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1. Plasma and tumor genomic correlates of response to BYL719 in PI3KCA mutated metastatic ER-positive breast cancer (ER+/HER2- BC)

Author

Peter Savas, Maria Joao Silva, Keilly Kuykhoven, Courtney VanGeelen, Miriam M. Yeung, Sarah-Jane Dawson, Prudence A. Francis, Stephen J Luen, Rodney J. Hicks, Chen-Fang Weng, Andjelija Zivanovic Bujak, Sarah Ftouni, Lironne Wein, Sherene Loi, Kate Moodie, and Chee Khoon Lee

Subjects
Cancer Research, business.industry, Estrogen receptor, Phases of clinical research, 030226 pharmacology & pharmacy, Hedgehog signaling pathway, 03 medical and health sciences, 0302 clinical medicine, Oncology, Cancer research, Medicine, 030212 general & internal medicine, business, Gene, PI3K/AKT/mTOR pathway
Abstract

1055Background: Mutations of genes involved in the PI3K signalling pathway occur frequently in BC. We performed a phase II study of BYL719, a selective PI3Kα inhibitor, in BC to evaluate its effica...

Published
2018
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