1. Antigen-specific interferon-gamma responses and innate cytokine balance in TB-IRIS
- Author
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Goovaerts, Odin, Jennes, Wim, Massinga-Loembé, Marguerite, Ceulemans, Ann, Worodria, William, Mayanja-Kizza, Harriet, Colebunders, R, Kestens, L., TB-IRIS Study Group, TBSG, Mascart, Françoise, Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Global Health, Infectious diseases, and TB-IRIS Study Grp
- Subjects
Lipopolysaccharides ,Male ,Enzyme-Linked Immunospot Assay ,Mycobacterium tuberculosis -- immunology ,medicine.medical_treatment ,Antitubercular Agents ,lcsh:Medicine ,HIV Infections ,Clinical immunology ,Interleukin-12 -- immunology -- metabolism ,urologic and male genital diseases ,Antitubercular Agents -- immunology -- therapeutic use ,Immune Reconstitution Inflammatory Syndrome ,Medicine and Health Sciences ,Interferon gamma ,Prospective Studies ,lcsh:Science ,Immune Response ,Anti-HIV Agents -- immunology -- therapeutic use ,Innate Immune System ,Multidisciplinary ,biology ,Interleukin-6 -- immunology -- metabolism ,ELISPOT ,Receptors, Interleukin-12 ,Interleukin-10 -- immunology -- metabolism ,Sciences bio-médicales et agricoles ,Cytokines -- immunology -- metabolism ,HIV immunopathogenesis ,Interleukin-12 ,female genital diseases and pregnancy complications ,Interleukin-10 ,Interleukin 10 ,Infectious Diseases ,Cytokine ,Cytomegalovirus Infections ,Cytokines ,Female ,Engineering sciences. Technology ,Research Article ,medicine.drug ,Adult ,Influenza, Human -- complications -- immunology ,Anti-HIV Agents ,Inflammatory Diseases ,Immunology ,Interferon-gamma -- immunology -- metabolism ,Immunopathology ,Opportunistic Infections ,Interferon-gamma ,Immune system ,Immune reconstitution inflammatory syndrome ,Antigen ,Influenza, Human ,Cytomegalovirus Infections -- complications -- immunology ,medicine ,Antigens, Bacterial -- immunology ,Tuberculosis ,Humans ,cardiovascular diseases ,Interleukin 6 ,Immune Reconstitution Inflammatory Syndrome -- complications -- immunology ,Inflammation ,Antigens, Bacterial ,HIV Infections -- complications -- drug therapy -- immunology ,Biology and life sciences ,Interleukin-6 ,business.industry ,urogenital system ,fungi ,lcsh:R ,Tuberculosis -- complications -- drug therapy -- immunology ,Mycobacterium tuberculosis ,Molecular Development ,medicine.disease ,Acquired Immune System ,CD4 Lymphocyte Count ,Immune System ,biology.protein ,Lipopolysaccharides -- immunology ,lcsh:Q ,business ,Developmental Biology - Abstract
Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) remains a poorly understood complication in HIV-TB patients receiving antiretroviral therapy (ART). TB-IRIS could be associated with an exaggerated immune response to TB-antigens. We compared the recovery of IFNγ responses to recall and TB-antigens and explored in vitro innate cytokine production in TB-IRIS patients., info:eu-repo/semantics/published
- Published
- 2014