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4. NF-M is an essential target for the myelin-directed “outside-in” signaling cascade that mediates radial axonal growth

Author

Garcia, Michael L, Lobsiger, Christian S, Shah, Sameer B, Deerinck, Tom J, Crum, John, Young, Darren, Ward, Christopher M, Crawford, Thomas O, Gotow, Takahiro, Uchiyama, Yasuo, Ellisman, Mark H, Calcutt, Nigel A, and Cleveland, Don W

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Neurological, Action Potentials, Amino Acid Motifs, Animals, Axons, Mice, Mice, Transgenic, Models, Biological, Motor Activity, Myelin Sheath, Nerve Fibers, Myelinated, Neurofilament Proteins, Phosphorylation, Protein Structure, Tertiary, Protein Subunits, Signal Transduction, myelin, neurofilaments, phosphorylation, axon caliber, radial growth, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Neurofilaments are essential for acquisition of normal axonal calibers. Several lines of evidence have suggested that neurofilament-dependent structuring of axoplasm arises through an "outside-in" signaling cascade originating from myelinating cells. Implicated as targets in this cascade are the highly phosphorylated KSP domains of neurofilament subunits NF-H and NF-M. These are nearly stoichiometrically phosphorylated in myelinated internodes where radial axonal growth takes place, but not in the smaller, unmyelinated nodes. Gene replacement has now been used to produce mice expressing normal levels of the three neurofilament subunits, but which are deleted in the known phosphorylation sites within either NF-M or within both NF-M and NF-H. This has revealed that the tail domain of NF-M, with seven KSP motifs, is an essential target for the myelination-dependent outside-in signaling cascade that determines axonal caliber and conduction velocity of motor axons.

Published
2003

5. Complete Genome Sequences of Chop, DelRio, and GrandSlam, Three Gordonia Phages Isolated from Soil in Central Arkansas

Author

Mathes, Heidi N., primary, Christenson, Elijah I., additional, Crum, John H., additional, Edmondson, Emme M., additional, Gray, Kassidy E., additional, Lawson, Luke W., additional, Lee, Lauren E., additional, Lee, Michael P., additional, Lipscomb, Jackson A., additional, Masengale, Morgan E., additional, Matthews, Hannah G., additional, McClain, Charles M., additional, Melton, Tuesday N., additional, Morrow, Trace H., additional, Perry, Alexis M., additional, Rainwater, David R., additional, Renois, Grace E., additional, Rettig, Maryann F., additional, Troup, Duncan C., additional, Wilson, Allie J., additional, Reyna, Nathan S., additional, and Plymale, Ruth, additional

Published
2023
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7. Marijuana Liberalization and Alcohol Consumption

Author

Crum, John and Galvin, Miranda

Subjects
Sociology, medical marijuana, recreational marijuana, binge drinking, alcohol use, alcohol-related harms, mental disorders, Medicine and Health Sciences, FOS: Law, Public Health, Public Affairs, Public Policy and Public Administration, Social and Behavioral Sciences, Health Law and Policy, Law, FOS: Sociology
Abstract

This project aims to explore the relationship between state marijuana liberalization policies (decriminalization, medical marijuana, and recreational marijuana) and alcohol consumption and alcohol-related harms.

Published
2022
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11. Continuity amid discontinuity? George W. Bush, federal employment discrimination, and 'big government conservatism'

Author

Bradbury, Mark D., Battaglio, R. Paul, Jr., and Crum, John L.

Subjects
Public employees -- Human resource management, Employment discrimination -- Analysis, Civil service reform -- Analysis, Merit pay, Company personnel management, Government, Human resources and labor relations, Political science
Abstract

A study analyzes whether the Bush administration policy of 'big government conservatism' which was predisposed against public employee unions, supportive of managerial discretion but still maintaining equal workplace opportunity was successful. Findings reveal that perceptions of retaliation and discrimination are found to have decreased presently, although still existing among minority and female employees and managers in federal workplaces requiring vigilance.

Published
2010

15. Training in times of limited resources

Author

Crum, John L.

Subjects
Employee training -- Evaluation, Administrative agencies -- Reorganization, Public employees -- Training, Government
Abstract

Lack of management support for training of public employees can be traced to the failure of the personnel department to show management that the money spent on such programs has been wisely spent. Training is a crucial factor to the successful transformation of administrative programs. Governments need to train employees on technological change and organizational management so that they can provide the general public with the best possible service., In many cases, the lack of support for training can be tied to a failure to show management that the money devoted to training in the past has been wisely [...]

Published
1995

16. Working for America: does public service motivation make a difference?

Author

Naff, Katherine C. and Crum, John

Subjects
Public service employment -- Psychological aspects, Public employees -- Beliefs, opinions and attitudes, Job satisfaction -- Surveys, Government, Human resources and labor relations, Political science
Abstract

The authors surveyed 10,000 federal employees as part of the research attempting to determine whether motivational differences exist between private and public employees. The research resulted in significant associations between public employment and factors such as job satisfaction and career plans.

Published
1999

17. Getting back to basics with equipment acquisition

Author

Crum, John

Subjects
Construction equipment -- Purchasing, Contractors -- Purchasing, Construction and materials industries
Abstract

Now that there are signs of life in the U.S. economy, more contractors are coming out of hibernation and starting to look for equipment to buy. Before you decide to [...]

Published
2010

18. Building a quality federal work force

Author

Crum, John L.

Subjects
United States. Office of Personnel Management -- Recruiting, College graduates -- Employment, Employee recruitment -- Methods, Public employees -- Appointments, resignations and dismissals, Business, Business, general, Government
Published
1990

23. Fixing federal hiring

Author

Crum, John

Subjects
United States. Government Accountability Office -- Reports -- Laws, regulations and rules, Employee selection -- Laws, regulations and rules -- Reports, Federalism -- Laws, regulations and rules -- Reports, Government, Government regulation, Hiring, Reports, Laws, regulations and rules
Abstract

In a May 2004 report, the U.S. General Accountability Office (GAO) identified a number of barriers to efficient and effective hiring in the federal government (http://www.gao.gov/highlights/d04959thigh.pdf). This report concluded what [...]

Published
2004

24. After the fall: making the new federal personnel changes work

Author

Crum, John

Subjects
United States. Department of Defense -- Human resource management -- Laws, regulations and rules, United States. Department of Homeland Security -- Laws, regulations and rules -- Human resource management, Public employees -- Compensation and benefits -- Laws, regulations and rules, Government, Government regulation, Company personnel management, Human resource management, Compensation and benefits, Laws, regulations and rules
Abstract

The landscape for federal personnel management is changing dramatically. With the publication of proposed regulations for the US Department of Homeland Security (DHS) in February and recent legislation which allows [...]

Published
2004

25. Should the federal government be viewed as one employer or many employers?

Author

Crum, John

Subjects
Administrative agencies -- Human resource management -- Officials and employees, Public employees -- Recruiting, Government, Industry hiring, Company personnel management, Human resource management, Officials and employees, Recruiting
Abstract

Over the past two decades the federal government has changed dramatically both its recruitment and selection processes. For example, until the early 1980s, the government did most of its hiring [...]

Published
2003

26. Pay for performance: the answer to the human capital crisis?

Author

Crum, John

Subjects
United States -- Social policy, Administrative agencies -- Human resource management, Government executives -- Compensation and benefits, Government, Company personnel management, Human resource management, Social policy, Compensation and benefits
Abstract

The stars may be aligning themselves to move the federal government to a new method for determining increases in employee compensation. With the creation of the US Department of Homeland [...]

Published
2003

35. Book Review: Auto Mechanics: Technology and Expertise in Twentieth Century America, De trage verbreiding van de auto in Nederland, 1896–1939, The Chequered Past: Sports Car Racing and Rallying in Canada, 1951–1991, Iron Horse Imperialism: The Southern Pacific of Mexico, 1880–1951, Trainland: How Railways made New Zealand, The Norfolk Railway: Railway Mania in East Anglia, 1834–1862, Historia de los ferrocarriles de vía estrecha en España, Historia de los poblados ferroviarios en España, Compañía de Tranvías de la Coruña (1876–2005): Redes de transporte local, Mot framtiden på gamla spår? Regionala intressegrupper och beslutsprocesser kring kustjärnvägarna i Norrland under 1900—talet, Die Einbeziehung Stuttgarts in das moderne Verkehrswesen durch den Bau der Eisenbahn. Entscheidungsprozesse, Standortpolitik, ökonomische Voraussetzungen, Funktionalität und Resultate der verkehrlichen Erschließung zwischen 1830 und 1930, Informationen zur modernen Stadtgeschichte, Unterwegs und mobil. Verkehrswelten im Museum, Handbuch Verkehrspolitik, Verkehrsgeschichte auf neuen Wegen [Transport infrastructure and politics], Jahrbuch für Wirtschaftsgeschichte 2007/1 [Economic History Yearbook 2007/1], a Mobile Century? Changes in Everyday Mobility in Britain in the Twentieth Century, Die Überwindung der Distanz. Zeit und Raum in der europäischen Moderne [Overcoming distance: Time and space in Europe's Modern Age], Das öffentliche Bild vom öffentlichen Verkehr. Eine sozialwissenschaftlich-Hermeneutische Untersuchung von Printmedien [The Public View on Public Transport: Hermeneutical Social Science Studies of the Print Media], Transport Design: A Travel History, The Business of Tourism: Place, Faith, and History, Dziedzictwo morskie i rzeczne polski [Poland's Maritime Heritage]

Author

Crum, John, primary, Weber, Donald, additional, Guise-Richardson, Cai, additional, Schwantes, Carlos, additional, Carter, Ian, additional, Wakeford, Tony, additional, Mata, Maria Eugénia, additional, Olivares, Javier Vidal, additional, Marco, José Luis Hernández, additional, Ottosson, Jan, additional, Roth, Ralf, additional, Elsasser, Kilian T., additional, Wydler, Henry, additional, Vahrenkamp, Richard, additional, Dinhobl, Günter, additional, Higginson, Martin, additional, Roskothen, Johannes, additional, Schmidt, Gert, additional, Lyth, Peter, additional, Gordon, Bertram M., additional, and Hartwich, Mateusz J., additional

Published
2008
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36. The combination of chemical fixation procedures with high pressure freezing and freeze substitution preserves highly labile tissue ultrastructure for electron tomography applications

Author

Sosinsky, Gina E., primary, Crum, John, additional, Jones, Ying Z., additional, Lanman, Jason, additional, Smarr, Benjamin, additional, Terada, Masako, additional, Martone, Maryann E., additional, Deerinck, Thomas J., additional, Johnson, John E., additional, and Ellisman, Mark H., additional

Published
2008
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45. Fission and Uncoating of Synaptic Clathrin-Coated Vesicles Are Perturbed by Disruption of Interactions with the SH3 Domain of Endophilin

Author

Gad, Helge, primary, Ringstad, Niels, additional, Löw, Peter, additional, Kjaerulff, Ole, additional, Gustafsson, Jenny, additional, Wenk, Markus, additional, Di Paolo, Gilbert, additional, Nemoto, Yasuo, additional, Crum, John, additional, Ellisman, Mark H., additional, De Camilli, Pietro, additional, Shupliakov, Oleg, additional, and Brodin, Lennart, additional

Published
2000
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50. A Question of Equity: Women and the Glass Ceiling in the Federal Government

Author

MERIT SYSTEMS PROTECTION BOARD WASHINGTON DC OFFICE OF POLICY AND EVALUATION, Naff, Katherine C., Crum, John, MERIT SYSTEMS PROTECTION BOARD WASHINGTON DC OFFICE OF POLICY AND EVALUATION, Naff, Katherine C., and Crum, John

Abstract

This study was conducted by the U.S. Merit Systems Protection Board to find out whether women in Federal Government service face subtle barriers to career advancement, also known as the "glass ceiling." The Board found that women do confront inequitable barriers to advancement in their Federal careers. These barriers take the form of subtle assumptions, attitudes, and stereotypes that affect how managers may view women's potential for advancement and, in some cases, their effectiveness on the job. Furthermore, the Board found that women face obstacles to advancement not only at the GS/GM 13 level and above but also at lower levels in the pipeline. In addition, it appears that minority women face a double disadvantage because of their gender and their race or national origin.

Published
1992

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