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5 results on '"Cyril Ringot"'

1. Antibacterial activity of a photosensitive hybrid cellulose fabric

Author

Vincent Sol, Tan-Sothea Ouk, Cyril Ringot, Evelyne Poli, Frédérique Brégier, Naïma Saad, Vincent Chaleix, Philippe Bressollier, Chimie et Biologie des Membranes et des Nanoobjets (CBMN), École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), PEIRENE (PEIRENE), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Staphylococcus aureus, Light, Radical polymerization, Protoporphyrins, 02 engineering and technology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Microbial Sensitivity Tests, 01 natural sciences, chemistry.chemical_compound, Polymer chemistry, Escherichia coli, [CHIM]Chemical Sciences, Photosensitizer, Physical and Theoretical Chemistry, Cellulose, ComputingMilieux_MISCELLANEOUS, Photosensitizing Agents, Protoporphyrin IX, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Textiles, technology, industry, and agriculture, [CHIM.MATE]Chemical Sciences/Material chemistry, Cerium, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Anti-Bacterial Agents, chemistry, Polymerization, Methacrylic acid, Covalent bond, 0210 nano-technology, Antibacterial activity
Abstract

We report the preparation of a cellulose fabric bearing derivative protoporphyrin IX units covalently attached to the cellulose backbone of a fabric. Ce-(IV) redox system radical polymerization was used to polymerize methacrylic acid (MAA) onto a cotton material and to obtain cotton-g-polyMAA. Attachment of the photosensitizer, a protoporphyrin IX (PpIX) amino derivative, on cotton-g-polyMAA was realized successfully by a classical peptidic covalent link. The modified surfaces were characterized by ATR-FTIR, DRUV, TGA, and SEM methods. Under visible light irradiation, protoporphyrinic cotton showed antibacterial activity against Staphyloccoccus aureus. This concept is very promising in the field of bacterial decontamination (sterile area, hospital equipment, etc.).

Published
2018
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2. Triazinyl porphyrin-based photoactive cotton fabrics: preparation, characterization, and antibacterial activity

Author

Matthieu Barrière, Vincent Sol, Robert Granet, Céline Frochot, Naïma Saad, Cyril Ringot, Pierre Krausz, Pierre Couleaud, Philippe Bressollier, Laboratoire de Chimie des Substances Naturelles (LCSN), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Conseil Régional du Limousin, and Dr. Michel Guilloton and Pierre Carles (SPCTS-Limoges) for MEB Analysis

Subjects
Thermogravimetric analysis, Porphyrins, Polymers and Plastics, Light, Bioengineering, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biomaterials, chemistry.chemical_compound, Polymer chemistry, Spectroscopy, Fourier Transform Infrared, Materials Chemistry, Photosensitizer, Cotton Fiber, Cellulose, Triazine, Chemistry, Triazines, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Cationic polymerization, Chemical modification, 021001 nanoscience & nanotechnology, Porphyrin, 0104 chemical sciences, Anti-Bacterial Agents, Thermogravimetry, Microscopy, Electron, Scanning, Spectrophotometry, Ultraviolet, 0210 nano-technology, Antibacterial activity
Abstract

International audience; In the present work, we report on the synthesis of cellulose cotton fibers bearing different types of photosensitizers with the aim to prepare new efficient polymeric materials for antimicrobial applications. Anionic, neutral, and cationic amino porphyrins have been covalently grafted on cotton fabric, without previous chemical modification of the cellulosic support, using a 1,3,5-triazine derivative as the linker. The obtained porphyrin-grafted cotton fabrics were characterized by infrared (ATR-FTIR), diffuse reflectance UV-vis (DRUV) spectroscopies, and thermogravimetric analysis (TGA) to confirm the triazine linkage. Antimicrobial activity of porphyrin-cellulose materials was tested under visible light irradiation against Staphylococcus aureus and Escherichia coli . The results showed excellent activity on the Gram-positive bacterium, showing structure-activity relationship, although no photodamage of the Gram-negative microorganism was recorded. A mechanism of bacterial inactivation by photosensitive surfaces is proposed.

Published
2011
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3. Meso-functionalized aminoporphyrins as efficient agents for photo-antibacterial surfaces

Author

Naïma Saad, Robert Granet, Philippe Bressollier, Pierre Krausz, Cyril Ringot, Vincent Sol, Laboratoire de Chimie des Substances Naturelles (LCSN), and Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)

Subjects
010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, medicine.medical_treatment, Cyanuric chloride, Cationic polymerization, cyanuric chloride, antibacterial surface, Photodynamic therapy, amino porphyrin, General Chemistry, 010402 general chemistry, Antimicrobial, 01 natural sciences, 3. Good health, 0104 chemical sciences, cotton fabric, chemistry.chemical_compound, chemistry, photodynamic therapy, Proton NMR, medicine, Organic chemistry
Abstract

Anionic, neutral and cationic amino porphyrins were synthesized as precursors of photodynamic antimicrobial agents with an aim to functionalize cotton surface through 1,3,5-triazine link. Structures of porphyrin-triazine derivatives were characterized by 1H NMR, MS and UV-vis confirming the feasibility of this novel concept. Porphyrinic cotton fabrics have been developed from these derivatives, and tested in vitro against Staphylococcus aureus. These novel photodynamic surfaces showed strong and varied antimicrobial activity.

Published
2010
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4. Synthesis of tetraglucosyl- and tetrapolyamine-tetrabenzoporphyrin conjugates for an application in PDT

Author

Florian Ménard, Pierre Krausz, Caroline Le Morvan, Yves Queneau, Cyril Ringot, Sandra Alves, Noboru Ono, Vincent Sol, Robert Granet, Laboratoire de Chimie des Substances Naturelles (LCSN), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Synthèse, Structure et Fonction de Molécules Bioactives (SSFMB), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chimie Organique et Bioorganique (COB), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Department of chemistry, Ehime University [Matsuyama], Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Ehime University [Matsuyama, Japon]

Subjects
Porphyrins, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Photodynamic therapy, Breast Neoplasms, 010402 general chemistry, 01 natural sciences, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Benzene Derivatives, Polyamines, Animals, Humans, Porfimer sodium, Photosensitizer, skin and connective tissue diseases, Cytotoxicity, Molecular Biology, Photosensitizing Agents, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, fungi, 0104 chemical sciences, 3. Good health, carbohydrates (lipids), HaCaT, Glucose, chemistry, Models, Chemical, Photochemotherapy, Cancer cell, Molecular Medicine, Biological Assay, Female, Polyamine, medicine.drug
Abstract

International audience; This paper reports the synthesis and characterization of a new class of tetrabenzoporphyrins bearing glucosyl or polyamine units on meso positions to improve the targeting of cancer cells. Photocytotoxic activity of these photosensitizers was tested on cell lines HaCaT and MCF-7 and compared to Photofrin II.

Published
2009
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5. Porphyrin-grafted cellulose fabric: New photobactericidal material obtained by 'Click-Chemistry' reaction

Author

Cyril Ringot, Pierre Krausz, Robert Granet, Vincent Sol, Laboratoire de Chimie des Substances Naturelles (LCSN), and Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)

Subjects
Textile, Materials science, 02 engineering and technology, Antibacterial surface, 010402 general chemistry, 01 natural sciences, Porphyrin, chemistry.chemical_compound, Cotton fabric, Organic chemistry, General Materials Science, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Cellulose, Click-Chemistry, business.industry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Mechanical Engineering, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Grafting, 0104 chemical sciences, Natural polymer, chemistry, Mechanics of Materials, Click chemistry, Surface modification, 0210 nano-technology, business, Antibacterial activity, Visible spectrum
Abstract

International audience; A new antibacterial material has been elaborated by grafting mesoarylporphyrin on cotton fabric by the means of cellulose azidation followed by "Click-Chemistry" reaction with acetylenic porphyrin. Azidation and functionalization have been checked by ATR-FTIR spectroscopy. Under irradiation with visible light, this material displayed an antibacterial activity against representative strains of Escherichia coli and Staphylococcus aureus. This new photobactericidal textile has potential for industrial, medical, and household applications.

Published
2009
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