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Antigen-specific interferon-gamma responses and innate cytokine balance in TB-IRIS
- Source :
- PLoS ONE, Vol 9, Iss 11, p e113101 (2014), PloS one, 9 (11, PLoS ONE, 9(11). Public Library of Science, PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) remains a poorly understood complication in HIV-TB patients receiving antiretroviral therapy (ART). TB-IRIS could be associated with an exaggerated immune response to TB-antigens. We compared the recovery of IFNγ responses to recall and TB-antigens and explored in vitro innate cytokine production in TB-IRIS patients.<br />info:eu-repo/semantics/published
- Subjects :
- Lipopolysaccharides
Male
Enzyme-Linked Immunospot Assay
Mycobacterium tuberculosis -- immunology
medicine.medical_treatment
Antitubercular Agents
lcsh:Medicine
HIV Infections
Clinical immunology
Interleukin-12 -- immunology -- metabolism
urologic and male genital diseases
Antitubercular Agents -- immunology -- therapeutic use
Immune Reconstitution Inflammatory Syndrome
Medicine and Health Sciences
Interferon gamma
Prospective Studies
lcsh:Science
Immune Response
Anti-HIV Agents -- immunology -- therapeutic use
Innate Immune System
Multidisciplinary
biology
Interleukin-6 -- immunology -- metabolism
ELISPOT
Receptors, Interleukin-12
Interleukin-10 -- immunology -- metabolism
Sciences bio-médicales et agricoles
Cytokines -- immunology -- metabolism
HIV immunopathogenesis
Interleukin-12
female genital diseases and pregnancy complications
Interleukin-10
Interleukin 10
Infectious Diseases
Cytokine
Cytomegalovirus Infections
Cytokines
Female
Engineering sciences. Technology
Research Article
medicine.drug
Adult
Influenza, Human -- complications -- immunology
Anti-HIV Agents
Inflammatory Diseases
Immunology
Interferon-gamma -- immunology -- metabolism
Immunopathology
Opportunistic Infections
Interferon-gamma
Immune system
Immune reconstitution inflammatory syndrome
Antigen
Influenza, Human
Cytomegalovirus Infections -- complications -- immunology
medicine
Antigens, Bacterial -- immunology
Tuberculosis
Humans
cardiovascular diseases
Interleukin 6
Immune Reconstitution Inflammatory Syndrome -- complications -- immunology
Inflammation
Antigens, Bacterial
HIV Infections -- complications -- drug therapy -- immunology
Biology and life sciences
Interleukin-6
business.industry
urogenital system
fungi
lcsh:R
Tuberculosis -- complications -- drug therapy -- immunology
Mycobacterium tuberculosis
Molecular Development
medicine.disease
Acquired Immune System
CD4 Lymphocyte Count
Immune System
biology.protein
Lipopolysaccharides -- immunology
lcsh:Q
business
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d71cbc86a1e10e0ad35f7b9fec53b676