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Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials
Authors :
Orkin, Chloe Molina, Jean-Michel Cahn, Pedro Lombaard, Johannes Supparatpinyo, Khuanchai Kumar, Sushma Campbell, Havilland Wan, Hong Teal, Valerie Jin Xu, Zhi Asante-Appiah, Ernest Sklar, Peter Teppler, Hedy Lahoulou, Rima Martins, Marcelo D Cahn, Pedro E Lopardo, Gustavo D Porteiro, Norma Bloch, Mark Theo Baker, David Alfred Roth, Norman Moore, Richard J Finlayson, Robert James McMahon, James Rieger, Armin Zoufaly, Alexander Schmied, Brigitte Hartl, Sylvia Zangerle, Robert Smaill, Fiona Walmsley, Sharon L Conway, Brian Rachlis, Anita Smith, Graham H R Perez Cortes, Carlos Afani, Alejandro Campos Barker, Maria Isabel E Chahin Anania, Carolina Eugenia Reyes, Marcelo J. Wolff Gerstoft, Jan Weis, Nina Laursen, Alex Lund Molina, Jean-Michel Yazdanpanah, Yazdan Cotte, Laurent Raffi, Francois Slama, Laurence Morlat, Philippe Girard, Pierre-Marie Katlama, Christine Rockstroh, Juergen K Arasteh, Keikawus Esser, Stefan Stoehr, Albrecht Stellbrink, Hans-Juergen Stoll, Matthias Schuermann, Dirk Faetkenheuer, Gerd Bogner, Johannes Richard Lutz, Thomas Baumgarten, Axel Jaeger, Hans Wiese, Carmen Gori, Andrea Migliorino, Guglielmo Marco Coltan, Gabriel Constandis, Felicia Erscoiu, Simona M Prisacariu, Liviu-Jany Rugina, Sorin Streinu-Cercel, Adrian Pokrovsky, Vadim V Zakharova, Natalia Shuldyakov, Andrey Anatolyevich Ryamova, Elena Pavlovna Kulagin, Valeriy Viktorovich Tsybakova, Olga Aleksandrovna Orlova-Morozova, Elena Nagimova, Firaya Voronin, Evgeniy Shimonova, Tatiana Evgenyevna Kozyrev, Oleg Anatolyevich Orrell, Catherine Lombaard, Johannes Jurgens Botes, Margaretha Elizabeth de Jager, Marleen Segorb, Joaquin Portilla Gatell Artigas, Josep Maria Mallolas Masferrer, Josep Guillen, Santiago Moreno Perez Elias, Maria Jesus Arribas Lopez, Jose R Puigmal, Eugenia Negredo Podzamczer Palter, Daniel Ortega, Frederico Pulido Garcia, Jesus Troya de los Santos Gil, Ignacio Berenguer, Juan Nelson, Mark Richard Williams, Ian G Johnson, Margaret A Khoo, Saye Schembri, Gabriel Clarke, Amanda Gompels, Mark Fox, Julie Meriel Lwanga, Julianne Taylor, Steven John Dockrell, David Harold Kegg, Stephen Hagins, Debbie P Osiyemi, Olayemi O Prelutsky, David James Ramgopal, Moti N Scarsella, Anthony J Dretler, Robin DeJesus, Edwin Bettacchi, Christopher J Sims III, James Clay, Patrick G Bellos, Nicholaos C Thompson, Melanie A Montero, Jose McDonald, Cheryl K Creticos, Catherine Shamblaw, David Terrelonge, Antonio E Valdes, Martin Tashima, Karen T Robbins, William J Elion, Richard A Goldstein, Deborah Slim, Jihad Lalezari, Jacob Paul Pushkin, Richard Lalla-Reddy, Sujata N Win, Sanda S Ruane, Peter Jerome Mills, Anthony Martin Cade, Jerry L Campo, Rafael Dietz, Craig A Hoffman-Terry, Margaret Blick, Gary Rubin, David Scott Mayer, Cynthia Rondon, Juan Carlos Cook, Paul P Daar, Eric Kumar, Princy N Swindells, Susan Castro, Jose Guillermo Morales-Ramirez, Javier O Santiago, Lizette Santana-Bagur, Jorge L Vandekerckhove, Linos Florence, Eric De Wit, Stephane Derdelinckx, Inge Vandercam, Bernard Belkhir, Leila De Wet, Joseph Lebouche, Bertrand Trottier, Benoit Longpre, Daniele Szabo, Jason LeBlanc, Roger P Jensen, Werner Gonzalez, Alvaro Rojas Beltran, Carlos Sussmann, Otto Alberto Velez, Juan Diego Onate, Jose Millan Nielsen, Henrik Degen, Olaf Stephan, Christoph Arathoon, Eduardo Lopez, Rudy Manuel Rojas Alvarado, Evelyn Michelle Gonzalez Patzan, Luis Demetrio Meija, Carlos R Pinzon, Rodolfo Parchment, Charles Sthoeger, Zev Chowers, Michal Riesenberg, Klaris Shahar, Eduardo Levy, Itzchak Quintero Perez, Nora Patricia Andrade-Villanueva, Jaime Federico Crabtree Ramirez, Brenda Eloisa Rijnders, Bart den Hollander, Jan G Handy, Rupert Morales, Nilo Bonifacio Hidalgo, Jose Alfredo Infante, Rosa Mercedes Matos Prado, Eduardo Demetrio Campos, Pablo E Ticona Chaves, Eduardo Romulo Pinedo, Yvett Pacheco, Patricia Maltez, Fernando Manuel Cunha, Jose Neves, Isabel Serrao, Rosario Melendez-Rivera, Ivan Mendoza-Rodriguez, Rafael O Maldonado-Rivera, Sandra Ortiz-Lasanta, Grisell Kizhlo, Svetlana Freud, Hernando Knobel Moreno, Jose Sanz Mendez, Francisco Vera Mohapi, Lerato Mitha, Essack Aziz Mahomed, Akbar Anvar Fouche, Leon Frederik Kaplan, Richard Siddique, Naeem Hoosen, Farzana Rassool, Mohammed Siddique Baraldi, Ezio Calmy, Alexandra Cavassini, Matthias Fehr, Jan Tsai, Hung-Chin Lin, Hsi-Hsun Huang, Chun-Kai Ko, Wen-Chien Lin, Yu-Hui Chen, Su-Jung Hung, Chien-Ching Avihingsanon, Anchalee Kiertiburanakul, Sasisopin Ratanasuwan, Winai Supparatpinyo, Khuanchai Chetchotisakd, Ploenchan Changpradub, Dhitiwat Orkin, Chloe Fox, Ashini Winston, Alan Ustianowski, Andrew Yangco, Bienvenido G Asmuth, David Michael Vigil, Karen J Berger, Daniel S Bhatti, Laveeza Campbell, Thomas Casey, Kathleen K Liu, Edward Crofoot, Gordon E Cunningham, Douglas Feinberg, Judith Fichtenbaum, Carl Balamban Felizarta, Franco Antonio Jefferson, Thomas T Johnson, Marc Alexander Lewis, Stanley T Luque, Amneris E Novak, Richard M Sloan, Louis Sweet, Donna E Towner, William J Zane, Ryan Riedel, David J Loftus, Richard Anton Shon, Alyssa So Young Mogyoros, Miguel Tebas, Pablo Scott, Mia Louise Parenti, David M Inciarte Portillo, Alexy
Source :
The Lancet HIV; February 2024, Vol. 11 Issue: 2 pe75-e85, 11p
Publication Year :
2024
Abstract
In two phase 3 trials for first-line therapy in adults with HIV-1, doravirine showed non-inferior efficacy, a favourable safety profile, and a superior lipid profile to darunavir and efavirenz through to 48 and 96 weeks. Here we report 192-week results from both studies.
Details
Language :
English
ISSN :
24054704 and 23523018
Volume :
11
Issue :
2
Database :
Supplemental Index
Journal :
The Lancet HIV
Publication Type :
Periodical
Accession number :
ejs64990082
Full Text :
https://doi.org/10.1016/S2352-3018(23)00258-8