identify candidate modifier genes that explain the phenotypic variability, variants of homeostasis cholesterol genes identified by whole‐exome sequencing (WES) were ranked according to the predicted magnitude of their effect through an in‐house scoring system. Results Twenty‐seven from 105 missense variants found in 45 genes of the four exomes were considered significant (−5 to −9 scores). We found a direct genotype–phenotype association based on the differential accumulation of potentially functional gene variants among males. Patient 1 exhibited 17 variants, both Patients 2 and 3 exhibited nine variants, and Patient 4 exhibited only five variants. Conclusion We conclude that APOA5 (rs3135506), ABCA1 (rs9282541), and APOB (rs679899 and rs12714225) are the most relevant candidate modifier genes in this family. Relative accumulation of the deficiencies associated with variants of these genes along with other lesser deficiencies in other genes appears to explain the variable expressivity in MEND syndrome.

Published
2019
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26. ¿Se han producido cambios en la aplicación de la ventilación mecánica en relación con la evidencia científica? Estudio multicéntrico en México

Author

M.C. Marín, J. Elizalde, A. Villagómez, U. Cerón, M. Poblano, I. Palma-Lara, J.R. Sánchez, E. Monares, A. Arellano, A. Muriel, Ó. Peñuelas, F. Frutos-Vivar, A. Esteban, F. Aguilera Almazán, M. Benítez Cortázar, R. Carrillo Speare, R. Castaño, R. Corral, D.N. D́Ector Lira, G. Díaz Polanco, J.J. Elizalde, R. Envila Fisher, G. Franco, P. García Balbuena, O. Gayoso Cruz, L. Green, J.O. Herrera Hoyos, J. Hinojosa, J. Huerta, V.A. Juárez, M. Loera, C. López Alzate, E. López Mora, S. Martínez Caro, R. Méndez Reyes, M. Mendoza, O. Narváez Porras, E. Ortiz, A. Padua, V. Pureco Reyes, W. Querevalum, A. Quesada, A. Ramírez Rivera, A. Tamariz, A. Vargas, C. Vázquez, P. Cerda, R. Mercado, J. Albe Castañón, A.J. Villagómez Ortiz, C. Cruz Lozano, Z. Maycotte Luna, F. López Bacal, G. Cueto Robledo, M.A. Treviño Salinas, R. Martínez Zubieta, C. Olvera-Guzmán, Marco Montes de Oca, S.A. Ñamendys-Silva, J.S. Martínez Cano, J.A. Baltazar Torres, G. Morales Muñoz, A. Villa Delgado, J. Ladape Martínez, A. Ortega Pérez, A. Chávez Morales, A. García Luna, A. Rugiero Cabrera, A. Rugerio Cabrera, Á.A. Pérez-Calatayud, A. Velasco Gutiérrez, A.J. Longino Gómez, Antonio Tamariz Becerra Álvarez Calderón, R. Álvarez Calderón Christus Mugerza, C.I. Reynoso Estrella, D. Déctor-Lira Espindola-Cruz, D. Gutiérrez-Zárate, D. Esmeralda, E.D. Anica Malagón, E. Monares Zepeda, E. Deloya, E. Manzo Palacios, F. de Jesús Montelongo, F.J. Flores Mejía, M. Ramírez Cervantes, G. Camarena Alejo, G. Vázquez de Anda, H. Vázquez, C. Larios Luna, S.E. Zamora, G. Magaña Solano, J.I. Sánchez González, J. Rosendo Sánchez Medina, J.J. Zaragoza, J.A. Buensuseso Alfaro, J.C. Dávila Fernández, J.C. Mijangos-Méndez, M. Martínez Medina, M. Chacón Gómez, M.V. Calyeca Sánchez, J.J. Martínez Soria, R.J. García Graullera, R. Rosas, S. Sanjuana Gómez Flores, S. Reyes Inurrigarro, S.A. Ñamendy-Silva, L.A. Sánchez Hurtado, L.L. Villegas Castellanos, L. Zalatiel Maycotte, A. Estrada Gutiérrez, and M.A. León

Subjects
03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, business.industry, Medicine, 030208 emergency & critical care medicine, Critical Care and Intensive Care Medicine, business, Humanities
Abstract

Resumen Objetivo Los objetivos principales son describir la practica de la ventilacion mecanica en un periodo de 18 anos en Mexico y estimar los cambios en la mortalidad de los pacientes criticos con ventilacion mecanica invasiva (VMI). Diseno Subanalisis retrospectivo de un estudio prospectivo y observacional en 1998, 2004, 2010 y 2016. Ambito Unidades de Cuidados Intensivos (UCI) de Mexico. Participantes Pacientes adultos que ingresaron consecutivamente en la UCI, durante un mes y que recibieron VMI durante mas de 12 h o ventilacion mecanica no invasiva durante mas de una hora. El seguimiento se realizo hasta 28 dias despues de la inclusion. Intervenciones Ninguna. Variables de interes Edad, sexo, gravedad al ingreso estimada por el SAPS II, parametros de la gasometria arterial diaria, variables de tratamiento y complicaciones, fecha y estado al alta de la UCI y del hospital. Resultados Se incluyo a 959 pacientes en 81 UCI. El volumen corriente (VC) ha disminuido significativamente tanto en pacientes con criterios de SDRA (de 8,5 ml/kg de peso estimado en 1998 a 6 ml/kg en 2016; p Conclusiones La practica clinica de la VMI en las UCI de Mexico se ha modificado a lo largo de un periodo de 18 anos. El cambio mas significativo es la estrategia ventilatoria basada en VC bajos. Estos cambios no se han asociado a cambios significativos en la mortalidad.

Published
2020

27. Have there been changes in the application of mechanical ventilation in relation to scientific evidence? A multicenter observational study in Mexico

Author

M.C. Marín, J. Elizalde, A. Villagómez, U. Cerón, M. Poblano, I. Palma-Lara, J.R. Sánchez, E. Monares, A. Arellano, A. Muriel, Ó. Peñuelas, F. Frutos-Vivar, A. Esteban, F. Aguilera Almazán, M. Benítez Cortázar, R. Carrillo Speare, R. Castaño, R. Corral, D.N. D’Ector Lira, G. Díaz Polanco, J.J. Elizalde, R. Envila Fisher, G. Franco, P. García Balbuena, O. Gayoso Cruz, L. Green, J.O. Herrera Hoyos, J. Hinojosa, J. Huerta, V.A. Juárez, M. Loera, C. López Alzate, E. López Mora, S. Martínez Caro, R. Méndez Reyes, M. Mendoza, O. Narváez Porras, E. Ortiz, A. Padua, V. Pureco Reyes, W. Querevalum, A. Quesada, A. Ramírez Rivera, A. Tamariz, A. Vargas, C. Vázquez, P. Cerda, R. Mercado, J. Albe Castañón, A.J. Villagómez Ortiz, C. Cruz Lozano, Z. Maycotte Luna, F. López Bacal, G. Cueto Robledo, M.A. Treviño Salinas, R. Martínez Zubieta, C. Olvera-Guzmán, Marco Montes de Oca, S.A. Ñamendys-Silva, J.S. Martínez Cano, J.A. Baltazar Torres, G. Morales Muñoz, A. Villa Delgado, J. Ladape Martínez, A. Ortega Pérez, A. Chávez Morales, A. García Luna, A. Rugiero Cabrera, A. Rugerio Cabrera, Á.A. Pérez-Calatayud, A. Velasco Gutiérrez, A.J. Longino Gómez, Antonio Tamariz Becerra Álvarez Calderón, R. Álvarez Calderón Christus Mugerza, C.I. Reynoso Estrella, D. Déctor-Lira Espindola-Cruz, D. Gutiérrez-Zárate, D. Esmeralda, E.D. Anica Malagón, E. Monares Zepeda, E. Deloya, E. Manzo Palacios, F. de Jesús Montelongo, F.J. Flores Mejía, M. Ramírez Cervantes, G. Camarena Alejo, G. Vázquez de Anda, H. Vázquez, C. Larios Luna, S.E. Zamora, G. Magaña Solano, J.I. Sánchez González, J. Rosendo Sánchez Medina, J.J. Zaragoza, J.A. Buensuseso Alfaro, J.C. Dávila Fernández, J.C. Mijangos-Méndez, M. Martínez Medina, M. Chacón Gómez, M.V. Calyeca Sánchez, J.J. Martínez Soria, R.J. García Graullera, R. Rosas, S. Sanjuana Gómez Flores, S. Reyes Inurrigarro, S.A. Ñamendy-Silva, L.A. Sánchez Hurtado, L.L. Villegas Castellanos, L. Zalatiel Maycotte, A. Estrada Gutiérrez, and M.A. León

Subjects
Mechanical ventilation, ARDS, medicine.medical_specialty, business.industry, medicine.medical_treatment, 030208 emergency & critical care medicine, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, SAPS II, Intensive care, Emergency medicine, Medicine, Arterial blood, Observational study, business, Complication, Tidal volume
Abstract

Objective The main study objectives were to describe the practice of mechanical ventilation over an 18-year period in Mexico, and estimate changes in mortality among critical patients subjected to invasive mechanical ventilation (IMV). Design A retrospective subanalysis of a prospective observational study conducted in 1998, 2004, 2010 and 2016 was carried out. Setting Intensive Care Units (ICUs) in Mexico. Participants Adult patients consecutively enrolled in the ICU during one month and who underwent IMV for more than 12 h or noninvasive mechanical ventilation for more than one hour. Follow-up was performed up to a maximum of 28 days after inclusion. Interventions None. Principal variables of interest Age, sex, severity upon admission as estimated by SAPS II, parameters of daily arterial blood gases, treatment and complication variables, date and status at discharge from the ICU and from hospital. Results A total of 959 patients were included in 81 ICUs. Tidal volume (vt) decreased significantly both in patients with acute respiratory distress syndrome (ARDS) criteria (estimated 8.5 mL/kg b.w. in 1998 to 6 mL/kg in 2016; P Conclusions The clinical practice of IMV in Mexican ICUs has been modified over a period of 18 years. The most significant change is the ventilatory strategy based on low vt. These changes have not been associated with significant changes in mortality.

Published
2020

28. Evaluación de la psicoprofilaxis y del soporte emocional continuo para disminuir el índice de cesáreas

Author

Claudia Elena Déctor-Palma, Pablo Mariano González-Aldeco, Christian Byron Mera-Hernández, Elizabeth Valencia-Medina, and Christian Tejeda-Romero

Subjects
General Medicine
Abstract

Introduccion: De acuerdo con la OMS, el indice de cesareas debe ser 15-19%. En Mexico, desde el ano 2000 ha incrementado 33.7% en el sector publico y 60.4% en el privado. En la revision de Cochrane, «Apoyo continuo para las mujeres durante el parto», se reafirma: incremento en el parto vaginal espontaneo, disminucion en el uso de analgesia intraparto, el indice de cesareas y de parto instrumentado. Objetivos: Evaluar la relacion entre la psicoprofilaxis y el soporte emocional continuo para reducir el indice de cesareas. Material y metodos: Se evaluaron 380 mujeres con embarazo de termino y trabajo de parto en fase activa en el Nuevo Sanatorio Durango en el periodo de junio de 2015 a junio de 2016. La evaluacion incluia la presencia de soporte emocional continuo, psicoprofilaxis, uso de tratamientos farmacologicos y no farmacologicos para el control del dolor y su correlacion con el indice de cesareas. Resultados: La implementacion de psicoprofilaxis favorecio el soporte emocional, reduccion del uso de oxitocina y analgesicos, disminuyendo el indice de cesarea. Conclusiones: La psicoprofilaxis y el apoyo emocional continuo reducen el uso de oxitocina, bajando el porcentaje de cesareas.

Published
2019

31. Cultural indicators of personal development and wellbeing in México, Spain and Germany: a proposal for construction through feedback networks

Author

Aguirre Ochoa, Jerjes, Bravo Déctor, Jaime, Conacyt, and Instituto de Estudios Empresariales y Económicos Universidad Michoacana de San Nicolás de Hidalgo.

Subjects
Sociologia Jurídica, Cultura, public cultural policies, cultural indicators, wellbeing, human development
Abstract

The present article discusses the main proposals for constructing cultural indicators in Mexico, Spain and Germany, and contrasts them to the indicators used for gathering cultural statistics. It became clear that individual indicators of development and wellbeing have not been developed, or at least not at a level plausible for their application, though two decades have passed since Pattanaik proposed them for the area of culture. This paper offers a distinct development proposal for addressing this problem, one that is more feasible for the entities responsible for culture in their territories, that has the capacity to measure the impact of the cultural actions implemented on individuals, and that has a higher probability of obtaining results that will allow the analysis and evaluation of such actions.

Published
2020

32. La política cultural en México a partir del índice NIP

Author

Jaime Bravo Déctor and Jerjes Izcoatl Aguirre Ochoa

Subjects
ININEE-D-2020-0408, 5 [cti], Medición de impacto, Política pública cultural, Evaluación cultural
Abstract

Instituto de Investigaciones Económicas y Empresariales. Políticas Públicas Currently, in Mexico, the public Cultural Sector does not comply with the regulations that require it to evaluate for results of impact on the beneficiary like the rest of the federal public institutions of the country. Instead they use economic or management indices to correct their inability to evaluate cultural public policies according to the norm. This causes all cultural policy to be basically only government policy, even when applying participatory democratization schemes. The objective of the present investigation is oriented in the search of a viable way to evolve the current government cultural policy in a public policy that clearly focuses on solving diagnosed problems or cultural needs that the population requires for its well-being. For this purpose, the I-NIP was developed as an instrument that allows the effect achieved in the beneficiary population to be measured in each activity provided. This research is based on a qualitative analysis with exploratory transectional design with descriptive scope and the first tests indicate that the I-NIP is functional and adequate for this task, so it is possible to conceptualize and design public impact policies for the beneficiary through of the application of this evaluation tool, opening possibilities for the solution of public problems that could not be solved before. In this way, one of the major problems of the national and world cultural sector is resolved, since, starting from the I-NIP, it will be feasible to build public policies that from their design and approach can be evaluated in the impact they generate on the beneficiaries of such policies, as required by regulations. Actualmente en México el Sector Cultural público no cumple la normatividad que le obliga a evaluar por resultados de impacto en el beneficiario como el resto de las instituciones públicas federales del país. Utilizan en cambio índices económicos o de gestión para subsanar su incapacidad de evaluar las políticas públicas culturales de acuerdo a la norma. Esto provoca que toda la política cultural sea básicamente solo política de gobierno, incluso cuando aplica esquemas de democratización participativa. El objetivo de la presente investigación está orientado en la búsqueda de una manera viable para evolucionar la política cultural de gobierno actual en una política pública que claramente se enfoque en resolver problemas diagnosticados o necesidades culturales que la población requiere para su bienestar. Para tal efecto se desarrolló el Í-NIP como un instrumento que permite medir en cada actividad proporcionada el efecto alcanzado en la población beneficiaria. La presente investigación parte de un análisis cualitativo con diseño transeccional exploratorio con alcance descriptivo y las primeras pruebas indican que el Í-NIP es funcional y adecuado para dicha tarea, por lo que es posible conceptualizar y diseñar políticas públicas de impacto para el beneficiario a través de la aplicación de esta herramienta de evaluación, abriendo posibilidades para la solución de problemas públicos que no podían ser resueltos con anterioridad. De esta forma se logra resolver uno de los grandes problemas del sector cultural nacional y mundial ya que, a partir del Í-NIP, será factible construir políticas públicas que desde su diseño y planteamiento puedan ser evaluadas en el impacto que generan en los beneficiarios de dichas políticas, tal y como la normatividad lo demanda.

Published
2020

34. Have there been changes in the application of mechanical ventilation in relation to scientific evidence? A multicenter observational study in Mexico

Author

Marín, M.C., primary, Elizalde, J., additional, Villagómez, A., additional, Cerón, U., additional, Poblano, M., additional, Palma-Lara, I., additional, Sánchez, J.R., additional, Monares, E., additional, Arellano, A., additional, Muriel, A., additional, Peñuelas, Ó., additional, Frutos-Vivar, F., additional, Esteban, A., additional, Aguilera Almazán, F., additional, Benítez Cortázar, M., additional, Carrillo Speare, R., additional, Castaño, R., additional, Corral, R., additional, D’Ector Lira, D.N., additional, Díaz Polanco, G., additional, Elizalde, J.J., additional, Envila Fisher, R., additional, Franco, G., additional, García Balbuena, P., additional, Gayoso Cruz, O., additional, Green, L., additional, Herrera Hoyos, J.O., additional, Hinojosa, J., additional, Huerta, J., additional, Juárez, V.A., additional, Loera, M., additional, López Alzate, C., additional, López Mora, E., additional, Martínez Caro, S., additional, Méndez Reyes, R., additional, Mendoza, M., additional, Narváez Porras, O., additional, Ortiz, E., additional, Padua, A., additional, Pureco Reyes, V., additional, Querevalum, W., additional, Quesada, A., additional, Ramírez Rivera, A., additional, Tamariz, A., additional, Vargas, A., additional, Vázquez, C., additional, Cerda, P., additional, Mercado, R., additional, Albe Castañón, J., additional, Villagómez Ortiz, A.J., additional, Cruz Lozano, C., additional, Maycotte Luna, Z., additional, López Bacal, F., additional, Cueto Robledo, G., additional, Treviño Salinas, M.A., additional, Martínez Zubieta, R., additional, Olvera-Guzmán, C., additional, Montes de Oca, Marco, additional, Ñamendys-Silva, S.A., additional, Martínez Cano, J.S., additional, Baltazar Torres, J.A., additional, Morales Muñoz, G., additional, Villa Delgado, A., additional, Ladape Martínez, J., additional, Ortega Pérez, A., additional, Chávez Morales, A., additional, García Luna, A., additional, Rugiero Cabrera, A., additional, Rugerio Cabrera, A., additional, Pérez-Calatayud, Á.A., additional, Velasco Gutiérrez, A., additional, Longino Gómez, A.J., additional, Tamariz Becerra Álvarez Calderón, Antonio, additional, Álvarez Calderón Christus Mugerza, R., additional, Reynoso Estrella, C.I., additional, Déctor-Lira Espindola-Cruz, D., additional, Gutiérrez-Zárate, D., additional, Esmeralda, D., additional, Anica Malagón, E.D., additional, Monares Zepeda, E., additional, Deloya, E., additional, Manzo Palacios, E., additional, de Jesús Montelongo, F., additional, Flores Mejía, F.J., additional, Ramírez Cervantes, M., additional, Camarena Alejo, G., additional, Vázquez de Anda, G., additional, Vázquez, H., additional, Larios Luna, C., additional, Zamora, S.E., additional, Magaña Solano, G., additional, Sánchez González, J.I., additional, Rosendo Sánchez Medina, J., additional, Zaragoza, J.J., additional, Buensuseso Alfaro, J.A., additional, Dávila Fernández, J.C., additional, Mijangos-Méndez, J.C., additional, Martínez Medina, M., additional, Chacón Gómez, M., additional, Calyeca Sánchez, M.V., additional, Martínez Soria, J.J., additional, García Graullera, R.J., additional, Rosas, R., additional, Sanjuana Gómez Flores, S., additional, Reyes Inurrigarro, S., additional, Ñamendy-Silva, S.A., additional, Sánchez Hurtado, L.A., additional, Villegas Castellanos, L.L., additional, Zalatiel Maycotte, L., additional, Estrada Gutiérrez, A., additional, and León, M.A., additional

Published
2020
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35. ¿Se han producido cambios en la aplicación de la ventilación mecánica en relación con la evidencia científica? Estudio multicéntrico en México

Author

Marín, M.C., primary, Elizalde, J., additional, Villagómez, A., additional, Cerón, U., additional, Poblano, M., additional, Palma-Lara, I., additional, Sánchez, J.R., additional, Monares, E., additional, Arellano, A., additional, Muriel, A., additional, Peñuelas, Ó., additional, Frutos-Vivar, F., additional, Esteban, A., additional, Aguilera Almazán, F., additional, Benítez Cortázar, M., additional, Carrillo Speare, R., additional, Castaño, R., additional, Corral, R., additional, D́Ector Lira, D.N., additional, Díaz Polanco, G., additional, Elizalde, J.J., additional, Envila Fisher, R., additional, Franco, G., additional, García Balbuena, P., additional, Gayoso Cruz, O., additional, Green, L., additional, Herrera Hoyos, J.O., additional, Hinojosa, J., additional, Huerta, J., additional, Juárez, V.A., additional, Loera, M., additional, López Alzate, C., additional, López Mora, E., additional, Martínez Caro, S., additional, Méndez Reyes, R., additional, Mendoza, M., additional, Narváez Porras, O., additional, Ortiz, E., additional, Padua, A., additional, Pureco Reyes, V., additional, Querevalum, W., additional, Quesada, A., additional, Ramírez Rivera, A., additional, Tamariz, A., additional, Vargas, A., additional, Vázquez, C., additional, Cerda, P., additional, Mercado, R., additional, Albe Castañón, J., additional, Villagómez Ortiz, A.J., additional, Cruz Lozano, C., additional, Maycotte Luna, Z., additional, López Bacal, F., additional, Cueto Robledo, G., additional, Treviño Salinas, M.A., additional, Martínez Zubieta, R., additional, Olvera-Guzmán, C., additional, Montes de Oca, Marco, additional, Ñamendys-Silva, S.A., additional, Martínez Cano, J.S., additional, Baltazar Torres, J.A., additional, Morales Muñoz, G., additional, Villa Delgado, A., additional, Ladape Martínez, J., additional, Ortega Pérez, A., additional, Chávez Morales, A., additional, García Luna, A., additional, Rugiero Cabrera, A., additional, Rugerio Cabrera, A., additional, Pérez-Calatayud, Á.A., additional, Velasco Gutiérrez, A., additional, Longino Gómez, A.J., additional, Tamariz Becerra Álvarez Calderón, Antonio, additional, Álvarez Calderón Christus Mugerza, R., additional, Reynoso Estrella, C.I., additional, Déctor-Lira Espindola-Cruz, D., additional, Gutiérrez-Zárate, D., additional, Esmeralda, D., additional, Anica Malagón, E.D., additional, Monares Zepeda, E., additional, Deloya, E., additional, Manzo Palacios, E., additional, de Jesús Montelongo, F., additional, Flores Mejía, F.J., additional, Ramírez Cervantes, M., additional, Camarena Alejo, G., additional, Vázquez de Anda, G., additional, Vázquez, H., additional, Larios Luna, C., additional, Zamora, S.E., additional, Magaña Solano, G., additional, Sánchez González, J.I., additional, Rosendo Sánchez Medina, J., additional, Zaragoza, J.J., additional, Buensuseso Alfaro, J.A., additional, Dávila Fernández, J.C., additional, Mijangos-Méndez, J.C., additional, Martínez Medina, M., additional, Chacón Gómez, M., additional, Calyeca Sánchez, M.V., additional, Martínez Soria, J.J., additional, García Graullera, R.J., additional, Rosas, R., additional, Sanjuana Gómez Flores, S., additional, Reyes Inurrigarro, S., additional, Ñamendy-Silva, S.A., additional, Sánchez Hurtado, L.A., additional, Villegas Castellanos, L.L., additional, Zalatiel Maycotte, L., additional, Estrada Gutiérrez, A., additional, and León, M.A., additional

Published
2020
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36. Phenotypic severity in a family with MEND syndrome is directly associated with the accumulation of potentially functional variants of cholesterol homeostasis genes

Author

Oralia Barboza-Quintana, Gerardo Martínez-Aldape, María C. Barboza-Cerda, Miguel A. Déctor, and Raquel Garza-Guajardo

Subjects
Male, 0301 basic medicine, lcsh:QH426-470, Apolipoprotein B, EMOPAMIL-BINDING PROTEIN, ABCA1, 030105 genetics & heredity, APOA5, medicine.disease_cause, Severity of Illness Index, 03 medical and health sciences, modifier genes, Genetics, medicine, Homeostasis, Humans, Missense mutation, Exome, Waardenburg Syndrome, emopamil‐binding protein, Molecular Biology, Gene, Genetic Association Studies, Genetics (clinical), Exome sequencing, Mutation, Polymorphism, Genetic, biology, Original Articles, Phenotype, lcsh:Genetics, Cholesterol, 030104 developmental biology, Apolipoprotein A-V, MEND syndrome, Apolipoprotein B-100, biology.protein, Original Article, Female, APOB, ATP Binding Cassette Transporter 1
Abstract

Background Male EBP disorder with neurologic defects (MEND) syndrome is an X‐linked disease caused by hypomorphic mutations in the EBP (emopamil‐binding protein) gene. Modifier genes may explain the clinical variability among individuals who share a primary mutation. Methods We studied four males (Patient 1 to Patient 4) exhibiting a descending degree of phenotypic severity from a family with MEND syndrome. To identify candidate modifier genes that explain the phenotypic variability, variants of homeostasis cholesterol genes identified by whole‐exome sequencing (WES) were ranked according to the predicted magnitude of their effect through an in‐house scoring system. Results Twenty‐seven from 105 missense variants found in 45 genes of the four exomes were considered significant (−5 to −9 scores). We found a direct genotype–phenotype association based on the differential accumulation of potentially functional gene variants among males. Patient 1 exhibited 17 variants, both Patients 2 and 3 exhibited nine variants, and Patient 4 exhibited only five variants. Conclusion We conclude that APOA5 (rs3135506), ABCA1 (rs9282541), and APOB (rs679899 and rs12714225) are the most relevant candidate modifier genes in this family. Relative accumulation of the deficiencies associated with variants of these genes along with other lesser deficiencies in other genes appears to explain the variable expressivity in MEND syndrome.

Published
2019

37. Evidence of DENV-2 Vertical Transmission in LarvalAedes aegyptiPopulations at Cancun, Quintana Roo, Mexico

Author

Rosa M. Sanchez-Casas, Jaime Salomón Grajales, Miguel A. Déctor, Alejandro Gaitan-Burns, Ildefonso Fernández-Salas, and Esteban E. Díaz-González

Subjects
Serotype, Veterinary medicine, Larva, Ecology, biology, fungi, 030231 tropical medicine, Yellow fever, Aedes aegypti, Dengue virus, medicine.disease_cause, medicine.disease, biology.organism_classification, Virology, Infection rate, law.invention, 03 medical and health sciences, 0302 clinical medicine, Transmission (mechanics), law, Insect Science, parasitic diseases, medicine, 030212 general & internal medicine, Agronomy and Crop Science
Abstract

Evidence of vertical transmission of dengue virus (DENV) in yellow fever mosquito, Aedes aegypti (L.), was found at Cancun, Quintana Roo, Mexico. Ae. aegypti larvae were collected from 729 containers in a total of 178 households between September and November 2012. Larvae collected were put into sterile bags and transported in thermoses. RT-PCR followed by semi-nested PCR for molecular serotyping was used to evaluate for dengue virus in larval pools. Of the 178 houses sampled, 79 (44.4%) were positive for at last one Ae. aegypti larva. The positive breeding sites were grouped into a total of 79 pools. Only three larval pools from three houses close together were positive for DENV-2. The infection rate was 0.32 per 1,000 mosquitos (95% CI 0.09–0.85 per 1,000 mosquitoes). The result of this report suggested that vertical transmission of dengue virus in Ae. aegypti might be a mechanism of viral perpetuation during inter-epidemic periods.

Published
2016

40. An Alternative Canonical Approach to the Ghost Problem in a Complexified Extension of the Pais-Uhlenbeck Oscillator

Author

H.A. Morales-Técotl, A. Déctor, J.D. Vergara, and L.F. Urrutia

Subjects
quantum canonical transformations, higher order derivative models, Mathematics, QA1-939
Abstract

Our purpose in this paper is to analyze the Pais-Uhlenbeck (PU) oscillator using complex canonical transformations. We show that starting from a Lagrangian approach we obtain a transformation that makes the extended PU oscillator, with unequal frequencies, to be equivalent to two standard second order oscillators which have the original number of degrees of freedom. Such extension is provided by adding a total time derivative to the PU Lagrangian together with a complexification of the original variables further subjected to reality conditions in order to maintain the required number of degrees of freedom. The analysis is accomplished at both the classical and quantum levels. Remarkably, at the quantum level the negative norm states are eliminated, as well as the problems of unbounded below energy and non-unitary time evolution. We illustrate the idea of our approach by eliminating the negative norm states in a complex oscillator. Next, we extend the procedure to the Pais-Uhlenbeck oscillator. The corresponding quantum propagators are calculated using Schwinger's quantum action principle. We also discuss the equal frequency case at the classical level.

Published
2009
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41. Manejo del paciente críticamente enfermo.

Author

Gutiérrez-García, Alberto, Hidalgo-Ponce, Alejandro, Arellano-Ramírez, Alfredo, Sierra-Unzueta, Alfredo, Hernán González-Molina, Amaury, Blanco-Montero, Andrés, Carlos Bassols-Ricárdez, Ángel, Villagómez-Ortiz, Asisclo, Pérez-Calatayud, Augusto, Margarita Hernández-Cárdenas, Carmen, Cruz-Lozano, César, Montserrat Cuéllar, Cinthia, Ivette Olvera-Guzmán, Claudia, María Déctor-Lira, Dulce, Vidal-Andrade, Erick, Monares-Zepeda, Enrique, Ramírez-Gutiérrez, Enrique, Olivares-Durán, Enrique, Vergara-Chávez, Enrique, and López-Baca, Francisco

Published
2020
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43. Adherence inhibition of Streptococcus mutans on dental enamel surface using silver nanoparticles

Author

León Francisco Espinosa-Cristóbal, E.J. Téllez-Déctor, Nereyda Niño-Martínez, N.V. Zavala-Alonso, Gabriel Alejandro Martínez-Castañón, and Juan Pablo Loyola-Rodríguez

Subjects
Silver, Materials science, Light, Surface Properties, Scanning electron microscope, Metal Nanoparticles, Negative control, Bioengineering, Microbial Sensitivity Tests, Antibacterial effect, Microscopy, Atomic Force, Bacterial Adhesion, Silver nanoparticle, Microbiology, Streptococcus mutans, Biomaterials, Microscopy, Humans, Scattering, Radiation, Dental Enamel, biology, Atomic force microscopy, Dental enamel, biology.organism_classification, Mechanics of Materials, Nuclear chemistry
Abstract

The aim of this ex vivo study was to evaluate the adherence capacity of Streptococcus mutans after being exposed to three different sizes of silver nanoparticles on healthy human dental enamel. Three different sizes of silver nanoparticles (9.3, 21.3 and 98 nm) were prepared, characterized and an adherence testing was performed to evaluate their anti-adherence activity on a reference strain of S. mutans on healthy dental enamel surfaces. Colony-Forming Unit count was made for adherence test and light microscopy, atomic force microscopy and scanning electron microscopy were used to compare qualitative characteristics of S. mutans. 9.3 nm and 21.3 nm groups did not show differences between them but statistical differences were found when 9.3 nm and 21.3 nm groups were compared with 98 nm and negative control groups (p

Published
2013

44. A novel phenotype characterized by digital abnormalities, intellectual disability, and short stature in a Mexican family maps to Xp11.4-p11.21

Author

María C. Barboza-Cerda, Laura Elia Martínez-de-Villarreal, Miguel A. Déctor, Roberto Rangel, and Luis Daniel Campos-Acevedo

Subjects
Adult, Male, Dwarfism, Genes, Recessive, Biology, Short stature, X-inactivation, Diagnosis, Differential, Fingers, Young Adult, Genes, X-Linked, X Chromosome Inactivation, Intellectual Disability, Intellectual disability, Genetics, medicine, Humans, Abnormalities, Multiple, Copy-number variation, Mexico, Genetics (clinical), X chromosome, Chromosomes, Human, X, Brachydactyly, Haplotype, Chromosome Mapping, Middle Aged, Toes, medicine.disease, Pedigree, Phenotype, Haplotypes, Molecular Diagnostic Techniques, Female, Lod Score, medicine.symptom
Abstract

The family observed in this study included affected males and asymptomatic females. The patients shared specific digital abnormalities including postaxial polydactyly, cutaneous syndactyly, and brachydactyly. In addition, the patients exhibited mild-to-moderate intellectual disability and short stature coupled with microbrachycephaly, scoliosis, and cerebellar and renal hypoplasia. No chromosomal alterations or copy number variations were found in the index case. The genetic linkage analysis, which focused on the X chromosome, and the haplotype analysis detected a ~15.74 Mb candidate region located at Xp11.4-p11.21 with a LOD score of 4.8. Additionally, half of the mothers showed skewed X-inactivation, while the other mothers exhibited random inactivation patterns. The candidate region includes 28 protein-encoding genes that have not yet been implicated in human disorders. We speculate that the observed phenotype is compatible with a monogenic disorder in which the mutant gene plays a significant role during embryonic development. Based on the patients' clinical features, image studies, pedigree, chromosome location, and X-inactivation studies in the mothers, we propose that this family has a novel, specific syndrome with an X-linked recessive mode of inheritance.

Published
2013

45. Comparative Responses of Anastrepha ludens and Anastrepha obliqua (Diptera: Tephritidae) to the Synthetic Attractant BioLure

Author

Pablo Liedo, Julio C. Rojas, Nayeli Déctor, and Edi A. Malo

Subjects
0106 biological sciences, Male, Ecology, biology, Chemotaxis, Significant difference, Tephritidae, Zoology, General Medicine, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Insect Control, Pheromones, Electroantennography, Toxicology, 010602 entomology, Anastrepha obliqua, Species Specificity, Insect Science, Animals, Female, Anastrepha ludens, Orchard
Abstract

The responses of wild and sterile Anastrepha ludens (Loew) and Anastrepha obliqua (Mcquart) fruit flies to the synthetic attractant BioLure were determined by electroantennography (EAG), in field cage tests using MultiLure traps, and by release–recapture field experiments using sterile flies. In EAG bioassays, no differences were found between species, sexes, sterile and wild flies. There were only specific differences and interactions in dose responses. More A. ludens than A. obliqua individuals were captured in multilure traps in field cage test. In A. ludens , there was not significant difference between the number of females and males captured, whereas in A. obliqua more females than males were caught. Age showed a bimodal response in both species and both sexes, with peaks at 4 and 14 d old. In the release–recapture experiments, there were significant differences between species, sexes, and orchards and among the days after release. More individuals of A. luden s than A . obliqua were recaptured. Only in A. obliqua the difference between the sexes was significant, with a 3.60:1 female:male ratio. Orchard conditions affected the recapture rate, but in both orchards the largest number of flies recaptured occurred during the first day after release (46 and 88% in each orchard). Our results show that the response to this synthetic lure is species-specific and contribute to better interpret trapping data.

Published
2016

46. Comparación de las respuestas de Anastrepha ludens y Anastrepha obliqua (Díptera: Tephritidae) al atrayente sintético BioLure

Author

Nayeli Déctor Pacheco, Pablo Liedo, Julio Rojas, and Malo Edi

Subjects
Moscas de la fruta, Anastrepha ludens, Anastrepha obliqua, Atrayentes, BioLure, Control de plagas [Tesauro], 24 [cti], Fruit flies, Attractants, Pest control [Tesauro], 2 [cti]
Abstract

Resumen en español: "El género Anastrepha (Schiner) es considerado el grupo más diverso de especies de la familia Tephritidae en América (Hernández-Ortiz 2003). En México se reportan 37 especies de Anastrepha, de las cuales únicamente cuatro son consideradas de importancia económica: Anastrepha ludens (Loew) que ataca a cítricos (Citrus spp. L.) y mango (Mangifera indica L.); A. obliqua (Mcquart) que infesta mango y diversas especies de jobos o ciruelas (Spondias spp); A. serpentina (Wiedemann) que ataca a las sapotáceas como el mamey (Calocarpum mammosum L.) y chicozapote (Manilkara zapota L.), y A. striata (Schiner) principal plaga de la guayaba (Psidium guajava L.) (Hernández-Ortiz y Aluja 1993). Los climas tropicales y subtropicales favorecen la existencia de una gran cantidad de especies vegetales que son hospederas de las moscas de la fruta. La naturaleza polífaga de estas plagas permite que tengan una amplia distribución en el territorio nacional, representando un alto riesgo para el sector frutícola. Esto ha generado el desarrollo de programas fitosanitarios para su control (IAEA 2003). En 1992, el gobierno federal implementó el Programa Nacional contra Moscas de la Fruta, con el objetivo de controlar, y erradicar donde fuera factible, a estas cuatro especies de importancia económica (Reyes et al. 2000). "

Published
2016

47. CULTURAL INDICATORS OF PERSONAL DEVELOPMENT AND WELLBEING IN MEXICO, SPAIN AND GERMANY: A PROPOSAL FOR CONSTRUCTION THROUGH FEEDBACK NETWORKS.

Author

Aguirre Ochoa, Jerjes and Bravo Déctor, Jaime

Abstract

Copyright of Quaestio Iuris (QI) is the property of Editora da Universidade do Estado do Rio de Janeiro (EdUERJ) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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48. Evaluación de la psicoprofilaxis y del soporte emocional continuo para disminuir el índice de cesáreas.

Author

Elena Déctor-Palma, Claudia, Byron Mera-Hernández, Christian, Valencia-Medina, Elizabeth, Tejeda-Romero, Christian, and Mariano González-Aldeco, Pablo

Abstract

Introduction: According to the WHO, the Caesarean Index should be 15-19%. In Mexico, since 2000 it has increased 33.7% in the public sector and 60.4% in the private sector. In the Cochrane review, «Continuous support for women during childbirth» reaffirms: increase in spontaneous vaginal delivery, decrease in the use of intrapartum analgesia, the rate of caesarean sections and instrumented delivery. Objectives: To evaluate the relationship between psychoprophylaxis and continuous emotional support to reduce the caesarean index. Material and methods: We evaluated 380 women with active pregnancy and active phase of labor at the Nuevo Sanatorio Durango in the period from June 2015 to June 2016. The evaluation included the presence of continuous emotional support, psycho-prophylaxis, use of pharmacological treatments and non-pharmacological for pain control and its correlation with the caesarean index. Results: The implementation of psychoprophylactics favored emotional support, reduced use of oxytocin and analgesics, decreasing the rate of caesarean section. Conclusions: Psychoprophylaxis and continuous emotional support decrease the use of oxytocin, decreasing the percentage of caesareans. [ABSTRACT FROM AUTHOR]

Published
2019
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49. RNA silencing of rotavirus gene expression

Author

Tomás López, Lorenzo Segovia, Rafaela Espinosa, Carlos F. Arias, Minerva Camacho, Miguel A. Déctor, Pavel Isa, and Susana López

Subjects
Gene Expression Regulation, Viral, Rotavirus, Cancer Research, Small interfering RNA, Genes, Viral, RNA-induced transcriptional silencing, RNA-induced silencing complex, RNA Stability, viruses, Trans-acting siRNA, Biology, Reoviridae, Article, RNA interference, DNA-directed RNA interference, Virology, Gene silencing, RNA, Small Interfering, fungi, siRNAs, RNA silencing, Antiviral agents, Infectious Diseases, RNA, Viral
Abstract

RNA interference (RNAi) is a double-stranded RNA (dsRNA)-triggered mechanism for suppressing gene expression, which is conserved in evolution and has emerged as a powerful tool to study gene function. Rotaviruses, the leading cause of severe diarrhea in young children, are formed by three concentric layers of protein, and a genome composed of 11 segments of dsRNA. Here, we show that the RNAi machinery can be triggered to silence rotavirus gene expression by sequence-specific short interfering RNAs (siRNAs). RNAi is also useful for the study of the virus-cell interactions, through the silencing of cellular genes that are potentially important for the replication of the virus. Interestingly, while the translation of mRNAs is readily stopped by the RNAi machinery, the viral transcripts involved in virus genome replication do not seem to be susceptible to RNAi. Since gene silencing by RNAi is very efficient and specific, this system could become a novel therapeutic approach for rotavirus and other virus infections, once efficient methods for in vivo delivery of siRNAs are developed. Although the use of RNAi as an antiviral therapeutic tool remains to be demonstrated, there is no doubt that this technology will influence drastically the way postgenomic virus research is conducted.

Published
2004

50. Detection of Hepatitis B Virus in Seropositive and Seronegative Patients with Chronic Liver Disease Using DNA Amplification by PCR

Author

Linda E. Muñoz-Espinosa, Miguel Ángel Déctor-Carrillo, Francisco Javier Martínez-Martínez, Isaías Balderas-Rentería, and Hugo A. Barrera-Saldaña

Subjects
Hepatitis B virus, Hepatitis B virus DNA polymerase, Hepatitis C virus, Enzyme-Linked Immunosorbent Assay, Biology, medicine.disease_cause, Polymerase Chain Reaction, law.invention, Serology, law, medicine, Humans, Mexico, Polymerase chain reaction, DNA Primers, Liver Diseases, General Medicine, Hepatitis B, medicine.disease, Virology, HBeAg, DNA, Viral, Immunology, Primer (molecular biology)
Abstract

Background The aim of this study was to detect DNA of hepatitis B virus (HBV) for reliable diagnosis of HBV infection in sera by means of a validated polymerase chain reaction (PCR) using a 5′ oligonucleotide (primer) previously described and a 3′ primer designed by our investigation group. Methods Sera samples collected from patients with chronic liver disease (CLD) related to HBV infection and negative to hepatitis C virus (HCV) infection were analyzed. Patients were both positive and negative to HBV by serum markers detected by ELISA immunoassay. A 146-base pair (bp) fragment was amplified from highly conserved precore-core region. This procedure enabled us to search for DNA HBV-positive cases. Results Viral replicative state in negative hepatitis B e antigen (HBeAg) (15.7%) cases was verified by PCR technique. This detected infection by HBV in 100% of immunoassay-positive samples. Additionally, sequences of expected size in patients bearing atypical markers in their sera (7.1%) and those with negative serology (4.8%) for HBV markers were detected. Conclusions In this study we have improved a PCR technique successfully applied in hepatitis B prevalence studies in northeastern Mexico. Prevalence of hepatitis B in this region of Mexico is intermediate compared to countries of the northern hemisphere where prevalence is lower, and to countries of Southeast Asia and the Mediterranean region where it is highly endemic.

Published
2002

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