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Plasma and tumor genomic correlates of response to BYL719 in PI3KCA mutated metastatic ER-positive breast cancer (ER+/HER2- BC)
- Source :
- Journal of Clinical Oncology. 36:1055-1055
- Publication Year :
- 2018
- Publisher :
- American Society of Clinical Oncology (ASCO), 2018.
-
Abstract
- 1055Background: Mutations of genes involved in the PI3K signalling pathway occur frequently in BC. We performed a phase II study of BYL719, a selective PI3Kα inhibitor, in BC to evaluate its effica...
- Subjects :
- Cancer Research
business.industry
Estrogen receptor
Phases of clinical research
030226 pharmacology & pharmacy
Hedgehog signaling pathway
03 medical and health sciences
0302 clinical medicine
Oncology
Cancer research
Medicine
030212 general & internal medicine
business
Gene
PI3K/AKT/mTOR pathway
Subjects
Details
- ISSN :
- 15277755 and 0732183X
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Oncology
- Accession number :
- edsair.doi...........7c22e01cc7ad8ac7cc2181bf71995424
- Full Text :
- https://doi.org/10.1200/jco.2018.36.15_suppl.1055