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1. Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials

Author

Martins, Marcelo D, Cahn, Pedro E, Lopardo, Gustavo D, Porteiro, Norma, Bloch, Mark Theo, Baker, David Alfred, Roth, Norman, Moore, Richard J, Finlayson, Robert James, McMahon, James, Rieger, Armin, Zoufaly, Alexander, Schmied, Brigitte, Hartl, Sylvia, Zangerle, Robert, Smaill, Fiona, Walmsley, Sharon L, Conway, Brian, Rachlis, Anita, Smith, Graham H R, Perez Cortes, Carlos, Afani, Alejandro, Campos Barker, Maria Isabel E, Chahin Anania, Carolina Eugenia, Reyes, Marcelo J. Wolff, Gerstoft, Jan, Weis, Nina, Laursen, Alex Lund, Molina, Jean-Michel, Yazdanpanah, Yazdan, Cotte, Laurent, Raffi, Francois, Slama, Laurence, Morlat, Philippe, Girard, Pierre-Marie, Katlama, Christine, Rockstroh, Juergen K, Arasteh, Keikawus, Esser, Stefan, Stoehr, Albrecht, Stellbrink, Hans-Juergen, Stoll, Matthias, Schuermann, Dirk, Faetkenheuer, Gerd, Bogner, Johannes Richard, Lutz, Thomas, Baumgarten, Axel, Jaeger, Hans, Wiese, Carmen, Gori, Andrea, Migliorino, Guglielmo Marco, Coltan, Gabriel, Constandis, Felicia, Erscoiu, Simona M, Prisacariu, Liviu-Jany, Rugina, Sorin, Streinu-Cercel, Adrian, Pokrovsky, Vadim V, Zakharova, Natalia, Shuldyakov, Andrey Anatolyevich, Ryamova, Elena Pavlovna, Kulagin, Valeriy Viktorovich, Tsybakova, Olga Aleksandrovna, Orlova-Morozova, Elena, Nagimova, Firaya, Voronin, Evgeniy, Shimonova, Tatiana Evgenyevna, Kozyrev, Oleg Anatolyevich, Orrell, Catherine, Lombaard, Johannes Jurgens, Botes, Margaretha Elizabeth, de Jager, Marleen, Segorb, Joaquin Portilla, Gatell Artigas, Josep Maria, Mallolas Masferrer, Josep, Guillen, Santiago Moreno, Perez Elias, Maria Jesus, Arribas Lopez, Jose R, Puigmal, Eugenia Negredo, Podzamczer Palter, Daniel, Ortega, Frederico Pulido, Garcia, Jesus Troya, de los Santos Gil, Ignacio, Berenguer, Juan, Nelson, Mark Richard, Williams, Ian G, Johnson, Margaret A, Khoo, Saye, Schembri, Gabriel, Clarke, Amanda, Gompels, Mark, Fox, Julie Meriel, Lwanga, Julianne, Taylor, Steven John, Dockrell, David Harold, Kegg, Stephen, Hagins, Debbie P, Osiyemi, Olayemi O, Prelutsky, David James, Ramgopal, Moti N, Scarsella, Anthony J, Dretler, Robin, DeJesus, Edwin, Bettacchi, Christopher J, Sims III, James, Clay, Patrick G, Bellos, Nicholaos C, Thompson, Melanie A, Montero, Jose, McDonald, Cheryl K, Creticos, Catherine, Shamblaw, David, Terrelonge, Antonio E, Valdes, Martin, Tashima, Karen T, Robbins, William J, Elion, Richard A, Goldstein, Deborah, Slim, Jihad, Lalezari, Jacob Paul, Pushkin, Richard, Lalla-Reddy, Sujata N, Win, Sanda S, Ruane, Peter Jerome, Mills, Anthony Martin, Cade, Jerry L, Campo, Rafael, Dietz, Craig A, Hoffman-Terry, Margaret, Blick, Gary, Rubin, David Scott, Mayer, Cynthia, Rondon, Juan Carlos, Cook, Paul P, Daar, Eric, Kumar, Princy N, Swindells, Susan, Castro, Jose Guillermo, Morales-Ramirez, Javier O, Santiago, Lizette, Santana-Bagur, Jorge L, Vandekerckhove, Linos, Florence, Eric, De Wit, Stephane, Derdelinckx, Inge, Vandercam, Bernard, Belkhir, Leila, De Wet, Joseph, Lebouche, Bertrand, Trottier, Benoit, Longpre, Daniele, Szabo, Jason, LeBlanc, Roger P, Jensen, Werner, Gonzalez, Alvaro Rojas, Beltran, Carlos, Sussmann, Otto Alberto, Velez, Juan Diego, Onate, Jose Millan, Nielsen, Henrik, Degen, Olaf, Stephan, Christoph, Arathoon, Eduardo, Lopez, Rudy Manuel, Rojas Alvarado, Evelyn Michelle, Gonzalez Patzan, Luis Demetrio, Meija, Carlos R, Pinzon, Rodolfo, Parchment, Charles, Sthoeger, Zev, Chowers, Michal, Riesenberg, Klaris, Shahar, Eduardo, Levy, Itzchak, Quintero Perez, Nora Patricia, Andrade-Villanueva, Jaime Federico, Crabtree Ramirez, Brenda Eloisa, Rijnders, Bart, den Hollander, Jan G, Handy, Rupert, Morales, Nilo Bonifacio, Hidalgo, Jose Alfredo, Infante, Rosa Mercedes, Matos Prado, Eduardo Demetrio, Campos, Pablo E, Ticona Chaves, Eduardo Romulo, Pinedo, Yvett, Pacheco, Patricia, Maltez, Fernando Manuel, Cunha, Jose, Neves, Isabel, Serrao, Rosario, Melendez-Rivera, Ivan, Mendoza-Rodriguez, Rafael O, Maldonado-Rivera, Sandra, Ortiz-Lasanta, Grisell, Kizhlo, Svetlana, Freud, Hernando Knobel, Moreno, Jose Sanz, Mendez, Francisco Vera, Mohapi, Lerato, Mitha, Essack Aziz, Mahomed, Akbar Anvar, Fouche, Leon Frederik, Kaplan, Richard, Siddique, Naeem, Hoosen, Farzana, Rassool, Mohammed Siddique, Baraldi, Ezio, Calmy, Alexandra, Cavassini, Matthias, Fehr, Jan, Tsai, Hung-Chin, Lin, Hsi-Hsun, Huang, Chun-Kai, Ko, Wen-Chien, Lin, Yu-Hui, Chen, Su-Jung, Hung, Chien-Ching, Avihingsanon, Anchalee, Kiertiburanakul, Sasisopin, Ratanasuwan, Winai, Supparatpinyo, Khuanchai, Chetchotisakd, Ploenchan, Changpradub, Dhitiwat, Orkin, Chloe, Fox, Ashini, Winston, Alan, Ustianowski, Andrew, Yangco, Bienvenido G, Asmuth, David Michael, Vigil, Karen J, Berger, Daniel S, Bhatti, Laveeza, Campbell, Thomas, Casey, Kathleen K, Liu, Edward, Crofoot, Gordon E, Cunningham, Douglas, Feinberg, Judith, Fichtenbaum, Carl, Balamban Felizarta, Franco Antonio, Jefferson, Thomas T, Johnson, Marc Alexander, Lewis, Stanley T, Luque, Amneris E, Novak, Richard M, Sloan, Louis, Sweet, Donna E, Towner, William J, Zane, Ryan, Riedel, David J, Loftus, Richard Anton, Shon, Alyssa So Young, Mogyoros, Miguel, Tebas, Pablo, Scott, Mia Louise, Parenti, David M, Inciarte Portillo, Alexy, Cahn, Pedro, Lombaard, Johannes, Kumar, Sushma, Campbell, Havilland, Wan, Hong, Teal, Valerie, Jin Xu, Zhi, Asante-Appiah, Ernest, Sklar, Peter, Teppler, Hedy, and Lahoulou, Rima

Published
2024
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3. On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a post-hoc analysis of the ANRS IPERGAY trial

Author

Aboulker, Jean-Pierre, Bajos, Nathalie, Baril, Jean-Guy, Besnier, Michel, Binesse, Johan, Carette, Diane, Cattin, Grégoire, Chéret, Antoine, Chidiac, Christian, Choucair, Elias, Delfraissy, Jean-François, Demoulin, Baptiste, Diallo, Alpha, Durant-Zaleski, Isabelle, Doré, Véronique, Etien, Nicolas, Euphrasie, Françoise, Fonsart, Julien, Foubert, Valérie, Gibowski, Séverine, Girard, Gabriel, Guillon, Brigitte, Le Mestre, Soizic, Lert, France, Leturque, Nicolas, Lorente, Nicolas, Mennecier, Anaïs, Morin, Michel, Netzer, Emmanuelle, Otis, Joanne, Pasquet, Armelle, Peytavin, Gilles, Pialoux, Gilles, Préau, Marie, Rabian, Cécile, Rozenbaum, Willy, Sagaon-Teyssier, Luis, Saïdi, Yacine, Saouzanet, Marine, Simon, Marie-Christine, Suzan-Monti, Marie, Thompson, David, Timsit, Julie, Trottier, Benoît, Wainberg, Mark, Antoni, Guillemette, Tremblay, Cécile, Delaugerre, Constance, Charreau, Isabelle, Cua, Eric, Rojas Castro, Daniela, Raffi, François, Chas, Julie, Huleux, Thomas, Spire, Bruno, Capitant, Catherine, Cotte, Laurent, Meyer, Laurence, and Molina, Jean-Michel

Published
2020
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5. Doravirine versus ritonavir-boosted darunavir in antiretroviral-naive adults with HIV-1 (DRIVE-FORWARD): 96-week results of a randomised, double-blind, non-inferiority, phase 3 trial

Author

Hagins, Debbie P., Osiyemi, Olayemi O., Prelutsky, David James, Ramgopal, Moti N., Scarsella, Anthony John, Dretler, Robin, DeJesus, Edwin, Bettacchi, Christopher J., Sims, James, III, Clay, Patrick G., Bellos, Nicholaos C., Thompson, Melanie A., Montero, Jose, McDonald, Cheryl K., Creticos, Catherine, Shamblaw, David, Mogyoros, Miguel, Terrelonge, Antonio E., Valdes, Martin, Tashima, Karen T., Robbins, William J., Felizarta, Franco Antonio, Elion, Richard A., Slim, Jihad, Win, Sandra S., Lalla-Reddy, Sujata N., Ruane, Peter Jerome, Mills, Anthony, Cade, Jerry L., Dietz, Craig A., Rubin, David Scott, Mayer, Cynthia, Rondon, Juan Carlos, Cook, Paul P., Daar, Eric, Kumar, Princy N., Swindells, Susan, Castro, Jose Guillermo, Melendez-Rivera, Ivan, Morales-Ramirez, Javier O., Santiago, Lizette, Santana-Bagur, Jorge L., Martins, Marcelo, Cahn, Pedro Enrique, Lopardo, Gustavo D., Porteiro, Norma, Bloch, Mark Theo, Baker, David Alfred, Roth, Norman, Moore, Richard James, Finlayson, Robert James, McMahon, James, Rieger, Armin, Zoufaly, Alexander, Hartl, Sylvia, Zangerle, Robert, Smaill, Fiona, Walmsley, Sharon L., Conway, Brian, Rachlis, Anita, Smith, Graham H.R., Perez, Carlos, Afani, Alejandro, Campos, Maria Isabel, Chahin, Carolina Eugenia, Wolff Reyes, Marcelo, Gerstoft, Jan, Weis, Nina, Laursen, Alex Lund, Molina, Jean-Michel, Yazdanpanah, Yazdan, Cotte, Laurent, Raffi, Francois, Morlat, Philippe, Girard, Pierre-Marie, Katlama, Christine, Rockstroh, Juergen K., Arasteh, Keikawus, Esser, Stefan, Stoehr, Albrecht, Stellbrink, Hans-Juergen, Stoll, Matthias, Schuermann, Dirk, Faetkenheuer, Gerd, Bogner, Johannes, Lutz, Thomas, Baumgarten, Axel, Jaeger, Hans, Gori, Andrea, Coltan, Gabriel, Constandis, Felicia, Erscoiu, Simona Manuela, Prisacariu, Liviu-Jany, Rugina, Sorin, Streinu-Cercel, Adrian, Pokrovsky, Vadim Valentinovich, Zakharova, Natalia V., Shuldyakov, Andrey Anatolyevich, Ryamova, Elena Pavlovna, Kulagin, Valeriy Viktorovich, Tsybakova, Olga Aleksandrovna, Orlova-Morozova, Elena, Nagimova, Firaya, Voronin, Evgeniy, Shimonova, Tatyana Evgenyevna, Kozyrev, Oleg Anatolyevich, Orrell, Catherine, Lombaard, Johannes Jurgens, de Jager, Marleen, Portilla Segorb, Joaquin, Mallolas, Josep, Perez Elias, Maria Jesus, Gatell, Josep M., Arribas Lopez, Jose Ramon, Negredo Puigmal, Eugenia, Podzamczer Palter, Daniel, Pulido Ortega, Federico, Troya Garcia, Jesus, De los Santos Gil, Ignacio, Berenguer Berenguer, Juan, Williams, Ian G., Johnson, Margaret A., Schembri, Gabriel, Clarke, Amanda, Gompels, Mark, Fox, Julie Meriel, Taylor, Steven John, Dockrell, David Harold, Kegg, Stephen, Squires, Kathleen, Sax, Paul E, Cahn, Pedro, Lombaard, Johan, Lai, Ming-Tain, Rodgers, Anthony, Lupinacci, Lisa, Kumar, Sushma, Sklar, Peter, Hanna, George J, Hwang, Carey, and Martin, Elizabeth Anne

Published
2020
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6. Changes in kidney function among men having sex with men starting on demand tenofovir disoproxil fumarate--emtricitabine for HIV pre-exposure prophylaxis

Author

Liegeon, Geoffroy, Antoni, Guillemette, Pialoux, Gilles, Capitant, Catherine, Cotte, Laurent, Charreau, Isabelle, Tremblay, Cecile, Cua, Eric, Senneville, Eric, Raffi, Francois, Meyer, Laurence, and Molina, Jean-Michel

Subjects
Gilead Sciences Inc., Prophylaxis -- Research -- Analysis, Emtricitabine -- Research, HIV -- Research -- Drug therapy -- Risk factors, Tenofovir -- Research, Biological products industry -- Research -- Analysis, Health
Abstract

Introduction: Daily pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) is associated with a small but statistically significant decrease in estimated glomerular filtration rate (eGFR). We assessed the renal safety of on-demand PrEP with TDF/FTC in HIV-1 uninfected men. Methods: We used data from the randomized double-blind placebo-controlled ANRS-IPERGAY trial and its open-label extension conducted between February 2012 and June 2016 among HIV-uninfected MSM starting on-demand PrEP. Using linear mixed model, we evaluated the mean eGFR decline from baseline over time and determined risks factors associated with eGFR decline during the study. Results: During the blind phase, with a median follow-up of 9.4 months, the mean decline slope of eGFR from baseline was -0.88 and -1.53 mL/min/1.73 [m.sup.2] per year in the placebo (n = 201) and the TDF/FTC group (n = 198) respectively, with a slope difference of 0.65 mL/min/1.73 [m.sup.2] per year (p = 0.27). Including both phases, 389 participants started on-demand TDF/FTC with a median follow-up of 19.2 months and a mean decline of eGFR from baseline of -1.14 mL/min/1.73 [m.sup.2] per year (p < 0.001). The slope of eGFR reduction was not significantly different in participants with baseline eGFR [less than or equal to] 90 mL/min/1.73 [m.sup.2] (p = 0.44), age >40 years (p = 0.24) or hypertension (p = 0.21). There was a dose-response relationship between recent tenofovir exposure and lower eGFR when considering the number of pills taken in the two months prior the visit (eGFR difference of -0.88 mL/min/1.73 [m.sup.2] between >15 pills/month vs. [less than or equal to]15 pills/month, p < 0.01) or plasma tenofovir concentrations at the visit (eGFR difference compared to [less than or equal to]2 ng/mL: >2 to [less than or equal to]10ng/mL: -0.98 mL/min/1.73 [m.sup.2], >10 to [less than or equal to]40ng/mL: -1.28 mL/min/1.73 [m.sup.2], >40 ng/mL: -1.82 mL/min/1.73 [m.sup.2], p < 0.001). Three participants discontinued TDF/FTC for eGFR < 60 mL/min/1.73 [m.sup.2] during the OLE phase. No case of Fanconi syndrome was reported. Conclusions: The renal safety of on-demand PrEP with TDF/FTC was good. The overall reduction and intermittent exposure to TDF/FTC may explain this good renal safety. Keywords: PrEP; on-demand; intermittent; kidney; eGFR; tenofovir; HIV, 1 | INTRODUCTION Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF)--emtricitabine (FTC) raises a lot of expectations to hamper HIV epidemic due to its high effectiveness to prevent HIV acquisition [...]

Published
2020
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8. Doravirine versus ritonavir-boosted darunavir in antiretroviral-naive adults with HIV-1 (DRIVE-FORWARD): 48-week results of a randomised, double-blind, phase 3, non-inferiority trial

Author

Martins, Marcelo, Cahn, Pedro Enrique, Lopardo, Gustavo D., Porteiro, Norma, Bloch, Mark Theo, Baker, David Alfred, Roth, Norman, Moore, Richard James, Finlayson, Robert James, McMahon, James, Rieger, Armin, Zoufaly, Alexander, Hartl, Sylvia, Zangerle, Robert, Smaill, Fiona, Walmsley, Sharon L., Conway, Brian, Rachlis, Anita, Smith, Graham H.R., Perez, Carlos, Afani, Alejandro, Campos Barker, Maria Isabel E., Chahin, Carolina Eugenia, Wolff Reyes, Marcelo, Gerstoft, Jan, Weis, Nina, Laursen, Alex Lund, Molina, Jean-Michel, Yazdanpanah, Yazdan, Cotte, Laurent, Raffi, Francois, Morlat, Philippe, Girard, Pierre-Marie, Katlama, Christine, Rockstroh, Juergen K., Arasteh, Keikawus, Esser, Stefan, Stoehr, Albrecht, Stellbrink, Hans-Juergen, Stoll, Matthias, Schuermann, Dirk, Faetkenheuer, Gerd, Bogner, Johannes, Lutz, Thomas, Baumgarten, Axel, Jaeger, Hans, Gori, Andrea, Coltan, Gabriel, Constandis, Felicia, Erscoiu, Simona Manuela, Prisacariu, Liviu-Jany, Rugina, Sorin, Streinu-Cercel, Adrian, Pokrovsky, Vadim Valentinovich, Zakharova, Natalia V., Shuldyakov, Andrey Anatolyevich, Ryamova, Elena Pavlovna, Kulagin, Valeriy Viktorovich, Tsybakova, Olga Aleksandrovna, Orlova-Morozova, Elena, Nagimova, Firaya, Voronin, Evgeniy, Shimonova, Tatyana Evgenyevna, Kozyrev, Oleg Anatolyevich, Orrell, Catherine, Lombaard, Johannes Jurgens, Botes, Margaretha Elizabeth, Portilla, Joaquin, Gatell, Josep Maria, Perez, Maria Jesus, Arribas, Jose Ramon, Negredo, Eugenia, Podzamczer, Daniel, Pulido, Federico, Troya, Jesus, De los Santos, Ignacio, Berenguer, Juan, Williams, Ian G., Johnson, Margaret A., Schembri, Gabriel, Clarke, Amanda, Gompels, Mark, Fox, Julie Meriel, Taylor, Steven John, Kegg, Stephen, Hagins, Debbie P., Osiyemi, Olayemi O., Prelutsky, David James, Ramgopal, Moti N., Dretler, Robin, DeJesus, Edwin, Sloan, Louis, Lewis, Stanley T., Clay, Patrick G., Bellos, Nicholaos C., Thompson, Melanie A., Montero, Jose, McDonald, Cheryl K., Creticos, Catherine, Shamblaw, David, Terrelonge, Antonio E., Valdes, Martin, Tashima, Karen T., Robbins, William J., Felizarta, Franco Antonio, Elion, Richard A., Slim, Jihad, Lalezari, Jacob Paul, Lalla-Reddy, Sujata N., Ruane, Peter Jerome, Mills, Anthony, Cade, Jerry L., Campo, Rafael E., Dietz, Craig A., Blick, Gary, Mayer, Cynthia, Rondon, Juan Carlos, Cook, Paul P., Daar, Eric, Kumar, Princy N., Swindells, Susan, Castro, Jose Guillermo, Morales-Ramirez, Javier O., Santiago, Lizette, Santana-Bagur, Jorge L., Squires, Kathleen, Sax, Paul E, Cahn, Pedro, Lombaard, Johan, Lai, Ming-Tain, Xu, Xia, Rodgers, Anthony, Lupinacci, Lisa, Kumar, Sushma, Sklar, Peter, Nguyen, Bach-Yen, Hanna, George J, and Hwang, Carey

Published
2018
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9. Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial

Author

Pintado, C., Loze, B., Gatey, C., Ponscarme, D., Penot, P., Veron, R., Delgado, J., Dalle, E., Parlier, S., Madelaine, I., Danet, M., Mahjoub, N., Mezreb, N., Moudachirou, K., Morel, S., Conort, G., Lorho, F., Meunier, M., Rozenbaum, W., Monfort, C., Foucoin, J., Boissavy, B., Cousseau, S., Huon, S., Djessima, A., Berrebi, V., Adda, A., le Nagat, S., Zarka, L., Berdougo, J., Mzoughi, N., Clement, F., Decouty, A., Chapolard, C., Godinot, M., Adouard-groslafeige, C., Koffi, J., Pansu, A., Becker, A., Pailhes, S., Bonnet, F., Jeanblanc, F., Brochier, C., Teruin, X., Rouby, S., Gilly, L., Etienne, C., Tolonin, F., Breaud, S., Péchenot, V., Bagge, S., Cepitelli, T., Roger, PM., Rosenthal, E., Cheret, A., Cornavin, P., Vandamme, S., Lambec, J., Dumon, N., Leclanche, O., Huleux, T., Biekre, R., Melliez, H., Bazus, H., Pasquet, A., Bernaud, C., Besnier, M., Bonnet, B., Hall, N., Cavellec, M., Hue, H., Larmet, L., Colas, M., Choquet, R., Fouéré, S, Netzer, E., Leturque, N., Binesse, J., Foubert, V., Saouzanet, M., Euphrasie, F., Guillon, B., Saïdi, Y., Suzan, M., Cattin, G., Demoulin, B., Lorente, N., Molina, Jean-Michel, Charreau, Isabelle, Chidiac, Christian, Pialoux, Gilles, Cua, Eric, Delaugerre, Constance, Capitant, Catherine, Rojas-Castro, Daniela, Fonsart, Julien, Bercot, Béatrice, Bébéar, Cécile, Cotte, Laurent, Robineau, Olivier, Raffi, François, Charbonneau, Pierre, Aslan, Alexandre, Chas, Julie, Niedbalski, Laurence, Spire, Bruno, Sagaon-Teyssier, Luis, Carette, Diane, Mestre, Soizic Le, Doré, Veronique, and Meyer, Laurence

Published
2018
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14. Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study

Author

Meyer, L, Capitant, C, Charreau, I, Netzer, E, Leturque, N, Binesse, J, Foubert, V, Saouzanet, M, Euphrasie, F, Carette, D, Guillon, B, Saïdi, Y, Aboulker, J P, Spire, B, Suzan, M, Cattin, G, Demoulin, B, Sagaon-Teyssier, L, Lorente, N, Doré, V, Choucair, E, Le Mestre, S, Mennecier, A, Etien, N, Simon, M C, Diallo, A, Gibowski, S, Delfraissy, J F, Thompson, D, Sas, J, Pankovitch, J, Klein, M, Anis, A, Molina, Jean-Michel, Wainberg, Mark A, Trottier, Benoit, Tremblay, Cécile, Baril, Jean-Guy, Pialoux, Gilles, Cotte, Laurent, Chéret, Antoine, Pasquet, Armelle, Cua, Eric, Besnier, Michel, Rozenbaum, Willy, Chidiac, Christian, Delaugerre, Constance, Bajos, Nathalie, Timsit, Julie, Peytavin, Gilles, Fonsart, Julien, Durand-Zaleski, Isabelle, Meyer, Laurence, Aboulker, Jean-Pierre, Spire, Bruno, Suzan-Monti, Marie, Girard, Gabriel, Castro, Daniela Rojas, Préau, Marie, Morin, Michel, Thompson, David, Capitant, Catherine, Mennecier, Anaïs, Choucair, Elias, Doré, Véronique, Simon, Marie-Christine, Charreau, Isabelle, Otis, Joanne, Lert, France, Diallo, Alpha, Gibowski, Séverine, Rabian, Cecile, Chas, Julie, Tremblay, Cecile, Rojas-Castro, Daniela, Bernaud, Camille, Pintado, Claire, Sagaon-Teyssier, Luis, Mestre, Soizic Le, Ponscarme, Diane, and Doré, Veronique

Published
2017
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15. Direct-acting antiviral treatment against hepatitis C virus infection in HIV-Infected patients – “En route for eradication”?

Author

Cotte, L., Chidiac, C., Ferry, T., Ader, F., Biron, F., Boibieux, A., Miailhes, P., Perpoint, T., Schlienger, I., Lippmann, J., Braun, E., Koffi, J., Longuet, C., Guéripel, V., Augustin-Normand, C., Brochier, C., Degroodt, S., Pugliese, P., Ceppi, C., Cua, E., Cottalorda, J., Courjon, J., Dellamonica, P., Demonchy, E., De Monte, A., Durant, J., Etienne, C., Ferrando, S., Fuzibet, J.G., Garraffo, R., Joulie, A., Risso, K., Mondain, V., Naqvi, A., Oran, N., Perbost, I., Pillet, S., Prouvost-Keller, B., Wehrlen-Pugliese, S., Rosenthal, E., Sausse, S., Rio, V., Roger, P.M., Brégigeon, S., Faucher, O., Obry-Roguet, V., Orticoni, M., Soavi, M.J., Geneau de Lamarlière, P., Laroche, H., Ressiot, E., Carta, M., Ducassou, M.J., Jacquet, I., Gallie, S., Galinier, A., Ritleng, A.S., Ivanova, A., Blanco-Betancourt, C., Lions, C., Debreux, C., Poizot-Martin, I., Agher, R., Katlama, C., Valantin, M.A., Duvivier, C., Lortholary, O., Lanternier, F., Charlier, C., Rouzaud, C., Aguilar, C., Henry, B., Lebeaux, D., Cessot, G., Gergely, A., Consigny, P.H., Touam, F., Louisin, C., Alvarez, M., Biezunski, N., Cuzin, L., Debard, A., Delobel, P., Delpierre, C., Fourcade, C., Marchou, B., Martin-Blondel, G., Porte, M., Mularczyk, M., Garipuy, D., Saune, K., Lepain, I., Marcel, M., Puntis, E., Atoui, N., Casanova, M.L., Faucherre, V., Jacquet, J.M., Le Moing, V., Makinson, A., Merle De Boever, C., Montoya-Ferrer, A., Psomas, C., Reynes, J., Raffi, F., Allavena, C., Billaud, E., Biron, C., Bonnet, B., Bouchez, S., Boutoille, D., Brunet, C., Jovelin, T., Hall, N., Bernaud, C., Morineau, P., Reliquet, V., Aubry, O., Point, P., Besnier, M., Larmet, L., Hüe, H., Pineau, S., André-Garnier, E., Rodallec, A., Choisy, Ph., Vandame, S., Huleux, Th., Ajana, F., Alcaraz, I., Baclet, V., Huleux, T.H., Melliez, H., Viget, N., Valette, M., Aissi, E., Allienne, Ch., Meybeck, A., Riff, B., Bani-Sadr, F., Rouger, C., Berger, J.L., N'Guyen, Y., Lambert, D., Kmiec, I., Hentzien, M., Lebrun, D., Migault, C., Rey, D., Batard, M.L., Bernard-Henry, C., Cheneau, C., de Mautort, E., Fischer, P., Partisani, M., Priester, M., Lucht, F., Frésard, A., Botelho-Nevers, E., Gagneux-Brunon, A., Cazorla, C., Guglielminotti, C., Daoud, F., Lutz, M.F., Jacomet, C., Laurichesse, H., Lesens, O., Vidal, M., Mrozek, N., Corbin, V., Aumeran, C., Baud, O., Casanova, S., Coban, D., Hustache-Mathieu, L., Thiebaut-Drobacheff, M.C., Foltzer, A., Gendrin, V., Bozon, F., Chirouze, C., Abel, S., Cabié, A., Césaire, R., Santos, G. Dos, Fagour, L., Najioullah, F., Ouka, M., Pierre-François, S., Pircher, M., Rozé, B., Hoen, B., Ouissa, R., Lamaury, I., Pradat, Pierre, Pugliese, Pascal, Poizot-Martin, Isabelle, Valantin, Marc-Antoine, Cuzin, Lise, Reynes, Jacques, Billaud, Eric, Huleux, Thomas, Bani-Sadr, Firouze, Rey, David, Frésard, Anne, Jacomet, Christine, Duvivier, Claudine, Cheret, Antoine, Hustache-Mathieu, Laurent, Hoen, Bruno, Cabié, André, and Cotte, Laurent

Published
2017
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21. Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials

Author

Orkin, Chloe, Molina, Jean-Michel, Cahn, Pedro, Lombaard, Johannes, Supparatpinyo, Khuanchai, Kumar, Sushma, Campbell, Havilland, Wan, Hong, Teal, Valerie, Jin Xu, Zhi, Asante-Appiah, Ernest, Sklar, Peter, Teppler, Hedy, Lahoulou, Rima, Martins, Marcelo D, Cahn, Pedro E, Lopardo, Gustavo D, Porteiro, Norma, Bloch, Mark Theo, Baker, David Alfred, Roth, Norman, Moore, Richard J, Finlayson, Robert James, McMahon, James, Rieger, Armin, Zoufaly, Alexander, Schmied, Brigitte, Hartl, Sylvia, Zangerle, Robert, Smaill, Fiona, Walmsley, Sharon L, Conway, Brian, Rachlis, Anita, Smith, Graham H R, Perez Cortes, Carlos, Afani, Alejandro, Campos Barker, Maria Isabel E, Chahin Anania, Carolina Eugenia, Reyes, Marcelo J. Wolff, Gerstoft, Jan, Weis, Nina, Laursen, Alex Lund, Molina, Jean-Michel, Yazdanpanah, Yazdan, Cotte, Laurent, Raffi, Francois, Slama, Laurence, Morlat, Philippe, Girard, Pierre-Marie, Katlama, Christine, Rockstroh, Juergen K, Arasteh, Keikawus, Esser, Stefan, Stoehr, Albrecht, Stellbrink, Hans-Juergen, Stoll, Matthias, Schuermann, Dirk, Faetkenheuer, Gerd, Bogner, Johannes Richard, Lutz, Thomas, Baumgarten, Axel, Jaeger, Hans, Wiese, Carmen, Gori, Andrea, Migliorino, Guglielmo Marco, Coltan, Gabriel, Constandis, Felicia, Erscoiu, Simona M, Prisacariu, Liviu-Jany, Rugina, Sorin, Streinu-Cercel, Adrian, Pokrovsky, Vadim V, Zakharova, Natalia, Shuldyakov, Andrey Anatolyevich, Ryamova, Elena Pavlovna, Kulagin, Valeriy Viktorovich, Tsybakova, Olga Aleksandrovna, Orlova-Morozova, Elena, Nagimova, Firaya, Voronin, Evgeniy, Shimonova, Tatiana Evgenyevna, Kozyrev, Oleg Anatolyevich, Orrell, Catherine, Lombaard, Johannes Jurgens, Botes, Margaretha Elizabeth, de Jager, Marleen, Segorb, Joaquin Portilla, Gatell Artigas, Josep Maria, Mallolas Masferrer, Josep, Guillen, Santiago Moreno, Perez Elias, Maria Jesus, Arribas Lopez, Jose R, Puigmal, Eugenia Negredo, Podzamczer Palter, Daniel, Ortega, Frederico Pulido, Garcia, Jesus Troya, de los Santos Gil, Ignacio, Berenguer, Juan, Nelson, Mark Richard, Williams, Ian G, Johnson, Margaret A, Khoo, Saye, Schembri, Gabriel, Clarke, Amanda, Gompels, Mark, Fox, Julie Meriel, Lwanga, Julianne, Taylor, Steven John, Dockrell, David Harold, Kegg, Stephen, Hagins, Debbie P, Osiyemi, Olayemi O, Prelutsky, David James, Ramgopal, Moti N, Scarsella, Anthony J, Dretler, Robin, DeJesus, Edwin, Bettacchi, Christopher J, Sims III, James, Clay, Patrick G, Bellos, Nicholaos C, Thompson, Melanie A, Montero, Jose, McDonald, Cheryl K, Creticos, Catherine, Shamblaw, David, Terrelonge, Antonio E, Valdes, Martin, Tashima, Karen T, Robbins, William J, Elion, Richard A, Goldstein, Deborah, Slim, Jihad, Lalezari, Jacob Paul, Pushkin, Richard, Lalla-Reddy, Sujata N, Win, Sanda S, Ruane, Peter Jerome, Mills, Anthony Martin, Cade, Jerry L, Campo, Rafael, Dietz, Craig A, Hoffman-Terry, Margaret, Blick, Gary, Rubin, David Scott, Mayer, Cynthia, Rondon, Juan Carlos, Cook, Paul P, Daar, Eric, Kumar, Princy N, Swindells, Susan, Castro, Jose Guillermo, Morales-Ramirez, Javier O, Santiago, Lizette, Santana-Bagur, Jorge L, Vandekerckhove, Linos, Florence, Eric, De Wit, Stephane, Derdelinckx, Inge, Vandercam, Bernard, Belkhir, Leila, De Wet, Joseph, Lebouche, Bertrand, Trottier, Benoit, Longpre, Daniele, Szabo, Jason, LeBlanc, Roger P, Jensen, Werner, Gonzalez, Alvaro Rojas, Beltran, Carlos, Sussmann, Otto Alberto, Velez, Juan Diego, Onate, Jose Millan, Nielsen, Henrik, Degen, Olaf, Stephan, Christoph, Arathoon, Eduardo, Lopez, Rudy Manuel, Rojas Alvarado, Evelyn Michelle, Gonzalez Patzan, Luis Demetrio, Meija, Carlos R, Pinzon, Rodolfo, Parchment, Charles, Sthoeger, Zev, Chowers, Michal, Riesenberg, Klaris, Shahar, Eduardo, Levy, Itzchak, Quintero Perez, Nora Patricia, Andrade-Villanueva, Jaime Federico, Crabtree Ramirez, Brenda Eloisa, Rijnders, Bart, den Hollander, Jan G, Handy, Rupert, Morales, Nilo Bonifacio, Hidalgo, Jose Alfredo, Infante, Rosa Mercedes, Matos Prado, Eduardo Demetrio, Campos, Pablo E, Ticona Chaves, Eduardo Romulo, Pinedo, Yvett, Pacheco, Patricia, Maltez, Fernando Manuel, Cunha, Jose, Neves, Isabel, Serrao, Rosario, Melendez-Rivera, Ivan, Mendoza-Rodriguez, Rafael O, Maldonado-Rivera, Sandra, Ortiz-Lasanta, Grisell, Kizhlo, Svetlana, Freud, Hernando Knobel, Moreno, Jose Sanz, Mendez, Francisco Vera, Mohapi, Lerato, Mitha, Essack Aziz, Mahomed, Akbar Anvar, Fouche, Leon Frederik, Kaplan, Richard, Siddique, Naeem, Hoosen, Farzana, Rassool, Mohammed Siddique, Baraldi, Ezio, Calmy, Alexandra, Cavassini, Matthias, Fehr, Jan, Tsai, Hung-Chin, Lin, Hsi-Hsun, Huang, Chun-Kai, Ko, Wen-Chien, Lin, Yu-Hui, Chen, Su-Jung, Hung, Chien-Ching, Avihingsanon, Anchalee, Kiertiburanakul, Sasisopin, Ratanasuwan, Winai, Supparatpinyo, Khuanchai, Chetchotisakd, Ploenchan, Changpradub, Dhitiwat, Orkin, Chloe, Fox, Ashini, Winston, Alan, Ustianowski, Andrew, Yangco, Bienvenido G, Asmuth, David Michael, Vigil, Karen J, Berger, Daniel S, Bhatti, Laveeza, Campbell, Thomas, Casey, Kathleen K, Liu, Edward, Crofoot, Gordon E, Cunningham, Douglas, Feinberg, Judith, Fichtenbaum, Carl, Balamban Felizarta, Franco Antonio, Jefferson, Thomas T, Johnson, Marc Alexander, Lewis, Stanley T, Luque, Amneris E, Novak, Richard M, Sloan, Louis, Sweet, Donna E, Towner, William J, Zane, Ryan, Riedel, David J, Loftus, Richard Anton, Shon, Alyssa So Young, Mogyoros, Miguel, Tebas, Pablo, Scott, Mia Louise, Parenti, David M, and Inciarte Portillo, Alexy

Abstract

In two phase 3 trials for first-line therapy in adults with HIV-1, doravirine showed non-inferior efficacy, a favourable safety profile, and a superior lipid profile to darunavir and efavirenz through to 48 and 96 weeks. Here we report 192-week results from both studies.

Published
2024
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22. HIV therapeutic vaccine enhances non-exhausted CD4+ T cells in a randomised phase 2 trial

Author

Vieillard, Vincent, Combadière, Béhazine, Tubiana, Roland, Launay, Odile, Pialoux, Gilles, Cotte, Laurent, Girard, Pierre-Marie, Simon, Anne, Dudoit, Yasmine, Reynes, Jacques, Rockstroh, Jürgen, Garcia, Felipe, Gatell, Jose, Devidas, Alain, Yazdanpanah, Yazdan, Weiss, Laurence, Fätkenheuer, Gerd, Autran, Brigitte, Joyeux, Delphine, Gharakhanian, Shahin, Debré, Patrice, and Katlama, Christine

Published
2019
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24. In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control

Author

Trémeaux, Pauline, primary, Lemoine, Frédéric, additional, Mélard, Adeline, additional, Gousset, Marine, additional, Boufassa, Faroudy, additional, Orr, Sylvie, additional, Monceaux, Valérie, additional, Gascuel, Olivier, additional, Lambotte, Olivier, additional, Hocqueloux, Laurent, additional, Saez-Cirion, Asier, additional, Rouzioux, Christine, additional, Avettand-Fenoel, Véronique, additional, Bani-Sadr, Firouzé, additional, Hentzien, Maxime, additional, Berger, Jean-Luc, additional, Kmiec, Isabelle, additional, Pichancourt, Gilles, additional, Nasri, Safa, additional, Hittinger, Gilles, additional, Lambry, Véronique, additional, Beaudrey, Anne-Cécile, additional, Pialoux, Gilles, additional, Chas, Julie, additional, Palacios, Christia, additional, Adda, Anne, additional, Viard, Jean Paul, additional, Dulucq, Marie-Josée, additional, Weiss, Laurence, additional, Karmochkine, Marina, additional, Meghadecha, Mohamed, additional, Salmon-Ceron, Dominique, additional, Piétri, Marie-Pierre, additional, Blanche, Philippe, additional, Molina, Jean-Michel, additional, Taulera, Olivier, additional, Ponscarme, Diane, additional, Delgado Bertaut, Jeannine, additional, Makhloufi, Djamila, additional, Godinot, Matthieu, additional, Artizzu, Valérie, additional, Miailhes, Patrick, additional, Cotte, Laurent, additional, Pailhes, Sophie, additional, Conrad, Anne, additional, Karkowski, Ludovic, additional, Ogoudjobi, Stanislas, additional, Yazdanpanah, Yazdan, additional, Matheron, Sophie, additional, Godard, Cindy, additional, Bernard, Louis, additional, Bastides, Frédéric, additional, Bourgault, Olivier, additional, Jacomet, Christine, additional, Goncalves, Emilie, additional, Chavanet, Pascal, additional, Piroth, Lionel, additional, Gohier, Sandrine, additional, Meybeck, Agnès, additional, Huleux, Thomas, additional, Cornavin, Pauline, additional, Debab, Yasmine, additional, Théron, David, additional, Prazuck, Thierry, additional, De Dieuleveult, Barbara, additional, Faller, Jean-Pierre, additional, Eglinger, Patricia, additional, Roblot, Pascal, additional, Plainchamp, David, additional, Aumaître, Hugues, additional, Malet, Martine, additional, Rouger, Christine, additional, Rémy, Gérard, additional, Isabelle, Melle Kmiec, additional, Delassus, Jean-Luc, additional, Devidas, Alain, additional, Froguel, Eric, additional, Tassi, Sylvie, additional, Genet, Philippe, additional, Gerbe, Juliette, additional, Patey, Olivier, additional, Laurent, Richier, additional, Drobacheff, Marie-Christine, additional, Proust, Aurélie, additional, Gil, Helder, additional, Gérard, Laurence, additional, Oksenhendler, Eric, additional, Lascoux, Caroline, additional, Parlier, Sylvie, additional, Lucht, Frédéric, additional, Ronat, Véronique, additional, Dupon, Michel, additional, Dutronc, Hervé, additional, Le Puil, Séverine, additional, Neau, Didier, additional, Mercié, Patrick, additional, Morlat, Philippe, additional, Caldato, Sabrina, additional, Schmit, Jean-Luc, additional, Decaux, Nathalie, additional, Bru, Jean-Pierre, additional, Clavere, Gaëlle, additional, Delfraissy, Jean-François, additional, Goujard, Cécile, additional, Bourdic, Katia, additional, Vittecoq, Daniel, additional, Bolliot, Claudine, additional, Lambert, Thierry, additional, Bergmann, Jean-François, additional, Parrinello, Maguy, additional, Welker, Yves, additional, Lafeuillade, Alain, additional, Philip, Gisèle, additional, Rapp, Christophe, additional, Lerondel, Melle, additional, de Truchis, Pierre, additional, Huguette, Berthe, additional, Jeantils, Vincent, additional, Mchangama, Fatouma, additional, Consigny, Paul Henri, additional, Touam, Fatima, additional, le Nagat, Sophie, additional, Bouchaud, Olivier, additional, Honoré, Patricia, additional, Boué, François, additional, Raho-Moussa, Mariem, additional, Viard, Jean-Paul, additional, Cros, Agnès, additional, Salmon-Céron, Dominique, additional, Pietri, Marie-Pierre, additional, Collias, Lio, additional, Zucman, David, additional, Blétry, Olivier, additional, Bornarel, Dominique, additional, Mortier, Emmanuel, additional, Feng, Zeng, additional, Lelièvre, Jean-Daniel, additional, Katlama, Christine, additional, Dudoit, Yasmine, additional, Simon, Anne, additional, Lupin, Catherine, additional, Girard, Pierre-Marie, additional, Pauchard, Michèle, additional, Abel, Sylvie, additional, Cabié, André, additional, Fialaire, Pascale, additional, Chennebault, Jean-Marie, additional, Rehaiem, Sami, additional, de Saint Martin, Luc, additional, Perfezou, ••••, additional, Duthe, Jean-Charles, additional, Weinbreck, Pierre, additional, Genet, Claire, additional, Garnier, Florence, additional, Poizot-Martin, Isabelle, additional, Fauche, Olivia, additional, Ivanova, Alena, additional, Philibert, Patrick, additional, Penda Sow, Mame, additional, Yeni, Patrick, additional, Godard, Cyndi, additional, Raffi, François, additional, Hüe, Hervé, additional, Perré, Philippe, additional, Roger, Pierre Marie, additional, Joulie, Aline, additional, Rosenthal, Éric, additional, Michelet, Christian, additional, Souala, Faouzi, additional, Ratajczak, Maja, additional, Partisani, Marialuisa, additional, Fischer, Patricia, additional, Nau, Pascale, additional, Delobel, Pierre, additional, Balsarin, Florence, additional, De Lavaissiere, Marc, additional, Verdon, Renaud, additional, Feret, Philippe, additional, Leclercq, Pascale, additional, Gerberon, ••••, additional, Meybeck, Agnés, additional, Biekre, Raphaël, additional, May, Thierry, additional, Bouillon, ••••, additional, Caron, François, additional, Theron, David, additional, Gatfosse, Marc, additional, Martinot, Martin, additional, Pachart, Anne, additional, Poubeau, Patrice, additional, Gaud, Catherine, additional, Uludag, Agnès, additional, Arsac, Philippe, additional, Bouaraba, Lydia, additional, de Dieulevault, Barbara, additional, De Lacroix Szmania, Isabelle, additional, Richier, Laurent, additional, Daneluzzi, Vincent, additional, Rouveix, Elisabeth, additional, Beck-Wirth, Geneviève, additional, Romand, Philippe, additional, Blum, Laurent, additional, Deschaud, Martine, additional, Michau, Christophe, additional, Bernard, Christian, additional, Salaun, Florence, additional, Muller, Philippe, additional, Poinsignon, Yves, additional, Lepretre, Annie, additional, Sotto, Albert, additional, Doncesco, ••••, additional, Perfezou, Pascale, additional, Duthe, Jean Charles, additional, Niault, Mathilde Aurore, additional, Mouton-Rioux, Virginie, additional, Talarmin, Jean-Philippe, additional, Duthé, Jean Charles, additional, Dupont, Mathilde, additional, Natur, Stéphane, additional, Hitoto, Hikombo, additional, and Ibrahim, Ali Mahamadou, additional

Published
2023
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25. Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

Author

Molinos-Albert, Luis, Lorin, Valerie, Monceaux, Valérie, Orr, Sylvie, Essat, Asma, Dufloo, Jérémy, Schwartz, Olivier, Rouzioux, Christine, Meyer, Laurence, Hocqueloux, Laurent, Sáez-Cirión, Asier, Mouquet, Hugo, Group, Anrs Visconti Study, Prazuck, Thierry, Dieuleveult, Barbara De, Bani-Sadr, Firouzé, Hentzien, Maxime, Berger, Jean-Luc, Kmiec, Isabelle, Pichancourt, Gilles, Nasri, Safa, Hittinger, Gilles, Lambry, Véronique, Beauey, Anne-Cécile, Pialoux, Gilles, Palacios, Christia, Siguier, Martin, Adda, Anne, Foucoin, Jane, Weiss, Laurence, Karmochkine, Marina, Meghadecha, Mohamed, Ptak, Magali, Salmon-Ceron, Dominique, Blanche, Philippe, Piétri, Marie-Pierre, Molina, Jean-Michel, Taulera, Olivier, Lascoux-Combe, Caroline, Ponscarme, Diane, Bertaut, Jeannine Delgado, Makhloufi, Djamila, Godinot, Matthieu, Artizzu, Valérie, Yazdanpanah, Yazdan, Matheron, Sophie, Godard, Cindy, Julia, Zélie, Bernard, Louis, Bastides, Frédéric, Bourgault, Olivier, Jacomet, Christine, Goncalves, Emilie, Meybeck, Agnès, Huleux, Thomas, Cornavin, Pauline, Debab, Yasmine, Théron, David, Miailhes, Patrick, Cotte, Laurent, Pailhes, Sophie, Ogoudjobi, Stanislas, Viard, Jean Paul, Dulucq, Marie-Josée, Bodard, Loïc, Churaqui, Francoise, Guimard, Thomas, Laine, Laetitia, Immunologie humorale - Humoral Immunology, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), HIV, Inflammation et persistance - HIV, Inflammation and Persistence, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Virus et Immunité - Virus and immunity (CNRS-UMR3569), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service de Microbiologie Clinique [Paris], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), La Source Hospital-CHR, Centre Hospitalier Universitaire de Reims (CHU Reims), Centre Hospitalier Henri Duffaut (Avignon), CHI de Toulon, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hopital Saint-Louis [AP-HP] (AP-HP), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Centre Hospitalier Gustave Dron [Tourcoing], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Hôpital de la Croix-Rousse [CHU - HCL], Hôpital Hôtel-Dieu [Paris], Institut mutualiste Monsouris (IMM), Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée), We thank the NIH AIDS Reagent Program (Division of AIDS, NIAID, NIH) for contributing to reagents and the Agence National de Recherche sur le SIDA et les hépatites virales (ANRS) for an equipment grant support (AO2013-2 #13553, H.M.). L.M. M-A. is the recipient of a postdoctoral fellowship from the Pasteur-Roux-Cantarini program (Institut Pasteur). H.M. received core grants from the Institut Pasteur, the INSERM and the Milieu Intérieur Program (ANR-10-LABX-69-01). This work was conducted in the context of the ANRS RHIVIERA consortium, and was supported by the ANRS and the NIH/NIAID (grant #: P01AI131365, H.M.)., ANRS VISCONTI Study Group Thierry Prazuck, Barbara De Dieuleveult, Firouzé Bani-Sadr, Maxime Hentzien, Jean-Luc Berger, Isabelle Kmiec, Gilles Pichancourt, Safa Nasri, Gilles Hittinger, Véronique Lambry, Anne-Cécile Beauey, Gilles Pialoux, Christia Palacios, Martin Siguier, Anne Adda, Jane Foucoin, Laurence Weiss, Marina Karmochkine, Mohamed Meghadecha, Magali Ptak, Dominique Salmon-Ceron, Philippe Blanche, Marie-Pierre Piétri, Jean-Michel Molina, Olivier Taulera, Caroline Lascoux-Combe, Diane Ponscarme, Jeannine Delgado Bertaut, Djamila Makhloufi, Matthieu Godinot, Valérie Artizzu, Yazdan Yazdanpanah, Sophie Matheron, Cindy Godard, Zélie Julia, Louis Bernard, Frédéric Bastides, Olivier Bourgault, Christine Jacomet, Emilie Goncalves, Agnès Meybeck, Thomas Huleux, Pauline Cornavin, Yasmine Debab, David Théron, Patrick Miailhes, Laurent Cotte, Sophie Pailhes, Stanislas Ogoudjobi, Jean Paul Viard, Marie-Josée Dulucq, Loïc Bodard, Francoise Churaqui, Thomas Guimard & Laetitia Laine, ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Institut Pasteur [Paris]-Université Paris Cité (UPC), Virus et Immunité - Virus and immunity, and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPC)

Subjects
Multidisciplinary, MESH: Humans, General Physics and Astronomy, HIV Infections, General Chemistry, MESH: HIV Infections, Antibodies, Neutralizing, General Biochemistry, Genetics and Molecular Biology, Immunity, Humoral, MESH: Antibodies, Neutralizing, MESH: HIV-1, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, HIV-1, Humans, Viremia, MESH: Immunity, Humoral, MESH: Viremia
Abstract

HIV-1 post-treatment controllers are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control in post-treatment controllers could aid in designing effective HIV-1 vaccine and remission strategies. Here, we perform comprehensive immunoprofiling of the humoral response to HIV-1 in long-term post-treatment controllers. Global multivariate analyses combining clinico-virological and humoral immune data reveal distinct profiles in post-treatment controllers experiencing transient viremic episodes off therapy compared to those stably aviremic. Virally-exposed post-treatment controllers display stronger HIV-1 humoral responses, and develop more frequently Env-specific memory B cells and cross-neutralizing antibodies. Both are linked to short viremic exposures, which are also accompanied by an increase in blood atypical memory B cells and activated subsets of circulating follicular helper T cells. Still, most humoral immune variables only correlate with Th2-like circulating follicular helper T cells. Thus, post-treatment controllers form a heterogeneous group with two distinct viral behaviours and associated immune signatures. Post-treatment controllers stably aviremic present “silent” humoral profiles, while those virally-exposed develop functionally robust HIV-specific B-cell and antibody responses, which may participate in controlling infection.

Published
2022
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26. Outcomes of post-exposure vaccination by modified vaccinia Ankara to prevent mpox (formerly monkeypox): a retrospective observational study in Lyon, France, June to August 2022

Author

Merad, Yanis, primary, Gaymard, Alexandre, additional, Cotte, Laurent, additional, Perpoint, Thomas, additional, Alfaiate, Dulce, additional, Godinot, Matthieu, additional, Becker, Agathe, additional, Cannesson, Olivier, additional, Batalla, Anne-Sophie, additional, Oria-Yassir, Fatima, additional, Landré, Sophie, additional, Morfin, Florence, additional, Bouscambert, Maude, additional, Valour, Florent, additional, Ader, Florence, additional, and Conrad, Anne, additional

Published
2022
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27. Hepatitis A and B vaccine uptake and immunisation among men who have sex with men seeking PrEP: a substudy of the ANRS IPERGAY trial

Author

Le Turnier, Paul, primary, Charreau, Isabelle, additional, Gabassi, Audrey, additional, Carette, Diane, additional, Cotte, Laurent, additional, Pialoux, Gilles, additional, Tremblay, Cécile, additional, Spire, Bruno, additional, Chaix, Marie-Laure, additional, Meyer, Laurence, additional, Capitant, Catherine, additional, Delaugerre, Constance, additional, Raffi, François, additional, and Molina, Jean-Michel, additional

Published
2022
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30. Telaprevir for HIV/Hepatitis C Virus–Coinfected Patients Failing Treatment With Pegylated Interferon/Ribavirin (ANRS HC26 TelapreVIH): An Open-Label, Single-Arm, Phase 2 Trial

Author

French National Agency for Research on AIDS and Viral Hepatitis (ANRS) HC26 Study Group, Cotte, Laurent, Braun, Joséphine, Lascoux-Combe, Caroline, Vincent, Corine, Valantin, Marc-Antoine, Sogni, Philippe, Lacombe, Karine, Neau, Didier, Aumaitre, Hugues, Batisse, Dominique, de Truchis, Pierre, Gervais, Anne, Michelet, Christian, Morlat, Philippe, Vittecoq, Daniel, Rosa, Isabelle, Bertucci, Inga, Chevaliez, Stéphane, Aboulker, Jean-Pierre, and Molina, Jean-Michel

Published
2014

32. Epidemiological impact of Neisseria gonorrhoeaeand Chlamydia trachomatisscreening in men having sex with men: a modelling study

Author

Flaig, Julien, Hocqueloux, Laurent, Palich, Romain, Cuzin, Lise, Robineau, Olivier, Pugliese, Pascal, Delpierre, Cyrille, Voirin, Nicolas, and Cotte, Laurent

Abstract

ObjectivesThe impact of the systematic screening of Neisseria gonorrhoeae(NG) and Chlamydia trachomatis(CT) in men having sex with men (MSM) on these pathogens’ epidemiology remains unclear. We conducted a modelling study to analyse this impact in French MSM.MethodsWe modelled NG and CT transmission using a site-specific deterministic compartmental model. We calibrated NG and CT prevalence at baseline using results from MSM enrolled in the Dat’AIDS cohort. The baseline scenario was based on 1 million MSM, 40 000 of whom were tested every 90 days and 960 000 every 200 days. Incidence rate ratios (IRRs) at steady state were simulated for NG, CT, NG and/or CT infections, for different combinations of tested sites, testing frequency and numbers of frequently tested patients.ResultsThe observed prevalence rate was 11.0%, 10.5% and 19.1% for NG, CT and NG and/or CT infections. The baseline incidence rate was estimated at 138.2 per year per 100 individuals (/100PY), 86.8/100PY and 225.0/100PY for NG, CT and NG and/or CT infections. Systematically testing anal, pharyngeal and urethral sites at the same time reduced incidence by 14%, 23% and 18% (IRR: 0.86, 0.77 and 0.82) for NG, CT and NG and/or CT infections. Reducing the screening interval to 60 days in frequently tested patients reduced incidence by 20%, 29% and 24% (IRR: 0.80, 0.71 and 0.76) for NG, CT and NG and/or CT infections. Increasing the number of frequently tested patients to 200 000 reduced incidence by 29%, 40% and 33% (IRR: 0.71, 0.60 and 0.67) for NG, CT and NG and/or CT infections. No realistic scenario could decrease pathogens’ incidence by more than 50%.ConclusionsTo curb the epidemic of NG and CT in MSM, it would not only be necessary to drastically increase screening, but also to add other combined interventions.

Published
2024
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33. Missed opportunities for HIV pre‐exposure prophylaxis among people with recent HIV infection: The French ANRS 95041 OMaPrEP study

Author

Lions, Caroline, primary, Laroche, Helene, additional, Mora, Marion, additional, Pialoux, Gilles, additional, Cotte, Laurent, additional, Cua, Eric, additional, Piroth, Lionel, additional, Molina, Jean Michel, additional, Salnikova, Maria, additional, Maradan, Gwenaëlle, additional, Poizot‐Martin, Isabelle, additional, and Spire, Bruno, additional

Published
2022
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35. Smoking‐associated morbidities on computed tomography lung cancer screens in HIV‐infected smokers

Author

Bommart, S, Cournil, A, Eymard‐Duvernay, S, Raffi, F, Bouassida, I, Le Moing, V, Reynes, J, Makinson, A, Yazdanpanah, Yazdan, Cheret, Antoine, Ajana, Faïza, Alcaraz, Isabelle, Baclet, Véronique, Melliez, Hugues, Valette, Michel, Viget, Nathalie, De La Tribonniere, Xavier, Huleux, Thomas, Séverine, Séverine Bonne, Biekre, Raphaël, Pasquet, Armelle, Allienne, Christophe, Behra, Jean Marie, Meybeck, Agnès, Aissi, Emmanuelle, Abgrall, Sophie, Bouchaud, Olivier, Barruet, Régine, Rouges, François, Kandel, Tania, Mechai, Fréderic, Brillet, Pierre‐Yves, Brauner, Michel, Dellamonica, Pierre, De Salvador, Francine, Cua, Eric, Leplatois, Anne, Naqvi, Alissa, Durant, Jacques, Ceppi, Carole, Sanderson, Frédéric, Rosenthal, Eric, Chassang, Madleen, Chevallier, Patrick, Dunais, Brigitte, Tattevin, Pierre, Lena, Hervé, Lentz, Pierre‐Axel, Michelet, Christian, Arvieux, Cédric, Revest, Mathieu, Soula, Faouzi, Chapplain, Jean‐Marc, Leroy, Hélène, Meunier, Catherine, Poizot‐Martin, Isabelle, Faucher, Olivia, Menard, Amélie, Bregigeon, Sylvie, de Lamarliere, Perrine Geneau, Champsaur, Pierre, Durieux, Olivier, Cloarec, Nicolas, Allavena, Clotilde, Feuillebois, Nicolas, Mounoury, Olivier, Bouchez, Sabelline, Billaud, Eric, Reliquet, Véronique, Bonnet, Bénédicte, Brunet, Cécile, Point, Patrick, Boutoille, David, Le Houssine, Pascale Morineau, Delemazure, Anne Sophie, Duvivier, Claudine, Catherinot, Emilie, Tehrani, Michka Shoai, Poiree, Sylvain, Zucman, David, Majerholc, Catherine, Couderc, Louis‐Jean, Mellot, François, Sherrer, Antoine, Ferry, Tristan, Koffi, Joseph, Boibieux, André, Miailhes, Patrick, Cotte, Laurent, Perpoint, Thomas, Lippman, Joanna, Norman, Claude Augustin, biron, Francois, Senechar, Agathe, Ader, Florence, Pialloux, Gilles, LʼYavanc, Thomas, Slama, Laurence, Chas, Julie, Le Nagat, Sophie, Khalil, Antoine, Carette, Marie France, Bonnet, Fabrice, Morlat, Philippe, Lacoste, Denis, Vandenhende, Marie, Receveur, Marie Catherine, Paccalin, Francois, Caldato, Sabrina, Bernard, Noëlle, Hessemfar, Mojgan, Pistone, Thierry, Malvy, Denis, Thibaut, Pierre, Pertusa, Marie Carmen, Cornelou, Olivier, Laurent, Francois, Mercie, Patrick, Faure, Isabelle, Dondia, Denis, Martell, Cedric, Duffau, Pierre, Mauboussin, Jean Marc, Barbuat, Claudine, Rouanet, Isabelle, Metge, Liliane, Jacquet, Jean‐Marc, Atoui, Nadine, Loriette, Mickael, Morquin, David, Fauchere, Vincent, Favier, Carine, Merle, Corinne, Baillat, Vincent, Silva, Antoine Da, Mansouri, Rachid, Kovacsik‐Vernhet, Hélène, Pujol, Jean‐Louis, Quantin, Xavier, and Hayot, Maurice

Published
2017
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42. High syphilis prevalence and incidence in people living with HIV and Preexposure Prophylaxis users: A retrospective review in the French Dat’AIDS cohort

Author

Lemmet, Thomas, primary, Cotte, Laurent, additional, Allavena, Clotilde, additional, Huleux, Thomas, additional, Duvivier, Claudine, additional, Laroche, Hélène, additional, Cabie, André, additional, Pugliese, Pascal, additional, Jovelin, Thomas, additional, Maurel, Marine, additional, Delpierre, Cyrille, additional, and Rey, David, additional

Published
2022
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44. Six-month antibody response to SARS-CoV-2 in healthcare workers assessed by virus neutralization and commercial assays

Author

Fascia Pascal, Adnot Jérôme, Fontaine Juliette, Massardier-Pilonchéry Amélie, Boibieux André, Josset Laurence, Nicolas Guibert, Oria Fatima, Nazare Julie-Anne, Chiarello Pierre, Samperiz Audrey, Antonin Bal, Prudent Mélanie, Simon Chantal, Dulce Alfaiate, Fassier Jean-Baptiste, Florence Morfin-Sherpa, Constance d'Aubarede, Brunel-Dalmas Florence, Lahousse Matthieu, Pitiot Virginie, Trabaud Mary-Anne, Gaillot-Durand Lucie, Bal Antonin, Lina Bruno, Trouillet-Assant Sophie, Gueyffier François, Perry Marielle, Gillet Myriam, Adèle Paul, Jean-Baptiste Fassier, Valette Martine, Bourgeois Gaëlle, Lozano Hélène, Kahina Saker, Alfaiate Dulce, Morfin Florence, Mary-Anne Trabaud, Rabilloud Muriel, Schlienger Isabelle, Narbey David, Durupt François, Makhloufi Djamila, Bruno Pozzetto, Paul Adèle, Caire Eurydice, Bergeret Alain, Godinot Matthieu, Escuret Vanessa, Bonnet Florent, Moll Frédéric, Guibert Nicolas, Gaymard Alexandre, Cotte Laurent, Sophie Trouillet-Assant, Muriel Rabilloud, Virginie Pitiot, Amélie Massardier-Pilonchery, Milon Marie-Paule, Charbotel Barbara, Carole Langlois-Jacques, Bruno Lina, Hospices Civils de Lyon (HCL), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR_T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Gustave Eiffel, Université de Lyon, Institut des Agents Infectieux [Lyon] (IAI), Service de médecine et santé au travail, hospices civils de Lyon, Laboratoire de virologie, Physiopathologie et biothérapies des infections muqueuses (GIMAP), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)

Subjects
Male, Time Factors, Antibodies, Viral, Neutralization, MEDECINE, Health personnel, 0302 clinical medicine, SANTE, SARS-COV2, Medicine, 030212 general & internal medicine, Letter to the Editor, 0303 health sciences, biology, PERSONNEL DE SANTE, virus diseases, General Medicine, Middle Aged, University hospital, TRAVAIL, 3. Good health, Titer, Infectious Diseases, Female, Antibody, Serological assays, ANTICORPS, Adult, Microbiology (medical), 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Health Personnel, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), education, GESTION DU PERSONNEL, Virus Neutralization, Virus, 03 medical and health sciences, Neutralization Tests, Seroprevalence, Humans, Healthcare workers, Virus neutralisation assay, 030304 developmental biology, SARS-CoV-2, business.industry, COVID-19, Antibodies, Neutralizing, Virology, Antibody response, biology.protein, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

We conducted a prospective study in healthcare workers (n=296) of the University Hospital of Lyon, France. Serum samples (n=296) collected six months after disease onset were tested using three commercial assays: the Wantai Ab assay detecting total antibodies against the receptor binding domain (RBD) of the S protein, the bioMerieux Vidas assay detecting IgG to the RBD and the Abbott Architect assay detecting IgG to the N protein. The neutralising antibody (NAb) titre was also determined for all samples with a virus neutralisation assay (VNA) using live virus. The positivity rate was 100% with the Wantai assay, 84.8% with the bioMerieux assay and 55.4% with the Abbott assay. Only 51% of HCWs were positive for the presence of NAb. Less than 10 % of HCWs had a NAb titre greater than 80. At a neutralising titre of 80, the area under the curves [IC 95%] was 0.71 [0.62-0.81], 0.75 [0.65-0.85] and 0.95 [0.92-0.97] for Wantai, Abbott and Vidas respectively. The data presented herein suggest that commercial assays detecting antibodies against the N protein must not be used in long-term seroprevalence surveys while the Wantai assay could be useful for this purpose. VNA should remain the gold standard to assess the protective antibody response, but some commercial assays could be used as first-line screening of long-term presence of NAb.

Published
2021
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48. Missed opportunities for HIV pre‐exposure prophylaxis among people with recent HIV infection: The French ANRS 95041 OMaPrEP study.

Author

Lions, Caroline, Laroche, Helene, Mora, Marion, Pialoux, Gilles, Cotte, Laurent, Cua, Eric, Piroth, Lionel, Molina, Jean Michel, Salnikova, Maria, Maradan, Gwenaëlle, Poizot‐Martin, Isabelle, and Spire, Bruno

Subjects
HIV prevention, HIV infection risk factors, HIV-positive persons, STATISTICS, CONFIDENCE intervals, MULTIPLE regression analysis, AGE distribution, RETROSPECTIVE studies, MEDICAL screening, PRE-exposure prophylaxis, HEALTH literacy, DESCRIPTIVE statistics, QUESTIONNAIRES, RESEARCH funding, MEN who have sex with men, ODDS ratio, SECONDARY analysis
Abstract

Objectives: Our objective was to identify missed opportunities for the use of pre‐exposure prophylaxis (PrEP) in people with recently acquired HIV, factors associated with PrEP knowledge, and reasons for not using PrEP. Design: This was a French national cross‐sectional multicentre study enrolling people diagnosed with recent HIV (incomplete Western blot or negative HIV test in the previous 6 months) in 28 HIV clinical centres. Data were gathered using a self‐administered questionnaire (SAQ). Method: We analysed missed opportunities for PrEP use via a retrospective prep cascade. Factors associated with prior knowledge of PrEP and reasons for PrEP non‐use among those who knew about PrEP were described using univariate and multivariate logistic regression models. Results: Of the 224 eligible patients, 185 completed the SAQ and 168 (91%) were eligible for PrEP. Of these, 90% reported seeing at least one physician during the previous year, 26% received information about PrEP, and 5% used PrEP. Factors independently associated with a higher probability of knowing about PrEP were being a man who has sex with men, being aged 25–30 years (vs older), undergoing HIV screening at least once every semester (vs less often; odds ratio [OR] 4.11; 95% confidence interval [CI] 2.00–8.45), and practicing chemsex (OR 3.19; 95% CI 1.12–9.10). Fear of side effects and a low perceived risk of HIV infection were the two most common reasons for not using PrEP (N = 40 [33.33%] and N = 34 [28.3%], respectively). Conclusions: We found two gaps in the retrospective PrEP cascade: insufficient provision of PrEP information by healthcare providers (mainly general practitioners) and low PrEP acceptability by informed, eligible patients. More diverse healthcare providers need to be involved in PrEP prescription, and at‐risk people need to be sensitized to the risk of HIV infection. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Progressive multifocal leukoencephalopathy in patients with immunovirological control and at least 6 months of combination antiretroviral therapy

Author

Dalla-Pozza, Paul, primary, Hentzien, Maxime, additional, Allavena, Clotilde, additional, Doe de Maindreville, Anne, additional, Bouiller, Kévin, additional, Valantin, Marc-Antoine, additional, Lafont, Emmanuel, additional, Zaegel-Faucher, Olivia, additional, Cheret, Antoine, additional, Martin-Blondel, Guillaume, additional, Cotte, Laurent, additional, and Bani-Sadr, Firouzé, additional

Published
2021
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