34 results on '"Cupples, Rod"'
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2. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors
3. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
4. Structural Characterization and Pharmacodynamic Effects of an Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor
5. GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF
6. Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ*S–X) Interaction for Conformational Constraint
7. Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis
8. Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors
9. Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 4. Exploration of a Novel Binding Pocket
10. Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N′-arylpiperazine Series
11. Correction to Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept
12. Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept
13. Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles
14. Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)
15. The discovery of 2-anilinothiazolones as 11β-HSD1 inhibitors
16. Further Studies with the 2-Amino-1,3-thiazol-4(5H)-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and Exploring Activity in a Monkey Pharmacodynamic Model
17. Structural Characterization and Pharmacodynamic Effects of an Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor
18. 2-(S)-Phenethylaminothiazolones as Potent, Orally Efficacious Inhibitors of 11β-Hydroxysteriod Dehydrogenase Type 1
19. Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → s*S-X) Interaction for Conformational...
20. Small Molecule Disruptors of the Glucokinase–GlucokinaseRegulatory Protein Interaction: 4. Exploration of a Novel BindingPocket.
21. Small Molecule Disruptorsof the Glucokinase–GlucokinaseRegulatory Protein Interaction: 3. Structure–Activity Relationshipswithin the Aryl Carbinol Region of the N-Arylsulfonamido-N′-arylpiperazine Series.
22. Cloning and Characterization of a Specific Receptor for Mouse Oncostatin M
23. GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
24. Small Molecule Disruptorsof the Glucokinase–GlucokinaseRegulatory Protein Interaction: 2. Leveraging Structure-Based DrugDesign to Identify Analogues with Improved Pharmacokinetic Profiles.
25. Small Molecule Disruptorsof the Glucokinase–GlucokinaseRegulatory Protein Interaction: 1. Discovery of a Novel Tool Compoundfor in Vivo Proof-of-Concept.
26. Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family
27. Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit
28. Human α2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene
29. Primary structure and functional expression of rat and human stem cell factor DNAs
30. Evolutionary and structural relationships among the group-specific component, albumin and α-fetoprotein.
31. Correction to Small MoleculeDisruptors of the Glucokinase–Glucokinase Regulatory ProteinInteraction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept.
32. Evolutionary and structural relationships among the group-specific component, albumin and {alpha}-fetoprotein
33. Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → s*S-X) Interaction for Conformational Constraint
34. 2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1.
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