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2. Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study

Author

Ferrante, Marc, D'Haens, Geert, Jairath, Vipul, Danese, Silvio, Chen, Minhu, Ghosh, Subrata, Hisamatsu, Tadakazu, Kierkus, Jaroslaw, Siegmund, Britta, Bragg, Sonja Michelle, Crandall, Wallace, Durand, Frederick, Hon, Emily, Lin, Zhantao, Lopes, Michelle Ugolini, Morris, Nathan, Protic, Marijana, Carlier, Hilde, Sands, Bruce E, Tron, Emiliano, Dorado, Fernanda Dorado, Thin, Lena, Leong, Rupert, Seltenreich, Hans, Christensen, Britt, Croft, Anthony, Ghaly, Simon, Koch, Robert, Reinisch, Walter, Heeren, Sonja, Bossuyt, Peter, Ferrante, Marc, Maximiano, Fabio Luiz, Sassaki, Ligia Yukie, Baia, Carolina, Poli, Debora, de Sousa Carlos, Alexandre, de Magalhaes Francesconi, Carlos Fernando, De Sa Rolim, Alexander, Razera, Julio, Simoes Neto, Joaquim, Rocco, Rodrigo, Stifft, Jonathas, Soldera, Jonathan, Silva, Genoile, Mendes Clemente, Cintia, Di Felice Boratto, Sandra, Teixeira de Campos, Luciana, Rodrigues Borba, Marcelo, Rosenfeld, Gregory, Ponich, Terry, Lim, Allen, Williams, Chadwick, Musgrave, Bruce, Gauthier, Stephane, Liu, Wenjia, Wang, Chengdang, Guo, Hong, Chen, Chunxiao, Chen, Yan Chen, Cao, Qian, Zhong, Jie, Xu, Min, Wang, Yufang, Zheng, Changqing, Gao, Xiang, Chen, Youxiang, Miao, Yinglei, Wang, Lin, Liu, Deliang, Wang, Bangmao, Song, Zhengji, Liu, Xiaowei, Chen, Baili, Jiang, Yi, Zhan, Qiang, Zhang, Kaiguang, Shen, Hong, Li, Zhaotao, Wang, Xiaoyan, Wang, Mei Wang, Tian, De'an, Chen, Lei, Tang, Wen, Borzan, Vladimir, Krznaric, Zeljko, Volfova, Miroslava, Pumprla, Jiri, Veberova, Lucie, Tichy, Michal, Gregar, Jan, Stepek, David, Ulbrych, Jan, Drastich, Pavel, Papik, Zdenek, Matous, Jan, Lukas, Martin, Koskova, Radka, Fallingborg, Jan, Altwegg, Romain, Fotsing, Ginette, Laharie, David, Nancey, Stephane, Peyrin, Laurent, Schreiber, Stefan, Hoffmann, Jörg, Seidler, Ursula, Fechner, Lars, Arelin, Katrin, Contzen, Christel, Trenn, Guido, Schaum, Thomas, Schoettker, Katrin, Bachmann, Oliver, Encke, Jens, Ibe, Michael, Jakobeit, Christian, Varga, Marta, Salamon, Agnes, Kafony, Andras, Horvat, Gyula, Heringh, Zsanett, Bezzegh, Katalin, Izbeki, Ferenc, Szalai, Laszlo, Schnabel, Robert, Samanta, Jayanta, Banerjee, Rupa, Subramanian, Ganesh, Mukewar, Shrikant, Bansal, Naresh Kumar, Sood, Ajit, Shankar Bagepally, Ravi, Kumar, Porika Shravan, Shrimal, Pankaj, Shah, Saumin, Pai, Nitin, Ahuja, Vineet, Melzer, Ehud, Assy, Nimer, Goldin, Eran, Shirin, Haim, Segal, Arik, Lahat, Adi, Saibeni, Simone, Luzza, Francesco, Danese, Silvio, Caprioli, Flavio, Annunziata, Maria Laura, Fantini, Massimo, Matsuda, Koichiro, Takagi, Sho, Kanmura, Shuji, Goto, Mitsuhide, Ashida, Toshifumi, Nishimata, Nobuaki, Kawakami, Kazuhiko, Ishiguro, Yoh Ishiguro, Maemoto, Atsuo Maemoto, Naito, Yuji Naito, Naoe, Hideaki, Nakase, Hiroshi, Iida, Tomohiro, Akiyama, Junichi, Yoshioka, Masao, Abe, Yasuhiko, Takeuchi, Ken, Kawai, Mikio, Hirai, Fumihito, Horiki, Noriyuki, Park, Sang Hyoung, Park, Dong II, Kang, Sang Bum, Jung, Min Kyu, Jang, Byung Ik, Lee, Yoo Jin, Shin, SungJae, Kim, Tae-oh, Kim, Hyun-Soo, Lee, Bo-In, Lee, Jonghun, Kim, Hyo Jong, Choi, Chang Hwan, Kim, Dongwoo, Eun, Chang Soo, Kang, Ben, Pokrotnieks, Juris, Kiudelis, Gediminas, Ramirez, Karina, Vega Fonseca, Jose Luis, Laheij, Robert, Kierkus, Jaroslaw, Klopocka, Maria, Wylegala, Zbigniew, Mroziak, Beata, Wojcik, Katarzyna, Korczowski, Bartosz, Gawdis, Beata, Danilkiewicz, Wit, Olszanecka, Magdalena, Krzykowska, Jolanta, Jamrozik, Zofia, Duszynska, Malgorzata, Ciesiolkiewicz, Agnieszka, Baluta, Malgorzata, Horynski, Marek, Leszczyszyn, Jaroslaw, Rozumek, Grzegorz, Firkowski, Lukasz, Konopko, Marzena, Orleanski, Jakub, Filip, Rafal, Wiechowska, Anna, Niezgoda, Krzysztof, Mateescu, Radu, Craciun, Eugeniu, Chioncel, Camelia, Musat, Marioara, Voiosu, Theodor Alexandru, Trofimov, Vasily, Shchukina, Oksana, Pershko, Anatoly, Fedorishina, Olga, Chumakova, Galina, Bakulin, Igor, Osipenko, Marina, Nikolin, Denis, Barysheva, Olga, Alexeeva, Olga, Zakharov, Konstantin, Khodareva, Irina, Tkachev, Alexander, Golovenko, Alexey, Popova, Veronika, Kashnikov, Vladimir, Vershinina, Maria, Makarchuk, Pavel, Valuyskikh, Ekaterina, Crevar, Slobodanka, Svorcan, Petar, Radakovic, Tatjana, Hlavaty, Tibor, Bunganic, Ivan, Fedurco, Miroslav, Kalisova, Iveta, Balaz, Jozef, Mihalkanin, Lubomir, Martin Arranz, Maria Dolores, De Teresa Parreno, Luis, Sans Cuffi, Miquel, Hernandez Camba, Alejandro, Brand, Stephan, Juillerat, Pascal, Seibold, Frank, Demirci, Hakan, Tezel, Ahmet, Simsek, Halis, Kiyici, Murat, Gonen, Can, Hulagu, Sadettin, Karakan, Tarkan, Cekin, Ayhan, Altintas, Engin, Guven, Kadri, Akpinar, Hale, Ozin, Yasemin, Erzin, Yusuf, Demir, Mehmet, Temel, Tuncer, Lohdanidi, Tetiana, Ivanov, Valeriy, Ivanishyn, Olha, Golovchenko, Oleksandr, Gerasymenko, Oksana, Danyliuk, Svitlana, Vyshyvanyuk, Vira, Datsenko, Olena, Stanislavchuk, Mykola, Rishko, Yaroslava, Kyrychenko, Olga, Donets, Dmytro, Shapovalova, Yana, Yurkiv, Andriy, Oliinyk, Oleksandr, Tsarynna, Nataliia, Fediv, Oleksandr, Poplyonkin, Yevgen, Kaser, Arthur, Hoque, Syed, Thomas, Hawys, Iyengar, Shalini, Newman, Frederic, Fogel, Ronald, Pedersen, Peder, Gonzales, Chad, McCord, Gregory, Galambos, Michael, Lamb, Paul, Schneider, Jeffrey, Bhandari, Bal Raj, Weiss, Michael, Thai, Christine, Shapiro, Michael, Younes, Ziad, Murali, Narayanachar, Hou, Jason, Williams, Todd, Khalid, Omer, Hsu, Connie, Bartalos, Christopher, Arimie, Calin, Mumtaz, Syed, Crespo, Israel, Marchioni Beery, Renee, Tuskey, Anne, Gaible, Ryan, Cutler, Alan, Afzali, Anita, Stuart, Kevin, Ibegbu, Eric, Irizarry-Roman, Moises, Harris, Kimberly, Agyei, Kwadwo, Jones, Frances, Sheikh, Aasim, Zakko, Liam, Cohen, Erica, Duvall, George, Al Kharrat, Houssam, Wohlman, Robert, Holderman, William, Schulman, Alan, Lidofsky, Sheldon, Wayne, Peter, Victores, Luis, Stone, Christian, Onwueme, Kenolisa, Fischer, Monika, Shahid, Shabana, Moore, Keith, Katz, Jeffry, Bullock, Jeff, and Fahed, Julien

Abstract

Mirikizumab, a humanised monoclonal antibody that inhibits IL-23p19, is effective in moderate-to-severe ulcerative colitis. We aimed to evaluate the efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease.

Published
2024
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17. Carbon dioxide complexation: infrared spectroscopy of iron and ruthenium eta-5-cyclopentadienyl carbonyl metallocarboxylates

Author

Pinkes, John R., Masi, Christopher J., Chiulli, Robert, Steffey, Bryan D., and Cutler, Alan R.

Subjects
Organometallic compounds -- Research, Complex compounds -- Research, Ruthenium -- Analysis, Cyclopentadiene -- Analysis, Chemistry
Abstract

The reaction of CpM(CO)(sub2)(super -) -Li+, -Na+, -K+ or -Mg2+ metalate with carbon dioxide at -78 degrees celsius yields iron and ruthenium eta-5-cyclapentadienyl carbonyl metallocarboxylates. FpCO(sub 2)(super -)-Mg2+, -Li+, -Na+ and -K+ are stable at room temperature. Their infrared spectra is consistent with the ionic metallocarboxylate structures that have symmetric chelation with metallic counterion. The reversible dissociation of CO2 from the metallocarboxylates converts the unbound 13CO2 to unlabelled CO2.

Published
1997

20. Hydrosilation of the manganese acetyl (CO)5MnC(O)CH3 with monohydrosilanes

Author

Gregg, Brian T. and Cutler, Alan R.

Subjects
Silane -- Analysis, Catalysis -- Research, Manganese -- Analysis, Chemistry
Abstract

The hydrosilation chemistry between the manganese acetyl (CO)5MnC(O)CH3 and 13 monohydrosilanes is described. Two noteworthy findings are the isolable alpha-siloxyethyl complexes (CO)5MnCH(OSiR3)CH3 afforded by reactions between (CO)5MnC(O)CH3 and monohydrosilanes and the fact that these reactions generate an alpha-siloxyvinyl byproduct (CO)5MnC(OSiR3)=CH2. Hydrosilation of the isolobal iron acetyl compounds Cp(CO)(L)FeC(O)CH3 yields Cp(CO)(L)FeCH(OSiR3)CH3, requiring a catalyst, while hydrosilation of the cobalt acetyl compounds (PR3)(CO)3CoC(O)CH3 generates equimolar mixtures of (CO)3(PR3)CoSiR3 plus CH3CH2OSiR3, without a catalyst.

Published
1996

21. Notes from the underground

Author

Cutler, Alan

Subjects
Signal processing -- Usage -- Research, Paleontology -- Research -- Usage, Fossils -- Research -- Usage, Science and technology, Digital signal processor, Usage, Research
Abstract

Time the destroyer is time the preserver --T. S. Eliot, 'The Dry Salvages' FOR ONE OF THE GREAT LANDMARKS OF THE history of our planet, the scrubby Wyoming hillside was [...]

Published
1995

23. Iron-tin carbon dioxide complexes (eta5-C5Me5)(CO)2Fe-CO2SnR3 (R = Me, Ph): observations pertaining to unsymmetrical metallocarboxylates and carboxylate-carbonyl 13C-label exchange

Author

Pinkes, John R. and Cutler, Alan R.

Subjects
Coordination compounds -- Research, Carbon dioxide -- Analysis, Chemistry
Abstract

Cp(CO)2Fe-SnR3 is synthesized by the treatment of R3SnCl with Cp(CO)2Fe-CO2 in THF at a temperature of -78 degrees centigrade. The synthesis is attributed to the dissociation of the metallocarboxylates to Cp(CO)2Fe-Kt. Ph3SnCl, a thermally stable iron-tin carboxylate, traps the more nucleophilic Cp(CO)2Fe-CO2-K+. Other trapping experiments yield similar but different compounds of Cp(CO)2Fe.

Published
1994

25. Diagnosing and managing H. pylori infections

Author

Cutler, Alan F.

Subjects
Helicobacter infections -- Diagnosis
Abstract

Helicobacter pylori infection has been strongly associated with gastritis, duodenal ulcers, gastric ulcers, gastric adenocarcinoma and gastric lymphoma. The diagnosis of H. pylori infection has been grouped into two major categories: noninvasive/nonendoscopic and invasive/endoscopic. The first group includes fecal antigen test, antibody detection and urea breath test, while the second group includes rapid urease tests, histology and culture., Helicobacter pylori is the most common bacterial infection found in man. The bacterium appears as a spiral or curved, motile, gram-negative rod (1.5-10 [[micro]meter] in length) that is strongly urease [...]

Published
1999

28. Testing for helicobacter pylori in clinical practice

Author

Cutler, Alan F.

Subjects
Helicobacter infections -- Diagnosis, Health, Health care industry
Abstract

It is now accepted that cure of Helicobacter pylori infection will result in healing of chronic active gastritis and will change the natural history of gastroduodenal ulcer disease. A variety of highly sensitive and specific diagnostic methods have been developed over the past few years to establish whether a patient is infected with this organism. The two major categories of diagnostic tests for H. pylori are invasive methods, which require endoscopy, and noninvasive tests in which endoscopy is not necessary. Invasive tests include rapid urease tests, histology, and culture. Noninvasive tests include various methods of antibody detection and carbon-labeled urea breath tests. This review describes the characteristics, appropriate uses, and comparative accuracy of the available diagnostic tests for detection of H. pylori. It offers suggestions on the test of choice to establish a patient's H. pylori infection status in different clinical settings.

Published
1996

35. Four-year trends in Helicbacter pylori IgG serology following successful eradication

Author

Cutler, Alan F., Prasad, Vajravel M., and Santogade, Peter

Subjects
Helicobacter infections -- Diagnosis, Immunoglobulin G, Helicobacter pylori, Health, Health care industry
Abstract

PURPOSE: Detection of anti-Helicobacter priori antibodies is accurate in the diagnosis of the infection, and there is a decline in IgG titers after successful eradication. It is not known whether these titers continue to decline during the next 3 to 4 years. PATIENTS AND METHODS: Patients had been successfully treated for H pylori with triple therapy (metronidazole, tetracycline, and bismuth subsalicylate) during 1990 and 1991. Those who had frozen serum samples available from that time were contacted to have follow-up serum collected in 1994. A simultaneous [[sup.13]C]urea breath test was done to confirm H pylori infection status. Serology was determined by quantitative enzyme-linked immunosorbent assay (ELISA) and qualitative immunoassay. RESULTS: All 29 patients who agreed to participate were free of H pylori infection. They had a mean decrease in H pylori IgG titers of 51% from baseline (P [is less than] 0.001). Titers remained stable from 1 year to a mean of 3.5 years after therapy (range 2.8 to 4.4). Of the 29 patients, 21 (72%) remained seropositive by ELISA 3.5 years after successful H priori treatment, and 18 (62%) remained positive by rapid serum immunoassay. CONCLUSION: IgG titers against H priori plateau at a 50% decrease after therapy. Helicobacterpylori serology, either quantitative or qualitative, will yield false positive results in patients who have previously been treated for H pylori and should not be used to determine infection status in this population. Am J Med. 1998;105:18-20. [C] 1998 by Excerpta Medica, Inc.

Published
1998

40. Consumer Education: The Key to Successful Plastics Recycling.

Author

Cutler, Alan and Moore, Susan

Abstract

Examines consumer education strategies for decreasing contamination in plastics collected for recycling. Discusses research that suggests the problem may not be consumers ignoring rules but rather that consumers appear to be adhering diligently to rules of their own invention. (LZ)

Published
1995

41. lonely at the top

Author

Cutler, Alan

Subjects
Mentors -- Services, Leadership -- Vocational guidance, Business, Business, international, Travel industry
Abstract

Managing a team is all about providing good leadership and support, but what happens when the leader needs guidance? Alan Cutler explains how mentors are proving invaluable within independent and [...]

Published
2005

42. Biologically Active Natural Products

Author

HORACE G. CUTLER, Horace G. Cutler, Alan R. Lax, Hurley S. Shepherd, Judson V. Edwards, Oliver D. Dailey, John M. Bland, Horace G. Cutler, S. Sakamura, A. Ichihara, T. Yoshihara, R. M. Heisey, S. K. Mishra, A. R. Putnam, J. R. Miller, C. J. Whitenack, J. E. Keller, J. Huang, Horace G. Cutler, Eberha

Published
1988

44. 200 years of accommodation

Author

Cutler, Alan

Subjects
Before Darwin: Reconciling God and Nature (Book) -- Thomson, Keith Stewart, Before Darwin: Reconciling God and Nature (Nonfiction work) -- Book reviews, Books -- Book reviews, Science and technology
Abstract

Before Darwin Reconciling God and Nature Keith Thomson Yale University Press, New Haven, CT, 2005. 328 pp. $27. ISBN 0-300-10793-5. The Watch on the Heath Science and Religion Before Darwin [...]

Published
2005

46. Re2Rh2mu3-[eta1-C(Re):eta1-O(Rh):eta1-O'(Rh')] bis(carbon dioxide) complexes [(eta5-C5R5)(L)(NO)Re(CO2)Rh(eta4-diene)]2 that are structurally related to rhodium(I) carboxylate dimers [Rh(O2CR)(eta4-diene)]2

Author

Tetrick, Stephen M., Tham, Fook S., and Cutler, Alan R.

Subjects
Complex compounds -- Research, Transition metal compounds -- Research, Chemistry
Abstract

A study examined five heterobimetallic Re2Rh2-(mu3-CO2)2 complexes, [(eta5-C5R5)(L)(NO)Re(CO2)Rh(eta4-diene)]2. They were found to feature two mu3-[eta1-C(Re):eta1-O(Rh):eta1-O'(Rh')] carboxylate ligands and structurally appear like the catalytically active Rh(I) carboxylates, [(RCO2)Rh(diene)]2. An X-ray structure determination revealed the Re2Rh2(eta3-CO2)2 core of the complex as two square-planar Rh centers, each featuring a chelating COD ligand and one oxygen atom from each mu-(eta1-O:eta-O').

Published
1997

47. Catalytic hydrosilation of organic esters using manganese carbonyl acetyl complexes, (L)(CO)4MnC(O)CH3 (L = CO, PPh3)

Author

Mao, Zhibiao, Gregg, Brian T., and Cutler, Alan R.

Subjects
Esters -- Research, Catalysts -- Usage, Chemical reactions -- Observations, Chemistry
Abstract

The hydrosilation of organic esters are catalyzed by manganese acetyl complexes (L)(CO)4MnC(O)CH3 (L = PPh3, 1; CO, 2) consecutively leading to silyl acetal RCH(OSiR'3)OR', ether RCH2OR' or alkoxysilane products RCH2OSiR'3 and R'OSiR'3. The coordinatively unsaturated manganese silyl is the active catalyst (L)(CO)3MnSiR3 initially formed by transformation of the precatalyst 1 or 2.

Published
1995

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