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4 results on '"Cytotoxic antibody test"'

2. Immune Adherence of Leucocytes and Fibroblasts Derived from Skin, Sensitized by Cytotoxic Leucocyte Iso-Antibodies and Complement, to the Surface of Indicator Cells

Author

C. P. Engelfriet, C. J. M. Melief, J. J. Loghem, and Mia van der Hart

Subjects
biology, Antigen-antibody reactions, Dye exclusion, Immune adherence, Human skin, Complement System Proteins, Hematology, General Medicine, Fibroblasts, Cytotoxic antibody test, Antigen-Antibody Reactions, Isoantibodies, Agglutination Tests, Immunology, Leukocytes, biology.protein, Animals, Humans, Cytotoxic T cell, Lymphocytes, Rabbits, Antibody, Skin
Abstract

Summary Evidence was found that human lymphocytes and fibroblasts derived from human skin, sensitized by cytotoxic leucocyte iso-antibodies and complement adhere to the surface of indicator cells. The reaction mechanism showed the characteristics of the immune adherence (I.A.) phenomenon. Experiments made clear that in the I.A. assay the same antibody is detected as in the cytotoxic antibody test, based on dye exclusion. The sensitivity of the I.A. assay was shown to surpass slightly that of the cytotoxic antibody test.

Published
1967
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3. HL-A antigens on human granulocytes studied with cytotoxic iso-antisera obtained by skin grafting

Author

Erik Thorsby

Subjects
Male, Isoantigens, Erythrocytes, medicine.medical_treatment, Hl a antigens, Absorption (skin), Biology, Absorption, Antigen, Pregnancy, Transplantation Immunology, medicine, Leukocytes, Cytotoxic T cell, Animals, Humans, Lymphocytes, Pan-T antigens, Molecular Biology, Antiserum, Immune Sera, Hematology, Complement System Proteins, Skin Transplantation, Trypan Blue, Cytotoxic antibody test, Molecular biology, Immunology, Skin grafting, Female, Rabbits
Abstract

Iso-antigens of human granulocytes were studied with some HL-A antisera obtained by skin grafting. The granulocytes gave no reaction in the cytotoxic antibody test, but absorption studies showed that the granulocytes contained the same HL-A antigens as the lymphocytes from the same persons, which demonstrates that HL-A antigens are common antigens of these cells. Quantitative absorption studies revealed a lower concentration and total amount of HL-A antigens on granulocytes than on lymphocytes. This may partly explain the resistance of granulocytes in the cytotoxic antibody test.

Published
1969

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